Henna Martiskainen

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My research is focused on the genetic risk factors for Alzheimer’s disease and other neurodegenerative diseases in the Finnish population. I use human-derived cell models to understand the molecular mechanisms of the genetic risk variants in microglial cells.

Research groups

Molecular Genetics of Alzheimer's Disease - Hiltu… 01.01.2022 -

Keywords

Alzheimer's disease genetics in vitro models microglia neuroscience

Publications

17/17 items

Deep learning assisted quantitative analysis of Aβ and microglia in patients with idiopathic normal pressure hydrocephalus in relation to cognitive outcome
Luikku, Antti J; Nerg, Ossi; Koivisto, Anne M; Hanninen, Tuomo; Junkkari, Antti; Kemppainen, Susanna; Juopperi, Sini-Pauliina; Sinisalo, Rosa; Pesola, Alli; Soininen, Hilkka; Hiltunen, Mikko; Leinonen, Ville; Rauramaa, Tuomas; Martiskainen, Henna. 2024. Journal of neuropathology and experimental neurology. 83: 967-978 A1 Journal article (refereed), original research
Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates
Kemppainen, Susanna; Huber, Nadine; Willman, Roosa-Maria; Zamora, Ana; Makinen, Petra; Martiskainen, Henna; Takalo, Mari; Haapasalo, Annakaisa; Sobrino, Tomas; Gomez, Manuel Antonio Gonzalez; Pineiro, Yolanda; Rivas, Jose; Himmelreich, Uwe; Hiltunen, Mikko. 2023. Cells. 12: A1 Journal article (refereed), original research
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models
Wittrahm, Rebekka; Takalo, Mari; Kuulasmaa, Teemu; Mäkinen, Petra M; Mäkinen, Petri; Končarević, Saša; Fartzdinov, Vadim; Selzer, Stefan; Kokkola, Tarja; Antikainen, Leila; Martiskainen, Henna; Kemppainen, Susanna; Marttinen, Mikael; Jeskanen, Heli; Rostalski, Hannah; Rahunen, Eija; Kivipelto, Miia; Ngandu, Tiia; Natunen, Teemu; Lambert, Jean-Charles; Tanzi, Rudolph E; Kim, Doo Yeon; Rauramaa, Tuomas; Herukka, Sanna-Kaisa; Soininen, Hilkka; Laakso, Markku; Pike, Ian; Leinonen, Ville; Haapasalo, . 2023. Neurobiology of disease. 182: A1 Journal article (refereed), original research
Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut
Martiskainen, Henna; Takalo, Mari; Konttinen, Henna; Malm, Tarja; Haapasalo, Annakaisa; Leinonen, Ville; Hiltunen, Mikko. 2021. Duodecim. 137: 1375- 1382 A2 Review article, Literature review, Systematic review
MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation
Wittrahm, Rebekka; Takalo, Mari; Marttinen, Mikael; Kuulasmaa, Teemu; Mäkinen, Petra; Kemppainen, Susanna; Martiskainen, Henna; Rauramaa, Tuomas; Pike, Ian; Leinonen, Ville; Natunen, Teemu; Haapasalo, Annakaisa; Hiltunen, Mikko. 2021. Cells. 10: 860 A1 Journal article (refereed), original research
Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques
Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, Heikki; Hiltunen, Mikko]. 2020. Molecular neurodegeneration. 15: 66 A1 Journal article (refereed), original research
The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions
Takalo, Mari; Wittrahm, Rebekka; Wefers, Benedikt; Parhizkar, Samira; Jokivarsi, Kimmo; Kuulasmaa, Teemu; Mäkinen, Petra; Martiskainen, Henna; Wurst, Wolfgang; Xiang, Xianyuan; Marttinen, Mikael; Poutiainen, Pekka; Haapasalo, Annakaisa; Hiltunen, Mikko; Haass, Christian. 2020. Molecular neurodegeneration. 15: 52 A1 Journal article (refereed), original research
Altered Insulin Signaling in Alzheimer's Disease Brain - Special Emphasis on PI3K-Akt Pathway
Gabbouj, Sami; Ryhanen, Simo; Marttinen, Mikael; Wittrahm, Rebekka; Takalo, Mari; Kemppainen, Susanna; Martiskainen, Henna; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko; Natunen, Teemu. 2019. Frontiers in neuroscience. 13: 629 A2 Review article, Literature review, Systematic review
Decreased plasma C-reactive protein levels in APOE E 4 allele carriers
Martiskainen, Henna; Takalo, Mari; Solomon, Alina; Stancáková, Alena; Marttinen, Mikael; Natunen, Teemu; Haapasalo, Annakaisa; Herukka, Sanna-Kaisa; Kuusisto, Johanna; Soininen, Hilkka; Kivipelto, Miia; Laakso, Markku; Hiltunen, Mikko. 2018. Annals of clinical and translational neurology. 5: 1229-1240 A1 Journal article (refereed), original research
