Tarja Malm

Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage

Huber, Nadine; Hietanen, Tomi; Heikkinen, Sami; Shakirzyanova, Anastasia; Hoffmann, Dorit; Rostalski, Hannah; Dhingra, Ashutosh; Rodriguez-Nieto, Salvador; Kärkkäinen, Sari; Koskuvi, Marja; Korhonen, Eila; Hartikainen, Päivi; Pylkäs, Katri; Krüger, Johanna; Malm, Tarja; Takalo, Mari; Hiltunen, Mikko; Koistinaho, Jari; Portaankorva, Anne M; Solje, Eino; Haapasalo, Annakaisa, 2025, Molecular psychiatry, [Published: 26 September 2025], 1-17. A1 Journal article (refereed), original research

Germinal center trajectories and transcriptional signatures define CLL subtypes and their pathway regulators

Mohamed, Ahmed; Giudice, Luca; Basílio, José; Barresi, Sabina; Kopparapu, Pradeep Kumar; Friman, Vanda; Tartaglia, Marco; Malm, Tarja; Tilevik, Andreas; Grimsholm, Ola, 2025, PLoS ONE, 20, 10, e0335069. A1 Journal article (refereed), original research

Increased activity of Piezo1 channel in red blood cells is associated with Alzheimer's disease-related dementia

Sitnikova, Valeriia; Nurkhametova, Dilyara; Braidotti, Nicoletta; Ciubotaru, Catalin, D; Giudice, Luca; Impola, Ulla; Kärkkäinen, Sari;Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Fagerlund, Ilkka; Kanninen, Katja, M; Zetterberg, Henrik; Kokkola, Tarja; Laitinen Saara; Koivisto, Anne; Cojoc, Dan; Giniatullin, Rashid; Malm, Tarja, M, 2025, Alzheimer's & dementia, 21, 6, e70368. A1 Journal article (refereed), original research

Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU-005 reduces ex vivo cortical spreading depression

Brugia, Flavia; Ivanov, Konstantin; Aroviita, Auni; Giniatullina, Raisa; Lehtonen, Marko; Malm, Tarja; Savinainen, Juha; Giniatullin, Rashid; Della Pietra, Adriana, 2025, Journal of headache and pain, 26, 1, 85. A1 Journal article (refereed), original research

Microglial involvement in autism spectrum disorder: insights from human data and iPSC models

Michels, Susanne; Mali, Akash; Jäntti, Henna; Rezaie, Mohammad; Malm, Tarja, 2025, Brain behavior and immunity, 130, 106071. A1 Journal article (refereed), original research

Mitochondrial and energy metabolism dysfunctions are hallmarks of TDP-43G376D fibroblasts from members of an Amyotrophic Lateral Sclerosis family

Perciballi, Elisa; Bovio, Federica; Ferro, Sara; Forcella, Matilde; Rosati, Jessica; Carletti, Rose Mary; D’Anzi, Angela; Gelati, Maurizio; La Bella, Vincenzo; Innocenti, Metello; Spataro, Rossella; Pecoraro, Martina; Lombardi, Ivan; Vulcano, Edvige; Ruotolo, Giorgia; Mercurio, Sara; Sabatelli, Mario; Lattante, Serena; Malm, Tarja; Ohtonen, Sohvi; Vescovi, Angelo Luigi; Fusi, Paola; Ferrari, Daniela, 2025, Cell death and disease, 16, 1, 1-10. A1 Journal article (refereed), original research

Modeling neuroinflammatory interactions between microglia and astrocytes in a human iPSC-based coculture platform

Tujula, Iisa; Hyvärinen, Tanja; Lotila, Johanna; Rogal, Julia; Voulgaris, Dimitrios; Sukki, Lassi; Tornberg, Kaisa; Korpela, Katri; Jäntti, Henna; Malm, Tarja; Herland, Anna; Kallio, Pasi; Narkilahti, Susanna; Hagman, Sanna, 2025, Cell communication and signaling, 23, 1, 298. A1 Journal article (refereed), original research

Molecular Determinants of Protein Pathogenicity at the Single‐Aggregate Level

Urbanek, Agnieszka; Garland, Emma F; Prescott, Emily E; King, Marianne C; Olerinyova, Anna; Wareing, Hollie E; Georgieva, Nia; Bradshaw, Ellie L; Tzokov, Svetomir B; Knight, Alexander; Tartakovskii, Alexander I; Malm, Tarja; Highley, J Robin; De, Suman, 2025, Advanced science, 12, 9, 2410229. A1 Journal article (refereed), original research

Obesity is associated with increased brain glucose uptake and activity but not neuroinflammation (TSPO availability) in monozygotic twin pairs discordant for BMI—Exercise training reverses increased brain activity

Hentilä, Jaakko; Tuisku, Jouni; Ojala, Ronja; Sun, Lihua; Lietzén, Martin S.; Virtanen, Heidi; Lautamäki, Riikka; Koskensalo, Kalle; Nummenmaa, Lauri; Löyttyniemi, Eliisa; Helin, Semi; Pietiläinen, Kirsi H.; Kaprio, Jaakko; Lahti, Leo; Malm, Tarja; Rinne, Juha O.; Hannukainen, Jarna C., 2025, Diabetes obesity and metabolism, [Epub ahead of print 10 September 2025], 1-13. A1 Journal article (refereed), original research

Oxidative modulation of Piezo1 channels

Novosolova, N; Braidotti, N; Patinen, T; Laitinen, T; Ciubotaru, C; Huttunen, KM; Levonen, AL; Cojoc, D; Giniatullin, R; Malm, T, 2025, Redox biology, 86, 103797. A1 Journal article (refereed), original research

Segment Anything for Dendrites from Electron Microscopy

Zhuo, Zewen; Belevich, Ilya; Leinonen, Ville; Jokitalo, Eija; Malm, Tarja; Sierra, Alejandra; Tohka, Jussi, 2025, The Sixth IEEE International Image Processing, Applications and Systems Conference (IPAS'6) - Conference Proceedings, 1-6. A4 Conference proceedings

The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions

Takalo, Mari; Jeskanen, Heli; Rolova, Taisia; Kervinen, Inka; Hellén, Marianna; Heikkinen, Sami; Koivisto, Hennariikka; Jokivarsi, Kimmo; Müller, Stephan A.; Koivumäki, Esa-Mikko; Mäkinen, Petra; Juopperi, Sini-Pauliina; Willman, Roosa-Maria; Sinisalo, Rosa; Hoffmann, Dorit; Jäntti, Henna; Peitz, Michael; Fließbach, Klaus; Kuulasmaa, Teemu; Natunen, Teemu; Kemppainen, Susanna; Poutiainen, Pekka; Leinonen, Ville; Malm, Tarja; Martiskainen, Henna; Ramirez, Alfredo; Haapasalo, Annakaisa; Lichtentha, 2025, Journal of neuroinflammation, 22, 1, 64. A1 Journal article (refereed), original research

Traffic-related diesel pollution particles impair the lysosomal functions of human iPSC-derived microglia

Ohtonen, Sohvi; Jäntti, Henna; Giudice, Luca; Mohamed, Ahmed; Shakirzyanova, Anastasia; Závodná, Táňa; Belevich, Ilya; Yan, Hong; Sabogal-Guáqueta, Angélica María; Saveleva, Liudmila; Väänänen, Mari-Anna; Rillo-Albert, Ashley; Perciballi, Elisa; Ferrari, Daniela; Tervo, Minna-Mari; Gómez-Budia, Mireia; Krejčík, Zdeněk; Aakko-Saksa, Päivi; Koistinaho, Jari; Lehtonen, Šárka; Kanninen, Katja M.; Topinka, Jan; Jokitalo, Eija; Sierra, Alejandra; Schmidt, Martina; Dolga, Amalia M.; Jalava, Pasi I.; Ko, 2025, Environment international, 199, 109467. A1 Journal article (refereed), original research

Traffic-related ultrafine particles influence gene regulation in olfactory mucosa cells altering PI3K/AKT signaling

Mussalo, Laura; Afonin, Alexey M.; Zavodna, Tana; Krejcik, Zdenek; Honkova, Katerina; Fayad, Claire; Shahbaz, Muhammad Ali; Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Malm, Tarja; Topinka, Jan; Jalava, Pasi; Lampinen, Riikka; Kanninen, Katja M, 2025, Environment international, 199, 109484. A1 Journal article (refereed), original research

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease

Xia, Zengjie; Prescott, Emily E; Urbanek, Agnieszka; Wareing, Hollie E; King, Marianne C; Olerinyova, Anna; Dakin, Helen; Leah, Tom; Barnes, Katy A; Matuszyk, Martyna M; Dimou, Eleni; Hidari, Eric; Zhang, Yu P; Lam, Jeff Y. L; Danial, John SH; Strickland, Michael R; Jiang, Hong; Thornton, Peter; Crowther, Damian C. Ohtonen, Sohvi; Gómez-Budia, Mireia; Bell, Simon M; Ferraiuolo, Laura; Mortiboys, Heather; Higginbottom, Adrian; Wharton, Stephen B; Holtzman, David M; Malm, Tarja; Ranasinghe, Rohan, 2024, Nature communications, 15, 1, 4695. A1 Journal article (refereed), original research

Effects of Obesity and Exercise on Hepatic and Pancreatic Lipid Content and Glucose Metabolism: PET Studies in Twins Discordant for BMI

