Atte Seppo Aleksi Eskelinen
Postdoctoral Researcher
Postdoctoral researcher
Department of Technical Physics, Faculty of Science, Forestry and Technology
atte.eskelinen@uef.fi
I am currently a postdoctoral researcher in the fields of biomechanics, mechanobiology, computational modeling, musculoskeletal diseases, and osteoarthritis. My current research interests include experimental and computational modeling of cartilage degradation, and biomechanical and inflammatory mechanisms in osteoarthritis and joint pain. The aim of the current research project is to develop personalized predictive models of osteoarthritis progression and pain to optimize treatment strategies for pain-free, improved musculoskeletal healthcare.
Research groups
Publications
15/15 items-
Injury-related cell death and proteoglycan loss in articular cartilage: Numerical model combining necrosis, reactive oxygen species, and inflammatory cytokines
Kosonen, Joonas P.; Eskelinen, Atte S. A; Orozco, Gustavo A.; Nieminen, Petteri; Anderson, Donald D; Grodzinsky, Alan J; Korhonen, Rami K; Tanska, Petri. 2023. PLoS computational biology. 19: -
Knee cartilage mechanics in finite element analysis using inputs from different musculoskeletal software
Joose Peitola; Amir Esrafilian; Atte Eskelinen; Michael Skipper Andersen; Rami Korhonen. 2023. -
Multiscale In Silico Modeling of Cartilage Injuries
Korhonen, Rami K; Eskelinen, Atte SA; Orozco, Gustavo A; Esrafilian, Amir; Florea, Cristina; Tanska, Petri. Teoksessa: Connizzo, BK; Han, L; Sah, RL(toim.) , 2023. Electromechanobiology of Cartilage and Osteoarthritis : A Tribute to Alan Grodzinsky on his 75th Birthday. s. 45-56. Springer -
Biomechanics and inflammation - Regulators of articular cartilage degradation: Models aiming towards comprehensive prediction of post-traumatic osteoarthritis progression
Eskelinen, Atte. 2022. Publications of the University of Eastern Finland. Dissertations in Forestry and Natural Sciences -
Cyclic loading regime considered beneficial does not protect injured and interleukin-1-inflamed cartilage from post-traumatic osteoarthritis
Eskelinen, Atte SA; Florea, Cristina; Tanska, Petri; Hung, Han-Hwa K.; Frank, Eliot H.; Mikkonen, Santtu; Nieminen, Petteri; Julkunen, Petro; Grodzinsky, Alan J.; Korhonen, Rami K.. 2022. Journal of biomechanics. 141: -
Reduction of pro-inflammatory cytokine activity results in proteoglycan content recovery in a computational model of injured articular cartilage implementing cytokines and reactive oxygen species
Kosonen, Joonas; Eskelinen, Atte; Orozco, Gustavo; Anderson, Donald; Grodzinsky, Alan; Tanska, Petri; Korhonen, Rami. 2022. Orthopaedic Research Society -
A mechanobiological model combining inflammation and biomechanical stimulus to predict cell death and subsequent proteoglycan loss in articular cartilage after traumatic injury
Kosonen JP, Eskelinen ASA, Orozco GA, Nieminen P, Grodzinsky AJ, Korhonen RK, Tanska P. 2021. -
Cartilage lesions and interleukin-1-driven inflammation abrogate the beneficial effects of moderate dynamic loading in a bovine cartilage model of post-traumatic osteoarthritis
Eskelinen ASA, Florea C, Mikkonen S, Nieminen P, Julkunen P, Tanska P, Grodzinsky AJ, Korhonen RK. 2021. -
Shear strain and inflammation-induced fixed charge density loss in the knee joint cartilage following ACL injury and reconstruction: A computational study
Orozco, Gustavo A; Eskelinen, Atte SA; Kosonen, Joonas P; Tanaka, Matthew S; Yang, Mingrui; Link, Thomas M; Ma, Benjamin; Li, Xiaojuan; Grodzinsky, Alan J; Korhonen, Rami K; Tanska, Petri. 2021. Journal of orthopaedic research. [Epub ahead of print 17 Sept 2021]: 1-18 -
Mechanobiological Model for Simulation of Injured Cartilage Degradation via Pro-Inflammatory Cytokines and Mechanical Stimulus
Eskelinen, ASA; Tanska, P; Florea, C; Orozco, GA; Julkunen, P; Grodzinsky, AJ; Korhonen, RK. 2020. PLoS computational biology. 16: 1007998