ARTO URTTI

Contact info

Keywords

Publications

• Bhattacharya, Madhushree; Sadeghi, Amir; Sarkhel, Sanjay; Hagström, Marja; Bahrpeyma, Sina; Toropainen, Elisa; Auriola, Seppo; Urtti, Arto. 2020. Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery Journal of controlled release 327: 584-594. 2020
• Kilpeläinen, Tommi P; Hellinen, Laura; Vrijdag, Johannes; Yan, Xu; Svarcbahs, Reinis; Vellonen, Kati-Sisko; Lambeir, Anne-Marie; Huttunen, Henri; Urtti, Arto; Wallen, Erik; Myöhänen, Timo. 2020. The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy Biomedicine and pharmacotherapy 128: 110253. 2020
• Tavakoli, Shirin; Kari, Otto Kalevi; Turunen, Tiina; Lajunen, Tatu; Schmitt, Mechthild; Lehtinen, Julia; Tasaka, Fumitaka; Parkkila, Petteri; Ndika, Joseph; Viitala, Tapani; Alenius, Harri; Urtti, Arto; Subrizi, Astrid. 2020. Diffusion and Protein Corona Formation of Lipid-Based Nanoparticles in the Vitreous Humor: Profiling and Pharmacokinetic Considerations Molecular pharmaceutics [Epub ahead of print 8 July 2020]: -. 2020
• Sridevi Gurubaran, Iswariyaraja; Viiri, Johanna; Koskela, Ali; Hyttinen, Juha M; Paterno, Jussi; Kis, Gréta; Antal, Miklós; Urtti, Arto; Kauppinen, Anu; Felszeghy, Szabolcs; Kaarniranta, Kai. 2020. Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model International journal of molecular sciences 21 6: 1976. 2020
• Shakirova, Julia R; Sadeghi, Amir; Koblova, Alla A; Chelushkin, Pavel S; Toropainen, Elisa; Tavakoli, Shirin; Kontturi, Leena-Stiina; Lajunen, Tatu; Tunik, Sergey P; Urtti, Arto. 2020. Design and synthesis of lipid-mimetic cationic iridium complexes and their liposomal formulation for in vitro and in vivo application in luminescent bioimaging Rsc advances 10 24: 14431-14440. 2020
• Ramsay, Eva; Raviña, Manuela; Sarkhel, Sanjay; Hehir, Sarah; Cameron, Neil R; Ilmarinen, Tanja; Skottman, Heli; Kjems, Jørgen; Urtti, Arto; Ruponen, Marika; Subrizi, Astrid. 2020. Avoiding the Pitfalls of siRNA Delivery to the Retinal Pigment Epithelium with Physiologically Relevant Cell Models. Pharmaceutics 12 7: 667. 2020
• Osipova, O; Sharoyko, V; Zashikhina, N; Zakharova, N; Tennikova, T; Urtti, A; Korzhikova-Vlakh, E. 2020. Amphiphilic Polypeptides for VEGF siRNA Delivery into Retinal Epithelial Cells Pharmaceutics 12 1: 39. 2020
• Heikkinen, Emma M; Ruponen, Marika; Jasper, Lisa-Marie; Leppänen, Jukka; Hellinen, Laura; Urtti, Arto; Auriola, Seppo; Rautio, Jarkko; Vellonen, Kati-Sisko. 2020. Prodrug Approach for Posterior Eye Drug Delivery: Synthesis of Novel Ganciclovir Prodrugs and in Vitro Screening with Cassette Dosing Molecular pharmaceutics 17 6: 1945-1953. 2020
• Kari, Otto K; Tavakoli, Shirin; Parkkila, Petteri; Baan, Simone; Savolainen, Roosa; Ruoslahti, Teemu; Johansson, Niklas G; Ndika, Joseph; Alenius, Harri; Viitala, Tapani; Urtti, Arto; Lajunen, Tatu. 2020. Light-Activated Liposomes Coated with Hyaluronic Acid as a Potential Drug Delivery System Pharmaceutics 12 8: 763. 2020
