Arto Urtti
Professor
Professor of Biopharmaceutics
School of Pharmacy, Faculty of Health Sciences
arto.urtti@uef.fi | +358 40 355 3061
0403553061
040 3553061
040 355 3061
+358 40 355 3061
+35840 355 3061
040 3553 061
+358 40 3553 061
+35840 3553 061
+358 40 3553061
+35840 3553061
+358403553061
040 3553061
040 355 3061
+358 40 355 3061
+35840 355 3061
040 3553 061
+358 40 3553 061
+35840 3553 061
+358 40 3553061
+35840 3553061
+358403553061
Research work is focused on drug delivery and targeting. The research programme includes aspects of pharmacokinetics and modeling, drug formulation and nanotechnology .
Research groups
Keywords
Publications
323 items-
Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues
Hammid, Anam; Fallon, John K; Vellonen, Kati Sisko; Lassila, Toni; Reinisalo, Mika; Urtti, Arto; Gonzalez, Francisco; Tolonen, Ari; Smith, Philip C; Honkakoski, Paavo. 2023. European journal of pharmaceutical sciences. 191: . 106603 -
Intravitreal CendR peptides target laser-induced choroidal neovascularization sites in mice
Puranen, Jooseppi; Korhonen, Sonja; Haugas, Maarja; Lingasamy, Prakash; Teesalu, Tambet; Subrizi, Astrid; Urtti, Arto; Ruponen, Marika; Reinisalo, Mika. 2023. Journal of controlled release. 360: 810-817 -
Mass spectrometry in ocular drug research
del Amo, Eva M.; Vellonen, Kati‐Sisko; Urtti, Arto; Terasaki, Tetsuya; Hammid, Anam; Honkakoski, Paavo; Auriola, Seppo. 2023. Mass spectrometry reviews. [First published: 02 August 2023]: 1-32 -
Quantitative intravitreal pharmacokinetics in mouse as a step towards inter-species translation
Puranen, Jooseppi; Ranta, Veli-Pekka; Ruponen, Marika; Urtti, Arto; Sadeghi, Amir. 2023. Experimental eye research. 235: -
Selective drug delivery to the retinal cells: Biological barriers and avenues
Ramsay, Eva; Lajunen, Tatu; Bhattacharya, Madhushree; Reinisalo, Mika; Rilla, Kirsi; Kidron, Heidi; Terasaki, Tetsuya; Urtti, Arto. 2023. Journal of controlled release. 361: 1-19 -
Tailoring surface properties of liposomes for dexamethasone intraocular administration
Al-Amin, M.D.; Mastrotto, Francesca; Subrizi, Astrid; Sen, Merve; Turunen, Tiina; Arango-Gonzalez, Blanca; Ueffing, Marius; Malfanti, Alessio; Urtti, Arto; Salmaso, Stefano; Caliceti, Paolo. 2023. Journal of controlled release. 354: 323-336 -
The prophylactic value of TNF‐α inhibitors against retinal cell apoptosis and optic nerve axon loss after corneal surgery or trauma
Paschalis, Eleftherios I; Zhou, Chengxin; Sharma, Jyoti; Dohlman, Thomas H; Kim, Sarah; Lei, Fengyang; Chodosh, James; Vavvas, Demetrios; Urtti, Arto; Papaliodis, George; Dohlman, Claes H. 2023. Acta ophthalmologica. [Epub ahead of print Oct 6 2023]: 1-14 -
Topical pharmacokinetics of brinzolamide suspensions in rabbits and variability analysis for sample size and design considerations
Naageshwaran, Vatsala; Bigonne, Hélène; Gum, Glenwood; Malla, Spundana; del Sol, Charity; Bon, Charles; Xu, Xiaoming; Vo, Anh; Smith, William; O'Reilly Beringhs, Andre; Kozak, Darby; Tan, Ming Liang; Babiskin, Andrew; Urtti, Arto; del Amo, Eva M.; Ranta, Veli Pekka. 2023. International journal of pharmaceutics. 642: . 123183 -
5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery
Kalinin, Stanislav; Kovalenko, Alexander; Valtari, Annika; Nocentini, Alessio; Gureev, Maxim; Urtti, Arto; Korsakov, Mikhail; Supuran, Claudiu T.; Krasavin, Mikhail. 2022. Journal of enzyme inhibition and medicinal chemistry. 37: 1005-1011 -
A Novel Ferroptosis Inhibitor UAMC-3203, a Potential Treatment for Corneal Epithelial Wound
Balla, Anusha; Tran, Bao; Valtari, Annika; Steven, Philipp; Scarpellini, Camilla; Augustyns, Koen; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. 2022. Pharmaceutics. 2023; 15: -
Activity and expression of carboxylesterases and arylacetamide deacetylase in human ocular tissues
Hammid, Anam; Fallon, John K; Lassila, Toni; Vieiro, Paula; Balla, Anusha; Gonzalez, Francisco; Urtti, Arto; Smith, Philip C; Tolonen, Ari; Honkakoski, Paavo. 2022. Drug metabolism and disposition. 50: 1483-1492 -
Antiangiogenic AAV2 gene therapy with a truncated form of soluble VEGFR-2 reduces the growth of choroidal neovascularization in mice after intravitreal injection
Puranen, Jooseppi; Koponen, Sanna; Nieminen, Tiina; Kanerva, Iiris; Kokki, Emmi; Toivanen, Pyry; Urtti, Arto; Ylä-Herttuala, Seppo; Ruponen, Marika. 2022. Experimental eye research. 224: -
Comments on “Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials”
del Amo, Eva M; Urtti, Arto; Ranta, Veli-Pekka. 2022. Journal of pharmacology and experimental therapeutics. 383: 246-247 -
Imaging, quantitation and kinetic modelling of intravitreal nanomaterials
Sadeghi, Amir; Ruponen, Marika; Puranen, Jooseppi; Cao, Shoupeng; Ridolfo, Roxane; Tavakoli, Shirin; Toropainen, Elisa; Lajunen, Tatu; Ranta, Veli-Pekka; van Hest, Jan; Urtti, Arto. 2022. International journal of pharmaceutics. 621: -
Improved ocular delivery of quercetin and resveratrol: A comparative study between binary and ternary cyclodextrin complexes
Krstić, Luna; Jarho, Pekka; Ruponen, Marika; Urtti, Arto; González-García, María J.; Diebold, Yolanda. 2022. International journal of pharmaceutics. 624: -
Liposomal sunitinib for ocular drug delivery: A potential treatment for choroidal neovascularization
Tavakoli, Shirin; Puranen, Jooseppi; Bahrpeyma, Sina; Lautala, Veera E.; Karumo, Suvi; Lajunen, Tatu; del Amo, Eva M.; Ruponen, Marika; Urtti, Arto. 2022. International journal of pharmaceutics. 620: -
Mechanisms of cellular retention of melanin bound drugs: Experiments and computational modeling
Bahrpeyma, Sina; Reinisalo, Mika; Hellinen, Laura; Auriola, Seppo; del Amo, Eva M; Urtti, Arto. 2022. Journal of controlled release. 348: 760-770 -
Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations
del Amo, Eva M.; Hammid, Anam; Tausch, Melanie; Toropainen, Elisa; Sadeghi, Amir; Valtari, Annika; Puranen, Jooseppi; Reinisalo, Mika; Ruponen, Marika; Urtti, Arto; Sauer, Achim; Honkakoski, Paavo. 2022. International journal of pharmaceutics. 613: -
Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery
Huttunen, Kristiina M.; Terasaki, Tetsuya; Urtti, Arto; Montaser, Ahmed B.; Uchida, Yasuo. 2022. Pharmaceutical research. 39: 1363-1392 -
Quantitative pharmacokinetic analyses of anterior and posterior elimination routes of intravitreal anti-VEGF macromolecules using published human and rabbit data
Lamminsalo, Marko; Urtti, Arto; Ranta, Veli-Pekka. 2022. Experimental eye research. 222: -
Swarms of chemically modified antiviral siRNA targeting herpes simplex virus infection in human corneal epithelial cells
Kalke, Kiira; Lund, Liisa M.; Nyman, Marie C.; Levanova, Alesia A.; Urtti, Arto; Poranen, Minna M.; Hukkanen, Veijo; Paavilainen, Henrik. 2022. PLoS pathogens. 18: -
The Effect of Microbubble-Assisted Ultrasound on Molecular Permeability across Cell Barriers
Rousou, Charis; de Maar, Josanne; Qiu, Boning; van der Wurff-Jacobs, Kim; Ruponen, Marika; Urtti, Arto; Oliveira, Sabrina; Moonen, Chrit; Storm, Gert; Mastrobattista, Enrico; Deckers, Roel. 2022. Pharmaceutics. 14: -
Topical pharmacokinetics of dexamethasone suspensions in the rabbit eye: Bioavailability comparison
Naageshwaran, Vatsala; Ranta, Veli-Pekka; Toropainen, Elisa; Tuomainen, Marjo; Gum, Glenwood; Xie, Enli; Bhoopathy, Siddhartha; Urtti, Arto; del Amo, Eva M. 2022. International journal of pharmaceutics. 615: -
Understanding dexamethasone kinetics in the rabbit tear fluid: Drug release and clearance from solution, suspension and hydrogel formulations
Balla, Anusha; Ruponen, Marika; Valtari, Annika; Toropainen, Elisa; Tuomainen, Marjo; Alvarez-Lorenzo, Carmen; del Amo, Eva M.; Urtti, Arto; Vellonen, Kati-Sisko. 2022. European journal of pharmaceutics and biopharmaceutics. 172: 53-60 -
Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin
Toropainen, Elisa; Fraser-Miller, Sara J; Novakovic, Dunja; Del Amo, Eva M; Vellonen, Kati-Sisko; Ruponen, Marika; Viitala, Tapani; Korhonen, Ossi; Auriola, Seppo; Hellinen, Laura; Reinisalo, Mika; Tengvall, Unni; Choi, Stephanie; Absar, Mohammad; Strachan, Clare; Urtti, Arto. 2021. Pharmaceutics. 13: 452 -
Carboxylesterase Activities and Protein Expression in Rabbit and Pig Ocular Tissues
Hammid, Anam; Fallon, John K; Lassila, Toni; Salluce, Giulia; Smith, Philip C; Tolonen, Ari; Sauer, Achim; Urtti, Arto; Honkakoski, Paavo. 2021. Molecular pharmaceutics. 18: 1305-1316 -
Conformationally Constrained Peptides with High Affinity to the Vascular Endothelial Growth Factor
Guryanov, I; Korzhikov-Vlakh, V; Bhattacharya, M; Biondi, B; Masiero, G; Formaggio, F; Tennikova, T; Urtti, A. 2021. Journal of medicinal chemistry. 64: 10900-10907 -
Cowpea Chlorotic Mottle Virus-Like Particles as Potential Platform for Antisense Oligonucleotide Delivery in Posterior Segment Ocular Diseases
Pretto, Chiara; Tang, Miao; Chen, Mei; Xu, Heping; Subrizi, Astrid; Urtti, Arto; Hest, Jan CM. 2021. Macromolecular bioscience. 21: 2100095 -
Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration
Hellinen, Laura; Koskela, Ali; Vattulainen, Elina; Liukkonen, Mikko; Wegler, Christine; Treyer, Andrea; Handin, Niklas; Svensson, Richard; Myöhänen, Timo; Poso, Antti; Kaarniranta, Kai; Artursson, Per; Urtti, Arto. 2021. Biomedicine and pharmacotherapy. 2022; 146: 112501 -
Intravitreal Polymeric Nanocarriers with Long Ocular Retention and Targeted Delivery to the Retina and Optic Nerve Head Region
Junnuthula, Vijayabhaskarreddy; Sadeghi Boroujeni, Amir; Cao, Shoupeng; Tavakoli, Shirin; Ridolfo, Roxane; Toropainen, Elisa; Ruponen, Marika; van Hest, Jan CM; Urtti, Arto. 2021. Pharmaceutics. 13: 445 -
Magnetically Assisted Drug Delivery of Topical Eye Drops Maintains Retinal Function In Vivo in Mice
