Atte Seppo Aleksi Eskelinen
Postdoctoral Researcher
Postdoctoral researcher
Department of Technical Physics, Faculty of Science, Forestry and Technology
I am currently a postdoctoral researcher in the fields of biomechanics, mechanobiology, computational modeling, musculoskeletal diseases, and osteoarthritis. My current research interests include experimental and computational modeling of cartilage degradation, and biomechanical and inflammatory mechanisms in osteoarthritis and joint pain. The aim of the current research project is to develop personalized predictive models of osteoarthritis progression and pain to optimize treatment strategies for pain-free, improved musculoskeletal healthcare.
Research groups
Publications
12/12 items-
Loss of collagen content is localized near cartilage lesions on the day of injurious loading and intensified on day 12
Hamada, Moustafa; Eskelinen, Atte SA; Florea, Cristina; Mikkonen, Santtu; Nieminen, Petteri; Grodzinsky, Alan J; Tanska, Petri; Korhonen, Rami K. 2024. Journal of orthopaedic research. 2025; 43: 70-83 A1 Journal article (refereed), original research -
Positive effects of acute N-acetylcysteine treatment simulated by an in silico model with overloading induced cell damage and recovery mechanisms
Kosonen, Joonas; Eskelinen, Atte; Orozco, Gustavo; Goetz, Jessica; Coleman, Mitchell; Grodzinsky, Alan; Anderson, Donald; Tanska, Petri; Korhonen, Rami. 2024. Annual meeting of the orthopaedic research society abstract -
Sensitivity of knee cartilage biomechanics in finite element analysis to selected Musculoskeletal models
Peitola, Joose PJ; Esrafilian, Amir; Eskelinen, Atte SA; Andersen, Michael S; Korhonen, Rami K. 2024. Computer methods in biomechanics and biomedical engineering. [Published online: 04 Jun 2024]: 1-12 A1 Journal article (refereed), original research -
Injury-related cell death and proteoglycan loss in articular cartilage: Numerical model combining necrosis, reactive oxygen species, and inflammatory cytokines
Kosonen, Joonas P.; Eskelinen, Atte S. A; Orozco, Gustavo A.; Nieminen, Petteri; Anderson, Donald D; Grodzinsky, Alan J; Korhonen, Rami K; Tanska, Petri. 2023. PLoS computational biology. 19: A1 Journal article (refereed), original research -
Knee cartilage mechanics in finite element analysis using inputs from different musculoskeletal software
Peitola, Joose; Esrafilian, Amir; Eskelinen, Atte; Skipper Andersen, Michael; Korhonen, Rami. 2023. abstract -
Multiscale In Silico Modeling of Cartilage Injuries
Korhonen, Rami K; Eskelinen, Atte SA; Orozco, Gustavo A; Esrafilian, Amir; Florea, Cristina; Tanska, Petri. Teoksessa: Connizzo, BK; Han, L; Sah, RL(toim.) , 2023. Electromechanobiology of Cartilage and Osteoarthritis : A Tribute to Alan Grodzinsky on his 75th Birthday. s. 45-56. Springer A3 Book section, Chapters in research books -
Biomechanics and inflammation - Regulators of articular cartilage degradation: Models aiming towards comprehensive prediction of post-traumatic osteoarthritis progression
Eskelinen, Atte. 2022. Publications of the University of Eastern Finland. Dissertations in Forestry and Natural Sciences G5 Doctoral dissertation (article) -
Cyclic loading regime considered beneficial does not protect injured and interleukin-1-inflamed cartilage from post-traumatic osteoarthritis
Eskelinen, Atte SA; Florea, Cristina; Tanska, Petri; Hung, Han-Hwa K.; Frank, Eliot H.; Mikkonen, Santtu; Nieminen, Petteri; Julkunen, Petro; Grodzinsky, Alan J.; Korhonen, Rami K.. 2022. Journal of biomechanics. 141: A1 Journal article (refereed), original research -
Reduction of pro-inflammatory cytokine activity results in proteoglycan content recovery in a computational model of injured articular cartilage implementing cytokines and reactive oxygen species
Kosonen, Joonas; Eskelinen, Atte; Orozco, Gustavo; Anderson, Donald; Grodzinsky, Alan; Tanska, Petri; Korhonen, Rami. 2022. Orthopaedic Research Society abstract -
Shear strain and inflammation-induced fixed charge density loss in the knee joint cartilage following ACL injury and reconstruction: A computational study
Orozco, Gustavo A; Eskelinen, Atte SA; Kosonen, Joonas P; Tanaka, Matthew S; Yang, Mingrui; Link, Thomas M; Ma, Benjamin; Li, Xiaojuan; Grodzinsky, Alan J; Korhonen, Rami K; Tanska, Petri. 2021. Journal of orthopaedic research