Asla Pitkänen

Das Gupta, Shalini; Ciszek, Robert; Heiskanen, Mette; Lapinlampi, Niina; Kukkonen, Janne; Leinonen, Ville; Puhakka, Noora; Pitkänen, Asla. 2021. Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury International journal of molecular sciences 22 4: 1563. 2021

Pitkänen, Asla. 2021. Voiko epilepsian puhkeamisen ja etenemisen estää lääkehoidolla? Duodecim 137 16: 1631 - 1637. 2021

Dulla, Chris G.; Pitkänen, Asla. 2021. Novel Approaches to Prevent Epileptogenesis After Traumatic Brain Injury Neurotherapeutics 18 3: 1582-1601. 2021

Yasmin, Amna; Pitkänen, Asla; Andrade, Pedro; Paananen, Tomi; Gröhn, Olli; Immonen, Riikka. 2021. Post-injury ventricular enlargement associates with iron in choroid plexus but not with seizure susceptibility nor lesion atrophy - 6-month MRI follow-up after experimental traumatic brain injury Brain structure and function 2022; 227 1: 145-158. 2021

Wang, Ying; Andrade, Pedro; Pitkänen Asta. 2021. Peripheral Infection after Traumatic Brain Injury Augments Excitability in the Perilesional Cortex and Dentate Gyrus Biomedicines 9 12: 1946. 2021

Simonato, Michele; Agoston, Denes V; Brooks-Kayal, Amy; Dulla, Chris; Fureman, Brandy; Henshall, David C; Pitkänen, Asla; Theodore, William H; Twyman, Roy E; Kobeissy, Firas H; Wang, Kevin K; Whittemore, Vicky; Wilcox, Karen S. 2021. Identification of clinically relevant biomarkers of epileptogenesis - a strategic roadmap Nature reviews neurology 17 4: 231-242. 2021

Pitkänen, Asla; Paananen, Tomi; Kyyriäinen, Jenni; Das Gupta, Shalini; Heiskanen, Mette; Vuokila, Niina; Bañuelos-Cabrera, Ivette; Lapinlampi, Niina; Kajevu, Natallie; Andrade, Pedro; Ciszek, Robert; Lara-Valderrábano, Leonardo; Ekolle Ndode-Ekane, Xavier; Puhakka, Noora. 2021. Biomarkers for posttraumatic epilepsy Epilepsy and behavior 121 Part B: 107080. 2021

Ndode-Ekane, Xavier Ekolle; Puigferrat Pérez, Maria del Mar; Di Sapia, Rossella; Lapinlampi, Niina; Pitkänen, Asla. 2021. Reorganization of Thalamic Inputs to Lesioned Cortex Following Experimental Traumatic Brain Injury International journal of molecular sciences 22 12: 6329. 2021

Manninen, Eppu; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkänen, Asla. 2021. Acute thalamic damage as a prognostic biomarker for post-traumatic epileptogenesis Epilepsia 62 8: 1852-1864. 2021

Kyyriäinen, Jenni; Kajevu, Natallie; Bañuelos, Ivette; Lara, Leonardo; Lipponen, Anssi; Balosso, Silvia; Hämäläinen, Elina; Das Gupta, Shalini; Puhakka, Noora; Natunen, Teemu; Ravizza, Teresa; Vezzani, Annamaria; Hiltunen, Mikko; Pitkänen, Asla. 2021. Targeting Oxidative Stress with Antioxidant Duotherapy after Experimental Traumatic Brain Injury International journal of molecular sciences 22 19: 10555. 2021

Hiltunen, Johanna; Ndode-Ekane, Xavier Ekolle; Lipponen, Anssi; Drexel, Meinrad; Sperk, Günther; Puhakka, Noora; Pitkänen, Asla. 2021. Regulation of parvalbumin interactome in the perilesional cortex after experimental traumatic brain injury Neuroscience 475: 52-72. 2021

Henshall, David C.; Guerrini, Renzo; Jozwiak, Sergiusz; Kokaia, Merab; Pitkanen, Asla; Sisodiya, Sanjay; Simonato, Michele; Cross, J. Helen; Ryvlin, Philippe; Brodie, Martin J.; Trinka, Eugen; Sofia, Francesca. 2021. Meeting report: EpiXchange II brings together European epilepsy research projects to discuss latest advances Epilepsy research 178: 106811. 2021

Gulcebi, Medine I; Bartolini, Emanuele; Lee, Omay; Lisgaras, Christos Panagiotis; Onat, Filiz; Mifsud, Janet; Striano, Pasquale; Vezzani, Annamaria; Hildebrand, Michael S; Jimenez-Jimenez, Diego; Junck, Larry; Lewis-Smith, David; Scheffer, Ingrid E; Thijs, Roland D; Zuberi, Sameer M; Blenkinsop, Stephen; Fowler, Hayley J; Foley, Aideen; Sisodiya, Sanjay M; Balestrini, Simona et al. [incl. Pitkänen. 2021. Climate change and epilepsy: Insights from clinical and basic science studies Epilepsy and behavior 116: 107791. 2021

Rajewsky, Nikolaus; Almouzni, Geneviève; Gorski, Stanislaw A; Aerts, Stein; Amit, Ido; Bertero, Michela G; Bock, Christoph; Bredenoord, Annelien L; Cavalli, Giacomo; Chiocca, Susanna; Clevers, Hans; Strooper, Bart De; Eggert, Angelika; Ellenberg, Jan; Fernández, Xosé M; Figlerowicz, Marek; Gasser, Susan M; Hubner, Norbert; Kjems, Jørgen; Knoblich, Jürgen A et al. [incl. Pitkänen, Asla; Leinonen, V. 2020. LifeTime and improving European healthcare through cell-based interceptive medicine Nature 587: 377-386. 2020

Vuokila, Niina; Gupta, Shalini Das; Huusko, Riina; Tohka, Jussi; Puhakka, Noora; Pitkänen, Asla. 2020. Elevated acute plasma miR-124-3p level relates to evolution of larger cortical lesion area after traumatic brain injury Neuroscience 433: 21-35. 2020

Vuokila, Niina; Aronica, Eleonora; Korotkov, Anatoly; van Vliet, Erwin Alexander; Nuzhat, Salma; Puhakka, Noora; Pitkänen, Asla. 2020. Chronic Regulation of miR-124-3p in the Perilesional Cortex After Experimental and Human TBI International journal of molecular sciences 21 7: 2418. 2020

van Vliet, Erwin A; Ndode-Ekane, Xavier Ekolle; Lehto, Lauri J; Gorter, Jan A; Andrade, Pedro; Aronica, Eleonora; Gröhn, Olli; Pitkänen, Asla. 2020. Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury Neurobiology of disease 145: 1-20. 2020

Ryazantseva, Maria; Englund, Jonas; Shintyapina, Alexandra; Huupponen, Johanna; Shteinikov, Vasilii; Pitkänen, Asla; Partanen, Juha; Lauri, Sari. 2020. Kainate receptors regulate development of glutamatergic synaptic circuitry in the rodent amygdala eLife 9: e52798. 2020

Kyyriäinen, Jenni; Tapiala, Jesse; Lipponen, Anssi; Ekolle Ndode-Ekane, Xavier; Pitkänen, Asla. 2020. Plau/Plaur double-deficiency did not worsen lesion severity or vascular integrity after traumatic brain injury Neuroscience letters 729: 134935. 2020

Manninen, Eppu Matias; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra Lopez, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkanen, Asla. 2020. Early increase in cortical T2 relaxation is a prognostic biomarker for the evolution of severe cortical damage, but not for epileptogenesis, after experimental traumatic brain injury Journal of neurotrauma 37 23: 2580-2594. 2020

Lapinlampi, N; Andrade, P; Paananen, T; Hämäläinen, E; Ekolle Ndode-Ekane, X; Puhakka, N; Pitkänen, A. 2020. Postinjury weight rather than cognitive or behavioral impairment predicts development of posttraumatic epilepsy after lateral fluid-percussion injury in rats Epilepsia 61 9: 2035-2052. 2020

Korotkov, Anatoly; Puhakka, Noora; Gupta, Shalini Das; Vuokila, Niina; Broekaart, Diede W M; Anink, Jasper J; Heiskanen, Mette; Karttunen, Jenni; van Scheppingen, Jackelien; Huitinga, Inge; Mills, James D; van Vliet, Erwin A; Pitkänen, Asla; Aronica, Eleonora. 2020. Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation Brain pathology 30 5: 897-912. 2020

Engel, Jerome Jr; Pitkänen, Asla. 2020. Biomarkers For Epileptogenesis And Its Treatment Neuropharmacology 167: 107735. 2020

Das Gupta, Shalini; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Pitkänen, Asla. 2020. Droplet digital polymerase chain reaction-based quantification of circulating microRNAs using small RNA concentration normalization Scientific reports 10: 9012. 2020

A Computational Diffusion MRI Framework for Biomarker Discovery in a Rodent Model of Post-Traumatic Epileptogenesis. Cabeen, Ryan P; Immonen, Riikka; Harris, Neil G; Gröhn, Olli; Smith, Gregory; Manninen, Eppu; Garner, Rachael; Duncan, Dominique; Pitkänen, Asla; Toga, Arthur W / 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI). 2020. 2020

Kyyriäinen, J; Bolkvadze, T; Koivisto, H; Lipponen, A; Pérez, LO; Ekolle Ndode-Ekane, X; Tanila, H; Pitkänen, A. 2019. Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility Epilepsy research 151: 67-74. 2019

Yasmin, Amna; Pitkänen, Asla; Jokivarsi, Kimmo; Poutiainen, Pekka; Gröhn, Olli; Immonen, Riikka. 2019. MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex - A 6-Months Multimodal Imaging Follow-Up Study Frontiers in neuroscience 13: 863. 2019

Schweser, F; Kyyriäinen, J; Preda, M; Pitkänen, A; Toffolo, K; Poulsen, A; Donahue, K; Levy, B; Poulsen, D. 2019. Visualization of thalamic calcium influx with quantitative susceptibility mapping as a potential imaging biomarker for repeated mild traumatic brain injury Neuroimage 200: 250-258. 2019

Scharfman, Helen E; Galanopoulou, Aristea S; French, Jacqueline A; Pitkänen, Asla; Whittemore, Vicky; Harte-Hargrove, Lauren C. 2019. Preclinical common data elements (CDEs) for epilepsy: A joint ILAE/AES and NINDS translational initiative Epilepsia open 3: 9-12. 2019

Santana-Gomez, C; Andrade, P; Hudson, MR; Paananen, T; Ciszek, R; Smith, G; Ali, I; Rundle, BK; Ndode-Ekane, XE; Casillas-Espinosa, PM; Immonen, R; Puhakka, N; Jones, N; Brady, RD; Perucca, P; Shultz, SR; Pitkänen, A; O'Brien, TJ; Staba, R. 2019. Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis Epilepsy research 156: 106110. 2019

Pitkänen, Asla; O'Brien, Terence J; Staba, Richard. 2019. Preface - Practical and theoretical considerations for performing a multi-center preclinical biomarker discovery study of post-traumatic epileptogenesis: lessons learned from the EpiBioS4Rx consortium Epilepsy research 156: 1-4. 2019

