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Markku Pasanen

Markku Pasanen

Visiting Researcher

School of Pharmacy, Faculty of Health Sciences

[email protected]

Information Publications

Research groups

Kuopio Birth Cohort (KuBiCo) 01.07.2012 -
Molecular Mechanisms Of Cardiometabolic Diseases

Publications

96/96 items

Comments to the Article Wu Y, Völler S, Goulooze SC, et al. A Novel Maturation Equation for Hepatic Clearance Across Preterm, Term Neonates, Children, and Adults: Application to Paracetamol and Its Metabolite. J Clin Pharmacol. 2025;65(12):1829-1843. doi: 10.1002/jcph.70080. PMID: 40910464; PMCID: PMC12649303
Pasanen, Markku; Juvonen, Risto O, 2026, Journal of clinical pharmacology, 66, 5, e70206. B1 Non-refereed journal articles
Avocado consumption during pregnancy linked to lower child food allergy risk: prospective KuBiCo study
Cheng, Feon W.; Bauer, Ella; Ford, Nikki A.; Backman, Katri; Voutilainen, Raimo; Pasanen, Markku; Keski-Nisula, Leea; Hantunen, Sari, 2025, Pediatric research, 99, 1, 1-7. A1 Journal article (refereed), original research
Evaluation of Lippia scaberrima Sond. and Aspalathus linearis (Burm.f.) R. Dahlgren extracts on human CYP enzymes and gold nanoparticle synthesis: implications for drug metabolism and cytotoxicity
Kok, Anna-Mari; Juvonen, Risto; Pasanen, Markku; Mandiwana, Vusani; Kalombo, Michel Lonji; Ray, Suprakas Sinha; Rikhotso-Mbungela, Rirhandzu; Lall, Namrita, 2024, BMC complementary medicine and therapies, 24, 1, 152. A1 Journal article (refereed), original research
ICH S1 prospective evaluation study: weight of evidence approach to predict outcome and value of 2-year rat carcinogenicity studies. A report from the regulatory authorities subgroup
Bourcier, Todd; McGovern, Timothy; Cavaliero, Tania; Ebere, Geoffrey; Nishikawa, Akiyoshi; Nishimura, Jihei; Ogawa, Kumiko; Pasanen, Markku; Vespa, Alisa; Van der Laan, Jan Willem, 2024, Frontiers in toxicology, 6, 1353783. A1 Journal article (refereed), original research
Maternal caffeine intake during pregnancy and the risk of delivering a small for gestational age baby: Kuopio Birth Cohort
Kukkonen, Anni; Hantunen, Sari; Voutilainen, Ari; Ruusunen, Anu; Backman, Katri; Kirjavainen, Pirkka V.; Ylilauri, Maija; Voutilainen, Raimo; Pasanen, Markku; Keski-Nisula, Leea, 2024, Archives of gynecology and obstetrics, 310, 1, 359-368. A1 Journal article (refereed), original research
Maternal caffeine, coffee and cola drink intake and the risk of gestational diabetes – Kuopio Birth Cohort
Kukkonen, Anni; Hantunen, Sari; Voutilainen, Ari; Ruusunen, Anu; Uusitalo, Lauri; Backman, Katri; Voutilainen, Raimo; Pasanen, Markku; Kirjavainen, Pirkka V; Keski-Nisula, Leea, 2024, Primary care diabetes, 18, 3, 362-367. A1 Journal article (refereed), original research
EMA commentary on the ICH guideline for testing for carcinogenicity of pharmaceuticals
van der Laan, Jan Willem; Andersson, Mikael; Beken, Sonja; Bonelli, Milton; Brendler‐Schwaab, Susanne; Kane, Rosemary; Pasanen, Markku; Ponzano, Stefano; Paur, Jakob; Siezen, Christine; Soleng, Anne; Whomsley, Rhys, 2023, British journal of clinical pharmacology, 89, 8, 2341-2348. B1 Non-refereed journal articles
Muisteloita Kuopion Faton tutkimuksesta ja opetuksesta ajalta miekka ja kypärä
Pasanen, Markku, 2023, Publications of the University of Eastern Finland : general series, 44, 69-73. E1 Popularised article, newspaper article
Aflatoxin B1 targeted gene expression profiles in human placental primary trophoblast cells
El-Dairi, Rami; Rysä, Jaana; Storvik, Markus; Pasanen, Markku; Huuskonen, Pasi, 2022, Current research in toxicology, 3, 100082. A1 Journal article (refereed), original research
Longitudinal Analyses of Diet Quality and Maternal Depressive Symptoms During Pregnancy: The Kuopio Birth Cohort Study
Airaksinen, Ville; Ruohomäki, Aleksi; Hantunen, Sari; Keski-Nisula, Leea; Luojus, Maria Katariina; Pekkanen, Juha; Tuomainen, Tomi-Pekka; Heinonen, Seppo; Pasanen, Markku; Lehto, Soili Marianne, 2022, Journal of the academy of nutrition and dietetics, 123, 1, 77-86.e4. A1 Journal article (refereed), original research
The impact of postpartum depressive symptoms on self-reported infant health and analgesic consumption at the age of 12 months: A prospective cohort study
Ruohomäki, Aleksi; Toffol, Elena; Airaksinen, Ville; Backman, Katri; Voutilainen, Raimo; Hantunen, Sari; Tuomainen, Tomi-Pekka; Lampi, Jussi; Kokki, Hannu; Luoma, Ilona; Kumpulainen, Kirsti; Heinonen, Seppo; Keski-Nisula, Leea; Pekkanen, Juha; Pasanen, Markku; Lehto, Soili M., 2021, Journal of psychiatric research, 136, 388-397. A1 Journal article (refereed), original research
Aryl hydrocarbon receptor (AhR) agonist ß-naphthoflavone regulated gene networks in human primary trophoblasts
El Dairi, Rami; Huuskonen, Pasi; Pasanen, Markku; Rysä, Jaana, 2020, Reproductive toxicology, 96, 370-379. A1 Journal article (refereed), original research
Caffeine content in newborn hair correlates with maternal dietary intake