Lietzén, Martin S.; Mari, Andrea; Ojala, Ronja; Hentilä, Jaakko; Koskensalo, Kalle; Lautamäki, Riikka; Löyttyniemi, Eliisa; Parkkola, Riitta; Saunavaara, Virva; Kirjavainen, Anna K.; Rajander, Johan; Malm, Tarja; Lahti, Leo; Rinne, Juha O.; Pietiläinen, Kirsi H.; Iozzo, Patricia; Hannukainen, Jarna C., 2024, Biomolecules, 14, 9, 1070. A1 Journal article (refereed), original research

Emerging Models to Study Human Microglia In vitro

Jäntti, Henna; Kistemaker, Lois; Buonfiglioli, Alice; De Witte, Lot D.; Malm, Tarja; Hol, Elly M., 2024, Tremblay, Marie-Ève; Verkhratsky, Alexei, Microglia: Physiology, Pathophysiology and Therapeutic Potential, 545-568. A3 Book section, Chapters in research books

Mechanisms Leading to Increased Insulin-Stimulated Cerebral Glucose Uptake in Obesity and Insulin Resistance: A High-Fat Diet and Exercise Training Intervention PET Study with Rats (CROSRAT)

Jalo, Anna; Helin, Jatta S; Hentilä, Jaakko; Nissinen, Tuuli A; Honkala, Sanna M; Heiskanen, Marja A; Löyttyniemi, Eliisa; Malm, Tarja; Hannukainen, Jarna C, 2024, Journal of functional morphology and kinesiology, 9, 2, 58. A1 Journal article (refereed), original research

Particulate matter from car exhaust alters function of human iPSC-derived microglia

Jäntti, Henna; Jonk, Steffi; Gómez Budia, Mireia; Ohtonen, Sohvi; Fagerlund, Ilkka; Fazaludeen, Mohammad Feroze; Aakko-Saksa, Päivi; Pebay, Alice; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Jalava, Pasi I; Malm, Tarja; Korhonen, Paula, 2024, Particle and fibre toxicology, 21, 1, 6. A1 Journal article (refereed), original research

Regular Exercise Training Induces More Changes on Intestinal Glucose Uptake from Blood and Microbiota Composition in Leaner Compared to Heavier Individuals in Monozygotic Twins Discordant for BMI

Lietzén, Martin S.; Guzzardi, Maria Angela; Ojala, Ronja; Hentilä, Jaakko; Heiskanen, Marja A.; Honkala, Sanna M.; Lautamäki, Riikka; Löyttyniemi, Eliisa; Kirjavainen, Anna K.; Rajander, Johan; Malm, Tarja; Lahti, Leo; Rinne, Juha O.; Pietiläinen, Kirsi H.; Iozzo, Patricia; Hannukainen, Jarna C., 2024, Nutrients, 16, 20, 3554. A1 Journal article (refereed), original research

SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion

Christ, Wanda; Kapell, Sebastian; Sobkowiak, Michal J; Mermelekas, Georgios; Evertsson, Björn; Sork, Helena; Saher, Osama; Bazaz, Safa; Gustafsson, Oskar; Cardenas, Eduardo I; Villa, Viviana; Ricciarelli, Roberta; Sandberg, Johan K; Bergquist, Jonas; Sturchio, Andrea; Svenningsson, Per; Malm, Tarja; Espay, Alberto J; Pernemalm, Maria; Lindén, Anders; Klingström, Jonas; El Andaloussi, Samir; Ezzat, Kariem, 2024, Acs chemical neuroscience, 15, 2, 4095-4104. A1 Journal article (refereed), original research

StellarPath: Hierarchical-vertical multi-omics classifier synergizes stable markers and interpretable similarity networks for patient profiling

Giudice, Luca; Mohamed, Ahmed; Malm, Tarja, 2024, PLoS computational biology, 20, 4, e1012022. A1 Journal article (refereed), original research

Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology

Antila, Salli; Chilov, Dmitri; Nurmi, Harri; Li, Zhilin; Näsi, Anni; Gotkiewicz, Maria; Sitnikova, Valeriia; Jäntti, Henna; Acosta, Natalia; Koivisto, Hennariikka; Ray, Jonathan; Keuters, Meike Hedwig; Sultan, Ibrahim; Scoyni, Flavia; Trevisan, Davide; Wojciechowski, Sara; Kaakinen, Mika; Dvořáková, Lenka; Singh, Abhishek; Jukkola, Jari; Korvenlaita, Nea; Eklund, Lauri; Koistinaho, Jari; Karaman, Sinem; Malm, Tarja; Tanila, Heikki; Alitalo, Kari, 2024, Nature cardiovascular research, 3, 4, 474-491. A1 Journal article (refereed), original research

Traffic-related ultrafine particles impair mitochondrial functions in human olfactory mucosa cells – Implications for Alzheimer's disease

Mussalo, Laura; Lampinen, Riikka; Avesani, Simone; Závodná, Táňa; Krejčík, Zdeněk; Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Malm, Tarja; Topinka, Jan; Giugno, Rosalba; Jalava, Pasi; Kanninen, Katja M, 2024, Redox biology, 75, 103272. A1 Journal article (refereed), original research

Transcriptomic and epigenomic profiling reveals altered responses to diesel emissions in Alzheimer's disease both in vitro and in population-based data

Saveleva, Liudmila; Cervena, Tereza; Mengoni, Claudia; Sima, Michal; Krejcik, Zdenek; Vrbova, Kristyna; Sikorova, Jitka; Mussalo, Laura; de Crom, Tosca O E; Šímová, Zuzana; Ivanova, Mariia; Shahbaz, Muhammad Ali; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Ikram, M Arfan; Jalava, Pasi I; Malm, Tarja; Chew, Sweelin; Vojtisek‐Lom, Michal; Topinka, Jan; Giugno, Rosalba; Rössner, Pavel; Kanninen, Katja M, 2024, Alzheimer's & dementia, 20, 12, 8825-8843. A1 Journal article (refereed), original research

Uptake of alpha‐synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia

Niskanen, Jonna; Peltonen, Sanni; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Luk, Kelvin C; Giudice, Luca; Koistinaho, Jari; Malm, Tarja; Goldsteins, Gundars; Albert, Katrina; Lehtonen, Šárka, 2024, Glia, 2025; 73, 1, 159-174. A1 Journal article (refereed), original research

ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling

Scoyni, Flavia; Sitnikova, Valeriia; Giudice, Luca; Korhonen, Paula; Trevisan, Davide M; Hernandez de Sande, Ana; Gomez-Budia, Mireia; Giniatullina, Raisa; Ugidos, Irene F; Dhungana, Hiramani; Pistono, Cristiana; Korvenlaita, Nea; Välimäki, Nelli-Noora; Kangas, Salla M; Hiltunen, Anniina E; Gribchenko, Emma; Kaikkonen-Määttä, Minna U; Koistinaho, Jari; Ylä-Herttuala, Seppo; Hinttala, Reetta; Venø, Morten T; Su, Junyi; Stoffel, Markus; Schaefer, Anne; Rajewsky, Nikolaus; Kjems, Jørgen; LaPierre,, 2024, Cell reports, 43, 3, 113862. A1 Journal article (refereed), original research

Alzheimer's disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs

Scoyni, Flavia; Giudice, Luca; Väänänen, Mari Anna; Downes, Nicholas; Korhonen, Paula; Choo, Xin Yi; Välimäki, Nelli Noora; Mäkinen, Petri; Korvenlaita, Nea; Rozemuller, Annemieke J; de Vries, Helga E; Polo, Jose; Turunen, Tiia A; Ylä-Herttuala, Seppo; Hansen, Thomas B; Grubman, Alexandra; Kaikkonen, Minna U; Malm, Tarja, 2023, Alzheimer's & dementia, 2024; 20, 2, 954-974. A1 Journal article (refereed), original research

Bone marrow metabolism is affected by body weight and response to exercise training varies according to anatomical location

Ojala, Ronja; Hentilä, Jaakko; Lietzén, Martin S; Arponen, Milja; Heiskanen, Marja A; Honkala, Sanna M; Virtanen, Heidi; Koskensalo, Kalle; Lautamäki, Riikka; Löyttyniemi, Eliisa; Parkkola, Riitta; Heinonen, Olli J; Malm, Tarja; Lahti, Leo; Rinne, Juha; Eskola, Olli; Rajander, Johan; Pietiläinen, Kirsi H; Kaprio, Jaakko; Ivaska, Kaisa K.; Hannukainen, Jarna C, 2023, Diabetes obesity and metabolism, 2024; 26, 1, 251-261. A1 Journal article (refereed), original research

Construction of Fusion Protein for Enhanced Small RNA Loading to Extracellular Vesicles

Es-Haghi, Masoumeh; Neustroeva, Olga; Chowdhury, Iftekhar; Laitinen, Pia; Väänänen, Mari-Anna; Korvenlaita, Nea; Malm, Tarja; Turunen, Mikko P; Turunen, Tiia A, 2023, Genes, 14, 2, 261. A1 Journal article (refereed), original research

Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia

Korvenlaita, Nea; Gómez‐Budia, Mireia; Scoyni, Flavia; Pistono, Cristiana; Giudice, Luca; Eamen, Shaila; Loppi, Sanna; de Sande, Ana Hernández; Huremagic, Benjamin; Bouvy‐Liivrand, Maria; Heinäniemi, Merja; Kaikkonen, Minna U.; Cheng, Lesley; Hill, Andrew F.; Kanninen, Katja M.; Jenster, Guido W.; van Royen, Martin E.; Ramiro, Laura; Montaner, Joan; Batkova, Tereza; Mikulik, Robert; Giugno, Rosalba; Jolkkonen, Jukka; Korhonen, Paula; Malm, Tarja, 2023, Journal of extracellular vesicles, 12, 1, 12297. A1 Journal article (refereed), original research

Early Alzheimer's disease pathology in human cortex involves transient cell states

Gazestani, Vahid; Kamath, Tushar; Nadaf, Naeem M; Dougalis, Antonios; Burris, SJ; Rooney, Brendan; Junkkari, Antti; Vanderburg, Charles; Pelkonen, Anssi; Gomez-Budia, Mireia; Välimäki, Nelli Noora; Rauramaa, Tuomas; Therrien, Martine; Koivisto, Anne M; Tegtmeyer, Matthew; Herukka, Sanna Kaisa; Abdulraouf, Abdulraouf; Marsh, Samuel E; Hiltunen, Mikko; Nehme, Ralda; Malm, Tarja; Stevens, Beth; Leinonen, Ville; Macosko, Evan Z, 2023, Cell, 186, 20, 4438-4453.e23. A1 Journal article (refereed), original research

Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment

Mussalo, Laura; Avesani, Simone; Shahbaz, Muhammad Ali; Zavodna, Tana; Saveleva, Liudmila; Järvinen, Anssi; Lampinen, Riikka; Belaya, Irina; Krejcik, Zdenek; Ivanova, Mariia; Hakkarainen, Henri; Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Malm, Tarja; Topinka, Jan; Giugno, Rosalba; Aakko-Saksa, Päivi; Chew, Sweelin; Rönkkö, Topi; Jalava, Pasi; Kanninen, Katja M, 2023, Science of the total environment, 905, 167038. A1 Journal article (refereed), original research

Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function

Ohtonen, Sohvi; Giudice, Luca; Jäntti, Henna; Fazaludeen, Mohammad Feroze; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Välimäki, Nelli-Noora; Niskanen, Jonna; Korvenlaita, Nea; Fagerlund, Ilkka; Koistinaho, Jari; Amiry-Moghaddam, Mahmood; Savchenko, Ekaterina; Roybon, Laurent; Lehtonen, Šárka; Korhonen, Paula; Malm, Tarja, 2023, Scientific reports, 13, 1, 22118. A1 Journal article (refereed), original research

Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI)

Liu, Jie; van Beusekom, Heleen; Bu, Xian‐Le; Chen, Gong; Henrique Rosado de Castro, Paulo; Chen, Xiaochun; Chen, Xiaowei; Clarkson, Andrew N.; Farr, Tracy D.; Fu, Yuhong; Jia, Jianping; Jolkkonen, Jukka; Kim, Woojin Scott; Korhonen, Paula; Li, Shen; Liang, Yajie; Liu, Guang‐Hui; Liu, Guiyou; Liu, Yu‐Hui; Malm, Tarja; Mao, Xiaobo; Oliveira, Joaquim Miguel; Modo, Mike M.; Ramos‐Cabrer, Pedro; Ruscher, Karsten; Song, Weihong; Wang, Jun; Wang, Xuanyue; Wang, Yun; Wu, Haitao; Xiong, Lize; Yang, Yi; Y, 2023, Neuroprotection, 1, 2, 84-98. B1 Non-refereed journal articles

Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation

Chernyaeva, Larisa; Ratti, Giorgio; Teirilä, Laura; Fudo, Satoshi; Rankka, Uni; Pelkonen, Anssi; Korhonen, Paula; Leskinen, Katarzyna; Keskitalo, Salla; Salokas, Kari; Gkolfinopoulou, Christina; Crompton, Katrina E; Javanainen, Matti; Happonen, Lotta; Varjosalo, Markku; Malm, Tarja; Leinonen, Ville; Chroni, Angeliki; Saavalainen, Päivi; Meri, Seppo; Kajander, Tommi; Wollman, Adam JM; Nissilä, Eija; Haapasalo, Karita, 2023, Embo reports, 24, 7, e56467. A1 Journal article (refereed), original research

Transcriptomic Alterations in the Olfactory Bulb Induced by Exposure to Air Pollution: Identification of Potential Biomarkers and Insights into Olfactory System Function

Saveleva, Liudmila; Sima, Michal; Klema, Jiri; Krejčík, Zdeněk; Vartiainen, Petra; Sitnikova, Valeriia; Belaya, Irina; Malm, Tarja; Jalava, Pasi I; Rössner, Pavel; Kanninen, Katja M, 2023, Environmental toxicology and pharmacology, 104, 104316. A1 Journal article (refereed), original research

Activation of Meningeal Afferents Relevant to Trigeminal Headache Pain after Photothrombotic Stroke Lesion: A Pilot Study in Mice

Krivoshein, Georgii; Bakreen, Abdulhameed; van den Maagdenberg, Arn MJM; Malm, Tarja; Giniatullin, Rashid; Jolkkonen, Jukka, 2022, International journal of molecular sciences, 23, 20, 12590. A1 Journal article (refereed), original research

Air Pollution Exposure Increases ABCB1 and ASCT1 Transporter Levels in Mouse Cortex

Puris, Elena; Saveleva, Liudmila; Górová, Veronika; Vartiainen, Petra; Kortelainen, Miika; Lamberg, Heikki; Sippula, Olli; Malm, Tarja; Jalava, Pasi I; Auriola, Seppo; Fricker, Gert; Kanninen, Katja M, 2022, Environmental toxicology and pharmacology, 96, 104003. A1 Journal article (refereed), original research

Astrocyte Progenitors Derived From Patients With Alzheimer Disease Do Not Impair Stroke Recovery in Mice

Välimäki, Nelli-Noora; Bakreen, Abdulhameed; Häkli, Sara; Dhungana, Hiramani; Keuters, Meike H; Dunlop, Yannick; Koskuvi, Marja; Keksa-Goldsteine, Velta; Oksanen, Minna; Jäntti, Henna; Lehtonen, Šárka; Malm, Tarja; Koistinaho, Jari; Jolkkonen, Jukka, 2022, Stroke, 53, 10, 3192-3201. A1 Journal article (refereed), original research

Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease

Garcia, Gonçalo; Pinto, Sara; Ferreira, Sofia; Lopes, Daniela; Serrador, Maria João; Fernandes, Adelaide; Vaz, Ana Rita; Mendonça, Alexandre de; Edenhofer, Frank; Malm, Tarja; Koistinaho, Jari; Brites, Dora, 2022, Cells, 11, 21, 3377. A1 Journal article (refereed), original research

High Soluble Amyloid-β42 Predicts Normal Cognition in Amyloid-Positive Individuals with Alzheimer’s Disease-Causing Mutations

Sturchio, Andrea; Dwivedi, Alok K; Malm, Tarja; Wood, Matthew JA; Cilia, Roberto; Sharma, Jennifer S; Hill, Emily J; Schneider, Lon S; Graff-Radford, Neill R; Mori, Hiroshi; Nübling, Georg; El Andaloussi, Samir; Svenningsson, Per; Ezzat, Kariem; Espay, Alberto J; the Dominantly Inherited Alzheimer Consortia (DIAN), 2022, Journal of Alzheimer's disease, 90, 1, 333-348. A1 Journal article (refereed), original research

Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

Jäntti, Henna; Oksanen, Minna; Kettunen, Pinja; Manta, Stella; Mouledous, Lionel; Koivisto, Hennariikka; Ruuth, Johanna; Trontti, Kalevi; Dhungana, Hiramani; Keuters, Meike; Weert, Isabelle; Koskuvi, Marja; Hovatta, Iiris; Linden, Anni-Maija; Rampon, Claire; Malm, Tarja; Tanila, Heikki; Koistinaho, Jari; Rolova, Taisia, 2022, Cells, 11, 24, 4116. A1 Journal article (refereed), original research

Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation

Byts, Nadiya; Sharma, Subodh; Malm, Tarja; Kaakinen, Mika; Korhonen, Paula; Jaakkonen, Laura; Keuters, Meike; Huuskonen, Mikko; Pietilä, Ilkka; Koistinaho, Jari; Koivunen, Peppi; Myllyharju, Johanna, 2022, Journal of biological chemistry, 298, 3, 101721. A1 Journal article (refereed), original research

Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease

Gynther, Mikko; Estrada, Mariana Leal; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Auriola, Seppo; Fricker, Gert; Puris, Elena, 2022, Pharmaceutics, 14, 11, 2438. A1 Journal article (refereed), original research

Metabolomic, Lipidomic and Proteomic Characterisation of Lipopolysaccharide-induced Inflammation Mouse Model

Puris, Elena; Kouřil, Štěpán; Najdekr, Lukáš; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Gómez-Budia, Mireia; Fricker, Gert; Kanninen, Katja M; Malm, Tarja; Friedecký, David; Gynther, Mikko, 2022, Neuroscience, 496, 165-178. A1 Journal article (refereed), original research