Pitkänen, A; Henshall, DC; Cross, JH; Guerrini, R; Jozwiak, S; Kokaia, M; Simonato, M; Sisodiya, S; Mifsud, J. 2019. Advancing research toward faster diagnosis, better treatment, and end of stigma in epilepsy Epilepsia 60 7: 1281-1292. 2019

Ndode-Ekane, XE; Santana-Gomez, C; Casillas-Espinosa, PM; Ali, I; Brady, RD; Smith, G; Andrade, P; Immonen, R; Puhakka, N; Hudson, MR; Braine, EL; Shultz, SR; Staba, RJ; O'Brien, TJ; Pitkänen, A. 2019. Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis Epilepsy research 151: 7-16. 2019

Lipponen, A; Natunen, T; Hujo, M; Ciszek, R; Hämäläinen, E; Tohka, J; Hiltunen, M; Paananen, J; Poulsen, D; Kansanen, E; Ekolle Ndode-Ekane, X; Levonen, AL; Pitkänen, A. 2019. In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury - Lessons Learned International journal of molecular sciences 20 21: 5395. 2019

Pitkänen, Asla; Ekolle, Ndode-Ekane Xavier; Lapinlampi, Niina; Puhakka, Noora. 2019. Epilepsy biomarkers - Toward etiology and pathology specificity Neurobiology of disease 123: 42-58. 2019

Karttunen, J; Heiskanen, M; Lipponen, A; Poulsen, D; Pitkänen, A. 2019. Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies International journal of molecular sciences 20 6: 1259. 2019

Harte-Hargrove, Lauren C; Galanopoulou, Aristea S; French, Jacqueline A; Pitkänen, Asla; Whittemore, Vicky; Scharfman, Helen E. 2019. Common data elements (CDEs) for preclinical epilepsy research: Introduction to CDEs and description of core CDEs. A TASK3 report of the ILAE/AES joint translational task force Epilepsia open 3 S1: 13-23. 2019

Das Gupta, S; Lipponen, A; Paldanius, KMA; Puhakka, N; Pitkänen, A. 2019. Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury Scientific reports 9: 20208. 2019

Andrade, Pedro; Banuelos-Cabrera, Ivette; Lapinlampi, Niina; Paananen, Tomi; Ciszek, Robert; Ndode-Ekane, Xavier Ekolle; Pitkanen, Asla. 2019. Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats Journal of neurotrauma 36 11: 1890-1907. 2019

Ciszek, R; Andrade, P; Tapiala, J; Pitkänen, A; Ndode-Ekane, XE. 2019. Web Application for Quantification of Traumatic Brain Injury-Induced Cortical Lesions in Adult Mice Neuroinformatics 2020; 18: 307-317. 2019

Casillas-Espinosa, PM; Andrade, P; Santana-Gomez, C; Paananen, T; Smith, G; Ali, I; Ciszek, R; Ndode-Ekane, XE; Brady, RD; Tohka, J; Hudson, MR; Perucca, P; Braine, EL; Immonen, R; Puhakka, N; Shultz, SR; Jones, NC; Staba, RJ; Pitkänen, A; O'Brien, TJ. 2019. Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis Epilepsy research 156: 106131. 2019

Anwer, Mehwish; Lara-Valderrabano, Leonardo; Karttunen, Jenni; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Pitkänen, Asla. 2019. Acute downregulation of novel hypothalamic protein sushi repeat-containing protein X-Linked 2 (SRPX2) after experimental traumatic brain injury Journal of neurotrauma 2020; 37 7: 924-938. 2019

Anwer, M; Immonen, R; Hayward, NMEA; Ndode-Ekane, XE; Puhakka, N; Gröhn, O; Pitkänen, A. 2019. Lateral fluid-percussion injury leads to pituitary atrophy in rats Scientific reports 9 1: 11819. 2019

Anwer, M; Bolkvadze, T; Puhakka, N; Ndode-Ekane, XE; Pitkänen, A. 2019. Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2) Neuroscience 415: 184-200. 2019

Immonen, R; Smith, G; Brady, RD; Wright, D; Johnston, L; Harris, NG; Manninen, E; Salo, R; Branch, C; Duncan, D; Cabeen, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Shultz, SR; Andrade, P; Puhakka, N; Staba, RJ; O'Brien, TJ; et al.. 2019. Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis Epilepsy research 150: 46-57. 2019

Kamnaksh, A; Puhakka, N; Ali, I; Smith, G; Aniceto, R; McCullough, J; Das Gupta, S; Ndode-Ekane, XE; Brady, R; Casillas-Espinosa, P; Hudson, M; Santana-Gomez, C; Immonen, R; Abreu, PA; Jones, N; Shultz, S; Staba, RJ; O'Brien, TJ; Agoston, D; Pitkänen, A. 2018. Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis EPILEPSY RESEARCH 2019; 149: 92-101. 2018

Vuokila, Niina; Lukasiuk, Katarzyna; Bot, Anna Maria; van Vliet, Erwin A; Aronica, Eleonora; Pitkänen, Asla; Puhakka Niina. 2018. miR-124-3p is a chronic regulator of gene expression after brain injury Cellular and molecular life sciences 75 24: 4557-4581. 2018

Tubi, MA; Lutkenhoff, E; Blanco, MB; McArthur, D; Villablanca, P; Ellingson, B; Diaz-Arrastia, R; Van Ness, P; Real, C; Shrestha, V; Engel, J; Jr; Vespa, PM; Agoston, D; Au, A; Bell, MJ; Bleck, T; Branch, C; Buitrago Blanco, M; Bullock, R; Burrows, BT; et al.; EpiBioS4Rx Study Group Investigators (incl. Pitkänen, Asla). 2018. Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study Neurobiology of disease 2019; 123: 115-121. 2018

Ndode-Ekane, Xavier Ekolle; Matthiesen, Liz; Bañuelos-Cabrera, Ivette; Palminha, Cátia Alexandra Pegas; Pitkänen, Asla. 2018. T-cell infiltration into the perilesional cortex is long-lasting and associates with poor somatomotor recovery after experimental traumatic brain injury RESTORATIVE NEUROLOGY AND NEUROSCIENCE 36 4: 485-501. 2018

Lipponen, Anssi; El-Osta, Assam; Kaspi, Antony; Ziemann, Mark; Khurana, Ishant; Harikrishnan, K N; Navarro-Ferrandis, Vicente; Puhakka, Noora; Paananen, Jussi; Pitkänen, Asla. 2018. Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury. Acta neuropathologica communications 6: 17. 2018

Karttunen, Jenni; Heiskanen, Mette; Navarro-Ferrandis, Vicente; Das Gupta, Shalini; Lipponen, Anssi; Puhakka, Noora; Rilla, Kirsi; Koistinen, Arto; Pitkänen, Asla. 2018. Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs Journal of Extracellular Vesicles 2019; 8 1: 1555410. 2018

Rauramaa, T; Saxlin, A; Lohvansuu, K; Alafuzoff, I; Pitkänen, A; Soininen, H. 2018. Epilepsy in neuropathologically verified Alzheimer's disease. SEIZURE 58: 9-12. 2018

Huttunen, JK; Airaksinen, AM; Barba, C; Colicchio, G; Niskanen, JP; Shatillo, A; Sierra Lopez, A; Ndode-Ekane, XE; Pitkanen, A; Gröhn, O. 2018. Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury Journal of neurotrauma 35 22: 2708-2717. 2018

Duncan, Dominique; Barisano, Giuseppe; Cabeen, Ryan; Sepehrband, Farshid; Garner, Rachael; Braimah, Adebayo; Vespa, Paul; Pitkänen, Asla; Law, Meng; Toga, Arthur W. 2018. Analytic Tools for Post-traumatic Epileptogenesis Biomarker Search in Multimodal Dataset of an Animal Model and Human Patients Frontiers in Neuroscience 12: 86. 2018

Ciszek, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Smith, G; Puhakka, N; Lapinlampi, N; Andrade, P; Kamnaksh, A; Immonen, R; Paananen, T; Hudson, MR; Brady, RD; Shultz, SR; O'Brien, TJ; Staba, RJ; Tohka, J; Pitkänen, A. 2018. Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis EPILEPSY RESEARCH 2019; 150: 17-26. 2018

Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A. 2018. Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein JOURNAL OF COMPARATIVE NEUROLOGY 526 11: 1806-1819. 2018

Andrade, Pedro; Paananen, Tomi; Ciszek, Robert; Lapinlampi, Niina; Pitkänen, Asla. 2018. Algorithm for automatic detection of spontaneous seizures in rats with post-traumatic epilepsy JOURNAL OF NEUROSCIENCE METHODS 307: 37-45. 2018

Andrade, Pedro; Ciszek, Robert; Pitkänen, Asla; Ndode-Ekane, Xavier Ekolle. 2018. A web-based application for generating 2D-unfolded cortical maps to analyze the location and extent of cortical lesions following traumatic brain injury in adult rats JOURNAL OF NEUROSCIENCE METHODS 308: 330-336. 2018

Duncan, Dominique; Vespa, Paul; Pitkanen, Asla; Braimah, Adebayo; Lapinlampi, Niina; Toga, Arthur W. 2018. Big data sharing and analysis to advance research in post-traumatic epilepsy Neurobiology of disease 2019; 123: 127-136. 2018

Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatilloa O, Sallinen J, Ndode-Ekanea XE, Pitkänen A. 2017. Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy. EPILEPSY RESEARCH 136: 18-34. 2017

van Vliet Erwin A, Puhakka Noora, Mills James D, Srivastava Prashant K, Johnson Michael R, Roncon Paolo, Das Gupta Shalini, Karttunen Jenni, Simonato Michele, Lukasiuk Katarzyna, Gorter Jan A, Aronica Eleonora, Pitkänen Asla. 2017. Standardization procedure for plasma biomarker analysis in rat models of epileptogenesis: Focus on circulating microRNAs. EPILEPSIA (NY) 58 12: 2013-2024. 2017

Tanila H, Pitkänen A. 2017. Epilepsy in Models of Alzheimer's Disease. In: Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL (ed.) Models of Seizures and Epilepsy (Second Edition). Elsevier. s. 1021-1030. 2017

Srivastava, Prashant K; Roncon, Paolo; Lukasiuk, Katarzyna; Gorter, Jan A; Aronica, Eleonora; Pitkänen, Asla; Petretto, Enrico; Johnson, Michael R; Simonato, Michele. 2017. Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy. eNeuro 4 6: 1-22. 2017

Puhakka Noora, Bot Anna Maria, Vuokila Niina, Debski Konrad Jozef, Lukasiuk Katarzyna, Pitkänen Asla. 2017. Chronically dysregulated NOTCH1 interactome in the dentate gyrus after traumatic brain injury. PLOS ONE 12 3: e0172521. 2017

Pitkänen Asla, Kyyriäinen Jenni, Andrade Pedro, Pasanen Lotta, Ndode-Ekane Xavier Ekolle. 2017. Epilepsy After Traumatic Brain Injury. In: Pitkänen Asla, Buckmaster Paul S, Galanopoulou Aristea S, Moshé Solomon L (ed.) Models of Seizures and Epilepsy (Second Edition). Elsevier. s. 661-681. 2017

Pitkänen A, Galanopoulou AS, Moshé SL, Buckmaster PS. 2017. What Can We Model?. In: Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL (ed.) Models of Seizures and Epilepsy (Second Edition). Elsevier. s. 1-3. 2017

