Ahmed Montaser

Specific Transport of Temozolomide Does Not Override DNA Repair-mediated Chemoresistance

Bahrami, Katayan; Kärkkäinen, Jussi; Bibi, Sania; Huttunen, Johanna; Tampio, Janne; Montaser, Ahmed B.; Moody, Catherine L; Lehtonen, Marko; Rautio, Jarkko; Wheelhouse, Richard T; Huttunen, Kristiina M. 2024. European journal of pharmaceutical sciences. 195:

Altering distribution profile of palbociclib by its prodrugs

Järvinen, Juulia; Montaser, Ahmed B; Adla, Santosh Kumar; Leppänen, Jukka; Lehtonen, Marko; Vellonen, Kati-Sisko; Laitinen, Tuomo; Jalkanen, Aaro; Elmquist, William F; Timonen, Juri; Huttunen, Kristiina M; Rautio, Jarkko. 2023. European journal of pharmaceutical sciences. 2024; 192:

Amino acid derivative of probenecid potentiates apoptosis-inducing effects of vinblastine by increasing oxidative stress in a cancer cell-specific manner

Huttunen, Johanna; Tampio, Janne; Järvinen, Juulia; Montaser, Ahmed B; Markowicz-Piasecka, Magdalena; Huttunen, Kristiina M. 2023. Chemico-biological interactions. 2024; 388:

Combating Neuroinflammation By Improving Intracellular Brain Drug Delivery - Focus On L-Type Amino Acid Transporter 1

Montaser, Ahmed. 2023. Publications of the University of Eastern Finland. Dissertations in Health Sciences

Sodium-Dependent Neutral Amino Acid Transporter 2 Can Serve as a Tertiary Carrier for l -Type Amino Acid Transporter 1-Utilizing Prodrugs

Huttunen, Johanna; Kronenberger, Thales; Montaser, Ahmed B.; Králová, Adéla; Terasaki, Tetsuya; Poso, Antti; Huttunen, Kristiina M.. 2023. Molecular pharmaceutics. 20: 1331-1346

Targeting Glial Cells by Organic Anion-Transporting Polypeptide 1C1 (OATP1C1)-Utilizing l-Thyroxine-Derived Prodrugs

Tonduru, Arun Kumar; Maljaei, Seyed Hamed; Adla, Santosh Kumar; Anamea, Landry; Tampio, Janne; Králová, Adéla; Jalkanen, Aaro J; Espada, Catarina; Santos, Inês Falcato; Montaser, Ahmed B; Rautio, Jarkko; Kronenberger, Thales; Poso, Antti; Huttunen, Kristiina M. 2023. Journal of medicinal chemistry. 66: 15094-15114

Aminopeptidase B can bioconvert L-type amino acid transporter 1 (LAT1)-utilizing amide prodrugs in the brain

Hugele, Agathe; Löffler, Susanne; Molina, Belén Hernández; Guillon, Melina; Montaser, Ahmed B.; Auriola, Seppo; Huttunen, Kristiina M.. 2022. Frontiers in pharmacology. 13: . 1034964

Comparison of Experimental Strategies to Study l-Type Amino Acid Transporter 1 (LAT1) Utilization by Ligands

Huttunen, Johanna; Agami, Mahmoud; Tampio, Janne; Montaser, Ahmed B; Huttunen, Kristiina M. 2022. Molecules. 27:

Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice

Montaser, Ahmed B.; Kuiri, Janita; Natunen, Teemu; Hruška, Pavel; Potěšil, David; Auriola, Seppo; Hiltunen, Mikko; Terasaki, Tetsuya; Lehtonen, Marko; Jalkanen, Aaro; Huttunen, Kristiina M. 2022. Life sciences. 310:

L-type Amino Acid Transporter 1 Utilizing Ferulic Acid Derivatives Show Increased Drug Delivery in the Mouse Pancreas Along with Decreased Lipid Peroxidation and Prostaglandin Production

Tampio, Janne; Markowicz-Piasecka, Magdalena; Montaser, Ahmed; Rysä, Jaana; Kauppinen, Anu; Huttunen, Kristiina M. 2022. Molecular pharmaceutics. 19: 380-3819

Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery

Huttunen, Kristiina M.; Terasaki, Tetsuya; Urtti, Arto; Montaser, Ahmed B.; Uchida, Yasuo. 2022. Pharmaceutical research. 39: 1363-1392

Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)

Markowicz-Piasecka, M; Huttunen, J; Montaser, A; Adla, SK; Auriola, S; Lehtonen, M; Huttunen, KM. 2021. International journal of molecular sciences. 22: 7727

Molecular characteristics supporting L-Type amino acid transporter 1 (LAT1)-mediated translocation

Kärkkäinen, Jussi; Laitinen, Tuomo; Markowicz-Piasecka, Magdalena; Montaser, Ahmed; Lehtonen, Marko; Rautio, Jarkko; Gynther, Mikko; Poso, Antti; Huttunen, Kristiina M. 2021. Bioorganic chemistry. 112: 104921