Bassetto M, Ajoy D, Poulhes F, Obringer C, Walter A, Messadeq N, Sadeghi A, Puranen J, Ruponen M, Kettunen M, Toropainen E, Urtti A, Dollfus H, Zelphati O, Marion V. 2021. Pharmaceutics. 13: 1650 -
Mucoadhesive properties of nanogels based on stimuli-sensitive glycosaminoglycan-graft-pNIPAAm copolymers
Pilipenko, Iuliia; Korzhikov-Vlakh, Viktor; Valtari, Annika; Anufrikov, Yurii; Kalinin, Stanislav; Ruponen, Marika; Krasavin, Mikhail; Urtti, Arto; Tennikova, Tatiana. 2021. International journal of biological macromolecules. 186: 864-872 -
Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye
Fayyaz, Anam; Vellonen, Kati-Sisko; Ranta, Veli-Pekka; Toropainen, Elisa; Reinisalo, Mika; Valtari, Annika; Puranen, Jooseppi; D'Amico Ricci, Giuseppe; Heikkinen, Emma M.; Gardner, Iain; Ruponen, Marika; Urtti, Arto; Jamei, Masoud; del Amo, Eva M. 2021. European journal of pharmaceutics and biopharmaceutics. 166: 155-162 -
Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3
Sridevi Gurubaran, Iswariyaraja; Heloterä, Hanna; Marry, Stephen; Koskela, Ali; Hyttinen, Juha MT; Paterno, Jussi J; Urtti, Arto; Chen, Mei; Xu, Heping; Kauppinen, Anu; Kaarniranta, Kai. 2021. Biology. 10: 622 -
Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues
Balla, Anusha; Auriola, Seppo; Grey, Angus C; Demarais, Nicholas J; Valtari, Annika; Heikkinen, Emma M; Toropainen, Elisa; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. 2021. Pharmaceutics. 13: 658 -
Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives
Guryanov, Ivan; Tennikova, Tatiana; Urtti, Arto. 2021. Pharmaceutics. 13: 1337 -
Pharmacokinetics of Pullulan–Dexamethasone Conjugates in Retinal Drug Delivery
Kicková, Eva; Sadeghi, Amir; Puranen, Jooseppi; Tavakoli, Shirin; Sen, Merve; Ranta, Veli-Pekka; Arango-Gonzalez, Blanca; Bolz, Sylvia; Ueffing, Marius; Salmaso, Stefano; Caliceti, Paolo; Toropainen, Elisa; Ruponen, Marika; Urtti, Arto. 2021. Pharmaceutics. 2022; 14: -
Pharmacokinetics of intravitreal macromolecules: scaling between rats and rabbits
Sadeghi, Amir; Puranen, Jooseppi; Ruponen, Marika; Valtari, Annika; Subrizi, Astrid; Ranta, Veli-Pekka; Toropainen, Elisa; Urtti, Arto. 2021. European journal of pharmaceutical sciences. 159: 105720 -
Pullulan Based Bioconjugates for Ocular Dexamethasone Delivery
Kicková, Eva; Salmaso, Stefano; Mastrotto, Francesca; Caliceti, Paolo; Urtti, Arto. 2021. Pharmaceutics. 13: 791 -
Retinal neuroprotection by controlled release of a VCP inhibitor from self-assembled nanoparticles
Sen, Merve; Al-Amin, M.D.; Kicková, Eva; Sadeghi, Amir; Puranen, Jooseppi; Urtti, Arto; Caliceti, Paolo; Salmaso, Stefano; Arango-Gonzalez, Blanca; Ueffing, Marius. 2021. Journal of controlled release. 339: 307-320 -
Screening of chemical linkers for development of pullulan bioconjugates for intravitreal ocular
Balasso, Anna; Subrizi, Astrid; Salmaso, Stefano; Mastrotto, Francesca; Garofalo, Mariangela; Tang, Miao; Chen, Mei; Xu, Heping; Urtti, Arto; Caliceti, Paolo. 2021. European journal of pharmaceutical sciences. 161: 105785 -
Statins for the prevention of proliferative vitreoretinopathy: cellular responses in cultured cells and clinical statin concentrations in the vitreous
Mysore, Yashavanthi; del Amo, Eva M; Loukovaara, Sirpa; Hagström, Marja; Urtti, Arto; Kauppinen, Anu. 2021. Scientific reports. 11: 980 -
Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application
Rousou, Charis; Schuurmans, Carl C. L.; Urtti, Arto; Mastrobattista, Enrico; Storm, Gert; Moonen, Chrit; Kaarniranta, Kai; Deckers, Roel. 2021. Pharmaceutics. 13: 1782 -
Amphiphilic Polypeptides for VEGF siRNA Delivery into Retinal Epithelial Cells
Osipova, O; Sharoyko, V; Zashikhina, N; Zakharova, N; Tennikova, T; Urtti, A; Korzhikova-Vlakh, E. 2020. Pharmaceutics. 12: 39 -
Avoiding the Pitfalls of siRNA Delivery to the Retinal Pigment Epithelium with Physiologically Relevant Cell Models.
Ramsay, Eva; Raviña, Manuela; Sarkhel, Sanjay; Hehir, Sarah; Cameron, Neil R; Ilmarinen, Tanja; Skottman, Heli; Kjems, Jørgen; Urtti, Arto; Ruponen, Marika; Subrizi, Astrid. 2020. Pharmaceutics. 12: 667 -
Characterization, Stability, and in Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation Into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models
Itkonen, Jaakko; Annala, Ada; Tavakoli, Shirin; Arango-Gonzalez, Blanca; Ueffing, Marius; Toropainen, Elisa; Ruponen, Marika; Casteleijn, Marco G; Urtti, Arto. 2020. Pharmaceutics. 12: E611 -
Comprehensive Ocular and Systemic Pharmacokinetics of Brinzolamide in Rabbits After Intracameral, Topical, and Intravenous Administration
Naageshwaran, Vatsala; Ranta, Veli-Pekka; Gum, Glenwood; Bhoopathy, Siddhartha; Urtti, Arto; del Amo, Eva M. 2020. Journal of pharmaceutical sciences. 2021; 110: 529-535 -
Design and synthesis of lipid-mimetic cationic iridium complexes and their liposomal formulation for in vitro and in vivo application in luminescent bioimaging
Shakirova, Julia R; Sadeghi, Amir; Koblova, Alla A; Chelushkin, Pavel S; Toropainen, Elisa; Tavakoli, Shirin; Kontturi, Leena-Stiina; Lajunen, Tatu; Tunik, Sergey P; Urtti, Arto. 2020. Rsc advances. 10: 14431-14440 -
Diffusion and Protein Corona Formation of Lipid-Based Nanoparticles in the Vitreous Humor: Profiling and Pharmacokinetic Considerations
Tavakoli, Shirin; Kari, Otto Kalevi; Turunen, Tiina; Lajunen, Tatu; Schmitt, Mechthild; Lehtinen, Julia; Tasaka, Fumitaka; Parkkila, Petteri; Ndika, Joseph; Viitala, Tapani; Alenius, Harri; Urtti, Arto; Subrizi, Astrid. 2020. Molecular pharmaceutics. 2021; 18: 699-713 -
Extended Pharmacokinetic Model of the Intravitreal Injections of Macromolecules in Rabbits. Part 2: Parameter Estimation Based on Concentration Dynamics in the Vitreous, Retina, and Aqueous Humor
Lamminsalo, Marko; Karvinen, Timo; Subrizi, Astrid; Urtti, Arto; Ranta, Veli-Pekka. 2020. Pharmaceutical research. 37: 226 -
Hexosome engineering for targeting of regional lymph nodes
Helvig, Shen Y; Andersen, Helene; Antopolsky, Maxim; Airaksinen, Anu J; Urtti, Arto; Yaghmur, Anan; Moghimi, Seyed M. 2020. Materialia. 11: 100705 -
Intravitreal hydrogels for sustained release of therapeutic proteins
Ilochonwu, Blessing C; Urtti, Arto; Hennink, Wim E; Vermonden, Tina. 2020. Journal of controlled release. 326: 419-441 -
Light-Activated Liposomes Coated with Hyaluronic Acid as a Potential Drug Delivery System
Kari, Otto K; Tavakoli, Shirin; Parkkila, Petteri; Baan, Simone; Savolainen, Roosa; Ruoslahti, Teemu; Johansson, Niklas G; Ndika, Joseph; Alenius, Harri; Viitala, Tapani; Urtti, Arto; Lajunen, Tatu. 2020. Pharmaceutics. 12: 763 -
Microflow-Based Device for In Vitro and Ex Vivo Drug Permeability Studies
Hemmilä, Samu; Ruponen, Marika; Toropainen, Elisa; Tengvall-Unadike, Unni; Urtti, Arto; Kallio, Pasi. 2020. SLAS technology. 25: 455-462 -
Microscale Thermophoresis as a Screening Tool to Predict Melanin Binding of Drugs
Hellinen, Laura; Bahrpeyma, Sina; Rimpelä, Anna-Kaisa; Hagström, Marja; Reinisalo, Mika; Urtti, Arto. 2020. Pharmaceutics. 12: 554 -
Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model
Sridevi Gurubaran, Iswariyaraja; Viiri, Johanna; Koskela, Ali; Hyttinen, Juha M; Paterno, Jussi; Kis, Gréta; Antal, Miklós; Urtti, Arto; Kauppinen, Anu; Felszeghy, Szabolcs; Kaarniranta, Kai. 2020. International journal of molecular sciences. 21: 1976 -
Ocular barriers to retinal delivery of intravitreal liposomes: Impact of vitreoretinal interface
Tavakoli, Shirin; Peynshaert, Karen; Lajunen, Tatu; Devoldere, Joke; Del Amo, Eva M; Ruponen, Marika; De Smedt, Stefaan C; Remaut, Katrien; Urtti, Arto. 2020. Journal of controlled release. 328: 952-961 -
Prodrug Approach for Posterior Eye Drug Delivery: Synthesis of Novel Ganciclovir Prodrugs and in Vitro Screening with Cassette Dosing
Heikkinen, Emma M; Ruponen, Marika; Jasper, Lisa-Marie; Leppänen, Jukka; Hellinen, Laura; Urtti, Arto; Auriola, Seppo; Rautio, Jarkko; Vellonen, Kati-Sisko. 2020. Molecular pharmaceutics. 17: 1945-1953 -
Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery
Bhattacharya, Madhushree; Sadeghi, Amir; Sarkhel, Sanjay; Hagström, Marja; Bahrpeyma, Sina; Toropainen, Elisa; Auriola, Seppo; Urtti, Arto. 2020. Journal of controlled release. 327: 584-594 -
The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy
Kilpeläinen, Tommi P; Hellinen, Laura; Vrijdag, Johannes; Yan, Xu; Svarcbahs, Reinis; Vellonen, Kati-Sisko; Lambeir, Anne-Marie; Huttunen, Henri; Urtti, Arto; Wallen, Erik; Myöhänen, Timo. 2020. Biomedicine and pharmacotherapy. 128: 110253 -
Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits
Fayyaz, Anam; Ranta, Veli-Pekka; Toropainen, Elisa; Vellonen, Kati-Sisko; Valtari, Annika; Puranen, Jooseppi; Ruponen, Marika; Gardner, Iain; Urtti, Arto; Jamei, Masoud; del Amo, Eva M.. 2020. European journal of pharmaceutical sciences. 155: 105553 -
Artificially cloaked viral nanovaccine for cancer immunotherapy
Fusciello, M; Fontana, F; Tähtinen, S; Capasso, C; Feola, S; Martins, B; Chiaro, J; Peltonen, K; Ylösmäki, L; Ylösmäki, E; Hamdan, F; Kari, OK; Ndika, J; Alenius, H; Urtti, A; Hirvonen, JT; Santos, HA; Cerullo, V. 2019. Nature communications. 10: 5747 -
CD44 aptamer mediated cargo delivery to lysosomes of retinal pigment epithelial cells to prevent age-related macular degeneration
Chandola, C; Casteleijn, MG; Chandola, UM; Gopalan, LN; Urtti, A; Neerathilingam, M. 2019. Biochemistry and biophysics reports. 18: 100642 -
Characterization of CDNF-Secreting ARPE-19 Cell Clones for Encapsulated Cell Therapy
Galli, E; Lindholm, P; Kontturi, LS; Saarma, M; Urtti, A; Yliperttula, M. 2019. Cell transplantation. 28: 412-424 -
Characterization of artificially re-pigmented ARPE-19 retinal pigment epithelial cell model