Models of Seizures and Epilepsy (Second Edition). Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL. 2017 2017

Ndode-Ekane Xavier Ekolle, Kharatishvili Irina, Pitkänen Asla. 2017. Unfolded Maps for Quantitative Analysis of Cortical Lesion Location and Extent after Traumatic Brain Injury. JOURNAL OF NEUROTRAUMA (NEW YORK NY) 34 2: 459-474. 2017

Missault S, Peeters L, Amhaoul H, Thomae D, Van Eetveldt A, Favier B, Thakur A, Van Soom J, Pitkänen A, Augustyns K, Joossens J, Staelens S, Dedeurwaerdere S. 2017. Decreased levels of active uPA and KLK8 assessed by [111In]MICA-401 binding correlate with the seizure burden in an animal model of temporal lobe epilepsy. EPILEPSIA (NY) 58 9: 1615-1625. 2017

Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks-Kayal AR, Engel J Jr, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D et al.. 2017. Commonalities in epileptogenic processes from different acute brain insults: Do they translate?. EPILEPSIA (NY) 2018; 59 1: 37-66. 2017

Harte-Hargrove LC, French JA, Pitkänen A, Galanopoulou AS, Whittemore V, Scharfman HE. 2017. Common data elements for preclinical epilepsy research: Standards for data collection and reporting. A TASK3 report of the AES/ILAE Translational Task Force of the ILAE. EPILEPSIA (NY) 58 Suppl 4: 78-86. 2017

Galanopoulou AS, Pitkänen A, Buckmaster PS, Moshé SL. 2017. What Do Models Model? What Needs to Be Modeled?. In: Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL (ed.) Models of Seizures and Epilepsy (Second Edition). Elsevier. s. 1107-1119. 2017

Dingledine Raymond, Coulter Douglas A, Fritsch Brita, Gorter Jan A, Lelutiu Nadia, McNamara James, Nadler J Victor, Pitkänen Asla, Rogawski Michael A, Skene Pate, Sloviter Robert S, Wang Yu, Wadman Wytse J, Wasterlain Claude, Roopra Avtar. 2017. Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models. Scientific Data 4 -: 1-10. 2017

Andrade Pedro, Nissinen Jari, Pitkanen Asla. 2017. Generalized Seizures after Experimental Traumatic Brain Injury Occur at the Transition from Slow-Wave to Rapid-Eye-Movement Sleep. JOURNAL OF NEUROTRAUMA (NEW YORK NY) 34 7: 1482-1487. 2017

Pirttimäki T, Salo RA, Shatillo A, Kettunen MI, Paasonen J, Sierra A, Jokivarsi K, Leinonen V, Andrade P, Quittek S, Pitkänen A, Gröhn O. 2016. Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents. JOURNAL OF NEUROSCIENCE METHODS 274: 154-163. 2016

Ziyatdinova Sofya, Rönnbäck Annica, Gurevicius Kestutis, Miszczuk Diana, Graff Caroline, Winblad Bengt, Pitkänen Asla, Tanila Heikki. 2016. Increased Epileptiform EEG Activity and Decreased Seizure Threshold in Arctic APP Transgenic Mouse Model of Alzheimer's Disease. CURRENT ALZHEIMER RESEARCH 13 7: 817-830. 2016

van Vliet EA, Dedeurwaerdere S, Cole AJ, Friedman A, Koepp MJ, Potschka H, Immonen R, Pitkänen A, Federico P. 2016. WONOEP appraisal: Imaging biomarkers in epilepsy. EPILEPSIA (NY) 58 3: 315-330. 2016

Pitkänen A, Löscher W, Vezzani A, Becker AJ, Simonato M, Lukasiuk K, Gröhn O, Bankstahl JP, Friedman A, Aronica E, Gorter JA, Ravizza T, Sisodiya SM, Kokaia M, Beck H. 2016. Advances in the development of biomarkers for epilepsy. LANCET NEUROLOGY 15 8: 843-856. 2016

Lapinlampi N, Melin E, Aronica E, Bankstahl JP, Becker A, Bernard C, Gorter JA, Gröhn O, Lipsanen A, Lukasiuk K, Löscher W, Paananen J, Ravizza T, Roncon P, Simonato M, Vezzani A, Kokaia M, Pitkänen A. 2016. Common data elements and data management: Remedy to cure underpowered preclinical studies. EPILEPSY RESEARCH 129 January 2017: 87-90. 2016

López-Picón F, Snellman A, Shatillo O, Lehtiniemi P, Grönroos TJ, Marjamäki P, Trigg W, Jones PA, Solin O, Pitkänen A, Haaparanta-Solin M. 2016. Ex Vivo Tracing of NMDA and GABA-A Receptors in Rat Brain After Traumatic Brain Injury Using 18F-GE-179 and 18F-GE-194 Autoradiography. JOURNAL OF NUCLEAR MEDICINE 57 9: 1442-1447. 2016

Bolkvadze T, Puhakka N, Pitkänen A. 2016. Epileptogenesis after traumatic brain injury in Plaur-deficient mice. EPILEPSY & BEHAVIOR 60 July 2016: 187-196. 2016

Kyyriäinen Jenni, Ndode-Ekane Xavier Ekkolle, Pitkänen Asla. 2016. Dynamics of PDGFRß Expression in Different Cell Types After Brain Injury. GLIA 2017; 65 2 (February 2017): 322-341. 2016

Debski KJ, Pitkanen A, Puhakka N, Bot AM, Khurana I, Harikrishnan KN, Ziemann M, Kaspi A, El-Osta A, Lukasiuk K, Kobow K. 2016. Etiology matters - Genomic DNA methylation patterns in three rat models of acquired epilepsy. Scientific Reports 6: 25668. 2016

Lipponen Anssi, Paananen Jussi, Puhakka Noora, Pitkänen Asla. 2016. Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44, and S100a4 as Treatment Targets. Scientific Reports 6: 31570. 2016

Pitkänen Asla, Lukasiuk Katarzyna, Dudek F Edward, Staley Kevin J. 2015. Epileptogenesis. Cold Spring Harbor Perspectives in Medicine [epub ahead of print Sep 18, 2015]: a022822. 2015

Ziyatdinova Sofya, Viswanathan Jayashree, Hiltunen Mikko, Tanila Heikki, Pitkänen Asla. 2015. Reduction of epileptiform activity by valproic acid in a mouse model of Alzheimer's disease is not long-lasting after treatment discontinuation. EPILEPSY RESEARCH 112: 43-55. 2015

Sierra A, Gröhn O, Pitkänen A. 2015. Imaging microstructural damage and plasticity in the hippocampus during epileptogenesis. NEUROSCIENCE 309: 162-172. 2015

Rantala J, Kemppainen S, Ndode-Ekane XE, Lahtinen V, Bolkvadze Tamuna, Gurevicius K, Tanila H, Pitkänen A. 2015. Urokinase-type plasminogen activator deficiency has little effect on seizure susceptibility and acquired epilepsy phenotype but reduces spontaneous exploration in mice. EPILEPSY & BEHAVIOR 42: 117-128. 2015

Pitkänen Asla, Roivainen Reina, Luasiuk Katarzyna. 2015. Development of epilepsy after ischaemic stroke. LANCET NEUROLOGY 2016; 15 2: 185-197. 2015

Miszczuk Diana, Debski Konrad J, Tanila Heikki, Lukasiuk Katarzyna, Pitkänen Asla. 2015. Traumatic Brain Injury Increases the Expression of Nos1, Aß Clearance, and Epileptogenesis in APP/PS1 Mouse Model of Alzheimer's Disease. MOLECULAR NEUROBIOLOGY 2016; 53 10: 7010-7027. 2015

Lidster K, Jefferys JG, Blümcke I, Crunelli V, Flecknell P, Frenguelli BG, Gray WP, Kaminski R, Pitkänen A, Ragan I, Shah M, Simonato M, Trevelyan A, Volk H, Walker M, Yates N, Prescott MJ. 2015. Opportunities for improving animal welfare in rodent models of epilepsy and seizures. JOURNAL OF NEUROSCIENCE METHODS 2016; 260: 2-25. 2015

Laitinen Teemu, Sierra Alejandra, Bolkvadze Tamuna, Pitkänen Asla, Gröhn Olli. 2015. Diffusion tensor imaging detects chronic microstructural changes in white and gray matter after traumatic brain injury in rat. Frontiers in Neuroscience 9 Article 128: 12 p. 2015

Kyyriäinen J., Ndode-Ekane X. E., Pitkänen A.. 2015. Expression of PDGFR-beta positive NG2 cells in the hippocampus after status epilepticus.Wiley. E142-E143. 2015

Engel Jerome Jr, Pitkänen Asla. 2015. Epilepsy biomarkers. In: Shorvon Simon D, Perucca Emilio, Engel Jerome Jr. (Eds.) (ed.) Treatment of Epilepsy (4th Edition). WILEY-BLACKWELL. s. 103-109. 2015

Bolkvadze Tamuna, Rantala Jukka, Puhakka Noora, Andrade Petro, Pitkänen Asla. 2015. Epileptogenesis after traumatic brain injury in Plau-deficient mice. EPILEPSY & BEHAVIOR 51: 19-27. 2015

Baulac Michel, de Boer Hanneke, Elger Christian, Glynn Mike, Kälviäinen Reetta, Little Ann, Mifsud Janet, Perucca Emilio, Pitkänen Asla, Ryvlin Philippe. 2015. Epilepsy priorities in Europe: A report of the ILAE-IBE Epilepsy Advocacy Europe Task Force. EPILEPSIA (NY) [epub ahead of print 28 SEP 2015]: -. 2015

Pitkänen A, Ndode-Ekane XE, Lukasiuk K, Wilczynski GM, Dityatev A, Walker MC, Chabrol E, Dedeurwaerdere S, Vazquez N, Powell EM. 2014. Neural ECM and epilepsy. PROGRESS IN BRAIN RESEARCH (AMSTERDAM) 214: 229-62. 2014

Simonato Michele, Brooks-Kayal Amy R, Engel Jr Jerome, Galanopoulou Aristea S, Jensen Frances E, Moshé Solomon L, O'Brien Terence J, Pitkanen Asla, Wilcox Karen S, French Jacqueline A. 2014. The challenge and promise of anti-epileptic therapy development in animal models. LANCET NEUROLOGY 13 9: 949-60. 2014

Rosenow F, Alonso-Vanegas MA, Baumgartner C, Blümcke I, Carreño M, Gizewski ER, Hamer HM, Knake S, Kahane P, Lüders HO, Mathern GW, Menzler K, Miller J, Otsuki T, Ozkara C, Pitkänen A, Roper SN, Sakamoto AC, Sure U, Walker MC, Steinhoff BJ; Surgical Task Force, Commission on Therapeutic Strategies of the ILAE. 2014. In response to commentary on cavernoma-related epilepsy: review and recommendations for management-report of the surgical task force of the ILAE commission on therapeutic strategies. EPILEPSIA (NY) 55 3: 466-467. 2014

Powell Kim L, Lukasiuk Katarzyna, O'Brien Terence J, Pitkänen Asla. 2014. Are Alterations in Transmitter Receptor and Ion Channel Expression Responsible for Epilepsies?: Helen E. Scharfman, Paul S. Buckmaster, Issues in Clinical Epileptology: A View from the Bench. Advances in Experimental Medicine and Biology 813. 211-29. 2014

