Astrid Subrizi
Academy Research Fellow
Faculty of Health Sciences, School of Pharmacy
astrid.subrizi@uef.fi | +358 40 355 2093
I study and develop ocular drug delivery systems. I am interested in the design and functionality of nanocarriers, in the selection of targeting moieties that facilitate safe and precise delivery of drugs to ocular tissues, and in the investigation of ocular barriers and their effects on ocular pharmacokinetics.
Research groups
Publications
10 items-
Tailoring surface properties of liposomes for dexamethasone intraocular administration
Al-Amin, M.D.; Mastrotto, Francesca; Subrizi, Astrid; Sen, Merve; Turunen, Tiina; Arango-Gonzalez, Blanca; Ueffing, Marius; Malfanti, Alessio; Urtti, Arto; Salmaso, Stefano; Caliceti, Paolo. 2023. Journal of controlled release. 354: 323-336 A1 Journal article (refereed), original research -
Cowpea Chlorotic Mottle Virus-Like Particles as Potential Platform for Antisense Oligonucleotide Delivery in Posterior Segment Ocular Diseases
Pretto, Chiara; Tang, Miao; Chen, Mei; Xu, Heping; Subrizi, Astrid; Urtti, Arto; Hest, Jan CM. 2021. Macromolecular bioscience. 21: 2100095 A1 Journal article (refereed), original research -
Pharmacokinetics of intravitreal macromolecules: scaling between rats and rabbits
Sadeghi, Amir; Puranen, Jooseppi; Ruponen, Marika; Valtari, Annika; Subrizi, Astrid; Ranta, Veli-Pekka; Toropainen, Elisa; Urtti, Arto. 2021. European journal of pharmaceutical sciences. 159: 105720 A1 Journal article (refereed), original research -
Screening of chemical linkers for development of pullulan bioconjugates for intravitreal ocular
Balasso, Anna; Subrizi, Astrid; Salmaso, Stefano; Mastrotto, Francesca; Garofalo, Mariangela; Tang, Miao; Chen, Mei; Xu, Heping; Urtti, Arto; Caliceti, Paolo. 2021. European journal of pharmaceutical sciences. 161: 105785 A1 Journal article (refereed), original research -
Avoiding the Pitfalls of siRNA Delivery to the Retinal Pigment Epithelium with Physiologically Relevant Cell Models.
Ramsay, Eva; Raviña, Manuela; Sarkhel, Sanjay; Hehir, Sarah; Cameron, Neil R; Ilmarinen, Tanja; Skottman, Heli; Kjems, Jørgen; Urtti, Arto; Ruponen, Marika; Subrizi, Astrid. 2020. Pharmaceutics. 12: 667 A1 Journal article (refereed), original research -
Diffusion and Protein Corona Formation of Lipid-Based Nanoparticles in the Vitreous Humor: Profiling and Pharmacokinetic Considerations
Tavakoli, Shirin; Kari, Otto Kalevi; Turunen, Tiina; Lajunen, Tatu; Schmitt, Mechthild; Lehtinen, Julia; Tasaka, Fumitaka; Parkkila, Petteri; Ndika, Joseph; Viitala, Tapani; Alenius, Harri; Urtti, Arto; Subrizi, Astrid. 2020. Molecular pharmaceutics. 2021; 18: 699-713 A1 Journal article (refereed), original research -
Extended Pharmacokinetic Model of the Intravitreal Injections of Macromolecules in Rabbits. Part 2: Parameter Estimation Based on Concentration Dynamics in the Vitreous, Retina, and Aqueous Humor
Lamminsalo, Marko; Karvinen, Timo; Subrizi, Astrid; Urtti, Arto; Ranta, Veli-Pekka. 2020. Pharmaceutical research. 37: 226 A1 Journal article (refereed), original research -
Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties
Subrizi, A; Amo, EMD; Korzhakov-Vlakh, V; Tennikova, T; Ruponen, M; Urtti, A. 2019. Drug discovery today. 24: 1446-1457 A2 Review article, Literature review, Systematic review -
Nucleic acid delivery to differentiated retinal pigment epithelial cells using cell-penetrating peptide as a carrier
Subia, B; Reinisalo, M; Dey, N; Tavakoli, S; Subrizi, A; Ganguli, M; Ruponen, M. 2019. European journal of pharmaceutics and biopharmaceutics. 140: 91-99 A1 Journal article (refereed), original research -
Pharmacokinetic aspects of retinal drug delivery
del Amo Eva M, Rimpelä Anna-Kaisa, Heikkinen Emma, Kari Otto K, Ramsay Eva, Lajunen Tatu, Schmitt Mechthild, Pelkonen Laura, Bhattacharya Madhushree, Richardson Dominique, Subrizi Astrid, Turunen Tiina, Reinisalo Mika, Itkonen Jaakko, Toropainen Elisa, Casteleijn Marco, Kidron Heidi, Antopolsky Maxim, Vellonen Kati-Sisko, Ruponen Marika, et al.. 2017. Progress in retinal and eye research. 57: 134-185 A2 Review article, Literature review, Systematic review