Hellinen, L; Hagström, M; Knuutila, H; Ruponen, M; Urtti, A; Reinisalo, M. 2019. Scientific reports. 9: 13761 -
Comment on "Topical Delivery of Avastin to the Posterior Segment of the Eye In Vivo Using Annexin A5-Associated Liposomes": Topical Liposomal Bevacizumab Results in Negligible Retinal Concentrations
Urtti, Arto. 2019. Small. 15: 1805199 -
Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties
Subrizi, A; Amo, EMD; Korzhakov-Vlakh, V; Tennikova, T; Ruponen, M; Urtti, A. 2019. Drug discovery today. 24: 1446-1457 -
Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics
Heikkinen, EM; Auriola, S; Ranta, VP; Demarais, N; Grey, A; Del Amo, E; Toropainen, E; Vellonen, KS; Urtti, A; Ruponen, M. 2019. Molecular pharmaceutics. 16: 3968-3976 -
Electrical synapses interconnecting axons revealed in the optic nerve head - a novel model of gap junctions' involvement in optic nerve function
Smedowski, A; Akhtar, S; Liu, X; Pietrucha-Dutczak, M; Podracka, L; Toropainen, E; Alkanaan, A; Ruponen, M; Urtti, A; Varjosalo, M; Kaarniranta, K; Lewin-Kowalik, J. 2019. Acta ophthalmologica. [Epub ahead of print 10 Oct 2019]: 1-10 -
Electron dispersive X-ray spectroscopy and degradation properties of hyaluronic acid decorated microparticles
Serri, Carla; Frigione, Mariaenrica; Ruponen, Marika; Urtti, Arto; Borzacchiello, Assunta; Biondi, Marco; Mayol, Laura. 2019. Colloids and surfaces b: biointerfaces. 181: 896-901 -
Enhanced Delivery of 4-Thioureidoiminomethylpyridinium Perchlorate in Tuberculosis Models with IgG Functionalized Poly(Lactic Acid)-Based Particles
Churilov, Leonid; Korzhikov-Vlakh, Viktor; Sinitsyna, Ekaterina; Polyakov, Dmitry; Darashkevich, Oleg; Poida, Mikhail; Platonova, Galina; Vinogradiva, Tatiana; Utekhin, Vladimir; Zabolotnykh, Natalia; Zinserling, Vsevolod; Yablonsky, Peter; Urtti, Arto; Tennikova, Tatiana. 2019. Pharmaceutics. 11: 2 -
Establishment of an In Vitro-In Vivo Correlation for Melanin Binding and the Extension of the Ocular Half-Life of Small-Molecule Drugs
Jakubiak, Paulina; Cantrill, Carina; Urtti, Arto; Alvarez-Sanchez, Ruben. 2019. Molecular pharmaceutics. 16: 4890-4901 -
Exploring Light-Sensitive Nanocarriers for Simultaneous Triggered Antibiotic Release and Disruption of Biofilms Upon Generation of Laser-Induced Vapor Nanobubbles
Teirlinck, E; Barras, A; Liu, J; Fraire, JC; Lajunen, T; Xiong, R; Forier, K; Li, C; Urtti, A; Boukherroub, R; Szunerits, S; De Smedt, SC; Coenye, T; Braeckmans, K. 2019. Pharmaceutics. 11: 201 -
Exploring the mucoadhesive behavior of sucrose acetate isobutyrate: a novel excipient for oral delivery of biopharmaceuticals
Harloff-Helleberg, S; Fliervoet, LAL; Fanø, M; Schmitt, M; Antopolski, M; Urtti, A; Nielsen, HM. 2019. Drug delivery. 26: 532-541 -
Highly Hydrophilic 1,3-Oxazol-5-yl Benzenesulfonamide Inhi bitors of Carbonic Anhydrase II for Reduction of Glaucoma-Related Intraocular Pressure
Kalinin, Stanislav; Valtari, Annika; Ruponen, Marika; Toropainen, Elisa; Kovalenko, Alexander; Nocentini, Alessio; Gureev, Maxim; Dar'in, Dmitry; Urtti, Arto; Supuran, Claudiu T; Krasavin, Mikhail. 2019. Bioorganic and medicinal chemistry. 27: 115086 -
ISOPT Clinical Hot Topic Panel Discussion on Ocular Drug Delivery
Kompella, UB; Domb, A; Urtti, A; Jayagopal, A; Wilson, CG; Tang-Liu, D. 2019. Journal of ocular pharmacology and therapeutics. 35: 457-465 -
In situ analysis of liposome hard and soft protein corona structure and composition in a single label-free workflow
Kari, OK; Ndika, J; Parkkila, P; Louna, A; Lajunen, T; Puustinen, A; Viitala, T; Alenius, H; Urtti, A. 2019. Nanoscale. 2020; 12: 1728-1741 -
Influence of Melanin Characteristics on Drug Binding Properties
Jakubiak, Paulina; Lack, Flavio; Thun, Jurgen; Urtti, Arto; Alvarez-Sanchez, Ruben. 2019. Molecular pharmaceutics. 16: 2549-2556 -
Intravitreal Pharmacokinetics in Mice: SPECT/CT Imaging and Scaling to Rabbits and Humans
Schmitt, Mechthild; Hippeläinen, Eero; Raviña, Manuela; Arango-Gonzalez, Blanca; Antopolsky, Maxim; Vellonen, Kati-Sisko; Airaksinen, Anu J; Urtti, Arto. 2019. Molecular pharmaceutics. 16: 4399-4404 -
Light-Triggered Cellular Delivery of Oligonucleotides
Kontturi, LS; van den Dikkenberg, J; Urtti, A; Hennink, WE; Mastrobattista, E. 2019. Pharmaceutics. 11: 90 -
Modified cells as potential ocular drug delivery systems
Tennikova, Tatiana; Urtti, Arto. 2019. Drug discovery today. 24: 1621-1626 -
Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits
Fayyaz, A; Ranta, VP; Toropainen, E; Vellonen, KS; Ricci, GD; Reinisalo, M; Heikkinen, EM; Gardner, I; Urtti, A; Jamei, M; del Amo, EM. 2019. Molecular pharmaceutics. 12: e007045 -
Pharmacokinetic Simulations of Intravitreal Biologicals: Aspects of Drug Delivery to the Posterior and Anterior Segments
Rimpelä, AK; Kiiski, I; Deng, F; Kidron, H; Urtti, A. 2019. Pharmaceutics. 11: 9 -
Polysaccharides in Ocular Drug Delivery
Dubashynskaya, N; Poshina, D; Raik, S; Urtti, A; Skorik, YA. 2019. Pharmaceutics. 12: 22 -
Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters
Hellinen, Laura; Sato, Kazuki; Reinisalo, Mika; Kidron, Heidi; Rilla, Kirsi; Tachikawa, Masanori; Uchida, Yasuo; Terasaki, Tetsuya; Urtti, Arto. 2019. Investigative ophthalmology and visual science. 60: 5022-5034 -
Retinal Pigment Epithelial Cell Line with Fast Differentiation and Improved Barrier Properties
Hellinen, L; Pirskanen, L; Tengvall-Unadike, U; Urtti, A; Reinisalo, M. 2019. Pharmaceutics. 11: 412 -
Retinal bioavailability of liposomal minocycline after sub-conjunctival administration is low
Urtti, Arto. 2019. Nanomedicine: nanotechnology biology and medicine. 18: 427 -
Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation
Ramsay, E; Hagström, M; Vellonen, KS; Boman, S; Toropainen, E; Del Amo, EM; Kidron, H; Urtti, A; Ruponen, M. 2019. European journal of pharmaceutics and biopharmaceutics. 143: 18-23 -
Accelerated pharmaceutical protein development with integrated cell free expression, purification, and bioconjugation
Richardson, Dominique; Itkonen, Jaakko; Nievas, Julia; Urtti, Arto; Casteleijn, Marco G. 2018. Scientific reports. 8: 11967 -
Binding of Small Molecule Drugs to Porcine Vitreous Humor
Rimpelä, Anna-Kaisa; Reunanen, Saku; Hagström, Marja; Kidron, Heidi; Urtti, Arto. 2018. Molecular pharmaceutics. 15: 2174-2179 -
Biofarmasian perusteet
Ruponen, Marika; Pajula, Katja; Honkakoski, Paavo; Urtti, Arto. 2018. . . Farmasian opiskelijayhdistys Fortis ry -
Biofarmasian perustekijät
Urtti, Arto; Yliperttula, Marjo; Ruponen, Marika. Teoksessa: Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo(toim.) , 2018. Biofarmasian perusteet. s. 17-39. Farmasian opiskelijayhdidtys Fortis ry -
Biofarmasian tulevaisuuden näkymiä
Honkakoski; Paavo; Urtti; Arto. Teoksessa: Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo(toim.) , 2018. Biofarmasian perusteet. s. 201-211. Farmasian opiskelijayhdidtys Fortis ry -
Cisplatin Encapsulation Generates Morphologically Different Multicompartments in the Internal Nanostructures of Nonlamellar Liquid-Crystalline Self-Assemblies
Mat Azmi, Intan Diana; Østergaard, Jesper; Stürup, Stefan; Gammelgaard, Bente; Urtti, Arto; Moghimi, Seyed Moein; Yaghmur, Anan. 2018. Langmuir. 34: 6570-6581 -
Corneal and conjunctival drug permeability : systematic comparison and pharmacokinetic impact in the eye
Ramsay, Eva; del Amo, Eva M; Toropainen, Elisa; Tengvall-Unadike, Unni; Ranta, Veli-Pekka; Urtti, Arto; Ruponen, Marika. 2018. European journal of pharmaceutical sciences. 119: 83-89 -
Esterase activity in porcine and albino rabbit ocular tissues
Heikkinen, Emma M; del Amo, Eva M; Ranta, Veli-Pekka; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. 2018. European journal of pharmaceutical sciences. 123: 106-110 -
Expression, activity and pharmacokinetic impact of ocular transporters
Vellonen, Kati-Sisko; Hellinen, Laura; Mannermaa, Eliisa; Ruponen, Marika; Urtti, Arto; Kidron, Heidi. 2018. Advanced drug delivery reviews. 126: 3-22 -
Extended Pharmacokinetic Model of the Rabbit Eye for Intravitreal and Intracameral Injections of Macromolecules: Quantitative Analysis of Anterior and Posterior Elimination Pathways
Lamminsalo, Marko; Taskinen, Ella; Karvinen, Timo; Subrizi, Astrid; Murtomäki, Lasse; Urtti, Arto: Ranta, Veli-Pekka. 2018. Pharmaceutical research. 35: 153 -
Iho lääkeaineiden antoreittinä
Urtti, Arto; Ruponen, Marika; Pajula, Katja; Vellonen, Kati-Sisko. Teoksessa: Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo(toim.) , 2018. Biofarmasian perusteet. s. 135-148. Farmasian opiskelijayhdidtys Fortis ry -
Implications of melanin binding in ocular drug delivery
Rimpelä, Anna-Kaisa; Reinisalo, Mika; Hellinen, Laura; Grazhdankin, Evgeni; Kidron, Heidi; Urtti Arto; del Amo, Eva M. 2018. Advanced drug delivery reviews. 126: 23-43 -
Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Redox biology. 2019; 20: 1-12 -
Lääkkeenanto laskimoon, lihakseen ja ihan alle
Urtti, Arto; Ruponen, Marika. Teoksessa: Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo(toim.) , 2018. Biofarmasian perusteet. s. 45-55. Farmasian opiskelijayhdidtys Fortis ry -
Melanin targeting for intracellular drug delivery: Quantification of bound and free drug in retinal pigment epithelial cells
Rimpelä, Anna-Kaisa; Hagström, Marja; Kidron, Heidi; Urtti, Arto. 2018. Journal of controlled release. 283: 261-268 -
Preface
Bunt, Craig; Urtti, Arto; Thrimawithana, Thilini. 2018. Advanced drug delivery reviews. 126: 1-2 -
Silmän biofarmasia [Ocular biopharmacy]
Urtti, Arto; Ruponen, Marika; Pajula, Katja; del Amo, Eva. Teoksessa: Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo(toim.) , 2018. Biofarmasian perusteet [Basics of Biopharmacy]. s. 149-163. Farmasian opiskelijayhdidtys Fortis ry -