• Ilochonwu, Blessing C; Urtti, Arto; Hennink, Wim E; Vermonden, Tina. 2020. Intravitreal hydrogels for sustained release of therapeutic proteins Journal of controlled release 326: 419-441. 2020
• Hemmilä, Samu; Ruponen, Marika; Toropainen, Elisa; Tengvall-Unadike, Unni; Urtti, Arto; Kallio, Pasi. 2020. Microflow-Based Device for In Vitro and Ex Vivo Drug Permeability Studies SLAS technology [Epub ahead of print 30 April 2020]: 1-8. 2020
• Helvig, Shen Y; Andersen, Helene; Antopolsky, Maxim; Airaksinen, Anu J; Urtti, Arto; Yaghmur, Anan; Moghimi, Seyed M. 2020. Hexosome engineering for targeting of regional lymph nodes Materialia 11: 100705. 2020
• Hellinen, Laura; Bahrpeyma, Sina; Rimpelä, Anna-Kaisa; Hagström, Marja; Reinisalo, Mika; Urtti, Arto. 2020. Microscale Thermophoresis as a Screening Tool to Predict Melanin Binding of Drugs Pharmaceutics 12 6: 554. 2020
• Itkonen, Jaakko; Annala, Ada; Tavakoli, Shirin; Arango-Gonzalez, Blanca; Ueffing, Marius; Toropainen, Elisa; Ruponen, Marika; Casteleijn, Marco G; Urtti, Arto. 2020. Characterization, Stability, and in Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation Into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models Pharmaceutics 12 7: E611. 2020
• Serri, Carla; Frigione, Mariaenrica; Ruponen, Marika; Urtti, Arto; Borzacchiello, Assunta; Biondi, Marco; Mayol, Laura. 2019. Electron dispersive X-ray spectroscopy and degradation properties of hyaluronic acid decorated microparticles Colloids and surfaces b: biointerfaces 181: 896-901. 2019
• Kontturi, LS; van den Dikkenberg, J; Urtti, A; Hennink, WE; Mastrobattista, E. 2019. Light-Triggered Cellular Delivery of Oligonucleotides Pharmaceutics 11 2: 90. 2019
• Ramsay, E; Hagström, M; Vellonen, KS; Boman, S; Toropainen, E; Del Amo, EM; Kidron, H; Urtti, A; Ruponen, M. 2019. Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation European journal of pharmaceutics and biopharmaceutics 143: 18-23. 2019
• Rimpelä, AK; Kiiski, I; Deng, F; Kidron, H; Urtti, A. 2019. Pharmacokinetic Simulations of Intravitreal Biologicals: Aspects of Drug Delivery to the Posterior and Anterior Segments Pharmaceutics 11 1: 9. 2019
• Schmitt, Mechthild; Hippeläinen, Eero; Raviña, Manuela; Arango-Gonzalez, Blanca; Antopolsky, Maxim; Vellonen, Kati-Sisko; Airaksinen, Anu J; Urtti, Arto. 2019. Intravitreal Pharmacokinetics in Mice: SPECT/CT Imaging and Scaling to Rabbits and Humans Molecular pharmaceutics 16 10: 4399-4404. 2019
• Tennikova, Tatiana; Urtti, Arto. 2019. Modified cells as potential ocular drug delivery systems Drug discovery today 24 8: 1621-1626. 2019
• Smedowski, A; Akhtar, S; Liu, X; Pietrucha-Dutczak, M; Podracka, L; Toropainen, E; Alkanaan, A; Ruponen, M; Urtti, A; Varjosalo, M; Kaarniranta, K; Lewin-Kowalik, J. 2019. Electrical synapses interconnecting axons revealed in the optic nerve head - a novel model of gap junctions' involvement in optic nerve function Acta ophthalmologica [Epub ahead of print 10 Oct 2019]: 1-10. 2019
