Asla Pitkänen

Brain abscess – A rare confounding factor for diagnosis of post-traumatic epilepsy after lateral fluid-percussion injury

Kyyriäinen, Jenni; Andrade, Pedro; Ekolle Ndode-Ekane, Xavier; Manninen, Eppu; Hämäläinen, Elina; Rauramaa, Tuomas; Heiskanen, Mette; Puhakka, Noora; Immonen, Riikka; Pitkänen, Asla. 2024. Epilepsy research. 200: A1 Journal article (refereed), original research

Circulating microRNAs and isomiRs as biomarkers for the initial insult and epileptogenesis in four experimental epilepsy models: The EPITARGET study

van Vliet, Erwin A; Scheper, Mirte; Mills, James D; Puhakka, Noora; Szydlowska, Kinga; Ferracin, Manuela; Lovisari, Francesca; Soukupova, Marie; Zucchini, Silvia; Srivastava, Prashant K; Johnson, Michael R; Lukasiuk, Katarzyna; Gorter, Jan A; Aronica, Eleonora; Pitkänen, Asla; Simonato, Michele. 2024. Epilepsia. 65: 3406-3420 A1 Journal article (refereed), original research

Plasma microRNAs as prognostic biomarkers for development of severe epilepsy after experimental traumatic brain injury —EpiBioS4Rx Project 1 study

Heiskanen, Mette; Ndode‐Ekane, Xavier Ekolle; Ali, Idrish; Santana‐Gomez, Cesar; Puhakka, Noora; Gupta, Shalini Das; Andrade, Pedro; Immonen, Riikka; Casillas‐Espinosa, Pablo; Manninen, Eppu; Smith, Gregory; Brady, Rhys D.; Silva, Juliana; Braine, Emma; Hudson, Matt; Yamakawa, Glen R.; Jones, Nigel C.; Shultz, Sandy R.; Harris, Neil G.; Wright, David K.; Gröhn, Olli; Staba, Richard J.; O'Brien, Terence J.; Pitkänen, Asla. 2024. Epilepsia. [First published: 11 December 2024]: 1-16 A1 Journal article (refereed), original research

Plasma neurofilament heavy chain is a prognostic biomarker for the development of severe epilepsy after experimental traumatic brain injury

Heiskanen, Mette; Banuelos, Ivette; Manninen, Eppu; Andrade, Pedro; Hämäläinen, Elina; Puhakka, Noora; Pitkänen, Asla. 2024. Epilepsia. 65: 3703-3716 A1 Journal article (refereed), original research

Discovery and Validation of Circulating microRNAs as Biomarkers for Epileptogenesis after Experimental Traumatic Brain Injury–The EPITARGET Cohort

Heiskanen, Mette; Das Gupta, Shalini; Mills, James D; van Vliet, Erwin A; Manninen, Eppu; Ciszek, Robert; Andrade, Pedro; Puhakka, Noora; Aronica, Eleonora; Pitkänen, Asla. 2023. International journal of molecular sciences. 24: A1 Journal article (refereed), original research

Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1

Ndode‐Ekane, Xavier Ekolle; Ali, Idrish; Santana‐Gomez, Cesar; Andrade, Pedro; Immonen, Riikka; Casillas‐Espinosa, Pablo; Paananen, Tomi; Manninen, Eppu; Puhakka, Noora; Smith, Gregory; Brady, Rhys D; Silva, Juliana; Braine, Emma; Hudson, Matt; Yamakawa, Glen R; Jones, Nigel C; Shultz, Sandy R; Harris, Neil; Wright, David K; Gröhn, Olli; Staba, Richard; O'Brien, Terence J; Pitkänen, Asla. 2023. Epilepsia. 2024; 65: 511-526 A1 Journal article (refereed), original research

Gene Expression Profile as a Predictor of Seizure Liability

Lipponen, Anssi; Kajevu, Natallie; Natunen, Teemu; Ciszek, Robert; Puhakka, Noora; Hiltunen, Mikko; Pitkänen, Asla. 2023. International journal of molecular sciences. 24: A1 Journal article (refereed), original research

Highlights From the Annual Meeting of the American Epilepsy Society 2022

Valencia, Ignacio; Alexander, Allyson L.; Andrade, Danielle M.; Arevalo-Astrada, Miguel; Rubiños, Clio; Auer, Nancy; Bainbridge, Jacquelyn L.; Baxendale, Sallie A.; Bartolomei, Fabrice; Becker, Danielle A.; Berg, Anne T.; Bernasconi, Andrea; Bernasconi, Neda; Bernhardt, Boris; Bhatnagar, Shivani; Blümcke, Ingmar; Blumenfeld, Hal; Buchanan, Gordon F.; Burdette, David E.; Burneo, Jorge G.; Busch, Robyn M.; Chauvel, Patrick; Chin, Jeannie; Clifford, Lisa; Conner, Kelly R.; Cook, Mark J.; Conway, Je. 2023. Epilepsy currents. [Epub ahead of print 16 Aug 2023]: 1-36 B1 Non-refereed journal articles

Image data harmonization tools for the analysis of post-traumatic epilepsy development in preclinical multisite MRI studies

Bhagavatula, Sweta; Cabeen, Ryan; Harris, Neil G.; Gröhn, Olli; Wright, David K.; Garner, Rachael; Bennett, Alexis; Alba, Celina; Martinez, Aubrey; Ndode-Ekane, Xavier Ekolle; Andrade, Pedro; Paananen, Tomi; Ciszek, Robert; Immonen, Riikka; Manninen, Eppu; Puhakka, Noora; Tohka, Jussi; Heiskanen, Mette; Ali, Idrish; Shultz, Sandy R.; Casillas-Espinosa, Pablo M.; Yamakawa, Glenn R.; Jones, Nigel C.; Hudson, Matthew R.; Silva, Juliana C.; Braine, Emma L.; Brady, Rhys D.; Santana-Gomez, Cesar E.; S. 2023. Epilepsy research. 195: A1 Journal article (refereed), original research

Proteomics of Deep Cervical Lymph Nodes After Experimental Traumatic Brain Injury

Puhakka, Noora; Das Gupta, Shalini; Leskinen, Sara; Heiskanen, Mette; Nattinen, Janika; Aapola, Ulla; Uusitalo, Hannu; Pitkanen, Asla. 2023. Neurotrauma reports. 4: 359-366 A1 Journal article (refereed), original research

Sleep Disturbance and Severe Hydrocephalus in a Normally Behaving Wistar Rat With Traumatic Brain Injury

Kyyriäinen, Jenni; Andrade, Pedro; Hämäläinen, Elina; Pitkänen, Asla. 2023. Neurotrauma reports. 4: 384-395 A1 Journal article (refereed), original research

Successful harmonization in EpiBioS4Rx biomarker study on post-traumatic epilepsy paves the way towards powered preclinical multicenter studies

Ndode-Ekane, Xavier Ekolle; Ali, Idrish; Santana-Gomez, Cesar E; Casillas-Espinosa, Pablo M; Andrade, Pedro; Smith, Gregory; Paananen, Tomi; Manninen, Eppu; Immonen, Riikka; Puhakka, Noora; Ciszek, Robert; Hämäläinen, Elina; Brady, Rhys D; Silva, Juliana; Braine, Emma; Hudson, Matthew R; Yamakawa, Glenn; Jones, Nigel C; Shultz, Sandy R; Wright, David; Harris, Neil; Gröhn, Olli; Staba, Richard J; O’Brien, Terence J; Pitkänen, Asla. 2023. Epilepsy research. 2024; 199: A1 Journal article (refereed), original research

Treatment of Status Epilepticus after Traumatic Brain Injury Using an Antiseizure Drug Combined with a Tissue Recovery Enhancer Revealed by Systems Biology

Kajevu, Natallie; Lipponen, Anssi; Andrade, Pedro; Bañuelos, Ivette; Puhakka, Noora; Hämäläinen, Elina; Natunen, Teemu; Hiltunen, Mikko; Pitkänen, Asla. 2023. International journal of molecular sciences. 24: . 14049 A1 Journal article (refereed), original research

Acute Hippocampal Damage as a Prognostic Biomarker for Cognitive Decline but Not for Epileptogenesis after Experimental Traumatic Brain Injury

Manninen, Eppu; Chary, Karthik; De Feo, Riccardo; Hämäläinen, Elina; Andrade, Pedro; Paananen, Tomi; Sierra, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkänen, Asla. 2022. Biomedicines. 10: A1 Journal article (refereed), original research

Chronic hypometabolism in striatum and hippocampal network after traumatic brain injury and their relation with memory impairment – [18F]-FDG-PET and MRI 4 months after fluid percussion injury in rat

Yasmin, Amna; Jokivarsi, Kimmo; Poutiainen, Pekka; Pitkänen, Asla; Gröhn, Olli; Immonen, Riikka. 2022. Brain research. 1788: A1 Journal article (refereed), original research

Convolutional Neural Networks Enable Robust Automatic Segmentation of the Rat Hippocampus in MRI After Traumatic Brain Injury

De Feo, Riccardo; Hämäläinen, Elina; Manninen, Eppu; Immonen, Riikka; Valverde, Juan Miguel; Ndode-Ekane, Xavier Ekolle; Gröhn, Olli; Pitkänen, Asla; Tohka, Jussi. 2022. Frontiers in neurology. 13: . 820267 A1 Journal article (refereed), original research

Effect of cell culture media on extracellular vesicle secretion from mesenchymal stromal cells and neurons

Karttunen, Jenni; Heiskanen, Mette; Joki, Tiina; Hyysalo, Anu; Navarro-Ferrandis, Vicente; Miettinen, Susanna; Narkilahti, Susanna; Pitkänen, Asla. 2022. European journal of cell biology. 101: A1 Journal article (refereed), original research

Hippocampal position and orientation as prognostic biomarkers for posttraumatic epileptogenesis: An experimental study in a rat lateral fluid percussion model

De Feo, Riccardo; Manninen, Eppu; Chary, Karthik; Hämäläinen, Elina; Immonen, Riikka; Andrade, Pedro; Ndode‐Ekane, Xavier Ekolle; Gröhn, Olli; Pitkänen, Asla; Tohka, Jussi. 2022. Epilepsia. 63: 1849-1861 A1 Journal article (refereed), original research

International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke

Mishra, Nishant K.; Engel, Jerome; Liebeskind, David S.; Sharma, Vijay K.; Hirsch, Lawrence J.; Kasner, Scott E; French, Jacqueline A.; Devinsky, Orrin; Friedman, Alon; Dawson, Jesse; Quinn, Terence J.; Selim, Magdy; de Havenon, Adam; Yasuda, Clarissa L.; Cendes, Fernando; Benninger, Felix; Zaveri, Hitten P.; Burneo, Jorge G.; Srivastava, Padma; Bhushan Singh, Mamta; Bhatia, Rohit; Vishnu, V.Y.; Bentes, Carla; Ferro, Jose; Weiss, Shennan; Sivaraju, Adithya; Kim, Jennifer A.; Galovic, Marian; Gil. 2022. Epilepsy and behavior. 127: B1 Non-refereed journal articles

MRI-Guided Electrode Implantation for Chronic Intracerebral Recordings in a Rat Model of Post−Traumatic Epilepsy—Challenges and Gains

Ndode-Ekane, Xavier Ekolle; Immonen, Riikka; Hämäläinen, Elina; Manninen, Eppu; Andrade, Pedro; Ciszek, Robert; Paananen, Tomi; Gröhn, Olli; Pitkänen, Asla. 2022. Biomedicines. 10: A1 Journal article (refereed), original research

Plasma Neurofilament Light Chain (NF-L) Is a Prognostic Biomarker for Cortical Damage Evolution but Not for Cognitive Impairment or Epileptogenesis Following Experimental TBI

Heiskanen, Mette; Jääskeläinen, Olli; Manninen, Eppu; Das Gupta, Shalini; Andrade, Pedro; Ciszek, Robert; Gröhn, Olli; Herukka, Sanna-Kaisa; Puhakka, Noora; Pitkänen, Asla. 2022. International journal of molecular sciences. 23: A1 Journal article (refereed), original research

Seizure Susceptibility and Sleep Disturbance as Biomarkers of Epileptogenesis after Experimental TBI

Andrade, Pedro; Lara-Valderrábano, Leonardo; Manninen, Eppu; Ciszek, Robert; Tapiala, Jesse; Ndode-Ekane, Xavier Ekolle; Pitkänen, Asla. 2022. Biomedicines. 10: A1 Journal article (refereed), original research

Shaping the future of European epilepsy research: Final meeting report from EPICLUSTER

Henshall, David C.; Arzimanoglou, Alexis; Dedeurwaerdere, Stefanie; Guerrini, Renzo; Jozwiak, Sergiusz; Kokaia, Merab; Lerche, Holger; Pitkänen, Asla; Ryvlin, Philippe; Simonato, Michele; Sisodiya, Sanjay M.. 2022. Epilepsy research. 2023; 189: B1 Non-refereed journal articles

Transfer RNA-Derived Fragments and isomiRs Are Novel Components of Chronic TBI-Induced Neuropathology

Puhakka, Noora; Das Gupta, Shalini; Vuokila, Niina; Pitkänen, Asla. 2022. Biomedicines. 10: A1 Journal article (refereed), original research

Ultrasonic vocalizations – Novel seizure-related manifestation in rats

Lara-Valderrábano, Leonardo; Ciszek, Robert; Bañuelos-Cabrera, Ivette; Andrade, Pedro; Pitkänen, Asla. 2022. Epilepsy research. 183: A1 Journal article (refereed), original research

Acute thalamic damage as a prognostic biomarker for post-traumatic epileptogenesis

Manninen, Eppu; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkänen, Asla. 2021. Epilepsia. 62: 1852-1864 A1 Journal article (refereed), original research

Biomarkers for posttraumatic epilepsy

Pitkänen, Asla; Paananen, Tomi; Kyyriäinen, Jenni; Das Gupta, Shalini; Heiskanen, Mette; Vuokila, Niina; Bañuelos-Cabrera, Ivette; Lapinlampi, Niina; Kajevu, Natallie; Andrade, Pedro; Ciszek, Robert; Lara-Valderrábano, Leonardo; Ekolle Ndode-Ekane, Xavier; Puhakka, Noora. 2021. Epilepsy and behavior. 121: 107080 A2 Review article, Literature review, Systematic review

