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Kuopio Pediatric Research Unit (KUPRU)´s Profile image

Kuopio Pediatric Research Unit (KUPRU)

Research group
01.01.2022 -
Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences
Information People Publications

Leaders

In Kuopio Pediatric Research Unit (KUPRU) we perform multifaceted high-quality clinical and translational pediatric research aiming to increase health and wellbeing of children. KUPRU belongs to University of Eastern Finland and works in an immediate connection with Kuopio University Hospital.

Research Projects

  • Adrenarche – Increase of adrenal androgen secretion in childhood
    Group leader: Jarmo Jääskeläinen, professor, University of Eastern Finland and Kuopio University Hospital
  • Lower respiratory infections in children/Treatment of bronchiolitis and wheezy bronchitis
    Group leader: Marjo Renko, professor, University of Eastern Finland, Kuopio University Hospital and University of Oulu, PEDEGO research unit
  • Recognizing the type of dyspnea with smartphone motion sensors
    Group leader: Miika Arvonen, MD, PhD, Kuopio University Hospital
  • Fitness, nutrition and quality of life in children with inflammatory diseases  – juvenile arthritis and inflammatory bowel disease
    Group leaders: Eija Piippo-Savolainen, docent and Pekka Arikoski, docent, University of Eastern Finland and Kuopioi University Hospital
  • 3D printed simulator visualizing breathing difficulties and auscultation with digital tapes
    Group leader: Miika Arvonen, MD, PhD, Kuopio University Hospital
  • LBL 2018 – international treatment protocol for lymphoblastic lymphoma in children and adolescents
    Principal investigator in Finland: Kaisa Vepsäläinen, MD, PhD, Kuopio University Hospital
  • Epidemiology, pathogenesis and prognosis of PFAPA syndrome
    Group leader: Marjo Renko, professor, University of Eastern Finland, Kuopio University Hospital and University of Oulu, PEDEGO research unit
  • Congenital hypothyreosis
    Group leader: Jarmo Jääskeläinen, professor, University of Eastern Finland and Kuopio University Hospital
  • Neonatal glucose metabolism disorders
    Group leader: Hanna Huopio, docent, University of Eastern Finland and Kuopio University Hospital

 

  • 2019

    2018

  • 2020

    Arvonen M, Vänni P, Sarangi AN, V Tejesvi M, Vähäsalo P, Aggarwal A, Stoll ML. Microbial orchestra in juvenile idiopathic arthritis: Sounds of disarray? Immunol Rev. 2020 Mar;294(1):9-26. doi: 10.1111/imr.12826. Epub 2019 Dec 13.

    Bergroth E, Aakula M, Elenius V, Remes S, Piippo-Savolainen E, Korppi M, Piedra PA, Bochkov YA, Gern JE, Camargo CA Jr, Jartti T. Rhinovirus Type in Severe Bronchiolitis and the Development of Asthma. J Allergy Clin Immunol Pract. 2020 Feb;8(2):588-595.e4. doi: 10.1016/j.jaip.2019.08.043. Epub 2019 Sep 11.

    Grönlund MM, Remes-Pakarinen T, Kröger L, Markula-Patjas K, Backström M, Putto-Laurila A, Aalto K, Vähäsalo P. Efficacy and safety of tocilizumab in a real-life observational cohort of patients with polyarticular juvenile idiopathic arthritis. Rheumatology (Oxford). 2020 Apr 1;59(4):732-741. doi: 10.1093/rheumatology/kez291.

    Liimatta J1,2, Jääskeläinen J1,2, Karvonen AM3, Remes S1,2, Voutilainen R1,2, Pekkanen J3,4.Tracking of Serum DHEAS Concentrations from Age 1 to 6 Years: A Prospective Cohort Study.  J Endocr Soc. 2020 Feb 1;4(2):bvaa012. doi: 10.1210/jendso/bvaa012.