• Subrizi, A; Amo, EMD; Korzhakov-Vlakh, V; Tennikova, T; Ruponen, M; Urtti, A. 2019. Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties Drug discovery today 24 8: 1446-1457. 2019
• Kari, OK; Ndika, J; Parkkila, P; Louna, A; Lajunen, T; Puustinen, A; Viitala, T; Alenius, H; Urtti, A. 2019. In situ analysis of liposome hard and soft protein corona structure and composition in a single label-free workflow Nanoscale 2020; 12 3: 1728-1741. 2019
• Urtti, Arto. 2019. Comment on "Topical Delivery of Avastin to the Posterior Segment of the Eye In Vivo Using Annexin A5-Associated Liposomes": Topical Liposomal Bevacizumab Results in Negligible Retinal Concentrations Small 15 15: 1805199. 2019
• Urtti, Arto. 2019. Retinal bioavailability of liposomal minocycline after sub-conjunctival administration is low Nanomedicine: nanotechnology biology and medicine 18: 427. 2019
• Kompella, UB; Domb, A; Urtti, A; Jayagopal, A; Wilson, CG; Tang-Liu, D. 2019. ISOPT Clinical Hot Topic Panel Discussion on Ocular Drug Delivery Journal of ocular pharmacology and therapeutics 35 8: 457-465. 2019
• Teirlinck, E; Barras, A; Liu, J; Fraire, JC; Lajunen, T; Xiong, R; Forier, K; Li, C; Urtti, A; Boukherroub, R; Szunerits, S; De Smedt, SC; Coenye, T; Braeckmans, K. 2019. Exploring Light-Sensitive Nanocarriers for Simultaneous Triggered Antibiotic Release and Disruption of Biofilms Upon Generation of Laser-Induced Vapor Nanobubbles Pharmaceutics 11 5: 201. 2019
• Kalinin, Stanislav; Valtari, Annika; Ruponen, Marika; Toropainen, Elisa; Kovalenko, Alexander; Nocentini, Alessio; Gureev, Maxim; Dar'in, Dmitry; Urtti, Arto; Supuran, Claudiu T; Krasavin, Mikhail. 2019. Highly Hydrophilic 1,3-Oxazol-5-yl Benzenesulfonamide Inhi bitors of Carbonic Anhydrase II for Reduction of Glaucoma-Related Intraocular Pressure Bioorganic and medicinal chemistry 27 11: 115086. 2019
• Galli, E; Lindholm, P; Kontturi, LS; Saarma, M; Urtti, A; Yliperttula, M. 2019. Characterization of CDNF-Secreting ARPE-19 Cell Clones for Encapsulated Cell Therapy Cell transplantation 28 4: 412-424. 2019
• Jakubiak, Paulina; Lack, Flavio; Thun, Jurgen; Urtti, Arto; Alvarez-Sanchez, Ruben. 2019. Influence of Melanin Characteristics on Drug Binding Properties Molecular pharmaceutics 16 6: 2549-2556. 2019
• Churilov, Leonid; Korzhikov-Vlakh, Viktor; Sinitsyna, Ekaterina; Polyakov, Dmitry; Darashkevich, Oleg; Poida, Mikhail; Platonova, Galina; Vinogradiva, Tatiana; Utekhin, Vladimir; Zabolotnykh, Natalia; Zinserling, Vsevolod; Yablonsky, Peter; Urtti, Arto; Tennikova, Tatiana. 2019. Enhanced Delivery of 4-Thioureidoiminomethylpyridinium Perchlorate in Tuberculosis Models with IgG Functionalized Poly(Lactic Acid)-Based Particles Pharmaceutics 11 1: 2. 2019
• Fayyaz, A; Ranta, VP; Toropainen, E; Vellonen, KS; Ricci, GD; Reinisalo, M; Heikkinen, EM; Gardner, I; Urtti, A; Jamei, M; del Amo, EM. 2019. Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits Molecular pharmaceutics 12 4: e007045. 2019
