Antti Kulkas

Community prevalence of positional obstructive sleep apnea

Duce, Brett L; Kulkas, Antti E; Leppänen, Timo T; Oksenberg, Arie; Töyräs, Juha; Hukins, Craig A, 2025, Journal of clinical sleep medicine, 21, 5, 875–882. A1 Journal article (refereed), original research

Beat-to-beat cardiac repolarization lability increases during hypoxemia and arousals in obstructive sleep apnea patients

Ebrahimian, Serajeddin; Sillanmäki, Saara; Hietakoste, Salla; Kulkas, Antti; Töyräs, Juha; Bailón, Raquel; Hernando, David; Lombardi, Carolina; Grote, Ludger; Bonsignore, Maria R; Saaresranta, Tarja; Pépin, Jean-Louis; Leppänen, Timo; Kainulainen, Samu, 2024, American journal of physiology : heart and circulatory physiology, 326, 5, H1094-H1104. A1 Journal article (refereed), original research

Morbid obesity influences the nocturnal electrocardiogram wave and interval durations among suspected sleep apnea patients

Kainulainen, Samu; Suni, Aaron; Lipponen, Jukka A; Kulkas, Antti; Duce, Brett; Korkalainen, Henri; Nikkonen, Sami; Sillanmäki, Saara, 2023, Annals of noninvasive electrocardiology, 2024; 29, 1, e13101. A1 Journal article (refereed), original research

Obstructive Sleep Apnea Patients With Atrial Arrhythmias Suffer From Prolonged Recovery From Desaturations

Rissanen, Marika; Korkalainen, Henri; Duce, Brett; Sillanmaki, Saara; Pitkanen, Henna; Suni, Aaron; Nikkonen, Sami; Kulkas, Antti; Toyras, Juha; Leppanen, Timo; Kainulainen, Samu, 2023, IEEE transactions on biomedical engineering, 70, 7, 2122-2130. A1 Journal article (refereed), original research

Review and perspective on sleep-disordered breathing research and translation to clinics

Korkalainen, Henri; Kainulainen, Samu; Islind, Anna Sigridur; Óskarsdóttir, María; Strassberger, Christian; Nikkonen, Sami; Töyräs, Juha; Kulkas, Antti; Grote, Ludger; Hedner, Jan; Sund, Reijo; Hrubos-Strom, Harald; Saavedra, Jose M.; Ólafsdóttir, Kristín Anna; Ágústsson, Jón S.; Terrill, Philip I.; McNicholas, Walter T.; Arnardóttir, Erna Sif; Leppänen, Timo, 2023, Sleep medicine reviews, 2024; 73, 101874. A2 Review article, Literature review, Systematic review

Diabetes and cardiovascular diseases are associated with the worsening of intermittent hypoxaemia

Karhu, T; Myllymaa, S; Nikkonen, S; Mazzotti, DR; Kulkas, A; Töyräs, J; Leppänen, T, 2021, Journal of sleep research, 2022; 31, 1, e13441. A1 Journal article (refereed), original research

Comparison of the effect of weight change, simulated computational continuous positive airway pressure treatment and positional therapy on severity of sleep apnea

Kulkas, Antti; Duce, Brett; Töyräs, Juha; Seppä, Juha; Leppänen, Timo, 2020, Journal of sleep research, 2021; 30, 2, e13070. A1 Journal article (refereed), original research

Increased nocturnal arterial pulsation frequencies of obstructive sleep apnoea patients is associated with an increased number of lapses in a psychomotor vigilance task

Kainulainen, Samu; Duce, Brett; Korkalainen, Henri; Leino, Akseli; Huttunen, Riku; Kalevo, Laura; Arnardottir, Erna S; Kulkas, Antti; Myllymaa, Sami; Töyräs, Juha; Leppänen, Timo, 2020, ERJ open research, 6, 4, 00277-202. A1 Journal article (refereed), original research

Longer duration electroencephalogram arousals have a better relationship with impaired vigilance and health status in obstructive sleep apnoea

Duce, Brett; Kulkas, Antti; Töyräs, Juha; Terrill, Philip; Hukins, Craig, 2020, Sleep and breathing, 2021; 25, 1, 263-270. A1 Journal article (refereed), original research

Polysomnographic characteristics of severe obstructive sleep apnea vary significantly between hypertensive and normotensive patients of both genders

Leppänen, T; Kulkas, A; Töyräs, J; Myllymaa, S; Gadoth, N; Oksenberg, A, 2020, Sleep and breathing, 2021; 25, 1, 105-116. A1 Journal article (refereed), original research