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex

Choo, Xin Yi; McInnes, Lachlan E; Grubman, Alexandra; Wasielewska, Joanna M; Belaya, Irina; Burrows, Emma; Quek, Hazel; Martín, Jorge Cañas; Loppi, Sanna; Sorvari, Annika; Rait, Dzhessi; Powell, Andrew; Duncan, Clare; Liddell, Jeffrey R.; Tanila, Heikki; Polo, Jose M; Malm, Tarja; Kanninen, Katja M.; Donnelly, Paul S; White, Anthony R, 2022, International journal of molecular sciences, 23, 18, 10722. A1 Journal article (refereed), original research

Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia

Laitinen, Pia; Väänänen, Mari-Anna; Kolari, Ida-Liisa; Mäkinen, Petri I.; Kaikkonen, Minna U.; Weinberg, Marc S.; Morris, Kevin V.; Korhonen, Paula; Malm, Tarja; Ylä-Herttuala, Seppo; Roberts, Thomas C.; Turunen, Mikko P.; Turunen, Tiia A., 2022, PLoS ONE, 17, 3, e0265948. A1 Journal article (refereed), original research

Sex Differences in Poststroke Inflammation: a Focus on Microglia Across the Lifespan

Ugidos, Irene F; Pistono, Cristiana; Korhonen, Paula; Gómez-Budia, Mireia; Sitnikova, Valeriia; Klecki, Pamela; Stanová, Iveta; Jolkkonen, Jukka; Malm, Tarja, 2022, Stroke, 53, 5, 1500-1509. A2 Review article, Literature review, Systematic review

Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer’s Disease Patients

Lampinen, Riikka; Fazaludeen, Mohammad Feroze; Avesani, Simone; Örd, Tiit; Penttilä, Elina; Lehtola, Juha-Matti; Saari, Toni; Hannonen, Sanna; Saveleva, Liudmila; Kaartinen, Emma; Fernández Acosta, Francisco; Cruz-Haces, Marcela; Löppönen, Heikki; Mackay-Sim, Alan; Kaikkonen, Minna U; Koivisto, Anne M; Malm, Tarja; White, Anthony R; Giugno, Rosalba; Chew, Sweelin; Kanninen, Katja M, 2022, Cells, 11, 4, 676. A1 Journal article (refereed), original research

Subacute inhalation of ultrafine particulate matter triggers inflammation without altering amyloid beta load in 5xFAD mice

Saveleva, Liudmila; Vartiainen, Petra; Górová, Veronika; Chew, Sweelin; Belaya, Irina; Konttinen, Henna; Zucchelli, Martina; Korhonen, Paula; Kaartinen, Emma; Kortelainen, Miika; Lamberg, Heikki; Sippula, Olli; Malm, Tarja; Jalava, Pasi I; Kanninen, Katja M, 2022, Neurotoxicology, 89, 55-66. A1 Journal article (refereed), original research

Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice

Puris, Elena; Jalkanen, Aaro; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko, 2022, Brain disorders, 6, 100035. A1 Journal article (refereed), original research

TUBE Project: Transport-Derived Ultrafines and the Brain Effects

Martikainen, Maria-Viola; Aakko-Saksa, Päivi; van den Broek, Lenie; Cassee, Flemming R; Carare, Roxana O; Chew, Sweelin; Dinnyes, Andras; Giugno, Rosalba; Kanninen, Katja M; Malm, Tarja; Muala, Ala; Nedergaard, Maiken; Oudin, Anna; Oyola, Pedro; Pfeiffer, Tobias V; Rönkkö, Topi; Saarikoski, Sanna; Sandström, Thomas; Schins, Roel PF; Topinka, Jan; Yang, Mo; Zeng, Xiaowen; Westerink, Remco HS; Jalava, Pasi I, 2022, International journal of environmental research and public health, 19, 1, 311. A1 Journal article (refereed), original research

The State of the Art of Piezo1 Channels in Skeletal Muscle Regeneration

Bernareggi, Annalisa; Bosutti, Alessandra; Massaria, Gabriele; Giniatullin, Rashid; Malm, Tarja; Sciancalepore, Marina; Lorenzon, Paola, 2022, International journal of molecular sciences, 23, 12, 6616. A2 Review article, Literature review, Systematic review

The role of the meningeal lymphatic system in local meningeal inflammation and trigeminal nociception

Mikhailov, Nikita; Virenque, Anaïs; Koroleva, Kseniia; Eme-Scolan, Elisa; Teleman, Matei; Abdollahzadeh, Ali; Giniatullina, Raisa; Gafurov, Oleg; Krivoshein, Georgii; Malm, Tarja; Hämäläinen, Riikka H; Sierra, Alejandra; Tohka, Jussi; Rua, Rejane; Noe, Francesco M; Giniatullin, Rashid, 2022, Scientific reports, 12, 1, 8804. A1 Journal article (refereed), original research

"Time window" effect of Yoda1-evoked Piezo1 channel activity during mouse skeletal muscle differentiation

Bosutti, Alessandra; Giniatullin, Arthur; Odnoshivkina, Yulia; Giudice, Luca; Malm, Tarja; Sciancalepore, Marina; Giniatullin, Rashid; D'Andrea, Paola; Lorenzon, Paola; Bernareggi, Annalisa, 2021, Acta physiologica, 233, 4, e13702. A1 Journal article (refereed), original research

Additive Behavioral Improvement after Combined Cell Therapy and Rehabilitation Despite Long-Term Microglia Presence in Stroke Rats

Bakreen, Abdulhameed; Juntunen, Miia; Dunlop, Yannick; Ugidos, Irene F.; Malm, Tarja; Miettinen, Susanna; Jolkkonen, Jukka, 2021, International journal of molecular sciences, 22, 4, 1512. A1 Journal article (refereed), original research

Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut

Martiskainen, Henna; Takalo, Mari; Konttinen, Henna; Malm, Tarja; Haapasalo, Annakaisa; Leinonen, Ville; Hiltunen, Mikko, 2021, Duodecim, 137, 13, 1375- 1382. A2 Review article, Literature review, Systematic review

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

Keuters, Meike Hedwig; Keksa-Goldsteine, Velta; Dhungana, Hiramani; Huuskonen, Mikko T; Pomeshchik, Yuriy; Savchenko, Ekaterina; Korhonen, Paula K; Singh, Yajuvinder; Wojciechowski, Sara; Lehtonen, ¦árka; Kanninen, Katja M; Malm, Tarja; Sirviö, Jouni; Muona, Anu; Koistinaho, Milla; Goldsteins, Gundars; Koistinaho, Jari, 2021, Scientific reports, 11, 1, 3518. A1 Journal article (refereed), original research

Extracellular Vesicles from Human Teeth Stem Cells Trigger ATP Release and Promote Migration of Human Microglia through P2X4 Receptor/MFG-E8-Dependent Mechanisms

Jonavice, Ugne; Romenskaja, Diana; Kriauciunaite, Karolina; Jarmalaviciute, Akvile; Pajarskiene, Justina; Ka¨eta, Vytautas; Tunaitis, Virginijus; Malm, Tarja; Giniatulin, Rashid; Pivoriunas, Augustas, 2021, International journal of molecular sciences, 22, 20, 10970. A1 Journal article (refereed), original research

Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays

Pelkonen, Anssi; Pistono, Cristiana; Klecki, Pamela; Gómez-Budia, Mireia; Dougalis, Antonios; Konttinen, Henna; Stanová, Iveta; Fagerlund, Ilkka; Leinonen, Ville; Korhonen, Paula; Malm, Tarja, 2021, Cells, 2022; 11, 1, 106. A2 Review article, Literature review, Systematic review

Glia-Derived Extracellular Vesicles: Role in Central Nervous System Communication in Health and Disease

Pistono, Cristiana; Bister, Nea; Stanová, Iveta; Malm, Tarja, 2021, Frontiers in cell and developmental biology, 8, 623771. A2 Review article, Literature review, Systematic review

High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis

Sturchio, Andrea; Dwivedi, Alok K.; Young, Christina B.; Malm, Tarja; Marsili, Luca; Sharma, Jennifer S.; Mahajan, Abhimanyu; Hill, Emily J.; Andaloussi, Samir EL; Poston, Kathleen L.; Manfredsson, Fredric P.; Schneider, Lon S.; Ezzat, Kariem; Espay, Alberto J., 2021, EClinicalMedicine, 38, 100988. A1 Journal article (refereed), original research

Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice

Puris, Elena; Kouril, ¦tepán; Najdekr, Luká¨; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Friedecký, David; Gynther, Mikko, 2021, Scientific reports, 11, 1, 13076. A1 Journal article (refereed), original research

Microglia Development and Maturation and Its Implications for Induction of Microglia-Like Cells from Human iPSCs

Wurm, Johannes; Konttinen, Henna; Andressen, Christian; Malm, Tarja; Spittau, Björn, 2021, International journal of molecular sciences, 22, 6, 3088. A2 Review article, Literature review, Systematic review

Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids

Fagerlund, Ilkka; Dougalis, Antonios; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Pelkonen, Anssi; Konttinen, Henna; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Koskuvi, Marja; Kuusisto, Johanna; Hernández, Damián; Pebay, Alice; Koistinaho, Jari; Rauramaa, Tuomas; Lehtonen, ¦árka; Korhonen, Paula; Malm, Tarja, 2021, Cells, 2022; 11, 1, 124. A1 Journal article (refereed), original research

Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease

Belaya, Irina; Kucháriková, Nina; Górová, Veronika; Kysenius, Kai; Hare, Dominic J.; Crouch, Peter J.; Malm, Tarja; Atalay, Mustafa; White, Anthony R.; Liddell, Jeffrey R.; Kanninen, Katja M., 2021, International journal of molecular sciences, 22, 16, 8715. A1 Journal article (refereed), original research

Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS). Exercise training intervention in monozygotic twins discordant for body weight

Heiskanen, Marja A; Honkala, Sanna M; Hentilä, Jaakko; Ojala, Ronja; Lautamäki, Riikka; Koskensalo, Kalle; Lietzen, Martin S; Saunavaara, Virva; Saunavaara, Jani; Helmio, Mika; Löyttyniemi, Eliisa; Nummenmaa, Lauri; Collado, Maria C; Malm, Tarja; Lahti, Leo; Pietiläinen, Kirsi H; Kaprio, Jaakko; Rinne, Juha O; Hannukainen, Jarna C, 2021, BMC sports science, medicine & rehabilitation, 13, 1, 16. A1 Journal article (refereed), original research

Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model

Puris, Elena; Auriola, Seppo; Korhonen, Paula; Loppi, Sanna; Kanninen, Katja M; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko, 2021, Journal of pharmaceutical sciences, 110, 12, 3953-3962. A1 Journal article (refereed), original research

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease

Belaya, Irina; Ivanova, Mariia; Sorvari, Annika; Ilicic, Marina; Loppi, Sanna; Koivisto, Hennariikka; Varricchio, Alessandra; Tikkanen, Heikki; Walker, Frederick R; Atalay, Mustafa; Malm, Tarja; Grubman, Alexandra; Tanila, Heikki; Kanninen, Katja M, 2020, Journal of neuroinflammation, 17, 1, 271. A1 Journal article (refereed), original research

Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy

Carare, RO; Aldea, R; Agarwal, N; Bacskai, BJ; Bechman, I; Boche, D; Bu, G; Bulters, D; Clemens, A; Counts, SE; de Leon, M; Eide, PK; Fossati, S; Greenberg, SM; Hamel, E; Hawkes, CA; Koronyo-Hamaoui, M; Hainsworth, AH; Holtzman, D; Ihara, M; et al [incl. Kanninen, K; Leinonen, V; Malm, T], 2020, Alzheimer's & dementia : diagnosis, assessment & disease monitoring, 21, 1, e12053. A1 Journal article (refereed), original research

Disentangling the Amyloid Pathways: A Mechanistic Approach to Etiology

Malmberg, Maja; Malm, Tarja; Gustafsson, Oskar; Sturchio, Andrea; Graff, Caroline; Espay, Alberto J; Wright, Anthony P; El Andaloussi, Samir; Lindén, Anders; Ezzat, Kariem, 2020, Frontiers in neuroscience, 14, 256. A1 Journal article (refereed), original research

Does Cholinergic Stimulation Affect the P2X7 Receptor-Mediated Dye Uptake in Mast Cells and Macrophages?

Nurkhametova, Dilyara; Siniavin, Andrei; Streltsova, Maria; Kudryavtsev, Denis; Kudryavtsev, Igor; Giniatullina, Raisa; Tsetlin, Victor; Malm, Tarja; Giniatullin, Rashid, 2020, Frontiers in cellular neuroscience, 14, 548376. A1 Journal article (refereed), original research

Editorial: Air Pollution and Brain Health

White, Anthony; Kanninen, Katja; Malm, Tarja; Schins, Roel, 2020, Neurochemistry international, 141, 104900. B1 Non-refereed journal articles

Glial smog: Interplay between air pollution and astrocyte-microglia interactions

Gómez-Budia, Mireia; Konttinen, Henna; Saveleva, Liudmila; Korhonen, Paula; Jalava, Pasi; Kanninen, Katja; Malm, Tarja, 2020, Neurochemistry international, 136, 104715. A2 Review article, Literature review, Systematic review

Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions

Bister, Nea; Pistono, Cristiana; Huremagic, Benjamin; Jolkkonen, Jukka; Giugno, Rosalba; Malm, Tarja, 2020, Journal of extracellular vesicles, 10, 1, e12002. A2 Review article, Literature review, Systematic review

Impairment of mitochondrial function by particulate matter: Implications for the brain

Chew, S; Kolosowska, N; Saveleva, L; Malm, T; Kanninen, KM, 2020, Neurochemistry international, 135, 104694. A2 Review article, Literature review, Systematic review

Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation

Kolosowska, Natalia; Gotkiewicz, Maria; Dhungana, Hiramani; Giudice, Luca; Giugno, Rosalba; Box, Daphne; Huuskonen, Mikko T.; Korhonen, Paula; Scoyni, Flavia; Kanninen, Katja M.; Ylä-Herttuala, Seppo; Turunen, Tiia A.; Turunen, Mikko P.; Koistinaho, Jari; Malm, Tarja, 2020, Journal of neuroinflammation, 17, 194. A1 Journal article (refereed), original research

Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals

Loppi, Sanna; Korhonen, Paula; Bouvy-Liivrand, Maria; Cagliola, Simone; Turunen, Tiia A; Turunen, Mikko P; Hernandez de Sande, Ana; Kolosowska, Natalia; Scoyni, Flavia; Rosell, Anna; García-Berrocoso, Teresa; Lemarchant, Sighild; Dhungana, Hiramani; Montaner, Joan; Koistinaho, Jari; Kanninen, Katja M; Kaikkonen, Minna U; Giugno, Rosalba; Heinäniemi, Merja; Malm, Tarja, 2020, Aging cell, 2021; 20, 1, e13287. A1 Journal article (refereed), original research

Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells

Chew, Sweelin; Lampinen, Riikka; Saveleva, Liudmila; Korhonen, Paula; Mikhailov, Nikita; Grubman, Alexandra; Polo, Jose M; Wilson, Trevor; Komppula, Mika; Rönkkö, Teemu; Gu, Cheng; Mackay-Sim, Alan; Malm, Tarja; White, Anthony R; Jalava, Pasi; Kanninen, Katja M, 2020, Particle and fibre toxicology, 17, 1, 18. A1 Journal article (refereed), original research

Activation of P2X7 Receptors in Peritoneal and Meningeal Mast Cells Detected by Uptake of Organic Dyes: Possible Purinergic Triggers of Neuroinflammation in Meninges

Nurkhametova, Dilyara; Kudryavtsev, Igor; Guselnikova, Valeriia; Serebryakova, Maria; Giniatullina, Raisa R; Wojciechowski, Sara; Tore, Fatma; Rizvanov, Albert; Koistinaho, Jari; Malm, Tarja; Giniatullin, Rashid, 2019, Frontiers in cellular neuroscience, 13, 45. A1 Journal article (refereed), original research

Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress

Turunen, TA; Roberts, TC; Laitinen, P; Väänänen, MA; Korhonen, P; Malm, T; Ylä-Herttuala, S; Turunen, M, 2019, Scientific reports, 9, 10332. A1 Journal article (refereed), original research

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis

Korhonen, P; Pollari, E; Kanninen, KM; Savchenko, E; Lehtonen, ¦; Wojciechowski; S; Pomeshchik, Y; Van Den Bosch, L; Goldsteins, G; Koistinaho, J; Malm, T, 2019, IBRO reports, 6, 74-86. A1 Journal article (refereed), original research

Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice

Singh, Y; Leinonen, H; Fazaludeen, F; Jaronen, M; Guest, D; Buckley, N; Byts, N; Oksa, P; Jalkanen, K; Iqbal, I; Huuskonen, M; Savchenko, E; Keksa-Goldsteine, V; Chew, S; Myllyharju, J; Tanila, H; Ooi, L; Koistinaho, J; Kanninen, KM; Malm, T, 2019, Human molecular genetics, 28, 11, 3309-3322. A1 Journal article (refereed), original research

Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine?

Mikhailov, N; Leskinen, J; Fagerlund, I; Poguzhelskaya, E; Giniatullina, R; Gafurov, O; Malm, T; Karjalainen, T; Gröhn, O; Giniatullin, R, 2019, Neuropharmacology, 149, 113-123. A1 Journal article (refereed), original research

Meningeal Mast Cells Contribute to ATP-Induced Nociceptive Firing in Trigeminal Nerve Terminals: Direct and Indirect Purinergic Mechanisms Triggering Migraine Pain

Koroleva, Ksenia; Gafurov, Oleg; Guselnikova, Valeriia; Nurkhametovez, Dilyara; Giniatullina, Raisa; Sitdikova, Guzel; Mattila, Olli S; Lindsberg, Perttu J; Malm, Tarja Maarit; Giniatullin, Rashid, 2019, Frontiers in cellular neuroscience, 13, 195. A1 Journal article (refereed), original research

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Konttinen, H; Cabral-da-Silva, MEC; Ohtonen, S; Wojciechowski, S; Shakirzyanova, A; Caligola, S; Giugno, R; Ishchenko, Y; Hernández, D; Fazaludeen, MF; Eamen, S; Budia, MG; Fagerlund, I; Scoyni, F; Korhonen, P; Huber, N; Haapasalo, A; Hewitt, AW; Vickers, J; Smith, GC; et al., 2019, Stem cell reports, 13, 4, 669-683. A1 Journal article (refereed), original research

Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke

Kolosowska, N; Keuters, MH; Wojciechowski, S; Keksa-Goldsteine, V; Laine, M; Malm, T; Goldsteins, G; Koistinaho, J; Dhungana, H, 2019, Neurotherapeutics, 16, 1304-1319. A1 Journal article (refereed), original research

Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion

Katisko, K; Solje, E; Korhonen, P; Jääskeläinen, O; Loppi, S; Hartikainen, P; Koivisto, AM; Kontkanen, A; Korhonen, VE; Helisalmi, S; Malm, T; Herukka, SK; Remes, AM; Haapasalo, A, 2019, Journal of neurology, 2020; 267, 76-86. A1 Journal article (refereed), original research

The viral protein corona directs viral pathogenesis and amyloid aggregation

Ezzat, K; Pernemalm, M; Pålsson, S; Roberts, TC; Järver, P; Dondalska, A; Bestas, B; Sobkowiak, MJ; Levänen, B; Sköld, M; Thompson, EA; Saher, O; Kari, OK; Lajunen, T; Sverremark Ekström, E; Nilsson, C; Ishchenko, Y; Malm, T; Wood, MJA; Power, UF; et al., 2019, Nature communications, 10, 1, 2331. A1 Journal article (refereed), original research

3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases

Korhonen, Paula; Malm, Tarja; White, Anthony R, 2018, Neurochemistry international, 120, 191-199. A1 Journal article (refereed), original research

8th Kuopio Alzheimer Symposium From translational research to biomarkers, treatment and prevention strategies

Malm, Tarja; Trevisan, Davide, 2018, Itä-Suomen yliopisto. D6 Edited professional book

CuII(atsm) Attenuates Neuroinflammation

Choo, Xin Yi; Liddell, Jeffrey R; Huuskonen, Mikko T; Grubman, Alexandra; Moujalled, Diane; Roberts, Jessica; Kysenius, Kai; Patten, Lauren; Quek, Hazel; Oikari, Lotta E; Duncan, Clare; James, Simon A; McInnes, Lachlan E; Hayne, David J; Donnelly, Paul S; Pollari, Eveliina; Vähätalo, Suvi; Lejavová, Katarína; Kettunen, Mikko I; Malm, Tarja; et al. [Incl Koistinaho, Jari; Kanninen, Katja], 2018, Frontiers in neuroscience, 12, 668. A1 Journal article (refereed), original research

Genotyping and Frequency of PCSK9 Variations Among Hypercholesterolemic and Diabetic Subjects

Nuglozeh, Edem; Feroze Fazaludeen, Mohammad; Hasona, Nabil; Malm, Tarja; Mayor, Luisito B; Al-Hazmi, Awdah; Ashankyty, Ibraheem, 2018, Indian Journal of Clinical Biochemistry, 2019; 34, 4, 444-450. B1 Non-refereed journal articles

HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage

Loppi, S; Kolosowska, N; Kärkkäinen, O; Korhonen, P; Huuskonen, M; Grubman, A; Dhungana, H; Wojciechowski, S; Pomeshchik, Y; Giordano, M; Kagechika, H; White, A; Auriola, S; Koistinaho, J; Landreth, G; Hanhineva, K; Kanninen, K; Malm, T, 2018, Brain behavior and immunity, 73, 670-681. A1 Journal article (refereed), original research

Mitochondrial Function in Alzheimer's Disease: Focus on Astrocytes

Lampinen, Riikka; Belaya, Irina; Boccuni, Isabella; Malm, Tarja; Kanninen, Katja M, 2018, Gentile, Maria Teresa, Astrocyte: Physiology and Pathology, 139-162. A3 Book section, Chapters in research books

PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes

Konttinen, H; Gureviciene, I; Oksanen, M; Grubman, A; Loppi, S; Huuskonen, MT; Korhonen, P; Lampinen, R; Keuters, M; Belaya, I; Tanila, H; Kanninen, KM; Goldsteins, G; Landreth, G; Koistinaho, J; Malm, T, 2018, Glia, 2019; 67, 1, 146-159. A1 Journal article (refereed), original research

Purinergic Profiling of Regulatory T-cells in Patients With Episodic Migraine

Nurkhametova, Dilyara; Kudryavtsev, Igor; Khayrutdinova, Olga; Serebryakova, Maria; Altunbaev, Rashid; Malm, Tarja; Giniatullin, Rashid, 2018, Frontiers in cellular neuroscience, 12, 326. A1 Journal article (refereed), original research

Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein

Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A, 2018, Journal of comparative neurology, 526, 11, 1806-1819. A1 Journal article (refereed), original research

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

Abdalkader, Moataz; Lampinen, Riikka; Kanninen, Katja M; Malm, Tarja M; Liddell, Jeffrey R, 2018, Frontiers in neuroscience, 12, 466. A2 Review article, Literature review, Systematic review

Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist

Gynther M, Proietti Silvestri I, Hansen JC, Hansen KB, Malm T, Ishchenko Y, Larsen Y, Han L, Kayser S, Auriola S, Petsalo A, Nielsen B, Pickering DS, Bunch L, 2017, Journal of medicinal chemistry, 60, 23, 9885-9904. A1 Journal article (refereed), original research

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death

Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M, 2017, Journal of neuroinflammation, 14, 215. A1 Journal article (refereed), original research

Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease

Vellonen KS, Ihalainen J, Boucau M-C, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M, 2017, Pharmaceutical research, 34, 12, 2652-2662. A1 Journal article (refereed), original research

Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy

Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatilloa O, Sallinen J, Ndode-Ekanea XE, Pitkänen A, 2017, Epilepsy research, 136, 18-34. A1 Journal article (refereed), original research

Lack of collagen XV is protective after ischemic stroke in mice

Dhungana Hiramani, Huuskonen Mikko T, Pihlajaniemi Taina, Heljasvaara Ritva, Vivien Denis, Kanninen Katja M, Malm Tarja, Koistinaho Jari, Lemarchant Sighild, 2017, Cell death and disease, 8, January, 1-8. A1 Journal article (refereed), original research

Loss of CLN5 causes altered neurogenesis in a childhood neurodegenerative disorder

Savchenko E, Singh Y, Konttinen H, Lejavova K, Mediavilla Santos L, Grubman A, Kärkkäinen V, Keksa-Goldsteine V, Naumenko N, Tavi P, White AR, Malm TM, Koistinaho J, Kanninen KM, 2017, Disease models and mechanisms, 10, 9, 1089-1100. A1 Journal article (refereed), original research

Metals and lysosomal storage disorders

Konttinen Henna, Lejavová Katarína, Malm Tarja, Kanninen Katja M, 2017, White Anthony R, Aschner Michael, Costa Lucio G, Bush Ashley I, Biometals in neurodegenerative diseases : mechanisms and therapeutics, 195-215. A3 Book section, Chapters in research books

Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease

Mariani MM, Malm T, Lamb R, Jay TR, Neilson L, Casali B, Medarametla L, Landreth GE, 2017, Scientific reports, 7, 42270. A1 Journal article (refereed), original research

Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's diseasethe emerging role for microglia?

Piirainen S, Youssef A, Song C, Kalueff AV, Landreth GE, Malm T, Tian L, 2017, Neuroscience and biobehavioral reviews, 77, 148-164. A2 Review article, Literature review, Systematic review

Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy

Leinonen Henri, Keksa-Goldsteine Velta, Ragauskas Symantas, Kohlmann Philip, Signh Yajuvinder, Savchencko Ekaterina, Puranen Jooseppi, Malm Tarja, Kalesnykas Giedrius, Koistinaho Jari, Tanila Heikki, Kanninen Katja M, 2017, Scientific reports, 7, 1597. A1 Journal article (refereed), original research

Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation

Dhungana H, Huuskonen MT, Jaronen M, Lemarchant S, Ali H, Keksa-Goldsteine V, Goldsteins G, Kanninen KM, Koistinaho J, Malm T, 2017, Journal of neuroinflammation, 14, 11, 237. A1 Journal article (refereed), original research

The Copper bis(thiosemicarbazone) Complex Cu(II)(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu

Huuskonen, MT; Tuo, QZ; Loppi, S; Dhungana, H; Korhonen, P; McInnes, LE; Donnelly, PS; Grubman, A; Wojciechowski, S; Lejavova, K; Pomeshchik, Y; Periviita, L; Kosonen, L; Giordano, M; Walker, FR; Liu, R; Bush, AI; Koistinaho, J; Malm, T; White, AR; et al., 2017, Neurotherapeutics, 14, 2, 519-532. A1 Journal article (refereed), original research

ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J, 2016, Molecular neurodegeneration, 11, 10. A1 Journal article (refereed), original research

Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke

Lemarchant S, Dunghana H, Pomeshchik Y, Leinonen H, Kolosowska N, Korhonen P, Kanninen KM, García-Berrocoso T, Montaner J, Malm T, Koistinaho J, 2016, Glia, 64, 9, 1492-507. A1 Journal article (refereed), original research

Aß and Inflammatory Stimulus Activate Diverse Signaling Pathways in Monocytic Cells: Implications in Retaining Phagocytosis in Aß-Laden Environment

Savchenko Ekaterina, Malm Tarja, Konttinen Henna, Hämäläinen Riikka H, Guerrero-Toro Cindy, Wojciechowski Sara, Giniatullin Rashid, Koistinaho Jari, Magga Johanna, 2016, Frontiers in cellular neuroscience, 10, 279. A1 Journal article (refereed), original research

