Christopher Asquith
Senior Researcher
Department of Pharmacy, Faculty of Health Sciences
School of Pharmacy, Faculty of Health Sciences
[email protected] | +358 50 400 3138
Chris Asquith is a Principal Investigator at the School of Pharmacy, University of Eastern Finland (UEF). The Asquith Research Lab focuses on the design, synthesis, and evaluation of small-molecule inhibitors targeting kinases within the understudied human kinome. The lab aims to uncover novel therapeutic opportunities by exploring previously uncharacterized kinase targets and their roles in disease.
Prior to his role at UEF, Chris held a Research Assistant Professor position in the Department of Pharmacology at the University of North Carolina (UNC), USA. During this time, he was part of the Illuminating the Druggable Genome (IDG) kinase program. He also worked as a postdoctoral researcher in the same department under the supervision of Prof. Gary Johnson, as well as in the School of Pharmacy under the supervision of Prof. Tim Willson within the Structural Genomics Consortium (SGC). Chris completed his PhD in Medicinal Chemistry at University College London (UCL), UK, and obtained his BSc and MSc in Chemistry from the University of Southampton, UK.
Research groups
Publications
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PIP4K2C: an emerging fulcrum for multiple diseases
Pozzetti, Luca; Mishra, Manjari; Einav, Shirit; Asquith, Christopher R. M., 2026, Nature reviews drug discovery, 25, 3, 166-166. B1 Non-refereed journal articles -
Medicinal chemistry applications of the Dimroth Rearrangement to the synthesis of biologically active compounds
Pozzetti, Luca; Pinhammer, Maja M; Asquith, Christopher RM, 2025, European journal of medicinal chemistry, 289, 117399. A2 Review article, Literature review, Systematic review -
Myeloid-specific CAMKK2 deficiency protects against diet-induced obesity and insulin resistance by rewiring metabolic gene expression and enhancing energy expenditure
Ortiz, Andrea R; Nay, Kevin; Stork, Brittany A; Dean, Adam M; Hartig, Sean M; Coarfa, Cristian; Tegegne, Surafel; Asquith, Christopher RM; Frigo, Daniel E; York, Brian; Means, Anthony R; Febbraio, Mark A; Scott, John W, 2025, Molecular metabolism, 101, 102250. A1 Journal article (refereed), original research -
PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2
Karim, Marwah; Mishra, Manjari; Lo, Chieh Wen; Saul, Sirle; Cagirici, Halise Busra; Gourdelier, Manon; Ghita, Luca; Ojha, Amrita; Tran, Do Hoang Nhu; Agrawal, Aditi; McGraw, Connor; East, Michael P; Gammeltoft, Karen Anbro; Sahoo, Malaya Kumar; Mooney, Nancie A; Johnson, Gary L; Das, Soumita; Leyssen, Pieter; Neyts, Johan; Chiu, Winston; Cohen, Courtney A; Bukh, Jens; Gottwein, Judith; Dye, John M; Neff, Norma; Jackson, Peter K; Pinsky, Benjamin A; Laitinen, Tuomo; Pantsar, Tatu; Poso, Antti; Za, 2025, Nature communications, 16, 1, 6397. A1 Journal article (refereed), original research -
Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships
Asquith, Christopher R M; East, Michael P; Laitinen, Tuomo; Alamillo-Ferrer, Carla; Hartikainen, Erkka; Wells, Carrow I; Axtman, Alison D; Drewry, David H; Tizzard, Graham J; Poso, Antti; Willson, Timothy M; Johnson, Gary L, 2024, European journal of medicinal chemistry, 271, 116357. A1 Journal article (refereed), original research -
Enhancing colistin efficacy against Salmonella infections with a quinazoline-based dual therapeutic strategy
Lobertti, Carlos A; Gizzi, Fernán O; Magni, Christian; Rial, Analía; Chabalgoity, José A; Yim, Lucía; Blancato, Víctor S; Asquith, Christopher R M; García Véscovi, Eleonora, 2024, Scientific reports, 14, 1, 5148. A1 Journal article (refereed), original research -
Pentathiepins are an understudied molecular prism of biological activities
Pozzetti, Luca; Asquith, Christopher RM, 2024, Archiv der pharmazie, 357, 12, 2400646. A2 Review article, Literature review, Systematic review -
TLK2: a target for cancer and viral latency
Pozzetti, Luca; East, Michael P; Laitinen, Tuomo; Asquith, Christopher RM, 2024, Nature reviews drug discovery, 23, 12, 886-886. B1 Non-refereed journal articles -
The Synthesis and Biological Applications of the 1,2,3-Dithiazole Scaffold
Kalogirou, Andreas S; Oh, Hans J; Asquith, Christopher RM, 2023, Molecules, 28, 7, 3193. A2 Review article, Literature review, Systematic review -
Utilization of Supervised Machine Learning to Understand Kinase Inhibitor Toxophore Profiles
Bieberich, Andrew A; Asquith, Christopher RM, 2023, International journal of molecular sciences, 24, 6, 5088. A1 Journal article (refereed), original research