• Chandola, C; Casteleijn, MG; Chandola, UM; Gopalan, LN; Urtti, A; Neerathilingam, M. 2019. CD44 aptamer mediated cargo delivery to lysosomes of retinal pigment epithelial cells to prevent age-related macular degeneration Biochemistry and Biophysics Reports 18: 100642. 2019
• Fusciello, M; Fontana, F; Tähtinen, S; Capasso, C; Feola, S; Martins, B; Chiaro, J; Peltonen, K; Ylösmäki, L; Ylösmäki, E; Hamdan, F; Kari, OK; Ndika, J; Alenius, H; Urtti, A; Hirvonen, JT; Santos, HA; Cerullo, V. 2019. Artificially cloaked viral nanovaccine for cancer immunotherapy Nature communications 10: 5747. 2019
• Dubashynskaya, N; Poshina, D; Raik, S; Urtti, A; Skorik, YA. 2019. Polysaccharides in Ocular Drug Delivery Pharmaceutics 12 1: 22. 2019
• Harloff-Helleberg, S; Fliervoet, LAL; Fanø, M; Schmitt, M; Antopolski, M; Urtti, A; Nielsen, HM. 2019. Exploring the mucoadhesive behavior of sucrose acetate isobutyrate: a novel excipient for oral delivery of biopharmaceuticals Drug delivery 26 1: 532-541. 2019
• Heikkinen, EM; Auriola, S; Ranta, VP; Demarais, N; Grey, A; Del Amo, E; Toropainen, E; Vellonen, KS; Urtti, A; Ruponen, M. 2019. Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics Molecular pharmaceutics 16 9: 3968-3976. 2019
• Hellinen, L; Hagström, M; Knuutila, H; Ruponen, M; Urtti, A; Reinisalo, M. 2019. Characterization of artificially re-pigmented ARPE-19 retinal pigment epithelial cell model Scientific reports 9 1: 13761. 2019
• Hellinen, L; Pirskanen, L; Tengvall-Unadike, U; Urtti, A; Reinisalo, M. 2019. Retinal Pigment Epithelial Cell Line with Fast Differentiation and Improved Barrier Properties Pharmaceutics 11 8: 412. 2019
• Hellinen, Laura; Sato, Kazuki; Reinisalo, Mika; Kidron, Heidi; Rilla, Kirsi; Tachikawa, Masanori; Uchida, Yasuo; Terasaki, Tetsuya; Urtti, Arto. 2019. Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters Investigative ophthalmology and visual science 60 15: 5022-5034. 2019
• Jakubiak, Paulina; Cantrill, Carina; Urtti, Arto; Alvarez-Sanchez, Ruben. 2019. Establishment of an In Vitro-In Vivo Correlation for Melanin Binding and the Extension of the Ocular Half-Life of Small-Molecule Drugs Molecular pharmaceutics 16 12: 4890-4901. 2019
• Vellonen, Kati-Sisko; Hellinen, Laura; Mannermaa, Eliisa; Ruponen, Marika; Urtti, Arto; Kidron, Heidi. 2018. Expression, activity and pharmacokinetic impact of ocular transporters ADVANCED DRUG DELIVERY REVIEWS 126: 3-22. 2018
• Suun kautta otettujen lääkeaineiden imeytyminen. Urtti, Arto; Ruponen, Marika; Pajula, Katja; Yliperttula, Marjo; Honkakoski, Paavo; Ranta, Veli-Pekka; Kidron, Heidi; Vellonen, Kati-Sisko / Biofarmasian perusteet. 2018. 2018
• Rimpelä, Anna-Kaisa; Hagström, Marja; Kidron, Heidi; Urtti, Arto. 2018. Melanin targeting for intracellular drug delivery: Quantification of bound and free drug in retinal pigment epithelial cells JOURNAL OF CONTROLLED RELEASE 283: 261-268. 2018