Power spectral densities of nocturnal pulse oximetry signals differ in OSA patients with and without daytime sleepiness

Kainulainen, Samu; Töyräs, Juha; Oksenberg, Arie; Korkalainen, Henri; Afara, Isaac O; Leino, Akseli; Kalevo, Laura; Nikkonen, Sami; Gadoth, Natan; Kulkas, Antti; Myllymaa, Sami; Leppänen, Timo, 2020, Sleep medicine, 73, 231-237. A1 Journal article (refereed), original research

Severe Desaturations Increase PVT-based Median Reaction Time and Number of Lapses in OSA Patients

Kainulainen, S; Duce, B; Korkalainen, H; Oksenberg, A; Leino, A; Arnardottir, E; Kulkas, A; Myllymaa, S; Töyräs, J; Leppänen, T, 2020, European respiratory journal, 55, 1901849. A1 Journal article (refereed), original research

The hypoxic burden: also known as the desaturation severity parameter

Leppänen, Timo; Kulkas, Antti; Töyräs, Juha, 2019, European heart journal, 40, 35, 2991-2993. B1 Non-refereed journal articles

Differences in arousal probability and duration after apnea and hypopnea events in adult obstructive sleep apnea patients

Leppänen, Timo; Kulkas, Antti; Oksenberg, Arie; Duce, Brett; Mervaala, Esa; Töyräs, Juha, 2018, Physiological measurement, 39, 11, 114004. A1 Journal article (refereed), original research

Increase in Body Mass Index Decreases Duration of Apneas and Hypopneas in Obstructive Sleep Apnea

Leppänen, Timo; Kulkas, Antti; Mervaala, Esa; Töyräs, Juha, 2018, Respiratory care, 2019; 64, 1, 77-84. A1 Journal article (refereed), original research

Required CPAP usage time to normalize AHI in obstructive sleep apnea patients: a simulation study

Kulkas, Antti; Leppänen, Timo; Nikkonen, Sami; Oksenberg, Arie; Duce, Brett; Mervaala, Esa; Töyräs, Juha, 2018, Physiological measurement, 39, 11, 115009. A1 Journal article (refereed), original research

Simulation of Required CPAP Usage to Normalize AHI in Obstructive Sleep Apnea Patients

Kulkas, Antti; Nikkonen, Sami; Töyräs, Juha; Mervaala, Esa; Leppänen, Timo, 2018, Lhotska, L; Sukupova, L; Lackovic, I; Ibbott, G, World Congress on Medical Physics and Biomedical Engineering 2018, June 3-8, 2018, Prague, Czech Republic (Vol.2), 129-132. A4 Conference proceedings

Gender differences in severity of desaturation events following hypopnea and obstructive apnea events in adults during sleep

Kulkas Antti, Duce Brett, Leppänen Timo, Hukins Craig, Töyräs Juha, 2017, Physiological measurement, 38, 8, 1490-1502. A1 Journal article (refereed), original research

Severity of desaturation events differs between hypopnea and obstructive apnea events and is modulated by their duration in obstructive sleep apnea

Kulkas Antti, Duce Brett, Leppänen Timo, Hukins Craig, Töyräs Juha, 2017, Sleep and breathing, 21, 4, 829-835. A1 Journal article (refereed), original research

Severity of individual obstruction events increases with age in patients with obstructive sleep apnea

Leppänen Timo, Töyräs Juha, Mervaala Esa, Penzel Thomas, Kulkas Antti, 2017, Sleep medicine, 37, 32-37. A1 Journal article (refereed), original research

The prevalence of REM-related obstructive sleep apnoea is reduced by the AASM 2012 hypopnoea criteria

Duce Brett, Kulkas Antti, Langton Christian, Töyräs Juha, Hukins Craig, 2017, Sleep and breathing, 2018; 22, 1, 57-64. A1 Journal article (refereed), original research

Amsterdam positional OSA classification: the AASM 2012 recommended hypopnoea criteria increases the number of positional therapy candidates

Duce B, Kulkas A, Langton C, Töyräs J, Hukins C, 2016, Sleep and breathing, First Online: 11 November 2016, 1-7. A1 Journal article (refereed), original research

Length of Individual Apnea Events Is Increased by Supine Position and Modulated by Severity of Obstructive Sleep Apnea

Leppänen Timo, Töyräs Juha, Muraja-Murro Anu, Kupari Salla, Tiihonen Pekka, Mervaala Esa, Kulkas Antti, 2016, Sleep disorders, 2016, 1-13. A1 Journal article (refereed), original research

RemLogic plug-in enables clinical application of apnea-hypopnea index adjusted for severity of individual obstruction events

