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Physical Activity, Fitness, and Sedentariness with MEtabolic, VAscular, and Cardiac health in pediatric population (PAFSMEVAC)´s Profile image

Physical Activity, Fitness, and Sedentariness with MEtabolic, VAscular, and Cardiac health in pediatric population (PAFSMEVAC)

Project
01.01.2020 - 31.12.2035
Institute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences

Funders

Main funder

Finnish Cultural Foundation

Physical Activity, Fitness, and Sedentariness with MEtabolic, VAscular, and Cardiac health in pediatric population (PAFSMEVAC) funder logo

Other funders

Physical Activity, Fitness, and Sedentariness with MEtabolic, VAscular, and Cardiac health in pediatric population (PAFSMEVAC) funder logo Physical Activity, Fitness, and Sedentariness with MEtabolic, VAscular, and Cardiac health in pediatric population (PAFSMEVAC) funder logo Physical Activity, Fitness, and Sedentariness with MEtabolic, VAscular, and Cardiac health in pediatric population (PAFSMEVAC) funder logo Physical Activity, Fitness, and Sedentariness with MEtabolic, VAscular, and Cardiac health in pediatric population (PAFSMEVAC) funder logo Physical Activity, Fitness, and Sedentariness with MEtabolic, VAscular, and Cardiac health in pediatric population (PAFSMEVAC) funder logo Physical Activity, Fitness, and Sedentariness with MEtabolic, VAscular, and Cardiac health in pediatric population (PAFSMEVAC) funder logo Physical Activity, Fitness, and Sedentariness with MEtabolic, VAscular, and Cardiac health in pediatric population (PAFSMEVAC) funder logo Physical Activity, Fitness, and Sedentariness with MEtabolic, VAscular, and Cardiac health in pediatric population (PAFSMEVAC) funder logo

Leaders

The PAFSMEVAC project aims to:

  1. Improve understanding of the development of cardiovascular, metabolic, and arterial diseases from childhood until young adulthood.
  2. Identify critical time period of significant deviation from physiology to pathology during growth and maturation.
  3. Simulate potential intervention effects in situation were randomized clinical trials are lacking in apparently healthy children and adolescents.
  4. Examine mechanistic cross-talk within modifiable risk factors and non-modifiable risk factors to inform potentially effective intervention strategies.
  5. Investigate causal inferences in risk factors relationships that prospectively influence cardiac, metabolic, and arterial health from childhood through young adulthood.
  6. Discover novel risk factors for several paediatric diseases such as hypertension, insulin resistance (type 2 diabetes), obesity, premature cardiac damage, atherosclerosis, dyslipidaemia in which several intervention strategies have had limited success.
  7. To fill knowledge gaps identified by the World Health Organization and other global public health agencies through the provision of substantial scientific evidence useful in updating health guidelines in primarily preventing non-communicable diseases.

Modifiable risk factors are total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, insulin resistance (glucose and insulin), blood pressure, heart rate, low-grade inflammation, obesity, body composition (fat mass and muscle mass), sedentary time, light physical activity, moderate-to-vigorous physical activity, smoking habit, cardiorespiratory fitness. Risk factors where measured during clinic visit from childhood starting at age 7 years and repeated either yearly or bi-annually until age 17 years. Young adulthood assessments occurred at age 24 years clinic visit, the 30-year clinic visit is currently ongoing (2022 – 2024).

The major study outcomes are: arterial stiffness (carotid-femoral pulse wave velocity), carotid intima-media thickness, carotid elasticity or distensibility, left ventricular concentric and eccentric hypertrophy, left ventricular diastolic function, left ventricular filling pressure, etc. These cardiac and vascular outcomes were measured both in adolescence (age 17 years) and young adulthood (age 24 years).

Data and Population Size:

Data for urFIT-child research project are drawn from the Avon Longitudinal Study of Parents and Children (ALSPAC), also known as Children of the 90s, a world-leading UK ongoing birth cohort study. More than 14,000 pregnant women were recruited from April 1991 through December 1992 and 14,901 foetuses arising from the pregnancy, and their partners have been followed up intensively over three decades. The ALSPAC study website contains details of all the data that are available (http://www.bristol.ac.uk/alspac/researchers/our-data/).

