CARSTEN CARLBERG

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Teaching Activities

Publications

• Carlberg, Carsten; Muñoz, Alberto. 2021. An update on vitamin D signaling and cancer Seminars in cancer biology [Online ahead of print]: -. 2021
• Carlberg, Carsten; Ulven, Stine Marie; Molnár, Ferdinand (ed.) . 2020. Nutrigenomics: How Science works. Springer. 2020
• Dumo, AM; Laing, B; Lim, AG; Palaganas, E; Abad, PJ; Valdehueza, O; Palovaara, M; Saunders, H; Estola, M; Mandysova, P; Maguire, J; Ward, LD; Carlberg, C; Vehviläinen-Julkunen, K. 2020. Randomized controlled trial on the effectiveness of web-based Genomics Nursing Education Intervention for undergraduate nursing students: a study protocol Journal of advanced nursing 76 11: 3136-3146. 2020
• Hanel, Andrea; Carlberg, Carsten. 2020. Skin Color and Vitamin D: An Update Experimental dermatology 29 9: 864-875. 2020
• Hanel, Andrea; Carlberg, Carsten. 2020. Vitamin D and evolution: pharmacologic implications Biochemical pharmacology 173: 113595. 2020
• Hanel, Andrea; Malmberg, Henna-Riikka; Carlberg, Carsten. 2020. Genome-wide effects of chromatin on vitamin D signaling Journal of molecular endocrinology 64 4: R45-R56. 2020
• Hanel, Andrea; Neme, Antonio; Malinen, Marjo; Hämäläinen, Emmi; Malmberg, Henna-Riikka; Etheve, Stéphane; Tuomainen, Tomi-Pekka; Virtanen, Jyrki K; Bendik, Igor; Carlberg, Carsten. 2020. Common and personal target genes of the micronutrient vitamin D in primary immune cells from human peripheral blood Scientific reports 10 1: 21051. 2020
• Koivisto, Oona; Hanel, Andrea; Carlberg, Carsten. 2020. Key Vitamin D Target Genes With Functions in the Immune System Nutrients 12 4: 1140. 2020
• Monitoring genome-wide chromatin accessibility by formaldehyde-assisted isolation of regulatory elements sequencing (FAIRE-seq). Seuter, Sabine; Neme, Antonio; Carlberg, Carsten / Epigenetics Methods. 2020. 2020
• Velleuer, Eunike; Carlberg, Carsten. 2020. Impact of Epigenetics on Complications of Fanconi Anemia: The Role of Vitamin D-Modulated Immunity Nutrients 12 5: 1355. 2020
• Zmijewski, MA; Carlberg, C. 2020. Vitamin D receptor(s): in the nucleus but also at membranes? Experimental dermatology 29 9: 876-884. 2020
• Carlberg, Carsten; Molnár, Ferdinand (ed.) . 2020. Mechanisms of Gene Regulation: How Science works. Springer Nature. 2020
• Myhrstad, MC; de Mello, VD; Dahlman, I; Kolehmainen, M; Paananen, J; Rundblad, A; Carlberg, C; Olstad, OK; Pihlajamäki, J; Holven, KB; Hermansen, K; Dragsted, LO; Gunnarsdottir, I; Cloetens, L; Storm, MU; Åkesson, B; Rosqvist, F; Hukkanen, J; et al. (incl. Schwab, U; Uusitupa, M). 2019. Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with the Metabolic Syndrome - A SYSDIET Sub-Study Molecular nutrition and food research 63 13: 1801405. 2019
• Ulven, SM; Holven, KB; Rundblad, A; Myhrstad, MCW; Leder, L; Dahlman, I; Mello, VD; Schwab, U; Carlberg, C; Pihlajamäki, J; Hermansen, K; Dragsted, LO; Gunnarsdottir, I; Cloetens, L; Åkesson, B; Rosqvist, F; Hukkanen, J; Herzig, KH; Savolainen, MJ; Risérus, U; et al. [incl. Uusitupa, M]. 2019. An Isocaloric Nordic Diet Modulates RELA and TNFRSF1A Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome-A SYSDIET Sub-Study Nutrients 11 12: 2932. 2019
• Nurminen, V; Seuter, S; Carlberg, C. 2019. Primary Vitamin D Target Genes of Human Monocytes Frontiers in physiology 10: 194. 2019
