Janne Tampio

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Information Publications

I study the applicability of transporter proteins in drug delivery and targeting. My research expertise includes, e.g., cell culturing, in vitro studies, and mass spectrometry (LC-MS).

Research groups

Keywords

analytical chemistry drug analysis drug delivery drug targeting drug transporters LC-MS mass spectrometry pharmaceutical chemistry pharmacokinetics pharmacy prodrug

Publications

22/22 items

A Novel Tertiary Carbamate Prodrug Strategy to Overcome Metabolic Barriers in Oral Ketamine Delivery
Järvinen, Juulia; Adla, Santosh Kumar; Tampio, Janne; Jalkanen, Aaro; Sloan, Kenneth B; Huttunen, Kristiina M; Rautio, Jarkko, 2026, Chemmedchem, 21, 2, e202500856. A1 Journal article (refereed), original research
Biomimetic porous silicon for rationally designed combination therapy to induce immunogenic cell death
Saarela, Silja; Happonen, Emilia; Laari, Milla-Iida; Sivonen, Minna; Zakir, Mohammed; Saba, Shaghayegh; Tampio, Janne; Liu, Ruixian; Klefström, Juha; Pajula, Katja; Huttunen, Kristiina M; Lehto, Vesa-Pekka; Xu, Wujun, 2026, Nanomedicine: nanotechnology biology and medicine, 74, 102931. A1 Journal article (refereed), original research
A novel paracetamol derivative alleviates lipopolysaccharide-induced neuroinflammation
Králová, Adéla; Montaser, Ahmed B; Tampio, Janne; Adla, Santosh Kumar; Jalkanen, Aaro; Rysä, Jaana; Huttunen, Kristiina M, 2025, European journal of pharmacology, 995, 177409. A1 Journal article (refereed), original research
Amino acid prodrug of capsaicin improves pharmacokinetic properties in the mouse brain and pancreas
Tampio, Janne; Králová, Adéla; Riihioja, Sara; Pitkänen, Sofia; Markowicz-Piasecka, Magdalena; Ihamäki, Olli; Savolainen, Katja; Torunoglu, Sema T; Jalkanen, Aaro J; Lehtonen, Marko; Kauppinen, Anu; Rysä, Jaana; Huttunen, Kristiina M, 2025, European journal of pharmaceutics and biopharmaceutics, 214, 114797. A1 Journal article (refereed), original research
Brain-targeted Jedi1 and Jedi2 derivatives as potent enhancers of Piezo1 ion channel activity
Anamea, Landry; Králová, Adéla; Tampio, Janne; Shakirzyanova, Anastasia; Hänninen, Milka; Giniatullin, Rashid; Jalkanen, Aaro J; Malm, Tarja; Huttunen, Kristiina M, 2025, European journal of medicinal chemistry, 302, Part 2, 118359. A1 Journal article (refereed), original research
Enhanced Polarity of Sulfonamide Metformin Derivatives Increases Cellular Uptake and Apoptosis-Inducing Effects in Human Breast Cancer Cells
Kuorikoski, Ville; Tampio, Janne; Kerachni, Soumeya; Timonen, Daria; Tonduru, Arun Kumar; Markowicz-Piasecka, Magdalena; Terasaki, Tetsuya; Poso, Antti; Huttunen, Kristiina M, 2025, Molecular pharmaceutics, 23, 2, 680-693. A1 Journal article (refereed), original research
Enhancing drug delivery into the pancreas via L-type amino acid transporter 1
Tampio, Janne, 2025, Publications of the University of Eastern Finland. Dissertations in Health Sciences. G5 Doctoral dissertation (article)
Lääkeaineiden "perillesaannin" haasteet ja ratkaisut
Tampio, Janne; Huttunen, Kristiina M., 2025, Tieteessä tapahtuu, 43, 4, 6-11. E1 Popularised article, newspaper article
Asymmetric Synthesis and Biological Evaluation of Both Enantiomers of 5- and 6-Boronotryptophan as Potential Boron Delivery Agents for Boron Neutron Capture Therapy
Retini, Michele; Järvinen, Juulia; Bahrami, Katayun; Tampio, Janne; Bartoccini, Francesca; Riihelä, Petri; Pehkonen, Henna; Värä, Arina; Laitinen, Tuomo; Huttunen, Kristiina M.; Rautio, Jarkko; Piersanti, Giovanni; Timonen, Juri M, 2024, Acs medicinal chemistry letters, 15, 12, 2121-2128. A1 Journal article (refereed), original research
Specific Transport of Temozolomide Does Not Override DNA Repair-mediated Chemoresistance
Bahrami, Katayan; Kärkkäinen, Jussi; Bibi, Sania; Huttunen, Johanna; Tampio, Janne; Montaser, Ahmed B.; Moody, Catherine L; Lehtonen, Marko; Rautio, Jarkko; Wheelhouse, Richard T; Huttunen, Kristiina M, 2024, European journal of pharmaceutical sciences, 195, 106661. A1 Journal article (refereed), original research
The L-type amino acid transporter 1 enhances drug delivery to the mouse pancreatic beta cell line (MIN6)