Population who attended specific clinic visits:

Clinic visit        Population sample size
@Age 7 years:         8 290

@Age 8 years:         7 488

@Age 9 years:         7 722

@Age 10+ years:    7 557

@Age 11+ years:    7 153

@Age 12+ years:   6 832

@Age 13+ years:   6 147

@Age 15+ years:   5 515

@Age 17+ years:   5 081

@Age 24+ years:  4 026

@Age 30+ years:  ongoing

 

Impact:

To disseminate findings in high impact and leading scientific journals in addition to providing simple texts (press release) understandable to the general population and tax payers who have funded the research. This evidence would be helpful in updating public health recommendation from childhood to enable a healthier life course.

 

News

Cooperation

  • The urFIT-child project research proposals are listed below but not limited to:

    Cardiorespiratory fitness, adiposity and lean mass in relation to arterial structure and function from childhood to adulthood

    https://proposals.epi.bristol.ac.uk/?q=node/130051

    Associations between sedentary time and physical activity with arterial function and structure from childhood to adulthood

    https://proposals.epi.bristol.ac.uk/?q=node/130208

    Associations of cardiorespiratory fitness, body composition, physical activity and sedentary time with cardiometabolic risks

    https://proposals.epi.bristol.ac.uk/?q=node/130309

    Youth Vascular Consortium

    https://proposals.epi.bristol.ac.uk/?q=node/130322

    Association of inflammation with cardiac structure in adolescents

    https://proposals.epi.bristol.ac.uk/?q=node/130952

  • Agbaje AO. Mediating effect of fat mass, lean mass, blood pressure and insulin resistance on the associations of accelerometer-based sedentary time and physical activity with arterial stiffness, carotid IMT and carotid elasticity in 1574 adolescents. J Hum Hypertens. 2024 Feb 26. https://doi.org/10.1038/s41371-024-00905-6

    Agbaje AO, Saner C, Zhang J, Henderson M, Tuomainen TP. DEXA-based Fat Mass with the Risk of Worsening Insulin Resistance in Adolescents: A 9-Year Temporal and Mediation Study. J Clin Endocrinol Metab. 2024 Jan 4:dgae004. https://doi.org/10.1210/clinem/dgae004 Epub ahead of print. PMID: 38173399.

    Agbaje AO. Increasing lipids with risk of worsening cardiac damage in 1595 adolescents: A 7-year longitudinal and mediation study. Atherosclerosis. 2024 Feb 1:389;117440. https://doi.org/10.1016/j.atherosclerosis.2023.117440

  • Agbaje AO, Perng W, Tuomainen TP. Effects of accelerometer-based sedentary time and physical activity on DEXA-measured fat mass in 6059 children. Nature Communications. 2023 Dec 12;14(1):8232. https://doi.org/10.1038/s41467-023-43316-w

    Agbaje AO. Associations of Sedentary Time and Physical Activity From Childhood With Lipids: A 13-Year Mediation and Temporal Study. J Clin Endocrinol Metab. 2023 Dec 14:dgad688. https://doi.org/10.1210/clinem/dgad688 Epub ahead of print. PMID: 38097375.

    A O Agbaje, A R Barker, A J Lewandowski, P Leeson, T P Tuomainen. Cumulative accelerometer-based sedentary time from childhood through young adulthood with increased arterial stiffness and carotid intima-media thickness in youth: a 13-year longitudinal study. European Heart Journal 2023 Nov 2;44(Supplement_2):ehad655.2077. https://doi.org/10.1093/eurheartj/ehad655.2077

    A O Agbaje, A R Barker, A J Lewandowski, P Leeson, T P Tomi-Pekka. Cumulative accelerometer-based light physical activity from childhood through young adulthood with arterial stiffness and carotid intima-media thickness progression: a 13-year longitudinal study. European Heart Journal 2023 Nov 2;44(Supplement_2):ehad655.2338. https://doi.org/10.1093/eurheartj/ehad655.2338