Pitkänen Asla, Kemppainen Samuli, Ndode-Ekane Xavier Ekolle, Huusko Noora, Huttunen Joanna K, Gröhn Olli, Immonen Riikka, Sierra Alejandra, Bolkvadze Tamuna. 2014. Posttraumatic epilepsy - Disease or comorbidity?. EPILEPSY & BEHAVIOR 2014 Feb 11. [Epub ahead of print]: --. 2014

Pitkänen Asla, Immonen Riitta. 2014. Epilepsy related to traumatic brain injury. NEUROTHERAPEUTICS 11 2: 286-296. 2014

Brain Extracellular Matrix in Health and Disease. Dityatev A, Wehrle-Haller B, Pitkänen A. 2014 2014

Pitkänen A, Immonen R, Ndode-Ekane X, Gröhn O, Stöhr T, Nissinen J. 2014. Effect of lacosamide on structural damage and functional recovery after traumatic brain injury in rats. EPILEPSY RESEARCH 2014 May;108(4): 653-65. 2014

Pitkänen A, Huusko N, Ndode-Ekane XE, Kyyriäinen J, Lipponen A, Lipsanen A, Sierra A, Bolkvadze T. 2014. Gender issues in antiepileptogenic treatments. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 2014 Jun 6 ePub ahead of print: pii: S0969-9961(14)00163-6. 2014

Pitkänen A, Engel J Jr. 2014. Past and Present Definitions of Epileptogenesis and Its Biomarkers. NEUROTHERAPEUTICS 2014 Apr;11(2): 231-41. 2014

Mishra Asht Mangal, Bai Xiaoxiao, Sanganahalli Basavaraju G, Waxman Stephen G, Shatillo Olena, Gröhn Olli, Hyder Fahmeed, Pitkänen Asla, Blumenfeld Hal. 2014. Decreased resting functional connectivity after traumatic brain injury in the rat. PLOS ONE [ONLINE] 2014 Apr 18;9(4): e95280. 2014

Menzler K, Hermsen A, Balkenhol K, Duddek C, Bugiel H, Bauer S, Schorge S, Reif PS, Klein KM, Haag A, Oertel WH, Hamer HM, Knake S, Trucks H, Sander T, Rosenow F; EPICURE-Consortium. 2014. A common SCN1A splice-site polymorphism modifies the effect of carbamazepine on cortical excitability--a pharmacogenetic transcranial magnetic stimulation study. EPILEPSIA (NY) 2014 Feb;55(2): 362-9. 2014

Huusko N, Pitkänen A. 2014. Parvalbumin immunoreactivity and expression of GABAA receptor subunits in the thalamus after experimental TBI. NEUROSCIENCE 2014 May 16;267: 30-45.. 2014

Drexel M, Puhakka N, Kirchmair E, Hörtnagl H, Pitkänen A, Sperk G. 2014. Expression of GABA receptor subunits in the hippocampus and thalamus after experimental traumatic brain injury. NEUROPHARMACOLOGY 2014 Sep 16: pii: S0028-3908(14)00306-2. 2014

Sierra A, Laitinen T, Gröhn O, Pitkänen A. 2013. Diffusion tensor imaging of hippocampal network plasticity. Brain structure & function 220 2: 781-801. 2013

Rosenow F, Alonso-Vanegas MA, Baumgartner C, Blümcke I, Carreño M, Gizewski ER, Hamer HM, Knake S, Kahane P, Lüders HO, Mathern GW, Menzler K, Miller J, Otsuki T, Ozkara C, Pitkänen A, Roper SN, Sakamoto AC, Sure U, Walker MC, Steinhoff BJ; Surgical Task Force, Commission on Therapeutic Strategies of the ILAE. 2013. Cavernoma-related epilepsy: Review and recommendations for management-Report of the Surgical Task Force of the ILAE Commission on Therapeutic Strategies. EPILEPSIA (NY) 2013 Dec;54(12):: 2025-35.. 2013

Niskanen JP, Airaksinen AM, Sierra A, Huttunen JK, Nissinen J, Karjalainen PA, Pitkänen A, Gröhn OH. 2013. Monitoring functional impairment and recovery after traumatic brain injury in rats by FMRI. JOURNAL OF NEUROTRAUMA (NEW YORK NY) 2013 Apr 1;30(7): 546-56. 2013

Pitkänen A, Nehlig A, Brooks-Kayal AR, Dudek FE, Friedman D, Galanopoulou AS, Jensen FE, Kaminski RM, Kapur J, Klitgaard H, Löscher W, Mody I, Schmidt D. 2013. Issues related to development of antiepileptogenic therapies. EPILEPSIA (NY) 2013 Aug;54 Suppl 4:: 35-43. 2013

Pitkänen Asla. 2013. Targets for antiepileptogenesis: Overview: Potschka H and Lerche H (eds.), Therapeutic targets and perspectives in the pharmacological treatment of epilepsy. 86-90. 2013

Immonen R, Kharatishvili I, Gröhn O, Pitkänen A. 2013. MRI biomarkers for post-traumatic epileptogenesis.. JOURNAL OF NEUROTRAUMA (NEW YORK NY) 2013 Jul 15;30(14): 1305-9. 2013

Huusko N, Römer C, Ndode-Ekane XE, Lukasiuk K, Pitkänen A. 2013. Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy. Brain structure & function 2015; 220 1: 153-191. 2013

Galanopoulou AS, Kokaia M, Loeb JA, Nehlig A, Pitkänen A, Rogawski MA, Staley KJ, Whittemore VH, Edward Dudek F. 2013. Epilepsy therapy development: Technical and methodologic issues in studies with animal models. EPILEPSIA (NY) 2013 Aug;54 Suppl 4: 13-23. 2013

Epilepsy Advocacy Europe, Sheanon E, Pitkänen A. 2013. Epilepsy on the horizon. EPILEPSIA (NY) 54: 1713-4. 2013

Engel J Jr, Pitkänen A, Loeb JA, Dudek FE, Bertram EH 3rd, Cole AJ, Moshé SL, Wiebe S, Jensen FE, Mody I, Nehlig A, Vezzani A. 2013. Epilepsy biomarkers. EPILEPSIA (NY) 2013 Aug;54 Suppl 4: 61-69. 2013

Zilberter M, Ivanov A, Ziyatdinova S, Mukhtarov M, Malkov A, Alpár A, Tortoriello G, Botting CH, Fülöp L, Osypov AA, Pitkänen A, Tanila H, Harkany T, Zilberter Y. 2012. Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease. JOURNAL OF NEUROCHEMISTRY 2012 Dec 14.[Epub ahead of print]: --. 2012

Pitkänen Asla, Bolkvadze Tamuna. 2012. Head Trauma and Epilepsy: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. 331-342. 2012

Ndode-Ekane XE, Pitkänen A. 2012. Urokinase-Type Plasminogen Activator Receptor Modulates Epileptogenesis in Mouse Model of Temporal Lobe Epilepsy. MOLECULAR NEUROBIOLOGY 2012 Dec 21. [Epub ahead of print]: --. 2012

Lukasiuk K, Pitkänen A. 2012. Molecular Basis of Acquired Epileptogenesis: Stefan H, Theodore W, Handbook of clinical neurology: Epilepsy Part I: Basic Principles and Diagnosis. Handbook of Clinical Neurology Volume 107: Epilepsy Part I. 3-12. 2012

Kubova H, Lukasiuk K, Pitkänen A. 2012. New Insight on the Mechanisms of Epileptogenesis in the Developing Brain: Akalan Nejat, Di Rocco Concezio, Pediatric Epilepsy Surgery. Advances and Technical Standards in Neurosurgery Vol. 39. --. 2012

Lehto LJ, Sierra A, Corum CA, Zhang J, Idiyatullin D, Pitkänen A, Garwood M, Gröhn O. 2012. Detection of Calcifications In Vivo and Ex Vivo after Brain Injury in Rat Using SWIFT. NEUROIMAGE 2012 Jul 16;61(4): 761-72. 2012

Kobow K, Auvin S, Jensen F, Löscher W, Mody I, Potschka H, Prince D, Sierra A, Simonato M, Pitkänen A, Nehlig A, Rho JM. 2012. Finding a better drug for epilepsy: Antiepileptogenesis targets. EPILEPSIA (NY) 2012 Nov;53(11): 1868-1876. 2012

Galanopoulou AS, Buckmaster PS, Staley KJ, Moshé SL, Perucca E, Engel J Jr, Löscher W, Noebels JL, Pitkänen A, Stables J, White HS, O'Brien TJ, Simonato M. 2012. Identification of new epilepsy treatments: issues in preclinical methodology. EPILEPSIA (NY) 2012 Mar;53(3): 571-82. 2012

Baulac M, De Boer H, Elger C, Glynn M, Kälviäinen R, Little A, Mifsud J, Perucca E, Pitkänen A. 2012. The Written Declaration on Epilepsy: An important achievement for Europe and beyond SEIZURE 21: 75-76. 2012

Airaksinen AM, Hekmatyar SK, Jerome N, Niskanen JP, Huttunen JK, Pitkänen A, Kauppinen RA, Gröhn OH. 2012. Simultaneous BOLD fMRI and local field potential measurements during kainic acid-induced seizures. EPILEPSIA (NY) 2012 Jul;53(7): 1245-53. 2012

Ziyatdinova Sofya, Gurevicius Kestutis, Kutchiashvili Nino, Bolkvadze Tamuna, Nissinen Jari, Tanila Heikki, Pitkänen Asla. 2011. Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels. EPILEPSY RESEARCH 94: 75-85. 2011

Sierra Alejandra, Laitinen Teemu, Lehtimäki Kimmo, Rieppo Lassi, Pitkänen Asla, Gröhn Olli. 2011. Diffusion tensor MRI with tract-based spatial statistics and histology reveals undiscovered lesioned areas in kainate model of epilepsy in rat. Brain Structure and Function 216: 123-135. 2011

Pitkänen Asla, Lukasiuk Katarzyna. 2011. Mechanisms of epileptogenesis and potential treatment targets. LANCET NEUROLOGY 10: 173-186. 2011

Pitkänen Asla, Bolkvadze Tamuna, Immonen Riikka. 2011. Anti-epileptogenesis in rodent post-traumatic epilepsy models NEUROSCIENCE LETTERS 497: 163-171. 2011

Pitkänen A, Lukasiuk K. 2011. Molecular biomarkers of epileptogenesis Biomarkers in Medicine 5 5: 629-33. 2011

Pavlov I,Huusko N,Drexel M,Kirchmair E,Sperk G,Pitkänen A,Walker MC. 2011. Progressive loss of phasic, but not tonic, GABAA receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats NEUROSCIENCE 194: 208-219. 2011

Hayward Nick Mark Edward Alexander, Tuunanen Pasi, Immonen Riikka, Ndode-Ekane Xavier Ekolle, Pitkänen Asla, Gröhn Olli. 2011. Magnetic resonance imaging of regional hemodynamic and cerebrovascular recovery after lateral fluid-percussion brain injury in rats. Journal of Cerebral Blood Flow & Metabolism 31: 166-177. 2011

Gröhn O, Sierra A, Immonen R, Laitinen T, Lehtimäki K, Airaksinen A, Hayward N, Nairismagi J, Lehto L, Pitkänen A. 2011. Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain EPILEPSIA (NY) 52(Suppl. 8): 57-60. 2011

