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Kati-Sisko Vellonen

Kati-Sisko Vellonen

University Teacher

School of Pharmacy, Faculty of Health Sciences

[email protected] | +358 50 410 7315

Information Publications

Research groups

Ocular Drug Delivery group (ODD) 01.01.2010 -

Keywords

drug transport mass spectrometry ocular pharmacokinetics pharmacokinetic modelling

Publications

51/51 items

Exploring the effect of intracellular loop 1 genetic variants in human ABCG2 on transport activity and protein abundance
Sjöstedt, Noora; Timmermans, Ritchie GM; Vieraankivi, Marika; Suominen, Laura; Vellonen, Kati-Sisko; Bhattacharya, Madhushree; Auriola, Seppo; Kidron, Heidi, 2025, Drug metabolism and pharmacokinetics, 62, 101482. A1 Journal article (refereed), original research
In Vitro Characterization of SLCO2B1 Genetic Variants
Sinokki, Alli; Miinalainen, Annika; Kivioja, Saara; Kiander, Wilma; Vellonen, Kati-Sisko; Bhattacharya, Madhushree; Gynther, Mikko; Huttunen, Kristiina M; Auriola, Seppo; Niemi, Mikko; Kidron, Heidi, 2025, Journal of pharmaceutical sciences, 114, 6, 103772. A1 Journal article (refereed), original research
Intravitreal Sustained Release of Dexamethasone from a Self-Healing Injectable Hydrogel: An In Vivo Safety and Release Study
Annala, Ada; Sadeghi, Amir; Toropainen, Elisa; Valtari, Annika; Puranen, Jooseppi; Paterno, Jussi J; Pirskanen, Lea; Vellonen, Kati-Sisko; Hennink, Wim E; Ruponen, Marika; Vermonden, Tina; Urtti, Arto, 2025, Molecular pharmaceutics, [Online ahead of print September 30, 2025], 1-12. A1 Journal article (refereed), original research
Melanin-Binding-Based Discovery of Topically Instilled Carbonic Anhydrase Inhibitors for Targeted Delivery and Prolonged Action in the Eye
Valtari, Annika; Kalinin, Stanislav; Jäntti, Janika; Vanhanen, Pekka; Martina, Hanzlikova; Arun, Tonduru; Katja, Stenberg; Tapani, Viitala; Vellonen, Kati-Sisko; Toropainen, Elisa; Ruponen, Marika; Urtti, Arto, 2025, Molecular pharmaceutics, 22, 2, 721-732. A1 Journal article (refereed), original research
Thermoresponsive Hydrogels with Tunable Viscoelasticity for Extended Ocular Drug Delivery
Pilipenko, Iuliia; Sorsa, Teemu; Valtari, Annika; Posio, Susanna; Vellonen, Kati-Sisko; Subrizi, Astrid; Hietala, Sami; Ruponen, Marika; Urtti, Arto, 2025, Biomacromolecules, 26, 6, 3721-3731. A1 Journal article (refereed), original research
Barcode lipids for absolute quantitation of liposomes in ocular tissues
Merivaara, Arto; Puranen, Jooseppi; Sadeghi, Amir; Zashikhina, Natalia; Pirskanen, Lea; Lajunen, Tatu; Terasaki, Tetsuya; Auriola, Seppo; Vellonen, Kati Sisko; Urtti, Arto, 2024, Journal of controlled release, 370, 1-13. A1 Journal article (refereed), original research
Comprehensive ocular and systemic pharmacokinetics of dexamethasone after subconjunctival and intravenous injections in rabbits
Valtari, Annika; Posio, Susanna; Toropainen, Elisa; Balla, Anusha; Puranen, Jooseppi; Sadeghi, Amir; Ruponen, Marika; Ranta, Veli-Pekka; Vellonen, Kati-Sisko; Urtti, Arto; del Amo, Eva M, 2024, European journal of pharmaceutics and biopharmaceutics, 198, 114260. A1 Journal article (refereed), original research
Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues
Hammid, Anam; Fallon, John K; Vellonen, Kati Sisko; Lassila, Toni; Reinisalo, Mika; Urtti, Arto; Gonzalez, Francisco; Tolonen, Ari; Smith, Philip C; Honkakoski, Paavo, 2023, European journal of pharmaceutical sciences, 191, 106603. A1 Journal article (refereed), original research