Climate change and epilepsy: Insights from clinical and basic science studies

Gulcebi, Medine I; Bartolini, Emanuele; Lee, Omay; Lisgaras, Christos Panagiotis; Onat, Filiz; Mifsud, Janet; Striano, Pasquale; Vezzani, Annamaria; Hildebrand, Michael S; Jimenez-Jimenez, Diego; Junck, Larry; Lewis-Smith, David; Scheffer, Ingrid E; Thijs, Roland D; Zuberi, Sameer M; Blenkinsop, Stephen; Fowler, Hayley J; Foley, Aideen; Sisodiya, Sanjay M; Balestrini, Simona et al. [incl. Pitkänen, Asla]. 2021. Epilepsy and behavior. 116: 107791 A2 Review article, Literature review, Systematic review

Identification of clinically relevant biomarkers of epileptogenesis - a strategic roadmap

Simonato, Michele; Agoston, Denes V; Brooks-Kayal, Amy; Dulla, Chris; Fureman, Brandy; Henshall, David C; Pitkänen, Asla; Theodore, William H; Twyman, Roy E; Kobeissy, Firas H; Wang, Kevin K; Whittemore, Vicky; Wilcox, Karen S. 2021. Nature reviews neurology. 17: 231-242 A2 Review article, Literature review, Systematic review

Meeting report: EpiXchange II brings together European epilepsy research projects to discuss latest advances

Henshall, David C.; Guerrini, Renzo; Jozwiak, Sergiusz; Kokaia, Merab; Pitkanen, Asla; Sisodiya, Sanjay; Simonato, Michele; Cross, J. Helen; Ryvlin, Philippe; Brodie, Martin J.; Trinka, Eugen; Sofia, Francesca. 2021. Epilepsy research. 178: 106811 B1 Non-refereed journal articles

Novel Approaches to Prevent Epileptogenesis After Traumatic Brain Injury

Dulla, Chris G.; Pitkänen, Asla. 2021. Neurotherapeutics. 18: 1582-1601 A2 Review article, Literature review, Systematic review

Peripheral Infection after Traumatic Brain Injury Augments Excitability in the Perilesional Cortex and Dentate Gyrus

Wang, Ying; Andrade, Pedro; Pitkänen Asta. 2021. Biomedicines. 9: 1946 A1 Journal article (refereed), original research

Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury

Das Gupta, Shalini; Ciszek, Robert; Heiskanen, Mette; Lapinlampi, Niina; Kukkonen, Janne; Leinonen, Ville; Puhakka, Noora; Pitkänen, Asla. 2021. International journal of molecular sciences. 22: 1563 A1 Journal article (refereed), original research

Post-injury ventricular enlargement associates with iron in choroid plexus but not with seizure susceptibility nor lesion atrophy - 6-month MRI follow-up after experimental traumatic brain injury

Yasmin, Amna; Pitkänen, Asla; Andrade, Pedro; Paananen, Tomi; Gröhn, Olli; Immonen, Riikka. 2021. Brain structure and function. 2022; 227: 145-158 A1 Journal article (refereed), original research

Regulation of parvalbumin interactome in the perilesional cortex after experimental traumatic brain injury

Hiltunen, Johanna; Ndode-Ekane, Xavier Ekolle; Lipponen, Anssi; Drexel, Meinrad; Sperk, Günther; Puhakka, Noora; Pitkänen, Asla. 2021. Neuroscience. 475: 52-72 A1 Journal article (refereed), original research

Reorganization of Thalamic Inputs to Lesioned Cortex Following Experimental Traumatic Brain Injury

Ndode-Ekane, Xavier Ekolle; Puigferrat Pérez, Maria del Mar; Di Sapia, Rossella; Lapinlampi, Niina; Pitkänen, Asla. 2021. International journal of molecular sciences. 22: 6329 A1 Journal article (refereed), original research

Targeting Oxidative Stress with Antioxidant Duotherapy after Experimental Traumatic Brain Injury

Kyyriäinen, Jenni; Kajevu, Natallie; Bañuelos, Ivette; Lara, Leonardo; Lipponen, Anssi; Balosso, Silvia; Hämäläinen, Elina; Das Gupta, Shalini; Puhakka, Noora; Natunen, Teemu; Ravizza, Teresa; Vezzani, Annamaria; Hiltunen, Mikko; Pitkänen, Asla. 2021. International journal of molecular sciences. 22: 10555 A1 Journal article (refereed), original research

Voiko epilepsian puhkeamisen ja etenemisen estää lääkehoidolla?

Pitkänen, Asla. 2021. Duodecim. 137: 1631 - 1637 A2 Review article, Literature review, Systematic review

A Computational Diffusion MRI Framework for Biomarker Discovery in a Rodent Model of Post-Traumatic Epileptogenesis

Cabeen, Ryan P; Immonen, Riikka; Harris, Neil G; Gröhn, Olli; Smith, Gregory; Manninen, Eppu; Garner, Rachael; Duncan, Dominique; Pitkänen, Asla; Toga, Arthur W. Teoksessa: -(toim.) , 2020. 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI). s. 1013-1017. IEEE A4 Conference proceedings

Biomarkers For Epileptogenesis And Its Treatment

Engel, Jerome Jr; Pitkänen, Asla. 2020. Neuropharmacology. 167: 107735 A2 Review article, Literature review, Systematic review

Chronic Regulation of miR-124-3p in the Perilesional Cortex After Experimental and Human TBI

Vuokila, Niina; Aronica, Eleonora; Korotkov, Anatoly; van Vliet, Erwin Alexander; Nuzhat, Salma; Puhakka, Noora; Pitkänen, Asla. 2020. International journal of molecular sciences. 21: 2418 A1 Journal article (refereed), original research

Droplet digital polymerase chain reaction-based quantification of circulating microRNAs using small RNA concentration normalization

Das Gupta, Shalini; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Pitkänen, Asla. 2020. Scientific reports. 10: 9012 A1 Journal article (refereed), original research

Early increase in cortical T2 relaxation is a prognostic biomarker for the evolution of severe cortical damage, but not for epileptogenesis, after experimental traumatic brain injury

Manninen, Eppu Matias; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra Lopez, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkanen, Asla. 2020. Journal of neurotrauma. 37: 2580-2594 A1 Journal article (refereed), original research

Elevated acute plasma miR-124-3p level relates to evolution of larger cortical lesion area after traumatic brain injury

Vuokila, Niina; Gupta, Shalini Das; Huusko, Riina; Tohka, Jussi; Puhakka, Noora; Pitkänen, Asla. 2020. Neuroscience. 433: 21-35 A1 Journal article (refereed), original research

Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation

Korotkov, Anatoly; Puhakka, Noora; Gupta, Shalini Das; Vuokila, Niina; Broekaart, Diede W M; Anink, Jasper J; Heiskanen, Mette; Karttunen, Jenni; van Scheppingen, Jackelien; Huitinga, Inge; Mills, James D; van Vliet, Erwin A; Pitkänen, Asla; Aronica, Eleonora. 2020. Brain pathology. 30: 897-912 A1 Journal article (refereed), original research

Kainate receptors regulate development of glutamatergic synaptic circuitry in the rodent amygdala

Ryazantseva, Maria; Englund, Jonas; Shintyapina, Alexandra; Huupponen, Johanna; Shteinikov, Vasilii; Pitkänen, Asla; Partanen, Juha; Lauri, Sari. 2020. eLife. 9: e52798 A1 Journal article (refereed), original research

LifeTime and improving European healthcare through cell-based interceptive medicine

Rajewsky, Nikolaus; Almouzni, Geneviève; Gorski, Stanislaw A; Aerts, Stein; Amit, Ido; Bertero, Michela G; Bock, Christoph; Bredenoord, Annelien L; Cavalli, Giacomo; Chiocca, Susanna; Clevers, Hans; Strooper, Bart De; Eggert, Angelika; Ellenberg, Jan; Fernández, Xosé M; Figlerowicz, Marek; Gasser, Susan M; Hubner, Norbert; Kjems, Jørgen; Knoblich, Jürgen A et al. [incl. Pitkänen, Asla; Leinonen, Ville]. 2020. Nature. 587: 377-386 A1 Journal article (refereed), original research

Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury

van Vliet, Erwin A; Ndode-Ekane, Xavier Ekolle; Lehto, Lauri J; Gorter, Jan A; Andrade, Pedro; Aronica, Eleonora; Gröhn, Olli; Pitkänen, Asla. 2020. Neurobiology of disease. 145: 1-20 A1 Journal article (refereed), original research

Plau/Plaur double-deficiency did not worsen lesion severity or vascular integrity after traumatic brain injury

Kyyriäinen, Jenni; Tapiala, Jesse; Lipponen, Anssi; Ekolle Ndode-Ekane, Xavier; Pitkänen, Asla. 2020. Neuroscience letters. 729: 134935 A1 Journal article (refereed), original research

Postinjury weight rather than cognitive or behavioral impairment predicts development of posttraumatic epilepsy after lateral fluid-percussion injury in rats

Lapinlampi, N; Andrade, P; Paananen, T; Hämäläinen, E; Ekolle Ndode-Ekane, X; Puhakka, N; Pitkänen, A. 2020. Epilepsia. 61: 2035-2052 A1 Journal article (refereed), original research

Acute downregulation of novel hypothalamic protein sushi repeat-containing protein X-Linked 2 (SRPX2) after experimental traumatic brain injury

Anwer, Mehwish; Lara-Valderrabano, Leonardo; Karttunen, Jenni; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Pitkänen, Asla. 2019. Journal of neurotrauma. 2020; 37: 924-938 A1 Journal article (refereed), original research

Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats

Andrade, Pedro; Banuelos-Cabrera, Ivette; Lapinlampi, Niina; Paananen, Tomi; Ciszek, Robert; Ndode-Ekane, Xavier Ekolle; Pitkanen, Asla. 2019. Journal of neurotrauma. 36: 1890-1907 A1 Journal article (refereed), original research

Advancing research toward faster diagnosis, better treatment, and end of stigma in epilepsy

Pitkänen, A; Henshall, DC; Cross, JH; Guerrini, R; Jozwiak, S; Kokaia, M; Simonato, M; Sisodiya, S; Mifsud, J. 2019. Epilepsia. 60: 1281-1292 A2 Review article, Literature review, Systematic review

Common data elements (CDEs) for preclinical epilepsy research: Introduction to CDEs and description of core CDEs. A TASK3 report of the ILAE/AES joint translational task force

Harte-Hargrove, Lauren C; Galanopoulou, Aristea S; French, Jacqueline A; Pitkänen, Asla; Whittemore, Vicky; Scharfman, Helen E. 2019. Epilepsia open. 3: 13-23 A1 Journal article (refereed), original research

Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility

Kyyriäinen, J; Bolkvadze, T; Koivisto, H; Lipponen, A; Pérez, LO; Ekolle Ndode-Ekane, X; Tanila, H; Pitkänen, A. 2019. Epilepsy research. 151: 67-74 A1 Journal article (refereed), original research

Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury

Das Gupta, S; Lipponen, A; Paldanius, KMA; Puhakka, N; Pitkänen, A. 2019. Scientific reports. 9: 20208 A1 Journal article (refereed), original research

Epilepsy biomarkers - Toward etiology and pathology specificity

Pitkänen, Asla; Ekolle, Ndode-Ekane Xavier; Lapinlampi, Niina; Puhakka, Noora. 2019. Neurobiology of disease. 123: 42-58 A2 Review article, Literature review, Systematic review

Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies

Karttunen, J; Heiskanen, M; Lipponen, A; Poulsen, D; Pitkänen, A. 2019. International journal of molecular sciences. 20: 1259 A2 Review article, Literature review, Systematic review

Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2)

Anwer, M; Bolkvadze, T; Puhakka, N; Ndode-Ekane, XE; Pitkänen, A. 2019. Neuroscience. 415: 184-200 A1 Journal article (refereed), original research

Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Ndode-Ekane, XE; Santana-Gomez, C; Casillas-Espinosa, PM; Ali, I; Brady, RD; Smith, G; Andrade, P; Immonen, R; Puhakka, N; Hudson, MR; Braine, EL; Shultz, SR; Staba, RJ; O'Brien, TJ; Pitkänen, A. 2019. Epilepsy research. 151: 7-16 A1 Journal article (refereed), original research

Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis

Santana-Gomez, C; Andrade, P; Hudson, MR; Paananen, T; Ciszek, R; Smith, G; Ali, I; Rundle, BK; Ndode-Ekane, XE; Casillas-Espinosa, PM; Immonen, R; Puhakka, N; Jones, N; Brady, RD; Perucca, P; Shultz, SR; Pitkänen, A; O'Brien, TJ; Staba, R. 2019. Epilepsy research. 156: 106110 A1 Journal article (refereed), original research

Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis

Immonen, R; Smith, G; Brady, RD; Wright, D; Johnston, L; Harris, NG; Manninen, E; Salo, R; Branch, C; Duncan, D; Cabeen, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Shultz, SR; Andrade, P; Puhakka, N; Staba, RJ; O'Brien, TJ; et al.. 2019. Epilepsy research. 150: 46-57 A1 Journal article (refereed), original research

Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis

Casillas-Espinosa, PM; Andrade, P; Santana-Gomez, C; Paananen, T; Smith, G; Ali, I; Ciszek, R; Ndode-Ekane, XE; Brady, RD; Tohka, J; Hudson, MR; Perucca, P; Braine, EL; Immonen, R; Puhakka, N; Shultz, SR; Jones, NC; Staba, RJ; Pitkänen, A; O'Brien, TJ. 2019. Epilepsy research. 156: 106131 A1 Journal article (refereed), original research

In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury - Lessons Learned

Lipponen, A; Natunen, T; Hujo, M; Ciszek, R; Hämäläinen, E; Tohka, J; Hiltunen, M; Paananen, J; Poulsen, D; Kansanen, E; Ekolle Ndode-Ekane, X; Levonen, AL; Pitkänen, A. 2019. International journal of molecular sciences. 20: 5395 A1 Journal article (refereed), original research

Lateral fluid-percussion injury leads to pituitary atrophy in rats

Anwer, M; Immonen, R; Hayward, NMEA; Ndode-Ekane, XE; Puhakka, N; Gröhn, O; Pitkänen, A. 2019. Scientific reports. 9: 11819 A1 Journal article (refereed), original research

MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex - A 6-Months Multimodal Imaging Follow-Up Study

Yasmin, Amna; Pitkänen, Asla; Jokivarsi, Kimmo; Poutiainen, Pekka; Gröhn, Olli; Immonen, Riikka. 2019. Frontiers in neuroscience. 13: 863 A1 Journal article (refereed), original research

Preclinical common data elements (CDEs) for epilepsy: A joint ILAE/AES and NINDS translational initiative

Scharfman, Helen E; Galanopoulou, Aristea S; French, Jacqueline A; Pitkänen, Asla; Whittemore, Vicky; Harte-Hargrove, Lauren C. 2019. Epilepsia open. 3: 9-12 B1 Non-refereed journal articles

Preface - Practical and theoretical considerations for performing a multi-center preclinical biomarker discovery study of post-traumatic epileptogenesis: lessons learned from the EpiBioS4Rx consortium

Pitkänen, Asla; O'Brien, Terence J; Staba, Richard. 2019. Epilepsy research. 156: 1-4 A1 Journal article (refereed), original research

Visualization of thalamic calcium influx with quantitative susceptibility mapping as a potential imaging biomarker for repeated mild traumatic brain injury

Schweser, F; Kyyriäinen, J; Preda, M; Pitkänen, A; Toffolo, K; Poulsen, A; Donahue, K; Levy, B; Poulsen, D. 2019. Neuroimage. 200: 250-258 A1 Journal article (refereed), original research

Web Application for Quantification of Traumatic Brain Injury-Induced Cortical Lesions in Adult Mice

Ciszek, R; Andrade, P; Tapiala, J; Pitkänen, A; Ndode-Ekane, XE. 2019. Neuroinformatics. 2020; 18: 307-317 A1 Journal article (refereed), original research

A web-based application for generating 2D-unfolded cortical maps to analyze the location and extent of cortical lesions following traumatic brain injury in adult rats

Andrade, Pedro; Ciszek, Robert; Pitkänen, Asla; Ndode-Ekane, Xavier Ekolle. 2018. Journal of neuroscience methods. 308: 330-336 A1 Journal article (refereed), original research

Algorithm for automatic detection of spontaneous seizures in rats with post-traumatic epilepsy

Andrade, Pedro; Paananen, Tomi; Ciszek, Robert; Lapinlampi, Niina; Pitkänen, Asla. 2018. Journal of neuroscience methods. 307: 37-45 A1 Journal article (refereed), original research

Analytic Tools for Post-traumatic Epileptogenesis Biomarker Search in Multimodal Dataset of an Animal Model and Human Patients

Duncan, Dominique; Barisano, Giuseppe; Cabeen, Ryan; Sepehrband, Farshid; Garner, Rachael; Braimah, Adebayo; Vespa, Paul; Pitkänen, Asla; Law, Meng; Toga, Arthur W. 2018. Frontiers in neuroscience. 12: 86 A1 Journal article (refereed), original research

Big data sharing and analysis to advance research in post-traumatic epilepsy

Duncan, Dominique; Vespa, Paul; Pitkanen, Asla; Braimah, Adebayo; Lapinlampi, Niina; Toga, Arthur W. 2018. Neurobiology of disease. 2019; 123: 127-136 A2 Review article, Literature review, Systematic review

Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury

Huttunen, JK; Airaksinen, AM; Barba, C; Colicchio, G; Niskanen, JP; Shatillo, A; Sierra Lopez, A; Ndode-Ekane, XE; Pitkanen, A; Gröhn, O. 2018. Journal of neurotrauma. 35: 2708-2717 A1 Journal article (refereed), original research

Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study

Tubi, MA; Lutkenhoff, E; Blanco, MB; McArthur, D; Villablanca, P; Ellingson, B; Diaz-Arrastia, R; Van Ness, P; Real, C; Shrestha, V; Engel, J; Jr; Vespa, PM; Agoston, D; Au, A; Bell, MJ; Bleck, T; Branch, C; Buitrago Blanco, M; Bullock, R; Burrows, BT; et al.; EpiBioS4Rx Study Group Investigators (incl. Pitkänen, Asla). 2018. Neurobiology of disease. 2019; 123: 115-121 A2 Review article, Literature review, Systematic review

Epilepsy in neuropathologically verified Alzheimer's disease

Rauramaa, T; Saxlin, A; Lohvansuu, K; Alafuzoff, I; Pitkänen, A; Soininen, H. 2018. Seizure: european journal of epilepsy. 58: 9-12 A1 Journal article (refereed), original research

Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis

Kamnaksh, A; Puhakka, N; Ali, I; Smith, G; Aniceto, R; McCullough, J; Das Gupta, S; Ndode-Ekane, XE; Brady, R; Casillas-Espinosa, P; Hudson, M; Santana-Gomez, C; Immonen, R; Abreu, PA; Jones, N; Shultz, S; Staba, RJ; O'Brien, TJ; Agoston, D; Pitkänen, A. 2018. Epilepsy research. 2019; 149: 92-101 A1 Journal article (refereed), original research

Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Ciszek, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Smith, G; Puhakka, N; Lapinlampi, N; Andrade, P; Kamnaksh, A; Immonen, R; Paananen, T; Hudson, MR; Brady, RD; Shultz, SR; O'Brien, TJ; Staba, RJ; Tohka, J; Pitkänen, A. 2018. Epilepsy research. 2019; 150: 17-26 A1 Journal article (refereed), original research

Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs

Karttunen, Jenni; Heiskanen, Mette; Navarro-Ferrandis, Vicente; Das Gupta, Shalini; Lipponen, Anssi; Puhakka, Noora; Rilla, Kirsi; Koistinen, Arto; Pitkänen, Asla. 2018. Journal of extracellular vesicles. 2019; 8: 1555410 A1 Journal article (refereed), original research

Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein

Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A. 2018. Journal of comparative neurology. 526: 1806-1819 A1 Journal article (refereed), original research

T-cell infiltration into the perilesional cortex is long-lasting and associates with poor somatomotor recovery after experimental traumatic brain injury

Ndode-Ekane, Xavier Ekolle; Matthiesen, Liz; Bañuelos-Cabrera, Ivette; Palminha, Cátia Alexandra Pegas; Pitkänen, Asla. 2018. Restorative neurology and neuroscience. 36: 485-501 A1 Journal article (refereed), original research

Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury

Lipponen, Anssi; El-Osta, Assam; Kaspi, Antony; Ziemann, Mark; Khurana, Ishant; Harikrishnan, K N; Navarro-Ferrandis, Vicente; Puhakka, Noora; Paananen, Jussi; Pitkänen, Asla. 2018. Acta neuropathologica communications. 6: 17 A1 Journal article (refereed), original research

miR-124-3p is a chronic regulator of gene expression after brain injury

Vuokila, Niina; Lukasiuk, Katarzyna; Bot, Anna Maria; van Vliet, Erwin A; Aronica, Eleonora; Pitkänen, Asla; Puhakka Niina. 2018. Cellular and molecular life sciences. 75: 4557-4581 A1 Journal article (refereed), original research

Chronically dysregulated NOTCH1 interactome in the dentate gyrus after traumatic brain injury

Puhakka Noora, Bot Anna Maria, Vuokila Niina, Debski Konrad Jozef, Lukasiuk Katarzyna, Pitkänen Asla. 2017. PLoS ONE. 12: e0172521 A1 Journal article (refereed), original research

Common data elements for preclinical epilepsy research: Standards for data collection and reporting. A TASK3 report of the AES/ILAE Translational Task Force of the ILAE

Harte-Hargrove LC, French JA, Pitkänen A, Galanopoulou AS, Whittemore V, Scharfman HE. 2017. Epilepsia. 58: 78-86 A1 Journal article (refereed), original research

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks-Kayal AR, Engel J Jr, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D et al.. 2017. Epilepsia. 2018; 59: 37-66 A2 Review article, Literature review, Systematic review

Decreased levels of active uPA and KLK8 assessed by [111In]MICA-401 binding correlate with the seizure burden in an animal model of temporal lobe epilepsy

Missault S, Peeters L, Amhaoul H, Thomae D, Van Eetveldt A, Favier B, Thakur A, Van Soom J, Pitkänen A, Augustyns K, Joossens J, Staelens S, Dedeurwaerdere S. 2017. Epilepsia. 58: 1615-1625 A1 Journal article (refereed), original research

Generalized Seizures after Experimental Traumatic Brain Injury Occur at the Transition from Slow-Wave to Rapid-Eye-Movement Sleep

Andrade Pedro, Nissinen Jari, Pitkanen Asla. 2017. Journal of neurotrauma. 34: 1482-1487 A1 Journal article (refereed), original research

Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy

Srivastava, Prashant K; Roncon, Paolo; Lukasiuk, Katarzyna; Gorter, Jan A; Aronica, Eleonora; Pitkänen, Asla; Petretto, Enrico; Johnson, Michael R; Simonato, Michele. 2017. eNeuro. 4: 1-22 A1 Journal article (refereed), original research

Models of Seizures and Epilepsy (Second Edition)

Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL. 2017. . . Elsevier C2 Edited book, conference proceedings or special issue of a journal

Standardization procedure for plasma biomarker analysis in rat models of epileptogenesis: Focus on circulating microRNAs

van Vliet Erwin A, Puhakka Noora, Mills James D, Srivastava Prashant K, Johnson Michael R, Roncon Paolo, Das Gupta Shalini, Karttunen Jenni, Simonato Michele, Lukasiuk Katarzyna, Gorter Jan A, Aronica Eleonora, Pitkänen Asla. 2017. Epilepsia. 58: 2013-2024 A2 Review article, Literature review, Systematic review

Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models

Dingledine Raymond, Coulter Douglas A, Fritsch Brita, Gorter Jan A, Lelutiu Nadia, McNamara James, Nadler J Victor, Pitkänen Asla, Rogawski Michael A, Skene Pate, Sloviter Robert S, Wang Yu, Wadman Wytse J, Wasterlain Claude, Roopra Avtar. 2017. Scientific data. 4: 1-10 A1 Journal article (refereed), original research

Unfolded Maps for Quantitative Analysis of Cortical Lesion Location and Extent after Traumatic Brain Injury

Ndode-Ekane Xavier Ekolle, Kharatishvili Irina, Pitkänen Asla. 2017. Journal of neurotrauma. 34: 459-474 A1 Journal article (refereed), original research

What Can We Model?

Pitkänen A, Galanopoulou AS, Moshé SL, Buckmaster PS. Teoksessa: Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL(toim.) , 2017. Models of Seizures and Epilepsy (Second Edition). s. 1-3. Elsevier A3 Book section, Chapters in research books

What Do Models Model? What Needs to Be Modeled?

Galanopoulou AS, Pitkänen A, Buckmaster PS, Moshé SL. Teoksessa: Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL(toim.) , 2017. Models of Seizures and Epilepsy (Second Edition). s. 1107-1119. Elsevier A3 Book section, Chapters in research books

Advances in the development of biomarkers for epilepsy

Pitkänen A, Löscher W, Vezzani A, Becker AJ, Simonato M, Lukasiuk K, Gröhn O, Bankstahl JP, Friedman A, Aronica E, Gorter JA, Ravizza T, Sisodiya SM, Kokaia M, Beck H. 2016. The Lancet Neurology. 15: 843-856 A2 Review article, Literature review, Systematic review

Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44, and S100a4 as Treatment Targets

Lipponen Anssi, Paananen Jussi, Puhakka Noora, Pitkänen Asla. 2016. Scientific reports. 6: 31570 A1 Journal article (refereed), original research

Common data elements and data management: Remedy to cure underpowered preclinical studies

Lapinlampi N, Melin E, Aronica E, Bankstahl JP, Becker A, Bernard C, Gorter JA, Gröhn O, Lipsanen A, Lukasiuk K, Löscher W, Paananen J, Ravizza T, Roncon P, Simonato M, Vezzani A, Kokaia M, Pitkänen A. 2016. Epilepsy research. 129: 87-90 A1 Journal article (refereed), original research

Dynamics of PDGFRß Expression in Different Cell Types After Brain Injury

Kyyriäinen Jenni, Ndode-Ekane Xavier Ekkolle, Pitkänen Asla. 2016. Glia. 2017; 65: 322-341 A1 Journal article (refereed), original research

Epileptogenesis after traumatic brain injury in Plaur-deficient mice

Bolkvadze T, Puhakka N, Pitkänen A. 2016. Epilepsy and behavior. 60: 187-196 A1 Journal article (refereed), original research

Etiology matters - Genomic DNA methylation patterns in three rat models of acquired epilepsy

Debski KJ, Pitkanen A, Puhakka N, Bot AM, Khurana I, Harikrishnan KN, Ziemann M, Kaspi A, El-Osta A, Lukasiuk K, Kobow K. 2016. Scientific reports. 6: 25668 A1 Journal article (refereed), original research

Ex Vivo Tracing of NMDA and GABA-A Receptors in Rat Brain After Traumatic Brain Injury Using 18F-GE-179 and 18F-GE-194 Autoradiography

López-Picón F, Snellman A, Shatillo O, Lehtiniemi P, Grönroos TJ, Marjamäki P, Trigg W, Jones PA, Solin O, Pitkänen A, Haaparanta-Solin M. 2016. Journal of nuclear medicine. 57: 1442-1447 A1 Journal article (refereed), original research

Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents

Pirttimäki T, Salo RA, Shatillo A, Kettunen MI, Paasonen J, Sierra A, Jokivarsi K, Leinonen V, Andrade P, Quittek S, Pitkänen A, Gröhn O. 2016. Journal of neuroscience methods. 274: 154-163 A1 Journal article (refereed), original research

Increased Epileptiform EEG Activity and Decreased Seizure Threshold in Arctic APP Transgenic Mouse Model of Alzheimer's Disease

Ziyatdinova Sofya, Rönnbäck Annica, Gurevicius Kestutis, Miszczuk Diana, Graff Caroline, Winblad Bengt, Pitkänen Asla, Tanila Heikki. 2016. Current alzheimer research. 13: 817-830 A1 Journal article (refereed), original research

WONOEP appraisal: Imaging biomarkers in epilepsy

van Vliet EA, Dedeurwaerdere S, Cole AJ, Friedman A, Koepp MJ, Potschka H, Immonen R, Pitkänen A, Federico P. 2016. Epilepsia. 58: 315-330 A2 Review article, Literature review, Systematic review