Bolkvadze T, Pitkänen A. 2011. Development of Post-Traumatic Epilepsy after Controlled Cortical Impact and Lateral Fluid-Percussion-Induced Brain Injury in the Mouse. JOURNAL OF NEUROTRAUMA (NEW YORK NY) 2012:29(5) 2012 Jan 4. [Epub ahead of print]: 789-812. 2011

Pitkänen A. 2010. Therapeutic approaches to epileptogenesis - hope on the horizon EPILEPSIA. SUPPLEMENT 3: 2-17. 2010

Pitkänen A & Bolkvadze T. 2010. Epileptogenesis after traumatic brain injury. In: (ed.) , Atlas of Epilepsies. ss. 335-341. 2010

Ndode-Ekane XE, Hayward N, Gröhn O & Pitkänen A. 2010. Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy. NEUROSCIENCE 166: 312-332. 2010

Laitinen T, Sierra A, Pitkänen A & Gröhn O. 2010. Diffusion tensor MRI of axonal plasticity in the rat hippocampus. NEUROIMAGE 51: 251-530. 2010

Lahtinen L, Ndode-Ekane XE, Barinka F, Akamine Y, Esmaeili MH, Rantala J & Pitkänen A. 2010. Urokinase-type plasminogen activator regulates neurodegeneration and neurogenesis but not vascular changes in the mouse hippocampus after status epilepticus NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 37: 692-703. 2010

Kharatishvili I & Pitkänen A. 2010. Posttraumatic epilepsy. CURRENT OPINION IN NEUROLOGY (PHILADELPHIA PA) 23 2: 183-188. 2010

Kharatishvili I & Pitkänen A. 2010. Association of the severity of cortical damage with the occurrence of spontaneous seizures and hyperexcitability in an animal model of posttraumatic epilepsy. EPILEPSY RESEARCH 90: 47-59. 2010

Hayward NM, Ndode-Ekane XE, Kutchiashvili N, Gröhn O Pitkänen A.. 2010. Elevated cerebral blood flow and vascular density in the amygdala after status epilepticus in rats. NEUROSCIENCE LETTERS 484: 39-42. 2010

Hayward NM, Immonen R, Tuunanen PI, Ndode-Ekane XE, Gröhn O & Pitkänen A. 2010. Association of chronic vascular changes with functional outcome after traumatic brain injury in rats JOURNAL OF NEUROTRAUMA (NEW YORK NY) 27: 2203-2219. 2010

Airaksinen AM, Niskanen JP, Chamberlain R, Huttunen JK, Nissinen J, Garwood M, Pitkänen A & Gröhn O. 2010. Simultaneous fMRI and local field potential measurements during epileptic seizures in medetomidine-sedated rats using raser pulse sequence MAGNETIC RESONANCE IN MEDICINE 64: 1191-1199. 2010

Pitkänen A, Lukasiuk K. 2009. Seizure-induced gene expression: Schwartzkroin PA, Encyclopedia of Basic Epilepsy Research.Academic Press. 1302-1309. 2009

Pitkänen A, Lukasiuk K. 2009. Molecular and cellular basis of epileptogenesis in symptomatic epilepsy. EPILEPSY & BEHAVIOR 14: 16-25. 2009

Pitkänen A, Lukasiuk K. 2009. Epilepsy: Neuronal Death: Squire LR, Enclyclopedia of Neuroscience. Vol. 3.Academid Press. 1159-1166. 2009

Pitkänen A, Immonen RJ, Gröhn OH, Kharatishvili I. 2009. From traumatic brain injury to posttraumatic epilepsy: what animal models tell us about the process and treatment options. EPILEPSIA. SUPPLEMENT 50 2: 21-29. 2009

Marklund N, Morales D, Clausen F, Hånell A, Kiwanuka O, Pitkänen A, Gimbel DA, Philipson O, Lannfelt L, Hillered L, Strittmatter SM, McIntosh TK. 2009. Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice. NEUROSCIENCE 163: 540-551. 2009

Minkeviciene R, Rheims S, Dobszay MB, Zilberter M, Hartikainen J, Fülöp L, Penke B, Zilberter Y, Harkany T, Pitkänen A, Tanila H. 2009. Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy. JOURNAL OF NEUROSCIENCE 29 11: 3453-3462. 2009

Noé F, Frasca A, Balducci C, Carli M, Sperk G, Ferraguti F, Pitkänen A, Bland R, Fitzsimons H, During M, Vezzani A. 2009. Neuropeptide Y overexpression using recombinant adeno-associated viral vectors. NEUROTHERAPEUTICS 6: 300-306. 2009

Majak K, Dabrowski M, Pitkänen A. 2009. Epileptogenesis alters gene expression pattern in rats subjected to amygdala-dependent emotional learning. NEUROSCIENCE 159: 468-482. 2009

Lahtinen L, Huusko N, Myöhänen H, Lehtivarjo AK, Pellinen R, Turunen MP, Ylä-Herttuala S, Pirinen E, Pitkänen A. 2009. Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus. NEUROSCIENCE 163: 316-328. 2009

Kriegstein AR, Pitkänen A. 2009. Commentary: the prospect of cell-based therapy for epilepsy NEUROTHERAPEUTICS 6: 295-299. 2009

Kharatishvili I, Sierra A, Immonen RJ, Gröhn OHJ, Pitkänen A. 2009. Quantitative T2 mapping as a potential marker for the initial assessment of the severity of damage after traumatic brain injury in rat. EXPERIMENTAL NEUROLOGY 217: 154-164. 2009

Kharatishvili I, Pitkänen A. 2009. Posttraumatic models: Schwartzkroin PA, Encyclopedia of Basic Epilepsy Research. Vol. 3.Academic Preess. 1229-1238. 2009

Immonen RJ, Kharatishvili I, Niskanen J-P, Gröhn H, Pitkänen A, Gröhn OHJ. 2009. Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat - 11 months follow-up. EXPERIMENTAL NEUROLOGY 215: 29-40. 2009

Immonen RJ, Kharatishvili I, Gröhn H, Pitkänen A, Gröhn OHJ. 2009. Quantitative MRI predicts long-term structural and functional outcome after experimental traumatic brain injury NEUROIMAGE 45: 1-9. 2009

Maja K, Pitkänen A. 2009. Genes relevant to epileptogenic mechanisms. In: Avanzini G, Noebels J (ed.) , Genetics of Epilepsy and Genetic Epilepsies.John Libbey Eurotext. ss. 31-38. 2009

Immonen RJ, Kharatishvili I, Sierra A, Einula C, Pitkänen A, Gröhn OH. 2008. Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus NEUROIMAGE 40: 1718-1730. 2008

Noè F, Pool AH, Nissinen J, Gobbi M, Bland R, Rizzi M, Balducci C, Ferraguti F, Sperk G, During MJ, Pitkänen A, Vezzani A. 2008. Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy. BRAIN 131 6: 1506-1515. 2008

Nissinen J, Pitkänen A. 2007. Effect of antiepileptic drugs on spontaneous seizures in epileptic rats. EPILEPSY RESEARCH 73 2: 181-191. 2007

Sisodiya S, Cross JH, Blümcke I, Chadwick D, Craig J, Crino PB, Debenham P, Delanty N, Elmslie F, Gardiner M, Golden J, Goldstein D, Greenberg DA, Guerrini R, Hanna M, Harris J, Harrison P, Johnson MR, Kirov G, Kullman DM, Makoff A, Marini C. 2007. Genetics of epilepsy: epilepsy research foundation workshop report. EPILEPTIC DISORDERS 9 2: 194-236. 2007

Siiskonen H, Oikari S, Korhonen V-P, Pitkänen A, Voikar V, Kettunen M, Hakumäki J, Wahlfors T, Pussinen R, Penttonen M, Kiehne K, Kaasinen SK, Alhonen L, Jänne J, Herzig K-H. 2007. Diazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocamus-depend learning. MOLECULAR AND CELLULAR NEUROSCIENCE (SAN DIEGO CA) 34 2: 199-208. 2007

Pitkänen A. 2007. Neuroprotection with anti-epileptic drugs: state of the evidence: Trimble MR, Seizure Freedom: Clinical, Research and Quality of Life Perspectives.Clarius Press. 9-27. 2007

Pitkänen A, Mathiesen C, Rønn LCB, Møller A, Nissinen J. 2007. Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat EPILEPSY RESEARCH 74 1: 45-54. 2007

Noe' F, Nissinen J, Pitkänen A, Gobbi M, Sperk G, During M, Vezzani A. 2007. Gene therapy in epilepsy: The focus on NPY. PEPTIDES 28 2: 377-383. 2007

Pitkänen A, Kharatisvili I, Karhunen H, Lukasiuk K, Immonen R, Nairismägi J, Gröhn O, Nissinen J. 2007. Epileptogenesis in experimental models. EPILEPSIA. SUPPLEMENT 48 2: 13-20. 2007

Narkilahti S, Jutila L, Alafuzoff I, Karkola K, Paljärvi L, Immonen A, Vapalahti M, Mervaala E, Kälviäinen R, Pitkänen A. 2007. Increased expression of caspase 2 in experimental and human temporal lobe epilepsy NEUROMOLECULAR MEDICINE 9 2: 129-144. 2007

Kharatishvili I, Immonen R, Gröhn O, Pitkänen A. 2007. Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis. BRAIN 130 12: 3155-3168. 2007

Keck CA, Thompson HJ, Pitkänen A, LeBold DG, Morales DM, Plevy JB, Puri R, Zhao B, Dichter M, McIntosh TK. 2007. The novel antiepileptic agent RWJ-333369-A, but not its analog RWJ-333369, reduces regional cerebral edema without affecting neurobehavioral outcome or cell death following experimental traumatic brain injury. RESTORATIVE NEUROLOGY AND NEUROSCIENCE 25 2: 77-90. 2007

Karhunen H, Bezvenyuk Z, Nissinen J, Sivenius J, Jolkkonen J, Pitkänen A, Sivenius J. 2007. Epileptogenesis after cortical photothrombotic brain lesion in rats. NEUROSCIENCE 148 1: 314-324. 2007

Gröhn O, Pitkänen A. 2007. Magnetic resonance imaging in animal models of epilepsy-noninvasive detection of structural alterations. EPILEPSIA. SUPPLEMENT 48 4: 3-10. 2007

Goffin K, Nissinen J, Van Laere K, Pitkänen A. 2007. Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat. EXPERIMENTAL NEUROLOGY 205: 501-505. 2007

Majak K, Pitkänen A. 2007. Mechanisms of emotional learning in normal and epileptic brain: Natsume K, Hanazawa A, Miki T, Brain-Inspired IT III.Elsevier. International Congress Series. 22-27. 2007

Nairismägi J, Pitkänen A, Narkilahti S, Huttunen J, Kauppinen RA, Gröhn OHJ. 2006. Manganese-enhanced magnetic resonance imaging of mossy fiber plasticity in vivo. NEUROIMAGE 30 1: 130-135. 2006

Pitkänen A. 2006. New data suggest that discontinuation of status epilepticus is not necessary for antiepileptogenic effect in immature brain. EPILEPSY CURRENTS 6 5: 170-172. 2006