• Neme, Antonio; Seuter, Sabine; Malinen, Marjo; Nurmi, Tarja; Tuomainen, Tomi-Pekka; Virtanen, Jyrki K; Carlberg, Carsten. 2019. In vivo transcriptome changes of human white blood cells in response to vitamin D Journal of steroid biochemistry and molecular biology 188: 71-76. 2019
• Maestro, Miguel A; Molnár, Ferdinand; Carlberg, Carsten. 2019. Vitamin D and Its Synthetic Analogs Journal of medicinal chemistry 62 15: 6854-6875. 2019
• Carlberg, Carsten. 2019. Nutrigenomics of Vitamin D Nutrients 11 3: 676. 2019
• Fleet, JC; Campbell, MJ; Carlberg, C; Demay, MB; Ebeling, PR; Schoenmakers, I; White, JH; Welsh, J; Hewison, M. 2019. Highlights from the 21st Workshop on Vitamin D in Barcelona, May 2018 Journal of steroid biochemistry and molecular biology 189: 210-217. 2019
• Carlberg, Carsten. 2019. Vitamin D: A Micronutrient Regulating Genes Current pharmaceutical design 25 15: 1740-1746. 2019
• Carlberg, Carsten. 2019. Vitamin D Signaling in the Context of Innate Immunity: Focus on Human Monocytes Frontiers in immunology 10: 2211. 2019
• Fleet, JC; Kovalenko, PL; Li, Y; Smolinski, J; Spees, C; Yu, JG; Thomas-Ahner, JM; Cui, M; Neme, A; Carlberg, C; Clinton, SK. 2019. Vitamin D Signaling Suppresses Early Prostate Carcinogenesis in TgAPT121 Mice Cancer prevention research 12 6: 343-356. 2019
• Carlberg, Carsten; Seuter, Sabine; Nurmi, Tarja; Tuomainen, Tomi-Pekka; Virtanen, Jyrki K; Neme, Antonio. 2018. In vivo response of the human epigenome to vitamin D: A proof-of-principle study Journal of steroid biochemistry and molecular biology 180: 142-148. 2018
• Carlberg, Carsten. 2018. Vitamin D Genomics: From In Vitro to In Vivo. FRONTIERS IN ENDOCRINOLOGY 9: 250. 2018
• Carlberg, Carsten; Molnár, Ferdinand (ed.) . 2018. Human Epigenomics. Springer. 2018
• Carlberg, Carsten; Neme, Antonio. 2018. A Machine learning approaches infer vitamin D signaling: Critical impact of vitamin D receptor binding within topologically associated domains JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 2019; 15: 103-109. 2018
• Haq, Afrozul; Wimalawansa, Sunil J; Carlberg, Carsten. 2018. Highlights from the 6th International Conference on Vitamin D Deficiency, "Nutrition and Human Health", Abu Dhabi, United Arab Emirates, March 9-10, 2017 Journal of steroid biochemistry and molecular biology 180: 1-3. 2018
• Nurminen, Veijo; Neme, Antonio; Seuter, Sabine; Carlberg, Carsten. 2018. The impact of the vitamin D-modulated epigenome on VDR target gene regulation BIOCHIMICA ET BIOPHYSICA ACTA - GENE REGULATORY MECHANISMS 1861 8: 697-705. 2018
• Nurminen, Veijo; Neme, Antonio; Seuter, Sabine; Carlberg, Carsten. 2018. Modulation of vitamin D signaling by the pioneer factor CEBPA Biochimica et biophysica acta: gene regulatory mechanisms 2019; 1862 1: 96-106. 2018
• Seuter, Sabine; Neme, Antonie; Carlberg, Carsten. 2018. ETS transcription factor family member GABPA contributes to vitamin D receptor target gene regulation Journal of steroid biochemistry and molecular biology 177: 46-52. 2018
• Vitamin D. Carlberg, Carsten / Encyclopedia of Life Sciences (eLS). 2018. 2018
• Neme Antonio, Seuter Sabine, Carlberg Carsten. 2017. Selective regulation of biological processes by vitamin D based on the spatio-temporal cistrome of its receptor. BIOCHIMICA ET BIOPHYSICA ACTA - GENE REGULATORY MECHANISMS 1860 9: 952-961. 2017
• Singh PK, van den Berg PR, Long MD, Vreugdenhil A, Grieshober L, Ochs-Balcom HM, Wang J, Delcambre S, Heikkinen S, Carlberg C, Campbell MJ, Sucheston-Campbell LE. 2017. Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-kappaB binding that is linked to immune phenotypes. BMC Genomics 18 1: -. 2017
