I am Professor in Molecular Neurodegeneration and Research Group Leader. My current research interests are: Potential synaptic dysfunction, contribution of microglia and inflammation, and alterations in protein degradation and cellular energy metabolism in the pathogenesis of frontotemporal dementia (FTD) as well as fluid biomarkers in FTD and other early onset dementias. Currently, I also coordinate the EU JPND programme-funded SynaDeg (Pre-diagnostic early synaptic disturbances in neurodegenerative diseases) project. In addition, I am Chair of the Regional Steering Group of the Kuopio Brain & Mind network belonging under the umbrella of Neurocenter Finland.
The aim of our studies is to provide new insights into the molecular basis of genetic (especially C9orf72 repeat expansion-associated) and sporadic frontotemporal dementia (FTD) and translate our findings for the benefit of the patients by discovering novel biomarker or therapeutic candidate targets.
Research groups
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Brain Research Unit (BRU) - Clinical Trial Unit
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Annakaisa Haapasalo Group (Molecular Neurodegener… 01.06.2015 -
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NPH and Early AD 01.01.2010 -
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Finnish FTD Research Network (FinFTD) 01.05.2016 -
Projects
Annakaisa Haapasalo appointed as Professor of Molecular Neurodegeneration
https://www.uef.fi/en/article/annakaisa-haapasalo-appointed-as-professor-of-molecular-neurodegeneration
Significant support from Jane and Aatos Erkko Foundation to research on memory disorders
https://www.uef.fi/fi/artikkeli/jane-ja-aatos-erkon-saatiolta-merkittava-tuki-uusille-muistisairauksien-tutkimushankkeille
UEF’s frontotemporal dementia researchers secure prestigious Academy of Finland and EU funding
https://www.uef.fi/en/article/uefs-frontotemporal-dementia-researchers-secure-prestigious-academy-of-finland-and-eu-funding
Publications
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A Small TAT-TrkB Peptide Prevents BDNF Receptor Cleavage and Restores Synaptic Physiology in Alzheimer’s Disease
Fonseca-Gomes, João; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Vaz, Sandra H; Alemãn-Serrano, Nuno; Atalaia-Barbacena, Henrique; Ribeiro-Rodrigues, Leonor; Ramalho, Rita M; Pinto, Rui; Miranda, Hugo Vicente; Tanqueiro, Sara R; de Almeida-Borlido, Carolina; Ramalho, Maria João; Miranda-Lourenço, Catarina; Belo, Rita F; Ferreira, Catarina B; Neves, Vera; Rombo, Diogo M; Viais, Ricardo; Martins, Ivo C; Jerónimo-Santos, André; Caetano, António; Manso, Nuno; Mäkinen, Petra. 2024. Molecular therapy. 32: 3372-3401 A1 Journal article (refereed), original research -
A genome-wide association meta-analysis of all-cause and vascular dementia
Fongang, Bernard; Sargurupremraj, Muralidharan; Jian, Xueqiu; Mishra, Aniket; Damotte, Vincent; de Rojas, Itziar; Skrobot, Olivia; Bis, Joshua C.; Fan, Kang Hsien; Jacobsen, Erin; Li, Gloria Hoi Yee; Yang, Jingyun; Alessandra, Bizzarro; Alessandra, Lauria; Hilal, Saima; Chong, Joyce Ruifen; Chai, Yuek Ling; Knol, M. J.; Concas, Maria Pina; Giorgia, Girotto; Riaz, Moeen; Yu, Chenglong; Guojonsson, Alexander; Lacaze, Paul; Naj, Adam C.; Gireud-Goss, Monica; Wadop, Yannick N.; Soumare, Aicha; Boute. 2024. Alzheimer's & dementia. 20: 5973-5995 A2 Review article, Literature review, Systematic review -
Incidence and Prevalence of Early-Onset Dementia in Finland