Altering distribution profile of palbociclib by its prodrugs
Järvinen, Juulia; Montaser, Ahmed B; Adla, Santosh Kumar; Leppänen, Jukka; Lehtonen, Marko; Vellonen, Kati-Sisko; Laitinen, Tuomo; Jalkanen, Aaro; Elmquist, William F; Timonen, Juri; Huttunen, Kristiina M; Rautio, Jarkko, 2023, European journal of pharmaceutical sciences, 2024; 192, 106637. A1 Journal article (refereed), original research
Comparison of barrier properties of outer blood-retinal barrier models - Human stem cell-based models as a novel tool for ocular drug discovery
Hellinen, Laura; Hongisto, Heidi; Ramsay, Eva; Kaarniranta, Kai; Vellonen, Kati-Sisko; Skottman, Heli; Ruponen, Marika, 2023, European journal of pharmaceutics and biopharmaceutics, 184, 181-188. A1 Journal article (refereed), original research
Functional Characterization of Six SLCO1B1 (OATP1B1) Variants Observed in Finnish Individuals with a Psychotic Disorder
Häkkinen, Katja; Kiander, Wilma; Kidron, Heidi; Lähteenvuo, Markku; Urpa, Lea; Lintunen, Jonne; Vellonen, Kati Sisko; Auriola, Seppo; Holm, Minna; Lahdensuo, Kaisla; Kampman, Olli; Isometsä, Erkki; Kieseppä, Tuula; Lönnqvist, Jouko; Suvisaari, Jaana; Hietala, Jarmo; Tiihonen, Jari; Palotie, Aarno; Ahola-Olli, Ari V.; Niemi, Mikko, 2023, Molecular pharmaceutics, 20, 3, 1500-1508. A1 Journal article (refereed), original research
In vitro identification of decreased function phenotype ABCG2 variants
Suominen, Laura; Sjöstedt, Noora; Vellonen, Kati-Sisko; Gynther, Mikko; Auriola, Seppo; Kidron, Heidi, 2023, European journal of pharmaceutical sciences, 188, 106527. A1 Journal article (refereed), original research
Mass spectrometry in ocular drug research
del Amo, Eva M.; Vellonen, Kati‐Sisko; Urtti, Arto; Terasaki, Tetsuya; Hammid, Anam; Honkakoski, Paavo; Auriola, Seppo, 2023, Mass spectrometry reviews, [First published: 02 August 2023], 1-32. A2 Review article, Literature review, Systematic review
A Novel Ferroptosis Inhibitor UAMC-3203, a Potential Treatment for Corneal Epithelial Wound
Balla, Anusha; Tran, Bao; Valtari, Annika; Steven, Philipp; Scarpellini, Camilla; Augustyns, Koen; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika, 2022, Pharmaceutics, 2023; 15, 1, 118. A1 Journal article (refereed), original research
Functional in vitro characterization of SLCO1B1 variants and simulation of the clinical pharmacokinetic impact of impaired OATP1B1 function.
Wilma, Kiander; Noora, Sjöstedt; Riikka, Manninen; Liina, Jaakkonen; Kati-Sisko, Vellonen; Mikko, Neuvonen; Mikko, Niemi; Seppo, Auriola; Heidi, Kidron, 2022, European journal of pharmaceutical sciences, 176, 106246. A1 Journal article (refereed), original research
Retraction: Hellinen et al. Drug Flux across RPE Cell Models: The Hunt for an Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery. Pharmaceutics 2020, 12, 176
Hellinen, Laura; Hongisto, Heidi; Ramsay, Eva; Kaarniranta, Kai; Vellonen, Kati-Sisko; Skottman, Heli; Ruponen, Marika, 2022, Pharmaceutics, 14, 3, 595. B1 Non-refereed journal articles
Understanding dexamethasone kinetics in the rabbit tear fluid: Drug release and clearance from solution, suspension and hydrogel formulations
Balla, Anusha; Ruponen, Marika; Valtari, Annika; Toropainen, Elisa; Tuomainen, Marjo; Alvarez-Lorenzo, Carmen; del Amo, Eva M.; Urtti, Arto; Vellonen, Kati-Sisko, 2022, European journal of pharmaceutics and biopharmaceutics, 172, 53-60. A1 Journal article (refereed), original research
Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin
Toropainen, Elisa; Fraser-Miller, Sara J; Novakovic, Dunja; Del Amo, Eva M; Vellonen, Kati-Sisko; Ruponen, Marika; Viitala, Tapani; Korhonen, Ossi; Auriola, Seppo; Hellinen, Laura; Reinisalo, Mika; Tengvall, Unni; Choi, Stephanie; Absar, Mohammad; Strachan, Clare; Urtti, Arto, 2021, Pharmaceutics, 13, 4, 452. A1 Journal article (refereed), original research
Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye
Fayyaz, Anam; Vellonen, Kati-Sisko; Ranta, Veli-Pekka; Toropainen, Elisa; Reinisalo, Mika; Valtari, Annika; Puranen, Jooseppi; D'Amico Ricci, Giuseppe; Heikkinen, Emma M.; Gardner, Iain; Ruponen, Marika; Urtti, Arto; Jamei, Masoud; del Amo, Eva M, 2021, European journal of pharmaceutics and biopharmaceutics, 166, 155-162. A1 Journal article (refereed), original research
Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues
Balla, Anusha; Auriola, Seppo; Grey, Angus C; Demarais, Nicholas J; Valtari, Annika; Heikkinen, Emma M; Toropainen, Elisa; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika, 2021, Pharmaceutics, 13, 5, 658. A1 Journal article (refereed), original research
The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality
Kiander, Wilma; Vellonen, Kati-Sisko; Malinen, Melina M.; Gynther, Mikko; Hagström, Marja; Bhattacharya, Madhushree; Auriola, Seppo; Koenderink, Jan B.; Kidron, Heidi, 2021, Pharmaceutical research, 38, 10, 1663-1675. A1 Journal article (refereed), original research
Drug Flux Across RPE Cell Models: The Hunt for An Appropriate Outer Blood-Retinal Barrier Model for Use in Early Drug Discovery
Hellinen, Laura; Hongisto, Heidi; Ramsay, Eva; Kaarniranta, Kai; Vellonen, Kati-Sisko; Skottman, Heli; Ruponen, Marika, 2020, Pharmaceutics, 12, 2, 176. A1 Journal article (refereed), original research
Prodrug Approach for Posterior Eye Drug Delivery: Synthesis of Novel Ganciclovir Prodrugs and in Vitro Screening with Cassette Dosing
Heikkinen, Emma M; Ruponen, Marika; Jasper, Lisa-Marie; Leppänen, Jukka; Hellinen, Laura; Urtti, Arto; Auriola, Seppo; Rautio, Jarkko; Vellonen, Kati-Sisko, 2020, Molecular pharmaceutics, 17, 6, 1945-1953. A1 Journal article (refereed), original research
The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy
Kilpeläinen, Tommi P; Hellinen, Laura; Vrijdag, Johannes; Yan, Xu; Svarcbahs, Reinis; Vellonen, Kati-Sisko; Lambeir, Anne-Marie; Huttunen, Henri; Urtti, Arto; Wallen, Erik; Myöhänen, Timo, 2020, Biomedicine and pharmacotherapy, 128, 110253. A1 Journal article (refereed), original research
Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits
Fayyaz, Anam; Ranta, Veli-Pekka; Toropainen, Elisa; Vellonen, Kati-Sisko; Valtari, Annika; Puranen, Jooseppi; Ruponen, Marika; Gardner, Iain; Urtti, Arto; Jamei, Masoud; del Amo, Eva M., 2020, European journal of pharmaceutical sciences, 155, 105553. A1 Journal article (refereed), original research
Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics
Heikkinen, EM; Auriola, S; Ranta, VP; Demarais, N; Grey, A; Del Amo, E; Toropainen, E; Vellonen, KS; Urtti, A; Ruponen, M, 2019, Molecular pharmaceutics, 16, 9, 3968-3976. A1 Journal article (refereed), original research
Intravitreal Pharmacokinetics in Mice: SPECT/CT Imaging and Scaling to Rabbits and Humans
Schmitt, Mechthild; Hippeläinen, Eero; Raviña, Manuela; Arango-Gonzalez, Blanca; Antopolsky, Maxim; Vellonen, Kati-Sisko; Airaksinen, Anu J; Urtti, Arto, 2019, Molecular pharmaceutics, 16, 10, 4399-4404. A1 Journal article (refereed), original research
