Astrid Subrizi
Academy Research Fellow
School of Pharmacy, Faculty of Health Sciences
astrid.subrizi@uef.fi | +358 40 355 2093
I study and develop ocular drug delivery systems. I am interested in the design and functionality of nanocarriers, in the selection of targeting moieties that facilitate safe and precise delivery of drugs to ocular tissues, and in the investigation of ocular barriers and their effects on ocular pharmacokinetics.
Research groups
Publications
11 items-
Intravitreal CendR peptides target laser-induced choroidal neovascularization sites in mice
Puranen, Jooseppi; Korhonen, Sonja; Haugas, Maarja; Lingasamy, Prakash; Teesalu, Tambet; Subrizi, Astrid; Urtti, Arto; Ruponen, Marika; Reinisalo, Mika. 2023. Journal of controlled release. 360: 810-817 -
Tailoring surface properties of liposomes for dexamethasone intraocular administration
Al-Amin, M.D.; Mastrotto, Francesca; Subrizi, Astrid; Sen, Merve; Turunen, Tiina; Arango-Gonzalez, Blanca; Ueffing, Marius; Malfanti, Alessio; Urtti, Arto; Salmaso, Stefano; Caliceti, Paolo. 2023. Journal of controlled release. 354: 323-336 -
Cowpea Chlorotic Mottle Virus-Like Particles as Potential Platform for Antisense Oligonucleotide Delivery in Posterior Segment Ocular Diseases
Pretto, Chiara; Tang, Miao; Chen, Mei; Xu, Heping; Subrizi, Astrid; Urtti, Arto; Hest, Jan CM. 2021. Macromolecular bioscience. 21: 2100095 -
Pharmacokinetics of intravitreal macromolecules: scaling between rats and rabbits
Sadeghi, Amir; Puranen, Jooseppi; Ruponen, Marika; Valtari, Annika; Subrizi, Astrid; Ranta, Veli-Pekka; Toropainen, Elisa; Urtti, Arto. 2021. European journal of pharmaceutical sciences. 159: 105720 -
Screening of chemical linkers for development of pullulan bioconjugates for intravitreal ocular
Balasso, Anna; Subrizi, Astrid; Salmaso, Stefano; Mastrotto, Francesca; Garofalo, Mariangela; Tang, Miao; Chen, Mei; Xu, Heping; Urtti, Arto; Caliceti, Paolo. 2021. European journal of pharmaceutical sciences. 161: 105785 -
Avoiding the Pitfalls of siRNA Delivery to the Retinal Pigment Epithelium with Physiologically Relevant Cell Models.
Ramsay, Eva; Raviña, Manuela; Sarkhel, Sanjay; Hehir, Sarah; Cameron, Neil R; Ilmarinen, Tanja; Skottman, Heli; Kjems, Jørgen; Urtti, Arto; Ruponen, Marika; Subrizi, Astrid. 2020. Pharmaceutics. 12: 667 -
Diffusion and Protein Corona Formation of Lipid-Based Nanoparticles in the Vitreous Humor: Profiling and Pharmacokinetic Considerations
Tavakoli, Shirin; Kari, Otto Kalevi; Turunen, Tiina; Lajunen, Tatu; Schmitt, Mechthild; Lehtinen, Julia; Tasaka, Fumitaka; Parkkila, Petteri; Ndika, Joseph; Viitala, Tapani; Alenius, Harri; Urtti, Arto; Subrizi, Astrid. 2020. Molecular pharmaceutics. 2021; 18: 699-713 -
Extended Pharmacokinetic Model of the Intravitreal Injections of Macromolecules in Rabbits. Part 2: Parameter Estimation Based on Concentration Dynamics in the Vitreous, Retina, and Aqueous Humor
Lamminsalo, Marko; Karvinen, Timo; Subrizi, Astrid; Urtti, Arto; Ranta, Veli-Pekka. 2020. Pharmaceutical research. 37: 226 -
Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties
Subrizi, A; Amo, EMD; Korzhakov-Vlakh, V; Tennikova, T; Ruponen, M; Urtti, A. 2019. Drug discovery today. 24: 1446-1457 -
Nucleic acid delivery to differentiated retinal pigment epithelial cells using cell-penetrating peptide as a carrier
Subia, B; Reinisalo, M; Dey, N; Tavakoli, S; Subrizi, A; Ganguli, M; Ruponen, M. 2019. European journal of pharmaceutics and biopharmaceutics. 140: 91-99