ATTE ESKELINEN

Postdoctoral Researcher

Junior Researcher (Science, Technology and Computing – SCITECO)

ISB / ASB 2019 - Scroll down for link to electronic poster and animations of cartilage degradation over time

I am a PhD student with a research interest in developing an adaptive mechanobiological algorithm for prediction of osteoarthritis progression. The novel algorithm considers cartilage degradation via tissue inflammation and abnormal biomechanics. Calibration and validation of the algorithm is done against extensive experimental findings. In my research I use COMSOL Multiphysics and Abaqus for the finite element analysis.

Contact info

Organization

Faculty of Science and Forestry, Department of Applied Physics

Email

attees@uef.fi

Phone

Keywords

cartilage cytokine finite element analysis inflammation mechanical strain osteoarthritis

Research groups - UEF

Biophysics of Bone and Cartilage (BBC)

Publications

A mechanobiological model combining inflammation and biomechanical stimulus to predict cell death and subsequent proteoglycan loss in articular cartilage after traumatic injury. Kosonen JP, Eskelinen ASA, Orozco GA, Nieminen P, Grodzinsky AJ, Korhonen RK, Tanska P / Transactions of the Orthopaedic Research Society. 2021. 2021
Cartilage lesions and interleukin-1-driven inflammation abrogate the beneficial effects of moderate dynamic loading in a bovine cartilage model of post-traumatic osteoarthritis. Eskelinen ASA, Florea C, Mikkonen S, Nieminen P, Julkunen P, Tanska P, Grodzinsky AJ, Korhonen RK / Transactions of the Orthopaedic Research Society. 2021. 2021
Orozco, Gustavo A; Eskelinen, Atte SA; Kosonen, Joonas P; Tanaka, Matthew S; Yang, Mingrui; Link, Thomas M; Ma, Benjamin; Li, Xiaojuan; Grodzinsky, Alan J; Korhonen, Rami K; Tanska, Petri. 2021. Shear strain and inflammation-induced fixed charge density loss in the knee joint cartilage following ACL injury and reconstruction: A computational study Journal of orthopaedic research [Epub ahead of print 17 Sept 2021]: 1-18. 2021
Eskelinen, ASA; Tanska, P; Florea, C; Orozco, GA; Julkunen, P; Grodzinsky, AJ; Korhonen, RK. 2020. Mechanobiological Model for Simulation of Injured Cartilage Degradation via Pro-Inflammatory Cytokines and Mechanical Stimulus PLoS computational biology 16 6: 1007998. 2020
Mechanobiological model combining inflammation and abnormal mechanical loading predicts local cartilage degeneration around lesion. Kosonen JP, Eskelinen ASA, Orozco GA, Tanska P, Yang M, Tanaka MS, Ma B, Li X, Grodzinsky AJ, Korhonen RK / Transactions of the Orthopaedic Research Society. 2020. 2020
Combining mechanical stimulus and cytokine-mediated degradation mechanisms in injured cartilage. Eskelinen ASA, Orozco GA, Tanska P, Grodzinsky AJ, Korhonen RK / Transactions of the Orthopaedic Research Society. 2019. 2019
Eskelinen, ASA; Mononen, ME; Venäläinen, MS; Korhonen, RK; Tanska, P. 2019. Maximum shear strain-based algorithm can predict proteoglycan loss in damaged articular cartilage Biomechanics and modeling in mechanobiology 18 3: 753-778. 2019
Mechanisms to reveal how normal dynamic loading causes proteoglycan loss in mechanically injured cartilage: A mechanobiological model combined with experimental findings. Orozco GA, Tanska P, Eskelinen ASA, Florea C, Grodzinsky AJ, Korhonen RK / Transactions of the Orthopaedic Research Society. 2018. 2018
Shear strain can trigger proteoglycan loss in injured cartilage. Eskelinen ASA, Tanska P, Mononen ME, Venäläinen M, Korhonen RK / Transactions of the Orthopaedic Research Society. 2017. 2017