Lehtonen, Anni; Uusitalo, Lauri; Auriola, Seppo; Backman, Katri; Heinonen, Seppo; Keski-Nisula, Leea; Pasanen, Markku; Pekkanen, Juha; Tuomainen, Tomi-Pekka; Voutilainen, Raimo; Hantunen, Sari; Lehtonen, Marko, 2020, European journal of nutrition, 2021; 60, 193-201. A1 Journal article (refereed), original research
Biomarkers of Toxicity in Human Placenta [Chapter 18]
Vähäkangas, Kirsi; Loikkanen, Jarkko; Sahlman, Heidi; Karttunen, Vesa; Repo, Jenni; Sieppi, Elina; Kummu, Maria; Huuskonen, Pasi; Myöhänen, Kirsi; Storvik, Markus; Pasanen, Markku; Myllynen, Päivi; Pelkonen, Olavi, 2019, Gupta, Ramesh C, Biomarkers in Toxicology (Second edition), 303-339. A3 Book section, Chapters in research books
In Vitro Human Metabolism and Inhibition Potency of Verbascoside for CYP Enzymes
Reid, AM; Juvonen, R; Huuskonen, P; Lehtonen, M; Pasanen, M; Lall, N, 2019, Molecules, 24, 11, 2191. A1 Journal article (refereed), original research
Laparoscopic Roux-en-Y gastric bypass surgery influenced pharmacokinetics of several drugs given as a cocktail with the highest impact observed for CYP1A2, CYP2C8 and CYP2E1 substrates
Puris, E; Pasanen, M; Ranta, VP; Gynther, M; Petsalo, A; Käkelä, P; Männistö, V; Pihlajamäki, J, 2019, Basic and clinical pharmacology and toxicology, 125, 2, 123-132. A1 Journal article (refereed), original research
The dynamic course of peripartum depression across pregnancy and childbirth
Dekel, S; Ein-Dor, T; Ruohomäki, A; Lampi, J; Voutilainen, S; Tuomainen, TP; Heinonen, S; Kumpulainen, K; Pekkanen, J; Keski-Nisula, L; Pasanen, M; Lehto, SM, 2019, Journal of psychiatric research, 113, 72-78. A1 Journal article (refereed), original research
Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives
Niinivehmas, S; Postila, PA; Rauhamäki, S; Manivannan, E; Kortet, S; Ahinko, M; Huuskonen, P; Nyberg, N; Koskimies, P; Lätti, S; Multamäki, E; Juvonen, RO; Raunio, H; Pasanen, M; Huuskonen, J; Pentikäinen, OT, 2018, Journal of enzyme inhibition and medicinal chemistry, 33, 1, 743-754. A1 Journal article (refereed), original research
Environmental Intolerance, Symptoms and Disability Among Fertile-Aged Women
Vuokko, Aki; Karvala, Kirsi; Lampi, Jussi; Keski-Nisula, Leea; Pasanen, Markku; Voutilainen, Raimo; Pekkanen, Juha; Sainio, Markku, 2018, International journal of environmental research and public health, 15, 2, 293. A1 Journal article (refereed), original research
Kuopio birth cohort - design of a Finnish joint research effort for identification of environmental and lifestyle risk factors for the wellbeing of the mother and the newborn child
Huuskonen, P; Keski-Nisula, L; Heinonen, S; Voutilainen, S; Tuomainen, TP; Pekkanen, J; Lampi, J; Lehto, SM; Haaparanta, H; Elomaa, AP; Voutilainen, R; Backman, K; Kokki, H; Kumpulainen, K; Paananen, J; Vähäkangas, K; Pasanen, M, 2018, Bmc pregnancy and childbirth, 18, 381. A1 Journal article (refereed), original research
New glutathione conjugate of the pyrrolizidine alkaloids produced by human cytosolic enzyme dependent reactions in vitro
Muluneh, Fashe; Häkkinen, Merja R; El Dairi, Rami; Pasanen, Markku; Juvonen, Risto O, 2018, Rapid communications in mass spectrometry, 32, 16, 1344-1352. A1 Journal article (refereed), original research
Peroxisome proliferator activated receptor gamma (PPAR-gamma) ligand pioglitazone regulated gene networks in term human primary trophoblast cells
Dairi, Rami El; Huuskonen, Pasi; Pasanen, Markku; Rysä, Jaana, 2018, Reproductive toxicology, 81, 99-107. A1 Journal article (refereed), original research
Structure-Activity Relationship Analysis of 3-Phenylcoumarin-Based Monoamine Oxidase B Inhibitors
Rauhamaki, Sanna; Postila, Pekka A; Niinivehmas, Sanna; Kortet, Sami; Schildt, Emmi; Pasanen, Mira; Manivannan, Elangovan; Ahinko, Mira; Koskimies, Pasi; Nyberg, Niina; Huuskonen, Pasi; Multamaki, Elina; Pasanen, Markku; Juvonen, Risto O; Raunio, Hannu; Huuskonen, Juhani; Pentikainen, Olli T, 2018, Frontiers in chemistry, 6, 41. A1 Journal article (refereed), original research
Tatuointivärien turvallisuuden valvonta
Paulamäki, Jasmin; Pasanen, Markku; Rysä, Jaana, 2018, Dosis, 34, 2, 50-59. A2 Review article, Literature review, Systematic review
The association between gestational diabetes mellitus and postpartum depressive symptomatology: A prospective cohort study
Ruohomäki, Aleksi; Toffol, Elena; Upadhyaya, Subina; Keski-Nisula, Leea; Pekkanen, Juha; Lampi, Jussi; Voutilainen, Sari; Tuomainen, Tomi-Pekka; Heinonen, Seppo; Kumpulainen, Kirsti; Pasanen, Markku; Lehto, Soili M, 2018, Journal of affective disorders, 241, 263-268. A1 Journal article (refereed), original research
Metabolomics Applications in Herbal Medicine
Hanhineva Kati, Pasanen Markku, 2017, Pelkonen O, Duez P, Vuorela P, Vuorela H, Toxicology of Herbal Products, 165-178. A3 Book section, Chapters in research books
Molecular targets of chloropicrin in human airway epithelial cells
Pesonen M, Rysä J, Storvik M, Rilla K, Pasanen M, Vähäkangas K, 2017, Toxicology in vitro, 42, 247-254. A1 Journal article (refereed), original research