Exploring the Biochemical Foundations of a Successful GLUT1-Targeting Strategy to BNCT: Chemical Synthesis and In Vitro Evaluation of the Entire Positional Isomer Library of ortho-Carboranylmethyl-Bearing Glucoconjugates

Matovic, Jelena; Järvinen, Juulia; Sokka, Iris K; Imlimthan, Surachet; Raitanen, Jan-Erik; Montaser, Ahmed; Maaheimo, Hannu; Huttunen, Kristiina M; Peräniemi, Sirpa; Airaksinen, Anu J; Sarparanta, Mirkka; Johansson, Mikael P; Rautio, Jarkko; Ekholm, Filip S. 2020. Molecular pharmaceutics. 2021; 18: 285-304

Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis

Markowicz-Piasecka, Magdalena; Huttunen, Johanna; Montaser, Ahmed; Huttunen, Kristiina. 2020. Apoptosis. 26: 426-440

L-Type Amino Acid Transporter 1 (LAT1)-Utilizing Efflux Transporter Inhibitors Can Improve the Brain Uptake and Apoptosis-Inducing Effects of Vinblastine in Cancer Cells

Montaser, Ahmed; Markowicz-Piasecka, Magdalena; Sikora, Joanna; Jalkanen, Aaro; Huttunen, Kristiina M. 2020. International journal of pharmaceutics. 586: 119585

L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells

Montaser, Ahmed B; Järvinen, Juulia; Löffler, Susanne; Huttunen, Johanna; Auriola, Seppo; Lehtonen, Marko; Jalkanen, Aaro; Huttunen, Kristiina M. 2020. Acs chemical neuroscience. 11: 4301-4315

L-Type Amino Acid Transporter 1-Utilizing Prodrugs of Ketoprofen Can Efficiently Reduce Brain Prostaglandin Levels

Montaser, Ahmed; Lehtonen, Marko; Gynther, Mikko; Huttunen, Kristiina. 2020. Pharmaceutics. 12: 344

Targeting of Perforin Inhibitor into the Brain Parenchyma Via a Prodrug Approach Can Decrease Oxidative Stress and Neuroinflammation and Improve Cell Survival

Tampio, Janne; Huttunen, Johanna; Montaser, Ahmed; Huttunen, Kristiina M. 2020. Molecular neurobiology. 57: 4563-4577

Astrocyte-Targeted Transporter-Utilizing Derivatives of Ferulic Acid Can Have Multifunctional Effects Ameliorating Inflammation and Oxidative Stress in the Brain

Montaser, A; Huttunen, J; Ibrahim, SA; Huttunen, KM. 2019. Oxidative medicine and cellular longevity. 2019: 3528148

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Specific Transport of Temozolomide Does Not Override DNA Repair-mediated Chemoresistance

Altering distribution profile of palbociclib by its prodrugs

Amino acid derivative of probenecid potentiates apoptosis-inducing effects of vinblastine by increasing oxidative stress in a cancer cell-specific manner

Combating Neuroinflammation By Improving Intracellular Brain Drug Delivery - Focus On L-Type Amino Acid Transporter 1

Sodium-Dependent Neutral Amino Acid Transporter 2 Can Serve as a Tertiary Carrier for l -Type Amino Acid Transporter 1-Utilizing Prodrugs

Targeting Glial Cells by Organic Anion-Transporting Polypeptide 1C1 (OATP1C1)-Utilizing l-Thyroxine-Derived Prodrugs

Aminopeptidase B can bioconvert L-type amino acid transporter 1 (LAT1)-utilizing amide prodrugs in the brain

Comparison of Experimental Strategies to Study l-Type Amino Acid Transporter 1 (LAT1) Utilization by Ligands

Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice

L-type Amino Acid Transporter 1 Utilizing Ferulic Acid Derivatives Show Increased Drug Delivery in the Mouse Pancreas Along with Decreased Lipid Peroxidation and Prostaglandin Production

Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery

Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)

Molecular characteristics supporting L-Type amino acid transporter 1 (LAT1)-mediated translocation

Exploring the Biochemical Foundations of a Successful GLUT1-Targeting Strategy to BNCT: Chemical Synthesis and In Vitro Evaluation of the Entire Positional Isomer Library of ortho-Carboranylmethyl-Bearing Glucoconjugates

Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis

L-Type Amino Acid Transporter 1 (LAT1)-Utilizing Efflux Transporter Inhibitors Can Improve the Brain Uptake and Apoptosis-Inducing Effects of Vinblastine in Cancer Cells

L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells

L-Type Amino Acid Transporter 1-Utilizing Prodrugs of Ketoprofen Can Efficiently Reduce Brain Prostaglandin Levels

Targeting of Perforin Inhibitor into the Brain Parenchyma Via a Prodrug Approach Can Decrease Oxidative Stress and Neuroinflammation and Improve Cell Survival

Astrocyte-Targeted Transporter-Utilizing Derivatives of Ferulic Acid Can Have Multifunctional Effects Ameliorating Inflammation and Oxidative Stress in the Brain