Randomized Controlled Trials in Substance Dependence and Antisocial Behavior

Group leader is professor Jari Tiihonen.

Research topics and goals:

• To find new effective pharmacological treatments for illicit drug dependence
• To study the efficacy of pharmacological treatment for psychopathy

Latest achievements:

• The results from Tiihonen et al. 2012 (Am J Psychiatry) provided the first evidence from a randomized controlled trial of an effective pharmacological treatment for polysubstance dependence.

Research methods

  • Randomized controlled trials

Collaboration

  • Karolinska Institutet, Stockholm, Sweden
  • Kuopio University Hospital, the Finnish Medicines Agency, National Institute for Health and Welfare, the Helsinki Deaconess Institute, Finland
  • St. Petersburg Bekhterev Psychoneurological Research Institute, Valdman Institute of Pharmacology, Pavlov State Medical University, Russia
  • University of Auckland, New Zealand

Selected publications

• Tiihonen J, Kuoppasalmi K, Föhr J, Tuomola P, Kuikanmäki O, Vorma H, Sokero P, Haukka J, Meririnne E: A comparison of aripiprazole, methylphenidate and placebo for amphetamine dependence. Am J Psychiatry 2007;164:160-162, 2007.

• Tiihonen J, Krupitsky E, Verbitskaya E, Blokhina E, Mamontova O, Föhr J, Tuomola P, Kuoppasalmi K, Kiviniemi V, Zwartau E: Naltrexone implant for the treatment of polydrug dependence. Am J Psychiatry 2012;169(5):531-6.

• Miles SW, Sheridan J, Russell B, Kydd R, Wheeler A, Walters C, Gamble G, Hardley P, Jensen M, Kuoppasalmi K, Tuomola P, Föhr J, Kuikanmäki O, Vorma H, Salokangas R, Mikkonen A, Kallio M, Kauhanen J, Kiviniemi V, Tiihonen J: Extended release methylphenidate for treatment of amphetamine/methamphetamine dependence: a randomised, double-blind, placebo controlled trial. Addiction 2013;108(7):1279-86.

Keywords

Group members - UEF