• Seuter S, Neme A, Carlberg C. 2017. Epigenomic PU.1-VDR crosstalk modulates vitamin D signaling. BIOCHIMICA ET BIOPHYSICA ACTA - GENE REGULATORY MECHANISMS 1860 4: 405-415. 2017
• Seuter Sabine, Virtanen Jyrki K, Nurmi Tarja, Pihlajamäki Jussi, Mursu Jaakko, Voutilainen Sari, Tuomainen Tomi-Pekka, Neme Antonio, Carlberg Carsten. 2017. Molecular evaluation of vitamin D responsiveness of healthy young adults. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 174: 314-321. 2017
• Haq A, Wimalawansa SJ, Carlberg C. 2017. Highlights from the 5th International Conference on Vitamin D Deficiency, Nutrition and Human Health, Abu Dhabi, United Arab Emirates, March 24-25, 2016. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 175: 1-3. 2017
• Carlberg Carsten. 2017. Molecular endocrinology of vitamin D on the epigenome level. MOLECULAR AND CELLULAR ENDOCRINOLOGY 453: 14-21. 2017
• Carlberg Carsten, Haq Afrozul. 2017. The concept of the personal vitamin D response index. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 2018; 175: 12-17. 2017
• Carlberg Carsten. 2017. Endocrine functions of vitamin D. MOLECULAR AND CELLULAR ENDOCRINOLOGY 453: 1-2. 2017
• Carlberg Carsten. 2017. Vitamin D and chromatin. In: Feldman David, Pike J Wesley, Bouillon Roger, Giovannucci Edward, Goltzman David, Hewison Martin (ed.) Vitamin D. 4th Edition. Volume 1: Biochemistry, Physiology and Diagnostics. Elsevier. s. 217-226. 2017
• Carlberg Carsten. 2016. Vitamin D. In: Caplan Michael (ed.) Reference Module in Biomedical Sciences. Elsevier. s. -. 2016
• Kreienkamp Ray, Croke Monica, Neumann Martin A, Bedia-Diaz Gonzalo, Graziano Simona, Dusso Adriana, Dorsett Dale, Carlberg Carsten, Gonzalo Susana. 2016. Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes. Oncotarget 7 21: 30018-30031. 2016
• Leder Lena, Kolehmainen Marjukka, Narverud Ingunn, Dahlman Ingrid, Myhrstad Mari CW, de Mello Vanessa D, Paananen Jussi, Carlberg Castren, Schwab Ursula, Herzig Karl-Heinz, Cloetens Lieselotte, Storm Matilda Ulmius, Hukkanen Janne, Savolainen Markku J, Rosqvist Fredrik, Hermansen Kjeld, Dragsted Lars O, Gunnarsdottir Ingibjörk, Thorsdottir Inga, Risérus Ulf et al.. 2016. Effects of a healthy Nordic diet on gene expression changes in peripheral blood mononuclear cells in response to an oral glucose tolerance test in subjects with metabolic syndrome: a SYSDIET sub-study. Genes and Nutrition 11 3: 1-13. 2016
• Maestro Miguel A, Molnár Ferdinand, Mouriño Antonio, Carlberg Carsten. 2016. Vitamin D receptor 2016: novel ligands and structural insights. EXPERT OPINION ON THERAPEUTIC PATENTS 26 11: 1291-1306. 2016
• Mechanisms of gene regulation (2. ed). Carlberg Carsten, Molnár Ferdinand. 2016 2016
• Neme Antonio, Seuter Sabine, Carlberg Carsten. 2016. Vitamin D-dependent chromatin association of CTCF in human monocytes. BIOCHIMICA ET BIOPHYSICA ACTA - GENE REGULATORY MECHANISMS 1859 11: 1380-1388. 2016
• Nutrigenomics. Carlberg Carsten, Ulven Stine Marie, Molnár Ferdinand. 2016 2016
• Seuter Sabine, Neme Antonio, Carlberg Carsten. 2015. Epigenome-wide effects of vitamin D and their impact on the transcriptome of human monocytes involve CTCF. NUCLEIC ACIDS RESEARCH 2016; 44 9: 4090-4104. 2015