Leppänen Timo, Särkkä Mikko, Kulkas Antti, Muraja-Murro Anu, Kupari Salla, Anttonen Meri, Tiihonen Pekka, Mervaala Esa, Töyräs Juha, 2016, Journal of medical engineering and technology, 40, 3, 119-126. A1 Journal article (refereed), original research

Severity of individual obstruction events is gender dependent in sleep apnea

Leppänen Timo, Kulkas Antti, Duce Brett, Mervaala Esa, Töyräs Juha, 2016, Sleep and breathing, First Online: 13 December 2016, 1-8. A1 Journal article (refereed), original research

Desaturation event characteristics and mortality risk in severe sleep apnea

Kulkas A, Muraja-Murro A, Leppänen T, Tiihonen P, Mervaala E, Töyräs J, 2015, Jaffray David A (ed.), World Congress on Medical Physics and Biomedical Engineering, June 7-12, 2015, Toronto, Canada, 950-953. A3 Book section, Chapters in research books

Effect of different oxygen desaturation threshold levels on hypopnea scoring and classification of severity of sleep apnea

Myllymaa Sami, Myllymaa Katja, Kupari Salla, Kulkas Antti, Leppänen Timo, Tiihonen Pekka, Mervaala Esa, Seppä Juha, Tuomilehto Henri, Töyräs Juha, 2015, Sleep and breathing, 19, 3, 947-954. A1 Journal article (refereed), original research

Effect of oxygen desaturation threshold on determination of OSA severity during weight loss

Myllymaa Katja, Myllymaa Sami, Leppänen Timo, Kulkas Antti, Kupari Salla, Tiihonen Pekka, Mervaala Esa, Seppä Juha, Tuomilehto Henri, Töyräs Juha, 2015, Sleep and breathing, 2016; 20, 1, 33-42. A1 Journal article (refereed), original research

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Publications

Community prevalence of positional obstructive sleep apnea

Beat-to-beat cardiac repolarization lability increases during hypoxemia and arousals in obstructive sleep apnea patients

Morbid obesity influences the nocturnal electrocardiogram wave and interval durations among suspected sleep apnea patients

Obstructive Sleep Apnea Patients With Atrial Arrhythmias Suffer From Prolonged Recovery From Desaturations

Review and perspective on sleep-disordered breathing research and translation to clinics

Diabetes and cardiovascular diseases are associated with the worsening of intermittent hypoxaemia

Comparison of the effect of weight change, simulated computational continuous positive airway pressure treatment and positional therapy on severity of sleep apnea

Increased nocturnal arterial pulsation frequencies of obstructive sleep apnoea patients is associated with an increased number of lapses in a psychomotor vigilance task

Longer duration electroencephalogram arousals have a better relationship with impaired vigilance and health status in obstructive sleep apnoea

Polysomnographic characteristics of severe obstructive sleep apnea vary significantly between hypertensive and normotensive patients of both genders

Power spectral densities of nocturnal pulse oximetry signals differ in OSA patients with and without daytime sleepiness

Severe Desaturations Increase PVT-based Median Reaction Time and Number of Lapses in OSA Patients

The hypoxic burden: also known as the desaturation severity parameter

Differences in arousal probability and duration after apnea and hypopnea events in adult obstructive sleep apnea patients

Increase in Body Mass Index Decreases Duration of Apneas and Hypopneas in Obstructive Sleep Apnea

Required CPAP usage time to normalize AHI in obstructive sleep apnea patients: a simulation study

Simulation of Required CPAP Usage to Normalize AHI in Obstructive Sleep Apnea Patients

Gender differences in severity of desaturation events following hypopnea and obstructive apnea events in adults during sleep

Severity of desaturation events differs between hypopnea and obstructive apnea events and is modulated by their duration in obstructive sleep apnea

Severity of individual obstruction events increases with age in patients with obstructive sleep apnea

The prevalence of REM-related obstructive sleep apnoea is reduced by the AASM 2012 hypopnoea criteria

Amsterdam positional OSA classification: the AASM 2012 recommended hypopnoea criteria increases the number of positional therapy candidates

Length of Individual Apnea Events Is Increased by Supine Position and Modulated by Severity of Obstructive Sleep Apnea

RemLogic plug-in enables clinical application of apnea-hypopnea index adjusted for severity of individual obstruction events

Severity of individual obstruction events is gender dependent in sleep apnea

Desaturation event characteristics and mortality risk in severe sleep apnea

Effect of different oxygen desaturation threshold levels on hypopnea scoring and classification of severity of sleep apnea

Effect of oxygen desaturation threshold on determination of OSA severity during weight loss