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy

Huuskonen MT, Loppi S, Dhungana H, Keksa-Goldsteine V, Lemarchant S, Korhonen P, Wojciechowski S, Pollari E, Valonen P, Koponen J, Takashima A, Landreth G, Goldsteins G, Malm T, Koistinaho J, Kanninen KM, 2016, Scientific reports, 6, 33176. A1 Journal article (refereed), original research

Eksosomit aivosairauksissa - solujenvälisen kommunikoinnin uusi muoto

Kanninen K, Malm T, 2016, Duodecim, 132, 21, 1957-63. A1 Journal article (refereed), original research

Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J, 2016, Molecular neurodegeneration, 11, 15. A1 Journal article (refereed), original research

Exosomes in Alzheimer's disease

Malm Tarja, Loppi Sanna, Kanninen Katja M, 2016, Neurochemistry international, 97, 193-199. A1 Journal article (refereed), original research

Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets

Grubman Alexandra, Kanninen Katja M, Malm Tarja, 2016, Journal of molecular neuroscience, 60, 3, 390-404. A1 Journal article (refereed), original research

Pro-nociceptive migraine mediator CGRP provides neuroprotection of sensory, cortical and cerebellar neurons via multi-kinase signaling

Abushik PA, Bart G, Korhonen P, Leinonen H, Giniatullina R, Sibarov DA, Levonen A-L , Malm T, Antonov SM, Giniatullin R, 2016, Cephalalgia, 2017; 37, 14, 1373-1383. A1 Journal article (refereed), original research

Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes

Liddell Jeffrey R, Lehtonen Sarka, Duncan Clare, Keksa-Goldsteine Velta, Levonen Anna-Liisa, Goldsteins Gundars, Malm Tarja, White Anthony R, Koistinaho Jari, Kanninen Katja M, 2016, Journal of neuroinflammation, 13, 49, 1-14. A1 Journal article (refereed), original research

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke

Maysami Samaneh, Wong Raymond, Pradillo Jesus M, Denes Adam, Dhungana Hiramani, Malm Tarja, Koistinaho Jari, Orset Cyrille, Rahman Mahbubur, Rubio Marina, Schwaninger Markus, Vivien Denis, Bath Philip M, Rothwell Nancy J, Allan Stuart M, 2015, Journal of cerebral blood flow and metabolism, [epub ahead of print Sep 30, 2015]. A1 Journal article (refereed), original research

Activation of the nuclear receptor PPARdelta is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammation

Malm Tarja, Mariani Monica, Donovan Lauren J, Neilson Lee, Landreth Gary E, 2015, Journal of neuroinflammation, 12, 7, 15 p. A1 Journal article (refereed), original research

Applications of the Keap1-Nrf2 system for gene and cell therapy

Kanninen Katja M, Pomeshchik Yuriy, Leinonen Hanna, Malm Tarja, Koistinaho Jari, Levonen Anna-Liisa, 2015, Free radical biology and medicine, 88, Part B, 350-361. A2 Review article, Literature review, Systematic review

Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage

Rolova Taisia, Dhungana Hiramani, Korhonen Paula, Valonen Piia, Kolosowska Natalia, Konttinen Henna, Kanninen Katja, Tanila Heikki, Malm Tarja, Koistinaho Jari, 2015, Aging and disease, [epub ahead of print 3 Dec 2015]. A1 Journal article (refereed), original research

Exosomes as new diagnostic tools in CNS diseases

Kanninen Katja M, Bister Nea, Koistinaho Jari, Malm Tarja, 2015, Biochimica et biophysica acta: molecular basis of disease, 2016; 1862, 3, 403-410. A2 Review article, Literature review, Systematic review

Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation

Korhonen Paula, Kanninen Katja M, Lehtonen Sarka, Lemarchant Sighild, Puttonen Katja A, Oksanen Minna, Dhungana Hiramani, Loppi Sanna, Pollari Eveliina, Wojciechowski Sara, Kidin Iurii, Garcia-Berrocoso Teresa, Giralt Dolors, Montaner Joan, Koistinaho Jan I, Malm Tarja, 2015, Brain behavior and immunity, 49, 322-336. A1 Journal article (refereed), original research

Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease

Savage Julie C, Jay Taylor, Goduni Elanda, Quigley Caitlin, Mariani Monica M, Malm Tarja, Ransohoff Richard M, Lamb Bruce T, Landreth Gary E, 2015, Journal of neuroscience, 35, 16, 6532-6543. A1 Journal article (refereed), original research

Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury

Pomeshchik Y, Kidin I, Korhonen P, Savchenko E, Jaronen M, Lehtonen S, Wojciechowski S, Kanninen K, Koistinaho J, Malm T, 2014, Brain behavior and immunity, 2014 Aug 18 ePub ahead of print. A1 Journal article (refereed), original research

Nrf2 regulates neurogenesis and protects neural progenitor cells against aß toxicity

Kärkkäinen Virve, Pomeshchik Yuriy, Savchenko Ekaterina, Dhungana Hiramani, Kurronen Antti, Lehtonen Sarka, Naumenko Nikolay, Tavi Pasi, Levonen Anna-Liisa, Yamamoto Masayaki, Malm Tarja, Magga Johanna, Kanninen Katja M, Koistinaho Jari, 2014, Stem cells, 32, 7, 1904-1916. A1 Journal article (refereed), original research

Nuclear receptors in neurodegenerative diseases

Skerrett R, Malm T, Landreth G, 2014, Neurobiology of disease, 72, Part A, 104-116. A2 Review article, Literature review, Systematic review

Susceptibility to focal and global brain ischemia of Alzheimer mice displaying aß deposits: effect of immunoglobulin

Heikkinen Riikka, Malm Tarja, Heikkilä Janne, Muona Anu, Tanila Heikki, Koistinaho Milla, Koistinaho Jari, 2014, Aging and disease, 2014 Apr 1;5(2), 76-87. A1 Journal article (refereed), original research

The Evolving Biology of Microglia in Alzheimer's Disease

Malm Tarja M, Jay Taylor R, Landreth Gary E, 2014, Neurotherapeutics, -, 2014 Nov 18. [Epub ahead of print]. A2 Review article, Literature review, Systematic review

Transplanted human iPSC-derived neural progenitor cells do not promote functional recovery of pharmacologically immunosuppressed mice with contusion spinal cord injury

Pomeshchik Y, Puttonen KA, Kidin I, Ruponen M, Lehtonen S, Malm T, Akesson E, Hovatta O, Koistinaho J, 2014, Cell transplantation, 2014 Sep 8. [Epub ahead of print]. A1 Journal article (refereed), original research

Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection

Dhungana H, Malm T, Denes A, Valonen P, Wojciechowski S, Magga J, Savchenko E, Humphreys N, Grencis R, Rothwell N, Koistinaho J, 2013, Aging cell, 2013 Jun 3. (Epub ahead of print). A1 Journal article (refereed), original research

Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit

Rolova T, Puli L, Magga J, Dhungana H, Kanninen K, Wojciehowski S, Salminen A, Tanila H, Koistinaho J, Malm T, 2013, Neurobiology of disease, [Epub ahead of print], 64C, 16-29. A1 Journal article (refereed), original research

Does Nrf2 Gene Transfer Facilitate Recovery After Contusion Spinal Cord Injury?

Pomeshchik Y, Kidin I, Savchenko E, Rolova T, Yamamoto M, Levonen AL, Ylä-Herttuala S, Malm T, Kanninen K, Koistinaho J, 2013, Antioxidants and redox signaling, 2013 Aug 20. [Epub ahead of print], x-x. A1 Journal article (refereed), original research

Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele

Dhungana H, Rolova T, Savchenko E, Wojciechowski S, Savolainen K, Ruotsalainen AK, Sullivan PM, Koistinaho J, Malm T, 2013, Journal of neuroinflammation, 2013 Aug 20;10(1):102. A1 Journal article (refereed), original research

Animal Models of Alzheimer's Disease: Utilization of Transgenic Alzheimer's Disease Models in Studies of Amyloid Beta Clearance

Malm T, Magga J, Koistinaho J, 2012, Current translational geriatrics and experimental gerontology reports, - -. A1 Journal article (refereed), original research

Brain Environment and Alzheimer's Disease Mutations Affect the Survival, Migration and Differentiation of Neural Progenitor Cells

Kärkkäinen V, Magga J, Koistinaho J, Malm T, 2012, Current alzheimer research, 2012 Aug 30. [Epub ahead of print]. A1 Journal article (refereed), original research

Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer's disease

Puli L, Pomeshchik Y, Olas K, Malm T, Koistinaho J, Tanila H, 2012, Journal of neuroinflammation, 2012 May 29;9:105. A1 Journal article (refereed), original research

Production of monocytic cells from bone marrow stem cells: therapeutic usage in Alzheimer's disease

Magga J, Savchenko E, Malm T, Rolova T, Pollari E, Valonen P, Lehtonen S, Jantunen E, Aarnio J, Lehenkari P, Koistinaho M, Muona A, Koistinaho J, 2012, Journal of cellular and molecular medicine, 2012 May;16(5), 1060-73. A1 Journal article (refereed), original research

Protein Disulfide Isomerase in ALS Mouse Glia Links Protein Misfolding with NADPH Oxidase Catalyzed Superoxide Production

Jaronen M, Vehviläinen P, Malm T, Keksa-Goldsteine V, Pollari E, Valonen P, Koistinaho J, Goldsteins G, 2012, Human molecular genetics, 2012 Nov 1. [Epub ahead of print]. A1 Journal article (refereed), original research

Glycogen synthase kinase-3&#946 : a mediator of inflammation in Alzheimer's disease?