Development of epilepsy after ischaemic stroke

Pitkänen Asla, Roivainen Reina, Luasiuk Katarzyna. 2015. The Lancet Neurology. 2016; 15: 185-197 A2 Review article, Literature review, Systematic review

Diffusion tensor imaging detects chronic microstructural changes in white and gray matter after traumatic brain injury in rat

Laitinen Teemu, Sierra Alejandra, Bolkvadze Tamuna, Pitkänen Asla, Gröhn Olli. 2015. Frontiers in neuroscience. 9: 12 p A1 Journal article (refereed), original research

Epilepsy biomarkers

Engel Jerome Jr, Pitkänen Asla. Teoksessa: Shorvon Simon D, Perucca Emilio, Engel Jerome Jr. (Eds.)(toim.) , 2015. Treatment of Epilepsy (4th Edition). s. 103-109. Wiley-Blackwell A3 Book section, Chapters in research books

Epilepsy priorities in Europe: A report of the ILAE-IBE Epilepsy Advocacy Europe Task Force

Baulac Michel, de Boer Hanneke, Elger Christian, Glynn Mike, Kälviäinen Reetta, Little Ann, Mifsud Janet, Perucca Emilio, Pitkänen Asla, Ryvlin Philippe. 2015. Epilepsia. [epub ahead of print 28 SEP 2015]: - A1 Journal article (refereed), original research

Epileptogenesis

Pitkänen Asla, Lukasiuk Katarzyna, Dudek F Edward, Staley Kevin J. 2015. Cold Spring Harbor perspectives in medicine. [epub ahead of print Sep 18, 2015]: a022822 A1 Journal article (refereed), original research

Epileptogenesis after traumatic brain injury in Plau-deficient mice

Bolkvadze Tamuna, Rantala Jukka, Puhakka Noora, Andrade Petro, Pitkänen Asla. 2015. Epilepsy and behavior. 51: 19-27 A1 Journal article (refereed), original research

Expression of PDGFR-beta positive NG2 cells in the hippocampus after status epilepticus

Kyyriäinen J., Ndode-Ekane X. E., Pitkänen A.. 2015. Glia

Imaging microstructural damage and plasticity in the hippocampus during epileptogenesis

Sierra A, Gröhn O, Pitkänen A. 2015. Neuroscience. 309: 162-172 A2 Review article, Literature review, Systematic review

Opportunities for improving animal welfare in rodent models of epilepsy and seizures

Lidster K, Jefferys JG, Blümcke I, Crunelli V, Flecknell P, Frenguelli BG, Gray WP, Kaminski R, Pitkänen A, Ragan I, Shah M, Simonato M, Trevelyan A, Volk H, Walker M, Yates N, Prescott MJ. 2015. Journal of neuroscience methods. 2016; 260: 2-25 A1 Journal article (refereed), original research

Reduction of epileptiform activity by valproic acid in a mouse model of Alzheimer's disease is not long-lasting after treatment discontinuation

Ziyatdinova Sofya, Viswanathan Jayashree, Hiltunen Mikko, Tanila Heikki, Pitkänen Asla. 2015. Epilepsy research. 112: 43-55 A1 Journal article (refereed), original research

Traumatic Brain Injury Increases the Expression of Nos1, Aß Clearance, and Epileptogenesis in APP/PS1 Mouse Model of Alzheimer's Disease

Miszczuk Diana, Debski Konrad J, Tanila Heikki, Lukasiuk Katarzyna, Pitkänen Asla. 2015. Molecular neurobiology. 2016; 53: 7010-7027 A1 Journal article (refereed), original research

Urokinase-type plasminogen activator deficiency has little effect on seizure susceptibility and acquired epilepsy phenotype but reduces spontaneous exploration in mice

Rantala J, Kemppainen S, Ndode-Ekane XE, Lahtinen V, Bolkvadze Tamuna, Gurevicius K, Tanila H, Pitkänen A. 2015. Epilepsy and behavior. 42: 117-128 A1 Journal article (refereed), original research

A common SCN1A splice-site polymorphism modifies the effect of carbamazepine on cortical excitability--a pharmacogenetic transcranial magnetic stimulation study

Menzler K, Hermsen A, Balkenhol K, Duddek C, Bugiel H, Bauer S, Schorge S, Reif PS, Klein KM, Haag A, Oertel WH, Hamer HM, Knake S, Trucks H, Sander T, Rosenow F; EPICURE-Consortium. 2014. Epilepsia. 2014 Feb;55(2): 362-9 A1 Journal article (refereed), original research

Are Alterations in Transmitter Receptor and Ion Channel Expression Responsible for Epilepsies?

Powell Kim L, Lukasiuk Katarzyna, O'Brien Terence J, Pitkänen Asla. Teoksessa: Helen E. Scharfman, Paul S. Buckmaster(toim.) , 2014. Issues in Clinical Epileptology: A View from the Bench. s. 211-29. Springer Science+Business Media A3 Book section, Chapters in research books

Brain Extracellular Matrix in Health and Disease

Dityatev A, Wehrle-Haller B, Pitkänen A. 2014. . . Elsevier C1 Book

Decreased resting functional connectivity after traumatic brain injury in the rat

Mishra Asht Mangal, Bai Xiaoxiao, Sanganahalli Basavaraju G, Waxman Stephen G, Shatillo Olena, Gröhn Olli, Hyder Fahmeed, Pitkänen Asla, Blumenfeld Hal. 2014. PLoS ONE. 2014 Apr 18;9(4): e95280 A1 Journal article (refereed), original research

Effect of lacosamide on structural damage and functional recovery after traumatic brain injury in rats

Pitkänen A, Immonen R, Ndode-Ekane X, Gröhn O, Stöhr T, Nissinen J. 2014. Epilepsy research. 2014 May;108(4): 653-65 A1 Journal article (refereed), original research

Epilepsy related to traumatic brain injury

Pitkänen Asla, Immonen Riitta. 2014. Neurotherapeutics. 11: 286-296 A2 Review article, Literature review, Systematic review

Expression of GABA receptor subunits in the hippocampus and thalamus after experimental traumatic brain injury

Drexel M, Puhakka N, Kirchmair E, Hörtnagl H, Pitkänen A, Sperk G. 2014. Neuropharmacology. 2014 Sep 16: pii: S0028-3908(14)00306-2 A1 Journal article (refereed), original research

Gender issues in antiepileptogenic treatments

Pitkänen A, Huusko N, Ndode-Ekane XE, Kyyriäinen J, Lipponen A, Lipsanen A, Sierra A, Bolkvadze T. 2014. Neurobiology of disease. 2014 Jun 6 ePub ahead of print: pii: S0969-9961(14)00163-6 A1 Journal article (refereed), original research

In response to commentary on cavernoma-related epilepsy: review and recommendations for management-report of the surgical task force of the ILAE commission on therapeutic strategies

Rosenow F, Alonso-Vanegas MA, Baumgartner C, Blümcke I, Carreño M, Gizewski ER, Hamer HM, Knake S, Kahane P, Lüders HO, Mathern GW, Menzler K, Miller J, Otsuki T, Ozkara C, Pitkänen A, Roper SN, Sakamoto AC, Sure U, Walker MC, Steinhoff BJ; Surgical Task Force, Commission on Therapeutic Strategies of the ILAE. 2014. Epilepsia. 55: 466-467 A1 Journal article (refereed), original research

Neural ECM and epilepsy

Pitkänen A, Ndode-Ekane XE, Lukasiuk K, Wilczynski GM, Dityatev A, Walker MC, Chabrol E, Dedeurwaerdere S, Vazquez N, Powell EM. 2014. Progress in brain research. 214: 229-62 A1 Journal article (refereed), original research

Parvalbumin immunoreactivity and expression of GABAA receptor subunits in the thalamus after experimental TBI

Huusko N, Pitkänen A. 2014. Neuroscience. : 30-45. A1 Journal article (refereed), original research

Past and Present Definitions of Epileptogenesis and Its Biomarkers

Pitkänen A, Engel J Jr. 2014. Neurotherapeutics. 2014 Apr;11(2): 231-41 A2 Review article, Literature review, Systematic review

Posttraumatic epilepsy - Disease or comorbidity?

Pitkänen Asla, Kemppainen Samuli, Ndode-Ekane Xavier Ekolle, Huusko Noora, Huttunen Joanna K, Gröhn Olli, Immonen Riikka, Sierra Alejandra, Bolkvadze Tamuna. 2014. Epilepsy and behavior. 2014 Feb 11.: -- A2 Review article, Literature review, Systematic review

The challenge and promise of anti-epileptic therapy development in animal models

Simonato Michele, Brooks-Kayal Amy R, Engel Jr Jerome, Galanopoulou Aristea S, Jensen Frances E, Moshé Solomon L, O'Brien Terence J, Pitkanen Asla, Wilcox Karen S, French Jacqueline A. 2014. The Lancet Neurology. 13: 949-60 A1 Journal article (refereed), original research

Cavernoma-related epilepsy: Review and recommendations for management-Report of the Surgical Task Force of the ILAE Commission on Therapeutic Strategies

Rosenow F, Alonso-Vanegas MA, Baumgartner C, Blümcke I, Carreño M, Gizewski ER, Hamer HM, Knake S, Kahane P, Lüders HO, Mathern GW, Menzler K, Miller J, Otsuki T, Ozkara C, Pitkänen A, Roper SN, Sakamoto AC, Sure U, Walker MC, Steinhoff BJ; Surgical Task Force, Commission on Therapeutic Strategies of the ILAE. 2013. Epilepsia. 2013 Dec;54(12):: 2025-35. A1 Journal article (refereed), original research

Diffusion tensor imaging of hippocampal network plasticity

Sierra A, Laitinen T, Gröhn O, Pitkänen A. 2013. Brain structure and function. 220: 781-801 A1 Journal article (refereed), original research

Epilepsy biomarkers

Engel J Jr, Pitkänen A, Loeb JA, Dudek FE, Bertram EH 3rd, Cole AJ, Moshé SL, Wiebe S, Jensen FE, Mody I, Nehlig A, Vezzani A. 2013. Epilepsia. 2013 Aug;54 Suppl 4: 61-69 A1 Journal article (refereed), original research

Epilepsy on the horizon

Epilepsy Advocacy Europe, Sheanon E, Pitkänen A. 2013. Epilepsia. 54: 1713-4 A1 Journal article (refereed), original research

Epilepsy therapy development: Technical and methodologic issues in studies with animal models

Galanopoulou AS, Kokaia M, Loeb JA, Nehlig A, Pitkänen A, Rogawski MA, Staley KJ, Whittemore VH, Edward Dudek F. 2013. Epilepsia. 2013 Aug;54 Suppl 4: 13-23 A1 Journal article (refereed), original research

Issues related to development of antiepileptogenic therapies

Pitkänen A, Nehlig A, Brooks-Kayal AR, Dudek FE, Friedman D, Galanopoulou AS, Jensen FE, Kaminski RM, Kapur J, Klitgaard H, Löscher W, Mody I, Schmidt D. 2013. Epilepsia. 2013 Aug;54 Suppl 4:: 35-43 A1 Journal article (refereed), original research

Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy

Huusko N, Römer C, Ndode-Ekane XE, Lukasiuk K, Pitkänen A. 2013. Brain structure and function. 2015; 220: 153-191 A1 Journal article (refereed), original research

MRI biomarkers for post-traumatic epileptogenesis.

Immonen R, Kharatishvili I, Gröhn O, Pitkänen A. 2013. Journal of neurotrauma. 2013 Jul 15;30(14): 1305-9 A1 Journal article (refereed), original research

Monitoring functional impairment and recovery after traumatic brain injury in rats by FMRI

Niskanen JP, Airaksinen AM, Sierra A, Huttunen JK, Nissinen J, Karjalainen PA, Pitkänen A, Gröhn OH. 2013. Journal of neurotrauma. : 546-56 A1 Journal article (refereed), original research

Targets for antiepileptogenesis: Overview

Pitkänen Asla. Teoksessa: Potschka H and Lerche H (eds.)(toim.) , 2013. Therapeutic targets and perspectives in the pharmacological treatment of epilepsy. s. 86-90. Uni-Med Verlag AG A3 Book section, Chapters in research books

Detection of Calcifications In Vivo and Ex Vivo after Brain Injury in Rat Using SWIFT

Lehto LJ, Sierra A, Corum CA, Zhang J, Idiyatullin D, Pitkänen A, Garwood M, Gröhn O. 2012. Neuroimage. 2012 Jul 16;61(4): 761-72 A1 Journal article (refereed), original research

Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease

Zilberter M, Ivanov A, Ziyatdinova S, Mukhtarov M, Malkov A, Alpár A, Tortoriello G, Botting CH, Fülöp L, Osypov AA, Pitkänen A, Tanila H, Harkany T, Zilberter Y. 2012. Journal of neurochemistry. : -- A1 Journal article (refereed), original research

Finding a better drug for epilepsy: Antiepileptogenesis targets

Kobow K, Auvin S, Jensen F, Löscher W, Mody I, Potschka H, Prince D, Sierra A, Simonato M, Pitkänen A, Nehlig A, Rho JM. 2012. Epilepsia. 2012 Nov;53(11): 1868-1876 A2 Review article, Literature review, Systematic review

Head Trauma and Epilepsy

Pitkänen Asla, Bolkvadze Tamuna. Teoksessa: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV(toim.) , 2012. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. s. 331-342. Oxford University Press A3 Book section, Chapters in research books

Identification of new epilepsy treatments: issues in preclinical methodology

Galanopoulou AS, Buckmaster PS, Staley KJ, Moshé SL, Perucca E, Engel J Jr, Löscher W, Noebels JL, Pitkänen A, Stables J, White HS, O'Brien TJ, Simonato M. 2012. Epilepsia. 2012 Mar;53(3): 571-82 A1 Journal article (refereed), original research

Molecular Basis of Acquired Epileptogenesis

Lukasiuk K, Pitkänen A. Teoksessa: Stefan H, Theodore W(toim.) , 2012. Handbook of clinical neurology: Epilepsy Part I: Basic Principles and Diagnosis. s. 3-12. Elsevier A3 Book section, Chapters in research books

New Insight on the Mechanisms of Epileptogenesis in the Developing Brain

Kubova H, Lukasiuk K, Pitkänen A. Teoksessa: Akalan Nejat, Di Rocco Concezio(toim.) , 2012. Pediatric Epilepsy Surgery. s. --. A3 Book section, Chapters in research books

Simultaneous BOLD fMRI and local field potential measurements during kainic acid-induced seizures

Airaksinen AM, Hekmatyar SK, Jerome N, Niskanen JP, Huttunen JK, Pitkänen A, Kauppinen RA, Gröhn OH. 2012. Epilepsia. 2012 Jul;53(7): 1245-53 A1 Journal article (refereed), original research

The Written Declaration on Epilepsy: An important achievement for Europe and beyond

Baulac M, De Boer H, Elger C, Glynn M, Kälviäinen R, Little A, Mifsud J, Perucca E, Pitkänen A. 2012. Seizure: european journal of epilepsy. 21: 75-76 A2 Review article, Literature review, Systematic review

Urokinase-Type Plasminogen Activator Receptor Modulates Epileptogenesis in Mouse Model of Temporal Lobe Epilepsy

Ndode-Ekane XE, Pitkänen A. 2012. Molecular neurobiology. : -- A1 Journal article (refereed), original research

Anti-epileptogenesis in rodent post-traumatic epilepsy models

Pitkänen Asla, Bolkvadze Tamuna, Immonen Riikka. 2011. Neuroscience letters. 497: 163-171 A2 Review article, Literature review, Systematic review

Development of Post-Traumatic Epilepsy after Controlled Cortical Impact and Lateral Fluid-Percussion-Induced Brain Injury in the Mouse.