Spin coated chitin films for biosensors and its analysis are dependent on chitin-surface interactions
Casteleijn, Marco G; Richardson, Dominique; Parkkila, Petteri; Granqvist, Niko; Urtti, Arto; Viitala, Tapani. 2018. Colloids and surfaces a: physicochemical and engineering aspects. 539: 261-272 -
Suun kautta otettujen lääkeaineiden imeytyminen
Urtti, Arto; Ruponen, Marika; Pajula, Katja; Yliperttula, Marjo; Honkakoski, Paavo; Ranta, Veli-Pekka; Kidron, Heidi; Vellonen, Kati-Sisko. Teoksessa: Ruponen, Marika; Urtti, Arto; Pajula, Katja; Honkakoski, Paavo(toim.) , 2018. Biofarmasian perusteet. s. 57-96. Farmasian opiskelijayhdidtys Fortis ry -
The effect of light sensitizer localization on the stability of indocyanine green liposomes
Lajunen, T; Nurmi, R; Wilbie, D; Ruoslahti, T; Johansson, NG; Korhonen, O; Rog, T; Bunker, A; Ruponen, M; Urtti, A. 2018. Journal of controlled release. 284: 213-223 -
Understanding Molecular Drivers of Melanin Binding To Support Rational Design of Small Molecule Ophthalmic Drugs
Jakubiak, Paulina; Reutlinger, Michael; Mattei, Patrizio; Schuler, Franz; Urtti, Arto; Alvarez-Sanchez, Ruben. 2018. Journal of medicinal chemistry. 61: 10106-10115 -
Differentially cleaving peptides as a strategy for controlled drug release in human retinal pigment epithelial cells
Bhattacharya M, Sarkhel S, Peltoniemi J, Broadbridge R, Tuomainen M, Auriola S, Urtti A. 2017. Journal of controlled release. 251: 37-48 -
Hyaluronic Acid Graft Copolymers with Cleavable Arms as Potential Intravitreal Drug Delivery Vehicles
Borke T, Najberg M, Ilina P, Bhattacharya M, Urtti A, Tenhu H, Hietala S. 2017. Macromolecular bioscience. 2018; 18: 1700200 -
Impact of Chemical Structure on Conjunctival Drug Permeability: Adopting Porcine Conjunctiva and Cassette Dosing for Construction of In Silico Model
Ramsay E, Ruponen M, Picardat T, Tengvall U, Tuomainen M, Auriola S, Toropainen E, Urtti A, del Amo EM. 2017. Journal of pharmaceutical sciences. 106: 2463-2471 -
Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells : a possible sign of endogenous neuroprotection failure
Smedowski A, Liu X, Podracka L, Akhtar S, Trzeciecka A, Pietrucha-Dutczak M, Lewin-Kowalik J, Urtti A, Ruponen M, Kaarniranta K, Varjosalo M, Amadio M. 2017. Biochimica et biophysica acta: molecular basis of disease. 2018; 1864: 296-306 -
Inner Blood-Retinal Barrier Dominantly Expresses Breast Cancer Resistance Protein: Comparative Quantitative Targeted Absolute Proteomics Study of CNS Barriers in Pig
Zhang Z, Uchida Y, Hirano S, Ando D, Kubo Y, Auriola S, Akanuma S-I, Hosoya K-I, Urtti A, Terasaki T, Tachikawa M. 2017. Molecular pharmaceutics. 14: 3729-3738 -
LC-MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line
Pelkonen L, Sato K, Reinisalo M, Kidron H, Tachikawa M, Watanabe M, Uchida Y, Urtti A, Terasaki T. 2017. Molecular pharmaceutics. 14: 605-613 -
Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts
Pelkonen L, Tengvall-Unadike U, Ruponen M, Kidron H, del Amo EM, Reinisalo M, Urtti A. 2017. European journal of pharmaceutical sciences. 109: 162-168 -
Nanofibrillar cellulose-alginate hydrogel coated surgical sutures as cell-carrier systems
Laurén P, Somersalo P, Pitkänen I, Lou YR, Urtti A, Partanen J, Seppälä J, Madetoja M, Laaksonen T, Mäkitie A, Yliperttula M. 2017. PLoS ONE. 12: e0183487 -
Pharmacokinetic aspects of retinal drug delivery
del Amo Eva M, Rimpelä Anna-Kaisa, Heikkinen Emma, Kari Otto K, Ramsay Eva, Lajunen Tatu, Schmitt Mechthild, Pelkonen Laura, Bhattacharya Madhushree, Richardson Dominique, Subrizi Astrid, Turunen Tiina, Reinisalo Mika, Itkonen Jaakko, Toropainen Elisa, Casteleijn Marco, Kidron Heidi, Antopolsky Maxim, Vellonen Kati-Sisko, Ruponen Marika, et al.. 2017. Progress in retinal and eye research. 57: 134-185 -
Time-Resolved Fluorescence Spectroscopy Reveals Fine Structure and Dynamics of Poly(l-lysine) and Polyethylenimine Based DNA Polyplexes
Lisitsyna ES, Ketola TM, Morin-Picardat E, Liang H, Hanzlíková M, Urtti A, Yliperttula M, Vuorimaa-Laukkanen E. 2017. Journal of physical chemistry b. 121: 10782-10792 -
Application of aptamers in diagnostics, drug-delivery and imaging
Chandola Chetan, Kalme Sheetal, Casteleijn Marco G, Urtti Arto, Neerathilingam Muniasamy. 2016. Journal of biosciences. 41: 535-561 -
Drug Distribution to Retinal Pigment Epithelium: Studies on Melanin Binding, Cellular Kinetics, and Single Photon Emission Computed Tomography/Computed Tomography Imaging
Rimpelä Anna-Kaisa, Schmitt Mechthild, Latonen Satu, Hagström Marja, Antopolsky Maxim, Manzanares José A, Kidron Heidi, Urtti Arto. 2016. Molecular pharmaceutics. 13: 2977-2986 -
General Pharmacokinetic Model for Topically Administered Ocular Drug Dosage Forms
Deng Feng, Ranta Veli-Pekka, Kidron Heidi, Urtti Arto. 2016. Pharmaceutical research. 33: 2680-2690 -
HDAC inhibition in the cpfl1 mouse protects degenerating cone photoreceptors in vivo
Trifunovic Dragana, Arango-Gonzalez Blanca, Comitato Antonella, Barth Melanie, Del Amo Eva M, Kulkarni Manoj, Sahaboglu Ayse, Hauck Stefanie M, Urtti Arto, Arsenijevic Yvan, Ueffing Marius, Marigo Valeria, Paquet-Durand Francois. 2016. Human molecular genetics. 25: 4462-4472 -
Hepatic differentiation of human pluripotent stem cells on human liver progenitor HepaRG-derived acellular matrix
Kanninen Liisa K, Porola Pauliina, Niklander Johanna, Malinen Melina M, Corlu Anne, Guguen-Guillouzo Christiane, Urtti Arto, Yliperttula Marjo L, Lou Yan-Ru. 2016. Experimental cell research. 341: 207-217 -
Human corneal cell culture models for drug toxicity studies
Rönkkö Seppo, Vellonen Kati-Sisko, Järvinen Kristiina, Toropainen Elisa, Urtti Arto. 2016. Drug delivery and translational research. 6: 660-675 -
Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes
Galli Emilia, Härkönen Taina, Sainio Markus T, Ustav Mart, Toots Urve, Urtti Arto, Yliperttula Marjo, Lindahl Maria, Knip Mikael, Saarma Mart, Lindholm Päivi. 2016. Scientific reports. 6: 29058 -
Indocyanine Green-Loaded Liposomes for Light-Triggered Drug Release
Lajunen Tatu, Kontturi Leena-Stiina, Viitala Lauri, Manna Moutusi, Cramariuc Oana, Róg Tomasz, Bunker Alex, Laaksonen Timo, Viitala Tapani, Murtomäki Lasse, Urtti Arto. 2016. Molecular pharmaceutics. 13: 2095-2107 -
Interpretation of Ocular Melanin Drug Binding Assays. Alternatives to the Model of Multiple Classes of Independent Sites
Manzanares José A, Rimpelä Anna-Kaisa, Urtti Arto. 2016. Molecular pharmaceutics. 13: 1251-1257 -
Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling
Soininen Suvi K, Vellonen Kati-Sisko, Heikkinen Aki T, Auriola Seppo, Ranta Veli-Pekka, Urtti Arto, Ruponen Marika. 2016. Molecular pharmaceutics. 13: 1358-1365 -
Isolation of Intact and Functional Melanosomes from the Retinal Pigment Epithelium
Pelkonen Laura, Reinisalo Mika, Morin-Picardat Emmanuelle, Kidron Heidi, Urtti Arto. 2016. PLoS ONE. 11: e0160352 -
Laminin-511 and laminin-521-based matrices for efficient hepatic specification of human pluripotent stem cells
Kanninen Liisa K, Harjumäki Riina, Peltoniemi Pasi, Bogacheva Mariia S, Salmi Tuuli, Porola Pauliina, Niklander Johanna, Smutný Tomás, Urtti Arto, Yliperttula Marjo L, Lou Yan-Ru. 2016. Biomaterials. 103: 86-100 -
Light activated liposomes: Functionality and prospects in ocular drug delivery
Lajunen Tatu, Nurmi Riikka, Kontturi Leena, Viitala Lauri, Yliperttula Marjo, Murtomäki Lasse, Urtti Arto. 2016. Journal of controlled release. 244: 157-166 -
Multi-parametric surface plasmon resonance platform for studying liposome-serum interactions and protein corona formation
Kari Otto K, Rojalin Tatu, Salmaso Stefano, Barattin Michela, Jarva Hanna, Meri Seppo, Yliperttula Marjo, Viitala Tapani, Urtti Arto. 2016. Drug delivery and translational research. 2017; 7: 228-240 -
Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration
Sahaboglu Ayse, Barth Melanie, Secer Enver, del Amo Eva M, Urtti Arto, Arsenijevic Yvan, Zrenner Eberhart, Paquet-Durand Francois. 2016. Scientific reports. 6: 39537 -
Oncolytic adenoviruses coated with MHC-I tumor epitopes increase the antitumor immunity and efficacy against melanoma
Capasso Cristian, Hirvinen Mari, Garofalo Mariangela, Romaniuk Dmitrii, Kuryk Lukasz, Sarvela Teea, Vitale Andrea, Antopolsky Maxim, Magarkar Aniket, Viitala Tapani, Suutari Teemu, Bunker Alex, Yliperttula Marjo, Urtti Arto, Cerullo Vincenzo. 2016. Oncoimmunology. 5: e1105429 -
Photothermally Triggered Lipid Bilayer Phase Transition and Drug Release from Gold Nanorod and Indocyanine Green Encapsulated Liposomes
Viitala Lauri, Pajari Saija, Lajunen Tatu, Kontturi Leena-Stiina, Laaksonen Timo, Kuosmanen Päivi, Viitala Tapani, Urtti Arto, Murtomäki Lasse. 2016. Langmuir. 32: 4554-4563 -
Predictive Modeling of Ocular Pharmacokinetics and Adverse Effects
Ghemtio Leo, Xhaard Henri, Urtti Arto, Kidron Heidi. 2016. Current pharmaceutical design. 22: 6928-6934 -
Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models
Toivonen Sanna, Malinen Melina M, Küblbeck Jenni, Petsalo Aleksanteri, Urtti Arto, Honkakoski Paavo, Otonkoski Timo. 2016. Tissue engineering. 22: 971-984 -
Cellular and Nuclear Concentrations and Cytotoxicity of Anticancer Drug Doxorubicin and its Liposomal Formulations in Two Cancer Cell Types
Soininen Suvi K, Vellonen Kati-Sisko, Koivisto Heta, Urtti Arto, Ruponen Marika. 2015. Publications of the University of Eastern Finland. Reports and studies in health sciences -
Exploring the structure-activity relationships of ABCC2 modulators using a screening approach
Wissel Gloria, Kudryavtsev Pavel, Ghemtio Leo, Tammela Päivi, Wipf Peter, Yliperttula Marjo, Finel Moshe, Urtti Arto, Kidron Heidi, Xhaard Henri. 2015. Bioorganic and medicinal chemistry. 23: 3513-3525 -