L-Type Amino Acid Transporter 1 (LAT1)-Utilizing Prodrugs Are Carrier-Selective Despite Having Low Affinity for Organic Anion Transporting Polypeptides (OATPs)
Huttunen, Johanna; Gynther, Mikko; Vellonen, KatiSisko; Huttunen, Kristiina M, 2019, International journal of pharmaceutics, 571, 118714. A1 Journal article (refereed), original research
L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia
Huttunen J, Peltokangas S, Gynther M, Natunen T, Hiltunen M, Auriola S, Ruponen M, Vellonen KS, Huttunen KM, 2019, Scientific reports, 9, 12860. A1 Journal article (refereed), original research
Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits
Fayyaz, A; Ranta, VP; Toropainen, E; Vellonen, KS; Ricci, GD; Reinisalo, M; Heikkinen, EM; Gardner, I; Urtti, A; Jamei, M; del Amo, EM, 2019, Molecular pharmaceutics, 12, 4, e007045. A1 Journal article (refereed), original research
Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation
Ramsay, E; Hagström, M; Vellonen, KS; Boman, S; Toropainen, E; Del Amo, EM; Kidron, H; Urtti, A; Ruponen, M, 2019, European journal of pharmaceutics and biopharmaceutics, 143, 18-23. A1 Journal article (refereed), original research
Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes
Gynther, Mikko; Puris, Elena; Peltokangas, Soile; Auriola, Seppo; Kanninen, Katja M; Koistinaho, Jari; Huttunen, Kristiina M; Ruponen, Marika; Vellonen, Kati-Sisko, 2018, Pharmaceutical research, 2019; 36, 17. A1 Journal article (refereed), original research
Esterase activity in porcine and albino rabbit ocular tissues
Heikkinen, Emma M; del Amo, Eva M; Ranta, Veli-Pekka; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika, 2018, European journal of pharmaceutical sciences, 123, 106-110. A1 Journal article (refereed), original research
Expression, activity and pharmacokinetic impact of ocular transporters
Vellonen, Kati-Sisko; Hellinen, Laura; Mannermaa, Eliisa; Ruponen, Marika; Urtti, Arto; Kidron, Heidi, 2018, Advanced drug delivery reviews, 126, 3-22. A2 Review article, Literature review, Systematic review
Iho lääkeaineiden antoreittinä
Urtti, Arto; Ruponen, Marika; Pajula, Katja; Vellonen, Kati-Sisko, 2018, Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo, Biofarmasian perusteet, 135-148. D2 Article in a professional book (incl. an introduction by the editor)
Keuhkot lääkeaineen antoreittinä
Ruponen, Marika; Pajula, Katja; Mönkkönen, Jukka; Vellonen, Kati-Sisko, 2018, Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo, Biofarmasian perusteet, 121-134. D2 Article in a professional book (incl. an introduction by the editor)
Suun kautta otettujen lääkeaineiden imeytyminen
Urtti, Arto; Ruponen, Marika; Pajula, Katja; Yliperttula, Marjo; Honkakoski, Paavo; Ranta, Veli-Pekka; Kidron, Heidi; Vellonen, Kati-Sisko, 2018, Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo, Biofarmasian perusteet, 57-96. D2 Article in a professional book (incl. an introduction by the editor)
Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease
Vellonen KS, Ihalainen J, Boucau M-C, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M, 2017, Pharmaceutical research, 34, 12, 2652-2662. A1 Journal article (refereed), original research
Farmakokinetiikan perusteet
Ranta Veli-Pekka, Honkakoski Paavo, Ruponen Marika, Vellonen Kati-Sisko, 2017, Farmasian opiskelijayhdistys Fortis ry. D5 Textbook, professional manual or guide
Pharmacokinetic aspects of retinal drug delivery
