Kuopio Musculoskeletal Research Unit (KMRU) - UEFConnect

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Research group

01.05.2003 -

Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences

Information People

Leaders

Heikki Kröger

Professor

Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences

Kuopio Musculoskeletal Research Unit (KMRU) headed by Prof. Heikki Kröger, is a multidisciplinary research organization located at the Kuopio campus. In our interdisciplinary study group work specialists from several departments (orthopedics, gynaecology, internal medicine) and our study nurses have long-term experience in performing large clinical trials.

Our research interests include pathophysiology, genetics, epidemiology, exercise physiology, diagnosis, prevention and treatment of osteoporosis (and related fractures) and osteoarthritis. KMRU is closely linked with Department of Orthopaedics, Traumatology and Hand Surgery, Kuopio University Hospital. The core of the KMRU is the globally recognized Kuopio OSTPRE Study.

We also offer national and international bone and cartilage research services covering the whole chain from basic research to clinical trials.

Links

Projects

Cooperation

MD Ville Happonen
Incidence and complications of operatively treated ankle injuries in Finland between1986-2020 (2024)

MD Jeremi Heikkinen
Comorbidity and life satisfaction in ageing women with mental or musculoskeletal disorders (2023).

MD Ville Turppo
Validity of the Finnish Arthroplasty Register and outcomes of hip and knee arthroplasty (2023)

MD Tommi Vilpunaho
Methodological aspects of fall Prevention (2023)

MD Sarang Latif Qazi
Physical capacity, musculoskeletal health and well-being in postmenopausal women: with special focus on body composition, fractures, and life satisfaction (2022)

MD Miika Värri
Metabolic connections between osteoporosis, atherosclerosis and adipose tissue in postmenopausal women : the OSTPRE-BBA study (2022) (2021)

MD Iina Tuomainen
Preoperative predictors and surgical outcome in lumbar spinal stenosis : A prospective 10-year follow-up study (2021) (2021)

MD Nadia Afrin
Health-related predictors and outcomes of falls in postmenopausal women (2021)

MD Timo Nyyssönen
Achilles tendon rupture (2020)

MD Toni Tapaninen
Bone mineral density changes and histomorphometric findings after hip arthroplastic surgery (2019)

DSc Noora Airaksinen
Accidents among cyclists, moped drivers and motorcyclists – factors related to injuries and accident statistics (2018)

MSc Masod Isanejad
Nutrition and musculosceletal health among older people (2018)

MD Antti Jaroma
Assessment of bone after total knee arthroplasty (2018)

MD Simo Miettinen
Results and complications of large diameter head cementless metal-on-metal total hip arthroplasty and hip resurfacing arthroplasty (2018)

MD Xiaoyu Tong
Cortical bone histomorphometry – microarchitectural heterogeneity across anatomical sites in healthy males (2017)

MD Jaakko Järvenpää
Patient and operation related factors influencing the outcome of knee arthroplasty (2016)

MD Päivi Rauma
Associations between life satisfaction, depression, antidepressant use and bone (20Titles15)

MD Jarmo Saarelainen
Obesity and bone mineral measurements in postmenopausal women (2014)

MD Inari Tamminen
Assessment of bone quality in pediatric and adult patients with osteoporosis (2013)

MD Timo Aalto
Preoperative predictors and postoperative outpatient rehabilitation of lumbar spinal stenosis (2013)

PhD Toni Rikkonen
Physical activity and muscle atrength as predictors of bone loss and fractures in perimenopausal women (2012)

PhD Arto Koistinen
Improvement of orthopaedic bone screws by DLC coatings – in vitro methods for testing of screw fixation strength (2012)

MD Kati Pentti
Effects of hormone therapy and calcium supplementation on morbidity and mortality in postmenopausal women (2011)

MD Matti Kärkkäinen
Physical capacity and supplementation of vitamin D and calcium in postmenopausal women (2011)

MD Jyrki Nieminen
Effect of functional loadin on remodeling in canine, and normal and collagen type II transgenic murine bone (2009)

