
Biomedical Spectroscopy Laboratory (biomedspect)
Research group
We are a multi-disciplinary research group of Engineers, Physicists, and Mathematicians focusing on applied spectroscopy and computational biophotonics. Our main aim is to adapt and translate optical and spectroscopic techniques and technology for clinical diagnostics of tissue pathologies.
Funder(s)
Main funder
Academy of Finland

Other funders
Jane and Aatos Erkko Foundation

Juselius Foundation

VTR - Kuopio University Hospital

Keywords
biomedical engineering
biophotonics
biophysics
bone
cartilage imaging
deep learning
machine learning
near infrared spectroscopy
photonics
raman spectroscopy
spectroscopy
translational research
Group members - UEF
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Isaac O. Afara Academy Research Fellow , Faculty of Science and Forestry, Department of Applied Physics
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Juha Töyräs Professor , Faculty of Science and Forestry, Department of Applied Physics
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Ervin Nippolainen Senior Researcher , Faculty of Science and Forestry, Department of Applied Physics
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Jari Torniainen Visiting Researcher , Faculty of Science and Forestry, Department of Applied Physics
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Arash Mirhashemi Haghighi Postdoctoral Researcher , Faculty of Science and Forestry, Department of Applied Physics
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Iman Kafian Attari Early Stage Researcher , Faculty of Science and Forestry, Department of Applied Physics
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Bilour Khan Early Stage Researcher , Faculty of Science and Forestry, Department of Applied Physics
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Karim Mahmoud Early Stage Researcher
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Awuniji Linus Early Stage Researcher
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Juho Ala-Myllymäki Grant-funded Researcher , Faculty of Science and Forestry, Department of Applied Physics
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Fatemeh Shahini Early Stage Researcher
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Eslam Shehata Visiting Researcher
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Godswill Ikegbu Project Researcher
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Adam Kositsky
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Omar Mahmoud Early Stage Researcher
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Teemu Laitinen Laboratory Engineer , Faculty of Science and Forestry, Department of Applied Physics
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Hannu Korhonen Laboratory Engineer , Faculty of Science and Forestry, Department of Applied Physics
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Jaakko Sarin Visiting Researcher , Faculty of Science and Forestry, Department of Applied Physics
Leader(s)
Professors
Senior Researchers
Post-doctoral Researchers
Doctoral Researchers
Supporting Staff
Others
Collaboration with UEF research groups
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Biophysics of Bone and Cartilage (BBC)
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Computational Spectral Imaging The group is a joint research group of the Scho...
Cooperation partners
Links
Publications
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Articular cartilage optical properties in the near-infrared (NIR) spectral range vary with depth and tissue integrity Khan, Bilour; Kafian-Attari, Iman; Nippolainen, Ervin; Shaikh, Rubina; Semenov, Dmitry; Hauta-Kasari, Markku; Töyräs, Juha; Afara, Isaac O.. 2021. Articular cartilage optical properties in the near-infrared (NIR) spectral range vary with depth and tissue integrity Biomedical optics express 12 10: 6066-6080. 2021
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Biomechanical, biochemical, and near infrared spectral data of bovine knee ligaments and patellar tendon Ristaniemi, Aapo; Torniainen, Jari; Paakkonen, Tommi; Stenroth, Lauri; Finnilä, Mikko A.J.; Tanska, Petri; Töyräs, Juha; Korhonen, Rami K.. 2021. Biomechanical, biochemical, and near infrared spectral data of bovine knee ligaments and patellar tendon Data in brief 36: 106976. 2021
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Characterization of connective tissues using near-infrared spectroscopy and imaging Afara, Isaac O; Shaikh, Rubina; Nippolainen, Ervin; Querido, William; Torniainen, Jari; Sarin, Jaakko K; Kandel, Shital; Pleshko, Nancy; Töyräs, Juha. 2021. Characterization of connective tissues using near-infrared spectroscopy and imaging Nature protocols 16 2: 1297-1329. 2021
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Dual-contrast computed tomography enables detection of equine posttraumatic osteoarthritis in vitro Saukko, AEA; Sarin, JK; Nykänen, O; Nissi, MJ; Te Moller, NCR; Weinans, H; Mancini, IAD; Visser, J; Brommer, H; van Weeren, PR; Malda, J; Grinstaff, MW; Töyräs, J. 2021. Dual-contrast computed tomography enables detection of equine posttraumatic osteoarthritis in vitro Journal of orthopaedic research 2022; 40 3: 703-711. 2021
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Functional and Structural Properties of Human Patellar Articular Cartilage in Osteoarthritis Nissinen, Mikko T; Hänninen, Nina; Prakash, Mithilesh; Mäkelä, Janne TA; Nissi, Mikko J; Töyräs, Juha; Nieminen, Miika T. Korhonen, Rami K; Tanska, Petri. 2021. Functional and Structural Properties of Human Patellar Articular Cartilage in Osteoarthritis Journal of biomechanics 126: 110634. 2021
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High-resolution infrared microspectroscopic characterization of cartilage cell microenvironment Linus, A; Ebrahimi, M; Turunen, MJ; Saarakkala, S; Joukainen, A; Kröger, H; Koistinen, A; Finnilä, M; Afara, IO; Mononen, ME; Tanska, P; Korhonen, RK. 2021. High-resolution infrared microspectroscopic characterization of cartilage cell microenvironment Acta biomaterialia 134: 252-260. 2021
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Infrared Fiber-Optic Spectroscopy Detects Bovine Articular Cartilage Degeneration Virtanen, Vesa; Nippolainen, Ervin; Shaikh, Rubina; Afara, Isaac O; Töyräs, Juha; Solheim, Johanne; Tafintseva, Valeria; Zimmermann, Boris; Kohler, Achim; Saarakkala, Simo; Rieppo, Lassi. 2021. Infrared Fiber-Optic Spectroscopy Detects Bovine Articular Cartilage Degeneration Cartilage 13 Suppl 2: 285S-294S. 2021
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Machine learning augmented near-infrared spectroscopy: In vivo follow-up of cartilage defects Sarin, Jaakko K; Te Moller, Nikae Cr; Mohammadi, Ali; Prakash, Mithilesh; Torniainen, Jari; Brommer, Harold; Nippolainen, Ervin; Shaikh, Rubina; Mäkelä, Janne Ta; Korhonen, Rami K; René van Weeren, P; Afara, Isaac O; Töyräs, Juha. 2021. Machine learning augmented near-infrared spectroscopy: In vivo follow-up of cartilage defects Osteoarthritis and cartilage 29 3: 423-432. 2021
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Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health Paakkari, Petri; Inkinen, Satu I; Honkanen, Miitu KM; Prakash, Mithilesh; Shaikh, Rubina; Nieminen, Miika T; Grinstaff, Mark W; Mäkelä, Janne TA; Töyräs, Juha; Honkanen, Juuso TJ. 2021. Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health Scientific reports 11 1: 5556. 2021
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Raman spectroscopy is sensitive to biochemical changes related to various cartilage injuries Shaikh, Rubina; Nippolainen, Ervin; Virtanen, Vesa; Torniainen, Jari; Rieppo, Lassi; Saarakkala, Simo; Afara, Isaac O; Töyräs, Juha. 2021. Raman spectroscopy is sensitive to biochemical changes related to various cartilage injuries Journal of raman spectroscopy 52 4: 796-804. 2021