• Ramsay, Eva; del Amo, Eva M; Toropainen, Elisa; Tengvall-Unadike, Unni; Ranta, Veli-Pekka; Urtti, Arto; Ruponen, Marika. 2018. Corneal and conjunctival drug permeability : systematic comparison and pharmacokinetic impact in the eye European journal of pharmaceutical sciences 119: 83-89. 2018
• Lääkkeenanto laskimoon, lihakseen ja ihan alle. Urtti, Arto; Ruponen, Marika / Biofarmasian perusteet. 2018. 2018
• Lamminsalo, Marko; Taskinen, Ella; Karvinen, Timo; Subrizi, Astrid; Murtomäki, Lasse; Urtti, Arto: Ranta, Veli-Pekka. 2018. Extended Pharmacokinetic Model of the Rabbit Eye for Intravitreal and Intracameral Injections of Macromolecules: Quantitative Analysis of Anterior and Posterior Elimination Pathways Pharmaceutical research 35 8: 153. 2018
• Jakubiak, Paulina; Reutlinger, Michael; Mattei, Patrizio; Schuler, Franz; Urtti, Arto; Alvarez-Sanchez, Ruben. 2018. Understanding Molecular Drivers of Melanin Binding To Support Rational Design of Small Molecule Ophthalmic Drugs JOURNAL OF MEDICINAL CHEMISTRY 61 22: 10106-10115. 2018
• Iho lääkeaineiden antoreittinä. Urtti, Arto; Ruponen, Marika; Pajula, Katja; Vellonen, Kati-Sisko / Biofarmasian perusteet. 2018. 2018
• Biofarmasian tulevaisuuden näkymiä. Honkakoski; Paavo; Urtti; Arto / Biofarmasian perusteet. 2018. 2018
• Biofarmasian perustekijät. Urtti, Arto; Yliperttula, Marjo; Ruponen, Marika / Biofarmasian perusteet. 2018. 2018
• Pelkonen L, Sato K, Reinisalo M, Kidron H, Tachikawa M, Watanabe M, Uchida Y, Urtti A, Terasaki T. 2017. LC-MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line. Molecular Pharmaceutics 14 3: 605-613. 2017
• del Amo Eva M, Rimpelä Anna-Kaisa, Heikkinen Emma, Kari Otto K, Ramsay Eva, Lajunen Tatu, Schmitt Mechthild, Pelkonen Laura, Bhattacharya Madhushree, Richardson Dominique, Subrizi Astrid, Turunen Tiina, Reinisalo Mika, Itkonen Jaakko, Toropainen Elisa, Casteleijn Marco, Kidron Heidi, Antopolsky Maxim, Vellonen Kati-Sisko, Ruponen Marika, et al.. 2017. Pharmacokinetic aspects of retinal drug delivery PROGRESS IN RETINAL AND EYE RESEARCH 57: 134-185. 2017
• Bhattacharya M, Sarkhel S, Peltoniemi J, Broadbridge R, Tuomainen M, Auriola S, Urtti A. 2017. Differentially cleaving peptides as a strategy for controlled drug release in human retinal pigment epithelial cells. JOURNAL OF CONTROLLED RELEASE 251: 37-48. 2017
• Soininen Suvi K, Vellonen Kati-Sisko, Heikkinen Aki T, Auriola Seppo, Ranta Veli-Pekka, Urtti Arto, Ruponen Marika. 2016. Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling. Molecular Pharmaceutics 13 4: 1358-1365. 2016
• Rimpelä Anna-Kaisa, Schmitt Mechthild, Latonen Satu, Hagström Marja, Antopolsky Maxim, Manzanares José A, Kidron Heidi, Urtti Arto. 2016. Drug Distribution to Retinal Pigment Epithelium: Studies on Melanin Binding, Cellular Kinetics, and Single Photon Emission Computed Tomography/Computed Tomography Imaging. Molecular Pharmaceutics 13 9: 2977-2986. 2016