    A O Agbaje. Cumulative accelerometer-based sedentary time from childhood through young adulthood with progressive left ventricular remodelling in British youth: a 13-year longitudinal study. European Heart Journal 2023 Nov 2;44(Supplement_2):ehad655.2393. https://doi.org/10.1093/eurheartj/ehad655.2393

    A O Agbaje. Prospective associations of non-HDL cholesterol with premature structural and functional cardiac damage progression in British youth: the ALSPAC study. European Heart Journal 2023 Nov 2;44(Supplement_2):ehad655.3017. https://doi.org/10.1093/eurheartj/ehad655.3017

    A O Agbaje. Cumulative accelerometer-based light physical activity from childhood through young adulthood progressively decreases left ventricular mass in British youth: a 13-year longitudinal study. European Heart Journal 2023 Nov 2;44(Supplement_2):ehad655.1139. https://doi.org/10.1093/eurheartj/ehad655.1139

    A O Agbaje. Increased triglyceride independently associates with premature structural and functional cardiac damage progression in asymptomatic adolescents: a 7-year longitudinal study. European Heart Journal 2023 Nov 2;44(Supplement_2):ehad655.2502. https://doi.org/10.1093/eurheartj/ehad655.2502

    A O Agbaje. A 7-year longitudinal association of total cholesterol with premature structural and functional cardiac damage progression in youth: the ALSPAC birth cohort study. European Heart Journal 2023 Nov 2;44(Supplement_2):ehad655.1138. https://doi.org/10.1093/eurheartj/ehad655.1138

    A O Agbaje. An average of 60mins/day of moderate to vigorous physical activity from childhood through young adulthood was associated with worsening cardiac structural damage in youth: A 13-year longitudinal study. European Heart Journal 2023 Nov 2;44(Supplement_2):ehad655.2602. https://doi.org/10.1093/eurheartj/ehad655.2602

    A O Agbaje. Longitudinal Associations of Accelerometer-Based Sedentary Time and Physical Activity With Blood Pressure Progression From Childhood Through Young Adulthood: A 13-year Mediation and Isotemporal Substitution Study of 2513 Children. Circulation. 2023 Nov 6;148:A16549. https://www.ahajournals.org/doi/10.1161/circ.148.suppl_1.16549

    Agbaje AO, Zachariah JP, Tuomainen TP. Arterial Stiffness but not Carotid Intima-Media Thickness Progression Precede Premature Structural and Functional Cardiac Damage in Youth: A 7-Year Temporal and Mediation Longitudinal Study. Atherosclerosis 2023 Sep;380:117197. https://doi.org/10.1016/j.atherosclerosis.2023.117197

    Agbaje AO. Associations of accelerometer-based sedentary time, light physical activity and moderate-to-vigorous physical activity with resting cardiac structure and function in adolescents according to sex, fat mass, lean mass, BMI, and hypertensive status. Scand J Med Sci Sports. 2023 Aug;33(8):1399-1411. doi: 10.1111/sms.14365.

    Agbaje AO. Adolescents Cholesterol Passport: A Universal Pediatric Lipid Screening Tool to Combat Atherosclerosis – the World’s Deadliest Scourge. Front Pediatr. 2023 June 19;11. doi: 10.3389/fped.2023.1228483

    Agbaje AO. Longitudinal Mediating effect of Fatmass and Lipids on Sedentary Time, Light PA, and MVPA with Inflammation in Youth. J Clin Endocrinol Metab. 2023 Jun 13:dgad354. doi: 10.1210/clinem/dgad354. Epub ahead of print. PMID: 37310686.

    Agbaje AO. Arterial stiffness preceding metabolic syndrome in 3,862 adolescents: a mediation and temporal causal longitudinal birth cohort study. Am J Physiol Heart Circ Physiol. 2023 Jun 1;324(6):H905-H911. doi: 10.1152/ajpheart.00126.2023.