del Amo Eva M, Rimpelä Anna-Kaisa, Heikkinen Emma, Kari Otto K, Ramsay Eva, Lajunen Tatu, Schmitt Mechthild, Pelkonen Laura, Bhattacharya Madhushree, Richardson Dominique, Subrizi Astrid, Turunen Tiina, Reinisalo Mika, Itkonen Jaakko, Toropainen Elisa, Casteleijn Marco, Kidron Heidi, Antopolsky Maxim, Vellonen Kati-Sisko, Ruponen Marika, et al., 2017, Progress in retinal and eye research, 57, 134-185. A2 Review article, Literature review, Systematic review
Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity
Küblbeck Jenni, Hakkarainen Jenni J, Petsalo Aleksanteri, Vellonen Kati-Sisko, Tolonen Ari, Reponen Petri, Forsberg Markus M, Honkakoski Paavo, 2016, Journal of pharmaceutical sciences, 105, 2, 941-949. A1 Journal article (refereed), original research
Human corneal cell culture models for drug toxicity studies
Rönkkö Seppo, Vellonen Kati-Sisko, Järvinen Kristiina, Toropainen Elisa, Urtti Arto, 2016, Drug delivery and translational research, 6, 6, 660-675. A2 Review article, Literature review, Systematic review
Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling
Soininen Suvi K, Vellonen Kati-Sisko, Heikkinen Aki T, Auriola Seppo, Ranta Veli-Pekka, Urtti Arto, Ruponen Marika, 2016, Molecular pharmaceutics, 13, 4, 1358-1365. A1 Journal article (refereed), original research
Intravitreal clearance and volume of distribution of compounds in rabbits: In silico prediction and pharmacokinetic simulations for drug development
Del Amo Eva M, Vellonen Kati-Sisko, Kidron Heidi, Urtti Arto, 2015, European journal of pharmaceutics and biopharmaceutics, 95, 215-226. A1 Journal article (refereed), original research
Prediction of ocular drug distribution from systemic blood circulation
Vellonen Kati-Sisko, Soini Esa-Matti, del Amo Eva M, Urtti Arto, 2015, Molecular pharmaceutics, 13 (2016), 9, 2906-2911. A1 Journal article (refereed), original research
A critical assessment of in vitro tissue models for ADME and drug delivery
Vellonen Kati-Sisko, Malinen Melina, Mannermaa Eliisa, Subrizi Astrid, Toropainen Elisa, Lou Yan-Ru, Kidron Heidi, Yliperttula Marjo, Urtti Arto, 2014, Journal of controlled release, 190, 94-114. A2 Review article, Literature review, Systematic review
Challenges of using in vitro data for modeling p-glycoprotein efflux in the blood-brain barrier
Sjöstedt Noora, Kortejärvi Hanna, Kidron Heidi, Vellonen Kati-Sisko, Urtti Arto, Yliperttula Marjo, 2013, Pharmaceutical research, 2014:31, 1-19. A2 Review article, Literature review, Systematic review
Prediction of the vitreal half-life of small molecular drug-like compounds
Kidron, Heidi; del Amo, Eva M; Vellonen, Kati-Sisko; Urtti, Arto, 2012, Pharmaceutical research, 29, 3302-3311. A1 Journal article (refereed), original research
Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity
Vellonen K-S, Honkakoski P, Urtti A, 2004, European journal of pharmaceutical sciences, 23, 181-188. A1 Journal article (refereed), original research
Ocular pharmacokinetic modeling using corneal absorption and desorption rates from in vitro permeation experiments with cultured corneal epithelial cells
Ranta V-P, Laavola M, Toropainen E, Vellonen K-S, Talvitie A, Urtti A, 2003, Pharmaceutical research, 20, 9, 1409-1416. A1 Journal article (refereed), original research
Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model
Toropainen E, Ranta V-P, Vellonen K-S, Palmgrén J, Talvitie A, Laavola M, Suhonen P, Hämäläinen KM, Auriola S, Urtti A, 2003, European journal of pharmaceutical sciences, 20, 99-106. A1 Journal article (refereed), original research

