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CorFlux´s Profile image


01.08.2022 - 31.12.2024
Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences

CorFlux project is funded by Business Finland and University of Eastern Finland and aims to be standard model in clinical assessment of Aortic Aneurysm (AA) rupture risk, create strong technological product development and develop a business model suitable for investors. Commercialisation goal is to create new business in Finland, do collaboration with other Finnish service and technology companies, enable international research and capital funding and create new health technology jobs in Finland.

The diagnosis, treatment and monitoring of aortic aneurysms cause significant costs for worldwide healthcare systems and economies. CorFlux analysis is a completely new approach for assessing the criticality of aortic aneurysms. The analysis will enable healthcare professionals to make decisions related to the treatment of aortic aneurysm patients much more accurately than the current practice.

At the moment AA is classified as dilated when the aortic diameter is >40mm. Patients with dilated aorta are usually scheduled for repeated follow up for the rest of their lives even though ~80% of the AA patients situation do not chance during the follow up. CorFlux analyse is based on clinical data and MRi and CT scans. The aortic digital twin simulation calculates the stresses in the aortic wall and estimates the Aortic rupture risk index. The result can be used as a clinical decision making tool to exclude the mild risk patients from the follow up and send only average risk patients to the follow up and high risk patients to the surgery or intensive follow up. This decreases the follow up costs significantly.


  • Marja Hedman, MD, professor, project leader
  • Matti Kurki, adjunct professor, principal researcher, mathematic simulation & digital analysis specialist
  • Pasi Karjalainen, PhD, professor physicist, business and regulation advisor
  • Tero Puustinen, MSc, business developer
  • Nora Rauhala, regulation specialist
  • Saara Sillanmäki, MD, PhD, research and imaging specialist
  • Lari Kujala, Bsc, study nurse

Steering group

  • Martti Heikkilä, CEO of Rehaco Ltd.
  • Jukka Tapaninen, CEO of Aiforia Ltd.
  • Tatu Juvonen, MD, PhD, professor
  • Arvo Kerajärvi, senior business advisor


  • Spark Finland


Kuopio University Hospital
PO BOX 100, 70029 KYS, Finland
Heart Center, Heart and lung surgery

  • Marja Hedman, MD, professor, cardiologist
  • Annastiina Husso, MD, PhD, heart surgeon
  • Antti Valtola, MD, adj. professor, heart surgeon
  • Juhana Toimela, MD, PhD researcher
  • Tarmo Korpela, BMSc, PhD researcher
  • Iida Viitala, MD, PhD researcher
  • Lari Kujala, BSc, study coordinator

Clinical Imaging Center
Clinical Radiology and Clinical Physiology and Nuclear Imaging

  • Petteri Kauhanen, MD, PhD, post doc researcher
  • Saara Sillanmäki, MD, PhD, post doc researcher
  • Line Lottonen-Raikaslehto, MD, PhD, post doc researcher
  • Minna Husso, MSc, PhD, hospital physicist
  • Elias Ylä-Herttuala, MSc, PhD, hospital physicist
  • Petri Saari, MD, PhD, vascular radiologist
  • Hanna Matikka, MSc, PhD, hospital physicist
  • Sami Väänänen, MSc, Phd, hospital physicist

Department of Anestesiology and Intensive care

  • Petri Toroi, BSc, study nurse
  • Maarit Lång, MD, PhD, clinical collaborator

University of Eastern Finland
PO BOX 1627, 70211 Kuopio, Finland
A.I.Virtanen Institute Molecular Sciences

  • Johanna Laakkonen, MSc, associate professor
  • Miika Kiema, MSc, researcher
  • Heta Rasinkangas, MSc, researcher
  • Akseli Kivistö-Rahnasto, MSc, researcher
  • Emma-Sofia Luoto, BMSc, researcher
  • Suvi Jauhiainen, BMSc, post doc researcher
  • Jussi Tohka, MSc, prof. of biomedical image analysis

Jyväskylä University of Applied Sciences
PO BOX 207, 40101 Jyväskylä, Finland
Industrial engineering

  • Matti Kurki, adjunct professor, principal researcher
  • Tero Tuovinen, adjunct professor, researcher
  • Tomi Nieminen, lector, researcher

Karolinska Institutet
17177 Stockholm, Sweden
Dept. of Molecular Medicine and Surgery

  • David Marlevi, MD, PhD, post doc researcher
  • Martin Ugander, MD, professor
  • Klara Blomdahl, MD, PhD researcher

University of Sydney

  • Martin Ugander, MD, professor

University of Haute-Alsace
Mulhouse, France

  • Frederic Heim, MS, professor