Koistinaho J, Malm T, Goldsteins G, 2011, International journal of alzheimers disease, 2011;2011:129753. Epub 2011 May 4. A2 Review article, Literature review, Systematic review

Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis

Pollari Eveliina, Savchenko Ekaterina, Jaronen Merja, Kanninen Katja, Malm Tarja, Wojciechowski Sara, Ahtoniemi Toni, Goldsteins Gundars, Giniatullina Raisa, Giniatullin Rashid, Koistinaho Jari, Magga Johanna, 2011, Journal of neuroinflammation, 84, 1-14. A1 Journal article (refereed), original research

Targeting Glycogen Synthase Kinase-3&#946 for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway

Kanninen K, White AR, Koistinaho J, Malm T, 2011, International journal of alzheimers disease, 2011;2011:985085. Epub 2011 May 2. A2 Review article, Literature review, Systematic review

Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer's Disease: Focus on Gene Therapy and Cell-Based Therapy Applications

Malm T, Koistinaho J, Kanninen K, 2011, International journal of alzheimers disease, 2011;2011:517160. Epub 2011 Oct 30. A2 Review article, Literature review, Systematic review

The role and therapeutic potential of monocytic cells in Alzheimer's disease

Malm T, Koistinaho M, Muona A, Magga J & Koistinaho J, 2010, Glia, 58, 8, 889-900. A1 Journal article (refereed), original research

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J, 2009, Proceedings of the National Academy of Sciences of the United States of America, 106, 38, 16505-16510. A1 Journal article (refereed), original research

Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice

Minkeviciene R, Ihalainen J, Malm T, Matilainen O, Keksa-Goldsteine V, Goldsteins G, Iivonen H, Leguit N, Glennon J, Koistinaho J, Banerjee P, Tanila H, 2008, Journal of neurochemistry, 105, 584-594. A1 Journal article (refereed), original research

Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210

Pulkkinen K, Malm T, Turunen M, Koistinaho J, Ylä-Herttuala S, 2008, Febs letters, 582, 2397-2401. A1 Journal article (refereed), original research

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid

Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J, 2008, Molecular and cellular neuroscience, 39, 3, 302-313. A1 Journal article (refereed), original research

Transplanted astrocytes internalize deposited beta-amyloid peptides in a transgenic mouse model of Alzheimer's disease

Pihlaja R, Koistinaho J, Malm T, Sikkilä H, Vainio S, Koistinaho M, 2008, Glia, 56, 154-163. A1 Journal article (refereed), original research

Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden

Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J, 2007, Journal of neuroscience, 27, 14, 3712-3721. A1 Journal article (refereed), original research

Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis

Ahtoniemi T, Goldsteins G, Keksa-Goldsteine V, Malm T, Kanninen K, Salminen A, Koistinaho J, 2007, Molecular pharmacology, 71, 30-37. A1 Journal article (refereed), original research

Beta-amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits

Malm T, Ort M, Tähtivaara L, Jukarainen N, Goldsteins G, Puoliväli J, Nurmi A, Pussinen R, Ahtoniemi T, Miettinen T-K, Kanninen K, Leskinen S, Vartiainen N, Yrjänheikki J, Laatikainen R, Harris-White ME, Koistinaho M, Frautschy SA, Bures J, 2006, Proceedings of the National Academy of Sciences of the United States of America, 103, 23, 8852-8857. A1 Journal article (refereed), original research

Glial Cells in Alzheimer's Disease Models

Malm T, 2006, Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti. G5 Doctoral dissertation (article)

Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain

Mäkinen PI, Koponen JK, Kärkkäinen A-M, Malm TM, Pulkkinen KH, Koistinaho J, Turunen MP, Ylä-Herttuala S, 2006, Journal of gene medicine, 8, 4, 433-441. A1 Journal article (refereed), original research

Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice

Malm TM, Koistinaho M, Pärepalo M, Vatanen T, Ooka A, Karlsson S, Koistinaho J, 2005, Neurobiology of disease, 18, 1, 134-142. A1 Journal article (refereed), original research

Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice

Koistinaho M, Malm TM, Kettunen MI, Goldsteins G, Starckx S, Kauppinen RA, Opdenakker G, Koistinaho J, 2005, Journal of cerebral blood flow and metabolism, 25, 460-467. A1 Journal article (refereed), original research

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Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage

Germinal center trajectories and transcriptional signatures define CLL subtypes and their pathway regulators

Increased activity of Piezo1 channel in red blood cells is associated with Alzheimer's disease-related dementia

Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU-005 reduces ex vivo cortical spreading depression

Microglial involvement in autism spectrum disorder: insights from human data and iPSC models

Mitochondrial and energy metabolism dysfunctions are hallmarks of TDP-43G376D fibroblasts from members of an Amyotrophic Lateral Sclerosis family

Modeling neuroinflammatory interactions between microglia and astrocytes in a human iPSC-based coculture platform

Molecular Determinants of Protein Pathogenicity at the Single‐Aggregate Level

Obesity is associated with increased brain glucose uptake and activity but not neuroinflammation (TSPO availability) in monozygotic twin pairs discordant for BMI—Exercise training reverses increased brain activity

Oxidative modulation of Piezo1 channels

Segment Anything for Dendrites from Electron Microscopy

The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions

Traffic-related diesel pollution particles impair the lysosomal functions of human iPSC-derived microglia

Traffic-related ultrafine particles influence gene regulation in olfactory mucosa cells altering PI3K/AKT signaling

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease

Effects of Obesity and Exercise on Hepatic and Pancreatic Lipid Content and Glucose Metabolism: PET Studies in Twins Discordant for BMI

Emerging Models to Study Human Microglia In vitro

Mechanisms Leading to Increased Insulin-Stimulated Cerebral Glucose Uptake in Obesity and Insulin Resistance: A High-Fat Diet and Exercise Training Intervention PET Study with Rats (CROSRAT)

Particulate matter from car exhaust alters function of human iPSC-derived microglia

Regular Exercise Training Induces More Changes on Intestinal Glucose Uptake from Blood and Microbiota Composition in Leaner Compared to Heavier Individuals in Monozygotic Twins Discordant for BMI

SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion

StellarPath: Hierarchical-vertical multi-omics classifier synergizes stable markers and interpretable similarity networks for patient profiling

Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology

Traffic-related ultrafine particles impair mitochondrial functions in human olfactory mucosa cells – Implications for Alzheimer's disease

Transcriptomic and epigenomic profiling reveals altered responses to diesel emissions in Alzheimer's disease both in vitro and in population-based data

Uptake of alpha‐synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia

ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling

Alzheimer's disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs

Bone marrow metabolism is affected by body weight and response to exercise training varies according to anatomical location

Construction of Fusion Protein for Enhanced Small RNA Loading to Extracellular Vesicles

Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia

Early Alzheimer's disease pathology in human cortex involves transient cell states

Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment

Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function

Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI)

Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation

Transcriptomic Alterations in the Olfactory Bulb Induced by Exposure to Air Pollution: Identification of Potential Biomarkers and Insights into Olfactory System Function

Activation of Meningeal Afferents Relevant to Trigeminal Headache Pain after Photothrombotic Stroke Lesion: A Pilot Study in Mice

Air Pollution Exposure Increases ABCB1 and ASCT1 Transporter Levels in Mouse Cortex

Astrocyte Progenitors Derived From Patients With Alzheimer Disease Do Not Impair Stroke Recovery in Mice

Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease

High Soluble Amyloid-β42 Predicts Normal Cognition in Amyloid-Positive Individuals with Alzheimer’s Disease-Causing Mutations

Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation

Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease

Metabolomic, Lipidomic and Proteomic Characterisation of Lipopolysaccharide-induced Inflammation Mouse Model

Microglia states and nomenclature: A field at its crossroads

Microglial amyloid beta clearance is driven by PIEZO1 channels

Neuron-astrocyte transmitophagy is altered in Alzheimer's disease

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex

Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia

Sex Differences in Poststroke Inflammation: a Focus on Microglia Across the Lifespan

Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer’s Disease Patients

Subacute inhalation of ultrafine particulate matter triggers inflammation without altering amyloid beta load in 5xFAD mice

Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice

TUBE Project: Transport-Derived Ultrafines and the Brain Effects

The State of the Art of Piezo1 Channels in Skeletal Muscle Regeneration

The role of the meningeal lymphatic system in local meningeal inflammation and trigeminal nociception

"Time window" effect of Yoda1-evoked Piezo1 channel activity during mouse skeletal muscle differentiation

Additive Behavioral Improvement after Combined Cell Therapy and Rehabilitation Despite Long-Term Microglia Presence in Stroke Rats

Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

Extracellular Vesicles from Human Teeth Stem Cells Trigger ATP Release and Promote Migration of Human Microglia through P2X4 Receptor/MFG-E8-Dependent Mechanisms

Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays

Glia-Derived Extracellular Vesicles: Role in Central Nervous System Communication in Health and Disease

High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis

Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice

Microglia Development and Maturation and Its Implications for Induction of Microglia-Like Cells from Human iPSCs

Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids

Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease

Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS). Exercise training intervention in monozygotic twins discordant for body weight

Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease

Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy

Disentangling the Amyloid Pathways: A Mechanistic Approach to Etiology