Oligonucleotide-based pharmaceuticals: Non-clinical and clinical safety signals and non-clinical testing strategies
Mustonen Enni-Kaisa, Palomäki Tiina, Pasanen Markku, 2017, Regulatory toxicology and pharmacology, 90, 328-341. A1 Journal article (refereed), original research
A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probe drugs and their corresponding metabolites in human serum and urine
Puris Elena, Pasanen Markku, Gynther Mikko, Häkkinen Merja R, Pihlajamäki Jussi, Keränen Tapani, Honkakoski Paavo, Raunio Hannu, Petsalo Aleksanteri, 2016, Analytical and bioanalytical chemistry, 2017; 409, 1, 251-268. A1 Journal article (refereed), original research
Author's Reply to Parsons: "Cytotoxicity of Oxycodone and Morphine in Human Neuroblastoma and Mouse Motoneuronal Cells: A Comparative Approach"
Kokki Merja, Pasanen Markku, Kokki Hannu, 2016, Drugs in R and D, 16, 3, 287-288. B1 Non-refereed journal articles
Candidate Molecule Selection Based on In Silico Predicted ADMET Properties of 12 Indenoindole Derivatives
Guragossian Nathalie, Gozzi Gustavo J, Fouillet Bruno, Gustin Marie-Paule, Terreux Raphaël, Bouaziz Zouhair, Marminon Christelle, Jose Joachim, Di Pietro Attilio, Pasanen Markku, Le Borgne Marc, 2016, Chemical informatics, 2, 2, 1-9. A1 Journal article (refereed), original research
Critical analysis of carcinogenicity study outcomes. Relationship with pharmacological properties
van der Laan Jan W, Kasper Peter, Silva Lima Beatriz, Jones David R, Pasanen Markku, 2016, Critical reviews in toxicology, 46, 7, 587-614. A2 Review article, Literature review, Systematic review
Cytotoxicity of Oxycodone and Morphine in Human Neuroblastoma and Mouse Motoneuronal Cells: A Comparative Approach
Kokki Merja, Pesonen Maija, Vehviläinen Piia, Litmala Outi, Pasanen Markku, Kokki Hannu, 2016, Drugs in R and D, 16, 2, 155-163. A1 Journal article (refereed), original research
SAB joint keynote: The eTOX project from regulatory perspective
Kavlock Robert J, Pasanen Markku, Kasper Peter, 2016, eTOX Newsletter, 18, 1-2. D1 Article in a trade journal
The human placental proteome is affected by maternal smoking
Huuskonen Pasi, Amezaga Maria R, Bellingham Michelle, Jones Lucy H, Storvik Markus, Häkkinen Merja, Keski-Nisula Leea, Heinonen Seppo, O'Shaughnessy Peter J, Fowler Paul A, Pasanen Markku, 2016, Reproductive toxicology, 63, 22-31. A1 Journal article (refereed), original research
Triethylenetetramine Modulates Polyamine and Energy Metabolism and Inhibits Cancer Cell Proliferation
Hyvönen Mervi T, Ucal Sebahat, Pasanen Markku, Peräniemi Sirpa, Weisell Janne, Khomutov Maxim, Khomutov Alex R, Vepsäläinen Jouko, Alhonen Leena, Keinänen Tuomo A, 2016, Biochemical journal, 473, 10, 1433-1441. A1 Journal article (refereed), original research
Analysis of nitromethane from samples exposed in vitro to chloropicrin by stable isotope dilution headspace gas chromatography with mass spectrometry
Halme Mia, Pesonen Maija, Grandell Toni, Kuula Matti, Pasanen Markku, Vähäkangas Kirsi, Vanninen Paula, 2015, Journal of separation science, 38, 3383-3389. A1 Journal article (refereed), original research
Applying human and pig hepatic in vitro experiments for sulfur mustard study: Screening and identification of metabolites by liquid chromatography/tandem mass spectrometry
Halme Mia, Pesonen Maija, Hakala Ullastiina, Pasanen Markku, Vähäkangas Kirsi, Vanninen Paula, 2015, Rapid communications in mass spectrometry, 29, 14, 1279-1287. A1 Journal article (refereed), original research
Comparison of in vitro metabolism and cytotoxicity of capsaicin and dihydrocapsaicin
Halme Mia, Pesonen Maija, Salo Heta, Söderström Martin, Pasanen Markku, Vähäkangas Kirsi, Vanninen Paula, 2015, Journal of chromatography b: analytical technologies in the biomedical and life sciences, 2016; 1009-1010, 17-24. A1 Journal article (refereed), original research
Comparison of trapping profiles between d-peptides and glutathione in the identification of reactive metabolites
Laine Jaana E, Häkkinen Merja R, Auriola Seppo, Juvonen Risto O, Pasanen Markku, 2015, Toxicology reports, 2, 1024-1032. A1 Journal article (refereed), original research
In Silico Prediction of the Site of Oxidation by Cytochrome P450 3A4 That Leads to the Formation of the Toxic Metabolites of Pyrrolizidine Alkaloids
Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Vepsäläinen Jouko, Pasanen Markku, Rahnasto-Rilla Minna, 2015, Chemical research in toxicology, 28, 4, 702-710. A1 Journal article (refereed), original research
Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes
Juvonen Risto O, Kuusisto Mira, Fohrgrup Carolin, Pitkänen Mari H, Nevalainen Tapio J, Auriola Seppo, Raunio Hannu, Pasanen Markku, Pentikäinen Olli T, 2015, Xenobiotica, 2016; 46, 1, 14-24. A1 Journal article (refereed), original research
Species-specific differences in the in vitro metabolism of lasiocarpine
Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Räsänen Juha, Pasanen Markku, 2015, Chemical research in toxicology, 28, 10, 2034-2044. A1 Journal article (refereed), original research