Pitkänen A, Mcintosh TK. 2006. Animal models of post-traumatic epilepsy. JOURNAL OF NEUROTRAUMA (NEW YORK NY) 23 2: 241-261. 2006

Pitkänen A, Gilliam F. 2006. Change over of the baton. EPILEPSY RESEARCH 70 2-3: 95. 2006

Pirttilä TJ, Pitkänen A. 2006. Cystatin C expression is increased in the hippocampus following photothrombotic stroke in rat. NEUROSCIENCE LETTERS 395 2: 108-113. 2006

Lukasiuk K, Dabrowski M, Adach A, Pitkänen A. 2006. Chapter 11 Epileptogenesis-related genes revisited. PROGRESS IN BRAIN RESEARCH (AMSTERDAM) 158: 223-241. 2006

Nairismägi J, Pitkänen A, Kettunen MI, Kauppinen RA, Kubova H. 2006. Status epilepticus in 12-day-old rats leads to temporal lobe neurodegeneration and volume reduction: A histologic and MRI study. EPILEPSIA (NY) 47 3: 479-488. 2006

Lahtinen L, Lukasiuk K, Pitkänen A. 2006. Increased expression and activity of urokinase-type plasminogen activator during epileptogenesis. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 24 7: 1935-1945. 2006

Kharatishvili I, Nissinen JP, McIntosh TK, Pitkänen A. 2006. A model of posttraumatic epilepsy induced by lateral fluid-percussion brain injury in rats. NEUROSCIENCE 140: 685-697. 2006

Kemppainen EJS, Nissinen J, Pitkänen A. 2006. Fear conditioning is impaired in systemic kainic acid and amygdala-stimulation models of epilepsy. EPILEPSIA (NY) 47 5: 820-829. 2006

Karhunen H, Nissinen J, Sivenius J, Jolkkonen J, Pitkänen A. 2006. A long-term video-EEG and behavioral follow-up after endothelin-1 induced middle cerebral artery occlusion in rats. EPILEPSY RESEARCH 72: 25-38. 2006

Salmenperä T, Könönen M, Roberts N, Vanninen R, Pitkänen A, Kälviäinen R, Könönen M. 2005. Hippocampal damage in newly diagnosed focal epilepsy: a prospective MRI study. NEUROLOGY 64: 62-68. 2005

Päivinen N, Lammi S, Pitkänen A, Nissinen J, Penttonen M, Grönfors T. 2005. Epileptic seizure detection: A nonlinear viewpooint. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE 79 2: 151-159. 2005

Pitkänen A, Kharatishvili I, Narkilahti S, Lukasiuk K, Nissinen J. 2005. Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat. EPILEPSY RESEARCH 63: 27-42. 2005

Pitkänen A, Gröhn O. 2005. Experimental febrile seizures require an undetermined factor for induction of hippocampal sclerosis in immature rat brain. EPILEPSY CURRENTS 53 3: 98-100. 2005

Pirttilä TJ, Manninen A, Jutila L, Nissinen J, Kälviäinen R, Vapalahti M, Immonen A, Paljärvi L, Karkola K, Alafuzoff I, Mervaala E, Pitkänen A. 2005. Cystatin C expression is associated with granule cell dispersion in epilepsy. ANNALS OF NEUROLOGY 58 2: 211-223. 2005

Pirttilä TJ, Lukasiuk K, Håkansson K, Grubb A, Abrahamson M, Pitkänen A. 2005. Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 20: 241-253. 2005

Morales DM, Marklund N, Lebold D, Thompson HJ, Pitkanen A, Maxwell WL, Longhi L, Laurer H, Maegele M, Neugebauer E, Graham DI, Stocchetti N, McIntosh TK. 2005. Experimental models of traumatic brain injury: Do we really need to build a better mousetrap?. NEUROSCIENCE 136 4: 971-989. 2005

Karhunen H, Jolkkonen J, Sivenius J, Pitkänen A. 2005. Epileptogenesis after experimental focal cerebral ischemia. NEUROCHEMICAL RESEARCH 30 12: 1529-1542. 2005

Goncalves Pereira PM, Insausti R, Artacho-Pérula E, Salmenperä T, Kälviäinen R, Pitkänen A. 2005. MR volumetric analysis of the piriform cortex and cortical amygdala in drug-refractory temporal lobe epilepsy. AJNR. AMERICAN JOURNAL OF NEURORADIOLOGY 26: 319-332. 2005

Narkilahti S, Pitkänen A. 2005. Caspase 6 expression in the rat hippocampus during epileptogenesis and epilepsy. NEUROSCIENCE 131 4: 887-897. 2005

Nissinen J, Large CH, Stratton SC, Pitkänen A. 2004. Effect of lamotrigine treatment on epileptogenesis: an experimental study in rat EPILEPSY RESEARCH 58 2-3: 119-132. 2004

Pitkänen A. 2004. New pharmacotherapy for epilepsy. IDRUGS: THE INVESTIGATIONAL DRUGS JOURNAL 7 5: 471-477. 2004

Pitkänen A. 2004. Denervation and reinnervation of amygdaloid neurons in drug-refratory temporal lobe epilepsy EPILEPSY CURRENTS 4 2: 78-79. 2004

Pitkänen A, Narkilahti S, Bezvenyuk Z, Haapalinna A, Nissinen J. 2004. Atipamezole, an alfa2-adrenoceptor antagonist, has disease modifying effects on epileptogenesis in rats EPILEPSY RESEARCH 61: 119-140. 2004

Pitkänen A, Kubova H. 2004. Antiepileptic drugs in neuroprotections. EXPERT OPINION ON PHARMACOTHERAPY 5 4: 777-798. 2004

Niittykoski M, Nissinen J, Penttonen M, Pitkänen A. 2004. Electrophysiologic changes in the lateral and basal amygdaloid nuclei in temporal lobe epilepsy: an in vitro study in epileptic rats. NEUROSCIENCE 124: 269-281. 2004

Nairismägi J, Gröhn OHJ, Kettunen MI, Nissinen J, Kauppinen RA, Pitkänen A. 2004. Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepy EPILEPSIA (NY) 45 9: 1024-1034. 2004

Majak K, Rönkkö S, Kemppainen S, Pitkänen A. 2004. Projections from the amygdaloid complex to the piriform cortex: A PHA-L study in the rat. JOURNAL OF COMPARATIVE NEUROLOGY 476: 414-428. 2004

Majak K, Pitkänen A. 2004. Do seizures cause irreversible cognitive damage? Evidence from animal studies. EPILEPSY & BEHAVIOR. SUPPLEMENT 5: S35-S44. 2004

Lähteinen S, Pitkänen A, Knuuttila J, Törönen P, Castrén E. 2004. Brain-derived neurotrophic factor signaling modifies hippocampal gene expression during epileptogenesis in transgenic mice. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 19 12: 3245-3254. 2004

Lukasiuk K, Pitkänen A. 2004. Large-scale analysis of gene expression in epilepsy reseach: is synthesis alreasy possible?. NEUROCHEMICAL RESEARCH 29 6: 1169-1178. 2004

Kubová H, Mares P, Suchomelová L, Brozek G, Druga R, Pitkänen A. 2004. Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 19 12: 3255-3265. 2004

Kemppainen S, Pitkänen A. 2004. Damage to the amygdalo-hippocampal projection in temporal lobe epilepsy: A tract-tracing study in chronic epileptic rats. NEUROSCIENCE 126 2: 485-501. 2004

Pitkänen A, Savander M, Nurminen N, Ylinen A. 2003. Intrinsic synaptic circuitry of the amygdala ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 985: 34-49. 2003

The Amygdala in Brain Function: Basic and Clinical Approaches. Shinnick-Gallagher P, Pitkänen A, Shekhar A, Cahill L. 2003 2003

Sutula TP, Hagen J, Pitkänen A. 2003. Do epileptic seizures damage the brain?. CURRENT OPINION IN NEUROLOGY (PHILADELPHIA PA) 16 2: 189-195. 2003

Stables JP, Bertram E, Dudek FE, Holmes G, Mathern G, Pitkanen A, White HS. 2003. Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: summary of the NIH/NINDS/AES models II workshop. EPILEPSIA (NY) 44 12: 1472-1478. 2003

Pitkänen A. 2003. Tunteiden neurobiologiaa. DUODECIM 119: 1471-1478. 2003

Pitkänen A. 2003. Clinical trials in neuroprotection. IDRUGS: THE INVESTIGATIONAL DRUGS JOURNAL 6 3: 200-202. 2003

Pitkänen A. 2003. American Epilepsy Society - 56th Annual Meeting. IDRUGS: THE INVESTIGATIONAL DRUGS JOURNAL 6 2: 102-103. 2003

Laurén HB, Pitkänen A, Nissinen J, Soini SL, Korpi ER, Holopainen IE. 2003. Selective changes in gamma-aminobutyric acid type A receptor subunits in the hippocampus in spontaneously seizing rats with chronic temporal lobe epilepsy. NEUROSCIENCE LETTERS 349: 58-62. 2003

Narkilahti S, Pirttilä TJ, Lukasiuk K, Tuunanen J, Pitkänen A. 2003. Expression and activation of caspase 3 following status epilepticus in the rat. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 18 6: 1486-1496. 2003

Narkilahti S, Nissinen J, Pitkänen A. 2003. Administration of caspase 3 inhibitor during and after status epilepticus in rat: effect on neuronal damage and epileptogenesis. NEUROPHARMACOLOGY 44: 1068-1088. 2003

Majak K, Pitkänen A. 2003. Projections from the periamygdaloid cortex to the amygdaloid complex, the hippocampal formation, and the parahippocampal region: A PHA-L study in the rat. HIPPOCAMPUS 13 8: 922-942. 2003

Majak K, Pitkänen A. 2003. Activation of the amygdalo-entorhinal pathway in fear-conditioning in rat. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 18 6: 1652-1659. 2003

Lähteinen S, Pitkänen A, Koponen E, Saarelainen T, Castrén E. 2003. Exacerbated status epilepticus and acute cell loss, but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signaling NEUROSCIENCE 122: 1081-1092. 2003

Lukasiuk K, Kontula L, Pitkänen A. 2003. cDNA profiling of epileptogenesis in the rat brain. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 17 2: 271-279. 2003

Karhunen H, Pitkänen A, Virtanen T, Gureviciene I, Pussinen R, Ylinen A, Sivenius J, Nissinen J, Jolkkonen J. 2003. Long-term functional consequences of transient occlusion of the middle cerebral artery in rats: a 1-year follow-up of the development of epileptogenesis and memory impairment in relation to sensorimotor deficits. EPILEPSY RESEARCH 54 1: 1-10. 2003

Griffin JL, Lehtimäki KK, Valonen PK, Gröhn OHJ, Kettunen MI, Ylä-Herttuala S, Pitkänen A, Nicholson JK, Kauppinen RA. 2003. Assignment of 1H nuclear magnetic resonance visible polyunsaturated fatty acids in BT4C gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death. CANCER RESEARCH 63: 3195-3201. 2003

Pitkänen A. 2002. Prevention of epileptogenesis: Levy RH, Mattson RH, Meldrum BS, Perucca E, Antiepileptic Drugs.Lippincott. 169-176. 2002

Pitkänen A. 2002. Efficacy of current antiepileptics to prevent neurodegeneration in epilepsy models. EPILEPSY RESEARCH 50 1-2: 141-160. 2002