    Pasma H, Honkila M, Pokka T, Renko M, Salo E, Tapiainen T. Epidemiology of Kawasaki disease before and after universal Bacille Calmette-Guérin vaccinations were discontinued. Acta Paediatr. 2020 Apr;109(4):842-846. doi: 10.1111/apa.15012. Epub 2019 Oct 3.

    Renko M, Tapiainen T. Change in respiratory syncytial virus seasonality in Finland.  Acta Paediatr. 2020 Jan;109(1):202-203. doi: 10.1111/apa.14983. Epub 2019 Sep 16.

    Renko M, Vuopio J, Tapiainen T. Lasten vaikeat A-streptokokki-infektiot. Suomen Lääkäril 2020;75(4):179-184.

    Tapiainen T, Lantto U, Renko M. PFAPA-jaksokuume on lapsen tavallisin kuumeoireyhtymä. Duodecim 2020;136(9):1013-20.

    Korpela K, Renko M, Paalanne N, Vänni P, Salo J, Tejesvi M, Koivusaari P, Pokka T, Kaukola T, Pirttilä AM, Tapiainen T. Microbiome of the first stool after birth and infantile colic. Pediatr Res. 2020 Feb 13. doi: 10.1038/s41390-020-0804-y. [Epub ahead of print]

    2019

    Albertsen BK, Harila-Saari A, Jahnukainen K, Lähteenmäki P, Riikonen P, Möttönen M, Lausen B. Asparaginase treatment in infants with acute lymphoblastic leukemia; pharmacokinetics and asparaginase hypersensitivity in Interfant-06. Leuk Lymphoma 2019:60(6):1469-1475. 201900389.

    Arikoski P. Metso M. Lasten yö- ja päiväkastelu. Yleislääkäri 2019:34(5):9-12. 201900581.

    Becker S, Korpelainen S, Arvonen M, Hämäläinen S, Jantunen E, Lappalainen M, Pulkki K, Riikonen P, Juutilainen A. MMP-10 and TIMP-1 as indicators of severe sepsis in adult hematological patients with febrile neutropenia. Leuk Lymphoma. 2019 Dec;60(12):3036-3043. doi: 10.1080/10428194.2019.1617859. Epub 2019 May 24.

    Consolaro A, Giancane G, Alongi A, van Dijkhuizen EHP, Aggarwal A, Al-Mayouf SM, Bovis F, De Inocencio J, Demirkaya E, Flato B, Foell D, Garay SM, Lazăr C, Lovell DJ, Montobbio C, Miettunen P, Mihaylova D, Nielsen S, Orban I, Rumba-Rozenfelde I, Magalhães CS, Shafaie N, Susic G, Trachana M, Wulffraat N, Pistorio A, Martini A, Ruperto N, Ravelli A; Paediatric Rheumatology International Trials Organisation. Phenotypic variability and disparities in treatment and outcomes of childhood arthritis throughout the world: an observational cohort study. Lancet Child Adolesc Health. 2019 Apr;3(4):255-263. doi: 10.1016/S2352-4642(19)30027-6. Epub 2019 Feb 26. PMID:30819662.

    Helander H, Hovi M, Immonen T, Lähdesmäki T, Makkonen I, Saarenpää-Heikkilä O. Lasten ja nuorten krooninen
    väsymysoireyhtymä. Suomen Lääkärilehti 2019:74(18):1114-1120.

    Häkkinen MR, Murtola T, Voutilainen R, Poutanen M, Linnanen T, Koskivuori J, Lakka T, Jääskeläinen J, Auriola S. Simultaneous analysis by LC-MS/MS of 22 ketosteroids with hydroxylamine derivatization and underivatized estradiol from human plasma, serum and prostate tissue. J Pharm Biomed Anal. 2019 Feb 5;164:642-652. doi: 10.1016/j.jpba.2018.11.035.

    Karvonen AM, Kirjavainen PV, Täubel M, Jayaprakash B, Adams RI, Sordillo JE, Gold DR, Hyvärinen A, Remes S (LAST, OK133 Päätoimi), von Mutius E, Pekkanen J. Indoor bacterial microbiota and development of asthma by
    10.5 years of age. J Allergy Clin Immunol 2019:144(5):1402-1410.