• Lajunen Tatu, Kontturi Leena-Stiina, Viitala Lauri, Manna Moutusi, Cramariuc Oana, Róg Tomasz, Bunker Alex, Laaksonen Timo, Viitala Tapani, Murtomäki Lasse, Urtti Arto. 2016. Indocyanine Green-Loaded Liposomes for Light-Triggered Drug Release. Molecular Pharmaceutics 13 6: 2095-2107. 2016
• Vellonen Kati-Sisko, Soini Esa-Matti, del Amo Eva M, Urtti Arto. 2015. Prediction of ocular drug distribution from systemic blood circulation. Molecular Pharmaceutics 13 (2016) 9: 2906-2911. 2015
• Lajunen Tatu, Viitala Lauri, Kontturi Leena-Stiina, Laaksonen Timo, Liang Huamin, Vuorimaa-Laukkanen Elina, Viitala Tapani, Le Guével Xavier, Yliperttula Marjo, Murtomäki Lasse, Urtti Arto. 2015. Light induced cytosolic drug delivery from liposomes with gold nanoparticles. JOURNAL OF CONTROLLED RELEASE 203: 85-98. 2015
• Del Amo Eva M, Vellonen Kati-Sisko, Kidron Heidi, Urtti Arto. 2015. Intravitreal clearance and volume of distribution of compounds in rabbits: In silico prediction and pharmacokinetic simulations for drug development. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 95: 215-226. 2015
• Del Amo Eva M, Urtti Arto. 2015. Rabbit as an animal model for intravitreal pharmacokinetics: Clinical predictability and quality of the published data Experimental eye research 137: 111-124. 2015
• Vellonen Kati-Sisko, Malinen Melina, Mannermaa Eliisa, Subrizi Astrid, Toropainen Elisa, Lou Yan-Ru, Kidron Heidi, Yliperttula Marjo, Urtti Arto. 2014. A critical assessment of in vitro tissue models for ADME and drug delivery. JOURNAL OF CONTROLLED RELEASE 190: 94-114. 2014
• Nilsson Christa, Østergaard Jesper, Weng Larsen Susan, Larsen Claus, Urtti Arto, Yaghmur Anan. 2014. PEGylation of phytantriol-based lyotropic liquid crystalline particles - the effect of lipid composition, PEG chain length, and temperature on the internal nanostructure. LANGMUIR 30: 6398-6407. 2014
• Malinen Melina M, Kanninen Liisa K, Corlu Anne, Isoniemi Helena M, Lou Yan-Ru, Yliperttula Marjo L, Urtti Arto O. 2014. Differentiation of liver progenitor cell line to functional organotypic cultures in 3D nanofibrillar cellulose and hyaluronan-gelatin hydrogels. BIOMATERIALS 35: 5110-5121. 2014
• Kontturi Leena-Stiina, Collin Estelle C, Murtomäki Lasse, Pandit Abhay S, Yliperttula Marjo, Urtti Arto. 2014. Encapsulated cells for long-term secretion of soluble VEGF receptor 1: material optimization and simulation of ocular drug response. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 2015; 95 Part B: 387-397. 2014
• Linnankoski J, Mäkelä JM, Ranta V-P, Urtti A, Yliperttula M. 2006. Computational prediction of oral drug absorption based on absorption rate constants in humans. JOURNAL OF MEDICINAL CHEMISTRY 49: 3674-3681. 2006
• Pitkänen L, Ranta V-P, Moilanen H, Urtti A. 2005. Permeability of retinal pigment epithelium: Effects of permeant molecular weight and lipophilicity. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 46 2: 641-646. 2005

Research groups

• Ocular Drug Delivery group (ODD)