Intravitreal clearance and volume of distribution of compounds in rabbits: In silico prediction and pharmacokinetic simulations for drug development
Del Amo Eva M, Vellonen Kati-Sisko, Kidron Heidi, Urtti Arto. 2015. European journal of pharmaceutics and biopharmaceutics. 95: 215-226 -
Light induced cytosolic drug delivery from liposomes with gold nanoparticles
Lajunen Tatu, Viitala Lauri, Kontturi Leena-Stiina, Laaksonen Timo, Liang Huamin, Vuorimaa-Laukkanen Elina, Viitala Tapani, Le Guével Xavier, Yliperttula Marjo, Murtomäki Lasse, Urtti Arto. 2015. Journal of controlled release. 203: 85-98 -
Modulatory effect of human plasma on the internal nanostructure and size characteristics of liquid-crystalline nanocarriers
Mat Azmi Intan D, Wu Linping, Wibroe Peter P, Nilsson Christa, Østergaard Jesper, Stürup Stefan, Gammelgaard Bente, Urtti Arto, Moghimi Seyed M, Yaghmur Anan. 2015. Langmuir. 31: 5042-5049 -
Novel biodegradable polyesteramide microspheres for controlled drug delivery in Ophthalmology
Andrés-Guerrero Vanessa, Zong Mengmeng, Ramsay Eva, Rojas Blanca, Sarkhel Sanjay, Gallego Beatriz, de Hoz Rosa, Ramírez Ana I, Salazar Juan J, Triviño Alberto, Ramírez José M, Del Amo Eva M, Cameron Neil, de-Las-Heras Beatriz, Urtti Arto, Mihov George, Dias Aylvin, Herrero-Vanrell Rocío. 2015. Journal of controlled release. 211: 105-117 -
Prediction of ocular drug distribution from systemic blood circulation
Vellonen Kati-Sisko, Soini Esa-Matti, del Amo Eva M, Urtti Arto. 2015. Molecular pharmaceutics. 13 (2016): 2906-2911 -
Rabbit as an animal model for intravitreal pharmacokinetics: Clinical predictability and quality of the published data
Del Amo Eva M, Urtti Arto. 2015. Experimental eye research. 137: 111-124 -
Undefined role of mucus as a barrier in ocular drug delivery
Ruponen Marika, Urtti Arto. 2015. European journal of pharmaceutics and biopharmaceutics. 96: 442-446 -
A critical assessment of in vitro tissue models for ADME and drug delivery
Vellonen Kati-Sisko, Malinen Melina, Mannermaa Eliisa, Subrizi Astrid, Toropainen Elisa, Lou Yan-Ru, Kidron Heidi, Yliperttula Marjo, Urtti Arto. 2014. Journal of controlled release. 190: 94-114 -
An injectable, in situ forming type II collagen/hyaluronic acid hydrogel vehicle for chondrocyte delivery in cartilage tissue engineering
Kontturi Leena-Stiina, Järvinen Elina, Muhonen Virpi, Collin Estelle C, Pandit Abhay S, Kiviranta Ilkka, Yliperttula Marjo, Urtti Arto. 2014. Drug delivery and translational research. 4: 149-158 -
Codon optimization and factorial screening for enhanced soluble expression of human ciliary neurotrophic factor in Escherichia coli
Itkonen Jaakko M, Urtti Arto, Bird Louise E, Sarkhel Sanjay. 2014. Bmc biotechnology. 14: 92 -
Differentiation of liver progenitor cell line to functional organotypic cultures in 3D nanofibrillar cellulose and hyaluronan-gelatin hydrogels
Malinen Melina M, Kanninen Liisa K, Corlu Anne, Isoniemi Helena M, Lou Yan-Ru, Yliperttula Marjo L, Urtti Arto O. 2014. Biomaterials. 35: 5110-5121 -
Encapsulated cells for long-term secretion of soluble VEGF receptor 1: material optimization and simulation of ocular drug response
Kontturi Leena-Stiina, Collin Estelle C, Murtomäki Lasse, Pandit Abhay S, Yliperttula Marjo, Urtti Arto. 2014. European journal of pharmaceutics and biopharmaceutics. 2015; 95: 387-397 -
Formulation and Stability of Cytokine Therapeutics
Lipiäinen Tiina, Peltoniemi Marikki, Sarkhel Sanjay, Yrjönen Teijo, Vuorela Heikki, Urtti Arto, Juppo Anne. 2014. Journal of pharmaceutical sciences. 2015; 104: 307-326 -
High-throughput in vitro drug release and pharmacokinetic simulation as a tool for drug delivery system development: Application to intravitreal ocular administration
Sarkhel Sanjay, Ramsay Eva, Kontturi Leena-Stiina, Peltoniemi Jonne, Urtti Arto. 2014. International journal of pharmaceutics. 477: 469-475 -
Naphthoquinones and Anthraquinones: Chemical, Analytical, and Biological Overview
El-Najjar Nahed, Gali-Muhtasib Hala, Vuorela Pia, Urtti Arto, Vuorela Heikki. Teoksessa: Meyers, R.A. (toim.)(toim.) , 2014. Encyclopedia of Analytical Chemistry. s. 1-16. John Wiley & Sons -
Oxidative Stress Protection by Exogenous Delivery of rhHsp70 Chaperone to the Retinal Pigment Epithelium (RPE), a Possible Therapeutic Strategy Against RPE Degeneration
Subrizi Astrid, Toropainen Elisa, Ramsay Eva, Airaksinen Anu J, Kaarniranta Kai, Urtti Arto. 2014. Pharmaceutical research. 2015; 32: 211-221 -
PEGylation of phytantriol-based lyotropic liquid crystalline particles - the effect of lipid composition, PEG chain length, and temperature on the internal nanostructure
Nilsson Christa, Østergaard Jesper, Weng Larsen Susan, Larsen Claus, Urtti Arto, Yaghmur Anan. 2014. Langmuir. 30: 6398-6407 -
Pharmacokinetic simulations to explore dissolution criteria of BCS I and III biowaivers with and without MDR-1 efflux transporter
Kortejärvi H, Malkki J, Shawahna R, Scherrmann JM, Urtti A, Yliperttula M. 2014. European journal of pharmaceutical sciences. 61: 18-26 -
Poor Cellular Internalization of Caelyx® Limits its Toxic Effect Compared with Free Doxorubicin and pH-sensitive Liposomes Encapsulating Doxorubicin
Soininen Suvi K, Koivisto Heta, Vellonen Kati-Sisko, Urtti Arto, Ruponen Marika. 2014. - -
Quantitative Analysis of Intracellular Pharmacokinetics of Doxorubicin and its Liposomal Formulations and A Computational Model of the Intracellular PK/PD Relationship
Soininen Suvi K, Välitalo Pyry, Koivisto Heta, Heikkinen Aki, Ranta Veli-Pekka, Vellonen Kati-Sisko, Urtti Arto, Ruponen Marika. 2014. Publications of the University of Eastern Finland. Reports and studies in health sciences -
Technetium-99m-labeled nanofibrillar cellulose hydrogel for in vivo drug release
Laurén Patrick, Lou Yan-Ru, Raki Mari, Urtti Arto, Bergström Kim, Yliperttula Marjo. 2014. European journal of pharmaceutical sciences. 65: 79-88 -
The use of nanofibrillar cellulose hydrogel as a flexible three-dimensional model to culture human pluripotent stem cells
Lou Yan-Ru, Kanninen Liisa, Kuisma Tytti, Niklander Johanna, Noon Luke A, Burks Dedorah, Urtti Arto, Yliperttula Marjo. 2014. Stem cells and development. 23: 380-392 -
Topical drug delivery to retinal pigment epithelium with microfluidizer produced small liposomes
Lajunen T, Hisazumi K, Kanazawa T, Okada H, Seta Y, Yliperttula M, Urtti A, Takashima Y. 2014. European journal of pharmaceutical sciences. 62: 23-32 -
Xeno-free chondrogenesis of bone marrow mesenchymal stromal cells: towards clinical-grade chondrocyte production
Skog Maria, Muhonen Virpi, Nystedt Johanna, Narcisi Roberto, Kontturi Leena-Stiina, Urtti Arto, Korhonen Matti, van Osch Gerjo J, Kiviranta Ilkka. 2014. Cytotechnology. 2015; 67: 905-919 -
Challenges of using in vitro data for modeling p-glycoprotein efflux in the blood-brain barrier
Sjöstedt Noora, Kortejärvi Hanna, Kidron Heidi, Vellonen Kati-Sisko, Urtti Arto, Yliperttula Marjo. 2013. Pharmaceutical research. 2014:31: 1-19 -
Tutkijakoulutuksen muutoksia
Urtti Arto, Männistö Pekka T, Honkakoski Paavo. Teoksessa: Ahonen R, Laitinen K, Lapinjoki S, Mensalo P, Ranta V-P, Ylikangas H (toim).(toim.) , 2013. Muutosten vuosikymmen : Itä-Suomen yliopiston farmasian laitos 40 vuotta. s. 58-59. -
Corneal epithelium as a platform for secretion of transgene products after transfection with liposomal gene eyedrops
Toropainen E, Hornof M, Kaarniranta K, Johansson P, Urtti A. 2007. Journal of gene medicine. 9: 208-216 -
Computational prediction of oral drug absorption based on absorption rate constants in humans
Linnankoski J, Mäkelä JM, Ranta V-P, Urtti A, Yliperttula M. 2006. Journal of medicinal chemistry. 49: 3674-3681 -
Epidermal cell culture model with tight stratum corneum as a tool for dermal gene delivery studies
Paasonen L, Korhonen M, Yliperttula M, Urtti A. 2006. International journal of pharmaceutics. 307: 188-193 -
Freeze-drying of cationic polymer DNA complexes enables their long-term storage and reverse transfection of post-mitotic cells
Reinisalo M, Urtti A, Honkakoski P. 2006. Journal of controlled release. 110: 437-443 -
Microemulsions in topical drug delivery
Pappinen S, Urtti A. Teoksessa: Smith EW, Maibach HI(toim.) , 2006. Percutaneous Penetration Enhancers. 2nd ed.. s. 109-116. CRC Press, Taylor & Francis Group -
Cell culture models of the ocular barriers
Hornof M, Toropainen E, Urtti A. 2005. European journal of pharmaceutics and biopharmaceutics. 60: 207-225 -
Long-lasting secretion of transgene product from differentiated and filter-grown retinal pigment epithelial cells after nonviral gene transfer
Mannermaa E, Rönkkö S, Ruponen M, Reinisalo M, Urtti A. 2005. Current eye research. 30: 345-353 -
Nonviral gene delivery methods in cardiovascular diseases
Ruponen M, Hyvönen Z, Urtti A, Ylä-Herttuala S. Teoksessa: Fennell JP, Baker AH(toim.) , 2005. Hypertension. Methods and Protocols. s. 315-328. Humana Press -
Permeability of retinal pigment epithelium: Effects of permeant molecular weight and lipophilicity
Pitkänen L, Ranta V-P, Moilanen H, Urtti A. 2005. Investigative ophthalmology and visual science. 46: 641-646 -
Rat epidermal keratinocyte organotypic culture (ROC) as a model for chemically induced skin irritation testing
Pappinen S, Pasonen-Seppänen S, Suhonen M, Tammi R, Urtti A. 2005. Toxicology and applied pharmacology. 208: 233-241 -
Surface plasmon resonance spectroscopy as a tool to study polyplex-glycoaminoglycan interactions
Dubruel P, Urtti A, Schacht E. 2005. Macromolecular rapid communications. 26: 992-997 -
The role of cell cycle on polyplex-mediated gene transfer into a retinal pigment epithelial cell line
Männistö M, Rönkkö S, Mättö M, Honkakoski P, Hyttinen M, Pelkonen J, Urtti A. 2005. Journal of gene medicine. 7: 466-476 -