Pitkänen A. 2002. Drug-mediated neuroprotection and anti-epileptogenesis. NEUROLOGY. SUPPLEMENT 59 5: S27-S33. 2002

Pitkänen A, Sutula TP. 2002. Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy. LANCET NEUROLOGY 1 3: 173-181. 2002

Pitkänen A, Nissinen J, Nairismägi J, Lukasiuk K, Gröhn OHJ, Miettinen R, Kauppinen R. 2002. Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy: Sutula T, Pitkänen A, Do Seizures Damage the Brain.Elsevier. Progress in Brain Research. 67-83. 2002

Pitkänen A, Kemppainen S. 2002. Comparison of the distribution of calcium-binding proteins and intrinsic connectivity in the lateral nucleus of the rat, monkey, and human amygdala. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 71 3: 369-377. 2002

Pitkanen A, Kelly JL, Amaral DG. 2002. Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the entorhinal cortex in the macaque monkey HIPPOCAMPUS 12 2: 186-205. 2002

Majak K, Pikkarainen M, Kemppainen S, Jolkkonen E, Pitkänen A. 2002. Projections from the amygdaloid complex to the claustrum and the endopiriform nucleus: a Phaseolus vulgaris leucoagglutinin study in the rat JOURNAL OF COMPARATIVE NEUROLOGY 451 3: 236-249. 2002

Lukasiuk K, Pirttilä TJ, Pitkänen A. 2002. Upregulation of cystatin C expression in the rat hippocampus during epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy. EPILEPSIA. SUPPLEMENT 43 5: 137-145. 2002

Kubová H, Druga R, Haugvicová R, Suchomelová L, Pitkanen A. 2002. Dynamic changes of status epilepticus-induced neuronal degeneration in the mediodorsal nucleus of the thalamus during postnatal development of the rat. EPILEPSIA. SUPPLEMENT 43 5: 54-60. 2002

Kemppainen S, Jolkkonen E, Pitkänen A. 2002. Projections from the posterior cortical nucleus of the amygdala to the hippocampal formation and parahippocampal region in rat. HIPPOCAMPUS 12 6: 735-755. 2002

Jutila L, Immonen A, Partanen K, Partanen J, Mervaala E, Ylinen A, Alafuzoff I, Paljärvi L, Karkola K, Vapalahti M, Pitkänen A. 2002. Neurobiology of epileptogenesis in the temporal lobe: Pickard JD, Dolenc VV, Antunes JL, Reulen H-J, Sindou M, Strong AJ, de Tribolet N, Tulleken CAF, Vapalahti M, Advances and Technical Standards in Neurosurgery.Springer. 3-22. 2002

Jolkkonen E, Miettinen R, Pikkarainen M, Pitkänen A. 2002. Projections from the amygdaloid complex to the magnocellular cholinergic basal forebrain in rat. NEUROSCIENCE 111 1: 133-149. 2002

Lähteinen S, Pitkänen A, Saarelainen T, Nissinen J, Koponen E, Castrén E. 2002. Decreased BDNF signalling in transgenic mice reduces epileptogenesis. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 15: 721-734. 2002

Lukasiuk K, Tuunanen J, Halonen T, Pitkänen A. 2001. Time course and mechanisms of amygdaloid damage after kainate-induced status epilepticus in rat. In: Turski L, Schoepp DD, Cavalheiro EA (ed.) , Excitatory Amino Acids: Ten Years Later.IOS. Biomedical and Health Research. ss. 289-297. 2001

Salmenperä T, Kälviäinen R, Partanen K, Pitkänen A. 2001. Hippocampal and amygdaloid damage in partial epilepsy A cross-sectional MRI study of 241 patients. EPILEPSY RESEARCH 46: 69-82. 2001

Pirttilä T-RM, Pitkänen A, Tuunanen J, Kauppinen RA. 2001. Ex vivo MR microimaging of neuronal damage after kainate-induced status epilepticus in rat: correlation with quantitative histology. MAGNETIC RESONANCE IN MEDICINE 46 5: 946-954. 2001

Pikkarainen M, Pitkanen A. 2001. Projections from the lateral, basal and accessory basal nuclei of the amygdala to the perirhinal and postrhinal cortices in rat CEREBRAL CORTEX (NEW YORK NY) 11 11: 1064-1082. 2001

Nissinen J, Lukasiuk K, Pitkänen A. 2001. Is mossy fiber sprouting present at the time of the first spontaneous seizures in rat experimental temporal lobe epilepsy?. HIPPOCAMPUS 11 3: 299-310. 2001

Sutula TP, Pitkänen A. 2001. More evidence for seizure-induced neuron loss: is hippocampal sclerosis both cause and effect of epilepsy? NEUROLOGY 57: 169-170. 2001

Kubová H, Druga R, Lukasiuk K, Suchomelová L, Haugvicová R, Jirmanová I, Pitkänen A. 2001. Status epilepticus causes necrotic damage in the mediodorsal nucleus of the thalamus in immature rats JOURNAL OF NEUROSCIENCE 21 10: 3593-3599. 2001

Jutila L, Immonen A, Partanen K, Partanen J, Mervaala E, Ylinen A, Alafuzoff I, Paljärvi L, Karkola K, Vapalahti M, Pitkänen A. 2001. Neurobiology of epileptogenesis in the temporal lobe: Pickard JD, Dolenc VV, Lobo Antunes J, Reulen H-J, Sindou M, Strong AJ, de Tribolet N, Tulleken CAF, Vapalahti M, Advances and Technical Standards in Neurosurgery.Springer. 4-22. 2001

Jolkkonen E, Pikkarainen M, Kemppainen S, Pitkänen A. 2001. Interconnectivity between the amygdaloid complex and the amygdalostriatal transition area: a PHA-L study in rat. JOURNAL OF COMPARATIVE NEUROLOGY 431: 39-58. 2001

Jolkkonen E, Miettinen R, Pitkänen A. 2001. Projections from the amygdalo-piriform transition area to the amygdaloid coplex: A PHA-L study in rat. JOURNAL OF COMPARATIVE NEUROLOGY 432: 440-465. 2001

Halonen T, Nissinen J, Pitkänen A. 2001. Chronic elevation of brain GABA levels beginning two days after status epilepticus does not prevent epileptogenesis in rats. NEUROPHARMACOLOGY 40 4: 536-550. 2001

Halonen T, Nissinen J, Pitkanen A. 2001. Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat. EPILEPSY RESEARCH 46 3: 205-223. 2001

Jutila L, Ylinen A, Partanen K, Alafuzoff I, Mervaala E, Partanen J, Vapalahti M, Vainio P, Pitkänen A. 2001. MR volumetry of the entorhinal, perirhinal, and temporopolar cortices in drug-refractory temporal lobe epilepsy. AJNR. AMERICAN JOURNAL OF NEURORADIOLOGY 22: 1490-1501. 2001

Pitkänen A, Nissinen J, Lukasiuk K, Jutila L, Paljärvi L, Salmenperä T, Karkola K, Vapalahti M, Ylinen A. 2000. Association between the density of mossy fiber sprouting and seizure frequency in experimental and human temporal lobe epilepsy EPILEPSIA. SUPPLEMENT 41 6: S24-S29. 2000

Tuunanen J, Pitkänen A. 2000. Do seizures cause neuronal damage in rat amygdala kindling? EPILEPSY RESEARCH 39: 171-176. 2000

Salmenperä T, Kälviäinen R, Partanen K, Pitkänen A. 2000. Quantitative MRI volumetry of the entorhinal cortex in temporal lobe epilepsy. SEIZURE 9: 208-215. 2000

Salmenperä T, Kälviäinen R, Partanen K, Mervaala E, Pitkänen A. 2000. MRI volumetry of the hippocampus, amygdala, entorhinal cortex, and perirhinal cortex after status epilepticus. EPILEPSY RESEARCH 40: 155-170. 2000

Pitkänen A. 2000. Connectivity of the rat amygdaloid complex: Aggleton JP, The Amygdala. A Functional Analysis.Oxford University Press. 31-115. 2000

Pitkänen A, Pikkarainen M, Nurminen N, Ylinen A. 2000. Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat: a review ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 911: 369-391. 2000

Mikkonen M, Pitkänen A, Soininen H, Alafuzoff I, Miettinen R. 2000. Morphology of spiny neurons in the human entorhinal cortex: intracellular filling with lucifer yellow. NEUROSCIENCE 96 3: 515-522. 2000

Pitkänen A, Jolkkonen E, Kemppainen S. 2000. Anatomic heterogeneity of the rat amygdaloid complex. FOLIA MORPHOLOGICA (PRAHA) 59 1: 1-23. 2000

Nissinen J, Halonen T, Koivisto E, Pitkänen A. 2000. A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat. EPILEPSY RESEARCH 38 2-3: 177-205. 2000

Lukasiuk K, Pitkänen A. 2000. GABA(A)-mediated toxicity of hippocampal neurons in vitro JOURNAL OF NEUROCHEMISTRY 74 6: 2445-2454. 2000

Liubashina O, Jolkkonen E, Pitkänen A. 2000. Projections from the central nucleus of the amygdala to the gastric related area of the dorsal vagal complex: a Phaseolus vulgaris-leucoagglutinin study in rat NEUROSCIENCE LETTERS 291: 85-88. 2000

Lamusuo S, Pitkänen A, Jutila L, Ylinen A, Partanen K, Kälviäinen R, Ruottinen H-M, Oikonen V, Någren K, Lehikoinen P, Vapalahti M, Vainio P, Rinne JO. 2000. [11C]Flumazenil binding in the medical temporal lobe in patients with temporal lobe epilepsy. Correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology. NEUROLOGY 54: 2252-2260. 2000

Kemppainen S, Pitkänen A. 2000. Distribution of parvalbumin, calretinin, and calbindin-D28k immunoreactivity in the rat amygdaloid complex and colocalization with gamma-aminobutyric acid JOURNAL OF COMPARATIVE NEUROLOGY 426: 441-467. 2000

Gröhn OHJ, Kettunen MI, Mäkelä HI, Penttonen M, Pitkänen A, Lukkarinen JA, Kauppinen RA. 2000. Early detection of irreversible cerebral ischemia in the rat using dispersion of the magnetic resonance imaging relaxation time, T1rho. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 20: 1457-1466. 2000

Tuunanen J, Lukasiuk K, Halonen T, Pitkänen A. 1999. Status epilepticus-induced neuronal damage in the rat amygdaloid complex: distribution, time-course and mechanisms NEUROSCIENCE 94 2: 473-495. 1999

Pitkänen A, Salmenperä T, Äikiä M, Partanen K, Kälviäinen R. 1999. Seizure-induced damage to the medial temporal lobe in temporal lobe epilepsy: Sillanpää M, Gram L, Johannessen SI, Tomson T, Epilepsy and Mental Retardation.Wrightson Biomedical Publishing . 147-163. 1999

Pikkarainen M, Rönkkö S, Savander V, Insausti R, Pitkänen A. 1999. Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the hippocampal formation in rat. JOURNAL OF COMPARATIVE NEUROLOGY 403: 229-260. 1999

Pitkänen A, Jolkkonen J. 1999. Do GABAergic circuitries play a critical role in the regulation of seizure-induced neuronal damage and synaptic reorganization in the rat hippocampus?. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY. SUPPLEMENT 50: 443-449. 1999