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Kati-Sisko Vellonen

Research groups

Keywords

Exploring the effect of intracellular loop 1 genetic variants in human ABCG2 on transport activity and protein abundance

In Vitro Characterization of SLCO2B1 Genetic Variants

Intravitreal Sustained Release of Dexamethasone from a Self-Healing Injectable Hydrogel: An In Vivo Safety and Release Study

Melanin-Binding-Based Discovery of Topically Instilled Carbonic Anhydrase Inhibitors for Targeted Delivery and Prolonged Action in the Eye

Thermoresponsive Hydrogels with Tunable Viscoelasticity for Extended Ocular Drug Delivery

Barcode lipids for absolute quantitation of liposomes in ocular tissues

Comprehensive ocular and systemic pharmacokinetics of dexamethasone after subconjunctival and intravenous injections in rabbits

Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues

Altering distribution profile of palbociclib by its prodrugs

Comparison of barrier properties of outer blood-retinal barrier models - Human stem cell-based models as a novel tool for ocular drug discovery

Functional Characterization of Six SLCO1B1 (OATP1B1) Variants Observed in Finnish Individuals with a Psychotic Disorder

In vitro identification of decreased function phenotype ABCG2 variants

Mass spectrometry in ocular drug research

A Novel Ferroptosis Inhibitor UAMC-3203, a Potential Treatment for Corneal Epithelial Wound

Functional in vitro characterization of SLCO1B1 variants and simulation of the clinical pharmacokinetic impact of impaired OATP1B1 function.

Retraction: Hellinen et al. Drug Flux across RPE Cell Models: The Hunt for an Appropriate Outer Blood–Retinal Barrier Model for Use in Early Drug Discovery. Pharmaceutics 2020, 12, 176

Understanding dexamethasone kinetics in the rabbit tear fluid: Drug release and clearance from solution, suspension and hydrogel formulations

Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye

Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues

The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality

Drug Flux Across RPE Cell Models: The Hunt for An Appropriate Outer Blood-Retinal Barrier Model for Use in Early Drug Discovery

Prodrug Approach for Posterior Eye Drug Delivery: Synthesis of Novel Ganciclovir Prodrugs and in Vitro Screening with Cassette Dosing

The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy

Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits

Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics

Intravitreal Pharmacokinetics in Mice: SPECT/CT Imaging and Scaling to Rabbits and Humans

L-Type Amino Acid Transporter 1 (LAT1)-Utilizing Prodrugs Are Carrier-Selective Despite Having Low Affinity for Organic Anion Transporting Polypeptides (OATPs)

L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia

Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits

Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation

Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes

Esterase activity in porcine and albino rabbit ocular tissues

Expression, activity and pharmacokinetic impact of ocular transporters

Iho lääkeaineiden antoreittinä

Keuhkot lääkeaineen antoreittinä

Suun kautta otettujen lääkeaineiden imeytyminen

Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease

Farmakokinetiikan perusteet

Pharmacokinetic aspects of retinal drug delivery

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity

Human corneal cell culture models for drug toxicity studies

Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling

Intravitreal clearance and volume of distribution of compounds in rabbits: In silico prediction and pharmacokinetic simulations for drug development

Prediction of ocular drug distribution from systemic blood circulation

A critical assessment of in vitro tissue models for ADME and drug delivery

Challenges of using in vitro data for modeling p-glycoprotein efflux in the blood-brain barrier

Prediction of the vitreal half-life of small molecular drug-like compounds

Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity

Ocular pharmacokinetic modeling using corneal absorption and desorption rates from in vitro permeation experiments with cultured corneal epithelial cells

Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model