Cell-surface glycosaminoglycans inhibit cation-mediated gene transfer
Ruponen M, Honkakoski P, Tammi M, Urtti A. 2004. Journal of gene medicine. 6: 405-414 -
Determination of the degree of substitution of acetylated starch by hydrolysis, 1H NMR and TGA/IR
Elomaa M, Asplund T, Soininen P, Laatikainen R, Peltonen S, Hyvärinen S, Urtti A. 2004. Carbohydrate polymers. : 261-267 -
Dioleoyl phosphatidylethanolamine and PEG-lipid conjugates modify DNA delivery mediated by 1,4-dihydropyridine amphiphiles
Hyvönen Z, Rönkkö S, Toppinen M-R, Jääskeläinen I, Plotniece A, Urtti A. 2004. Journal of controlled release. 99: 177-190 -
Drug permeation in biomembranes in vitro and in silico prediction and influence of physicochemical properties
Mälkiä A, Murtomäki L, Urtti A, Kontturi K. 2004. European journal of pharmaceutical sciences. 23: 13-47 -
Effect of cell-surface glycosaminoglycans on cationic carrier combined with low-MW PEI-mediated gene transfection
Lampela P, Soininen P, Puttonen KA, Ruponen M, Urtti A, Männistö PT, Raasmaja A. 2004. International journal of pharmaceutics. 284: 43-52 -
Electrochemical and calorimetric study of oligonucleotide complexation with cetylpyridinium chloride
Hakkarainen S, Kontturi A-K, Kontturi K, Urtti A. 2004. European journal of pharmaceutical sciences. 23: 371-377 -
Evaluation of novel starch acetate-diltiazem controlled release tablets in healthy human volunteers
Korhonen O, Kanerva H, Vidgren M, Urtti A, Ketolainen J. 2004. Journal of controlled release. 95: 515-520 -
Neural retina limits the nonviral gene transfer to retinal pigment epithelium in an vitro bovine eye model
Pitkänen L, Pelkonen J, Ruponen M, Rönkkö S, Urtti A. 2004. AAPS journal. 6: 1-9 -
Requirements for delivery of active antisense oligonucleotides into cells with lipid carriers
Jääskeläinen I, Lappalainen K, Honkakoski P, Urtti A. 2004. Methods in enzymology. 387: 210-230 -
Starch acetate microparticles for drug delivery into retinal pigment epithelium - in vitro study
Tuovinen L, Ruhanen E, Kinnarinen T, Rönkkö S, Pelkonen J, Urtti A, Peltonen S, Järvinen K. 2004. Journal of controlled release. 98: 407-413 -
Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity
Vellonen K-S, Honkakoski P, Urtti A. 2004. European journal of pharmaceutical sciences. 23: 181-188 -
Synergism in gene delivery by small PEIs and three different nonviral vectors
Lampela P, Soininen P, Urtti A, Männistö PT, Raasmaja A. 2004. International journal of pharmaceutics. 270: 175-184 -
Different synergistic roles of small polyethylenimine and Dosper in gene delivery
Lampela P, Elomaa M, Ruponen M, Urtti A, Männistö PT, Raasmaja A. 2003. Journal of controlled release. 88: 173-183 -
Elektrodianturi
Valjakka A, Urtti A, Ahonen J. 2003. -
Epidermal cell culture model derived from rat keratinocytes with permeability characteristics comparable to human cadaver skin
Suhonen TM, Pasonen-Seppänen S, Kirjavainen M, Tammi M, Tammi R, Urtti A. 2003. European journal of pharmaceutical sciences. 20: 107-113 -
Extracellular and intracellular barriers in non-viral gene delivery
Ruponen M, Honkakoski P, Rönkkö S, Pelkonen J, Tammi M, Urtti A. 2003. Journal of controlled release. 93: 213-217 -
Microemulsions for topical delivery of estradiol
Peltola S, Saarinen-Savolainen P, Kiesvaara J, Suhonen TM, Urtti A. 2003. International journal of pharmaceutics. 254: 99-107 -
Näköstimulaatiolaite
Valjakka A, Urtti A, Ahonen J. 2003. -
Ocular pharmacokinetic modeling using corneal absorption and desorption rates from in vitro permeation experiments with cultured corneal epithelial cells
Ranta V-P, Laavola M, Toropainen E, Vellonen K-S, Talvitie A, Urtti A. 2003. Pharmaceutical research. 20: 1409-1416 -
Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model
Toropainen E, Ranta V-P, Vellonen K-S, Palmgrén J, Talvitie A, Laavola M, Suhonen P, Hämäläinen KM, Auriola S, Urtti A. 2003. European journal of pharmaceutical sciences. 20: 99-106 -
Poly-L-glutamic acid derivatives as multifunctional vectors for gene delivery. Part B. Biological evaluation
Dubruel P, Dekie L, Christiaens B, Vanloo B, Rosseneu M, Van De Kerckhove J, Mannisto M, Urtti A, Schacht E. 2003. Biomacromolecules. 4: 1177-1183 -
Retina-specific gene expression and improved DNA transfection in WERI-Rb1 retinoblastoma cells
Reinisalo M, Urtti A, Honkakoski P. 2003. BIOCHIMICA ET BIOPHYSICA ACTA - GENE STRUCTURE AND EXPRESSION. 1628: 169-176 -
Retinal disease models for development of drug and gene therapies
Pitkänen L, Salminen L, Urtti A. Teoksessa: Mitra AK(toim.) , 2003. Ophthalmic Drug Delivery Systems. s. 515-533. Marcel Dekker -
Vitreous is a barrier in nonviral gene transfer by cationic lipids and polymers
Pitkänen L, Ruponen M, Nieminen J, Urtti A. 2003. Pharmaceutical research. 20: 576-583 -
Cell membranes as barriers for the use of antisense therapeutic agents
Jääskeläinen I, Urtti A. 2002. Mini-reviews in medicinal chemistry. 2: 307-318 -
Conformation and ion-binding of oligonucleotides
Kontturi A-K, Kontturi K, Urtti A. 2002. European journal of pharmaceutical sciences. 15: 379-385 -
Effect of the enzyme inhibitor, phenylmethylsulfonyl fluoride, on the IOP profiles of topical anandamides
Laine K, Järvinen K, Pate DW, Urtti A, Järvinen T. 2002. Investigative ophthalmology and visual science. 43: 393-397 -
Extracellular and intracellular factors influencing gene transfection mediated by 1,4-dihydropyridine amphiphiles
Hyvönen Z, Ruponen M, Rönkkö S, Suhonen P, Urtti A. 2002. European journal of pharmaceutical sciences. 15: 449-460 -
In vitro delivery of antisense oligonucleotides
Jääskeläinen I, Honkakoski P, Urtti A. 2002. Cellular and molecular biology letters. 7: 236-237 -
Liquid chromatographic-electrospray ionization mass spectrometric analysis of neutral and charged polyethylene glycols
Palmgrén JJ, Toropainen E, Auriola S, Urtti A. 2002. Journal of chromatography a. 976: 165-170 -
Menetelmä farmaseuttisen koostumuksen valmistamiseksi
Järvinen T, Järvinen K, Urtti A, Pate DW. 2002. -
Simultaneous determination of eight beta-blockers by gradient high-performance liquid chromatography with combined ultraviolet and fluorescence detection in corneal permeability studies in vitro
Ranta V-P, Toropainen E, Talvitie A, Auriola S, Urtti A. 2002. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 772: 81-87 -
Structure-activity relationships of poly(L-lysines): effects of pegylation and molecular shape on physicochemical and biological properties in gene delivery
Männistö M, Vanderkerken S, Toncheva V, Elomaa M, Ruponen M, Schacht E, Urtti A. 2002. Journal of controlled release. 83: 169-182 -
Uusi genomitieto lääkekehityksen ja lääkehoidon avuksi
Urtti A. 2002. Dosis. 18: 154-160 -
A novel drug-regulated gene expression system based on the nuclear receptor constitutive androstane receptor (CAR)
Honkakoski P, Jääskeläinen I, Kortelahti M, Urtti A. 2001. Pharmaceutical research. 18: 146-150 -
Culture model of human corneal epithelium for prediction of ocular drug absorption
Toropainen E, Ranta V-P, Talvitie A, Suhonen P, Urtti A. 2001. Investigative ophthalmology and visual science. 42: 2942-2948 -
Extracellular glycosaminoglycans modify cellular trafficking of lipoplexes and polyplexes
Ruponen M, Rönkkö S, Honkakoski P, Pelkonen J, Tammi M, Urtti A. 2001. Journal of biological chemistry. 276: 33875-33880 -
Formation of permeability barrier in epidermal organotypic culture for studies on drug transport
Pasonen-Seppänen S, Suhonen TM, Kirjavainen M, Miettinen M, Urtti A, Tammi M, Tammi R. 2001. Journal of investigative dermatology -
Genomic structure of proton-coupled oligopeptide transporter hPEPT1 and pH-sensing regulatory splice variant
Urtti A, Sadée W, Johns SJ. 2001. AAPS journal. 3: -
Lipid bilayers in cells: implications in drug and gene delivery
Suhonen TM, Suhonen P, Urtti A. Teoksessa: Volkov AG(toim.) , 2001. Liquid Interfaces in Chemical, Biological, and Pharmaceutical Applications. s. 807-844. Markel Dekker -
Vitamin C enhances differentation of a continuous keratinocyte cell line (REK) into epidermis with normal stratum corneum ultrastructure and functional permeability barrier
Pasonen-Seppänen S, Suhonen TM, Kirjavainen M, Suihko E, Urtti A, Miettinen M, Hyttinen M, Tammi M, Tammi R. 2001. Histochemistry and cell biology. 116: 287-297 -
A lipid carrier with a membrane active component and a small complex size are required for efficient cellular delivery of anti-sense phosphorothioate oligonucleotides
Jääskeläinen I, Peltola S, Honkakoski P, Mönkkönen J, Urtti A. 2000. European journal of pharmaceutical sciences. 10: 187-193 -
Controlled transdermal iontophoresis by ion-exchange fiber
Jaskari T, Vuorio M, Kontturi K, Urtti A, Manzanares JA, Hirvonen J. 2000. Journal of controlled release. 67: 179-190 -
Enzymatic and permeation barrier of [D-Ala2]-met-enkephalinamide in the anterior membranes of the albino rabbit eye
Hämäläinen KM, Ranta V-P, Auriola S, Urtti A. 2000. European journal of pharmaceutical sciences. 9: 265-270 -
Gene delivery and expression in human retinal pigment epithelial cells: effects of synthetic carriers, serum, extracellular matrix and viral promoters
Urtti A, Polansky J, Lui GM, Szoka FC. 2000. Journal of drug targeting. 7: 413-421 -
Influence of lipids on the mannitol flux during transdermal iontophoresis in vitro
Kirjavainen M, Urtti A, Mönkkönen J, Hirvonen J. 2000. European journal of pharmaceutical sciences. 10: 97-102 -
Novel cationic amphiphilic 1,4-dihydropyridine derivatives for DNA delivery
Hyvönen Z, Plotniece A, Reine I, Chekavichus B, Duburs G, Urtti A. 2000. Biochimica et biophysica acta: biomembranes. 1509: 451-466 -
