Genetics of gene regulation in disease

Transcription factors regulate their target genes not only upon specific stimuli, but also through binding to specific DNA sequences. Genetic variation that occurs on those binding sequences may disturb target gene expression. It is also a potential source for the “missing variation” in polygenic...

Molecular Pathology and Genetics of Cancer

We study the etiology and pathogenesis of malignant diseases with a special emphasis on the histopathologic, molecular pathologic and genetic/genomic factors. Profound collaboration between several research groups at the UEF and Kuopio University Hospital (KUH) as well as with our national and in...

Nihay Laham Karam

Assistant Professor , A.I. Virtanen Institute for Molecular Sciences

Tiia Turunen

Grant-funded Researcher , A.I. Virtanen Institute for Molecular Sciences

Vascular Biology (Laakkonen)

'From basic science to translational impact.'
The goal of our junior research group is to improve therapeutics and diagnostics of cardiovascular diseases by understanding the biology behind the diseases. The main focus is in studying vascular anomalies and aortic aneurysms. Particularly ...

Epigenomics of vitamin D

01.10.2000 -
The scientific interest of our team is on mechanisms of gene regulation and its impact on major common diseases, such as type 2 diabetes, atherosclerosis and cancer. Our investigations use methods of molecular biology, bioinformatics and systems biology.