Pitkänen A, Nissinen J, Jolkkonen E, Tuunanen J, Halonen T. 1999. Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus. EPILEPSY RESEARCH 33: 67-85. 1999

Lehesjoki A-E, Pitkänen A. 1999. Epilepsian geenit ja neurobiologia DUODECIM 115: 583-594. 1999

Kälviäinen R, Pitkänen A. 1999. Prevention of seizure-induced neuronal damage and intellectual deterioration: experimental aspects and clinical implications. In: Sillanpää M, Gram L, Johannessen SI, Tomson T (ed.) , Epilepsy and Mental Retardation.Wrightson Biomedical Publishing . ss. 165 - 178. 1999

Jongen-Rêlo AL, Pitkänen A, Amaral DG. 1999. Distribution of GABAergic cells and fibers in the hippocampal formation of the macaque monkey: an immunohistochemical and in situ hybridization study. JOURNAL OF COMPARATIVE NEUROLOGY 408: 237-271. 1999

Halonen T, Nissinen J, Pitkänen A. 1999. Neuroprotective effect of remacemide hydrochloride in a perforant pathway stimulation model of status epilepticus in the rat. EPILEPSY RESEARCH 34: 251-269. 1999

Gröhn OHJ, Lukkarinen JA, Silvennoinen MJ, Pitkänen A, van Zijl PCM, Kauppinen RA. 1999. Quantitative magnetic resonance imaging assessment of cerebral ischemia in rat using on-resonance T1 in the rotating frame. MAGNETIC RESONANCE IN MEDICINE 42: 268-276. 1999

Sorvari H, Miettinen R, Soininen H, Paljärvi L, Karkola K, Pitkänen A. 1998. Calretinin-immunoreactive terminals make synapses on calbindin D28k-immunoreactive neurons in the lateral nucleus of the human amygdala. BRAIN RESEARCH 783: 355-358. 1998

Salmenperä T, Kälviäinen R, Partanen K, Pitkänen A. 1998. Hippocampal damage caused by seizures in temporal lobe epilepsy LANCET 351: 35. 1998

Pitkänen A. 1998. Mantelitumake DUODECIM 114: 2451-2459. 1998

Pitkänen A, Tuunanen J, Kälviäinen R, Partanen K, Salmenperä T. 1998. Amygdala damage in experimental and human temporal lobe epilepsy. EPILEPSY RESEARCH 32: 233-253. 1998

Pitkänen A, Halonen T. 1998. Prevention of epilepsy. TRENDS IN PHARMACOLOGICAL SCIENCES 19: 253-254. 1998

Pitkänen A, Amaral DG. 1998. Organization of the intrinsic connections of the monkey amygdaloid complex: projections originating in the lateral nucleus. JOURNAL OF COMPARATIVE NEUROLOGY 398: 431-458. 1998

Mikkonen M, Soininen H, Kälviäinen R, Tapiola T, Ylinen A, Vapalahti M, Paljärvi L, Pitkänen A. 1998. Remodeling of neuronal circuitries in human temporal lobe epilepsy: increased expression of highly polysialylated neural cell adhesion molecule in the hippocampus and the entorhinal cortex. ANNALS OF NEUROLOGY 44: 923-934. 1998

Kälviäinen R, Salmenperä T, Partanen K, Vainio P, Riekkinen P Sr, Pitkänen A. 1998. Recurrent seizures may cause hippocampal damage in temporal lobe epilepsy. NEUROLOGY 50: 1377-1382. 1998

Juottonen K, Laakso MP, Insausti R, Lehtovirta M, Pitkänen A, Partanen K, Soininen H. 1998. Volumes of the entorhinal and perirhinal cortices in Alzheimer`s disease NEUROBIOLOGY OF AGING 19 1: 15-22. 1998

Jolkkonen E, Pitkänen A. 1998. Intrinsic connections of the rat amygdaloid complex: projections originating in the central nucleus JOURNAL OF COMPARATIVE NEUROLOGY 395: 53-72. 1998

Insausti R, Juottonen K, Soininen H, Insausti AM, Partanen K, Vainio P, Laakso MP, Pitkänen A. 1998. MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices. AJNR. AMERICAN JOURNAL OF NEURORADIOLOGY 19: 659-671. 1998

Tuunanen J, Halonen T, Pitkänen A. 1997. Decrease in somatostatin-immunoreactive neurons in the rat amygdaloid complex in a kindling model of temporal lobe epilepsy. EPILEPSY RESEARCH 26: 315-327. 1997

Savander V, Miettinen R, Ledoux JE, Pitkänen A. 1997. Lateral nucleus of the rat amygdala is reciprocally connected with basal and accessory basal nuclei: a light and electron microscopic study. NEUROSCIENCE 77 3: 767-781. 1997

Savander V, Ledoux JE, Pitkänen A. 1997. Interamygdaloid projections of the basal and accessory basal nuclei of the rat amygdaloid complex. NEUROSCIENCE 76 3: 725-735. 1997

Pitkänen A, Savander V, Ledoux JE. 1997. Organization of intra-amygdaloid circuitries in the rat: an emerging framework for understanding functions of the amygdala. TRENDS IN NEUROSCIENCES 20 11: 517-523. 1997

Mikkonen M, Soininen H, Pitkänen A. 1997. Distribution of parvalbumin-, calretinin-, and calbindin-D28k-immunoreactive neurons and fibers in the human entorhinal cortex. JOURNAL OF COMPARATIVE NEUROLOGY 388: 64-88. 1997

Miettinen M, Pitkänen A, Miettinen R. 1997. Distribution of calretinin-immunoreactivity in the rat entorhinal cortex:coexistence with GABA JOURNAL OF COMPARATIVE NEUROLOGY 378: 363-378. 1997

Kälviäinen R, Salmenperä T, Partanen K, Vainio P, Riekkinen P Sr, Pitkänen A. 1997. MRI volumetry and T2 relaxometry of the amygdala in newly diagnosed and chronic temporal lobe epilepsy. EPILEPSY RESEARCH 28: 39-50. 1997

Kälviäinen R, Partanen K, Äikiä M, Mervaala E, Vainio P, Riekkinen PJ Sr, Pitkänen A. 1997. MRI-based hippocampal volumetry and T2 relaxometry: correlation to verbal memory performance in newly diagnosed epilepsy patients with left-sided temporal lobe focus. NEUROLOGY 48: 286-287. 1997

Jolkkonen J, Kähkönen K, Pitkänen A. 1997. Cholinergic deafferentation exacerbates seizure-induced loss of somatostatin-immunoreactive neurons in the rat hippocampus. NEUROSCIENCE 80 2: 401-411. 1997

Jolkkonen J, Jolkkonen E, Pitkänen A. 1997. Seizure-induced damage to somatostatin-immunoreactive neurons in the rat hippocampus is regulated by fimbria-fornix transection. EXPERIMENTAL NEUROLOGY 145: 141-153. 1997

Tuunanen J, Halonen T, Pitkänen A. 1996. Status epilepticus causes selective regional damage and loss of GABAergic neurons in the rat amygdaloid complex. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 8: 2711-2725. 1996

Sorvari H, Soininen H, Pitkänen A. 1996. Calretinin-immunoreactive cells and fibers in the human amygdaloid complex JOURNAL OF COMPARATIVE NEUROLOGY 369: 188-208. 1996

Sorvari H, Soininen H, Pitkänen A. 1996. Calbindin-D28K-immunoreactive cells and fibres in the human amygdaloid complex. NEUROSCIENCE 75 2: 421-443. 1996

Sorvari H, Miettinen R, Soininen H, Pitkänen A. 1996. Parvalbumin-immunoreactive neurons make inhibitory synapses on pyramidal cells in the human amygdala: a light and electron microscopic study. NEUROSCIENCE LETTERS 217: 93-96. 1996

Savander V, LeDoux JE, Pitkänen A. 1996. Topographic projections from the periamygdaloid cortex to select subregions of the lateral nucleus of the amygdala in the rat NEUROSCIENCE LETTERS 211: 167-170. 1996

Savander V, Go C-G, Ledoux JE, Pitkänen A. 1996. Intrinsic connections of the rat amygdaloid complex: projections originating in the accessory basal nucleus. JOURNAL OF COMPARATIVE NEUROLOGY 374: 291-313. 1996

Pitkänen A. 1996. Treatment with antiepileptic drugs: Possible neuroprotective effects. NEUROLOGY. SUPPLEMENT 47 1: S12-S16. 1996

Pitkänen A, Tuunanen J, Halonen T. 1996. Vigabatrin and carbamazepine have different efficacies in the prevention of status epilepticus induced neuronal damage in the hippocampus and amygdala. EPILEPSY RESEARCH 24: 29-45. 1996

Pitkänen A, Laakso M, Kälviäinen R, Partanen K, Vainio P, Lehtovirta M, Riekkinen P Sr, Soininen H. 1996. Severity of hippocampal atrophy correlates with the prolongation of MRI T2 relaxation time in temporal lobe epilepsy but not in Alzheimer's disease NEUROLOGY 46: 1724-1730. 1996

Jolkkonen J, Halonen T, Jolkkonen E, Nissinen J, Pitkänen A. 1996. Seizure-induced damage to the hippocampus is prevented by modulation of the GABAergic system. NEUROREPORT 7: 2031-2035. 1996

Halonen T, Nissinen J, Jansen JA, Pitkänen A. 1996. Tiagabine prevents seizures, neuronal damage and memory impairment in experimental status epilepticus. EUROPEAN JOURNAL OF PHARMACOLOGY 299: 69-81. 1996

Kuikka JT, Pitkänen A, Lepola U, Partanen K, Vainio P, Bergström KA, Wieler HJ, Kaiser KP, Mittelbach L, Koponen H, Leinonen E, Riekkinen PJ. 1995. Abnormal regional benzodiazepine receptor uptake in the prefrontal cortex in patients with panic disorder. NUCLEAR MEDICINE COMMUNICATIONS 16: 273-280. 1995

Pitkänen A, Stefanacci L, Farb CR, Go GG, LeDoux JE, Amaral DG. 1995. Intrinsic connections of the rat amygdaloid complex: projections originating in the lateral nucleus JOURNAL OF COMPARATIVE NEUROLOGY 356: 288-310. 1995

Pitkänen A, Tuunanen J, Halonen T. 1995. Subiculum, presubiculum and parasubiculum have different sensitivities to seizure-induced neuronal damage in the rat. NEUROSCIENCE LETTERS 192: 65-68. 1995

Savander V, Go C-G, LeDoux JE, Pitkänen A. 1995. Intrinsic connections of the rat amygdaloid complex: projections originating in the basal nucleus. JOURNAL OF COMPARATIVE NEUROLOGY 361: 345-368. 1995

Soininen H, Partanen K, Pitkänen A, Hallikainen M, Hänninen T, Helisalmi S, Mannermaa A, Ryynänen M, Koivisto K, Riekkinen P Sr. 1995. Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E epsilon 4 allele. NEUROLOGY 45: 391-392. 1995

Sorvari H, Soininen H, Paljärvi L, Karkola K, Pitkänen A. 1995. Distribution of parvalbumin-immunoreactive cells and fibers in the human amygdaloid complex JOURNAL OF COMPARATIVE NEUROLOGY 360: 185-212. 1995

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