Transcriptomic Analysis of Human Primary Bronchial Epithelial Cells after Chloropicrin Treatment
Pesonen Maija, Storvik Markus, Kokkola Tarja, Rysä Jaana, Vähäkangas Kirsi, Pasanen Markku, 2015, Chemical research in toxicology, 28, 10, 1926-1935. A1 Journal article (refereed), original research
Zearalenone metabolism in human placental subcellular organelles, JEG-3 cells, and recombinant CYP19A1
Huuskonen Pasi, Auriola Seppo, Pasanen Markku, 2015, Placenta, 36, 9, 1052-1055. A1 Journal article (refereed), original research
Alkueläimiin vaikuttavat lääkeaineet: Alkueläimiin ja loisiin vaikuttavat lääkeaineet sekä desinfioivat aineet [Luku 36]
Pelkonen Olavi, Pasanen Markku, 2014, Pelkonen Olavi, Ruskoaho Heikki, Hakkola Jukka, Huupponen Risto, MacDonald Ewen, Moilanen Eeva, Pasanen Markku, Scheinin Mika, Vähäkangas Kirsi, Lääketieteellinen farmakologia ja toksikologia, 966-968. A3 Book section, Chapters in research books
Biomarkers of toxicity in human placenta [Chapter 20]
Vähäkangas Kirsi, Loikkanen Jarkko, Sahlman Heidi, Karttunen Vesa, Repo Jenni, Sieppi Elina, Kummu Maria, Huuskonen Pasi, Myöhänen Kirsi, Storvik Markus, Pasanen Markku, Myllynen Päivi, Pelkonen Olavi, 2014, Gupta Ramesh C, Biomarkers in Toxicology, 325-360. A3 Book section, Chapters in research books
Chloropicrin-induced toxic responses in human lung epithelial cells
Pesonen Maija, Häkkinen Merja, Rilla Kirsi, Juvonen Risto, Kuitunen Tapio, Pasanen Markku, Vähäkangas Kirsi, 2014, Toxicology letters, 226, 236-244. A1 Journal article (refereed), original research
Identification of a New Reactive Metabolite of Pyrrolizidine Alkaloid Retrorsine: (3H-Pyrrolizin-7-yl)methanol
Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Rahnasto-Rilla Minna, Auriola Seppo, Soininen Pasi, Vepsäläinen Jouko, Pasanen Markku, 2014, Chemical research in toxicology, 27, 1950-1957. A1 Journal article (refereed), original research
Liver safety assessment: required data elements and best practices for data collection and standardization in clinical trials
Avigan Mark I, Bjornsson Einar S, Pasanen Markku, Cooper Charles, Andrade Raul J, Watkins Paul B, Lewis James H, Merz Michael, 2014, Drug safety, 37, Suppl 1, 19-31. A2 Review article, Literature review, Systematic review
Lääkeainemyrkytykset [Luku 41]
Vähäkangas Kirsi, Myllynen Päivi, Raunio Hannu, Pasanen Markku, 2014, Pelkonen Olavi, Ruskoaho Heikki, Hakkola Jukka, Huupponen Risto, MacDonald Ewen, Moilanen Eeva, Pasanen Markku, Scheinin Mika, Vähäkangas Kirsi, Lääketieteellinen farmakologia ja toksikologia, 1016-1026. A3 Book section, Chapters in research books
Lääketieteellinen farmakologia ja toksikologia
Pelkonen Olavi, Ruskoaho Heikki, Hakkola Jukka, Huupponen Risto, MacDonald Ewen, Moilanen Eeva, Pasanen Markku, Scheinin Mika, Vähäkangas Kirsi, 2014, Kustannus Oy Duodecim. C2 Edited book, conference proceedings or special issue of a journal
Nukleiinihappoaineenvaihduntaan vaikuttavat aineet: Bakteerilääkkeet [Luku 33]
Huupponen Risto, Pasanen Markku, 2014, Pelkonen Olavi, Ruskoaho Heikki, Hakkola Jukka, Huupponen Risto, MacDonald Ewen, Moilanen Eeva, Pasanen Markku, Scheinin Mika, Vähäkangas Kirsi, Lääketieteellinen farmakologia ja toksikologia, 940-941. A3 Book section, Chapters in research books
Raskauden aikaisen lääketutkimuksen haasteita
Kokki Merja, Pasanen Markku, Heikkinen Aki T, Kokki Hannu, 2014, Finnanest, 47, 2, 142-147. D1 Article in a trade journal
Reactive Metabolites in Early Drug Development: Predictive in Vitro Tools
Pelkonen Olavi, Pasanen Markku, Tolonen Ari, Koskinen Mikko, Hakkola Jukka, Abass Khaled, Laine Jaana, Häkkinen Merja, Juvonen Risto, Auriola Seppo, Storvik Markus, Huuskonen Pasi, Rousu Timo, Rahikkala Maiju, 2014, Current medicinal chemistry, 2015; 22, 538-550. A2 Review article, Literature review, Systematic review
Recommendations from a global cross-company data sharing initiative on the incorporation of recovery phase animals in safety assessment studies to support first-in-human clinical trials
Sewell Fiona, Chapman Kathryn, Baldrick Paul, Brewster David, Broadmeadow Alan, Brown Paul, Burns-Naas Leigh Ann, Clarke Janet, Constan Alex, Couch Jessica, Czupalla Oliver, Danks Andy, DeGeorge Joseph, de Haan Lolke, Hettinger Klaudia, Hill Marilyn, Festag Matthias, Jacobs Abby, Jacobson-Kram David, Kopytek Stephan et al, 2014, Regulatory toxicology and pharmacology, 70, 413-429. A1 Journal article (refereed), original research
Sienilääkkeet [Luku 35]
Pelkonen Olavi, Pasanen Markku, 2014, Pelkonen Olavi, Ruskoaho Heikki, Hakkola Jukka, Huupponen Risto, MacDonald Ewen, Moilanen Eeva, Pasanen Markku, Scheinin Mika, Vähäkangas Kirsi, Lääketieteellinen farmakologia ja toksikologia, 962-964. A3 Book section, Chapters in research books
The unique characteristics of the placental transcriptome and the hormonal metabolism enzymes in placenta
Storvik Markus, Huuskonen Pasi, Pehkonen Petri, Pasanen Markku, 2014, Reproductive toxicology, 47, 9-14. A1 Journal article (refereed), original research
Vierasaineiden metabolia