Tampio, Janne; Montaser, Ahmed B.; Järvinen, Juulia; Lehtonen, Marko; Jalkanen, Aaro J.; Reinisalo, Mika; Kokkola, Tarja; Terasaki, Tetsuya; Laakso, Markku; Rysä, Jaana; Kauppinen, Anu; Huttunen, Kristiina M, 2024, European journal of pharmaceutical sciences, 203, 106937. A1 Journal article (refereed), original research
Amino acid derivative of probenecid potentiates apoptosis-inducing effects of vinblastine by increasing oxidative stress in a cancer cell-specific manner
Huttunen, Johanna; Tampio, Janne; Järvinen, Juulia; Montaser, Ahmed B; Markowicz-Piasecka, Magdalena; Huttunen, Kristiina M, 2023, Chemico-biological interactions, 388, 110833. A1 Journal article (refereed), original research
Metformin derivatives – Researchers’ friends or foes?
Torunoglu, Sema Tuna; Zajda, Agnieszka; Tampio, Janne; Markowicz-Piasecka, Magdalena; Huttunen, Kristiina M, 2023, Biochemical pharmacology, 215, 115743. A2 Review article, Literature review, Systematic review
Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study
Lapatto, Helena A. K.; Kuusela, Minna; Heikkinen, Aino; Muniandy, Maheswary; van der Kolk, Birgitta W.; Gopalakrishnan, Swetha; Pöllänen, Noora; Sandvik, Martin; Schmidt, Mark S.; Heinonen, Sini; Saari, Sina; Kuula, Juho; Hakkarainen, Antti; Tampio, Janne; Saarinen, Tuure; Taskinen, Marja-Riitta; Lundbom, Nina; Groop, Per-Henrik; Tiirola, Marja; Katajisto, Pekka; Lehtonen, Marko; Brenner, Charles; Kaprio, Jaakko; Pekkala, Satu; Ollikainen, Miina; Pietiläinen, Kirsi H.; Pirinen, Eija, 2023, Science advances, 9, 2, 1-23. A1 Journal article (refereed), original research
Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon
Cui, Hengjing; Elford, Joshua D; Alitalo, Okko; Perez-Pardo, Paula; Tampio, Janne; Huttunen, Kristiina M; Kraneveld, Aletta; Forsberg, Markus M; Myöhänen, Timo T; Jalkanen, Aaro J, 2023, Neurobiology of aging, 129, 62-71. A1 Journal article (refereed), original research
Substituent effects of sulfonamide derivatives of metformin that can dually improve cellular glucose utilization and anti-coagulation
Zajda, Agnieszka; Sikora, Joanna; Hynninen, Mira; Tampio, Janne; Huttunen, Kristiina M.; Markowicz-Piasecka, Magdalena, 2023, Chemico-biological interactions, 373, 110381. A1 Journal article (refereed), original research
Targeting Glial Cells by Organic Anion-Transporting Polypeptide 1C1 (OATP1C1)-Utilizing l-Thyroxine-Derived Prodrugs
Tonduru, Arun Kumar; Maljaei, Seyed Hamed; Adla, Santosh Kumar; Anamea, Landry; Tampio, Janne; Králová, Adéla; Jalkanen, Aaro J; Espada, Catarina; Santos, Inês Falcato; Montaser, Ahmed B; Rautio, Jarkko; Kronenberger, Thales; Poso, Antti; Huttunen, Kristiina M, 2023, Journal of medicinal chemistry, 66, 22, 15094-15114. A1 Journal article (refereed), original research
Comparison of Experimental Strategies to Study l-Type Amino Acid Transporter 1 (LAT1) Utilization by Ligands
Huttunen, Johanna; Agami, Mahmoud; Tampio, Janne; Montaser, Ahmed B; Huttunen, Kristiina M, 2022, Molecules, 27, 1, 37. A1 Journal article (refereed), original research
L-type Amino Acid Transporter 1 Utilizing Ferulic Acid Derivatives Show Increased Drug Delivery in the Mouse Pancreas Along with Decreased Lipid Peroxidation and Prostaglandin Production
Tampio, Janne; Markowicz-Piasecka, Magdalena; Montaser, Ahmed; Rysä, Jaana; Kauppinen, Anu; Huttunen, Kristiina M, 2022, Molecular pharmaceutics, 19, 11, 3806-3819. A1 Journal article (refereed), original research
Hemocompatible L-Type amino acid transporter 1 (LAT1)-Utilizing prodrugs of perforin inhibitors can accumulate into the pancreas and alleviate inflammation-induced apoptosis
Tampio, Janne; Markowicz-Piasecka, Magdalena; Huttunen, Kristiina M., 2021, Chemico-biological interactions, 345, 109560. A1 Journal article (refereed), original research
Improved L-Type Amino Acid Transporter 1 (LAT1)-Mediated Delivery of Anti-Inflammatory Drugs into Astrocytes and Microglia with Reduced Prostaglandin Production
Tampio, Janne; Löffler, Susanne; Guillon, Melina; Hugele, Agathe; Huttunen, Johanna; Huttunen, Kristiina M., 2021, International journal of pharmaceutics, 601, 120565. A1 Journal article (refereed), original research
Targeting of Perforin Inhibitor into the Brain Parenchyma Via a Prodrug Approach Can Decrease Oxidative Stress and Neuroinflammation and Improve Cell Survival
Tampio, Janne; Huttunen, Johanna; Montaser, Ahmed; Huttunen, Kristiina M, 2020, Molecular neurobiology, 57, 11, 4563-4577. A1 Journal article (refereed), original research