Bolkvadze T, Pitkänen A. 2011. Journal of neurotrauma. 2012:29(5): 789-812 A1 Journal article (refereed), original research

Diffusion tensor MRI with tract-based spatial statistics and histology reveals undiscovered lesioned areas in kainate model of epilepsy in rat

Sierra Alejandra, Laitinen Teemu, Lehtimäki Kimmo, Rieppo Lassi, Pitkänen Asla, Gröhn Olli. 2011. Brain structure and function. 216: 123-135 A1 Journal article (refereed), original research

Magnetic resonance imaging of regional hemodynamic and cerebrovascular recovery after lateral fluid-percussion brain injury in rats

Hayward Nick Mark Edward Alexander, Tuunanen Pasi, Immonen Riikka, Ndode-Ekane Xavier Ekolle, Pitkänen Asla, Gröhn Olli. 2011. Journal of cerebral blood flow and metabolism. 31: 166-177 A1 Journal article (refereed), original research

Mechanisms of epileptogenesis and potential treatment targets

Pitkänen Asla, Lukasiuk Katarzyna. 2011. The Lancet Neurology. 10: 173-186 A2 Review article, Literature review, Systematic review

Molecular biomarkers of epileptogenesis

Pitkänen A, Lukasiuk K. 2011. Biomarkers in medicine. 5: 629-33 A1 Journal article (refereed), original research

Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain

Gröhn O, Sierra A, Immonen R, Laitinen T, Lehtimäki K, Airaksinen A, Hayward N, Nairismagi J, Lehto L, Pitkänen A. 2011. Epilepsia. : 57-60 B1 Non-refereed journal articles

Progressive loss of phasic, but not tonic, GABAA receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats

Pavlov I,Huusko N,Drexel M,Kirchmair E,Sperk G,Pitkänen A,Walker MC. 2011. Neuroscience. 194: 208-219 A1 Journal article (refereed), original research

Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels

Ziyatdinova Sofya, Gurevicius Kestutis, Kutchiashvili Nino, Bolkvadze Tamuna, Nissinen Jari, Tanila Heikki, Pitkänen Asla. 2011. Epilepsy research. 94: 75-85 A1 Journal article (refereed), original research

Association of chronic vascular changes with functional outcome after traumatic brain injury in rats

Hayward NM, Immonen R, Tuunanen PI, Ndode-Ekane XE, Gröhn O & Pitkänen A. 2010. Journal of neurotrauma. 27: 2203-2219 A1 Journal article (refereed), original research

Association of the severity of cortical damage with the occurrence of spontaneous seizures and hyperexcitability in an animal model of posttraumatic epilepsy

Kharatishvili I & Pitkänen A. 2010. Epilepsy research. 90: 47-59 A1 Journal article (refereed), original research

Diffusion tensor MRI of axonal plasticity in the rat hippocampus

Laitinen T, Sierra A, Pitkänen A & Gröhn O. 2010. Neuroimage. 51: 251-530 A1 Journal article (refereed), original research

Elevated cerebral blood flow and vascular density in the amygdala after status epilepticus in rats

Hayward NM, Ndode-Ekane XE, Kutchiashvili N, Gröhn O Pitkänen A.. 2010. Neuroscience letters. 484: 39-42 A1 Journal article (refereed), original research

Epileptogenesis after traumatic brain injury

Pitkänen A & Bolkvadze T. Teoksessa: (toim.) , 2010. Atlas of Epilepsies. s. 335-341. A3 Book section, Chapters in research books

Posttraumatic epilepsy

Kharatishvili I & Pitkänen A. 2010. Current opinion in neurology. 23: 183-188 A1 Journal article (refereed), original research

Simultaneous fMRI and local field potential measurements during epileptic seizures in medetomidine-sedated rats using raser pulse sequence

Airaksinen AM, Niskanen JP, Chamberlain R, Huttunen JK, Nissinen J, Garwood M, Pitkänen A & Gröhn O. 2010. Magnetic resonance in medicine. 64: 1191-1199 A1 Journal article (refereed), original research

Therapeutic approaches to epileptogenesis - hope on the horizon

Pitkänen A. 2010. EPILEPSIA. SUPPLEMENT. 3: 2-17 A2 Review article, Literature review, Systematic review

Urokinase-type plasminogen activator regulates neurodegeneration and neurogenesis but not vascular changes in the mouse hippocampus after status epilepticus

Lahtinen L, Ndode-Ekane XE, Barinka F, Akamine Y, Esmaeili MH, Rantala J & Pitkänen A. 2010. Neurobiology of disease. 37: 692-703 A1 Journal article (refereed), original research

Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy

Ndode-Ekane XE, Hayward N, Gröhn O & Pitkänen A. 2010. Neuroscience. 166: 312-332 A1 Journal article (refereed), original research

Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy

Minkeviciene R, Rheims S, Dobszay MB, Zilberter M, Hartikainen J, Fülöp L, Penke B, Zilberter Y, Harkany T, Pitkänen A, Tanila H. 2009. Journal of neuroscience. 29: 3453-3462 A1 Journal article (refereed), original research

Commentary: the prospect of cell-based therapy for epilepsy

Kriegstein AR, Pitkänen A. 2009. Neurotherapeutics. 6: 295-299 A2 Review article, Literature review, Systematic review

Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat - 11 months follow-up

Immonen RJ, Kharatishvili I, Niskanen J-P, Gröhn H, Pitkänen A, Gröhn OHJ. 2009. Experimental neurology. 215: 29-40 A1 Journal article (refereed), original research

Epilepsy: Neuronal Death

Pitkänen A, Lukasiuk K. Teoksessa: Squire LR(toim.) , 2009. Enclyclopedia of Neuroscience. Vol. 3. s. 1159-1166. Academid Press A3 Book section, Chapters in research books

Epileptogenesis alters gene expression pattern in rats subjected to amygdala-dependent emotional learning

Majak K, Dabrowski M, Pitkänen A. 2009. Neuroscience. 159: 468-482 A1 Journal article (refereed), original research

Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus

Lahtinen L, Huusko N, Myöhänen H, Lehtivarjo AK, Pellinen R, Turunen MP, Ylä-Herttuala S, Pirinen E, Pitkänen A. 2009. Neuroscience. 163: 316-328 A1 Journal article (refereed), original research

From traumatic brain injury to posttraumatic epilepsy: what animal models tell us about the process and treatment options

Pitkänen A, Immonen RJ, Gröhn OH, Kharatishvili I. 2009. EPILEPSIA. SUPPLEMENT. 50: 21-29 A2 Review article, Literature review, Systematic review

Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice

Marklund N, Morales D, Clausen F, Hånell A, Kiwanuka O, Pitkänen A, Gimbel DA, Philipson O, Lannfelt L, Hillered L, Strittmatter SM, McIntosh TK. 2009. Neuroscience. 163: 540-551 A1 Journal article (refereed), original research

Genes relevant to epileptogenic mechanisms

Maja K, Pitkänen A. Teoksessa: Avanzini G, Noebels J(toim.) , 2009. Genetics of Epilepsy and Genetic Epilepsies. s. 31-38. John Libbey Eurotext A3 Book section, Chapters in research books

Molecular and cellular basis of epileptogenesis in symptomatic epilepsy

Pitkänen A, Lukasiuk K. 2009. Epilepsy and behavior. 14: 16-25 A1 Journal article (refereed), original research

Neuropeptide Y overexpression using recombinant adeno-associated viral vectors

Noé F, Frasca A, Balducci C, Carli M, Sperk G, Ferraguti F, Pitkänen A, Bland R, Fitzsimons H, During M, Vezzani A. 2009. Neurotherapeutics. 6: 300-306 A1 Journal article (refereed), original research

Posttraumatic models

Kharatishvili I, Pitkänen A. Teoksessa: Schwartzkroin PA(toim.) , 2009. Encyclopedia of Basic Epilepsy Research. Vol. 3. s. 1229-1238. Academic Preess A3 Book section, Chapters in research books

Quantitative MRI predicts long-term structural and functional outcome after experimental traumatic brain injury

Immonen RJ, Kharatishvili I, Gröhn H, Pitkänen A, Gröhn OHJ. 2009. Neuroimage. 45: 1-9 A1 Journal article (refereed), original research

Quantitative T2 mapping as a potential marker for the initial assessment of the severity of damage after traumatic brain injury in rat

Kharatishvili I, Sierra A, Immonen RJ, Gröhn OHJ, Pitkänen A. 2009. Experimental neurology. 217: 154-164 A1 Journal article (refereed), original research

Seizure-induced gene expression

Pitkänen A, Lukasiuk K. Teoksessa: Schwartzkroin PA(toim.) , 2009. Encyclopedia of Basic Epilepsy Research. s. 1302-1309. Academic Press A3 Book section, Chapters in research books

Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus

Immonen RJ, Kharatishvili I, Sierra A, Einula C, Pitkänen A, Gröhn OH. 2008. Neuroimage. 40: 1718-1730 A1 Journal article (refereed), original research

Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy

Noè F, Pool AH, Nissinen J, Gobbi M, Bland R, Rizzi M, Balducci C, Ferraguti F, Sperk G, During MJ, Pitkänen A, Vezzani A. 2008. Brain. 131: 1506-1515 A1 Journal article (refereed), original research

Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat

Goffin K, Nissinen J, Van Laere K, Pitkänen A. 2007. Experimental neurology. 205: 501-505 A1 Journal article (refereed), original research

Diazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocamus-depend learning

Siiskonen H, Oikari S, Korhonen V-P, Pitkänen A, Voikar V, Kettunen M, Hakumäki J, Wahlfors T, Pussinen R, Penttonen M, Kiehne K, Kaasinen SK, Alhonen L, Jänne J, Herzig K-H. 2007. Molecular and cellular neuroscience. 34: 199-208 A1 Journal article (refereed), original research

Effect of antiepileptic drugs on spontaneous seizures in epileptic rats

Nissinen J, Pitkänen A. 2007. Epilepsy research. 73: 181-191 A1 Journal article (refereed), original research

Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat

Pitkänen A, Mathiesen C, Rønn LCB, Møller A, Nissinen J. 2007. Epilepsy research. 74: 45-54 A1 Journal article (refereed), original research

Epileptogenesis after cortical photothrombotic brain lesion in rats

Karhunen H, Bezvenyuk Z, Nissinen J, Sivenius J, Jolkkonen J, Pitkänen A, Sivenius J. 2007. Neuroscience. 148: 314-324 A1 Journal article (refereed), original research

Epileptogenesis in experimental models

Pitkänen A, Kharatisvili I, Karhunen H, Lukasiuk K, Immonen R, Nairismägi J, Gröhn O, Nissinen J. 2007. EPILEPSIA. SUPPLEMENT. 48: 13-20 A1 Journal article (refereed), original research

Gene therapy in epilepsy: The focus on NPY

Noe' F, Nissinen J, Pitkänen A, Gobbi M, Sperk G, During M, Vezzani A. 2007. Peptides. 28: 377-383 A2 Review article, Literature review, Systematic review

Genetics of epilepsy: epilepsy research foundation workshop report

Sisodiya S, Cross JH, Blümcke I, Chadwick D, Craig J, Crino PB, Debenham P, Delanty N, Elmslie F, Gardiner M, Golden J, Goldstein D, Greenberg DA, Guerrini R, Hanna M, Harris J, Harrison P, Johnson MR, Kirov G, Kullman DM, Makoff A, Marini C. 2007. Epileptic disorders. 9: 194-236 A1 Journal article (refereed), original research

Increased expression of caspase 2 in experimental and human temporal lobe epilepsy

Narkilahti S, Jutila L, Alafuzoff I, Karkola K, Paljärvi L, Immonen A, Vapalahti M, Mervaala E, Kälviäinen R, Pitkänen A. 2007. Neuromolecular medicine. 9: 129-144 A1 Journal article (refereed), original research

Magnetic resonance imaging in animal models of epilepsy-noninvasive detection of structural alterations

Gröhn O, Pitkänen A. 2007. EPILEPSIA. SUPPLEMENT. 48: 3-10 A1 Journal article (refereed), original research

Mechanisms of emotional learning in normal and epileptic brain

Majak K, Pitkänen A. Teoksessa: Natsume K, Hanazawa A, Miki T(toim.) , 2007. Brain-Inspired IT III. s. 22-27. Elsevier A4 Conference proceedings

Neuroprotection with anti-epileptic drugs: state of the evidence

Pitkänen A. Teoksessa: Trimble MR(toim.) , 2007. Seizure Freedom: Clinical, Research and Quality of Life Perspectives. s. 9-27. Clarius Press A3 Book section, Chapters in research books

Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis

Kharatishvili I, Immonen R, Gröhn O, Pitkänen A. 2007. Brain. 130: 3155-3168 A1 Journal article (refereed), original research

The novel antiepileptic agent RWJ-333369-A, but not its analog RWJ-333369, reduces regional cerebral edema without affecting neurobehavioral outcome or cell death following experimental traumatic brain injury