Raunio Hannu, Pasanen Markku, Juvonen Risto, Rahnasto-Rilla Minna, Tani Niina, Hukkanen Kaisa, Huuskonen Pasi, Muluneh Fashe, 2014, Dosis, 30, 3, 208. B1 Non-refereed journal articles
A high throughput assay for the glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin by recombinant human UDP-glucuronosyltransferases and liver microsomes
Rahikainen Tuomas, Häkkinen Merja R, Finel Moshe, Pasanen Markku, Juvonen Risto O, 2013, Xenobiotica, 43, 10, 853-861. A1 Journal article (refereed), original research
Ilokaasun päihdekäytön vaarat [Pääkirjoitus]
Tacke Ulrich, Pasanen Markku, 2013, Duodecim, 129, 1517-1519. B1 Non-refereed journal articles
The effects of aflatoxin B1 on transporters and steroid metabolizing enzymes in JEG-3 cells
Huuskonen Pasi, Myllynen Päivi, Storvik Markus, Pasanen Markku, 2013, Toxicology letters, 218, 200-206. A1 Journal article (refereed), original research
Yleisen toksikologian kansainvälisen maisteriohjelman kehittyminen - tieteellinen tutkimus opetuksen perustana
Vähäkangas Kirsi, Pasanen Markku, Raunio Hannu, Mensalo Päivi, Juvonen Risto, Loikkanen Jarkko, 2013, Ahonen R, Laitinen K, Lapinjoki S, Mensalo P, Ranta V-P, Ylikangas H (toim)., Muutosten vuosikymmen : Itä-Suomen yliopiston farmasian laitos 40 vuotta, 48-53. D2 Article in a professional book (incl. an introduction by the editor)
Aflatoxin B1 up-regulates CYP19A1 in JEG-3 cells
Huuskonen Pasi, Storvik Markus, Kyllönen Taija, Lehtonen Sarka, El-Nezami Hani, Auriola Seppo, Pasanen Markku, 2012, -.
Chloropicrin induces endoplasmic reticulum stress in human retinal pigment epithelial cells
Pesonen Maija, Pasanen Markku, Loikkanen Jarkko, Naukkarinen A, Hemmilä M, Seulanto H, Kuitunen K, Vähäkangas Kirsi, 2012, Toxicology letters, 211, 239-245. A1 Journal article (refereed), original research
Lääkeainemetabolian merkitys lääkekehittelyssä - lajierot ja ennustamisen vaikeus [with English Summary]
Pelkonen Olavi, Turpeinen Miia, Pasanen Markku, 2012, Dosis, 28, 1, 46-51. A2 Review article, Literature review, Systematic review
Omics and its potential impact on R&D and regulation of complex herbal products
Pelkonen Olavi, Pasanen Markku, Lindon John C, Chan Kelvin, Zhao Liping, Deal Greer, Xu Qihe, Fan Tai-Ping, 2012, Journal of ethnopharmacology, 140, 587-593. A2 Review article, Literature review, Systematic review
Preservation, induction or incorporation of metabolism into the in vitro cellular system - Views to current opportunities and limitations
Pelkonen Olavi, Turpeinen Miia, Hakkola Jukka, Abass Khaled, Pasanen Markku, Raunio Hannu, Vähäkangas Kirsi, 2012, Toxicology in vitro, 2013:27, 1578-1583. A2 Review article, Literature review, Systematic review
Voiko liian tulinen ruoka tappaa? [885 kysymystä ja vastausta. tiede.fi/kysy_asiantuntijalta]
Pasanen Markku, 2012, Tiede, 10, 61. E1 Popularised article, newspaper article
2'-Deoxyguanosine as a surrogate trapping agent for DNA reactive drug metabolites
Häkkinen Merja R, Laine Jaana E, Juvonen Risto O, Auriola Seppo, Häyrinen Jukka, Pasanen Markku, 2011, Toxicology letters, 207, 34-41. A1 Journal article (refereed), original research
Aflatoxin B1 - a potential endocrine disruptor - up-regulates CYP19A1 in JEG-3 cells
Storvik Markus, Huuskonen Pasi, Kyllönen Taija, Lehtonen Sarka, El-Nezami Hani, Auriola Seppo, Pasanen Markku, 2011, Toxicology letters, 202, 3, 161 - 167. A1 Journal article (refereed), original research
Biomarkkerit inkapasitoivien ja ärsyttävien yhdisteiden tunnisteina
Pesonen Maija, Kuitunen Tapio, Halme Mia, Vanninen Paula, Seulanto Heikki, Hemmilä Matti, Pasanen Markku, Vähäkangas Kirsi, 2011, Sotilaslääketieteen aikakauslehti, 86, 2, 9-12. A2 Review article, Literature review, Systematic review
Pippurisumutteiden kapsaisiinit ja toksiset vasteet
Pasanen Markku, Pesonen Maija, Vähäkangas Kirsi, Halme Mia, Vanninen Paula, Seulanto Heikki, Hemmilä Matti, Kuitunen Tapio, 2011, Sotilaslääketieteen aikakauslehti, 86, 3, 11-14. A2 Review article, Literature review, Systematic review
Simple, direct, and informative method for the assessment of CYP2C19 enzyme inactivation kinetics
Salminen Kaisa A, Leppänen Jukka, Venäläinen Jarkko I, Pasanen Markku, Auriola Seppo, Juvonen Risto O, Raunio Hannu, 2011, Drug metabolism and disposition, 39, 3, 412 - 418. A1 Journal article (refereed), original research
d-Isomer of gly-tyr-pro-cys-pro-his-pro peptide: A novel and sensitive in vitro trapping agent to detect reactive metabolites by electrospray mass spectrometry
Laine Jaana, Auriola Seppo, Pasanen Markku, Juvonen Risto, 2011, Toxicology in vitro, 25, 411 - 425. A1 Journal article (refereed), original research
Human placental glutathione S-transferase activity and polycyclic aromatic hydrocarbon DNA adducts as biomarkers for environmental oxidative stress in placentas from pregnant women living in radioactivity- and chemically-polluted regions
Obolenskaya MY, Teplyuk NM, Divi RL, Poirier MC, Filimonova NB, Zadrozna M & Pasanen MJ, 2010, Toxicology letters, 196, 80 - 86. A1 Journal article (refereed), original research
Parasetamoli - järki ja tunteet