• Vukic Maja, Neme Antonio, Seuter Sabine, Saksa Noora, de Mello Vanessa DF, Nurmi Tarja, Uusitupa Matti, Tuomainen Tomi-Pekka, Virtanen Jyrki K, Carlberg Carsten. 2015. Relevance of Vitamin D Receptor Target Genes for Monitoring the Vitamin D Responsiveness of Primary Human Cells. PLOS ONE [ONLINE] 10 4: e0124339. 2015
• Carlberg Carsten, Molnár Ferdinand. 2015. Vitamin D receptor signaling and its therapeutic implications: Genome-wide and structural view. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 93 5: 311-318. 2015
• Rybakova Katja N, Bruggeman Frank J, Tomaszewska Aleksandra, Moné Martijn J, Carlberg Carsten, Westerfoff Hans V. 2015. Multiplex Eukaryotic Transcription (In) activation: Timing, Bursting and Cycling of a Ratchet Clock Mechanism. PLOS COMPUTATIONAL BIOLOGY 11 4: e1004236. 2015
• Neme Antonio, Nurminen Veijo, Seuter Sabine, Carlberg Carsten. 2015. The vitamin D-dependent transcriptome of human monocytes. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 2016; 164: 180-187. 2015
• Carlberg Carsten. 2015. Molecular approaches for optimizing vitamin D supplementation. VITAMINS AND HORMONES 2016; 100: 255-271. 2015
• Wilfinger Julia, Seuter Sabine, Tuomainen Tomi-Pekka, Virtanen Jyrki K, Voutilainen Sari, Nurmi Tarja, de Mello Vanessa DF, Uusitupa Matti, Carlberg Carsten. 2014. Primary vitamin D receptor target genes as biomarkers for the vitamin D3 status in the hematopoietic system. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 25 8: 875-884. 2014
• Tuoresmäki Pauli, Väisänen Sami, Neme Antonio, Heikkinen Sami, Carlberg Carsten. 2014. Patterns of Genome-Wide VDR Locations. PLOS ONE [ONLINE] 9 4: e96105. 2014
• Seuter Sabine, Neme Antonio, Carlberg Carsten. 2014. Characterization of genomic vitamin D receptor binding sites through chromatin looping and opening. PLOS ONE [ONLINE] 9 4: e96184. 2014
• Rybakova Katja N, Tomaszewska Aleksandra, van Mourik Simon, Blom Joke, Westerhoff Hans V, Carlberg Carsten, Bruggeman Frank J. 2014. Tracing the molecular basis of transcriptional dynamics in noisy data by using an experiment-based mathematical model. NUCLEIC ACIDS RESEARCH Epub ahead of print: -. 2014
• Saksa Noora, Neme Antonio, Ryynänen Jussi, Uusitupa Matti, de Mello Vanessa DF, Voutilainen Sari, Nurmi Tarja, Virtanen Jyrki K, Tuomainen Tomi-Pekka, Carlberg Carsten. 2014. Dissecting high from low responders in a vitamin D3 intervention study. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY Epub ahead of print: -. 2014
• Ryynänen Jussi, Neme Antonio, Tuomainen Tomi-Pekka, Virtanen Jyrki K, Voutilainen Sari, Nurmi Tarja, de Mello Vanessa DF, Uusitupa Matti, Carlberg Carsten. 2014. Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individuals. Molecular Nutrition & Food Research 58: 2036-2045. 2014
• Carlberg Carsten. 2014. The physiology of vitamin D - far more than calcium and bone. Frontiers in Physiology 5 335: -. 2014
• Nurminen Veijo, Neme Antonio, Ryynänen Jussi, Heikkinen Sami, Seuter Sabine, Carlberg Carsten. 2014. The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D. BIOCHIMICA ET BIOPHYSICA ACTA - GENE REGULATORY MECHANISMS Epub ahead of print: -. 2014
• Kolehmainen Marjukka, Ulven Stine M, Paananen Jussi, de Mello Vanessa, Schwab Ursula, Carlberg Carsten, Myhrstad Mari, Pihlajamäki Jussi, Dungner Elisabeth, Sjölin Eva, Gunnarsdottir Ingibjörg, Cloetens Lieselotte, Landin-Olsson Mona, Akesson Björn, Rosqvist Fredrik, Hukkanen Janne, Herzig Karl-Heinz, Dragsted Lars O, Savolainen Markku J, Brader Lea, Hermansen Kjeld, Risérus Ulf, Thorsdottir Inga,. 2014. Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome. AMERICAN JOURNAL OF CLINICAL NUTRITION 101 1 (2015): 228-239. 2014
