Annakaisa Haapasalo
Professor
I am Professor and leader of the Molecular Neurodegeneration Research Group at A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland.
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
annakaisa.haapasalo@uef.fi | +358 40 355 2768
I am Professor in Molecular Neurodegeneration and Research Group Leader. My current research interests are: Potential synaptic dysfunction, contribution of microglia and inflammation, and alterations in protein degradation and cellular energy metabolism in the pathogenesis of frontotemporal dementia (FTD) as well as fluid biomarkers in FTD and other early onset dementias. Currently, I also coordinate the EU JPND programme-funded SynaDeg (Pre-diagnostic early synaptic disturbances in neurodegenerative diseases) project. In addition, I am Chair of the Regional Steering Group of the Kuopio Brain & Mind network belonging under the umbrella of Neurocenter Finland.
The aim of our studies is to provide new insights into the molecular basis of genetic (especially C9orf72 repeat expansion-associated) and sporadic frontotemporal dementia (FTD) and translate our findings for the benefit of the patients by discovering novel biomarker or therapeutic candidate targets.
Research groups
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Brain Research Unit (BRU) - Clinical Trial Unit 01.01.2022 -
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Annakaisa Haapasalo Group (Molecular Neurodegener… 01.06.2015 -
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NPH and Early AD 01.01.2010 -
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Finnish FTD Research Network (FinFTD) 01.05.2016 -
Projects
Publications
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Cortico-spinal tDCS in amyotrophic lateral sclerosis: A randomized, double-blind, sham-controlled trial followed by an open-label phase
Benussi, Alberto; Cantoni, Valentina; Grassi, Mario; Libri, Ilenia; Cotelli, Maria Sofia; Tarantino, Barbara; Datta, Abhishek; Thomas, Chris; Huber, Nadine; Kärkkäinen, Sari; Herukka, Sanna-Kaisa; Haapasalo, Annakaisa; Filosto, Massimiliano; Padovani, Alessandro; Borroni, Barbara. 2023. Brain stimulation. 16: 1666-1676 -
Editorial: Molecular mechanisms underlying C9orf72 neurodegeneration, volume II
Gallo, Jean Marc; Nishimura, Agnes; Haapasalo, Annakaisa. 2023. Frontiers in cellular neuroscience. 17: . 1357319 -
Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates
Kemppainen, Susanna; Huber, Nadine; Willman, Roosa-Maria; Zamora, Ana; Makinen, Petra; Martiskainen, Henna; Takalo, Mari; Haapasalo, Annakaisa; Sobrino, Tomas; Gomez, Manuel Antonio Gonzalez; Pineiro, Yolanda; Rivas, Jose; Himmelreich, Uwe; Hiltunen, Mikko. 2023. Cells. 12: -
Psychopharmacological Medication Use in Frontotemporal Dementia at the Time of Diagnosis: Comparison with Alzheimer’s Disease
Katisko, Kasper; Krüger, Johanna; Soppela, Helmi; Hartikainen, Päivi; Haapasalo, Annakaisa; Remes, Anne M.; Solje, Eino. 2023. Journal of Alzheimer's disease. 95: 677-685 -
Rare PMP22 variants in mild to severe neuropathy uncorrelated to plasma GDF15 or neurofilament light
Palu, Edouard; Järvilehto, Julius; Pennonen, Jana; Huber, Nadine; Herukka, Sanna-Kaisa; Haapasalo, Annakaisa; Isohanni, Pirjo; Tyynismaa, Henna; Auranen, Mari; Ylikallio, Emil. 2023. Neurogenetics. 24: 291-301 -
Serum Cathepsin S Levels Do Not Show Alterations in Different Clinical, Neuropathological, or Genetic Subtypes of Frontotemporal Dementia Patients nor in Comparison to Healthy Control Individuals
Heikkinen, Sami; Huber, Nadine; Katisko, Kasper; Kokkola, Tarja; Hartikainen, Päivi; Krüger, Johanna; Leinonen, Ville; Korhonen, Ville E; Herukka, Sanna-Kaisa; Remes, Anne M; Borroni, Barbara; Alberici, Antonella; Libri, Ilenia; Solje, Eino; Haapasalo, Annakaisa. 2023. Journal of Alzheimer's disease. 93: 395-401 -
Traumatic Brain Injury Associates with an Earlier Onset in Sporadic Frontotemporal Dementia
Soppela, Helmi; Krüger, Johanna; Hartikainen, Päivi; Koivisto, Anne; Haapasalo, Annakaisa; Borroni, Barbara; Remes, Anne M.; Katisko, Kasper; Solje, Eino. 2023. Journal of Alzheimer's disease. 91: 225-232 -
Brainstem atrophy is linked to extrapyramidal symptoms in frontotemporal dementia
Heikkinen, Sami; Cajanus, Antti; Katisko, Kasper; Hartikainen, Päivi; Vanninen, Ritva; Haapasalo, Annakaisa; Krüger, Johanna; Remes, Anne M; Solje, Eino. 2022. Journal of neurology. 269: 4488-4497 -
Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers
Jansen, Iris E.; van der Lee, Sven J.; Gomez-Fonseca, Duber; de Rojas, Itziar; Dalmasso, Maria Carolina; Grenier-Boley, Benjamin; Zettergren, Anna; Mishra, Aniket; Ali, Muhammad; Andrade, Victor; Bellenguez, Céline; Kleineidam, Luca; Küçükali, Fahri; Sung, Yun Ju; Tesí, Niccolo; Vromen, Ellen M.; Wightman, Douglas P.; Alcolea, Daniel; Alegret, Montserrat; Alvarez, Ignacio; Amouyel, Philippe; Athanasiu, Lavinia; Bahrami, Shahram; Bailly, Henri; Belbin, Olivia; Bergh, Sverre; Bertram, Lars; Biesse. 2022. Acta neuropathologica. 144: 821-842 -
Modifiable potential risk factors in familial and sporadic frontotemporal dementia
Soppela, Helmi; Katisko, Kasper; Gadola, Yasmine; Krüger, Johanna; Hartikainen, Päivi; Alberici Antonella; Benussi, Alberto; Koivisto,Anne; Haapasalo, Annakaisa; Remes, Anne M; Borroni, Barbara; Solje, Eino. 2022. Annals of clinical and translational neurology. 9: 1195-1205