    Agbaje AO. Does arterial stiffness mediate or suppress the associations of blood pressure with cardiac structure and function in adolescents?. Am J Physiol Heart Circ Physiol. June 1 2023;324(6):H776-H781. doi: 10.1152/ajpheart.00094.2023.

    Agbaje AO. Longitudinal Left Ventricular Mass Indexing for DEXA-Measured Lean Mass and Fat Mass: Novel Normative Reference Centiles in Post-Pubertal Adolescents and Young Adults. American Journal of Physiology-Heart and Circulatory Physiology 2023, Apr 1;324(4):H571-H577. https://doi.org/10.1152/ajpheart.00045.2023

    Agbaje AO, Barker AR, Tuomainen TP. Cumulative muscle mass and blood pressure but not fat mass drives arterial stiffness and carotid intima-media thickness progression in the young population and is unrelated to vascular organ damage. Hypertension Research April 1 2023;46:984–999. doi: 10.1038/s41440-022-01065-1.

    Agbaje AO. Elevated Blood Pressure and Worsening Cardiac Damage During Adolescence. The Journal of Pediatrics. 2023 Mar 3:S0022-3476(23)00132-4. doi: 10.1016/j.jpeds.2023.02.018.

    Agbaje AO, Zachariah JP, Bamsa O, Odili AN, and Tuomainen T-P. Cumulative insulin resistance and hyperglycaemia with arterial stiffness and carotid IMT progression in 1779 adolescents: A 9-Year Longitudinal Cohort Study. American Journal of Physiology-Endocrinology and Metabolism 2023 Mar 1;324(3):E268-E278. https://doi.org/10.1152/ajpendo.00008.2023

    Agbaje AO, Barmi S, Sansum KM, Baynard T, Barker AR, and Tuomainen T-P. Temporal longitudinal associations of carotid-femoral pulse wave velocity and carotid intima-media thickness with resting heart rate and inflammation in youth. Journal of Applied Physiology 2023 Mar 1;134(3):657-666. https://doi.org/10.1152/japplphysiol.00701.2022

    Agbaje AO, Lloyd-Jones DM, Magnussen CG, Tuomainen T-P. Cumulative Dyslipidemia with Arterial Stiffness and Carotid IMT Progression in Asymptomatic Adolescents: A Simulated Intervention Longitudinal Study Using Temporal Inverse Allocation Model. Atherosclerosis Jan 1 2023;364:39-48. https://doi.org/10.1016/j.atherosclerosis.2022.11.011

  • Agbaje AO. Cardiorespiratory Fitness in Adolescence: A Telescope into Future Cardiovascular Health. Eur J Prev Cardiol. 2022 Dec 13:zwac298. doi: 10.1093/eurjpc/zwac298.

    Andrew O Agbaje, Justin P Zachariah, and Tomi-Pekka Tuomainen. Arterial Stiffness and Carotid Intima-Media Thickness Progression Preceding Worsening Left Ventricular Hypertrophy and Diastolic Dysfunction in Youth: A Temporal Causal Longitudinal Study. Circulation 2022, Oct 30. doi/10.1161/circ.146.suppl_1.13679

    Agbaje AO. To prevent hypertension in Africans: do we need to eat more vegetables? Eur J Prev Cardiol. 2022 Oct 10:zwac233. doi: 10.1093/eurjpc/zwac233.

    A O Agbaje, D M Lloyd-Jones, C G Magnussen, T P Tuomainen. Cumulative dyslipidaemia from mid-adolescence through young adulthood with carotid intima-media thickness progression: a 9-year longitudinal study. European Heart Journal, 2022 Oct 2:43(Supplement_2,); ehac544.2350, https://doi.org/10.1093/eurheartj/ehac544.2350

    A O Agbaje, S Barmi, K M Sansum, T Baynard, A R Barker, T P Tuomainen. Does arterial stiffness progression temporally precede higher low-grade inflammation in adolescents? Causal longitudinal evidence using auto-regressive cross-lagged structural equation models. European Heart Journal, 2022 Oct 2:43(Supplement_2,);ehac544.2247. https://doi.org/10.1093/eurheartj/ehac544.2247

