Nutrigenomics and molecular nutrition

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Nutrigenomics and non-communicable or chronic diseases: Nutrigenomics is an emerging science in nutrition that uses molecular tools to better understand the physiological responses obtained through a certain diet in individuals and population groups.

At the Institute of Public Health and Clinical Nutrition, within the main research interests of the nutrigenomics research line is to study the molecular interactions between metabolites produced by the gut microbiota derived from specific dietary nutrients that protect from type 2 diabetes and non-alcoholic fatty liver disease under this specific project

Leaders

Project name

• Molecular and metabolic mechanisms for the role of gut microbiota-derived indole propionic acid (IPA) in the prevention of type 2 diabetes

Other projects:

• Studying the gene-pathway associations for IPA both for adipose and liver tissues.

PhD student
Ratika Sehgal, Ratika.Sehgal@uef.fi

Post Doc researcher
Mariana Ilha, Mariana.Ilha@uef.fi
Marjo Tuomainen, Marjo.Tuomainen@uef.fi

Cooperation

Prof. Jussi Pihlajamäki

UEF (transcriptomics and epigenetic studies, FADSDIET2 study)
Prof. Kirsi Virtanen

UEF (PET study)
Prof. Ursula Schwab

UEF (dietary intervention studies)
Emeritus Profs: Matti Uusitupa and Jaakko Tuomilehto

Finnish Diabetes Prevention Study
Dr. Kati Hanhineva

UEF (non-targeted metabolomics studies)
Prof. Charlotte Ling, Lund University

(DNA methylation studies)
Prof. Stine Ulven, Oslo University

(PBMC transcriptomics studies)
Prof. Rikard Landberg

Chalmers University of Technology, Sweden
Prof. Cristiane Leitão

UFRGS, Brazil (nutritional, dietary and metabolic aspects in obesity and non-alcoholic fatty liver disease)
Dr. Márcio Flávio Moura de Araújo

nursing sciences, UNILAB/Fortaleza
Dr. Luciana Vercoza Viana

Endocrinology and Nutrology sciences, HCPA/UFRGS, Porto Alegre, Brazil
Dr. Thais Steemburgo

Course in Nutrition Genomics in non-communicable chronic diseases, UFRGS, Post-Graduation Program in Nutrition and Health, Brazil
Dr. Helen Hermana M. Hermsdorff

Nutrition and health, UFV/Viçosa, Brazil

The Physical Activity and Nutrition in Children (PANIC) study 01.01.2007 -

Leaders

Publications

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Nutrigenomics and molecular nutrition

Leaders

Cooperation

Leaders

Cost-Effectiveness of Passion Fruit Albedo versus Turmeric in the Glycemic and Lipaemic Control of People with Type 2 Diabetes: Randomized Clinical Trial

Intake of Camelina Sativa Oil and Fatty Fish Alter the Plasma Lipid Mediator Profile in Subjects with Impaired Glucose Metabolism - A Randomized Controlled Trial

Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids

An Isocaloric Nordic Diet Modulates RELA and TNFRSF1A Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome-A SYSDIET Sub-Study

Camelina sativa Oil, Fatty Fish, and Lean Fish Do Not Markedly Affect Urinary Prostanoids in Subjects with Impaired Glucose Metabolism

Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with the Metabolic Syndrome - A SYSDIET Sub-Study

Liver DNA methylation of FADS2 associates with FADS2 genotypex

The effect of different sources of fish and camelina sativa oil on immune cell and adipose tissue mRNA expression in subjects with abnormal fasting glucose metabolism: a randomized controlled trial

Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression

Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals

Camelina Sativa Oil, but not Fatty Fish or Lean Fish Improved Serum Lipid Profile in Subjects with Impaired Glucose Metabolism - a Randomized Controlled Trial

Intake of Fatty Fish Alters the Size and the Concentration of Lipid Components of HDL Particles and Camelina Sativa Oil Decreases IDL Particle Concentration in Subjects with Impaired Glucose Metabolism

Serum Adiponectin/Ferritin Ratio in Relation to the Risk of Type 2 diabetes and Insulin Sensitivity

Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD

Sex Differences in the Methylome and Transcriptome of the Human Liver and Circulating HDL-Cholesterol Levels

