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Pain Neuromodulation Group´s Profile image

Pain Neuromodulation Group

Research group
01.01.2022 -
Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences


    Research Goals

    • To evaluate the long-term outcome of neuromodulation therapies in chronic neuropathic pain using comprehensive patient and family data from medical records and national registries. We combine this data with objective monitoring of quality of sleep and physical activity.
    • To improve neuromodulation outcome in chronic neuropathic pain by developing algorithms for optimizing patient selection and treatment.
    • To investigate mechanisms of pain chronification and molecular effect of different neuromodulation therapies with activity-based protein profiling of serine hydrolases from CSF and blood.

    Scientific and Societal Impact of Research

    We expect that this research will produce extensive novel quantitative data on the use of drugs, comorbidities, quality of life, and familiality of chronic pain. This allows creation of new biomarkers to improve patient selection and to tailor the neuromodulation therapies for each patient based on their individual biological characteristics. Furthermore, results from mass-spectrometry and enzyme activity measurements are expected to increase the knowledge from mechanisms and may serve new targets for pain treatment.


    Kuopio University Hospital State Research Funding, Medtronic Research Grant.




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