Tarja Malm
Professor
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
[email protected] | +358 40 355 2209
I lead the Neuroinflammation research group. We aim to find regulators of microglial dysfunctions in neurodegenerative diseases.
To find out more of our research, please visit:
https://sites.uef.fi/tarja-malm-group/research-details/
Research groups
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Biomedical MRI 01.01.1995 - -
In vitro and ex vivo electrophysiology core facility 01.01.2020 - -
Neuroinflammation research group 01.01.2017 - -
NPH and Early AD 01.01.2010 -
Projects
Publications
174/174 items-
Non-neuronal mechanisms in autism spectrum disorder (ASD): Microglia and astrocytes at the crossroads with neurons
Jäntti, Henna; Michels, Susanne; Cherubini, Enrico; Giniatullin, Rashid; Malm, Tarja, 2026, Brain behavior and immunity, 133, 106275. A1 Journal article (refereed), original research -
Overproduction of 42 Amino Acids Long Amyloid Beta Leads to Activation of Secretory Autophagy and Development of Drusen‐Like Structures Originating From Retinal Pigment Epithelium
Ruuth, Johanna; Tamminen, Toni; Toropainen, Elisa; Tanila, Heikki; Hyttinen, Juha MT; Malm, Tarja; Kaarniranta, Kai; Koskela, Ali, 2026, Faseb journal, 40, 5, e71608. A1 Journal article (refereed), original research -
Polystyrene nanoplastics modulate neurite length in a size-specific manner
Górová, Veronika; Lai, Thuy Thi; Afonin, Alexey M; Nemeth, Kore; Pelkonen, Anssi; Malm, Tarja; Jalava, Pasi; Lampinen, Riikka; Kanninnen, Katja M, 2026, NanoImpact, 41, 100614. A1 Journal article (refereed), original research -
Biopsies from Idiopathic Normal Pressure Hydrocephalus Patients as a Window to the Events of Early Alzheimer's disease: Beta‐amyloid and Tau Pathologies Alter Synaptic Transmission in Human Brain
Dougalis, Antonios; Abushik, Polina; Pelkonen, Anssi; Giudice, Luca; Gomez‐Budia, Mireia; Novosolova, Nataliia; Välimäki, Nelli‐Noora; Rezaie, Mohammad; Nurkhametova, Dilyara; Giniatullina, Raisa; Shakirzyanova, Anastasia; Mali, Akash; de Kock, Christiaan PJ; Mertens, Eline J; Mansvelder, Huibert D; Stevens, Beth; Macosko, Evan; Hiltunen, Mikko; Rauramaa, Tuomas; Leinonen, Ville; Malm, Tarja, 2025, Alzheimer's & dementia. Abstract -
Brain-targeted Jedi1 and Jedi2 derivatives as potent enhancers of Piezo1 ion channel activity
Anamea, Landry; Králová, Adéla; Tampio, Janne; Shakirzyanova, Anastasia; Hänninen, Milka; Giniatullin, Rashid; Jalkanen, Aaro J; Malm, Tarja; Huttunen, Kristiina M, 2025, European journal of medicinal chemistry, 302, Part 2, 118359. A1 Journal article (refereed), original research -
Discovery of Novel CSF Clearance Mechanism of Idiopathic Normal Pressure Hydrocephalus and Alzheimer's Disease
Lipponen, Anssi; Heikkinen, Sami; Räsänen, Joel; Macosko, Evan; Malm, Tarja; Hiltunen, Mikko; Leinonen, Ville, 2025, Alzheimer's & dementia. Poster -
Frequency‐Dependent Diffusion–Relaxation Distribution MRI: Scan–Rescan Reproducibility Ex Vivo and Caveats
Or, Pak Shing Kenneth; Yon, Maxime; Narvaez, Omar; Manninen, Eppu; Malm, Tarja; Sierra, Alejandra; Topgaard, Daniel; Benjamini, Dan, 2025, Nmr in biomedicine, 39, 2, 1-16. A1 Journal article (refereed), original research -
Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage
Huber, Nadine; Hietanen, Tomi; Heikkinen, Sami; Shakirzyanova, Anastasia; Hoffmann, Dorit; Rostalski, Hannah; Dhingra, Ashutosh; Rodriguez-Nieto, Salvador; Kärkkäinen, Sari; Koskuvi, Marja; Korhonen, Eila; Hartikainen, Päivi; Pylkäs, Katri; Krüger, Johanna; Malm, Tarja; Takalo, Mari; Hiltunen, Mikko; Koistinaho, Jari; Portaankorva, Anne M; Solje, Eino; Haapasalo, Annakaisa, 2025, Molecular psychiatry, 31, 3, 1500-1516. A1 Journal article (refereed), original research -
Germinal center trajectories and transcriptional signatures define CLL subtypes and their pathway regulators
Mohamed, Ahmed; Giudice, Luca; Basílio, José; Barresi, Sabina; Kopparapu, Pradeep Kumar; Friman, Vanda; Tartaglia, Marco; Malm, Tarja; Tilevik, Andreas; Grimsholm, Ola, 2025, PLoS ONE, 20, 10, e0335069. A1 Journal article (refereed), original research -
Increased activity of Piezo1 channel in red blood cells is associated with Alzheimer's disease-related dementia
Sitnikova, Valeriia; Nurkhametova, Dilyara; Braidotti, Nicoletta; Ciubotaru, Catalin, D; Giudice, Luca; Impola, Ulla; Kärkkäinen, Sari;Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Fagerlund, Ilkka; Kanninen, Katja, M; Zetterberg, Henrik; Kokkola, Tarja; Laitinen Saara; Koivisto, Anne; Cojoc, Dan; Giniatullin, Rashid; Malm, Tarja, M, 2025, Alzheimer's & dementia, 21, 6, e70368. A1 Journal article (refereed), original research