The effect of camelina sativa oil and fish intakes on fatty acid compositions of blood lipid fractions

Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver

Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes

Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study

DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk

Effect of a 2-y dietary and physical activity intervention on plasma fatty acid composition and estimated desaturase and elongase activities in children: the Physical Activity and Nutrition in Children Study

Effects of a healthy Nordic diet on gene expression changes in peripheral blood mononuclear cells in response to an oral glucose tolerance test in subjects with metabolic syndrome: a SYSDIET sub-study

Epigenetic alterations in blood mirror age-associated DNA methylation and gene expression changes in human liver

Reduction in cardiometabolic risk factors by a multifunctional diet is mediated via several branches of metabolism as evidenced by non-targeted metabolite profiling approach

Cross-sectional associations of plasma fatty acid composition and estimated desaturase and elongase activities with cardiometabolic risk in Finnish children - The PANIC study

Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels

Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men

Glucose Metabolism Effects of Vitamin D in Prediabetes: the VitDmet Randomized Placebo-Controlled Supplementation Study

Longitudinal associations of serum fatty acid composition with type 2 diabetes risk and markers of insulin secretion and sensitivity in the Finnish Diabetes Prevention Study

Markers of cholesterol metabolism as biomarkers in predicting diabetes in the Finnish Diabetes Prevention Study

Relevance of Vitamin D Receptor Target Genes for Monitoring the Vitamin D Responsiveness of Primary Human Cells

Associations of erythrocyte membrane fatty acids with the concentrations of C-reactive protein, interleukin 1 receptor antagonist and adiponectin in1373 men

Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individuals

Cross-Sectional Associations of Food Consumption with Plasma Fatty Acid Composition and Estimated Desaturase Activities in Finnish Children

DNA methylation in obesity and type 2 diabetes

Dissecting high from low responders in a vitamin D3 intervention study

Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome

Nontargeted metabolite profiling discriminates diet-specific biomarkers for consumption of whole grains, fatty fish, and bilberries in a randomized controlled trial

Primary vitamin D receptor target genes as biomarkers for the vitamin D3 status in the hematopoietic system

Effect of fatty and lean fish intake on lipoprotein subclasses in subjects with coronary heart disease: A controlled trial

Primary vitamin D target genes allow a categorization of possible benefits of vitamin D3 supplementation

Gene expression of peripheral blood mononuclear cells as a tool in dietary intervention studies: What do we know so far?

Insulin secretion and its determinants in the progression of impaired glucose tolerance to type 2 diabetes in impaired glucose-tolerant individuals: the finnish diabetes prevention study

Leukocyte Telomere Lenght in the Finnish Diabetes Prevention Study

A diet high in fatty fish, bilberries and wholegrain products improves markers of endothelial function and inflammation in individuals with impaired glucose metabolism in a randomised controlled trial: The Sysdimet study

High dietary glycemic index and low fiber content are associated with metabolic syndrome in patients with type 2 diabetes

Gene Expression of FTO in Human Subcutaneous Adipose Tissue, Peripheral Blood Mononuclear Cells and Adipocyte Cell Line.

Fibras na dieta: tendencias atuais e benefícios à saúde na síndrome metabólica e no diabetes melito tipo 2. Dietary fibers: current trents and health benefits in the metabolic syndrome and type 2 diabetes

Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease

Papel do indice glimemico e da carga glicemica na prevencao e no controle metabolico de pacientes com daibetes melito tipo 2.Glycemic index and glycemic load in the prevention and treatment of type 2 diabetes mellitus

The effect of fatty or lean fish intake on inflammatory gene expression in peripheral blood mononuclear cells of patients with coronary heart disease

Dietary fatty acids and cardiovascular disease: an epidemiological approach

Downregulation of genes involved in NFkappaB activation in peripheral blood mononuclear cells after weight loss is associated with the improvement of insulin sensitivity in individuals with the metabolic syndrome: the GENOBIN study

Effect of weight loss on cytokine messenger RNA expression in peripheral blood mononuclear cells of obese subjects with the metabolic syndrome

Effects of fatty and lean fish intake on blood pressure in subjects with coronary heart disease using multiple medications

Expression of ghrelin gene in peripheral blood mononuclear cells and plasma ghrelin concentrations in patients with metabolic syndrome