    Kohva E, Huopio H, Hietamäki J, Hero M, Miettinen PJ, Raivio T. Treatment of gonadotropin deficiency during the first year of life: long-term observation and outcome in five boys. Hum Reprod. 2019 May 1;34(5):863-871. doi: 10.1093/humrep/dez040.

    Koskela M, Jahnukainen T, Endén K, Arikoski P, Kataja J, Nuutinen M, Ylinen E. Methylprednisolone or cyclosporine a in the treatment of Henoch-Schönlein nephritis: a nationwide study. Pediatr Nephrol 2019:34(8):1447-1456. 201900400.

    Kröger L, Löppönen T, Ala-Kokko L, Kröger H, Jauhonen HM, Lehti K, Jääskeläinen J. A novel mutation in the matrix metallopeptidase 2 coding gene associated with intrafamilial variability of multicentric osteolysis, nodulosis, and arthropathy. Mol Genet Genomic Med. 2019 Jul 3:e802. doi: 10.1002/mgg3.802.

    Kuiri-Hänninen T (LAST, OK133), Koskenniemi J, Dunkel L, Toppari J, Sankilampi U. Postnatal Testicular Activity in Healthy Boys and Boys With Cryptorchidism. Front Endocrinol 2019:10:489. 201900567.

    Leskinen S, Merras-Salmio S. Itkuinen imeväinen – milloin vatsavaivat ovat aihe lisätutkimuksiin? Yleislääkäri 2019:34(3):9-12.

    Liimatta J, Utriainen P, Laitinen T, Voutilainen R, Jääskeläinen J. Cardiometabolic Risk Profile Among Young Adult Females With a History of Premature Adrenarche. J Endocr Soc. 2019 Jul 15;3(10):1771-1783. doi: 10.1210/js.2019-00193. eCollection 2019 Oct 1. PMID: 31528825.

    Muukkonen L, Männistö J, Jääskeläinen J, Hannonen R, Huopio H. The effect of hypoglycaemia on neurocognitive outcome in children and adolescents with transient or persistent congenital hyperinsulinism. Dev Med Child Neurol. 2019 Apr;61(4):451-457. doi: 10.1111/dmcn.14039.

    Männistö JME, Jääskeläinen J, Huopio H. Health-Related Quality of Life in Children With Congenital Hyperinsulinism. Front Endocrinol (Lausanne). 2019 Oct 1;10:670. doi: 10.3389/fendo.2019.00670. eCollection 2019. PubMed PMID: 31632349; PubMed Central PMCID: PMC6779698.

    Mäntyselkä A, Haapala EA, Lindi V, Häkkinen MR, Auriola S, Jääskeläinen J, Lakka TA. Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood. Horm Res Paediatr. 2019;91(5):329-335. doi: 10.1159/000501719. Epub 2019 Aug 9. PubMed PMID: 31401625.

    Remes TM, Suo-Palosaari MH, Heikkilä V, Sutela AK, Koskenkorva PK, Toiviainen-Salo S, Porra L, Arikoski PM, Lähteenmäki PM, Pokka TM-L, Arola MO, Riikonen Pekka, Sirkiä KH, Lönnqvist TR, Rantala HM, Ojaniemi MK,       Harila-Saari AH. Radiation-Induced Meningiomas After Childhood Brain Tumor: A Magnetic Resonance Imaging Screening Study. J Adolesc Young Adult Oncol 2019:8(5):593-601. 201900700.

    Renko M, Lantto U, Tapiainen T. Towards better diagnostic criteria for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome. Acta Paediatr. 2019;108(8):1385-1392. doi: 10.1111/apa.14792. Review.