Refine your search

Research groups

Keywords

A Novel Tertiary Carbamate Prodrug Strategy to Overcome Metabolic Barriers in Oral Ketamine Delivery

Biomimetic porous silicon for rationally designed combination therapy to induce immunogenic cell death

A novel paracetamol derivative alleviates lipopolysaccharide-induced neuroinflammation

Amino acid prodrug of capsaicin improves pharmacokinetic properties in the mouse brain and pancreas

Brain-targeted Jedi1 and Jedi2 derivatives as potent enhancers of Piezo1 ion channel activity

Enhanced Polarity of Sulfonamide Metformin Derivatives Increases Cellular Uptake and Apoptosis-Inducing Effects in Human Breast Cancer Cells

Enhancing drug delivery into the pancreas via L-type amino acid transporter 1

Lääkeaineiden "perillesaannin" haasteet ja ratkaisut

Asymmetric Synthesis and Biological Evaluation of Both Enantiomers of 5- and 6-Boronotryptophan as Potential Boron Delivery Agents for Boron Neutron Capture Therapy

Specific Transport of Temozolomide Does Not Override DNA Repair-mediated Chemoresistance

The L-type amino acid transporter 1 enhances drug delivery to the mouse pancreatic beta cell line (MIN6)

Amino acid derivative of probenecid potentiates apoptosis-inducing effects of vinblastine by increasing oxidative stress in a cancer cell-specific manner

Metformin derivatives – Researchers’ friends or foes?

Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study

Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon

Substituent effects of sulfonamide derivatives of metformin that can dually improve cellular glucose utilization and anti-coagulation

Targeting Glial Cells by Organic Anion-Transporting Polypeptide 1C1 (OATP1C1)-Utilizing l-Thyroxine-Derived Prodrugs

Comparison of Experimental Strategies to Study l-Type Amino Acid Transporter 1 (LAT1) Utilization by Ligands

L-type Amino Acid Transporter 1 Utilizing Ferulic Acid Derivatives Show Increased Drug Delivery in the Mouse Pancreas Along with Decreased Lipid Peroxidation and Prostaglandin Production

Hemocompatible L-Type amino acid transporter 1 (LAT1)-Utilizing prodrugs of perforin inhibitors can accumulate into the pancreas and alleviate inflammation-induced apoptosis

Improved L-Type Amino Acid Transporter 1 (LAT1)-Mediated Delivery of Anti-Inflammatory Drugs into Astrocytes and Microglia with Reduced Prostaglandin Production

Targeting of Perforin Inhibitor into the Brain Parenchyma Via a Prodrug Approach Can Decrease Oxidative Stress and Neuroinflammation and Improve Cell Survival