Keck CA, Thompson HJ, Pitkänen A, LeBold DG, Morales DM, Plevy JB, Puri R, Zhao B, Dichter M, McIntosh TK. 2007. Restorative neurology and neuroscience. 25: 77-90 A1 Journal article (refereed), original research

A long-term video-EEG and behavioral follow-up after endothelin-1 induced middle cerebral artery occlusion in rats

Karhunen H, Nissinen J, Sivenius J, Jolkkonen J, Pitkänen A. 2006. Epilepsy research. 72: 25-38 A1 Journal article (refereed), original research

A model of posttraumatic epilepsy induced by lateral fluid-percussion brain injury in rats

Kharatishvili I, Nissinen JP, McIntosh TK, Pitkänen A. 2006. Neuroscience. 140: 685-697 A1 Journal article (refereed), original research

Animal models of post-traumatic epilepsy

Pitkänen A, Mcintosh TK. 2006. Journal of neurotrauma. 23: 241-261 A1 Journal article (refereed), original research

Change over of the baton

Pitkänen A, Gilliam F. 2006. Epilepsy research

Chapter 11 Epileptogenesis-related genes revisited

Lukasiuk K, Dabrowski M, Adach A, Pitkänen A. 2006. Progress in brain research. 158: 223-241 A1 Journal article (refereed), original research

Cystatin C expression is increased in the hippocampus following photothrombotic stroke in rat

Pirttilä TJ, Pitkänen A. 2006. Neuroscience letters. 395: 108-113 A1 Journal article (refereed), original research

Fear conditioning is impaired in systemic kainic acid and amygdala-stimulation models of epilepsy

Kemppainen EJS, Nissinen J, Pitkänen A. 2006. Epilepsia. 47: 820-829 A1 Journal article (refereed), original research

Increased expression and activity of urokinase-type plasminogen activator during epileptogenesis

Lahtinen L, Lukasiuk K, Pitkänen A. 2006. European journal of neuroscience. 24: 1935-1945 A1 Journal article (refereed), original research

Manganese-enhanced magnetic resonance imaging of mossy fiber plasticity in vivo

Nairismägi J, Pitkänen A, Narkilahti S, Huttunen J, Kauppinen RA, Gröhn OHJ. 2006. Neuroimage. 30: 130-135 A1 Journal article (refereed), original research

New data suggest that discontinuation of status epilepticus is not necessary for antiepileptogenic effect in immature brain

Pitkänen A. 2006. Epilepsy currents

Status epilepticus in 12-day-old rats leads to temporal lobe neurodegeneration and volume reduction: A histologic and MRI study

Nairismägi J, Pitkänen A, Kettunen MI, Kauppinen RA, Kubova H. 2006. Epilepsia. 47: 479-488 A1 Journal article (refereed), original research

Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat

Pitkänen A, Kharatishvili I, Narkilahti S, Lukasiuk K, Nissinen J. 2005. Epilepsy research. 63: 27-42 A1 Journal article (refereed), original research

Caspase 6 expression in the rat hippocampus during epileptogenesis and epilepsy

Narkilahti S, Pitkänen A. 2005. Neuroscience. 131: 887-897 A1 Journal article (refereed), original research

Cystatin C expression is associated with granule cell dispersion in epilepsy

Pirttilä TJ, Manninen A, Jutila L, Nissinen J, Kälviäinen R, Vapalahti M, Immonen A, Paljärvi L, Karkola K, Alafuzoff I, Mervaala E, Pitkänen A. 2005. Annals of neurology. 58: 211-223 A1 Journal article (refereed), original research

Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse

Pirttilä TJ, Lukasiuk K, Håkansson K, Grubb A, Abrahamson M, Pitkänen A. 2005. Neurobiology of disease. 20: 241-253 A1 Journal article (refereed), original research

Epileptic seizure detection: A nonlinear viewpooint

Päivinen N, Lammi S, Pitkänen A, Nissinen J, Penttonen M, Grönfors T. 2005. Computer methods and programs in biomedicine. 79: 151-159 A1 Journal article (refereed), original research

Epileptogenesis after experimental focal cerebral ischemia

Karhunen H, Jolkkonen J, Sivenius J, Pitkänen A. 2005. Neurochemical research. 30: 1529-1542 A1 Journal article (refereed), original research

Experimental febrile seizures require an undetermined factor for induction of hippocampal sclerosis in immature rat brain

Pitkänen A, Gröhn O. 2005. Epilepsy currents

Experimental models of traumatic brain injury: Do we really need to build a better mousetrap?

Morales DM, Marklund N, Lebold D, Thompson HJ, Pitkanen A, Maxwell WL, Longhi L, Laurer H, Maegele M, Neugebauer E, Graham DI, Stocchetti N, McIntosh TK. 2005. Neuroscience. 136: 971-989 A1 Journal article (refereed), original research

Hippocampal damage in newly diagnosed focal epilepsy: a prospective MRI study

Salmenperä T, Könönen M, Roberts N, Vanninen R, Pitkänen A, Kälviäinen R, Könönen M. 2005. Neurology. 64: 62-68 A1 Journal article (refereed), original research

MR volumetric analysis of the piriform cortex and cortical amygdala in drug-refractory temporal lobe epilepsy

Goncalves Pereira PM, Insausti R, Artacho-Pérula E, Salmenperä T, Kälviäinen R, Pitkänen A. 2005. American journal of neuroradiology. 26: 319-332 A1 Journal article (refereed), original research

Antiepileptic drugs in neuroprotections

Pitkänen A, Kubova H. 2004. Expert opinion on pharmacotherapy. 5: 777-798 A1 Journal article (refereed), original research

Atipamezole, an alfa2-adrenoceptor antagonist, has disease modifying effects on epileptogenesis in rats

Pitkänen A, Narkilahti S, Bezvenyuk Z, Haapalinna A, Nissinen J. 2004. Epilepsy research. 61: 119-140 A1 Journal article (refereed), original research

Brain-derived neurotrophic factor signaling modifies hippocampal gene expression during epileptogenesis in transgenic mice

Lähteinen S, Pitkänen A, Knuuttila J, Törönen P, Castrén E. 2004. European journal of neuroscience. 19: 3245-3254 A1 Journal article (refereed), original research

Damage to the amygdalo-hippocampal projection in temporal lobe epilepsy: A tract-tracing study in chronic epileptic rats

Kemppainen S, Pitkänen A. 2004. Neuroscience. 126: 485-501 A1 Journal article (refereed), original research

Denervation and reinnervation of amygdaloid neurons in drug-refratory temporal lobe epilepsy

Pitkänen A. 2004. Epilepsy currents

Do seizures cause irreversible cognitive damage? Evidence from animal studies

Majak K, Pitkänen A. 2004. EPILEPSY & BEHAVIOR. SUPPLEMENT. 5: S35-S44 A1 Journal article (refereed), original research

Effect of lamotrigine treatment on epileptogenesis: an experimental study in rat

Nissinen J, Large CH, Stratton SC, Pitkänen A. 2004. Epilepsy research. 58: 119-132 A1 Journal article (refereed), original research

Electrophysiologic changes in the lateral and basal amygdaloid nuclei in temporal lobe epilepsy: an in vitro study in epileptic rats

Niittykoski M, Nissinen J, Penttonen M, Pitkänen A. 2004. Neuroscience. 124: 269-281 A1 Journal article (refereed), original research

Large-scale analysis of gene expression in epilepsy reseach: is synthesis alreasy possible?

Lukasiuk K, Pitkänen A. 2004. Neurochemical research. 29: 1169-1178 A2 Review article, Literature review, Systematic review

New pharmacotherapy for epilepsy

Pitkänen A. 2004. Idrugs. 7: 471-477 A2 Review article, Literature review, Systematic review

Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepy

Nairismägi J, Gröhn OHJ, Kettunen MI, Nissinen J, Kauppinen RA, Pitkänen A. 2004. Epilepsia. 45: 1024-1034 A1 Journal article (refereed), original research

Projections from the amygdaloid complex to the piriform cortex: A PHA-L study in the rat

Majak K, Rönkkö S, Kemppainen S, Pitkänen A. 2004. Journal of comparative neurology. 476: 414-428 A1 Journal article (refereed), original research

Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis

Kubová H, Mares P, Suchomelová L, Brozek G, Druga R, Pitkänen A. 2004. European journal of neuroscience. 19: 3255-3265 A1 Journal article (refereed), original research

Activation of the amygdalo-entorhinal pathway in fear-conditioning in rat

Majak K, Pitkänen A. 2003. European journal of neuroscience. 18: 1652-1659 A1 Journal article (refereed), original research

Administration of caspase 3 inhibitor during and after status epilepticus in rat: effect on neuronal damage and epileptogenesis

Narkilahti S, Nissinen J, Pitkänen A. 2003. Neuropharmacology. 44: 1068-1088 A1 Journal article (refereed), original research

American Epilepsy Society - 56th Annual Meeting

Pitkänen A. 2003. Idrugs

Assignment of 1H nuclear magnetic resonance visible polyunsaturated fatty acids in BT4C gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death

Griffin JL, Lehtimäki KK, Valonen PK, Gröhn OHJ, Kettunen MI, Ylä-Herttuala S, Pitkänen A, Nicholson JK, Kauppinen RA. 2003. Cancer research. 63: 3195-3201 A1 Journal article (refereed), original research

Clinical trials in neuroprotection

Pitkänen A. 2003. Idrugs. 6: 200-202 A1 Journal article (refereed), original research

Do epileptic seizures damage the brain?

Sutula TP, Hagen J, Pitkänen A. 2003. Current opinion in neurology. 16: 189-195 A1 Journal article (refereed), original research

Exacerbated status epilepticus and acute cell loss, but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signaling

Lähteinen S, Pitkänen A, Koponen E, Saarelainen T, Castrén E. 2003. Neuroscience. 122: 1081-1092 A1 Journal article (refereed), original research

Expression and activation of caspase 3 following status epilepticus in the rat

Narkilahti S, Pirttilä TJ, Lukasiuk K, Tuunanen J, Pitkänen A. 2003. European journal of neuroscience. 18: 1486-1496 A1 Journal article (refereed), original research

Intrinsic synaptic circuitry of the amygdala

Pitkänen A, Savander M, Nurminen N, Ylinen A. 2003. Annals of the New York Academy of Sciences. 985: 34-49 A1 Journal article (refereed), original research

Long-term functional consequences of transient occlusion of the middle cerebral artery in rats: a 1-year follow-up of the development of epileptogenesis and memory impairment in relation to sensorimotor deficits

Karhunen H, Pitkänen A, Virtanen T, Gureviciene I, Pussinen R, Ylinen A, Sivenius J, Nissinen J, Jolkkonen J. 2003. Epilepsy research. 54: 1-10 A1 Journal article (refereed), original research

Projections from the periamygdaloid cortex to the amygdaloid complex, the hippocampal formation, and the parahippocampal region: A PHA-L study in the rat

Majak K, Pitkänen A. 2003. Hippocampus. 13: 922-942 A1 Journal article (refereed), original research

Selective changes in gamma-aminobutyric acid type A receptor subunits in the hippocampus in spontaneously seizing rats with chronic temporal lobe epilepsy

Laurén HB, Pitkänen A, Nissinen J, Soini SL, Korpi ER, Holopainen IE. 2003. Neuroscience letters. 349: 58-62 A1 Journal article (refereed), original research

The Amygdala in Brain Function: Basic and Clinical Approaches

Shinnick-Gallagher P, Pitkänen A, Shekhar A, Cahill L. 2003. Annals of the New York Academy of Sciences. . New York Academy of Sciences C2 Edited book, conference proceedings or special issue of a journal

Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: summary of the NIH/NINDS/AES models II workshop

Stables JP, Bertram E, Dudek FE, Holmes G, Mathern G, Pitkanen A, White HS. 2003. Epilepsia. 44: 1472-1478 A1 Journal article (refereed), original research

Tunteiden neurobiologiaa

Pitkänen A. 2003. Duodecim. 119: 1471-1478 A1 Journal article (refereed), original research

cDNA profiling of epileptogenesis in the rat brain

Lukasiuk K, Kontula L, Pitkänen A. 2003. European journal of neuroscience. 17: 271-279 A1 Journal article (refereed), original research

Comparison of the distribution of calcium-binding proteins and intrinsic connectivity in the lateral nucleus of the rat, monkey, and human amygdala

Pitkänen A, Kemppainen S. 2002. Pharmacology biochemistry and behavior. 71: 369-377 A1 Journal article (refereed), original research

Decreased BDNF signalling in transgenic mice reduces epileptogenesis

Lähteinen S, Pitkänen A, Saarelainen T, Nissinen J, Koponen E, Castrén E. 2002. European journal of neuroscience. 15: 721-734 A1 Journal article (refereed), original research

Drug-mediated neuroprotection and anti-epileptogenesis

Pitkänen A. 2002. NEUROLOGY. SUPPLEMENT. 59: S27-S33 A1 Journal article (refereed), original research

Dynamic changes of status epilepticus-induced neuronal degeneration in the mediodorsal nucleus of the thalamus during postnatal development of the rat

Kubová H, Druga R, Haugvicová R, Suchomelová L, Pitkanen A. 2002. EPILEPSIA. SUPPLEMENT. 43: 54-60 A1 Journal article (refereed), original research

Efficacy of current antiepileptics to prevent neurodegeneration in epilepsy models

Pitkänen A. 2002. Epilepsy research. 50: 141-160 A1 Journal article (refereed), original research

Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy

Pitkänen A, Sutula TP. 2002. The Lancet Neurology. 1: 173-181 A1 Journal article (refereed), original research

Neurobiology of epileptogenesis in the temporal lobe

Jutila L, Immonen A, Partanen K, Partanen J, Mervaala E, Ylinen A, Alafuzoff I, Paljärvi L, Karkola K, Vapalahti M, Pitkänen A. Teoksessa: Pickard JD, Dolenc VV, Antunes JL, Reulen H-J, Sindou M, Strong AJ, de Tribolet N, Tulleken CAF, Vapalahti M(toim.) , 2002. Advances and Technical Standards in Neurosurgery. s. 3-22. Springer A3 Book section, Chapters in research books

Prevention of epileptogenesis

Pitkänen A. Teoksessa: Levy RH, Mattson RH, Meldrum BS, Perucca E(toim.) , 2002. Antiepileptic Drugs. s. 169-176. Lippincott A3 Book section, Chapters in research books

Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy

Pitkänen A, Nissinen J, Nairismägi J, Lukasiuk K, Gröhn OHJ, Miettinen R, Kauppinen R. Teoksessa: Sutula T, Pitkänen A(toim.) , 2002. Do Seizures Damage the Brain. s. 67-83. Elsevier A3 Book section, Chapters in research books

Projections from the amygdaloid complex to the claustrum and the endopiriform nucleus: a Phaseolus vulgaris leucoagglutinin study in the rat

Majak K, Pikkarainen M, Kemppainen S, Jolkkonen E, Pitkänen A. 2002. Journal of comparative neurology. 451: 236-249 A1 Journal article (refereed), original research

Projections from the amygdaloid complex to the magnocellular cholinergic basal forebrain in rat

Jolkkonen E, Miettinen R, Pikkarainen M, Pitkänen A. 2002. Neuroscience. 111: 133-149 A1 Journal article (refereed), original research

Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the entorhinal cortex in the macaque monkey

Pitkanen A, Kelly JL, Amaral DG. 2002. Hippocampus. 12: 186-205 A1 Journal article (refereed), original research

Projections from the posterior cortical nucleus of the amygdala to the hippocampal formation and parahippocampal region in rat

Kemppainen S, Jolkkonen E, Pitkänen A. 2002. Hippocampus. 12: 735-755 A1 Journal article (refereed), original research

Upregulation of cystatin C expression in the rat hippocampus during epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy

Lukasiuk K, Pirttilä TJ, Pitkänen A. 2002. EPILEPSIA. SUPPLEMENT. 43: 137-145 A1 Journal article (refereed), original research

Chronic elevation of brain GABA levels beginning two days after status epilepticus does not prevent epileptogenesis in rats

Halonen T, Nissinen J, Pitkänen A. 2001. Neuropharmacology. 40: 536-550 A1 Journal article (refereed), original research

Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat

Halonen T, Nissinen J, Pitkanen A. 2001. Epilepsy research. 46: 205-223 A1 Journal article (refereed), original research

Ex vivo MR microimaging of neuronal damage after kainate-induced status epilepticus in rat: correlation with quantitative histology

Pirttilä T-RM, Pitkänen A, Tuunanen J, Kauppinen RA. 2001. Magnetic resonance in medicine. 46: 946-954 A1 Journal article (refereed), original research

Hippocampal and amygdaloid damage in partial epilepsy A cross-sectional MRI study of 241 patients

Salmenperä T, Kälviäinen R, Partanen K, Pitkänen A. 2001. Epilepsy research. 46: 69-82 A1 Journal article (refereed), original research

Interconnectivity between the amygdaloid complex and the amygdalostriatal transition area: a PHA-L study in rat

Jolkkonen E, Pikkarainen M, Kemppainen S, Pitkänen A. 2001. Journal of comparative neurology. 431: 39-58 A1 Journal article (refereed), original research

Is mossy fiber sprouting present at the time of the first spontaneous seizures in rat experimental temporal lobe epilepsy?

Nissinen J, Lukasiuk K, Pitkänen A. 2001. Hippocampus. 11: 299-310 A1 Journal article (refereed), original research

MR volumetry of the entorhinal, perirhinal, and temporopolar cortices in drug-refractory temporal lobe epilepsy

Jutila L, Ylinen A, Partanen K, Alafuzoff I, Mervaala E, Partanen J, Vapalahti M, Vainio P, Pitkänen A. 2001. American journal of neuroradiology. 22: 1490-1501 A1 Journal article (refereed), original research

More evidence for seizure-induced neuron loss: is hippocampal sclerosis both cause and effect of epilepsy?

Sutula TP, Pitkänen A. 2001. Neurology. 57: 169-170 A1 Journal article (refereed), original research

Neurobiology of epileptogenesis in the temporal lobe

Jutila L, Immonen A, Partanen K, Partanen J, Mervaala E, Ylinen A, Alafuzoff I, Paljärvi L, Karkola K, Vapalahti M, Pitkänen A. Teoksessa: Pickard JD, Dolenc VV, Lobo Antunes J, Reulen H-J, Sindou M, Strong AJ, de Tribolet N, Tulleken CAF, Vapalahti M(toim.) , 2001. Advances and Technical Standards in Neurosurgery. s. 4-22. Springer A3 Book section, Chapters in research books

Projections from the amygdalo-piriform transition area to the amygdaloid coplex: A PHA-L study in rat

Jolkkonen E, Miettinen R, Pitkänen A. 2001. Journal of comparative neurology. 432: 440-465 A1 Journal article (refereed), original research

Projections from the lateral, basal and accessory basal nuclei of the amygdala to the perirhinal and postrhinal cortices in rat

Pikkarainen M, Pitkanen A. 2001. Cerebral cortex. 11: 1064-1082 A1 Journal article (refereed), original research

Status epilepticus causes necrotic damage in the mediodorsal nucleus of the thalamus in immature rats

Kubová H, Druga R, Lukasiuk K, Suchomelová L, Haugvicová R, Jirmanová I, Pitkänen A. 2001. Journal of neuroscience. 21: 3593-3599 A1 Journal article (refereed), original research

Time course and mechanisms of amygdaloid damage after kainate-induced status epilepticus in rat

Lukasiuk K, Tuunanen J, Halonen T, Pitkänen A. Teoksessa: Turski L, Schoepp DD, Cavalheiro EA(toim.) , 2001. Excitatory Amino Acids: Ten Years Later. s. 289-297. IOS A3 Book section, Chapters in research books

A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat

Nissinen J, Halonen T, Koivisto E, Pitkänen A. 2000. Epilepsy research. 38: 177-205 A1 Journal article (refereed), original research

Anatomic heterogeneity of the rat amygdaloid complex

Pitkänen A, Jolkkonen E, Kemppainen S. 2000. Folia morphologica. 59: 1-23 A2 Review article, Literature review, Systematic review

Association between the density of mossy fiber sprouting and seizure frequency in experimental and human temporal lobe epilepsy

Pitkänen A, Nissinen J, Lukasiuk K, Jutila L, Paljärvi L, Salmenperä T, Karkola K, Vapalahti M, Ylinen A. 2000. EPILEPSIA. SUPPLEMENT. 41: S24-S29 A1 Journal article (refereed), original research

Connectivity of the rat amygdaloid complex

Pitkänen A. Teoksessa: Aggleton JP(toim.) , 2000. The Amygdala. A Functional Analysis. s. 31-115. Oxford University Press A3 Book section, Chapters in research books

Distribution of parvalbumin, calretinin, and calbindin-D28k immunoreactivity in the rat amygdaloid complex and colocalization with gamma-aminobutyric acid

Kemppainen S, Pitkänen A. 2000. Journal of comparative neurology. 426: 441-467 A1 Journal article (refereed), original research

Do seizures cause neuronal damage in rat amygdala kindling?

Tuunanen J, Pitkänen A. 2000. Epilepsy research. 39: 171-176 A1 Journal article (refereed), original research

Early detection of irreversible cerebral ischemia in the rat using dispersion of the magnetic resonance imaging relaxation time, T1rho

Gröhn OHJ, Kettunen MI, Mäkelä HI, Penttonen M, Pitkänen A, Lukkarinen JA, Kauppinen RA. 2000. Journal of cerebral blood flow and metabolism. 20: 1457-1466 A1 Journal article (refereed), original research

GABA(A)-mediated toxicity of hippocampal neurons in vitro

Lukasiuk K, Pitkänen A. 2000. Journal of neurochemistry. 74: 2445-2454 A1 Journal article (refereed), original research

MRI volumetry of the hippocampus, amygdala, entorhinal cortex, and perirhinal cortex after status epilepticus

Salmenperä T, Kälviäinen R, Partanen K, Mervaala E, Pitkänen A. 2000. Epilepsy research. 40: 155-170 A1 Journal article (refereed), original research

Morphology of spiny neurons in the human entorhinal cortex: intracellular filling with lucifer yellow

Mikkonen M, Pitkänen A, Soininen H, Alafuzoff I, Miettinen R. 2000. Neuroscience. 96: 515-522 A1 Journal article (refereed), original research

Projections from the central nucleus of the amygdala to the gastric related area of the dorsal vagal complex: a Phaseolus vulgaris-leucoagglutinin study in rat

Liubashina O, Jolkkonen E, Pitkänen A. 2000. Neuroscience letters. 291: 85-88 A1 Journal article (refereed), original research

Quantitative MRI volumetry of the entorhinal cortex in temporal lobe epilepsy

Salmenperä T, Kälviäinen R, Partanen K, Pitkänen A. 2000. Seizure: european journal of epilepsy. 9: 208-215 A1 Journal article (refereed), original research

Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat: a review

Pitkänen A, Pikkarainen M, Nurminen N, Ylinen A. 2000. Annals of the New York Academy of Sciences. 911: 369-391 A2 Review article, Literature review, Systematic review

[11C]Flumazenil binding in the medical temporal lobe in patients with temporal lobe epilepsy. Correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology

Lamusuo S, Pitkänen A, Jutila L, Ylinen A, Partanen K, Kälviäinen R, Ruottinen H-M, Oikonen V, Någren K, Lehikoinen P, Vapalahti M, Vainio P, Rinne JO. 2000. Neurology. 54: 2252-2260 A1 Journal article (refereed), original research

Distribution of GABAergic cells and fibers in the hippocampal formation of the macaque monkey: an immunohistochemical and in situ hybridization study

Jongen-Rêlo AL, Pitkänen A, Amaral DG. 1999. Journal of comparative neurology. 408: 237-271 A1 Journal article (refereed), original research

Do GABAergic circuitries play a critical role in the regulation of seizure-induced neuronal damage and synaptic reorganization in the rat hippocampus?

Pitkänen A, Jolkkonen J. 1999. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY. SUPPLEMENT. : 443-449 A1 Journal article (refereed), original research

Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus

Pitkänen A, Nissinen J, Jolkkonen E, Tuunanen J, Halonen T. 1999. Epilepsy research. 33: 67-85 A1 Journal article (refereed), original research

Epilepsian geenit ja neurobiologia

Lehesjoki A-E, Pitkänen A. 1999. Duodecim. 115: 583-594 A1 Journal article (refereed), original research

Neuroprotective effect of remacemide hydrochloride in a perforant pathway stimulation model of status epilepticus in the rat

Halonen T, Nissinen J, Pitkänen A. 1999. Epilepsy research. 34: 251-269 A1 Journal article (refereed), original research

Prevention of seizure-induced neuronal damage and intellectual deterioration: experimental aspects and clinical implications

Kälviäinen R, Pitkänen A. Teoksessa: Sillanpää M, Gram L, Johannessen SI, Tomson T(toim.) , 1999. Epilepsy and Mental Retardation. s. 165 - 178. Wrightson Biomedical Publishing A3 Book section, Chapters in research books

Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the hippocampal formation in rat

Pikkarainen M, Rönkkö S, Savander V, Insausti R, Pitkänen A. 1999. Journal of comparative neurology. 403: 229-260 A1 Journal article (refereed), original research

Quantitative magnetic resonance imaging assessment of cerebral ischemia in rat using on-resonance T1 in the rotating frame

Gröhn OHJ, Lukkarinen JA, Silvennoinen MJ, Pitkänen A, van Zijl PCM, Kauppinen RA. 1999. Magnetic resonance in medicine. 42: 268-276 A1 Journal article (refereed), original research

Seizure-induced damage to the medial temporal lobe in temporal lobe epilepsy

Pitkänen A, Salmenperä T, Äikiä M, Partanen K, Kälviäinen R. Teoksessa: Sillanpää M, Gram L, Johannessen SI, Tomson T(toim.) , 1999. Epilepsy and Mental Retardation. s. 147-163. Wrightson Biomedical Publishing A3 Book section, Chapters in research books

Status epilepticus-induced neuronal damage in the rat amygdaloid complex: distribution, time-course and mechanisms

Tuunanen J, Lukasiuk K, Halonen T, Pitkänen A. 1999. Neuroscience. 94: 473-495 A1 Journal article (refereed), original research

Amygdala damage in experimental and human temporal lobe epilepsy

Pitkänen A, Tuunanen J, Kälviäinen R, Partanen K, Salmenperä T. 1998. Epilepsy research. 32: 233-253 A2 Review article, Literature review, Systematic review

Calretinin-immunoreactive terminals make synapses on calbindin D28k-immunoreactive neurons in the lateral nucleus of the human amygdala

Sorvari H, Miettinen R, Soininen H, Paljärvi L, Karkola K, Pitkänen A. 1998. Brain research. 783: 355-358 A1 Journal article (refereed), original research

Hippocampal damage caused by seizures in temporal lobe epilepsy

Salmenperä T, Kälviäinen R, Partanen K, Pitkänen A. 1998. The Lancet

Intrinsic connections of the rat amygdaloid complex: projections originating in the central nucleus

Jolkkonen E, Pitkänen A. 1998. Journal of comparative neurology. 395: 53-72 A1 Journal article (refereed), original research

MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices

Insausti R, Juottonen K, Soininen H, Insausti AM, Partanen K, Vainio P, Laakso MP, Pitkänen A. 1998. American journal of neuroradiology. 19: 659-671 A1 Journal article (refereed), original research

Mantelitumake

Pitkänen A. 1998. Duodecim. 114: 2451-2459 A2 Review article, Literature review, Systematic review

Organization of the intrinsic connections of the monkey amygdaloid complex: projections originating in the lateral nucleus

Pitkänen A, Amaral DG. 1998. Journal of comparative neurology. 398: 431-458 A1 Journal article (refereed), original research

Prevention of epilepsy

Pitkänen A, Halonen T. 1998. Trends in pharmacological sciences. 19: 253-254 A1 Journal article (refereed), original research

Recurrent seizures may cause hippocampal damage in temporal lobe epilepsy

Kälviäinen R, Salmenperä T, Partanen K, Vainio P, Riekkinen P Sr, Pitkänen A. 1998. Neurology. 50: 1377-1382 A1 Journal article (refereed), original research

Remodeling of neuronal circuitries in human temporal lobe epilepsy: increased expression of highly polysialylated neural cell adhesion molecule in the hippocampus and the entorhinal cortex

Mikkonen M, Soininen H, Kälviäinen R, Tapiola T, Ylinen A, Vapalahti M, Paljärvi L, Pitkänen A. 1998. Annals of neurology. 44: 923-934 A1 Journal article (refereed), original research