Synthesis and evaluation of poly(ethylene glycol)-polylysine block copolymers as carriers for gene delivery
Vanderkerken S, Vanheede T, Toncheva V, Schacht E, Wolfert MA, Seymour L, Urtti A. 2000. Journal of bioactive and compatible polymers. 15: 115-138 -
Transdermal delivery of levosimendan
Valjakka-Koskela R, Hirvonen J, Mönkkönen J, Kiesvaara J, Antila S, Lehtonen L, Urtti A. 2000. European journal of pharmaceutical sciences. 11: 343-350 -
Water-activated, pH-controlled patch in transdermal administration of timolol: I. Preclinical tests
Sutinen R, Paronen P, Urtti A. 2000. European journal of pharmaceutical sciences. 11: 19-24 -
Water-activated, pH-controlled patch in transdermal administration of timolol: II. Drug absorption and skin irritation
Sutinen R, Paronen P, Saano V, Urtti A. 2000. European journal of pharmaceutical sciences. 11: 25-31 -
Anandamide analog compositions and method of treating intraocular hypertension using same
Pate DW, Jarvinen T, Jarvinen K, Urtti A. 1999. -
Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations
Suhonen TM, Bouwstra JA, Urtti A. 1999. Journal of controlled release. 59: 149-161 -
Contrasting effects of alendronate and clodronate on RAW 264 macrophages: the role of a bisphosphonate metabolite
Makkonen N, Salminen A, Rogers MJ, Frith JC, Urtti A, Azhayeva E, Mönkkönen J. 1999. European journal of pharmaceutical sciences. 8: 109-118 -
Drug release from cation exchange membrane in rabbit eye
Tarvainen T, Svarfvar B, Sääskilahti M, Urtii A, Paronen P, Järvinen K. 1999. Journal of ocular pharmacology and therapeutics. 15: 497-504 -
Efficient adventitial gene delivery to rabbit carotid artery with cationic polymer-plasmid complexes
Turunen MP, Hiltunen MO, Ruponen M, Virkamäki L, Szoka FC Jr, Urtti A, Ylä-Herttuala S. 1999. Gene therapy. 6: 6-11 -
Influence of ionic strength on drug adsorption onto and release from a poly(acrylic acid) grafted poly(vinylidene fluoride) membrane
Åkerman S, Svarfvar B, Kontturi K, Näsman J, Urtti A, Paronen P, Järvinen K. 1999. International journal of pharmaceutics. 178: 67-75 -
Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies
Ruponen M, Ylä-Herttuala S, Urtti A. 1999. Biochimica et biophysica acta: international journal of biochemistry and biophysics. 1415: 331-341 -
Liposome-skin interactions and their effects on the skin permeation of drugs
Kirjavainen M, Urtti A, Valjakka-Koskela R, Kiesvaara J, Mönkkönen J. 1999. European journal of pharmaceutical sciences. 7: 279-286 -
Peptide-oligonucleotide phosphorothioate conjugates with membrane translocation and nuclear localization properties
Antopolsky M, Azhayeva E, Tengvall U, Auriola S, Jääskeläinen I, Rönkkö S, Honkakoski P, Urtti A, Lönnberg H, Azhayev A. 1999. Bioconjugate chemistry. 10: 598-606 -
Pharmacokinetics and safety of deramciclane during multiple oral dosing
Kanerva H, Kilkku O, Helminen A, Rouru J, Scheinin M, Huupponen R, Klebovich I, Drabant S, Urtti A. 1999. International journal of clinical pharmacology and therapeutics. 37: 589-597 -
Phospholipids affect stratum corneum lipid bilayer fluidity and drug partitioning into the bilayers
Kirjavainen M, Mönkkönen J, Saukkosaari M, Valjakka-Koskela R, Kiesvaara J, Urtti A. 1999. Journal of controlled release. 58: 207-214 -
The single dose pharmacokinetics and safety of deramciclane in healthy male volunteers
Kanerva H, Kilkku O, Heinonen E, Helminen A, Rouru J, Tarpila S, Scheinin M, Huupponen R, Klebovich I, Drabant S, Urtti A. 1999. Biopharmaceutics and drug disposition. 20: 327-334 -
Comparative pharmacokinetics of deramciclane in rat, dog, rabbit and man after the administration of a single oral dose of 3 mg kg -1
Klebovich I, Kanerva H, Bojti E, Urtti A, Drabant S. 1998. PHARMACY AND PHARMACOLOGY COMMUNICATIONS. 4: 129-136 -
Comparative pharmacokinetics of deramciclane in various species (rat, dog, rabbit, human) after the administration of a single oral dose of 3 mg kg -1
Klebovich I, Kanerva H, Bojti E, Urtti A, Drabant S. 1998. PHARMACY AND PHARMACOLOGY COMMUNICATIONS. 4: 1-9 -
Different absorption profiles of deramciclane in man and in dog
Kanerva H, Klebovich I, Drabant S, Urtti A, Nevalainen T. 1998. Journal of pharmacy and pharmacology. 50: 1087-1093 -
Different effects of pH on the permeation of pilocarpine and pilocarpine prodrugs across the isolated rabbit cornea
Suhonen P, Järvinen T, Koivisto S, Urtti A. 1998. European journal of pharmaceutical sciences. 6: 169-176 -
Drug permeation through a temperature-sensitive poly(N-isopropylacrylamide) grafted poly(vinylidene fluoride) membrane
Åkerman S, Viinikka P, Svarfvar B, Putkonen K, Järvinen K, Kontturi K, Näsman J, Urtti A, Paronen P. 1998. International journal of pharmaceutics. 164: 29-36 -
Effect of the CB1 receptor antagonist, SR141716A, on cannabinoid-induced ocular hypotension in normotensive rabbits
Pate DW, Järvinen K, Urtti A, Mahadevan V, Järvinen T. 1998. Life sciences. 63: 2181-2188 -
Enhancement of percutaneous absorption of naproxen by phospholipids
Valjakka-Koskela R, Kirjavainen M, Mönkkönen J, Urtti A, Kiesvaara J. 1998. International journal of pharmaceutics. 175: 225-230 -
Evaluation of cytotoxicity of various ophthalmic drugs, eye drop excipients and cyclodextrins in an immortalized human corneal epithelial cell line
Saarinen-Savolainen P, Järvinen T, Araki-Sasaki K, Watanabe H, Urtti A. 1998. Pharmaceutical research. 15: 1275-1280 -
Geenilääkkeet tulevat
Urtti A. 1998. Dosis. 14: 183-190 -
Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites, and enzyme inhibitors using combined ultraviolet and electrochemical detection. II. Application to ocular permeability studies in vitro
Ranta V-P, Hämäläinen KM, Auriola S, Urtti A. 1998. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 709: 1-10 -
Lipid fusion in oligonucleotide and gene delivery with cationic lipids
Mönkkönen J, Urtti A. 1998. Advanced drug delivery reviews. 34: 37-49 -
Pharmacokinetics of deramciclane in dogs after single oral and intravenous dosing and multiple oral dosing
Kanerva H, Huuskonen H, Alhonen-Raatesalmi A, Nevalainen T, Urtti A. 1998. Biopharmaceutics and drug disposition. 19: 531-539 -
Physicochemical and morphological properties of complexes made of cationic liposomes and oligonucleotides
Jääskeläinen I, Sternberg B, Mönkkönen J, Urtti A. 1998. International journal of pharmaceutics. 167: 191-203 -
Roles of acid/base nature and molecular weight in drug release from matrices of gelfoam and monoisopropyl ester of poly(vinyl methyl ether-maleic anhydride)
Hämäläinen KM, Määttä E, Piirainen H, Sarkola M, Väisänen A, Ranta V-P, Urtti A. 1998. Journal of controlled release. 56: 273-283 -
Transport of drugs across porous ion exchange membranes
Åkerman S, Viinikka P, Svarfvar B, Järvinen K, Kontturi K, Näsman J, Urtti A, Paronen P. 1998. Journal of controlled release. 50: 153-166 -
Analysis of oligonucleotides with capillary electrophoresis electrospray mass spectrometry
Auriola S, Thibault P, Koivuniemi A, Jääskeläinen I, Urtti A. Teoksessa: (toim.) , 1997. The 45th ASMS Conference on Mass Spectrometry and Allied Topics. Proceedings.. s. 651. -
Anandamides useful for the treatment of intraocular hypertension, ophthalmic compositions containing the same and methods of use of the same
Pate DW, Jarvinen T, Jarvinen K, Urtti A. 1997. -
Beta-cyclodextrin derivatives (2-HP-beta-CD, SBE4-beta-CD) decrease the amphiphilicity and membrane perturbing effects of pilocarpine prodrugs
Saarinen-Savolainen P, Urtti A, Jarho P, Järvinen T. 1997. European journal of pharmaceutical sciences. 5: 89-96 -
Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera
Hämäläinen KM, Kananen K, Auriola S, Kontturi K, Urtti A. 1997. Investigative ophthalmology and visual science. 38: 627-634 -
Composition for pH dependent controlled release of active ingredients and method for producing it
Urtti AO, Peltonen SH, Paronen TP, Nakari LJ, Vuorenpää J-E. 1997. -
Effects of Topical alpha-substituted anandamides on intraocular pressure in normotensive rabbits
Pate DW, Järvinen K, Urtti A, Jarho P, Mahadevan V, Järvinen T. 1997. Pharmaceutical research. 14: 1738-1743 -
Effects of phospholipids on the percutaneous penetration of sotalol and propranolol
Kirjavainen M, Urtti A, Mönkkönen J. Teoksessa: Couvreur P, Duchêne D, Green P, Junginger HE(toim.) , 1997. Transdermal Administration, a Case Study, Iontophoresis. European Symposium. s. 221-225. Éditions de Santé -
Esterové deriváty kyseliny bispilokarpové, zpusob jejich prípravy a farmaceuticky prostredek je obsahující
Järvinen T, Peura P, Suhonen P, Urtti A, Hanhijärvi H, Pohjala E. 1997. -
Estimation of pore size and pore density of biomembranes from permeability measurements of polyethylene glycols using an effusion-like approach
Hämäläinen KM, Kontturi K, Auriola S, Murtomäki L, Urtti A. 1997. Journal of controlled release. 49: 97-104 -
Farmasia ja tiedepolitiikan uudet tuulet
Urtti A. 1997. Dosis -
Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites and enzyme inhibitors using combined ultraviolet and electrochemical detection. I. Optimization of separation and detection
Ranta V-P, Urtti A, Auriola S. 1997. Journal of chromatography a. 766: 85-97 -
Inhibitory properties of double helix forming circular oligonucleotides
Azhayeva E, Azhayev A, Auriola S, Tengvall U, Urtti A, Lönnberg H. 1997. Nucleic acids research. 25: 4954-4961 -
Menetelmä farmaseuttisesti käyttökelpoisten pilokarpiinijohdannaisten valmistamiseksi
Järvinen T, Peura P, Suhonen P, Urtti A, Hanhijärvi H, Pohjala E. 1997. -
Menetelmä farmaseuttisesti käyttökelpoisten pilokarpiinijohdannaisten valmistamiseksi
Järvinen T, Peura P, Suhonen P, Urtti A, Hanhijärvi H, Pohjala E. 1997. -