    A O Agbaje, D M Lloyd-Jones, C G Magnussen, T P Tuomainen. Simulated intervention and optimal timing for attenuating dyslipidaemia-related atherosclerotic progression in the young: a temporal inverse allocation analysis of the ALSPAC cohort. European Heart Journal, 2022 Oct 2:43(Supplement_2,); ehac544.2352, https://doi.org/10.1093/eurheartj/ehac544.2352

    A O Agbaje, S Barmi, K M Sansum, T Baynard, A R Barker, T P Tuomainen. Temporal causal longitudinal associations of high-sensitivity C-reactive protein with carotid intima-media thickness progression in adolescents: the ALSPAC birth cohort study. European Heart Journal, 2022 Oct 2:43(Supplement_2,); ehac544.2246, https://doi.org/10.1093/eurheartj/ehac544.2246

    A O Agbaje, J P Zachariah, O Bamsa, A N Odili, T P Tuomainen. Cumulative hyperinsulinemia, hyperglycaemia, and insulin resistance from mid-adolescence through young adulthood with carotid intima-media thickness progression: a 9-year longitudinal study. European Heart Journal, 2022 Oct 2:43(Supplement_2,);ehac544.2414, https://doi.org/10.1093/eurheartj/ehac544.2414

    A O Agbaje, D M Lloyd-Jones, C G Magnussen, T P Tuomainen. Longitudinal associations of cumulative dyslipidaemia from mid-adolescence through young adulthood with arterial stiffness progression: the ALSPAC study. European Heart Journal, 2022 Oct 2:43(Supplement_2,);ehac544.2351, https://doi.org/10.1093/eurheartj/ehac544.2351

    Agbaje AO. Mediating role of body composition and insulin resistance on the association of arterial stiffness with blood pressure among adolescents: The ALSPAC study. Front. Cardiovasc. Med. 2022: 9:939125. doi: 10.3389/fcvm.2022.939125

    Agbaje AO. Arterial stiffness precedes hypertension and metabolic risks in youth: a review. J Hypertens. 2022 Oct 1;40(10):1887-1896. . doi: 10.1097/HJH.0000000000003239.

    Agbaje AO, Barker AR, Mitchell GF, Tuomainen TP. Effect of Arterial Stiffness and Carotid Intima-Media Thickness Progression on the Risk of Dysglycemia, Insulin Resistance, and Dyslipidemia: a Temporal Causal Longitudinal Study. Hypertension. 2022 Mar;79(3):667-678. doi: 10.1161/HYPERTENSIONAHA.121.18754.

    Agbaje AO, Barker AR, Tuomainen TP. Effects of Arterial Stiffness and Carotid Intima-Media Thickness Progression on the Risk of Overweight/Obesity and Elevated Blood Pressure/Hypertension: a Cross-Lagged Cohort Study. Hypertension. 2022 Jan;79(1):159-169. doi: 10.1161/HYPERTENSIONAHA.121.18449.

    Agbaje AO, Barker AR, Tuomainen TP. Cardiorespiratory Fitness, Fat Mass, and Cardiometabolic Health with Endothelial Function, Arterial Elasticity, and Stiffness. Med Sci Sports Exerc. 2022 Jan 1;54(1):141-152. doi: 10.1249/MSS.0000000000002757.

  • Central Finnish Cultural Foundation

    Jenny and Antti Wihuri Foundation

    The North Savo regional Finnish Cultural Foundation

    Orion Research Foundation sr

    Aarne Koskelo Foundation

    Antti and Tyyne Soininen Foundation

    Paulo Foundation

    Paavo Nurmi Foundation

    Yrjö Jahnsson Foundation

    Finnish Foundation for Cardiovascular Research

    Pediatric Research Foundation

    Ida Montin Foundation

    Eino Räsänen Fund

    Matti and Vappu Maukonen Fund

    Alfred Kordelin Foundation

Publications

46 items