Volumes of the entorhinal and perirhinal cortices in Alzheimer`s disease

Juottonen K, Laakso MP, Insausti R, Lehtovirta M, Pitkänen A, Partanen K, Soininen H. 1998. Neurobiology of aging. 19: 15-22 A1 Journal article (refereed), original research

Cholinergic deafferentation exacerbates seizure-induced loss of somatostatin-immunoreactive neurons in the rat hippocampus

Jolkkonen J, Kähkönen K, Pitkänen A. 1997. Neuroscience. 80: 401-411 A1 Journal article (refereed), original research

Decrease in somatostatin-immunoreactive neurons in the rat amygdaloid complex in a kindling model of temporal lobe epilepsy

Tuunanen J, Halonen T, Pitkänen A. 1997. Epilepsy research. 26: 315-327 A1 Journal article (refereed), original research

Distribution of calretinin-immunoreactivity in the rat entorhinal cortex:coexistence with GABA

Miettinen M, Pitkänen A, Miettinen R. 1997. Journal of comparative neurology. 378: 363-378 A1 Journal article (refereed), original research

Distribution of parvalbumin-, calretinin-, and calbindin-D28k-immunoreactive neurons and fibers in the human entorhinal cortex

Mikkonen M, Soininen H, Pitkänen A. 1997. Journal of comparative neurology. 388: 64-88 A1 Journal article (refereed), original research

Interamygdaloid projections of the basal and accessory basal nuclei of the rat amygdaloid complex

Savander V, Ledoux JE, Pitkänen A. 1997. Neuroscience. 76: 725-735 A1 Journal article (refereed), original research

Lateral nucleus of the rat amygdala is reciprocally connected with basal and accessory basal nuclei: a light and electron microscopic study

Savander V, Miettinen R, Ledoux JE, Pitkänen A. 1997. Neuroscience. 77: 767-781 A1 Journal article (refereed), original research

MRI volumetry and T2 relaxometry of the amygdala in newly diagnosed and chronic temporal lobe epilepsy

Kälviäinen R, Salmenperä T, Partanen K, Vainio P, Riekkinen P Sr, Pitkänen A. 1997. Epilepsy research. 28: 39-50 A1 Journal article (refereed), original research

MRI-based hippocampal volumetry and T2 relaxometry: correlation to verbal memory performance in newly diagnosed epilepsy patients with left-sided temporal lobe focus

Kälviäinen R, Partanen K, Äikiä M, Mervaala E, Vainio P, Riekkinen PJ Sr, Pitkänen A. 1997. Neurology. 48: 286-287 A1 Journal article (refereed), original research

Organization of intra-amygdaloid circuitries in the rat: an emerging framework for understanding functions of the amygdala

Pitkänen A, Savander V, Ledoux JE. 1997. Trends in neurosciences. 20: 517-523 A1 Journal article (refereed), original research

Seizure-induced damage to somatostatin-immunoreactive neurons in the rat hippocampus is regulated by fimbria-fornix transection

Jolkkonen J, Jolkkonen E, Pitkänen A. 1997. Experimental neurology. 145: 141-153 A1 Journal article (refereed), original research

Calbindin-D28K-immunoreactive cells and fibres in the human amygdaloid complex

Sorvari H, Soininen H, Pitkänen A. 1996. Neuroscience. 75: 421-443 A1 Journal article (refereed), original research

Calretinin-immunoreactive cells and fibers in the human amygdaloid complex

Sorvari H, Soininen H, Pitkänen A. 1996. Journal of comparative neurology. 369: 188-208 A1 Journal article (refereed), original research

Intrinsic connections of the rat amygdaloid complex: projections originating in the accessory basal nucleus

Savander V, Go C-G, Ledoux JE, Pitkänen A. 1996. Journal of comparative neurology. 374: 291-313 A1 Journal article (refereed), original research

Parvalbumin-immunoreactive neurons make inhibitory synapses on pyramidal cells in the human amygdala: a light and electron microscopic study

Sorvari H, Miettinen R, Soininen H, Pitkänen A. 1996. Neuroscience letters. 217: 93-96 A1 Journal article (refereed), original research

Seizure-induced damage to the hippocampus is prevented by modulation of the GABAergic system

Jolkkonen J, Halonen T, Jolkkonen E, Nissinen J, Pitkänen A. 1996. Neuroreport. 7: 2031-2035 A1 Journal article (refereed), original research

Severity of hippocampal atrophy correlates with the prolongation of MRI T2 relaxation time in temporal lobe epilepsy but not in Alzheimer's disease

Pitkänen A, Laakso M, Kälviäinen R, Partanen K, Vainio P, Lehtovirta M, Riekkinen P Sr, Soininen H. 1996. Neurology. 46: 1724-1730 A1 Journal article (refereed), original research

Status epilepticus causes selective regional damage and loss of GABAergic neurons in the rat amygdaloid complex

Tuunanen J, Halonen T, Pitkänen A. 1996. European journal of neuroscience. 8: 2711-2725 A1 Journal article (refereed), original research

Tiagabine prevents seizures, neuronal damage and memory impairment in experimental status epilepticus

Halonen T, Nissinen J, Jansen JA, Pitkänen A. 1996. European journal of pharmacology. 299: 69-81 A1 Journal article (refereed), original research

Topographic projections from the periamygdaloid cortex to select subregions of the lateral nucleus of the amygdala in the rat

Savander V, LeDoux JE, Pitkänen A. 1996. Neuroscience letters. 211: 167-170 A1 Journal article (refereed), original research

Treatment with antiepileptic drugs: Possible neuroprotective effects

Pitkänen A. 1996. NEUROLOGY. SUPPLEMENT. 47: S12-S16 A1 Journal article (refereed), original research

Vigabatrin and carbamazepine have different efficacies in the prevention of status epilepticus induced neuronal damage in the hippocampus and amygdala

Pitkänen A, Tuunanen J, Halonen T. 1996. Epilepsy research. 24: 29-45 A1 Journal article (refereed), original research

Abnormal regional benzodiazepine receptor uptake in the prefrontal cortex in patients with panic disorder

Kuikka JT, Pitkänen A, Lepola U, Partanen K, Vainio P, Bergström KA, Wieler HJ, Kaiser KP, Mittelbach L, Koponen H, Leinonen E, Riekkinen PJ. 1995. Nuclear medicine communications. 16: 273-280 A1 Journal article (refereed), original research

Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E epsilon 4 allele

Soininen H, Partanen K, Pitkänen A, Hallikainen M, Hänninen T, Helisalmi S, Mannermaa A, Ryynänen M, Koivisto K, Riekkinen P Sr. 1995. Neurology. 45: 391-392 A1 Journal article (refereed), original research

Distribution of parvalbumin-immunoreactive cells and fibers in the human amygdaloid complex

Sorvari H, Soininen H, Paljärvi L, Karkola K, Pitkänen A. 1995. Journal of comparative neurology. 360: 185-212 A1 Journal article (refereed), original research

Intrinsic connections of the rat amygdaloid complex: projections originating in the basal nucleus

Savander V, Go C-G, LeDoux JE, Pitkänen A. 1995. Journal of comparative neurology. 361: 345-368 A1 Journal article (refereed), original research

Intrinsic connections of the rat amygdaloid complex: projections originating in the lateral nucleus

Pitkänen A, Stefanacci L, Farb CR, Go GG, LeDoux JE, Amaral DG. 1995. Journal of comparative neurology. 356: 288-310 A1 Journal article (refereed), original research

Subiculum, presubiculum and parasubiculum have different sensitivities to seizure-induced neuronal damage in the rat

Pitkänen A, Tuunanen J, Halonen T. 1995. Neuroscience letters. 192: 65-68 A1 Journal article (refereed), original research

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Brain abscess – A rare confounding factor for diagnosis of post-traumatic epilepsy after lateral fluid-percussion injury

Circulating microRNAs and isomiRs as biomarkers for the initial insult and epileptogenesis in four experimental epilepsy models: The EPITARGET study

Plasma microRNAs as prognostic biomarkers for development of severe epilepsy after experimental traumatic brain injury —EpiBioS4Rx Project 1 study

Plasma neurofilament heavy chain is a prognostic biomarker for the development of severe epilepsy after experimental traumatic brain injury

Discovery and Validation of Circulating microRNAs as Biomarkers for Epileptogenesis after Experimental Traumatic Brain Injury–The EPITARGET Cohort

Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1

Gene Expression Profile as a Predictor of Seizure Liability

Highlights From the Annual Meeting of the American Epilepsy Society 2022

Image data harmonization tools for the analysis of post-traumatic epilepsy development in preclinical multisite MRI studies

Proteomics of Deep Cervical Lymph Nodes After Experimental Traumatic Brain Injury

Sleep Disturbance and Severe Hydrocephalus in a Normally Behaving Wistar Rat With Traumatic Brain Injury

Successful harmonization in EpiBioS4Rx biomarker study on post-traumatic epilepsy paves the way towards powered preclinical multicenter studies

Treatment of Status Epilepticus after Traumatic Brain Injury Using an Antiseizure Drug Combined with a Tissue Recovery Enhancer Revealed by Systems Biology

Acute Hippocampal Damage as a Prognostic Biomarker for Cognitive Decline but Not for Epileptogenesis after Experimental Traumatic Brain Injury

Chronic hypometabolism in striatum and hippocampal network after traumatic brain injury and their relation with memory impairment – [18F]-FDG-PET and MRI 4 months after fluid percussion injury in rat

Convolutional Neural Networks Enable Robust Automatic Segmentation of the Rat Hippocampus in MRI After Traumatic Brain Injury

Effect of cell culture media on extracellular vesicle secretion from mesenchymal stromal cells and neurons

Hippocampal position and orientation as prognostic biomarkers for posttraumatic epileptogenesis: An experimental study in a rat lateral fluid percussion model

International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke

MRI-Guided Electrode Implantation for Chronic Intracerebral Recordings in a Rat Model of Post−Traumatic Epilepsy—Challenges and Gains

Plasma Neurofilament Light Chain (NF-L) Is a Prognostic Biomarker for Cortical Damage Evolution but Not for Cognitive Impairment or Epileptogenesis Following Experimental TBI

Seizure Susceptibility and Sleep Disturbance as Biomarkers of Epileptogenesis after Experimental TBI

Shaping the future of European epilepsy research: Final meeting report from EPICLUSTER

Transfer RNA-Derived Fragments and isomiRs Are Novel Components of Chronic TBI-Induced Neuropathology

Ultrasonic vocalizations – Novel seizure-related manifestation in rats

Acute thalamic damage as a prognostic biomarker for post-traumatic epileptogenesis

Biomarkers for posttraumatic epilepsy

Climate change and epilepsy: Insights from clinical and basic science studies

Identification of clinically relevant biomarkers of epileptogenesis - a strategic roadmap

Meeting report: EpiXchange II brings together European epilepsy research projects to discuss latest advances

Novel Approaches to Prevent Epileptogenesis After Traumatic Brain Injury

Peripheral Infection after Traumatic Brain Injury Augments Excitability in the Perilesional Cortex and Dentate Gyrus

Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury

Post-injury ventricular enlargement associates with iron in choroid plexus but not with seizure susceptibility nor lesion atrophy - 6-month MRI follow-up after experimental traumatic brain injury

Regulation of parvalbumin interactome in the perilesional cortex after experimental traumatic brain injury

Reorganization of Thalamic Inputs to Lesioned Cortex Following Experimental Traumatic Brain Injury

Targeting Oxidative Stress with Antioxidant Duotherapy after Experimental Traumatic Brain Injury

Voiko epilepsian puhkeamisen ja etenemisen estää lääkehoidolla?

A Computational Diffusion MRI Framework for Biomarker Discovery in a Rodent Model of Post-Traumatic Epileptogenesis

Biomarkers For Epileptogenesis And Its Treatment

Chronic Regulation of miR-124-3p in the Perilesional Cortex After Experimental and Human TBI

Droplet digital polymerase chain reaction-based quantification of circulating microRNAs using small RNA concentration normalization

Early increase in cortical T2 relaxation is a prognostic biomarker for the evolution of severe cortical damage, but not for epileptogenesis, after experimental traumatic brain injury

Elevated acute plasma miR-124-3p level relates to evolution of larger cortical lesion area after traumatic brain injury

Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation

Kainate receptors regulate development of glutamatergic synaptic circuitry in the rodent amygdala

LifeTime and improving European healthcare through cell-based interceptive medicine

Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury

Plau/Plaur double-deficiency did not worsen lesion severity or vascular integrity after traumatic brain injury

Postinjury weight rather than cognitive or behavioral impairment predicts development of posttraumatic epilepsy after lateral fluid-percussion injury in rats

Acute downregulation of novel hypothalamic protein sushi repeat-containing protein X-Linked 2 (SRPX2) after experimental traumatic brain injury

Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats

Advancing research toward faster diagnosis, better treatment, and end of stigma in epilepsy

Common data elements (CDEs) for preclinical epilepsy research: Introduction to CDEs and description of core CDEs. A TASK3 report of the ILAE/AES joint translational task force

Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility

Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury

Epilepsy biomarkers - Toward etiology and pathology specificity

Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies

Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2)

Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis

Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis

Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis

In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury - Lessons Learned

Lateral fluid-percussion injury leads to pituitary atrophy in rats

MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex - A 6-Months Multimodal Imaging Follow-Up Study

Preclinical common data elements (CDEs) for epilepsy: A joint ILAE/AES and NINDS translational initiative

Preface - Practical and theoretical considerations for performing a multi-center preclinical biomarker discovery study of post-traumatic epileptogenesis: lessons learned from the EpiBioS4Rx consortium

Visualization of thalamic calcium influx with quantitative susceptibility mapping as a potential imaging biomarker for repeated mild traumatic brain injury

Web Application for Quantification of Traumatic Brain Injury-Induced Cortical Lesions in Adult Mice

A web-based application for generating 2D-unfolded cortical maps to analyze the location and extent of cortical lesions following traumatic brain injury in adult rats

Algorithm for automatic detection of spontaneous seizures in rats with post-traumatic epilepsy

Analytic Tools for Post-traumatic Epileptogenesis Biomarker Search in Multimodal Dataset of an Animal Model and Human Patients

Big data sharing and analysis to advance research in post-traumatic epilepsy

Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury

Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study