• Carlberg Carsten. 2014. What Do We Learn from the Genome-wide Perspective on Vitamin D3?. ANTICANCER RESEARCH 48 4: 217-218. 2014
• Carlberg Carsten. 2014. Genome-wide (over)view on the actions of vitamin D. Frontiers in Physiology 5 164: 1-10. 2014
• Carlberg Carsten, Raunio Hannu. 2014. From pharmacogenomics to integrated personal omics profiling: a gap in implementation into healthcare. Personalized Medicine 11 7: 625-629. 2014
• Brader Lea, Rejnmark Lars, Carlberg Carsten, Schwab Ursula, Kolehmainen Marjukka, Rosqvist Fredrik, Cloetens Lieselotte, Landin-Olsson Mona, Gunnarsdottir Ingibjorg, Poutanen Kaisa S, Herzig Karl-Heinz, Risérus Ulf, Savolainen Markku J, Thorsdottir Inga, Uusitupa Matti, Hermansen Kjeld. 2014. Effects of a healthy Nordic diet on plasma 25-hydroxyvitamin D concentration in subjects with metabolic syndrome: a randomized, placebo-controlled trial (SYSDIET). EUROPEAN JOURNAL OF NUTRITION 53 4: 1123-34. 2014
• Mechanisms of Gene Regulation. Carlberg Carsten, Molnár Ferdinand. 2014 2014
• Seuter S, Pehkonen P, Heikkinen S, Carlberg C. 2013. Dynamics of 1α,25-dihydroxyvitamin D3-dependent chromatin accessibility of early vitamin D receptor target genes. BIOCHIMICA ET BIOPHYSICA ACTA 1829: 1266-1275. 2013
• Seuter S, Ryynänen J, Carlberg C. 2013. The ASAP2 gene is a primary target of 1,25-dihydroxyvitamin D3 in human monocytes and macrophages. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY [Epub ahead of print]: x-x. 2013
• Carlberg C, Seuter S, de Mello VDF, Schwab U, Voutilainen S, Pulkki K, Nurmi T, Virtanen J, Tuomainen T-P, Uusitupa M. 2013. Primary vitamin D target genes allow a categorization of possible benefits of vitamin D3 supplementation. PLOS ONE [ONLINE] 8 7: e71042. 2013
• Ryynänen J, Seuter S, Campbell MJ, Carlberg C. 2013. Gene Regulatory Scenarios of Primary 1,25-Dihydroxyvitamin D3 Target Genes in a Human Myeloid Leukemia Cell Line. Cancers 5: 1221-1241. 2013
• Ryynänen J, Carlberg C. 2013. Primary 1,25-Dihydroxyvitamin D3 Response of the Interleukin 8 Gene Cluster in Human Monocyte- and Macrophage-Like Cells. PLOS ONE [ONLINE] 8 10: e78170. 2013
• Carlberg C, Campbell MJ. 2013. Vitamin D receptor signaling mechanisms: Integrated actions of a well-defined transcription factor. STEROIDS (NEW YORK NY) 78: 127-136. 2013
• Lorente-Cebrián S, Eriksson A, Dunlop T, Mejhert N, Dahlman I, Åström G, Sjölin E, Wåhlén K, Carlberg C, Laurencikiene J, Hedén P, Arner P, Rydén M. 2012. Differential effects of 1alfa,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes. EUROPEAN JOURNAL OF NUTRITION 51: 335-342. 2012
• Seuter S, Heikkinen S, Carlberg C. 2012. Chromatin acetylation at transcription start sites and vitamin D receptor binding regions relates to effects of 1alfa,25-dihydroxyvitamin D3 and histone deacetylase inhibitors on gene expression. NUCLEIC ACIDS RESEARCH -: -. 2012
• Pehkonen P, Welter-Stahl L, Diwo J, Ryynänen J, Wienecke-Baldacchino A, Heikkinen S, Treuter E, Steffensen K, Carlberg C. 2012. Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages. BMC GENOMICS [ONLINE:HTTP://WWW.BIOMEDCENTRAL.COM/BMCGENOMICS/] 13 50: -. 2012
• Mutt SJ, Karhu T, Lehtonen S, Lehenkari P, Carlberg C, Saarnio J, Sebert S, Hyppönen E, Järvelin M-R, Herzig K-H. 2012. Inhibition of cytokine secretion from adipocytes by 1,25-dihydroxyvitamin D3 via the NF-kappaB pathway. FASEB JOURNAL 26: 4400-4407. 2012