Pasanen M & Kokki H, 2010, Finnanest, 43, 2, 126-128. D1 Article in a trade journal
Renal biomarker qualification submission: a dialog between the FDA - EMEA and Predictive Safety Testing Consortium
Dieterle F, Sistare F, Goodsaid F, Papaluca M, Ozer JS, Webb CP, Baer W, Senagore A, Schipper MJ, Vonderscher J et al, 2010, Nature biotechnology, 28, 5, 455 - 462. A2 Review article, Literature review, Systematic review
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
Laine JE, Auriola S, Pasanen M, Juvonen RO, 2009, Xenobiotica, 39, 1, 11-21. A1 Journal article (refereed), original research
Demonstration of ethanol-induced protein adducts in oral leukoplakia (pre-cancer) and cancer
Warnakulasuriya S, Parkkila S, NagaoT, Preedy VR, Pasanen M, Koivisto H, Niemelä O, 2008, Journal of oral pathology and medicine, 37, 3, 157-65. A1 Journal article (refereed), original research
Microarray analysis of the global alterations in the gene expression in the placentas from cigarette-smoking mothers
Huuskonen P, Storvik M, Reinisalo M, Honkakoski P, Rysä J, Hakkola J, Pasanen M, 2008, Clinical pharmacology and therapeutics, 83, 542-550. A1 Journal article (refereed), original research
Polycyclic aromatic hydrocarbon (PAH) metabolizing enzyme activities in human lung, and their inducibility by exposure to naphthalene, phenanthrene, pyrene, chrysene, and benzo(a)pyrene as shown in the rat lung and liver
Elovaara E, Mikkola J, Stockmann-Juvala H, Luukkanen L, Keski-Hynnilä H, Kostiainen R, Pasanen M, Pelkonen O, Vainio H, 2007, Archives of toxicology, 81, 169-182. A1 Journal article (refereed), original research
Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: A comparative study in vitro
Turpeinen M, Ghiciuc C, Opritoui M, Tursas L, Pelkonen O, Pasanen M, 2007, Xenobiotica, 37, 12, 1367-1377. A1 Journal article (refereed), original research
The fate and effects of xenobiotics in human placenta
Myllynen P, Pasanen M, Vähäkangas K, 2007, Expert opinion on drug metabolism and toxicology, 3, 3, 331-346. A2 Review article, Literature review, Systematic review
Geeniterapia
Pasanen M, 2006, TABU, 2, 24. D1 Article in a trade journal
Cocaine increases circulating levels of atrial natriuretic peptide and pro atrial natriuretic peptide N-terminal fragment in conscious rats
Pelkonen M, Luodonpää M, Vuolteenaho O, Pasanen M, Ruskoaho H, 1996, European journal of pharmacology, 304, 55-62. A1 Journal article (refereed), original research
Determination of urinary 2-mercaptobenzothiazole (2-MBT), the main metabolite of 2-(thiocyanomethylthio)benzothiazole (TCMTB) in humans and rats
Manninen A, Auriola S, Vartiainen M, Liesivuori J, Turunen T, Pasanen M, 1996, Archives of toxicology, 70, 579-584. A1 Journal article (refereed), original research
Expression of Xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta
Hakkola J, Pasanen M, Hukkanen J, Pelkonen O, Mäenpää J, Edwards RJ, Boobis AR, Raunio H, 1996, Biochemical pharmacology, 51, 403-411. A1 Journal article (refereed), original research
Regenerative changes in hepatic morphology and enhanced expression of CYP2B10 and CYP3A during daily administration of cocaine
Pellinen P, Stenbäck F, Kojo A, Honkakoski P, Gelboin HV, Pasanen M, 1996, Hepatology, 23, 3, 515-523. A1 Journal article (refereed), original research
Competitive inhibition of coumarin 7-hydroxylation by pilocarpine and its interaction with mouse CYP 2A5 and human CYP 2A6
Kinonen T, Pasanen M, Gynther J, Poso A, Järvinen T, Alhava E, Juvonen RO, 1995, British journal of pharmacology, 116, 2625-2630. A1 Journal article (refereed), original research
Expression of extrahepatic cytochrome P450 in humans
Raunio H, Pasanen M, Mäenpää J, Hakkola J, Pelkonen O, 1995, Pacifici GM, Fracchia GN, Advances in Drug Metabolism in Man, 235-287. A3 Book section, Chapters in research books
The role of CYP enzymes in cocaine-induced liver damage
Pasanen M, Pellinen P, Stenbäck F, Juvonen RO, Raunio H, Pelkonen O, 1995, Archives of toxicology, 69, 287-290. A2 Review article, Literature review, Systematic review
Travel broadens the mind not the waistline
Pasanen M, 1995, Arvela P, Pienimäki P, Ruskoaho H, Vähäkangas K, Rautio A, Raunio H, Drug Metabolism and Cytochromes P450. Olavi Pelkonen 50 years, 69-71. A3 Book section, Chapters in research books
Cytochrome P4502A5 expression and inducibility by phenobarbital is modulated by cAMP in mouse primary hepatocytes
Salonpää P, Pelkonen O, Kojo A, Pasanen M, Negishi M, Raunio H, 1994, Biochemical and biophysical research communications, 205, 1, 631-637. A1 Journal article (refereed), original research
Modification of hepatic cytochrome P450 profile by cocaine-induced hepatotoxicity in DBA/2 mouse
Pellinen P, Stenbäck F, Raunio H, Pelkonen O, Pasanen M, 1994, European journal of pharmacology, 292, 57-65. A1 Journal article (refereed), original research
The expression and environmental regulation of P450 enzymes in human placenta
Pasanen M, Pelkonen O, 1994, Critical reviews in toxicology, 24, 3, 211-229. A1 Journal article (refereed), original research

