Eva Maria del Amo Páez
Senior Researcher
My main interest is in intravitreal pharmacokinetics and pharmacodynamics of biologicals for the ...
School of Pharmacy, Faculty of Health Sciences
[email protected] | +358 40 355 3883
Eva Maria del Amo, received her Ph.D. from the University of Helsinki with her dissertation “Ocular and Systemic Pharmacokinetic Models for Drug Discovery and Development” in 2015, and continued her research at the University of Eastern Finland, Kuopio in the ocular drug delivery research group under prof. Arto Urtti’s supervision. In 2018, she moved to Manchester where she started a Marie-Curie fellowship (Horizon 2020, https://cordis.europa.eu/project/id/799880) at the Centre for Applied Pharmacokinetic Research, at the University of Manchester. Her research focused on Pharmacokinetic-Pharmacodynamic models for patients with neovascular age-macular degeneration with anti-VEGF treatment, under the mentorship of prof. Leon Aarons and in collaboration with prof. Paul Bishop. In 2020, she returned to the University of Eastern Finland with the Orion Research Foundation grant to pursue her research interests on: the application of modeling and simulation techniques to characterize the pharmacokinetics and pharmacodynamics of ocular drugs, guide dosing prtocols, and improve drug treatment in patients with retinal diseases. Moreover, she is interested in drug binding to ocular melanin pigment to sustain therapy action. Apart from pharmacometrics, she is trained in Quantitative Structure Property Relationship (QSPR) and chemoinformatics.Her computational models to describe and predict intravitreal pharmacokinetic in rabbits and humans have been followed and utilized by several small and big pharmaceutical companies as well as in Academia.
Currently, Eva Maria del Amo is a docent in the field of pharmacokinetic modeling and simulations, and research Fellow in the research community Drug Discovery and Delivery Technologies at the University of Eastern Finland. She has published more than 40 publications including peer reviewed scientific articles and book chapters that have received >3300 citations (h-index 24). She has supervised 9 PhD students from Finland, UK, and USA (4 graduated), and 6 MSc and Bachelor students. She is a reviewer for journals such as Int J Pharm, Mol Pharm, Expert Opin Drug Deliv, Eur J Pharm Biopharm, Commun BioL and Drug Deliv Transl Res. She has acted as examiner for 7 evaluations on associate professorship, international PhD thesis and MSc thesis examinations.
Research groups
Publications
50/50 items-
Comprehensive Pharmacokinetic Evaluation of High Melanin Binder Levofloxacin in Rabbits Shows Potential of Topical Eye Drops for Posterior Segment Treatment
Bahrpeyma, Sina; Jakubiak, Paulina; Alvarez-Sánchez, Rubén; Caruso, Antonello; Leuthardt, Monika; Senn, Claudia; del Amo, Eva M.; Urtti, Arto. 2024. Investigative ophthalmology and visual science. 65: A1 Journal article (refereed), original research -
Comprehensive ocular and systemic pharmacokinetics of dexamethasone after subconjunctival and intravenous injections in rabbits
Valtari, Annika; Posio, Susanna; Toropainen, Elisa; Balla, Anusha; Puranen, Jooseppi; Sadeghi, Amir; Ruponen, Marika; Ranta, Veli-Pekka; Vellonen, Kati-Sisko; Urtti, Arto; del Amo, Eva M. 2024. European journal of pharmaceutics and biopharmaceutics. 198: A1 Journal article (refereed), original research -
Mathematical Models of Ocular Drug Delivery
Sadeghi, Amir; Subrizi, Astrid; del Amo, Eva M; Urtti, Arto. 2024. Investigative ophthalmology and visual science. 65: A2 Review article, Literature review, Systematic review -
Mass spectrometry in ocular drug research
del Amo, Eva M.; Vellonen, Kati‐Sisko; Urtti, Arto; Terasaki, Tetsuya; Hammid, Anam; Honkakoski, Paavo; Auriola, Seppo. 2023. Mass spectrometry reviews. [First published: 02 August 2023]: 1-32 A2 Review article, Literature review, Systematic review -
Topical pharmacokinetics of brinzolamide suspensions in rabbits and variability analysis for sample size and design considerations
Naageshwaran, Vatsala; Bigonne, Hélène; Gum, Glenwood; Malla, Spundana; del Sol, Charity; Bon, Charles; Xu, Xiaoming; Vo, Anh; Smith, William; O'Reilly Beringhs, Andre; Kozak, Darby; Tan, Ming Liang; Babiskin, Andrew; Urtti, Arto; del Amo, Eva M.; Ranta, Veli Pekka. 2023. International journal of pharmaceutics. 642: . 123183 A1 Journal article (refereed), original research -
Towards a population pharmacokinetic/pharmacodynamic model of anti-VEGF therapy in patients with age-related macular degeneration
del Amo, Eva M; Bishop, Paul N; Godia, Pere; Aarons, Leon. 2023. European journal of pharmaceutics and biopharmaceutics. 188: 78-88 A1 Journal article (refereed), original research -
Comments on “Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials”
del Amo, Eva M; Urtti, Arto; Ranta, Veli-Pekka. 2022. Journal of pharmacology and experimental therapeutics. 383: 246-247 B1 Non-refereed journal articles -
Liposomal sunitinib for ocular drug delivery: A potential treatment for choroidal neovascularization
Tavakoli, Shirin; Puranen, Jooseppi; Bahrpeyma, Sina; Lautala, Veera E.; Karumo, Suvi; Lajunen, Tatu; del Amo, Eva M.; Ruponen, Marika; Urtti, Arto. 2022. International journal of pharmaceutics. 620: A1 Journal article (refereed), original research -
Mechanisms of cellular retention of melanin bound drugs: Experiments and computational modeling
Bahrpeyma, Sina; Reinisalo, Mika; Hellinen, Laura; Auriola, Seppo; del Amo, Eva M; Urtti, Arto. 2022. Journal of controlled release. 348: 760-770 A1 Journal article (refereed), original research -
Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations
del Amo, Eva M.; Hammid, Anam; Tausch, Melanie; Toropainen, Elisa; Sadeghi, Amir; Valtari, Annika; Puranen, Jooseppi; Reinisalo, Mika; Ruponen, Marika; Urtti, Arto; Sauer, Achim; Honkakoski, Paavo. 2022. International journal of pharmaceutics. 613: A1 Journal article (refereed), original research