Jarkko Rautio
Deputy Head of Department
Professor
Professor of Pharmaceutical Chemistry, vice-head of the School of Pharmacy and director of the Do...
School of Pharmacy, Faculty of Health Sciences
[email protected] | +358 40 353 2791
My research is focused on the chemistry-based methods, especially prodrugs, in drug delivery and targeting. Much of the research is currently focusing on exploiting the body’s natural mechanisms for transporting nutrients, the LAT1 and GLUT1 proteins, for targeted drug delivery across the blood-brain barrier (BBB) and cancer cells that express these transporters.
Research groups
Publications
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Biological evaluation of a glucose‐based boron carrier as a potential agent for boron neutron capture therapy
Imlimthan, Surachet; Bahrami, Katayun; Pehkonen, Henna; Centanni, Alessia; Montaser, Ahmed B; Värä, Arina; Matović, Jelena; Liljenbäck, Heidi; Auchynnikava, Tatsiana; Huttunen, Kristiina M; Roivainen, Anne; Airaksinen, Anu J; Ekholm, Filip S; Monni, Outi; Rautio, Jarkko; Sarparanta, Mirkka, 2025, International journal of cancer, 157, 11, 2374-2384. A1 Journal article (refereed), original research -
Farmaseuttisen kemian perusteet
Rautio, Jarkko; Laine, Krista; Jarho, Pekka; Wallén, Erik; Poso, Antti; Saarinen, Jukka; Auriola, Seppo; Vuorensola, Katariina; Wikberg, Tom; Lindake, Björn, 2025, Farmasian opiskelijayhdistys Fortis ry. D5 Textbook, professional manual or guide -
Green techniques to develop food-grade Resveratrol Eudraguard® Biotic/Control microparticles as a shield against stress conditions
Lombardo, Rosamaria; Rizzo, Salvatore; Rautio, Jarkko; Pignatello, Rosario, 2025, Journal of drug delivery science and technology, 112, 107286. A1 Journal article (refereed), original research -
Protective Role and Enhanced Intracellular Uptake of Curcumin in Retinal Cells Using Self-Emulsifying Drug Delivery Systems (SNEDDS)
Zingale, Elide; Masuzzo, Sebastiano; Lajunen, Tatu; Reinisalo, Mika; Rautio, Jarkko; Consoli, Valeria; D’Amico, Agata Grazia; Vanella, Luca; Pignatello, Rosario, 2025, Pharmaceuticals, 18, 2, 265. A1 Journal article (refereed), original research -
Synthesis, In vitro Characterization and Biopharmaceutical Evaluation of a Novel Phosphate Prodrug of Sorafenib
Dinh, Simon Hoang; Fisker, Christian Ding; Järvinen, Juulia; Vellonen, Kati-Sisko; Bauer-Brandl, Annette; Nielsen, Poul; Rautio, Jarkko; Brandl, Martin, 2025, European journal of pharmaceutical sciences, 217, 107397. A1 Journal article (refereed), original research -
Unraveled cancer cell survival-associated amino acid metabolism of HepG2 cells altered by Thai rat-tailed radish microgreen extract examined by untargeted LC-MS/MS analysis
Kaimuangpak, Karnchanok; Lehtonen, Marko; Rautio, Jarkko; Weerapreeyakul, Natthida, 2025, Food chemistry, 474, 143206. A1 Journal article (refereed), original research -
A technological comparison of freeze-dried poly-ɛ-caprolactone (PCL) and poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with clozapine for nose-to-brain delivery
Lombardo, Rosamaria; Ruponen, Marika; Rautio, Jarkko; Lampinen, Riikka; Kanninen, Katja M.; Koivisto, Anne M.; Penttilä, Elina; Löppönen, Heikki; Demartis, Sara; Giunchedi, Paolo; Rassu, Giovanna; Fragalà, Maria Elena; Pignatello, Rosario, 2024, Journal of drug delivery science and technology, 93, 105419. A1 Journal article (refereed), original research -
Asymmetric Synthesis and Biological Evaluation of Both Enantiomers of 5- and 6-Boronotryptophan as Potential Boron Delivery Agents for Boron Neutron Capture Therapy
Retini, Michele; Järvinen, Juulia; Bahrami, Katayun; Tampio, Janne; Bartoccini, Francesca; Riihelä, Petri; Pehkonen, Henna; Värä, Arina; Laitinen, Tuomo; Huttunen, Kristiina M.; Rautio, Jarkko; Piersanti, Giovanni; Timonen, Juri M, 2024, Acs medicinal chemistry letters, 15, 12, 2121-2128. A1 Journal article (refereed), original research -
Formulating Resveratrol and Melatonin Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Ocular Administration Using Design of Experiments
Zingale, Elide; Bonaccorso, Angela; D’Amico, Agata Grazia; Lombardo, Rosamaria; D’Agata, Velia; Rautio, Jarkko; Pignatello, Rosario, 2024, Pharmaceutics, 16, 1, 125. A1 Journal article (refereed), original research -
Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates
Subbaiah, Murugaiah A M; Rautio, Jarkko; Meanwell, Nicholas A, 2024, Chemical society reviews, 53, 4, 2099-2210. A2 Review article, Literature review, Systematic review