MD Antti Joukainen
New bioabsorbable implants for the fixation of metaphyseal bone (2008)

MD Janne Sahlman
Chondrodysplasias caused by defects in the col2a1 gene (2007)

MD Terhi Remes
Influences of genetic factors and regular exercise on bone in middle-aged men (2006)

PhD Mikko Hakulinen
Prediction of density, structure and mechanical properties of trabecular bone using ultrasound and x-ray techniques (2006)

MD Mikko Haara
Osteoarthritis and osteoporosis assessed from hand radiographs. Prevalence, determinants and association with morbidity and mortality (2006)

MD Jukka Huopio
Predicting fractures in middle-aged women (2005)

MD Tarja Soininvaara
Bone loss after total knee atrhroplasty (2005)

MD Kaisa Randell
Effects of hormonal and other factors on fractures in peri- and early postmenopausal women (2004)

MD Petri Venesmaa
Periprosthetic femoral bone loss and bone turnover after THA (2004)

MD Joonas Sirola
Early postmenopausal bone loss – population-based studies on risk and preventive factors and their interactions (2003)

MD Timo Salmen
Genetic influences of the sex steroid pathway on fracture risk (2002)

PhD Juha Töyräs
Mechano-acoustic characterization of articular cartilage and trabecular bone (2001)

MD Jouni Huuskonen
Osteoporosis in men (2001)

MD Pekka Arikoski
Metabolic bone disease in children with cancer (1999)

MD Marja Komulainen
Effect of HRT and vitamin D in prevention of osteoporosis (1999)

MD Antero Kotaniemi
Osteopenia associated with juvenile rheumatoid arthritis (1999)

MD Anna-Mari Heikkinen
Metabolic effects of prevention of osteoporosis in postmenopausal women with hormone replacement therapy and vitamin D3 (1998)

MD Marjo Tuppurainen
Osteoporosis risk factors and fractures among perimenopausal women (1995)
Seminar Series in Clinical Musculoskeletal Research / KMRU

The seminar series concentrates on clinical aspects of musculoskeletal research. The seminar consists of invited lectures and presentations of the post doctoral and graduate students. The main subjects deal with: bone biology, bone biomechanics, exercise physiology, fall prevention, osteoporosis, cartilage tissue, clinical research methods, clinical orthopedics. Seminar series takes place once bimonthly.

Persons in charge:
- Joonas Sirola, MD, PhD, Professor, joonas.sirola(at)kuh.fi
- Heikki Kröger, MD, PhD, Professor, heikki.kroger(at)kuh.fi
- Toni Rikkonen, MSc, PhD, Adjunct Professor, toni.rikkonen(at)uef.fi
1,5 ects (75% attendance, with own presentation 2 ects)
Further Information on Musculoskeletal Disorders
Other Links
- Link to bulletin “Not only bone density, but also quality of bone predicts fracture risk“
- Kuopio Osteoporosis Risk Factor and Prevention Study (see also publications)
- Department of Orthopaedics, Traumatology and Hand Surgery , Kuopio University Hospital
- Biophysics of Bone and Cartilage – research group
Postal address

University of Eastern Finland
Kuopio Musculoskeletal Research Unit
P.O. Box 1627
FI-70211 Kuopio
Finland

Mediteknia building

Leaders

Heikki Kröger

Professor

Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences

Professors

Senior Researchers

Doctoral Researchers

Tomi Nissinen

Grant-funded Researcher

Department of Technical Physics, Faculty of Science, Forestry and Technology

Supporting Staff

Seija Oinonen

Research Secretary

Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences

Research Nurses

Pirkko Kanerva

Clinical Research Nurse

Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences

Other group members

Inari Tamminen, MD, PhD
Päivi Rauma, Pharmacist, PhD
Jarmo Saarelainen, MD, PhD
Jukka Huopio, MD, PhD
Antti Joukainen, MD, PhD
Xiaoyu Tong, MD, PhD
Masoud Isanejad, MSc, PhD
Antti Jaroma, MD, PhD
Simo Miettinen, MD, PhD
Juho Kopra, MSc, PhD