Krüger, Johanna; Aaltonen, Mikko; Aho, Kalle; Heikkinen, Sami; Kivisild, Ave; Lehtonen, Adolfina; Leppänen, Laura; Rinnankoski, Iina; Soppela, Helmi; Tervonen, Laura; Suhonen, Noora Maria; Haapasalo, Annakaisa; Portaankorva, Anne M.; Mäki-Petäjä-Leinonen, Anna; Hartikainen, Päivi; Katisko, Kasper; Solje, Eino. 2024. Neurology. 103: A1 Journal article (refereed), original research -
Neurofilamentit keskushermostoa rappeuttavien sairauksien diagnostiikassa
Katisko, Kasper; Haapasalo, Annakaisa; Solje, Eino. 2024. Kliin lab. 41: 12-14 D1 Article in a trade journal -
Cortico-spinal tDCS in amyotrophic lateral sclerosis: A randomized, double-blind, sham-controlled trial followed by an open-label phase
Benussi, Alberto; Cantoni, Valentina; Grassi, Mario; Libri, Ilenia; Cotelli, Maria Sofia; Tarantino, Barbara; Datta, Abhishek; Thomas, Chris; Huber, Nadine; Kärkkäinen, Sari; Herukka, Sanna-Kaisa; Haapasalo, Annakaisa; Filosto, Massimiliano; Padovani, Alessandro; Borroni, Barbara. 2023. Brain stimulation. 16: 1666-1676 A1 Journal article (refereed), original research -
Psychopharmacological Medication Use in Frontotemporal Dementia at the Time of Diagnosis: Comparison with Alzheimer’s Disease
Katisko, Kasper; Krüger, Johanna; Soppela, Helmi; Hartikainen, Päivi; Haapasalo, Annakaisa; Remes, Anne M.; Solje, Eino. 2023. Journal of Alzheimer's disease. 95: 677-685 A1 Journal article (refereed), original research -
Traumatic Brain Injury Associates with an Earlier Onset in Sporadic Frontotemporal Dementia
Soppela, Helmi; Krüger, Johanna; Hartikainen, Päivi; Koivisto, Anne; Haapasalo, Annakaisa; Borroni, Barbara; Remes, Anne M.; Katisko, Kasper; Solje, Eino. 2023. Journal of Alzheimer's disease. 91: 225-232 A1 Journal article (refereed), original research -
Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers
Jansen, Iris E.; van der Lee, Sven J.; Gomez-Fonseca, Duber; de Rojas, Itziar; Dalmasso, Maria Carolina; Grenier-Boley, Benjamin; Zettergren, Anna; Mishra, Aniket; Ali, Muhammad; Andrade, Victor; Bellenguez, Céline; Kleineidam, Luca; Küçükali, Fahri; Sung, Yun Ju; Tesí, Niccolo; Vromen, Ellen M.; Wightman, Douglas P.; Alcolea, Daniel; Alegret, Montserrat; Alvarez, Ignacio; Amouyel, Philippe; Athanasiu, Lavinia; Bahrami, Shahram; Bailly, Henri; Belbin, Olivia; Bergh, Sverre; Bertram, Lars; Biesse. 2022. Acta neuropathologica. 144: 821-842 A1 Journal article (refereed), original research -
Modifiable potential risk factors in familial and sporadic frontotemporal dementia
Soppela, Helmi; Katisko, Kasper; Gadola, Yasmine; Krüger, Johanna; Hartikainen, Päivi; Alberici Antonella; Benussi, Alberto; Koivisto,Anne; Haapasalo, Annakaisa; Remes, Anne M; Borroni, Barbara; Solje, Eino. 2022. Annals of clinical and translational neurology. 9: 1195-1205 A1 Journal article (refereed), original research -
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Bellenguez, Céline; Küçükali, Fahri; Jansen, Iris E.; Kleineidam, Luca; Moreno-Grau, Sonia; Amin, Najaf; Naj, Adam C.; Campos-Martin, Rafael; Grenier-Boley, Benjamin; Andrade, Victor; Holmans, Peter A.; Boland, Anne; Damotte, Vincent; van der Lee, Sven J.; Costa, Marcos R.; Kuulasmaa, Teemu; Yang, Qiong; de Rojas, Itziar; Bis, Joshua C.; Yaqub, Amber; Prokic, Ivana; Chapuis, Julien; Ahmad, Shahzad; Giedraitis, Vilmantas; Aarsland, Dag; Garcia-Gonzalez, Pablo; Abdelnour, Carla; Alarcón-Martín, Em. 2022. Nature genetics. 54: 412-436 A1 Journal article (refereed), original research