DHCR24 exerts neuroprotection upon inflammation-induced neuronal death
Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M. 2017. Journal of neuroinflammation. : 215 A1 Journal article (refereed), original research
Decreased plasma ß-amyloid in the Alzheimer's disease APP A673T variant carriers
Martiskainen H, Herukka SK, Stancáková A, Paananen J, Soininen H, Kuusisto J, Laakso M, Hiltunen M. 2017. Annals of neurology. 82: 128-132 A1 Journal article (refereed), original research
Effects of Alzheimer's Disease-Associated Risk Loci on Cerebrospinal Fluid Biomarkers and Disease Progression: A Polygenic Risk Score Approach
Martiskainen Henna, Helisalmi Seppo, Viswanathan Jayashree, Kurki Mitja, Hall Anette, Herukka Sanna-Kaisa, Sarajärvi Timo, Natunen Teemu, Kurkinen Kaisa M.A., Huovinen Jaakko, Mäkinen Petra, Laitinen Marjo, Koivisto Anne M., Mattila Kari M., Lehtimäki Terho, Remes Anne M., Leinonen Ville, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2015. Journal of Alzheimer's disease. 43: 565-573 A1 Journal article (refereed), original research
Polygenic risk scores, transcriptomics, and molecular mechanisms of Alzheimer's disease-related risk genes
Martiskainen Henna. 2015. Publications of the University of Eastern Finland. Dissertations in Health Sciences G5 Doctoral dissertation (article)
High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status
Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. Journal of nutritional biochemistry. 25: 634-641 A1 Journal article (refereed), original research
Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models
Martiskainen H, Viswanathan J, Nykänen NP, Kurki M, Helisalmi S, Natunen T, Sarajärvi T, Kurkinen KM, Pursiheimo JP, Rauramaa T, Alafuzoff I, Jääskeläinen JE, Leinonen V, Soininen H, Haapasalo A, Huttunen HJ, Hiltunen M. 2014. Neurobiology of aging. 36: 1221.e15-1221.e28 A1 Journal article (refereed), original research
Effects of NR1H3 genetic variation on the expression of liver X receptor alfa and the progression of Alzheimer's Disease
Natunen Teemu, Martiskainen Henna, Sarajärvi Timo, Helisalmi Seppo, Pursiheimo Juha-Pekka, Viswanathan Jayashree, Laitinen Marjo, Kauppinen Tarja, Rauramaa Tuomas, Leinonen Ville, Alafuzoff Irina, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2013. PLoS ONE. 8: e80700 A1 Journal article (refereed), original research
Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease
Martiskainen H, Haapasalo A, Kurkinen KM, Pihlajamäki J, Soininen H, Hiltunen M. 2013. Expert opinion on therapeutic targets. 17: 781-794 A1 Journal article (refereed), original research

Refine your search

Research groups

Keywords

Deep learning assisted quantitative analysis of Aβ and microglia in patients with idiopathic normal pressure hydrocephalus in relation to cognitive outcome

Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates

Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut

MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation

Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques

The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions

Altered Insulin Signaling in Alzheimer's Disease Brain - Special Emphasis on PI3K-Akt Pathway

Decreased plasma C-reactive protein levels in APOE E 4 allele carriers

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death

Decreased plasma ß-amyloid in the Alzheimer's disease APP A673T variant carriers

Effects of Alzheimer's Disease-Associated Risk Loci on Cerebrospinal Fluid Biomarkers and Disease Progression: A Polygenic Risk Score Approach

Polygenic risk scores, transcriptomics, and molecular mechanisms of Alzheimer's disease-related risk genes

High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models

Effects of NR1H3 genetic variation on the expression of liver X receptor alfa and the progression of Alzheimer's Disease

Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease