Asla Pitkänen
Professor
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
Research groups
Projects
Publications
345/345 items-
Feature library for behavioural characterization of early and late seizures in an experimental model of post-traumatic epilepsy
Andrade, Pedro; Pitkänen, Asla, 2026, Journal of neuroscience methods, 428, 110671. A1 Journal article (refereed), original research -
Advances and challenges in experimental models of posttraumatic epilepsy for therapeutic interventions
Reddy, Doodipala Samba; Golub, Victoria M; Ramakrishnan, Sreevidya; Churn, Severn B; Shapiro, Lee A; Iannucci, Jaclyn; Pitkänen, Asla; Galanopoulou, Aristea S; Maganti, Rama; Boison, Detlev, 2025, Pharmacological reviews, 77, 5, 100080. A2 Review article, Literature review, Systematic review -
Bundle-specific tractography approach for identifying white matter microstructural changes following traumatic brain injury in rats: An EpiBioS4Rx study
Sharma, Akul; Cabeen, Ryan; Harris, Neil G; Wright, David K; Tohka, Jussi; Grohn, Olli; Bennett, Alexis; Alba, Celina; Bhagavatula, Sweta; Garner, Rachael; Asifriyaz, Tuba; Ndode-Ekane, Xavier Ekolle; Andrade, Pedro; Immonen, Riikka; Manninen, Eppu; Puhakka, Noora; Heiskanen, Mette; Ali, Idrish; Jones, Nigel C; Shultz, Sandy R; Casillas-Espinosa, Pablo M; Hudson, Matthew R; Silva, Juliana; Yamakawa, Glenn; Braine, Emma L; Smith, Gregory D; Santana-Gomez, Cesar E; Staba, Richard J; O'Brien, Teren, 2025, Imaging neuroscience, 3, imag_a_00471. A1 Journal article (refereed), original research -
Damage in thalamic projection to perilesional cortex as a prognostic biomarker for experimental post‐traumatic epilepsy
Manninen, Eppu; Cabeen, Ryan; Immonen, Riikka; Ndode‐Ekane, Xavier Ekolle; Andrade, Pedro; Harris, Neil G; Wright, David K; Tohka, Jussi; Gröhn, Olli; Pitkänen, Asla, 2025, Epilepsia, 66, 8, 2830-2841. A1 Journal article (refereed), original research -
Mitigation of Acute Seizures and Neuropathology after Traumatic Brain Injury by Structure-Based Discovery-Identified Drugs
Kajevu, Natallie; Banuelos, Ivette; Andrade, Pedro; Hämäläinen, Elina; Sabatier, Laureano; Couyoupetrou, Manuel; Villalba, María Luisa; Gavernet, Luciana; Lipponen, Anssi; Natunen, Teemu; Puhakka, Noora; Hiltunen, Mikko; Talevi, Alan; Pitkänen, Asla, 2025, Journal of neurotrauma, 42, 15-16, 1433-1452. A1 Journal article (refereed), original research -
Molecular and functional changes in GABAergic transmission during epileptogenesis in a rat model of post-traumatic epilepsy
Puhakka, Noora; Cifelli, Pierangelo; Ruffolo, Gabriele; Gaeta, Alessandro; Roseti, Cristina; De Iacovo, Angela; Tiilikainen, Johanna; Ndode-Ekane, Xavier Ekolle; Lipponen, Anssi; Drexel, Meinrad; Sperk, Günther; Pitkänen, Asla; Palma, Eleonora, 2025, Experimental neurology, 387, 115183. A1 Journal article (refereed), original research -
Standardization of preclinical methodologies for discovery and validation of circulating microRNA biomarkers for post-traumatic epileptogenesis – Lessons learned from the EpiBioS4Rx Project 1
Puhakka, Noora; Heiskanen, Mette; Ndode-Ekane, Xavier Ekolle; Ali, Idrish; Santana-Gomez, Cesar; Das Gupta, Shalini; Banerjee, Meheli; Andrade, Pedro; Immonen, Riikka; Casillas-Espinosa, Pablo; Smith, Gregory; Brady, Rhys D; Silva, Juliana; Braine, Emma; Hudson, Matthew R; Yamakawa, Glen R; Jones, Nigel C; Shultz, Sandy R; Harris, Neil G; Wright, David K; Gröhn, Olli; Staba, Richard; O’Brien, Terence J; Pitkänen, Asla, 2025, Epilepsy research, 218, 107667. A1 Journal article (refereed), original research -
Brain abscess – A rare confounding factor for diagnosis of post-traumatic epilepsy after lateral fluid-percussion injury
Kyyriäinen, Jenni; Andrade, Pedro; Ekolle Ndode-Ekane, Xavier; Manninen, Eppu; Hämäläinen, Elina; Rauramaa, Tuomas; Heiskanen, Mette; Puhakka, Noora; Immonen, Riikka; Pitkänen, Asla, 2024, Epilepsy research, 200, 107301. A1 Journal article (refereed), original research -
Circulating microRNAs and isomiRs as biomarkers for the initial insult and epileptogenesis in four experimental epilepsy models: The EPITARGET study
van Vliet, Erwin A; Scheper, Mirte; Mills, James D; Puhakka, Noora; Szydlowska, Kinga; Ferracin, Manuela; Lovisari, Francesca; Soukupova, Marie; Zucchini, Silvia; Srivastava, Prashant K; Johnson, Michael R; Lukasiuk, Katarzyna; Gorter, Jan A; Aronica, Eleonora; Pitkänen, Asla; Simonato, Michele, 2024, Epilepsia, 65, 11, 3406-3420. A1 Journal article (refereed), original research -
Plasma microRNAs as prognostic biomarkers for development of severe epilepsy after experimental traumatic brain injury —EpiBioS4Rx Project 1 study
Heiskanen, Mette; Ndode‐Ekane, Xavier Ekolle; Ali, Idrish; Santana‐Gomez, Cesar; Puhakka, Noora; Gupta, Shalini Das; Andrade, Pedro; Immonen, Riikka; Casillas‐Espinosa, Pablo; Manninen, Eppu; Smith, Gregory; Brady, Rhys D.; Silva, Juliana; Braine, Emma; Hudson, Matt; Yamakawa, Glen R.; Jones, Nigel C.; Shultz, Sandy R.; Harris, Neil G.; Wright, David K.; Gröhn, Olli; Staba, Richard J.; O'Brien, Terence J.; Pitkänen, Asla, 2024, Epilepsia, 66, 3, 870-885. A1 Journal article (refereed), original research -
Plasma neurofilament heavy chain is a prognostic biomarker for the development of severe epilepsy after experimental traumatic brain injury
Heiskanen, Mette; Banuelos, Ivette; Manninen, Eppu; Andrade, Pedro; Hämäläinen, Elina; Puhakka, Noora; Pitkänen, Asla, 2024, Epilepsia, 65, 12, 3703-3716. A1 Journal article (refereed), original research -
Discovery and Validation of Circulating microRNAs as Biomarkers for Epileptogenesis after Experimental Traumatic Brain Injury–The EPITARGET Cohort
Heiskanen, Mette; Das Gupta, Shalini; Mills, James D; van Vliet, Erwin A; Manninen, Eppu; Ciszek, Robert; Andrade, Pedro; Puhakka, Noora; Aronica, Eleonora; Pitkänen, Asla, 2023, International journal of molecular sciences, 24, 3, 2823. A1 Journal article (refereed), original research -
Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1
Ndode‐Ekane, Xavier Ekolle; Ali, Idrish; Santana‐Gomez, Cesar; Andrade, Pedro; Immonen, Riikka; Casillas‐Espinosa, Pablo; Paananen, Tomi; Manninen, Eppu; Puhakka, Noora; Smith, Gregory; Brady, Rhys D; Silva, Juliana; Braine, Emma; Hudson, Matt; Yamakawa, Glen R; Jones, Nigel C; Shultz, Sandy R; Harris, Neil; Wright, David K; Gröhn, Olli; Staba, Richard; O'Brien, Terence J; Pitkänen, Asla, 2023, Epilepsia, 65, 2, 511-526. A1 Journal article (refereed), original research -
Gene Expression Profile as a Predictor of Seizure Liability
Lipponen, Anssi; Kajevu, Natallie; Natunen, Teemu; Ciszek, Robert; Puhakka, Noora; Hiltunen, Mikko; Pitkänen, Asla, 2023, International journal of molecular sciences, 24, 4, 4116. A1 Journal article (refereed), original research -
Highlights From the Annual Meeting of the American Epilepsy Society 2022
Valencia, Ignacio; Alexander, Allyson L.; Andrade, Danielle M.; Arevalo-Astrada, Miguel; Rubiños, Clio; Auer, Nancy; Bainbridge, Jacquelyn L.; Baxendale, Sallie A.; Bartolomei, Fabrice; Becker, Danielle A.; Berg, Anne T.; Bernasconi, Andrea; Bernasconi, Neda; Bernhardt, Boris; Bhatnagar, Shivani; Blümcke, Ingmar; Blumenfeld, Hal; Buchanan, Gordon F.; Burdette, David E.; Burneo, Jorge G.; Busch, Robyn M.; Chauvel, Patrick; Chin, Jeannie; Clifford, Lisa; Conner, Kelly R.; Cook, Mark J.; Conway, Je, 2023, Epilepsy currents, [Epub ahead of print 16 Aug 2023], 1-36. B1 Non-refereed journal articles -
Image data harmonization tools for the analysis of post-traumatic epilepsy development in preclinical multisite MRI studies
Bhagavatula, Sweta; Cabeen, Ryan; Harris, Neil G.; Gröhn, Olli; Wright, David K.; Garner, Rachael; Bennett, Alexis; Alba, Celina; Martinez, Aubrey; Ndode-Ekane, Xavier Ekolle; Andrade, Pedro; Paananen, Tomi; Ciszek, Robert; Immonen, Riikka; Manninen, Eppu; Puhakka, Noora; Tohka, Jussi; Heiskanen, Mette; Ali, Idrish; Shultz, Sandy R.; Casillas-Espinosa, Pablo M.; Yamakawa, Glenn R.; Jones, Nigel C.; Hudson, Matthew R.; Silva, Juliana C.; Braine, Emma L.; Brady, Rhys D.; Santana-Gomez, Cesar E.; S, 2023, Epilepsy research, 195, 107201. A1 Journal article (refereed), original research -
Proteomics of Deep Cervical Lymph Nodes After Experimental Traumatic Brain Injury
Puhakka, Noora; Das Gupta, Shalini; Leskinen, Sara; Heiskanen, Mette; Nattinen, Janika; Aapola, Ulla; Uusitalo, Hannu; Pitkanen, Asla, 2023, Neurotrauma reports, 4, 1, 359-366. A1 Journal article (refereed), original research -
Sleep Disturbance and Severe Hydrocephalus in a Normally Behaving Wistar Rat With Traumatic Brain Injury
Kyyriäinen, Jenni; Andrade, Pedro; Hämäläinen, Elina; Pitkänen, Asla, 2023, Neurotrauma reports, 4, 1, 384-395. A1 Journal article (refereed), original research -
Successful harmonization in EpiBioS4Rx biomarker study on post-traumatic epilepsy paves the way towards powered preclinical multicenter studies
Ndode-Ekane, Xavier Ekolle; Ali, Idrish; Santana-Gomez, Cesar E; Casillas-Espinosa, Pablo M; Andrade, Pedro; Smith, Gregory; Paananen, Tomi; Manninen, Eppu; Immonen, Riikka; Puhakka, Noora; Ciszek, Robert; Hämäläinen, Elina; Brady, Rhys D; Silva, Juliana; Braine, Emma; Hudson, Matthew R; Yamakawa, Glenn; Jones, Nigel C; Shultz, Sandy R; Wright, David; Harris, Neil; Gröhn, Olli; Staba, Richard J; O’Brien, Terence J; Pitkänen, Asla, 2023, Epilepsy research, 199, 107263. A1 Journal article (refereed), original research -
Treatment of Status Epilepticus after Traumatic Brain Injury Using an Antiseizure Drug Combined with a Tissue Recovery Enhancer Revealed by Systems Biology
Kajevu, Natallie; Lipponen, Anssi; Andrade, Pedro; Bañuelos, Ivette; Puhakka, Noora; Hämäläinen, Elina; Natunen, Teemu; Hiltunen, Mikko; Pitkänen, Asla, 2023, International journal of molecular sciences, 24, 18, 14049. A1 Journal article (refereed), original research -
Acute Hippocampal Damage as a Prognostic Biomarker for Cognitive Decline but Not for Epileptogenesis after Experimental Traumatic Brain Injury
Manninen, Eppu; Chary, Karthik; De Feo, Riccardo; Hämäläinen, Elina; Andrade, Pedro; Paananen, Tomi; Sierra, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkänen, Asla, 2022, Biomedicines, 10, 11, 2721. A1 Journal article (refereed), original research -
Chronic hypometabolism in striatum and hippocampal network after traumatic brain injury and their relation with memory impairment – [18F]-FDG-PET and MRI 4 months after fluid percussion injury in rat
Yasmin, Amna; Jokivarsi, Kimmo; Poutiainen, Pekka; Pitkänen, Asla; Gröhn, Olli; Immonen, Riikka, 2022, Brain research, 1788, 147934. A1 Journal article (refereed), original research -
Convolutional Neural Networks Enable Robust Automatic Segmentation of the Rat Hippocampus in MRI After Traumatic Brain Injury
De Feo, Riccardo; Hämäläinen, Elina; Manninen, Eppu; Immonen, Riikka; Valverde, Juan Miguel; Ndode-Ekane, Xavier Ekolle; Gröhn, Olli; Pitkänen, Asla; Tohka, Jussi, 2022, Frontiers in neurology, 13, 820267. A1 Journal article (refereed), original research -
Effect of cell culture media on extracellular vesicle secretion from mesenchymal stromal cells and neurons
Karttunen, Jenni; Heiskanen, Mette; Joki, Tiina; Hyysalo, Anu; Navarro-Ferrandis, Vicente; Miettinen, Susanna; Narkilahti, Susanna; Pitkänen, Asla, 2022, European journal of cell biology, 101, 4, 151270. A1 Journal article (refereed), original research -
Hippocampal position and orientation as prognostic biomarkers for posttraumatic epileptogenesis: An experimental study in a rat lateral fluid percussion model
De Feo, Riccardo; Manninen, Eppu; Chary, Karthik; Hämäläinen, Elina; Immonen, Riikka; Andrade, Pedro; Ndode‐Ekane, Xavier Ekolle; Gröhn, Olli; Pitkänen, Asla; Tohka, Jussi, 2022, Epilepsia, 63, 7, 1849-1861. A1 Journal article (refereed), original research -
International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke
Mishra, Nishant K.; Engel, Jerome; Liebeskind, David S.; Sharma, Vijay K.; Hirsch, Lawrence J.; Kasner, Scott E; French, Jacqueline A.; Devinsky, Orrin; Friedman, Alon; Dawson, Jesse; Quinn, Terence J.; Selim, Magdy; de Havenon, Adam; Yasuda, Clarissa L.; Cendes, Fernando; Benninger, Felix; Zaveri, Hitten P.; Burneo, Jorge G.; Srivastava, Padma; Bhushan Singh, Mamta; Bhatia, Rohit; Vishnu, V.Y.; Bentes, Carla; Ferro, Jose; Weiss, Shennan; Sivaraju, Adithya; Kim, Jennifer A.; Galovic, Marian; Gil, 2022, Epilepsy & behavior, 127, 108502. B1 Non-refereed journal articles -
MRI-Guided Electrode Implantation for Chronic Intracerebral Recordings in a Rat Model of Post−Traumatic Epilepsy—Challenges and Gains
Ndode-Ekane, Xavier Ekolle; Immonen, Riikka; Hämäläinen, Elina; Manninen, Eppu; Andrade, Pedro; Ciszek, Robert; Paananen, Tomi; Gröhn, Olli; Pitkänen, Asla, 2022, Biomedicines, 10, 9, 2295. A1 Journal article (refereed), original research -
Plasma Neurofilament Light Chain (NF-L) Is a Prognostic Biomarker for Cortical Damage Evolution but Not for Cognitive Impairment or Epileptogenesis Following Experimental TBI
Heiskanen, Mette; Jääskeläinen, Olli; Manninen, Eppu; Das Gupta, Shalini; Andrade, Pedro; Ciszek, Robert; Gröhn, Olli; Herukka, Sanna-Kaisa; Puhakka, Noora; Pitkänen, Asla, 2022, International journal of molecular sciences, 23, 23, 15208. A1 Journal article (refereed), original research -
Seizure Susceptibility and Sleep Disturbance as Biomarkers of Epileptogenesis after Experimental TBI
Andrade, Pedro; Lara-Valderrábano, Leonardo; Manninen, Eppu; Ciszek, Robert; Tapiala, Jesse; Ndode-Ekane, Xavier Ekolle; Pitkänen, Asla, 2022, Biomedicines, 10, 5, 1138. A1 Journal article (refereed), original research -
Shaping the future of European epilepsy research: Final meeting report from EPICLUSTER
Henshall, David C.; Arzimanoglou, Alexis; Dedeurwaerdere, Stefanie; Guerrini, Renzo; Jozwiak, Sergiusz; Kokaia, Merab; Lerche, Holger; Pitkänen, Asla; Ryvlin, Philippe; Simonato, Michele; Sisodiya, Sanjay M., 2022, Epilepsy research, 189, 107068. B1 Non-refereed journal articles -
Transfer RNA-Derived Fragments and isomiRs Are Novel Components of Chronic TBI-Induced Neuropathology
Puhakka, Noora; Das Gupta, Shalini; Vuokila, Niina; Pitkänen, Asla, 2022, Biomedicines, 10, 1, 136. A1 Journal article (refereed), original research -
Ultrasonic vocalizations – Novel seizure-related manifestation in rats
Lara-Valderrábano, Leonardo; Ciszek, Robert; Bañuelos-Cabrera, Ivette; Andrade, Pedro; Pitkänen, Asla, 2022, Epilepsy research, 183, 106927. A1 Journal article (refereed), original research -
Acute thalamic damage as a prognostic biomarker for post-traumatic epileptogenesis
Manninen, Eppu; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkänen, Asla, 2021, Epilepsia, 62, 8, 1852-1864. A1 Journal article (refereed), original research -
Biomarkers for posttraumatic epilepsy
Pitkänen, Asla; Paananen, Tomi; Kyyriäinen, Jenni; Das Gupta, Shalini; Heiskanen, Mette; Vuokila, Niina; Bañuelos-Cabrera, Ivette; Lapinlampi, Niina; Kajevu, Natallie; Andrade, Pedro; Ciszek, Robert; Lara-Valderrábano, Leonardo; Ekolle Ndode-Ekane, Xavier; Puhakka, Noora, 2021, Epilepsy & behavior, 121, Part B, 107080. A2 Review article, Literature review, Systematic review -
Climate change and epilepsy: Insights from clinical and basic science studies
Gulcebi, Medine I; Bartolini, Emanuele; Lee, Omay; Lisgaras, Christos Panagiotis; Onat, Filiz; Mifsud, Janet; Striano, Pasquale; Vezzani, Annamaria; Hildebrand, Michael S; Jimenez-Jimenez, Diego; Junck, Larry; Lewis-Smith, David; Scheffer, Ingrid E; Thijs, Roland D; Zuberi, Sameer M; Blenkinsop, Stephen; Fowler, Hayley J; Foley, Aideen; Sisodiya, Sanjay M; Balestrini, Simona et al. [incl. Pitkänen, Asla], 2021, Epilepsy & behavior, 116, 107791. A2 Review article, Literature review, Systematic review -
Identification of clinically relevant biomarkers of epileptogenesis - a strategic roadmap
Simonato, Michele; Agoston, Denes V; Brooks-Kayal, Amy; Dulla, Chris; Fureman, Brandy; Henshall, David C; Pitkänen, Asla; Theodore, William H; Twyman, Roy E; Kobeissy, Firas H; Wang, Kevin K; Whittemore, Vicky; Wilcox, Karen S, 2021, Nature reviews neurology, 17, 4, 231-242. A2 Review article, Literature review, Systematic review -
Meeting report: EpiXchange II brings together European epilepsy research projects to discuss latest advances
Henshall, David C.; Guerrini, Renzo; Jozwiak, Sergiusz; Kokaia, Merab; Pitkanen, Asla; Sisodiya, Sanjay; Simonato, Michele; Cross, J. Helen; Ryvlin, Philippe; Brodie, Martin J.; Trinka, Eugen; Sofia, Francesca, 2021, Epilepsy research, 178, 106811. B1 Non-refereed journal articles -
Novel Approaches to Prevent Epileptogenesis After Traumatic Brain Injury
Dulla, Chris G.; Pitkänen, Asla, 2021, Neurotherapeutics, 18, 3, 1582-1601. A2 Review article, Literature review, Systematic review -
Peripheral Infection after Traumatic Brain Injury Augments Excitability in the Perilesional Cortex and Dentate Gyrus
Wang, Ying; Andrade, Pedro; Pitkänen Asta, 2021, Biomedicines, 9, 12, 1946. A1 Journal article (refereed), original research -
Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury
Das Gupta, Shalini; Ciszek, Robert; Heiskanen, Mette; Lapinlampi, Niina; Kukkonen, Janne; Leinonen, Ville; Puhakka, Noora; Pitkänen, Asla, 2021, International journal of molecular sciences, 22, 4, 1563. A1 Journal article (refereed), original research -
Post-injury ventricular enlargement associates with iron in choroid plexus but not with seizure susceptibility nor lesion atrophy - 6-month MRI follow-up after experimental traumatic brain injury
Yasmin, Amna; Pitkänen, Asla; Andrade, Pedro; Paananen, Tomi; Gröhn, Olli; Immonen, Riikka, 2021, Brain structure and function, 2022; 227, 1, 145-158. A1 Journal article (refereed), original research -
Regulation of parvalbumin interactome in the perilesional cortex after experimental traumatic brain injury
Hiltunen, Johanna; Ndode-Ekane, Xavier Ekolle; Lipponen, Anssi; Drexel, Meinrad; Sperk, Günther; Puhakka, Noora; Pitkänen, Asla, 2021, Neuroscience, 475, 52-72. A1 Journal article (refereed), original research -
Reorganization of Thalamic Inputs to Lesioned Cortex Following Experimental Traumatic Brain Injury
Ndode-Ekane, Xavier Ekolle; Puigferrat Pérez, Maria del Mar; Di Sapia, Rossella; Lapinlampi, Niina; Pitkänen, Asla, 2021, International journal of molecular sciences, 22, 12, 6329. A1 Journal article (refereed), original research -
Targeting Oxidative Stress with Antioxidant Duotherapy after Experimental Traumatic Brain Injury
Kyyriäinen, Jenni; Kajevu, Natallie; Bañuelos, Ivette; Lara, Leonardo; Lipponen, Anssi; Balosso, Silvia; Hämäläinen, Elina; Das Gupta, Shalini; Puhakka, Noora; Natunen, Teemu; Ravizza, Teresa; Vezzani, Annamaria; Hiltunen, Mikko; Pitkänen, Asla, 2021, International journal of molecular sciences, 22, 19, 10555. A1 Journal article (refereed), original research -
Voiko epilepsian puhkeamisen ja etenemisen estää lääkehoidolla?
Pitkänen, Asla, 2021, Duodecim, 137, 16, 1631 - 1637. A2 Review article, Literature review, Systematic review -
A Computational Diffusion MRI Framework for Biomarker Discovery in a Rodent Model of Post-Traumatic Epileptogenesis
Cabeen, Ryan P; Immonen, Riikka; Harris, Neil G; Gröhn, Olli; Smith, Gregory; Manninen, Eppu; Garner, Rachael; Duncan, Dominique; Pitkänen, Asla; Toga, Arthur W, 2020, -, 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI), 1013-1017, IEEE international symposium on biomedical imaging. A4 Conference proceedings -
Biomarkers For Epileptogenesis And Its Treatment
Engel, Jerome Jr; Pitkänen, Asla, 2020, Neuropharmacology, 167, 107735. A2 Review article, Literature review, Systematic review -
Chronic Regulation of miR-124-3p in the Perilesional Cortex After Experimental and Human TBI
Vuokila, Niina; Aronica, Eleonora; Korotkov, Anatoly; van Vliet, Erwin Alexander; Nuzhat, Salma; Puhakka, Noora; Pitkänen, Asla, 2020, International journal of molecular sciences, 21, 7, 2418. A1 Journal article (refereed), original research -
Droplet digital polymerase chain reaction-based quantification of circulating microRNAs using small RNA concentration normalization
Das Gupta, Shalini; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Pitkänen, Asla, 2020, Scientific reports, 10, 9012. A1 Journal article (refereed), original research -
Early increase in cortical T2 relaxation is a prognostic biomarker for the evolution of severe cortical damage, but not for epileptogenesis, after experimental traumatic brain injury
Manninen, Eppu Matias; Chary, Karthik; Lapinlampi, Niina; Andrade, Pedro; Paananen, Tomi; Sierra Lopez, Alejandra; Tohka, Jussi; Gröhn, Olli; Pitkanen, Asla, 2020, Journal of neurotrauma, 37, 23, 2580-2594. A1 Journal article (refereed), original research -
Elevated acute plasma miR-124-3p level relates to evolution of larger cortical lesion area after traumatic brain injury
Vuokila, Niina; Gupta, Shalini Das; Huusko, Riina; Tohka, Jussi; Puhakka, Noora; Pitkänen, Asla, 2020, Neuroscience, 433, 21-35. A1 Journal article (refereed), original research -
Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation
Korotkov, Anatoly; Puhakka, Noora; Gupta, Shalini Das; Vuokila, Niina; Broekaart, Diede W M; Anink, Jasper J; Heiskanen, Mette; Karttunen, Jenni; van Scheppingen, Jackelien; Huitinga, Inge; Mills, James D; van Vliet, Erwin A; Pitkänen, Asla; Aronica, Eleonora, 2020, Brain pathology, 30, 5, 897-912. A1 Journal article (refereed), original research -
Kainate receptors regulate development of glutamatergic synaptic circuitry in the rodent amygdala
Ryazantseva, Maria; Englund, Jonas; Shintyapina, Alexandra; Huupponen, Johanna; Shteinikov, Vasilii; Pitkänen, Asla; Partanen, Juha; Lauri, Sari, 2020, eLife, 9, e52798. A1 Journal article (refereed), original research -
LifeTime and improving European healthcare through cell-based interceptive medicine
Rajewsky, Nikolaus; Almouzni, Geneviève; Gorski, Stanislaw A; Aerts, Stein; Amit, Ido; Bertero, Michela G; Bock, Christoph; Bredenoord, Annelien L; Cavalli, Giacomo; Chiocca, Susanna; Clevers, Hans; Strooper, Bart De; Eggert, Angelika; Ellenberg, Jan; Fernández, Xosé M; Figlerowicz, Marek; Gasser, Susan M; Hubner, Norbert; Kjems, Jørgen; Knoblich, Jürgen A et al. [incl. Pitkänen, Asla; Leinonen, Ville], 2020, Nature, 587, 377-386. A1 Journal article (refereed), original research -
Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury
van Vliet, Erwin A; Ndode-Ekane, Xavier Ekolle; Lehto, Lauri J; Gorter, Jan A; Andrade, Pedro; Aronica, Eleonora; Gröhn, Olli; Pitkänen, Asla, 2020, Neurobiology of disease, 145, 1-20. A1 Journal article (refereed), original research -
Plau/Plaur double-deficiency did not worsen lesion severity or vascular integrity after traumatic brain injury
Kyyriäinen, Jenni; Tapiala, Jesse; Lipponen, Anssi; Ekolle Ndode-Ekane, Xavier; Pitkänen, Asla, 2020, Neuroscience letters, 729, 134935. A1 Journal article (refereed), original research -
Postinjury weight rather than cognitive or behavioral impairment predicts development of posttraumatic epilepsy after lateral fluid-percussion injury in rats
Lapinlampi, N; Andrade, P; Paananen, T; Hämäläinen, E; Ekolle Ndode-Ekane, X; Puhakka, N; Pitkänen, A, 2020, Epilepsia, 61, 9, 2035-2052. A1 Journal article (refereed), original research -
Acute downregulation of novel hypothalamic protein sushi repeat-containing protein X-Linked 2 (SRPX2) after experimental traumatic brain injury
Anwer, Mehwish; Lara-Valderrabano, Leonardo; Karttunen, Jenni; Ndode-Ekane, Xavier Ekolle; Puhakka, Noora; Pitkänen, Asla, 2019, Journal of neurotrauma, 2020; 37, 7, 924-938. A1 Journal article (refereed), original research -
Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats
Andrade, Pedro; Banuelos-Cabrera, Ivette; Lapinlampi, Niina; Paananen, Tomi; Ciszek, Robert; Ndode-Ekane, Xavier Ekolle; Pitkanen, Asla, 2019, Journal of neurotrauma, 36, 11, 1890-1907. A1 Journal article (refereed), original research -
Advancing research toward faster diagnosis, better treatment, and end of stigma in epilepsy
Pitkänen, A; Henshall, DC; Cross, JH; Guerrini, R; Jozwiak, S; Kokaia, M; Simonato, M; Sisodiya, S; Mifsud, J, 2019, Epilepsia, 60, 7, 1281-1292. A2 Review article, Literature review, Systematic review -
Common data elements (CDEs) for preclinical epilepsy research: Introduction to CDEs and description of core CDEs. A TASK3 report of the ILAE/AES joint translational task force
Harte-Hargrove, Lauren C; Galanopoulou, Aristea S; French, Jacqueline A; Pitkänen, Asla; Whittemore, Vicky; Scharfman, Helen E, 2019, Epilepsia open, 3, S1, 13-23. A1 Journal article (refereed), original research -
Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility
Kyyriäinen, J; Bolkvadze, T; Koivisto, H; Lipponen, A; Pérez, LO; Ekolle Ndode-Ekane, X; Tanila, H; Pitkänen, A, 2019, Epilepsy research, 151, 67-74. A1 Journal article (refereed), original research -
Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury
Das Gupta, S; Lipponen, A; Paldanius, KMA; Puhakka, N; Pitkänen, A, 2019, Scientific reports, 9, 20208. A1 Journal article (refereed), original research -
Epilepsy biomarkers - Toward etiology and pathology specificity
Pitkänen, Asla; Ekolle, Ndode-Ekane Xavier; Lapinlampi, Niina; Puhakka, Noora, 2019, Neurobiology of disease, 123, 42-58. A2 Review article, Literature review, Systematic review -
Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies
Karttunen, J; Heiskanen, M; Lipponen, A; Poulsen, D; Pitkänen, A, 2019, International journal of molecular sciences, 20, 6, 1259. A2 Review article, Literature review, Systematic review -
Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2)
Anwer, M; Bolkvadze, T; Puhakka, N; Ndode-Ekane, XE; Pitkänen, A, 2019, Neuroscience, 415, 184-200. A1 Journal article (refereed), original research -
Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis
Ndode-Ekane, XE; Santana-Gomez, C; Casillas-Espinosa, PM; Ali, I; Brady, RD; Smith, G; Andrade, P; Immonen, R; Puhakka, N; Hudson, MR; Braine, EL; Shultz, SR; Staba, RJ; O'Brien, TJ; Pitkänen, A, 2019, Epilepsy research, 151, 7-16. A1 Journal article (refereed), original research -
Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis
Santana-Gomez, C; Andrade, P; Hudson, MR; Paananen, T; Ciszek, R; Smith, G; Ali, I; Rundle, BK; Ndode-Ekane, XE; Casillas-Espinosa, PM; Immonen, R; Puhakka, N; Jones, N; Brady, RD; Perucca, P; Shultz, SR; Pitkänen, A; O'Brien, TJ; Staba, R, 2019, Epilepsy research, 156, 106110. A1 Journal article (refereed), original research -
Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis
Immonen, R; Smith, G; Brady, RD; Wright, D; Johnston, L; Harris, NG; Manninen, E; Salo, R; Branch, C; Duncan, D; Cabeen, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Shultz, SR; Andrade, P; Puhakka, N; Staba, RJ; O'Brien, TJ; et al., 2019, Epilepsy research, 150, 46-57. A1 Journal article (refereed), original research -
Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis
Casillas-Espinosa, PM; Andrade, P; Santana-Gomez, C; Paananen, T; Smith, G; Ali, I; Ciszek, R; Ndode-Ekane, XE; Brady, RD; Tohka, J; Hudson, MR; Perucca, P; Braine, EL; Immonen, R; Puhakka, N; Shultz, SR; Jones, NC; Staba, RJ; Pitkänen, A; O'Brien, TJ, 2019, Epilepsy research, 156, 106131. A1 Journal article (refereed), original research -
In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury - Lessons Learned
Lipponen, A; Natunen, T; Hujo, M; Ciszek, R; Hämäläinen, E; Tohka, J; Hiltunen, M; Paananen, J; Poulsen, D; Kansanen, E; Ekolle Ndode-Ekane, X; Levonen, AL; Pitkänen, A, 2019, International journal of molecular sciences, 20, 21, 5395. A1 Journal article (refereed), original research -
Lateral fluid-percussion injury leads to pituitary atrophy in rats
Anwer, M; Immonen, R; Hayward, NMEA; Ndode-Ekane, XE; Puhakka, N; Gröhn, O; Pitkänen, A, 2019, Scientific reports, 9, 1, 11819. A1 Journal article (refereed), original research -
MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex - A 6-Months Multimodal Imaging Follow-Up Study
Yasmin, Amna; Pitkänen, Asla; Jokivarsi, Kimmo; Poutiainen, Pekka; Gröhn, Olli; Immonen, Riikka, 2019, Frontiers in neuroscience, 13, 863. A1 Journal article (refereed), original research -
Preclinical common data elements (CDEs) for epilepsy: A joint ILAE/AES and NINDS translational initiative
Scharfman, Helen E; Galanopoulou, Aristea S; French, Jacqueline A; Pitkänen, Asla; Whittemore, Vicky; Harte-Hargrove, Lauren C, 2019, Epilepsia open, 3, 9-12. B1 Non-refereed journal articles -
Preface - Practical and theoretical considerations for performing a multi-center preclinical biomarker discovery study of post-traumatic epileptogenesis: lessons learned from the EpiBioS4Rx consortium
Pitkänen, Asla; O'Brien, Terence J; Staba, Richard, 2019, Epilepsy research, 156, 1-4. A1 Journal article (refereed), original research -
Visualization of thalamic calcium influx with quantitative susceptibility mapping as a potential imaging biomarker for repeated mild traumatic brain injury
Schweser, F; Kyyriäinen, J; Preda, M; Pitkänen, A; Toffolo, K; Poulsen, A; Donahue, K; Levy, B; Poulsen, D, 2019, Neuroimage, 200, 250-258. A1 Journal article (refereed), original research -
Web Application for Quantification of Traumatic Brain Injury-Induced Cortical Lesions in Adult Mice
Ciszek, R; Andrade, P; Tapiala, J; Pitkänen, A; Ndode-Ekane, XE, 2019, Neuroinformatics, 2020; 18, 307-317. A1 Journal article (refereed), original research -
A web-based application for generating 2D-unfolded cortical maps to analyze the location and extent of cortical lesions following traumatic brain injury in adult rats
Andrade, Pedro; Ciszek, Robert; Pitkänen, Asla; Ndode-Ekane, Xavier Ekolle, 2018, Journal of neuroscience methods, 308, 330-336. A1 Journal article (refereed), original research -
Algorithm for automatic detection of spontaneous seizures in rats with post-traumatic epilepsy
Andrade, Pedro; Paananen, Tomi; Ciszek, Robert; Lapinlampi, Niina; Pitkänen, Asla, 2018, Journal of neuroscience methods, 307, 37-45. A1 Journal article (refereed), original research -
Analytic Tools for Post-traumatic Epileptogenesis Biomarker Search in Multimodal Dataset of an Animal Model and Human Patients
Duncan, Dominique; Barisano, Giuseppe; Cabeen, Ryan; Sepehrband, Farshid; Garner, Rachael; Braimah, Adebayo; Vespa, Paul; Pitkänen, Asla; Law, Meng; Toga, Arthur W, 2018, Frontiers in neuroscience, 12, 86. A1 Journal article (refereed), original research -
Big data sharing and analysis to advance research in post-traumatic epilepsy
Duncan, Dominique; Vespa, Paul; Pitkanen, Asla; Braimah, Adebayo; Lapinlampi, Niina; Toga, Arthur W, 2018, Neurobiology of disease, 2019; 123, 127-136. A2 Review article, Literature review, Systematic review -
Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury
Huttunen, JK; Airaksinen, AM; Barba, C; Colicchio, G; Niskanen, JP; Shatillo, A; Sierra Lopez, A; Ndode-Ekane, XE; Pitkanen, A; Gröhn, O, 2018, Journal of neurotrauma, 35, 22, 2708-2717. A1 Journal article (refereed), original research -
Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study
Tubi, MA; Lutkenhoff, E; Blanco, MB; McArthur, D; Villablanca, P; Ellingson, B; Diaz-Arrastia, R; Van Ness, P; Real, C; Shrestha, V; Engel, J; Jr; Vespa, PM; Agoston, D; Au, A; Bell, MJ; Bleck, T; Branch, C; Buitrago Blanco, M; Bullock, R; Burrows, BT; et al.; EpiBioS4Rx Study Group Investigators (incl. Pitkänen, Asla), 2018, Neurobiology of disease, 2019; 123, 115-121. A2 Review article, Literature review, Systematic review -
Epilepsy in neuropathologically verified Alzheimer's disease
Rauramaa, T; Saxlin, A; Lohvansuu, K; Alafuzoff, I; Pitkänen, A; Soininen, H, 2018, Seizure: european journal of epilepsy, 58, 9-12. A1 Journal article (refereed), original research -
Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis
Kamnaksh, A; Puhakka, N; Ali, I; Smith, G; Aniceto, R; McCullough, J; Das Gupta, S; Ndode-Ekane, XE; Brady, R; Casillas-Espinosa, P; Hudson, M; Santana-Gomez, C; Immonen, R; Abreu, PA; Jones, N; Shultz, S; Staba, RJ; O'Brien, TJ; Agoston, D; Pitkänen, A, 2018, Epilepsy research, 2019; 149, 92-101. A1 Journal article (refereed), original research -
Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis
Ciszek, R; Ndode-Ekane, XE; Gomez, CS; Casillas-Espinosa, PM; Ali, I; Smith, G; Puhakka, N; Lapinlampi, N; Andrade, P; Kamnaksh, A; Immonen, R; Paananen, T; Hudson, MR; Brady, RD; Shultz, SR; O'Brien, TJ; Staba, RJ; Tohka, J; Pitkänen, A, 2018, Epilepsy research, 2019; 150, 17-26. A1 Journal article (refereed), original research -
Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs
Karttunen, Jenni; Heiskanen, Mette; Navarro-Ferrandis, Vicente; Das Gupta, Shalini; Lipponen, Anssi; Puhakka, Noora; Rilla, Kirsi; Koistinen, Arto; Pitkänen, Asla, 2018, Journal of extracellular vesicles, 2019; 8, 1, 1555410. A1 Journal article (refereed), original research -
Sushi repeat-containing protein X-Linked 2 - a novel phylogenetically conserved hypothalamo-pituitary protein
Anwer, M; Bolkvadze, T; Ndode-Ekane, XE; Puhakka, N; Rauramaa, T; Leinonen, V; van Vliet, EA; Swaab, DF; Haapasalo, A; Leskelä, S; Bister, N; Malm, T; Carlson, S; Aronica, E; Pitkänen, A, 2018, Journal of comparative neurology, 526, 11, 1806-1819. A1 Journal article (refereed), original research -
T-cell infiltration into the perilesional cortex is long-lasting and associates with poor somatomotor recovery after experimental traumatic brain injury
Ndode-Ekane, Xavier Ekolle; Matthiesen, Liz; Bañuelos-Cabrera, Ivette; Palminha, Cátia Alexandra Pegas; Pitkänen, Asla, 2018, Restorative neurology and neuroscience, 36, 4, 485-501. A1 Journal article (refereed), original research -
Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury
Lipponen, Anssi; El-Osta, Assam; Kaspi, Antony; Ziemann, Mark; Khurana, Ishant; Harikrishnan, K N; Navarro-Ferrandis, Vicente; Puhakka, Noora; Paananen, Jussi; Pitkänen, Asla, 2018, Acta neuropathologica communications, 6, 17. A1 Journal article (refereed), original research -
miR-124-3p is a chronic regulator of gene expression after brain injury
Vuokila, Niina; Lukasiuk, Katarzyna; Bot, Anna Maria; van Vliet, Erwin A; Aronica, Eleonora; Pitkänen, Asla; Puhakka Niina, 2018, Cellular and molecular life sciences, 75, 24, 4557-4581. A1 Journal article (refereed), original research -
Chronically dysregulated NOTCH1 interactome in the dentate gyrus after traumatic brain injury
Puhakka Noora, Bot Anna Maria, Vuokila Niina, Debski Konrad Jozef, Lukasiuk Katarzyna, Pitkänen Asla, 2017, PLoS ONE, 12, 3, e0172521. A1 Journal article (refereed), original research -
Common data elements for preclinical epilepsy research: Standards for data collection and reporting. A TASK3 report of the AES/ILAE Translational Task Force of the ILAE
Harte-Hargrove LC, French JA, Pitkänen A, Galanopoulou AS, Whittemore V, Scharfman HE, 2017, Epilepsia, 58, Suppl 4, 78-86. A1 Journal article (refereed), original research -
Commonalities in epileptogenic processes from different acute brain insults: Do they translate?
Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks-Kayal AR, Engel J Jr, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D et al., 2017, Epilepsia, 2018; 59, 1, 37-66. A2 Review article, Literature review, Systematic review -
Decreased levels of active uPA and KLK8 assessed by [111In]MICA-401 binding correlate with the seizure burden in an animal model of temporal lobe epilepsy
Missault S, Peeters L, Amhaoul H, Thomae D, Van Eetveldt A, Favier B, Thakur A, Van Soom J, Pitkänen A, Augustyns K, Joossens J, Staelens S, Dedeurwaerdere S, 2017, Epilepsia, 58, 9, 1615-1625. A1 Journal article (refereed), original research -
Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy
Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatilloa O, Sallinen J, Ndode-Ekanea XE, Pitkänen A, 2017, Epilepsy research, 136, 18-34. A1 Journal article (refereed), original research -
Epilepsy After Traumatic Brain Injury
Pitkänen Asla, Kyyriäinen Jenni, Andrade Pedro, Pasanen Lotta, Ndode-Ekane Xavier Ekolle, 2017, Pitkänen Asla, Buckmaster Paul S, Galanopoulou Aristea S, Moshé Solomon L, Models of Seizures and Epilepsy (Second Edition), 661-681. A3 Book section, Chapters in research books -
Epilepsy in Models of Alzheimer's Disease
Tanila H, Pitkänen A, 2017, Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL, Models of Seizures and Epilepsy (Second Edition), 1021-1030. A3 Book section, Chapters in research books -
Generalized Seizures after Experimental Traumatic Brain Injury Occur at the Transition from Slow-Wave to Rapid-Eye-Movement Sleep
Andrade Pedro, Nissinen Jari, Pitkanen Asla, 2017, Journal of neurotrauma, 34, 7, 1482-1487. A1 Journal article (refereed), original research -
Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy
Srivastava, Prashant K; Roncon, Paolo; Lukasiuk, Katarzyna; Gorter, Jan A; Aronica, Eleonora; Pitkänen, Asla; Petretto, Enrico; Johnson, Michael R; Simonato, Michele, 2017, eNeuro, 4, 6, 1-22. A1 Journal article (refereed), original research -
Models of Seizures and Epilepsy (Second Edition)
Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL, 2017, Elsevier. C2 Edited book, conference proceedings or special issue of a journal -
Standardization procedure for plasma biomarker analysis in rat models of epileptogenesis: Focus on circulating microRNAs
van Vliet Erwin A, Puhakka Noora, Mills James D, Srivastava Prashant K, Johnson Michael R, Roncon Paolo, Das Gupta Shalini, Karttunen Jenni, Simonato Michele, Lukasiuk Katarzyna, Gorter Jan A, Aronica Eleonora, Pitkänen Asla, 2017, Epilepsia, 58, 12, 2013-2024. A2 Review article, Literature review, Systematic review -
Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models
Dingledine Raymond, Coulter Douglas A, Fritsch Brita, Gorter Jan A, Lelutiu Nadia, McNamara James, Nadler J Victor, Pitkänen Asla, Rogawski Michael A, Skene Pate, Sloviter Robert S, Wang Yu, Wadman Wytse J, Wasterlain Claude, Roopra Avtar, 2017, Scientific data, 4, -, 1-10. A1 Journal article (refereed), original research -
Unfolded Maps for Quantitative Analysis of Cortical Lesion Location and Extent after Traumatic Brain Injury
Ndode-Ekane Xavier Ekolle, Kharatishvili Irina, Pitkänen Asla, 2017, Journal of neurotrauma, 34, 2, 459-474. A1 Journal article (refereed), original research -
What Can We Model?
Pitkänen A, Galanopoulou AS, Moshé SL, Buckmaster PS, 2017, Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL, Models of Seizures and Epilepsy (Second Edition), 1-3. A3 Book section, Chapters in research books -
What Do Models Model? What Needs to Be Modeled?
Galanopoulou AS, Pitkänen A, Buckmaster PS, Moshé SL, 2017, Pitkänen A, Buckmaster PS, Galanopoulou AS, Moshé SL, Models of Seizures and Epilepsy (Second Edition), 1107-1119. A3 Book section, Chapters in research books -
Advances in the development of biomarkers for epilepsy
Pitkänen A, Löscher W, Vezzani A, Becker AJ, Simonato M, Lukasiuk K, Gröhn O, Bankstahl JP, Friedman A, Aronica E, Gorter JA, Ravizza T, Sisodiya SM, Kokaia M, Beck H, 2016, The Lancet Neurology, 15, 8, 843-856. A2 Review article, Literature review, Systematic review -
Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44, and S100a4 as Treatment Targets
Lipponen Anssi, Paananen Jussi, Puhakka Noora, Pitkänen Asla, 2016, Scientific reports, 6, 31570. A1 Journal article (refereed), original research -
Common data elements and data management: Remedy to cure underpowered preclinical studies
Lapinlampi N, Melin E, Aronica E, Bankstahl JP, Becker A, Bernard C, Gorter JA, Gröhn O, Lipsanen A, Lukasiuk K, Löscher W, Paananen J, Ravizza T, Roncon P, Simonato M, Vezzani A, Kokaia M, Pitkänen A, 2016, Epilepsy research, 129, January 2017, 87-90. A1 Journal article (refereed), original research -
Dynamics of PDGFRß Expression in Different Cell Types After Brain Injury
Kyyriäinen Jenni, Ndode-Ekane Xavier Ekkolle, Pitkänen Asla, 2016, Glia, 2017; 65, 2 (February 2017), 322-341. A1 Journal article (refereed), original research -
Epileptogenesis after traumatic brain injury in Plaur-deficient mice
Bolkvadze T, Puhakka N, Pitkänen A, 2016, Epilepsy & behavior, 60, July 2016, 187-196. A1 Journal article (refereed), original research -
Etiology matters - Genomic DNA methylation patterns in three rat models of acquired epilepsy
Debski KJ, Pitkanen A, Puhakka N, Bot AM, Khurana I, Harikrishnan KN, Ziemann M, Kaspi A, El-Osta A, Lukasiuk K, Kobow K, 2016, Scientific reports, 6, 25668. A1 Journal article (refereed), original research -
Ex Vivo Tracing of NMDA and GABA-A Receptors in Rat Brain After Traumatic Brain Injury Using 18F-GE-179 and 18F-GE-194 Autoradiography
López-Picón F, Snellman A, Shatillo O, Lehtiniemi P, Grönroos TJ, Marjamäki P, Trigg W, Jones PA, Solin O, Pitkänen A, Haaparanta-Solin M, 2016, Journal of nuclear medicine, 57, 9, 1442-1447. A1 Journal article (refereed), original research -
Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents
Pirttimäki T, Salo RA, Shatillo A, Kettunen MI, Paasonen J, Sierra A, Jokivarsi K, Leinonen V, Andrade P, Quittek S, Pitkänen A, Gröhn O, 2016, Journal of neuroscience methods, 274, 154-163. A1 Journal article (refereed), original research -
Increased Epileptiform EEG Activity and Decreased Seizure Threshold in Arctic APP Transgenic Mouse Model of Alzheimer's Disease
Ziyatdinova Sofya, Rönnbäck Annica, Gurevicius Kestutis, Miszczuk Diana, Graff Caroline, Winblad Bengt, Pitkänen Asla, Tanila Heikki, 2016, Current alzheimer research, 13, 7, 817-830. A1 Journal article (refereed), original research -
WONOEP appraisal: Imaging biomarkers in epilepsy
van Vliet EA, Dedeurwaerdere S, Cole AJ, Friedman A, Koepp MJ, Potschka H, Immonen R, Pitkänen A, Federico P, 2016, Epilepsia, 58, 3, 315-330. A2 Review article, Literature review, Systematic review -
Development of epilepsy after ischaemic stroke
Pitkänen Asla, Roivainen Reina, Luasiuk Katarzyna, 2015, The Lancet Neurology, 2016; 15, 2, 185-197. A2 Review article, Literature review, Systematic review -
Diffusion tensor imaging detects chronic microstructural changes in white and gray matter after traumatic brain injury in rat
Laitinen Teemu, Sierra Alejandra, Bolkvadze Tamuna, Pitkänen Asla, Gröhn Olli, 2015, Frontiers in neuroscience, 9, Article 128, 12 p. A1 Journal article (refereed), original research -
Epilepsy biomarkers
Engel Jerome Jr, Pitkänen Asla, 2015, Shorvon Simon D, Perucca Emilio, Engel Jerome Jr. (Eds.), Treatment of Epilepsy (4th Edition), 103-109. A3 Book section, Chapters in research books -
Epilepsy priorities in Europe: A report of the ILAE-IBE Epilepsy Advocacy Europe Task Force
Baulac Michel, de Boer Hanneke, Elger Christian, Glynn Mike, Kälviäinen Reetta, Little Ann, Mifsud Janet, Perucca Emilio, Pitkänen Asla, Ryvlin Philippe, 2015, Epilepsia, [epub ahead of print 28 SEP 2015]. A1 Journal article (refereed), original research -
Epileptogenesis
Pitkänen Asla, Lukasiuk Katarzyna, Dudek F Edward, Staley Kevin J, 2015, Cold Spring Harbor perspectives in medicine, [epub ahead of print Sep 18, 2015], a022822. A1 Journal article (refereed), original research -
Epileptogenesis after traumatic brain injury in Plau-deficient mice
Bolkvadze Tamuna, Rantala Jukka, Puhakka Noora, Andrade Petro, Pitkänen Asla, 2015, Epilepsy & behavior, 51, 19-27. A1 Journal article (refereed), original research -
Expression of PDGFR-beta positive NG2 cells in the hippocampus after status epilepticus
Kyyriäinen J., Ndode-Ekane X. E., Pitkänen A., 2015, Glia. -
Imaging microstructural damage and plasticity in the hippocampus during epileptogenesis
Sierra A, Gröhn O, Pitkänen A, 2015, Neuroscience, 309, 162-172. A2 Review article, Literature review, Systematic review -
Opportunities for improving animal welfare in rodent models of epilepsy and seizures
Lidster K, Jefferys JG, Blümcke I, Crunelli V, Flecknell P, Frenguelli BG, Gray WP, Kaminski R, Pitkänen A, Ragan I, Shah M, Simonato M, Trevelyan A, Volk H, Walker M, Yates N, Prescott MJ, 2015, Journal of neuroscience methods, 2016; 260, 2-25. A1 Journal article (refereed), original research -
Reduction of epileptiform activity by valproic acid in a mouse model of Alzheimer's disease is not long-lasting after treatment discontinuation
Ziyatdinova Sofya, Viswanathan Jayashree, Hiltunen Mikko, Tanila Heikki, Pitkänen Asla, 2015, Epilepsy research, 112, 43-55. A1 Journal article (refereed), original research -
Traumatic Brain Injury Increases the Expression of Nos1, Aß Clearance, and Epileptogenesis in APP/PS1 Mouse Model of Alzheimer's Disease
Miszczuk Diana, Debski Konrad J, Tanila Heikki, Lukasiuk Katarzyna, Pitkänen Asla, 2015, Molecular neurobiology, 2016; 53, 10, 7010-7027. A1 Journal article (refereed), original research -
Urokinase-type plasminogen activator deficiency has little effect on seizure susceptibility and acquired epilepsy phenotype but reduces spontaneous exploration in mice
Rantala J, Kemppainen S, Ndode-Ekane XE, Lahtinen V, Bolkvadze Tamuna, Gurevicius K, Tanila H, Pitkänen A, 2015, Epilepsy & behavior, 42, 117-128. A1 Journal article (refereed), original research -
A common SCN1A splice-site polymorphism modifies the effect of carbamazepine on cortical excitability--a pharmacogenetic transcranial magnetic stimulation study
Menzler K, Hermsen A, Balkenhol K, Duddek C, Bugiel H, Bauer S, Schorge S, Reif PS, Klein KM, Haag A, Oertel WH, Hamer HM, Knake S, Trucks H, Sander T, Rosenow F; EPICURE-Consortium, 2014, Epilepsia, 2014 Feb;55(2), 362-9. A1 Journal article (refereed), original research -
Are Alterations in Transmitter Receptor and Ion Channel Expression Responsible for Epilepsies?
Powell Kim L, Lukasiuk Katarzyna, O'Brien Terence J, Pitkänen Asla, 2014, Helen E. Scharfman, Paul S. Buckmaster, Issues in Clinical Epileptology: A View from the Bench, 211-29. A3 Book section, Chapters in research books -
Brain Extracellular Matrix in Health and Disease
Dityatev A, Wehrle-Haller B, Pitkänen A, 2014, Elsevier. C1 Book -
Decreased resting functional connectivity after traumatic brain injury in the rat
Mishra Asht Mangal, Bai Xiaoxiao, Sanganahalli Basavaraju G, Waxman Stephen G, Shatillo Olena, Gröhn Olli, Hyder Fahmeed, Pitkänen Asla, Blumenfeld Hal, 2014, PLoS ONE, 2014 Apr 18;9(4), e95280. A1 Journal article (refereed), original research -
Effect of lacosamide on structural damage and functional recovery after traumatic brain injury in rats
Pitkänen A, Immonen R, Ndode-Ekane X, Gröhn O, Stöhr T, Nissinen J, 2014, Epilepsy research, 2014 May;108(4), 653-65. A1 Journal article (refereed), original research -
Epilepsy related to traumatic brain injury
Pitkänen Asla, Immonen Riitta, 2014, Neurotherapeutics, 11, 2, 286-296. A2 Review article, Literature review, Systematic review -
Expression of GABA receptor subunits in the hippocampus and thalamus after experimental traumatic brain injury
Drexel M, Puhakka N, Kirchmair E, Hörtnagl H, Pitkänen A, Sperk G, 2014, Neuropharmacology, 2014 Sep 16, pii: S0028-3908(14)00306-2. A1 Journal article (refereed), original research -
Gender issues in antiepileptogenic treatments
Pitkänen A, Huusko N, Ndode-Ekane XE, Kyyriäinen J, Lipponen A, Lipsanen A, Sierra A, Bolkvadze T, 2014, Neurobiology of disease, 2014 Jun 6 ePub ahead of print, pii: S0969-9961(14)00163-6. A1 Journal article (refereed), original research -
In response to commentary on cavernoma-related epilepsy: review and recommendations for management-report of the surgical task force of the ILAE commission on therapeutic strategies
Rosenow F, Alonso-Vanegas MA, Baumgartner C, Blümcke I, Carreño M, Gizewski ER, Hamer HM, Knake S, Kahane P, Lüders HO, Mathern GW, Menzler K, Miller J, Otsuki T, Ozkara C, Pitkänen A, Roper SN, Sakamoto AC, Sure U, Walker MC, Steinhoff BJ; Surgical Task Force, Commission on Therapeutic Strategies of the ILAE, 2014, Epilepsia, 55, 3, 466-467. A1 Journal article (refereed), original research -
Neural ECM and epilepsy
Pitkänen A, Ndode-Ekane XE, Lukasiuk K, Wilczynski GM, Dityatev A, Walker MC, Chabrol E, Dedeurwaerdere S, Vazquez N, Powell EM, 2014, Progress in brain research, 214, 229-62. A1 Journal article (refereed), original research -
Parvalbumin immunoreactivity and expression of GABAA receptor subunits in the thalamus after experimental TBI
Huusko N, Pitkänen A, 2014, Neuroscience, 2014 May 16;267, 30-45.. A1 Journal article (refereed), original research -
Past and Present Definitions of Epileptogenesis and Its Biomarkers
Pitkänen A, Engel J Jr, 2014, Neurotherapeutics, 2014 Apr;11(2), 231-41. A2 Review article, Literature review, Systematic review -
Posttraumatic epilepsy - Disease or comorbidity?
Pitkänen Asla, Kemppainen Samuli, Ndode-Ekane Xavier Ekolle, Huusko Noora, Huttunen Joanna K, Gröhn Olli, Immonen Riikka, Sierra Alejandra, Bolkvadze Tamuna, 2014, Epilepsy & behavior, 2014 Feb 11., [Epub ahead of print]. A2 Review article, Literature review, Systematic review -
The challenge and promise of anti-epileptic therapy development in animal models
Simonato Michele, Brooks-Kayal Amy R, Engel Jr Jerome, Galanopoulou Aristea S, Jensen Frances E, Moshé Solomon L, O'Brien Terence J, Pitkanen Asla, Wilcox Karen S, French Jacqueline A, 2014, The Lancet Neurology, 13, 9, 949-60. A1 Journal article (refereed), original research -
Cavernoma-related epilepsy: Review and recommendations for management-Report of the Surgical Task Force of the ILAE Commission on Therapeutic Strategies
Rosenow F, Alonso-Vanegas MA, Baumgartner C, Blümcke I, Carreño M, Gizewski ER, Hamer HM, Knake S, Kahane P, Lüders HO, Mathern GW, Menzler K, Miller J, Otsuki T, Ozkara C, Pitkänen A, Roper SN, Sakamoto AC, Sure U, Walker MC, Steinhoff BJ; Surgical Task Force, Commission on Therapeutic Strategies of the ILAE, 2013, Epilepsia, 2013 Dec;54(12):, 2025-35.. A1 Journal article (refereed), original research -
Diffusion tensor imaging of hippocampal network plasticity
Sierra A, Laitinen T, Gröhn O, Pitkänen A, 2013, Brain structure and function, 220, 2, 781-801. A1 Journal article (refereed), original research -
Epilepsy biomarkers
Engel J Jr, Pitkänen A, Loeb JA, Dudek FE, Bertram EH 3rd, Cole AJ, Moshé SL, Wiebe S, Jensen FE, Mody I, Nehlig A, Vezzani A, 2013, Epilepsia, 2013 Aug;54 Suppl 4, 61-69. A1 Journal article (refereed), original research -
Epilepsy on the horizon
Epilepsy Advocacy Europe, Sheanon E, Pitkänen A, 2013, Epilepsia, 54, 1713-4. A1 Journal article (refereed), original research -
Epilepsy therapy development: Technical and methodologic issues in studies with animal models
Galanopoulou AS, Kokaia M, Loeb JA, Nehlig A, Pitkänen A, Rogawski MA, Staley KJ, Whittemore VH, Edward Dudek F, 2013, Epilepsia, 2013 Aug;54 Suppl 4, 13-23. A1 Journal article (refereed), original research -
Issues related to development of antiepileptogenic therapies
Pitkänen A, Nehlig A, Brooks-Kayal AR, Dudek FE, Friedman D, Galanopoulou AS, Jensen FE, Kaminski RM, Kapur J, Klitgaard H, Löscher W, Mody I, Schmidt D, 2013, Epilepsia, 2013 Aug;54 Suppl 4:, 35-43. A1 Journal article (refereed), original research -
Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy
Huusko N, Römer C, Ndode-Ekane XE, Lukasiuk K, Pitkänen A, 2013, Brain structure and function, 2015; 220, 1, 153-191. A1 Journal article (refereed), original research -
MRI biomarkers for post-traumatic epileptogenesis.
Immonen R, Kharatishvili I, Gröhn O, Pitkänen A, 2013, Journal of neurotrauma, 2013 Jul 15;30(14), 1305-9. A1 Journal article (refereed), original research -
Monitoring functional impairment and recovery after traumatic brain injury in rats by FMRI
Niskanen JP, Airaksinen AM, Sierra A, Huttunen JK, Nissinen J, Karjalainen PA, Pitkänen A, Gröhn OH, 2013, Journal of neurotrauma, 2013 Apr 1;30(7), 546-56. A1 Journal article (refereed), original research -
Targets for antiepileptogenesis: Overview
Pitkänen Asla, 2013, Potschka H and Lerche H (eds.), Therapeutic targets and perspectives in the pharmacological treatment of epilepsy, 86-90. A3 Book section, Chapters in research books -
Detection of Calcifications In Vivo and Ex Vivo after Brain Injury in Rat Using SWIFT
Lehto LJ, Sierra A, Corum CA, Zhang J, Idiyatullin D, Pitkänen A, Garwood M, Gröhn O, 2012, Neuroimage, 2012 Jul 16;61(4), 761-72. A1 Journal article (refereed), original research -
Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease
Zilberter M, Ivanov A, Ziyatdinova S, Mukhtarov M, Malkov A, Alpár A, Tortoriello G, Botting CH, Fülöp L, Osypov AA, Pitkänen A, Tanila H, Harkany T, Zilberter Y, 2012, Journal of neurochemistry, 2012 Dec 14.[Epub ahead of print]. A1 Journal article (refereed), original research -
Finding a better drug for epilepsy: Antiepileptogenesis targets
Kobow K, Auvin S, Jensen F, Löscher W, Mody I, Potschka H, Prince D, Sierra A, Simonato M, Pitkänen A, Nehlig A, Rho JM, 2012, Epilepsia, 2012 Nov;53(11), 1868-1876. A2 Review article, Literature review, Systematic review -
Head Trauma and Epilepsy
Pitkänen Asla, Bolkvadze Tamuna, 2012, Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition, 331-342. A3 Book section, Chapters in research books -
Identification of new epilepsy treatments: issues in preclinical methodology
Galanopoulou AS, Buckmaster PS, Staley KJ, Moshé SL, Perucca E, Engel J Jr, Löscher W, Noebels JL, Pitkänen A, Stables J, White HS, O'Brien TJ, Simonato M, 2012, Epilepsia, 2012 Mar;53(3), 571-82. A1 Journal article (refereed), original research -
Molecular Basis of Acquired Epileptogenesis
Lukasiuk K, Pitkänen A, 2012, Stefan H, Theodore W, Handbook of clinical neurology: Epilepsy Part I: Basic Principles and Diagnosis, 3-12. A3 Book section, Chapters in research books -
New Insight on the Mechanisms of Epileptogenesis in the Developing Brain
Kubova H, Lukasiuk K, Pitkänen A, 2012, Akalan Nejat, Di Rocco Concezio, Pediatric Epilepsy Surgery. A3 Book section, Chapters in research books -
Simultaneous BOLD fMRI and local field potential measurements during kainic acid-induced seizures
Airaksinen AM, Hekmatyar SK, Jerome N, Niskanen JP, Huttunen JK, Pitkänen A, Kauppinen RA, Gröhn OH, 2012, Epilepsia, 2012 Jul;53(7), 1245-53. A1 Journal article (refereed), original research -
The Written Declaration on Epilepsy: An important achievement for Europe and beyond
Baulac M, De Boer H, Elger C, Glynn M, Kälviäinen R, Little A, Mifsud J, Perucca E, Pitkänen A, 2012, Seizure: european journal of epilepsy, 21, 75-76. A2 Review article, Literature review, Systematic review -
Urokinase-Type Plasminogen Activator Receptor Modulates Epileptogenesis in Mouse Model of Temporal Lobe Epilepsy
Ndode-Ekane XE, Pitkänen A, 2012, Molecular neurobiology, 2012 Dec 21. [Epub ahead of print]. A1 Journal article (refereed), original research -
Anti-epileptogenesis in rodent post-traumatic epilepsy models
Pitkänen Asla, Bolkvadze Tamuna, Immonen Riikka, 2011, Neuroscience letters, 497, 163-171. A2 Review article, Literature review, Systematic review -
Diffusion tensor MRI with tract-based spatial statistics and histology reveals undiscovered lesioned areas in kainate model of epilepsy in rat
Sierra Alejandra, Laitinen Teemu, Lehtimäki Kimmo, Rieppo Lassi, Pitkänen Asla, Gröhn Olli, 2011, Brain structure and function, 216, 123-135. A1 Journal article (refereed), original research -
Magnetic resonance imaging of regional hemodynamic and cerebrovascular recovery after lateral fluid-percussion brain injury in rats
Hayward Nick Mark Edward Alexander, Tuunanen Pasi, Immonen Riikka, Ndode-Ekane Xavier Ekolle, Pitkänen Asla, Gröhn Olli, 2011, Journal of cerebral blood flow and metabolism, 31, 166-177. A1 Journal article (refereed), original research -
Mechanisms of epileptogenesis and potential treatment targets
Pitkänen Asla, Lukasiuk Katarzyna, 2011, The Lancet Neurology, 10, 173-186. A2 Review article, Literature review, Systematic review -
Molecular biomarkers of epileptogenesis
Pitkänen A, Lukasiuk K, 2011, Biomarkers in medicine, 5, 5, 629-33. A1 Journal article (refereed), original research -
Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain
Gröhn O, Sierra A, Immonen R, Laitinen T, Lehtimäki K, Airaksinen A, Hayward N, Nairismagi J, Lehto L, Pitkänen A, 2011, Epilepsia, 52(Suppl. 8), 57-60. B1 Non-refereed journal articles -
Progressive loss of phasic, but not tonic, GABAA receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats
Pavlov I,Huusko N,Drexel M,Kirchmair E,Sperk G,Pitkänen A,Walker MC, 2011, Neuroscience, 194, 208-219. A1 Journal article (refereed), original research -
Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels
Ziyatdinova Sofya, Gurevicius Kestutis, Kutchiashvili Nino, Bolkvadze Tamuna, Nissinen Jari, Tanila Heikki, Pitkänen Asla, 2011, Epilepsy research, 94, 75-85. A1 Journal article (refereed), original research -
Association of the severity of cortical damage with the occurrence of spontaneous seizures and hyperexcitability in an animal model of posttraumatic epilepsy
Kharatishvili I & Pitkänen A, 2010, Epilepsy research, 90, 47-59. A1 Journal article (refereed), original research -
Diffusion tensor MRI of axonal plasticity in the rat hippocampus
Laitinen T, Sierra A, Pitkänen A & Gröhn O, 2010, Neuroimage, 51, 251-530. A1 Journal article (refereed), original research -
Posttraumatic epilepsy
Kharatishvili I & Pitkänen A, 2010, Current opinion in neurology, 23, 2, 183-188. A1 Journal article (refereed), original research -
Urokinase-type plasminogen activator regulates neurodegeneration and neurogenesis but not vascular changes in the mouse hippocampus after status epilepticus
Lahtinen L, Ndode-Ekane XE, Barinka F, Akamine Y, Esmaeili MH, Rantala J & Pitkänen A, 2010, Neurobiology of disease, 37, 692-703. A1 Journal article (refereed), original research -
Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy
Ndode-Ekane XE, Hayward N, Gröhn O & Pitkänen A, 2010, Neuroscience, 166, 312-332. A1 Journal article (refereed), original research -
Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy
Minkeviciene R, Rheims S, Dobszay MB, Zilberter M, Hartikainen J, Fülöp L, Penke B, Zilberter Y, Harkany T, Pitkänen A, Tanila H, 2009, Journal of neuroscience, 29, 11, 3453-3462. A1 Journal article (refereed), original research -
Commentary: the prospect of cell-based therapy for epilepsy
Kriegstein AR, Pitkänen A, 2009, Neurotherapeutics, 6, 295-299. A2 Review article, Literature review, Systematic review -
Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat - 11 months follow-up
Immonen RJ, Kharatishvili I, Niskanen J-P, Gröhn H, Pitkänen A, Gröhn OHJ, 2009, Experimental neurology, 215, 29-40. A1 Journal article (refereed), original research -
Epilepsy: Neuronal Death
Pitkänen A, Lukasiuk K, 2009, Squire LR, Enclyclopedia of Neuroscience. Vol. 3, 1159-1166. A3 Book section, Chapters in research books -
Epileptogenesis alters gene expression pattern in rats subjected to amygdala-dependent emotional learning
Majak K, Dabrowski M, Pitkänen A, 2009, Neuroscience, 159, 468-482. A1 Journal article (refereed), original research -
Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus
Lahtinen L, Huusko N, Myöhänen H, Lehtivarjo AK, Pellinen R, Turunen MP, Ylä-Herttuala S, Pirinen E, Pitkänen A, 2009, Neuroscience, 163, 316-328. A1 Journal article (refereed), original research -
From traumatic brain injury to posttraumatic epilepsy: what animal models tell us about the process and treatment options
Pitkänen A, Immonen RJ, Gröhn OH, Kharatishvili I, 2009, EPILEPSIA. SUPPLEMENT, 50, 2, 21-29. A2 Review article, Literature review, Systematic review -
Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice
Marklund N, Morales D, Clausen F, Hånell A, Kiwanuka O, Pitkänen A, Gimbel DA, Philipson O, Lannfelt L, Hillered L, Strittmatter SM, McIntosh TK, 2009, Neuroscience, 163, 540-551. A1 Journal article (refereed), original research -
Genes relevant to epileptogenic mechanisms
Maja K, Pitkänen A, 2009, Avanzini G, Noebels J, Genetics of Epilepsy and Genetic Epilepsies, 31-38. A3 Book section, Chapters in research books -
Molecular and cellular basis of epileptogenesis in symptomatic epilepsy
Pitkänen A, Lukasiuk K, 2009, Epilepsy & behavior, 14, 16-25. A1 Journal article (refereed), original research -
Neuropeptide Y overexpression using recombinant adeno-associated viral vectors
Noé F, Frasca A, Balducci C, Carli M, Sperk G, Ferraguti F, Pitkänen A, Bland R, Fitzsimons H, During M, Vezzani A, 2009, Neurotherapeutics, 6, 300-306. A1 Journal article (refereed), original research -
Posttraumatic models
Kharatishvili I, Pitkänen A, 2009, Schwartzkroin PA, Encyclopedia of Basic Epilepsy Research. Vol. 3, 1229-1238. A3 Book section, Chapters in research books -
Quantitative MRI predicts long-term structural and functional outcome after experimental traumatic brain injury
Immonen RJ, Kharatishvili I, Gröhn H, Pitkänen A, Gröhn OHJ, 2009, Neuroimage, 45, 1-9. A1 Journal article (refereed), original research -
Quantitative T2 mapping as a potential marker for the initial assessment of the severity of damage after traumatic brain injury in rat
Kharatishvili I, Sierra A, Immonen RJ, Gröhn OHJ, Pitkänen A, 2009, Experimental neurology, 217, 154-164. A1 Journal article (refereed), original research -
Seizure-induced gene expression
Pitkänen A, Lukasiuk K, 2009, Schwartzkroin PA, Encyclopedia of Basic Epilepsy Research, 1302-1309. A3 Book section, Chapters in research books -
Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus
Immonen RJ, Kharatishvili I, Sierra A, Einula C, Pitkänen A, Gröhn OH, 2008, Neuroimage, 40, 1718-1730. A1 Journal article (refereed), original research -
Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy
Noè F, Pool AH, Nissinen J, Gobbi M, Bland R, Rizzi M, Balducci C, Ferraguti F, Sperk G, During MJ, Pitkänen A, Vezzani A, 2008, Brain, 131, 6, 1506-1515. A1 Journal article (refereed), original research -
Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat
Goffin K, Nissinen J, Van Laere K, Pitkänen A, 2007, Experimental neurology, 205, 501-505. A1 Journal article (refereed), original research -
Diazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocamus-depend learning
Siiskonen H, Oikari S, Korhonen V-P, Pitkänen A, Voikar V, Kettunen M, Hakumäki J, Wahlfors T, Pussinen R, Penttonen M, Kiehne K, Kaasinen SK, Alhonen L, Jänne J, Herzig K-H, 2007, Molecular and cellular neuroscience, 34, 2, 199-208. A1 Journal article (refereed), original research -
Effect of antiepileptic drugs on spontaneous seizures in epileptic rats
Nissinen J, Pitkänen A, 2007, Epilepsy research, 73, 2, 181-191. A1 Journal article (refereed), original research -
Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat
Pitkänen A, Mathiesen C, Rønn LCB, Møller A, Nissinen J, 2007, Epilepsy research, 74, 1, 45-54. A1 Journal article (refereed), original research -
Epileptogenesis after cortical photothrombotic brain lesion in rats
Karhunen H, Bezvenyuk Z, Nissinen J, Sivenius J, Jolkkonen J, Pitkänen A, Sivenius J, 2007, Neuroscience, 148, 1, 314-324. A1 Journal article (refereed), original research -
Epileptogenesis in experimental models
Pitkänen A, Kharatisvili I, Karhunen H, Lukasiuk K, Immonen R, Nairismägi J, Gröhn O, Nissinen J, 2007, EPILEPSIA. SUPPLEMENT, 48, 2, 13-20. A1 Journal article (refereed), original research -
Gene therapy in epilepsy: The focus on NPY
Noe' F, Nissinen J, Pitkänen A, Gobbi M, Sperk G, During M, Vezzani A, 2007, Peptides, 28, 2, 377-383. A2 Review article, Literature review, Systematic review -
Genetics of epilepsy: epilepsy research foundation workshop report
Sisodiya S, Cross JH, Blümcke I, Chadwick D, Craig J, Crino PB, Debenham P, Delanty N, Elmslie F, Gardiner M, Golden J, Goldstein D, Greenberg DA, Guerrini R, Hanna M, Harris J, Harrison P, Johnson MR, Kirov G, Kullman DM, Makoff A, Marini C, 2007, Epileptic disorders, 9, 2, 194-236. A1 Journal article (refereed), original research -
Increased expression of caspase 2 in experimental and human temporal lobe epilepsy
Narkilahti S, Jutila L, Alafuzoff I, Karkola K, Paljärvi L, Immonen A, Vapalahti M, Mervaala E, Kälviäinen R, Pitkänen A, 2007, Neuromolecular medicine, 9, 2, 129-144. A1 Journal article (refereed), original research -
Magnetic resonance imaging in animal models of epilepsy-noninvasive detection of structural alterations
Gröhn O, Pitkänen A, 2007, EPILEPSIA. SUPPLEMENT, 48, 4, 3-10. A1 Journal article (refereed), original research -
Mechanisms of emotional learning in normal and epileptic brain
Majak K, Pitkänen A, 2007, Natsume K, Hanazawa A, Miki T, Brain-Inspired IT III, 22-27. A4 Conference proceedings -
Neuroprotection with anti-epileptic drugs: state of the evidence
Pitkänen A, 2007, Trimble MR, Seizure Freedom: Clinical, Research and Quality of Life Perspectives, 9-27. A3 Book section, Chapters in research books -
Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis
Kharatishvili I, Immonen R, Gröhn O, Pitkänen A, 2007, Brain, 130, 12, 3155-3168. A1 Journal article (refereed), original research -
The novel antiepileptic agent RWJ-333369-A, but not its analog RWJ-333369, reduces regional cerebral edema without affecting neurobehavioral outcome or cell death following experimental traumatic brain injury
Keck CA, Thompson HJ, Pitkänen A, LeBold DG, Morales DM, Plevy JB, Puri R, Zhao B, Dichter M, McIntosh TK, 2007, Restorative neurology and neuroscience, 25, 2, 77-90. A1 Journal article (refereed), original research -
A long-term video-EEG and behavioral follow-up after endothelin-1 induced middle cerebral artery occlusion in rats
Karhunen H, Nissinen J, Sivenius J, Jolkkonen J, Pitkänen A, 2006, Epilepsy research, 72, 25-38. A1 Journal article (refereed), original research -
A model of posttraumatic epilepsy induced by lateral fluid-percussion brain injury in rats
Kharatishvili I, Nissinen JP, McIntosh TK, Pitkänen A, 2006, Neuroscience, 140, 685-697. A1 Journal article (refereed), original research -
Animal models of post-traumatic epilepsy
Pitkänen A, Mcintosh TK, 2006, Journal of neurotrauma, 23, 2, 241-261. A1 Journal article (refereed), original research -
Change over of the baton
Pitkänen A, Gilliam F, 2006, Epilepsy research. -
Chapter 11 Epileptogenesis-related genes revisited
Lukasiuk K, Dabrowski M, Adach A, Pitkänen A, 2006, Progress in brain research, 158, 223-241. A1 Journal article (refereed), original research -
Cystatin C expression is increased in the hippocampus following photothrombotic stroke in rat
Pirttilä TJ, Pitkänen A, 2006, Neuroscience letters, 395, 2, 108-113. A1 Journal article (refereed), original research -
Fear conditioning is impaired in systemic kainic acid and amygdala-stimulation models of epilepsy
Kemppainen EJS, Nissinen J, Pitkänen A, 2006, Epilepsia, 47, 5, 820-829. A1 Journal article (refereed), original research -
Increased expression and activity of urokinase-type plasminogen activator during epileptogenesis
Lahtinen L, Lukasiuk K, Pitkänen A, 2006, European journal of neuroscience, 24, 7, 1935-1945. A1 Journal article (refereed), original research -
Manganese-enhanced magnetic resonance imaging of mossy fiber plasticity in vivo
Nairismägi J, Pitkänen A, Narkilahti S, Huttunen J, Kauppinen RA, Gröhn OHJ, 2006, Neuroimage, 30, 1, 130-135. A1 Journal article (refereed), original research -
New data suggest that discontinuation of status epilepticus is not necessary for antiepileptogenic effect in immature brain
Pitkänen A, 2006, Epilepsy currents. -
Status epilepticus in 12-day-old rats leads to temporal lobe neurodegeneration and volume reduction: A histologic and MRI study
Nairismägi J, Pitkänen A, Kettunen MI, Kauppinen RA, Kubova H, 2006, Epilepsia, 47, 3, 479-488. A1 Journal article (refereed), original research -
Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat
Pitkänen A, Kharatishvili I, Narkilahti S, Lukasiuk K, Nissinen J, 2005, Epilepsy research, 63, 27-42. A1 Journal article (refereed), original research -
Caspase 6 expression in the rat hippocampus during epileptogenesis and epilepsy
Narkilahti S, Pitkänen A, 2005, Neuroscience, 131, 4, 887-897. A1 Journal article (refereed), original research -
Cystatin C expression is associated with granule cell dispersion in epilepsy
Pirttilä TJ, Manninen A, Jutila L, Nissinen J, Kälviäinen R, Vapalahti M, Immonen A, Paljärvi L, Karkola K, Alafuzoff I, Mervaala E, Pitkänen A, 2005, Annals of neurology, 58, 2, 211-223. A1 Journal article (refereed), original research -
Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse
Pirttilä TJ, Lukasiuk K, Håkansson K, Grubb A, Abrahamson M, Pitkänen A, 2005, Neurobiology of disease, 20, 241-253. A1 Journal article (refereed), original research -
Epileptic seizure detection: A nonlinear viewpooint
Päivinen N, Lammi S, Pitkänen A, Nissinen J, Penttonen M, Grönfors T, 2005, Computer methods and programs in biomedicine, 79, 2, 151-159. A1 Journal article (refereed), original research -
Epileptogenesis after experimental focal cerebral ischemia
Karhunen H, Jolkkonen J, Sivenius J, Pitkänen A, 2005, Neurochemical research, 30, 12, 1529-1542. A1 Journal article (refereed), original research -
Experimental febrile seizures require an undetermined factor for induction of hippocampal sclerosis in immature rat brain
Pitkänen A, Gröhn O, 2005, Epilepsy currents. -
Experimental models of traumatic brain injury: Do we really need to build a better mousetrap?
Morales DM, Marklund N, Lebold D, Thompson HJ, Pitkanen A, Maxwell WL, Longhi L, Laurer H, Maegele M, Neugebauer E, Graham DI, Stocchetti N, McIntosh TK, 2005, Neuroscience, 136, 4, 971-989. A1 Journal article (refereed), original research -
Hippocampal damage in newly diagnosed focal epilepsy: a prospective MRI study
Salmenperä T, Könönen M, Roberts N, Vanninen R, Pitkänen A, Kälviäinen R, Könönen M, 2005, Neurology, 64, 62-68. A1 Journal article (refereed), original research -
MR volumetric analysis of the piriform cortex and cortical amygdala in drug-refractory temporal lobe epilepsy
Goncalves Pereira PM, Insausti R, Artacho-Pérula E, Salmenperä T, Kälviäinen R, Pitkänen A, 2005, American journal of neuroradiology, 26, 319-332. A1 Journal article (refereed), original research -
Antiepileptic drugs in neuroprotections
Pitkänen A, Kubova H, 2004, Expert opinion on pharmacotherapy, 5, 4, 777-798. A1 Journal article (refereed), original research -
Atipamezole, an alfa2-adrenoceptor antagonist, has disease modifying effects on epileptogenesis in rats
Pitkänen A, Narkilahti S, Bezvenyuk Z, Haapalinna A, Nissinen J, 2004, Epilepsy research, 61, 119-140. A1 Journal article (refereed), original research -
Brain-derived neurotrophic factor signaling modifies hippocampal gene expression during epileptogenesis in transgenic mice
Lähteinen S, Pitkänen A, Knuuttila J, Törönen P, Castrén E, 2004, European journal of neuroscience, 19, 12, 3245-3254. A1 Journal article (refereed), original research -
Damage to the amygdalo-hippocampal projection in temporal lobe epilepsy: A tract-tracing study in chronic epileptic rats
Kemppainen S, Pitkänen A, 2004, Neuroscience, 126, 2, 485-501. A1 Journal article (refereed), original research -
Denervation and reinnervation of amygdaloid neurons in drug-refratory temporal lobe epilepsy
Pitkänen A, 2004, Epilepsy currents. -
Do seizures cause irreversible cognitive damage? Evidence from animal studies
Majak K, Pitkänen A, 2004, EPILEPSY & BEHAVIOR. SUPPLEMENT, 5, S35-S44. A1 Journal article (refereed), original research -
Effect of lamotrigine treatment on epileptogenesis: an experimental study in rat
Nissinen J, Large CH, Stratton SC, Pitkänen A, 2004, Epilepsy research, 58, 2-3, 119-132. A1 Journal article (refereed), original research -
Electrophysiologic changes in the lateral and basal amygdaloid nuclei in temporal lobe epilepsy: an in vitro study in epileptic rats
Niittykoski M, Nissinen J, Penttonen M, Pitkänen A, 2004, Neuroscience, 124, 269-281. A1 Journal article (refereed), original research -
Large-scale analysis of gene expression in epilepsy reseach: is synthesis alreasy possible?
Lukasiuk K, Pitkänen A, 2004, Neurochemical research, 29, 6, 1169-1178. A2 Review article, Literature review, Systematic review -
New pharmacotherapy for epilepsy
Pitkänen A, 2004, Idrugs, 7, 5, 471-477. A2 Review article, Literature review, Systematic review -
Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepy
Nairismägi J, Gröhn OHJ, Kettunen MI, Nissinen J, Kauppinen RA, Pitkänen A, 2004, Epilepsia, 45, 9, 1024-1034. A1 Journal article (refereed), original research -
Projections from the amygdaloid complex to the piriform cortex: A PHA-L study in the rat
Majak K, Rönkkö S, Kemppainen S, Pitkänen A, 2004, Journal of comparative neurology, 476, 414-428. A1 Journal article (refereed), original research -
Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis
Kubová H, Mares P, Suchomelová L, Brozek G, Druga R, Pitkänen A, 2004, European journal of neuroscience, 19, 12, 3255-3265. A1 Journal article (refereed), original research -
Activation of the amygdalo-entorhinal pathway in fear-conditioning in rat
Majak K, Pitkänen A, 2003, European journal of neuroscience, 18, 6, 1652-1659. A1 Journal article (refereed), original research -
Administration of caspase 3 inhibitor during and after status epilepticus in rat: effect on neuronal damage and epileptogenesis
Narkilahti S, Nissinen J, Pitkänen A, 2003, Neuropharmacology, 44, 1068-1088. A1 Journal article (refereed), original research -
American Epilepsy Society - 56th Annual Meeting
Pitkänen A, 2003, Idrugs. -
Assignment of 1H nuclear magnetic resonance visible polyunsaturated fatty acids in BT4C gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death
Griffin JL, Lehtimäki KK, Valonen PK, Gröhn OHJ, Kettunen MI, Ylä-Herttuala S, Pitkänen A, Nicholson JK, Kauppinen RA, 2003, Cancer research, 63, 3195-3201. A1 Journal article (refereed), original research -
Clinical trials in neuroprotection
Pitkänen A, 2003, Idrugs, 6, 3, 200-202. A1 Journal article (refereed), original research -
Do epileptic seizures damage the brain?
Sutula TP, Hagen J, Pitkänen A, 2003, Current opinion in neurology, 16, 2, 189-195. A1 Journal article (refereed), original research -
Exacerbated status epilepticus and acute cell loss, but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signaling
Lähteinen S, Pitkänen A, Koponen E, Saarelainen T, Castrén E, 2003, Neuroscience, 122, 1081-1092. A1 Journal article (refereed), original research -
Expression and activation of caspase 3 following status epilepticus in the rat
Narkilahti S, Pirttilä TJ, Lukasiuk K, Tuunanen J, Pitkänen A, 2003, European journal of neuroscience, 18, 6, 1486-1496. A1 Journal article (refereed), original research -
Intrinsic synaptic circuitry of the amygdala
Pitkänen A, Savander M, Nurminen N, Ylinen A, 2003, Annals of the New York Academy of Sciences, 985, 34-49. A1 Journal article (refereed), original research -
Long-term functional consequences of transient occlusion of the middle cerebral artery in rats: a 1-year follow-up of the development of epileptogenesis and memory impairment in relation to sensorimotor deficits
Karhunen H, Pitkänen A, Virtanen T, Gureviciene I, Pussinen R, Ylinen A, Sivenius J, Nissinen J, Jolkkonen J, 2003, Epilepsy research, 54, 1, 1-10. A1 Journal article (refereed), original research -
Projections from the periamygdaloid cortex to the amygdaloid complex, the hippocampal formation, and the parahippocampal region: A PHA-L study in the rat
Majak K, Pitkänen A, 2003, Hippocampus, 13, 8, 922-942. A1 Journal article (refereed), original research -
Selective changes in gamma-aminobutyric acid type A receptor subunits in the hippocampus in spontaneously seizing rats with chronic temporal lobe epilepsy
Laurén HB, Pitkänen A, Nissinen J, Soini SL, Korpi ER, Holopainen IE, 2003, Neuroscience letters, 349, 58-62. A1 Journal article (refereed), original research -
The Amygdala in Brain Function: Basic and Clinical Approaches
Shinnick-Gallagher P, Pitkänen A, Shekhar A, Cahill L, 2003, New York Academy of Sciences. C2 Edited book, conference proceedings or special issue of a journal -
Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: summary of the NIH/NINDS/AES models II workshop
Stables JP, Bertram E, Dudek FE, Holmes G, Mathern G, Pitkanen A, White HS, 2003, Epilepsia, 44, 12, 1472-1478. A1 Journal article (refereed), original research -
Tunteiden neurobiologiaa
Pitkänen A, 2003, Duodecim, 119, 1471-1478. A1 Journal article (refereed), original research -
cDNA profiling of epileptogenesis in the rat brain
Lukasiuk K, Kontula L, Pitkänen A, 2003, European journal of neuroscience, 17, 2, 271-279. A1 Journal article (refereed), original research -
Comparison of the distribution of calcium-binding proteins and intrinsic connectivity in the lateral nucleus of the rat, monkey, and human amygdala
Pitkänen A, Kemppainen S, 2002, Pharmacology biochemistry and behavior, 71, 3, 369-377. A1 Journal article (refereed), original research -
Decreased BDNF signalling in transgenic mice reduces epileptogenesis
Lähteinen S, Pitkänen A, Saarelainen T, Nissinen J, Koponen E, Castrén E, 2002, European journal of neuroscience, 15, 721-734. A1 Journal article (refereed), original research -
Drug-mediated neuroprotection and anti-epileptogenesis
Pitkänen A, 2002, NEUROLOGY. SUPPLEMENT, 59, 5, S27-S33. A1 Journal article (refereed), original research -
Dynamic changes of status epilepticus-induced neuronal degeneration in the mediodorsal nucleus of the thalamus during postnatal development of the rat
Kubová H, Druga R, Haugvicová R, Suchomelová L, Pitkanen A, 2002, EPILEPSIA. SUPPLEMENT, 43, 5, 54-60. A1 Journal article (refereed), original research -
Efficacy of current antiepileptics to prevent neurodegeneration in epilepsy models
Pitkänen A, 2002, Epilepsy research, 50, 1-2, 141-160. A1 Journal article (refereed), original research -
Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy
Pitkänen A, Sutula TP, 2002, The Lancet Neurology, 1, 3, 173-181. A1 Journal article (refereed), original research -
Neurobiology of epileptogenesis in the temporal lobe
Jutila L, Immonen A, Partanen K, Partanen J, Mervaala E, Ylinen A, Alafuzoff I, Paljärvi L, Karkola K, Vapalahti M, Pitkänen A, 2002, Pickard JD, Dolenc VV, Antunes JL, Reulen H-J, Sindou M, Strong AJ, de Tribolet N, Tulleken CAF, Vapalahti M, Advances and Technical Standards in Neurosurgery, 3-22. A3 Book section, Chapters in research books -
Prevention of epileptogenesis
Pitkänen A, 2002, Levy RH, Mattson RH, Meldrum BS, Perucca E, Antiepileptic Drugs, 169-176. A3 Book section, Chapters in research books -
Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy
Pitkänen A, Nissinen J, Nairismägi J, Lukasiuk K, Gröhn OHJ, Miettinen R, Kauppinen R, 2002, Sutula T, Pitkänen A, Do Seizures Damage the Brain, 67-83. A3 Book section, Chapters in research books -
Projections from the amygdaloid complex to the claustrum and the endopiriform nucleus: a Phaseolus vulgaris leucoagglutinin study in the rat
Majak K, Pikkarainen M, Kemppainen S, Jolkkonen E, Pitkänen A, 2002, Journal of comparative neurology, 451, 3, 236-249. A1 Journal article (refereed), original research -
Projections from the amygdaloid complex to the magnocellular cholinergic basal forebrain in rat
Jolkkonen E, Miettinen R, Pikkarainen M, Pitkänen A, 2002, Neuroscience, 111, 1, 133-149. A1 Journal article (refereed), original research -
Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the entorhinal cortex in the macaque monkey
Pitkanen A, Kelly JL, Amaral DG, 2002, Hippocampus, 12, 2, 186-205. A1 Journal article (refereed), original research -
Projections from the posterior cortical nucleus of the amygdala to the hippocampal formation and parahippocampal region in rat
Kemppainen S, Jolkkonen E, Pitkänen A, 2002, Hippocampus, 12, 6, 735-755. A1 Journal article (refereed), original research -
Upregulation of cystatin C expression in the rat hippocampus during epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy
Lukasiuk K, Pirttilä TJ, Pitkänen A, 2002, EPILEPSIA. SUPPLEMENT, 43, 5, 137-145. A1 Journal article (refereed), original research -
Chronic elevation of brain GABA levels beginning two days after status epilepticus does not prevent epileptogenesis in rats
Halonen T, Nissinen J, Pitkänen A, 2001, Neuropharmacology, 40, 4, 536-550. A1 Journal article (refereed), original research -
Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat
Halonen T, Nissinen J, Pitkanen A, 2001, Epilepsy research, 46, 3, 205-223. A1 Journal article (refereed), original research -
Ex vivo MR microimaging of neuronal damage after kainate-induced status epilepticus in rat: correlation with quantitative histology
Pirttilä T-RM, Pitkänen A, Tuunanen J, Kauppinen RA, 2001, Magnetic resonance in medicine, 46, 5, 946-954. A1 Journal article (refereed), original research -
Hippocampal and amygdaloid damage in partial epilepsy A cross-sectional MRI study of 241 patients
Salmenperä T, Kälviäinen R, Partanen K, Pitkänen A, 2001, Epilepsy research, 46, 69-82. A1 Journal article (refereed), original research -
Interconnectivity between the amygdaloid complex and the amygdalostriatal transition area: a PHA-L study in rat
Jolkkonen E, Pikkarainen M, Kemppainen S, Pitkänen A, 2001, Journal of comparative neurology, 431, 39-58. A1 Journal article (refereed), original research -
Is mossy fiber sprouting present at the time of the first spontaneous seizures in rat experimental temporal lobe epilepsy?
Nissinen J, Lukasiuk K, Pitkänen A, 2001, Hippocampus, 11, 3, 299-310. A1 Journal article (refereed), original research -
MR volumetry of the entorhinal, perirhinal, and temporopolar cortices in drug-refractory temporal lobe epilepsy
Jutila L, Ylinen A, Partanen K, Alafuzoff I, Mervaala E, Partanen J, Vapalahti M, Vainio P, Pitkänen A, 2001, American journal of neuroradiology, 22, 1490-1501. A1 Journal article (refereed), original research -
More evidence for seizure-induced neuron loss: is hippocampal sclerosis both cause and effect of epilepsy?
Sutula TP, Pitkänen A, 2001, Neurology, 57, 169-170. A1 Journal article (refereed), original research -
Neurobiology of epileptogenesis in the temporal lobe
Jutila L, Immonen A, Partanen K, Partanen J, Mervaala E, Ylinen A, Alafuzoff I, Paljärvi L, Karkola K, Vapalahti M, Pitkänen A, 2001, Pickard JD, Dolenc VV, Lobo Antunes J, Reulen H-J, Sindou M, Strong AJ, de Tribolet N, Tulleken CAF, Vapalahti M, Advances and Technical Standards in Neurosurgery, 4-22. A3 Book section, Chapters in research books -
Projections from the amygdalo-piriform transition area to the amygdaloid coplex: A PHA-L study in rat
Jolkkonen E, Miettinen R, Pitkänen A, 2001, Journal of comparative neurology, 432, 440-465. A1 Journal article (refereed), original research -
Projections from the lateral, basal and accessory basal nuclei of the amygdala to the perirhinal and postrhinal cortices in rat
Pikkarainen M, Pitkanen A, 2001, Cerebral cortex, 11, 11, 1064-1082. A1 Journal article (refereed), original research -
Status epilepticus causes necrotic damage in the mediodorsal nucleus of the thalamus in immature rats
Kubová H, Druga R, Lukasiuk K, Suchomelová L, Haugvicová R, Jirmanová I, Pitkänen A, 2001, Journal of neuroscience, 21, 10, 3593-3599. A1 Journal article (refereed), original research -
Time course and mechanisms of amygdaloid damage after kainate-induced status epilepticus in rat
Lukasiuk K, Tuunanen J, Halonen T, Pitkänen A, 2001, Turski L, Schoepp DD, Cavalheiro EA, Excitatory Amino Acids: Ten Years Later, 289-297. A3 Book section, Chapters in research books -
A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat
Nissinen J, Halonen T, Koivisto E, Pitkänen A, 2000, Epilepsy research, 38, 2-3, 177-205. A1 Journal article (refereed), original research -
Anatomic heterogeneity of the rat amygdaloid complex
Pitkänen A, Jolkkonen E, Kemppainen S, 2000, Folia morphologica, 59, 1, 1-23. A2 Review article, Literature review, Systematic review -
Association between the density of mossy fiber sprouting and seizure frequency in experimental and human temporal lobe epilepsy
Pitkänen A, Nissinen J, Lukasiuk K, Jutila L, Paljärvi L, Salmenperä T, Karkola K, Vapalahti M, Ylinen A, 2000, EPILEPSIA. SUPPLEMENT, 41, 6, S24-S29. A1 Journal article (refereed), original research -
Connectivity of the rat amygdaloid complex
Pitkänen A, 2000, Aggleton JP, The Amygdala. A Functional Analysis, 31-115. A3 Book section, Chapters in research books -
Distribution of parvalbumin, calretinin, and calbindin-D28k immunoreactivity in the rat amygdaloid complex and colocalization with gamma-aminobutyric acid
Kemppainen S, Pitkänen A, 2000, Journal of comparative neurology, 426, 441-467. A1 Journal article (refereed), original research -
Do seizures cause neuronal damage in rat amygdala kindling?
Tuunanen J, Pitkänen A, 2000, Epilepsy research, 39, 171-176. A1 Journal article (refereed), original research -
Early detection of irreversible cerebral ischemia in the rat using dispersion of the magnetic resonance imaging relaxation time, T1rho
Gröhn OHJ, Kettunen MI, Mäkelä HI, Penttonen M, Pitkänen A, Lukkarinen JA, Kauppinen RA, 2000, Journal of cerebral blood flow and metabolism, 20, 1457-1466. A1 Journal article (refereed), original research -
GABA(A)-mediated toxicity of hippocampal neurons in vitro
Lukasiuk K, Pitkänen A, 2000, Journal of neurochemistry, 74, 6, 2445-2454. A1 Journal article (refereed), original research -
MRI volumetry of the hippocampus, amygdala, entorhinal cortex, and perirhinal cortex after status epilepticus
Salmenperä T, Kälviäinen R, Partanen K, Mervaala E, Pitkänen A, 2000, Epilepsy research, 40, 155-170. A1 Journal article (refereed), original research -
Morphology of spiny neurons in the human entorhinal cortex: intracellular filling with lucifer yellow
Mikkonen M, Pitkänen A, Soininen H, Alafuzoff I, Miettinen R, 2000, Neuroscience, 96, 3, 515-522. A1 Journal article (refereed), original research -
Projections from the central nucleus of the amygdala to the gastric related area of the dorsal vagal complex: a Phaseolus vulgaris-leucoagglutinin study in rat
Liubashina O, Jolkkonen E, Pitkänen A, 2000, Neuroscience letters, 291, 85-88. A1 Journal article (refereed), original research -
Quantitative MRI volumetry of the entorhinal cortex in temporal lobe epilepsy
Salmenperä T, Kälviäinen R, Partanen K, Pitkänen A, 2000, Seizure: european journal of epilepsy, 9, 208-215. A1 Journal article (refereed), original research -
Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat: a review
Pitkänen A, Pikkarainen M, Nurminen N, Ylinen A, 2000, Annals of the New York Academy of Sciences, 911, 369-391. A2 Review article, Literature review, Systematic review -
[11C]Flumazenil binding in the medical temporal lobe in patients with temporal lobe epilepsy. Correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology
Lamusuo S, Pitkänen A, Jutila L, Ylinen A, Partanen K, Kälviäinen R, Ruottinen H-M, Oikonen V, Någren K, Lehikoinen P, Vapalahti M, Vainio P, Rinne JO, 2000, Neurology, 54, 2252-2260. A1 Journal article (refereed), original research -
Distribution of GABAergic cells and fibers in the hippocampal formation of the macaque monkey: an immunohistochemical and in situ hybridization study
Jongen-Rêlo AL, Pitkänen A, Amaral DG, 1999, Journal of comparative neurology, 408, 237-271. A1 Journal article (refereed), original research -
Do GABAergic circuitries play a critical role in the regulation of seizure-induced neuronal damage and synaptic reorganization in the rat hippocampus?
Pitkänen A, Jolkkonen J, 1999, ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY. SUPPLEMENT, 50, 443-449. A1 Journal article (refereed), original research -
Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus
Pitkänen A, Nissinen J, Jolkkonen E, Tuunanen J, Halonen T, 1999, Epilepsy research, 33, 67-85. A1 Journal article (refereed), original research -
Epilepsian geenit ja neurobiologia
Lehesjoki A-E, Pitkänen A, 1999, Duodecim, 115, 583-594. A1 Journal article (refereed), original research -
Neuroprotective effect of remacemide hydrochloride in a perforant pathway stimulation model of status epilepticus in the rat
Halonen T, Nissinen J, Pitkänen A, 1999, Epilepsy research, 34, 251-269. A1 Journal article (refereed), original research -
Prevention of seizure-induced neuronal damage and intellectual deterioration: experimental aspects and clinical implications
Kälviäinen R, Pitkänen A, 1999, Sillanpää M, Gram L, Johannessen SI, Tomson T, Epilepsy and Mental Retardation, 165 - 178. A3 Book section, Chapters in research books -
Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the hippocampal formation in rat
Pikkarainen M, Rönkkö S, Savander V, Insausti R, Pitkänen A, 1999, Journal of comparative neurology, 403, 229-260. A1 Journal article (refereed), original research -
Quantitative magnetic resonance imaging assessment of cerebral ischemia in rat using on-resonance T1 in the rotating frame
Gröhn OHJ, Lukkarinen JA, Silvennoinen MJ, Pitkänen A, van Zijl PCM, Kauppinen RA, 1999, Magnetic resonance in medicine, 42, 268-276. A1 Journal article (refereed), original research -
Seizure-induced damage to the medial temporal lobe in temporal lobe epilepsy
Pitkänen A, Salmenperä T, Äikiä M, Partanen K, Kälviäinen R, 1999, Sillanpää M, Gram L, Johannessen SI, Tomson T, Epilepsy and Mental Retardation, 147-163. A3 Book section, Chapters in research books -
Status epilepticus-induced neuronal damage in the rat amygdaloid complex: distribution, time-course and mechanisms
Tuunanen J, Lukasiuk K, Halonen T, Pitkänen A, 1999, Neuroscience, 94, 2, 473-495. A1 Journal article (refereed), original research -
Amygdala damage in experimental and human temporal lobe epilepsy
Pitkänen A, Tuunanen J, Kälviäinen R, Partanen K, Salmenperä T, 1998, Epilepsy research, 32, 233-253. A2 Review article, Literature review, Systematic review -
Calretinin-immunoreactive terminals make synapses on calbindin D28k-immunoreactive neurons in the lateral nucleus of the human amygdala
Sorvari H, Miettinen R, Soininen H, Paljärvi L, Karkola K, Pitkänen A, 1998, Brain research, 783, 355-358. A1 Journal article (refereed), original research -
Hippocampal damage caused by seizures in temporal lobe epilepsy
Salmenperä T, Kälviäinen R, Partanen K, Pitkänen A, 1998, The Lancet. -
Intrinsic connections of the rat amygdaloid complex: projections originating in the central nucleus
Jolkkonen E, Pitkänen A, 1998, Journal of comparative neurology, 395, 53-72. A1 Journal article (refereed), original research -
MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices
Insausti R, Juottonen K, Soininen H, Insausti AM, Partanen K, Vainio P, Laakso MP, Pitkänen A, 1998, American journal of neuroradiology, 19, 659-671. A1 Journal article (refereed), original research -
Mantelitumake
Pitkänen A, 1998, Duodecim, 114, 2451-2459. A2 Review article, Literature review, Systematic review -
Organization of the intrinsic connections of the monkey amygdaloid complex: projections originating in the lateral nucleus
Pitkänen A, Amaral DG, 1998, Journal of comparative neurology, 398, 431-458. A1 Journal article (refereed), original research -
Prevention of epilepsy
Pitkänen A, Halonen T, 1998, Trends in pharmacological sciences, 19, 253-254. A1 Journal article (refereed), original research -
Recurrent seizures may cause hippocampal damage in temporal lobe epilepsy
Kälviäinen R, Salmenperä T, Partanen K, Vainio P, Riekkinen P Sr, Pitkänen A, 1998, Neurology, 50, 1377-1382. A1 Journal article (refereed), original research -
Remodeling of neuronal circuitries in human temporal lobe epilepsy: increased expression of highly polysialylated neural cell adhesion molecule in the hippocampus and the entorhinal cortex
Mikkonen M, Soininen H, Kälviäinen R, Tapiola T, Ylinen A, Vapalahti M, Paljärvi L, Pitkänen A, 1998, Annals of neurology, 44, 923-934. A1 Journal article (refereed), original research -
Volumes of the entorhinal and perirhinal cortices in Alzheimer`s disease
Juottonen K, Laakso MP, Insausti R, Lehtovirta M, Pitkänen A, Partanen K, Soininen H, 1998, Neurobiology of aging, 19, 1, 15-22. A1 Journal article (refereed), original research -
Cholinergic deafferentation exacerbates seizure-induced loss of somatostatin-immunoreactive neurons in the rat hippocampus
Jolkkonen J, Kähkönen K, Pitkänen A, 1997, Neuroscience, 80, 2, 401-411. A1 Journal article (refereed), original research -
Decrease in somatostatin-immunoreactive neurons in the rat amygdaloid complex in a kindling model of temporal lobe epilepsy
Tuunanen J, Halonen T, Pitkänen A, 1997, Epilepsy research, 26, 315-327. A1 Journal article (refereed), original research -
Distribution of calretinin-immunoreactivity in the rat entorhinal cortex:coexistence with GABA
Miettinen M, Pitkänen A, Miettinen R, 1997, Journal of comparative neurology, 378, 363-378. A1 Journal article (refereed), original research -
Distribution of parvalbumin-, calretinin-, and calbindin-D28k-immunoreactive neurons and fibers in the human entorhinal cortex
Mikkonen M, Soininen H, Pitkänen A, 1997, Journal of comparative neurology, 388, 64-88. A1 Journal article (refereed), original research -
Interamygdaloid projections of the basal and accessory basal nuclei of the rat amygdaloid complex
Savander V, Ledoux JE, Pitkänen A, 1997, Neuroscience, 76, 3, 725-735. A1 Journal article (refereed), original research -
Lateral nucleus of the rat amygdala is reciprocally connected with basal and accessory basal nuclei: a light and electron microscopic study
Savander V, Miettinen R, Ledoux JE, Pitkänen A, 1997, Neuroscience, 77, 3, 767-781. A1 Journal article (refereed), original research -
MRI volumetry and T2 relaxometry of the amygdala in newly diagnosed and chronic temporal lobe epilepsy
Kälviäinen R, Salmenperä T, Partanen K, Vainio P, Riekkinen P Sr, Pitkänen A, 1997, Epilepsy research, 28, 39-50. A1 Journal article (refereed), original research -
MRI-based hippocampal volumetry and T2 relaxometry: correlation to verbal memory performance in newly diagnosed epilepsy patients with left-sided temporal lobe focus
Kälviäinen R, Partanen K, Äikiä M, Mervaala E, Vainio P, Riekkinen PJ Sr, Pitkänen A, 1997, Neurology, 48, 286-287. A1 Journal article (refereed), original research -
Organization of intra-amygdaloid circuitries in the rat: an emerging framework for understanding functions of the amygdala
Pitkänen A, Savander V, Ledoux JE, 1997, Trends in neurosciences, 20, 11, 517-523. A1 Journal article (refereed), original research -
Seizure-induced damage to somatostatin-immunoreactive neurons in the rat hippocampus is regulated by fimbria-fornix transection
Jolkkonen J, Jolkkonen E, Pitkänen A, 1997, Experimental neurology, 145, 141-153. A1 Journal article (refereed), original research -
Calbindin-D28K-immunoreactive cells and fibres in the human amygdaloid complex
Sorvari H, Soininen H, Pitkänen A, 1996, Neuroscience, 75, 2, 421-443. A1 Journal article (refereed), original research -
Calretinin-immunoreactive cells and fibers in the human amygdaloid complex
Sorvari H, Soininen H, Pitkänen A, 1996, Journal of comparative neurology, 369, 188-208. A1 Journal article (refereed), original research -
Intrinsic connections of the rat amygdaloid complex: projections originating in the accessory basal nucleus
Savander V, Go C-G, Ledoux JE, Pitkänen A, 1996, Journal of comparative neurology, 374, 291-313. A1 Journal article (refereed), original research -
Parvalbumin-immunoreactive neurons make inhibitory synapses on pyramidal cells in the human amygdala: a light and electron microscopic study
Sorvari H, Miettinen R, Soininen H, Pitkänen A, 1996, Neuroscience letters, 217, 93-96. A1 Journal article (refereed), original research -
Seizure-induced damage to the hippocampus is prevented by modulation of the GABAergic system
Jolkkonen J, Halonen T, Jolkkonen E, Nissinen J, Pitkänen A, 1996, Neuroreport, 7, 2031-2035. A1 Journal article (refereed), original research -
Severity of hippocampal atrophy correlates with the prolongation of MRI T2 relaxation time in temporal lobe epilepsy but not in Alzheimer's disease
Pitkänen A, Laakso M, Kälviäinen R, Partanen K, Vainio P, Lehtovirta M, Riekkinen P Sr, Soininen H, 1996, Neurology, 46, 1724-1730. A1 Journal article (refereed), original research -
Status epilepticus causes selective regional damage and loss of GABAergic neurons in the rat amygdaloid complex
Tuunanen J, Halonen T, Pitkänen A, 1996, European journal of neuroscience, 8, 2711-2725. A1 Journal article (refereed), original research -
Tiagabine prevents seizures, neuronal damage and memory impairment in experimental status epilepticus
Halonen T, Nissinen J, Jansen JA, Pitkänen A, 1996, European journal of pharmacology, 299, 69-81. A1 Journal article (refereed), original research -
Topographic projections from the periamygdaloid cortex to select subregions of the lateral nucleus of the amygdala in the rat
Savander V, LeDoux JE, Pitkänen A, 1996, Neuroscience letters, 211, 167-170. A1 Journal article (refereed), original research -
Treatment with antiepileptic drugs: Possible neuroprotective effects
Pitkänen A, 1996, NEUROLOGY. SUPPLEMENT, 47, 1, S12-S16. A1 Journal article (refereed), original research -
Vigabatrin and carbamazepine have different efficacies in the prevention of status epilepticus induced neuronal damage in the hippocampus and amygdala
Pitkänen A, Tuunanen J, Halonen T, 1996, Epilepsy research, 24, 29-45. A1 Journal article (refereed), original research -
Abnormal regional benzodiazepine receptor uptake in the prefrontal cortex in patients with panic disorder
Kuikka JT, Pitkänen A, Lepola U, Partanen K, Vainio P, Bergström KA, Wieler HJ, Kaiser KP, Mittelbach L, Koponen H, Leinonen E, Riekkinen PJ, 1995, Nuclear medicine communications, 16, 273-280. A1 Journal article (refereed), original research -
Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E epsilon 4 allele
Soininen H, Partanen K, Pitkänen A, Hallikainen M, Hänninen T, Helisalmi S, Mannermaa A, Ryynänen M, Koivisto K, Riekkinen P Sr, 1995, Neurology, 45, 391-392. A1 Journal article (refereed), original research -
Distribution of parvalbumin-immunoreactive cells and fibers in the human amygdaloid complex
Sorvari H, Soininen H, Paljärvi L, Karkola K, Pitkänen A, 1995, Journal of comparative neurology, 360, 185-212. A1 Journal article (refereed), original research -
Intrinsic connections of the rat amygdaloid complex: projections originating in the basal nucleus
Savander V, Go C-G, LeDoux JE, Pitkänen A, 1995, Journal of comparative neurology, 361, 345-368. A1 Journal article (refereed), original research -
Intrinsic connections of the rat amygdaloid complex: projections originating in the lateral nucleus
Pitkänen A, Stefanacci L, Farb CR, Go GG, LeDoux JE, Amaral DG, 1995, Journal of comparative neurology, 356, 288-310. A1 Journal article (refereed), original research -
Subiculum, presubiculum and parasubiculum have different sensitivities to seizure-induced neuronal damage in the rat
Pitkänen A, Tuunanen J, Halonen T, 1995, Neuroscience letters, 192, 65-68. A1 Journal article (refereed), original research