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Markku Pasanen

Research groups

Avocado consumption during pregnancy linked to lower child food allergy risk: prospective KuBiCo study

Evaluation of Lippia scaberrima Sond. and Aspalathus linearis (Burm.f.) R. Dahlgren extracts on human CYP enzymes and gold nanoparticle synthesis: implications for drug metabolism and cytotoxicity

ICH S1 prospective evaluation study: weight of evidence approach to predict outcome and value of 2-year rat carcinogenicity studies. A report from the regulatory authorities subgroup

Maternal caffeine intake during pregnancy and the risk of delivering a small for gestational age baby: Kuopio Birth Cohort

Maternal caffeine, coffee and cola drink intake and the risk of gestational diabetes – Kuopio Birth Cohort

EMA commentary on the ICH guideline for testing for carcinogenicity of pharmaceuticals

Muisteloita Kuopion Faton tutkimuksesta ja opetuksesta ajalta miekka ja kypärä

Aflatoxin B1 targeted gene expression profiles in human placental primary trophoblast cells

Longitudinal Analyses of Diet Quality and Maternal Depressive Symptoms During Pregnancy: The Kuopio Birth Cohort Study

The impact of postpartum depressive symptoms on self-reported infant health and analgesic consumption at the age of 12 months: A prospective cohort study

Aryl hydrocarbon receptor (AhR) agonist ß-naphthoflavone regulated gene networks in human primary trophoblasts

Caffeine content in newborn hair correlates with maternal dietary intake

Biomarkers of Toxicity in Human Placenta [Chapter 18]

In Vitro Human Metabolism and Inhibition Potency of Verbascoside for CYP Enzymes

Laparoscopic Roux-en-Y gastric bypass surgery influenced pharmacokinetics of several drugs given as a cocktail with the highest impact observed for CYP1A2, CYP2C8 and CYP2E1 substrates

The dynamic course of peripartum depression across pregnancy and childbirth

Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives

Environmental Intolerance, Symptoms and Disability Among Fertile-Aged Women

Kuopio birth cohort - design of a Finnish joint research effort for identification of environmental and lifestyle risk factors for the wellbeing of the mother and the newborn child

New glutathione conjugate of the pyrrolizidine alkaloids produced by human cytosolic enzyme dependent reactions in vitro