    Riikonen R, Kokki H. CSF nerve growth factor ([beta]-NGF) is increased but CSF insulin-like growth factor-(IGF-1) is normal in children with tuberous sclerosis and infantile spasms. Eur J Paediatr Neurol  2019:23(1):191-196. 201900188.

    Riikonen R, Lauhkonen E, Törmänen S, Backman K, Koponen P, Helminen M, Nuolivirta K, Korppi M. Prospective study confirms that bronchiolitis in early infancy increases the risk of reduced lung function at 10-13 years of age. Acta Paediatr 2019:108(1):124-130.  201900124.

    Riikonen R, Törmänen S, Saari A, Koponen P, Helminen M, Nuolivirta K, Korppi M, Lauhkonen E. Preliminary communication suggests overweight was associated with reduced lung function in adolescence after infant
    bronchiolitis. Acta Paediatr 2019:108(9):1729-1730. 201900553.

    Seppä S, Tenhola S, Voutilainen R. Fibroblast growth factor 21, adiponectin and irisin as markers of unfavorable metabolic features in 12-year-old children. J Endocr Soc 3(4):825-837, 2019 doi:  10.1210/js.2018-00399

    Seppä S, Tenhola S, Voutilainen R. Association of serum total osteocalcin concentrations with endogenous glucocorticoids and insulin sensitivity markers in 12-year-old children: a cross-sectional study. Front Endocrinol 10: 798, 2019  doi:  10.3389/fendo.2019.00798

    Tapiainen T, Koivusaari P, Brinkac L, Lorenzi HA, Salo J, Renko M, Pruikkonen H, Pokka T, Li W, Nelson K, Pirttilä AM, Tejesvi MV. Impact of intrapartum and postnatal antibiotics on the gut microbiome and emergence of antimicrobial resistance in infants. Sci Rep. 2019 Jul 23;9(1):10635. doi: 10.1038/s41598-019-46964-5.

    Tarkiainen M, Tynjälä P, Vähäsalo P, Kröger L, Aalto K, Lahdenne P. Health-related quality of life during early aggressive treatment in patients with polyarticular juvenile idiopathic arthritis: results from randomized controlled trial. Pediatr Rheumatol Online J. 2019 Dec 16;17(1):80. doi: 10.1186/s12969-019-0370-1.

    Tompuri TT, Jääskeläinen J, Lindi V, Laaksonen DE, Eloranta AM, Viitasalo A, Laitinen T, Lakka TA. Adiposity Criteria in Assessing Increased Cardiometabolic Risk in Prepubertal Children. Front Endocrinol (Lausanne). 2019 Jun 26;10:410. doi: 10.3389/fendo.2019.00410. eCollection 2019.

    Varimo T, Huopio H, Kariola L, Tenhola S, Voutilainen R, Toppari J, Toiviainen-Salo S, Hämäläinen E, Pulkkinen MA, Lääperi M, Tarkkanen A, Vaaralahti K, Miettinen PJ, Hero M, Raivio T. Letrozole versus testosterone for promotion of endogenous puberty in boys with constitutional delay of growth and puberty: a randomised controlled phase 3 trial. Lancet Child Adolesc Health. 2019 Feb;3(2):109-120. doi: 10.1016/S2352-4642(18)30377-8. Epub 2019 Jan 4.

    Ylinen MK, Tyni VE, Pihkala JI, Salminen JT, Sairanen H, Sarkola T. Procedural risk factors, incidence and timing of reintervention after treatment for native coarctation of the aorta in children: a population-based study? Eur J Cardiothorac Surg 2019:55(3):564-571. 201900381.

  • Kuopio Pediatric Research Unit

    University of Eastern Finland and Kuopio University Hospital

    Department of Pediatrics

    Building 6, 5th floor

    BOX 100

    70029 Kuopio, Finland

Keywords

clinical medicine

Leaders

Other group members

  • Miika Arvonen, LT, KYS
  • Kaisa Vepsäläinen,LT, lastentautien erikoislääkäri, lastenhemato-onkologi, KYS Lasten ja nuorten klinikka

Publications

16 items