• Seuter S, Pehkonen P, Heikkinen S, Carlberg C. 2012. The gene for the transcription factor BHLHE40/DEC1/stra13 is a dynamically regulated primary target of the vitamin D receptor. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY online [Epub ahead of print]: -. 2012
• John E, Wienecke-Baldacchino A, Liivrand M, Heinäniemi M, Carlberg C, Sinkkonen L. 2012. Dataset integration identifies transcriptional regulation of microRNA genes by PPARgamma in differentiating mouse 3T3-L1 adipocytes. NUCLEIC ACIDS RESEARCH 40 10: 4446-4460. 2012
• Carlberg Carsten, Molnár Ferdinand, Mouriño Antonio. 2012. Vitamin D receptor ligands: the impact of crystal structures. EXPERT OPINION ON THERAPEUTIC PATENTS 22 4: 417-435. 2012
• Carlberg C. 2012. The need for education in personalized medicine. Personalized Medicine 9 2: 147-150. 2012
• Carlberg C, Seuter S, Heikkinen S. 2012. The First Genome-wide View of Vitamin D Receptor Locations and Their Mechanistic Implications. ANTICANCER RESEARCH 32 1: 271-282. 2012
• Carlberg Carsten, Molnár Ferdinand. 2012. Current status of vitamin D signaling and its therapeutic applications CURRENT TOPICS IN MEDICINAL CHEMISTRY 12 6: 528-547. 2012
• Kriebitzsch C, Verlinden L, Eelen G, van Schoor NM, Swart K, Lips P, Meyer MB, Pike JW, Boonen S, Carlberg C, Vitvitsky V, Bouillon R, Banerjee R, Verstuyf A. 2011. 1,25-Dihydroxyvitamin D(3) Influences Cellular Homocystine Levels in Murine Preosteoplastic MC3T3-E1 Cells by Directs Regulation of Cystathionine beta-Synthase JOURNAL OF BONE AND MINERAL RESEARCH 26 12: 2991-2000. 2011
• Väisänen Sami, Matilainen Juha, Carlberg Carsten. 2011. Dynamic nature of transcriptional regulation of nuclear receptor target genes in the context of chromatin organization. Dermato-Endocrinology 3 3: 1-5. 2011
• Malinen Marjo, Ryynänen Jussi, Heinniemi Merja, Sami Väisänen Sami, Carlberg Carsten. 2011. Cyclical regulation of the insulin-like growth factor binding protein 3 gene in response to 1alpha,25-dihydroxyvitamin D3. NUCLEIC ACIDS RESEARCH 39 2: 502-512. 2011
• Kansanen Emilia, Bonacci Gustavo, Schopfer Francisco J, Kuosmanen Suvi M, Tong Kit I, Leinonen Hanna, Woodcock Steven R, Yamamoto Masayuk, Carlberg Carsten, Ylä-Herttuala Seppo, Freeman Bruce A, Levonen Anna-Liisa. 2011. Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism. JOURNAL OF BIOLOGICAL CHEMISTRY 286: 14019-14027. 2011
• Heikkinen Sami, Väisänen Sami, Pehkonen Petri, Seuter Sabine, Benes Vladimir, Carlberg Carsten. 2011. Nuclear hormone 1α,25-dihydroxyvitamin D3 elicits a genome-wide shift in the locations of VDR chromatin occupancy. NUCLEIC ACIDS RESEARCH 39 21: 9181-9193. 2011
• Gynther Petra, Toropainen Sari, Matilainen Juha M, Seuter Sabine, Carlberg Carsten, Väisänen Sami. 2011. Mechanism of 1α,25-dihydroxyvitamin D3-dependent repression of interleukin-12B. BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR CELL RESEARCH 1813 5: 810-818. 2011
• Carlberg Carsten. 2011. Target genes of vitamin D: Spatio-temporal interaction of chromatin, VDR and response elements: Feldman David, Pike J. Wesley, Adams John S., Vitamin D, Third Edition. 211-226. 2011
• Lahnalampi Mari, Heinäniemi Merja, Sinkkonen Lasse, Wabitsch Martin, Carlberg Carsten. 2010. Time-resolved expression profiling of the nuclear receptor superfamily in human adipogenesis. PLOS ONE [ONLINE] 5 9: -. 2010