Peroxisome proliferator activated receptor gamma (PPAR-gamma) ligand pioglitazone regulated gene networks in term human primary trophoblast cells

Structure-Activity Relationship Analysis of 3-Phenylcoumarin-Based Monoamine Oxidase B Inhibitors

Tatuointivärien turvallisuuden valvonta

The association between gestational diabetes mellitus and postpartum depressive symptomatology: A prospective cohort study

Metabolomics Applications in Herbal Medicine

Molecular targets of chloropicrin in human airway epithelial cells

Oligonucleotide-based pharmaceuticals: Non-clinical and clinical safety signals and non-clinical testing strategies

A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probe drugs and their corresponding metabolites in human serum and urine

Author's Reply to Parsons: "Cytotoxicity of Oxycodone and Morphine in Human Neuroblastoma and Mouse Motoneuronal Cells: A Comparative Approach"

Candidate Molecule Selection Based on In Silico Predicted ADMET Properties of 12 Indenoindole Derivatives

Critical analysis of carcinogenicity study outcomes. Relationship with pharmacological properties

Cytotoxicity of Oxycodone and Morphine in Human Neuroblastoma and Mouse Motoneuronal Cells: A Comparative Approach

SAB joint keynote: The eTOX project from regulatory perspective

The human placental proteome is affected by maternal smoking

Triethylenetetramine Modulates Polyamine and Energy Metabolism and Inhibits Cancer Cell Proliferation

Analysis of nitromethane from samples exposed in vitro to chloropicrin by stable isotope dilution headspace gas chromatography with mass spectrometry

Applying human and pig hepatic in vitro experiments for sulfur mustard study: Screening and identification of metabolites by liquid chromatography/tandem mass spectrometry

Comparison of in vitro metabolism and cytotoxicity of capsaicin and dihydrocapsaicin

Comparison of trapping profiles between d-peptides and glutathione in the identification of reactive metabolites

In Silico Prediction of the Site of Oxidation by Cytochrome P450 3A4 That Leads to the Formation of the Toxic Metabolites of Pyrrolizidine Alkaloids

Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes

Species-specific differences in the in vitro metabolism of lasiocarpine

Transcriptomic Analysis of Human Primary Bronchial Epithelial Cells after Chloropicrin Treatment

Zearalenone metabolism in human placental subcellular organelles, JEG-3 cells, and recombinant CYP19A1

Alkueläimiin vaikuttavat lääkeaineet: Alkueläimiin ja loisiin vaikuttavat lääkeaineet sekä desinfioivat aineet [Luku 36]

Biomarkers of toxicity in human placenta [Chapter 20]

Chloropicrin-induced toxic responses in human lung epithelial cells

Identification of a New Reactive Metabolite of Pyrrolizidine Alkaloid Retrorsine: (3H-Pyrrolizin-7-yl)methanol

Liver safety assessment: required data elements and best practices for data collection and standardization in clinical trials

Lääkeainemyrkytykset [Luku 41]

Lääketieteellinen farmakologia ja toksikologia

Nukleiinihappoaineenvaihduntaan vaikuttavat aineet: Bakteerilääkkeet [Luku 33]

Raskauden aikaisen lääketutkimuksen haasteita

Reactive Metabolites in Early Drug Development: Predictive in Vitro Tools

Recommendations from a global cross-company data sharing initiative on the incorporation of recovery phase animals in safety assessment studies to support first-in-human clinical trials

Sienilääkkeet [Luku 35]

The unique characteristics of the placental transcriptome and the hormonal metabolism enzymes in placenta

Vierasaineiden metabolia

A high throughput assay for the glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin by recombinant human UDP-glucuronosyltransferases and liver microsomes

Ilokaasun päihdekäytön vaarat [Pääkirjoitus]

The effects of aflatoxin B1 on transporters and steroid metabolizing enzymes in JEG-3 cells

Yleisen toksikologian kansainvälisen maisteriohjelman kehittyminen - tieteellinen tutkimus opetuksen perustana

Aflatoxin B1 up-regulates CYP19A1 in JEG-3 cells

Chloropicrin induces endoplasmic reticulum stress in human retinal pigment epithelial cells

Lääkeainemetabolian merkitys lääkekehittelyssä - lajierot ja ennustamisen vaikeus [with English Summary]

Omics and its potential impact on R&D and regulation of complex herbal products

Preservation, induction or incorporation of metabolism into the in vitro cellular system - Views to current opportunities and limitations

Voiko liian tulinen ruoka tappaa? [885 kysymystä ja vastausta. tiede.fi/kysy_asiantuntijalta]

2'-Deoxyguanosine as a surrogate trapping agent for DNA reactive drug metabolites

Aflatoxin B1 - a potential endocrine disruptor - up-regulates CYP19A1 in JEG-3 cells

Biomarkkerit inkapasitoivien ja ärsyttävien yhdisteiden tunnisteina

Pippurisumutteiden kapsaisiinit ja toksiset vasteet

Simple, direct, and informative method for the assessment of CYP2C19 enzyme inactivation kinetics

d-Isomer of gly-tyr-pro-cys-pro-his-pro peptide: A novel and sensitive in vitro trapping agent to detect reactive metabolites by electrospray mass spectrometry

Human placental glutathione S-transferase activity and polycyclic aromatic hydrocarbon DNA adducts as biomarkers for environmental oxidative stress in placentas from pregnant women living in radioactivity- and chemically-polluted regions

Parasetamoli - järki ja tunteet

Renal biomarker qualification submission: a dialog between the FDA - EMEA and Predictive Safety Testing Consortium