Menetelmä uusien, farmakologisesti käyttökelpoisten bispilokarpiinihapon esterijohdannaisten valmistamiseksi
Järvinen T, Peura P, Suhonen P, Urtti A, Hanhijärvi H, Pohjala E. 1997. -
Method for evaluating drug release from liposomes in sink conditions
Saarinen-Savolainen P, Järvinen T, Taipale H, Urtti A. 1997. International journal of pharmaceutics. 159: 27-33 -
New drug release test for liposomes
Saarinen-Savolainen P, Järvinen T, Taipale H, Urtti A. Teoksessa: (toim.) , 1997. The 24th International Symposium on Controlled Release of Bioactive Materials. Proceedings. s. 1041. Controlled Release Society -
Permeation of FITC-dextrans through temperature sensitive polymer membrane
Åkerman S, Viinikka P, Svarfvar B, Putkonen K, Järvinen K, Kontturi K, Näsman J, Urtti A, Paronen P. Teoksessa: (toim.) , 1997. The 24th International Symposium on Controlled Release of Bioactive Materials. Proceedings.. s. 1039-1040. Controlled Release Society -
Starch acetate composition with modifiable properties, method for preparation and usage thereof
Paronen TP, Peltonen SH, Urtti AO, Nakari LJ. 1997. -
Starch acetates - multifunctional excipients for tabletting
Raatikainen P, Paronen P, Peltonen S, Nakari J, Urtti A. Teoksessa: (toim.) , 1997. 16th Pharmaceutical Technology Conference and Exhibition. Vol. 2.. s. 192-216. -
The use of cyclodextrins in ophthalmic formulations of dipivefrin
Jarho P, Järvinen K, Urtti A, Stella VJ, Järvinen T. 1997. International journal of pharmaceutics. 153: 225-233 -
Tilastokummajaisia
Urtti A. 1997. Dosis -
Transepidermal delivery of ß-blocking agents: evaluation of enhancer effects using stratum corneum lipid liposomes1
Suhonen TM, Pirskanen L, Räisänen M, Kosonen K, Rytting JH, Paronen P, Urtti A. 1997. Journal of controlled release. 43: 251-259 -
Tutkijakoulu tuli
Urtti A. 1997. Dosis -
Accumulation of bisphosphonates in the aorta and some other tissues of healthy and atherosclerotic rabbits
Ylitalo R, Mönkkönen J, Urtti A, Ylitalo P. 1996. Translational research. 127: 200-206 -
Amphiphilic properties of pilocarpine prodrugs
Saarinen-Savolainen P, Järvinen T, Suhonen P, Urtti A. 1996. International journal of pharmaceutics. 133: 171-178 -
Analysis of oligonucleotides by on-column transient capillary isotachophoresis and capillary electrophoresis in poly(ethylene glycol)-filled columns
Auriola S, Jääskeläinen I, Regina M, Urtti A. 1996. Analytical chemistry. 68: 3907-3911 -
Effect of cyclodextrin on the drug release from pH-controlled silicone microspheres
Sutinen R, Kekki M, Paronen P, Urtti A. Teoksessa: Couvreur P, Duchêne D, Kalles I(toim.) , 1996. European Symposium on Formulation of Poorly-Available Drugs for Oral Administration. s. 261-264. Editions de Santé -
Effects of topical anandamides on intraocular pressure in normotensive rabbits
Pate DW, Järvinen K, Urtti A, Jarho P, Fich M, Mahadevan V, Järvinen T. 1996. Life sciences. 58: 1849-1860 -
Hydroxypropyl-ß-cyclodextrin increases aqueous solubility and stability of anandamide
Jarho P, Urtti A, Järvinen K, Pate DW, Järvinen T. 1996. Life sciences. 58: 181-185 -
Increase in aqueous solubility, stability and in vitro corneal permeability of anandamide by hydroxypropyl-ß-cyclodextrin
Jarho P, Urtti A, Pate DW, Suhonen P, Järvinen T. 1996. International journal of pharmaceutics. 137: 209-216 -
Interaction of liposomes with human skin in vitro - the influence of lipid composition and structure
Kirjavainen M, Urtti A, Jääskeläinen I, Suhonen TM, Paronen P, Valjakka-Koskela R, Kiesvaara J, Mönkkönen J. 1996. Biochimica et biophysica acta: international journal of biochemistry and biophysics. 1304: 179-189 -
Modified ß-cyclodextrin (SBE7-ß-CyD) with viscous vehicle improves the ocular delivery and tolerability of pilocarpine prodrug in rabbits
Jarho P, Järvinen K, Urtti A, Stella VJ, Järvinen T. 1996. Journal of pharmacy and pharmacology. 48: 263-269 -
Ne fuusiot
Urtti A. 1996. Dosis -
Novel pilocarpine derivatives and process for their preparation
Jarvinen T, Peura P, Suhonen P, Urtti A, Hanhijarvi H, Pohjala E. 1996. -
Oppia ikä kaikki
Urtti A. 1996. Dosis -
Peroral drug delivery system
Urtti AO, Sutinen MR, Paronen TP. 1996. -
Rate control of ocular pilocarpine delivery with bispilocarpic acid diesters
Suhonen P, Järvinen T, Lehmussaari K, Reunamäki T, Urtti A. 1996. International journal of pharmaceutics. 127: 85-94 -
The effect of SBE7-ß-CD with viscous vehicle on ocular delivery of pilocarpine prodrug in rabbits
Jarho P, Järvinen K, Urtti A, Stella VJ, Järvinen T. Teoksessa: Szejtli J, Szente L(toim.) , 1996. Proceedings of the Eighth International Symposium on Cyclodextrons. s. 399-402. Kluwer -
The effects of HP-ß-CD on aqueous solubility, stability and in vitro corneal penetration of anandamide
Jarho P, Urtti A, Pate DW, Suhonen P, Järvinen T. Teoksessa: Szejtli J, Szente L(toim.) , 1996. Proceedings of the Eight International Symposium on Cyclodextrons. s. 395-398. Kluwer -
Bispilocarpic acid ester derivatives and process for their preparation
Järvinen T, Peura P, Suhonen P, Urtti A, Hanhijärvi H, Pohjala E. 1995. -
Buffer controlled release of indomethacin from ethylcellulose microcapsules
Tirkkonen S, Urtti A, Paronen P. 1995. International journal of pharmaceutics. 124: 219-229 -
Comparison of enzymatic hydrolysis of pilocarpine prodrugs in human plasma, rabbit cornea, and butyrylcholinesterase solutions
Järvinen T, Poikolainen M, Suhonen P, Vepsäläinen J, Alaranta S, Urtti A. 1995. Journal of pharmaceutical sciences. 84: 656-660 -
Composition for ophthalmic use
Urtti A, Järvinen T, Suhonen P, Lehmussaari K, Reunamäki T, Alaranta S, Oksala O, Pohjala E, Hanhijärvi H. 1995. -
Composition for ophthalmic use
Jaervinen T, Urtti A, Suhonen P, Peura P, Lehmussaari K, Reunamaeki T, Alaranta S, Oksala O, Pohjala E, Hanhijaervi H. 1995. -
Composition for ophthalmic use
Järvinen T, Urtti A, Suhonen P, Peura P, Lehmussaari K, Reunamäki T, Alaranta S, Oksala O, Pohjala E, Hanhijärvi H. 1995. -
Composition for ophthalmic use
Urtti A, Jaervinen T, Suhonen P, Lehmussaari K, Reunamaeki T, Alaranta S, Oksala O, Pohjala E, Hanhijaervi H. 1995. -
Effect of liposomal and free bisphosphonates on the IL-1ß, IL-6 and TNFAlfa secretion from RAW 264 cells in vitro
Pennanen N, Lapinjoki S, Urtti A, Mönkkönen J. 1995. Pharmaceutical research. 12: 916-922 -
Hydroxypropyl-ß-cyclodextrin increases the aqueous solubility and stability of pilocarpine prodrugs
Jarho P, Urtti A, Järvinen T. 1995. Pharmaceutical research. 12: 1371-1375 -
Kinetic aspects in the design of prolonged action ocular drug delivery systems
Urtti A. 1995. ADVANCES IN PHARMACEUTICAL SCIENCES. 7: 63-92 -
Komposition för topisk administration av bispilokarpinsyradiestrar till ögat i form av en vattenlösning
Urtti A, Järvinen T, Suhonen P, Peura P, Lehmussaari K, Reunamäki T, Oksala O, Alaranta S, Pohjala E, Hanhijärvi H. 1995. -
Komposition för topisk administration av bispilokarpinsyradiestrar till ögat i form av en vattenlösning
Urtti A, Järvinen T, Suhonen P, Lehmussaari K, Reunamäki T, Alaranta S, Oksala O, Pohjala E, Hanhijärvi H. 1995. -
Macrophage-like RAW 264 cell line and time-resolved fluoroimmunoassay (TRFIA) as tools in screening drug effects on cytokine secretion
Pennanen N, Lapinjoki S, Palander A, Urtti A, Mönkkönen J. 1995. INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY. 17: 475-480 -
Mechanisms of transdermal penetration enhancement
Urtti A. Teoksessa: (toim.) , 1995. Proceedings of the 22nd International Symposium on Controlled Release of Bioactive Materials. s. 115-116. -
Novel pilocarpine derivatives and process for their preparation
Järvinen T, Peura P, Suhonen P, Urtti A, Hanhijärvi H, Pohjala E. 1995. -
Novel pilocarpine derivatives and process for their preparation
Järvinen T, Peura P, Suhonen P, Urtti A, Hanhijärvi H, Pohjala E. 1995. -
Novel pilocarpine derivatives and process for their preparation
Jaervinen T, Peura P, Suhonen P, Urtti A, Hanhijaervi H, Pohjala E. 1995. -
Novel pilocarpine derivatives and process for their preparation
Järvinen T, Peura P, Suhonen P, Urtti A, Hanhijärvi H, Pohjala E. 1995. -
Novel pilocarpine derivatives and process for their preparation
Järvinen T, Peura P, Suhonen P, Urtti A, Hanhijärvi H, Pohjala E. 1995. -
Ocular absorption and irritation of pilocarpine prodrug is modified with buffer, polymer, and cyclodextrin in the eyedrop
Suhonen P, Järvinen T, Lehmussaari K, Reunamäki T, Urtti A. 1995. Pharmaceutical research. 12: 529-533 -
Ocular absorption following topical delivery
Järvinen K, Järvinen T, Urtti A. 1995. Advanced drug delivery reviews. 16: 3-19 -
Ophthalmic arachidonylethanolamide decreases intraocular pressure in normotensive rabbits
Pate DW, Järvinen K, Urtti A, Jarho P, Järvinen T. 1995. Current eye research. 14: 791-797 -
Studies on liposome formulations for intra-articular delivery of clodronate
Mönkkönen J, Liukkonen J, Taskinen M, Heath TD, Urtti A. 1995. Journal of controlled release. 35: 145-154 -
Sulfobutyl ether ß-cyclodextrin (SBE-ß-CD) in eyedrops improves the tolerability of a topically applied pilocarpine prodrug in rabbits
Järvinen T, Järvinen K, Urtti A, Thompson D, Stella VJ. 1995. Journal of ocular pharmacology and therapeutics. 11: 95-106 -
Voidaanko eläinkokeet korvata in vitro -menetelmillä silmä-ärsytystutkimuksissa
Saarinen-Savolainen P, Järvinen T, Urtti A. 1995. Dosis. 11: 69-76 -
pH-controlled silicone microspheres for controlled drug delivery
Sutinen R, Laasanen V, Paronen P, Urtti A. 1995. Journal of controlled release. 33: 163-171 -
Controlled ocular timolol delivery: systemic absorption and intraocular pressure effects in humans
Urtti A, Rouhiainen H, Kaila T, Saano V. 1994. Pharmaceutical research. 11: 1278-1282