• Venäläinen, T., Molnár, F., Oostenbrink, C., Carlberg, C. and Peräkylä M.. 2010. Molecular Mechanism of Allosteric Communication in the human PPAR alpha -RXR alpha Heterodimer. PROTEINS: STRUCTURE, FUNCTION, AND BIOINFORMATICS 78: 873-887. 2010
• Sari Toropainen, Sami Väisänen, Sami Heikkinen,Carsten Carlberg. 2010. The Down-regulation of the Human MYC Gene by the Nuclear Hormone 1α,25-dihydroxyvitamin D3 is Associated with Cycling of Corepressors and Histone Deacetylases. JOURNAL OF MOLECULAR BIOLOGY 400 3: 284-294. 2010
• Matilainen JM, Malinen M, Turunen MM, Carlberg C, Väisänen S. 2010. The number of vitamin D receptor binding sites defines the different vitamin D responsiveness of the CYP24 gene in malignant and normal mammary cells.. JOURNAL OF BIOLOGICAL CHEMISTRY 285 31: 24174-24183. 2010
• Matilainen JM, Husso T, Toropainen S, Seuter S, Turunen MP, Gynther P, Ylä-Herttuala S, Carlberg C, Väisänen S.. 2010. Primary effect of 1α,25(OH)(2)D(3) on IL-10 expression in monocytes is short-term down-regulation. BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR CELL RESEARCH 1803 11: 1276-1286. 2010
• Lou, Y-R., Molnár, F., Peräkylä, M., Qiao, S., Kalueff, A.V., St-Arnaud, R., Carlberg, C. and Tuohimaa, P.. 2010. 25-Hydroxyvitamin D3 is an Agonistic Vitamin D Receptor Ligand. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 118: 162-170. 2010
• Kolodkin AN, Frank J, Bruggeman FJ, Plant N, Moné MJ, Bakker B, Campbell MJ, van Leeuwen JPTM, Carlberg C, Snoep JL, Westerhoff HV. 2010. Design principles of nuclear receptor signaling: how complex networking improves signal transduction. MOLECULAR SYSTEMS BIOLOGY (ONLINE) 6: -. 2010
• Carlberg, Carsten, Heinäniemi Merja. 2010. The impact of whole genome in silico screening for nuclear receptor binding sites in systems biology: Lodhi Huma M, Muggleton Stephen H (editors), Elements of Computational Systems Biology.Wiley. 309-324. 2010
• Carlberg Carsten. 2010. The impact of transcriptional cycling on gene regulation. Transcription 1: 13-16. 2010
• Carlberg Carsten. 2010. New Insights to nuclear receptor gene regulation from analysis of their response elements in target genes. In: Bunce CM, Campbell MJ (editors) (ed.) , Nuclear Receptors, Proteins and Cell Regulation.Springer. ss. 419-437. 2010
• Carlberg Carsten. 2010. Diversity of vitamin D target genes: Holick MF (ed), Nutrition and Health: Vitamin D, 2nd Edition.Humana Press. 255-274. 2010
• Carlberg Carsten, Seuter Sabine. 2010. Dynamics of nuclear receptor target gene regulation. CHROMOSOMA 119 5: 479-484. 2010
• Makkonen KM, Malinen M, Ropponen A, Väisänen S, Carlberg C. 2009. Cell cycle regulatory effects of retinoid acid and forskolin are mediated by the Cyclin C gene. JOURNAL OF MOLECULAR BIOLOGY 393: 261-271. 2009
• Saramäki A, Diermeier S, Kellner R, Laitinen H, Väisänen S, Carlberg C. 2009. Cyclical chromatin looping and transcription factor association on the regulatory regions of the p21 (CDKN1A) gene in response to 1[alpha],25-dihydroxyvitamin D3. JOURNAL OF BIOLOGICAL CHEMISTRY 284 12: 8073-8082. 2009
• Makkonen KM, Pasonen-Seppänen S, Törrönen K, Tammi MI, Carlberg C. 2009. Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element-binding protein and retinoid acid receptor signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 284 27: 18270-18281. 2009
• Degenhardt T, Väisänen S, Rakhshandehroo M, Kersten S, Carlberg C. 2009. Peroxisome proliferator-activated receptor [alpha] controls hepatic heme biosynthesis throught ALAS1 JOURNAL OF MOLECULAR BIOLOGY 388: 225-238. 2009
• Degenhardt T, Rybakova KN, Tomaszewska A, Moné MJ, Westerhoff HV, Bruggeman FJ, Carlberg C. 2009. Population-level transcription cycles derive from stochastic timing of single-cell transcription. CELL 138: 489-501. 2009
• Carlberg C, Seuter S. 2009. A genomic perspective on vitamin D signaling. ANTICANCER RESEARCH 29: 3485-3494. 2009
• Campbell MJ, Carlberg C, Koeffler HP. 2008. A role for the PPARgamma in cancer therapy. PPAR RESEARCH [ONLINE] 314974: 17 s. 2008
• Heinäniemi M, Carlberg C. 2008. Screening for PPAR responsive regulatory modules in cancer. PPAR RESEARCH [ONLINE] 2008 749073: 8 s. 2008
• Mager U, Degenhardt T, Pulkkinen L, Kolehmainen M, Tolppanen A-M, Lindström J, Eriksson JG, Carlberg, Tuomilehto J, Uusitupa M, for the Finnish Diabetes Prevention Study Group. 2008. Variations in the ghrelin receptor gene associate with obesity and glucose metabolism in individuals with impaired glucose tolerance PLOS ONE [ONLINE] 3 8: e2941. 2008
• Malinen M, Saramäki A, Ropponen A, Degenhardt T, Väisänen S, Carlberg C. 2008. Distinct HDACs regulate the transcriptional response of human cyclin-dependent kinase inhibitor genes to trichostatin A and 1alpha,25-dihydroxyvitamin D3. NUCLEIC ACIDS RESEARCH 36 1: 121-132. 2008
• Pendás-Franco N, García JM, Peña C, Valle N, Pálmer HG, Heinäniemi M, Carlberg C, Jiménez B, Bonilla F, Muñoz A, González-Sancho JM. 2008. DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3. ONCOGENE (LONDON) 27: 4467-4477. 2008
• Reichrath J, Lehmann B, Carlberg C, Varani J, Zouboulis CC. 2007. Vitamins as hormones. HORMONE AND METABOLIC RESEARCH 39: 71-84. 2007
• Seuter S, Väisänen S, Rådmark O, Carlberg C, Steinhilber D. 2007. Functional characterization of vitamin D responding regions in the human 5-lipoxygenase gene. BIOCHIMICA ET BIOPHYSICA ACTA 1771: 864-872. 2007
• Saavalainen K, Tammi MI, Bowen T, Lienhard Schmitz M, Carlberg C. 2007. Integration of the activation of the human hyaluronan synthase 2 gene promoter by common cofactors of the transcription factors retinoic acid receptor and nuclear factor kappaB. JOURNAL OF BIOLOGICAL CHEMISTRY 282 15: 11530-11539. 2007
• Turunen MM, Dunlop TW, Carlberg C, Väisänen S. 2007. Selective use of multiple vitamin D response elements underlies the 1alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene. NUCLEIC ACIDS RESEARCH 35 8: 2734-2747. 2007
• Lee SS, Crabb SJ, Janghra N, Carlberg C, Williams AC, Cutress RI, Packham G, Hague A. 2007. Subcellular localisation of BAG-1 and its regulation of vitamin D receptor-mediated transactivation and involucrin expression in oral keratinocytes: implications for oral carcinogenesis. EXPERIMENTAL CELL RESEARCH 313: 3222-3238. 2007
• Degenhardt T, Saramäki A, Malinen M, Rieck M, Väisänen S, Huotari A, Herzig K-H, Müller R, Carlberg C. 2007. Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta. JOURNAL OF MOLECULAR BIOLOGY 372 2: 341-355. 2007
• Carlberg C, Seuter S. 2007. The vitamin D receptor. DERMATOLOGIC CLINICS 25: 515-523. 2007
• Carlberg C, Dunlop TW, Saramäki A, Sinkkonen L, Matilainen M, Väisänen S. 2007. Controlling the chromatin organization of vitamin D target genes by multiple vitamin D receptor binding sites. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 103: 338-343. 2007
• Heinäniemi M, Uski JO, Degenhardt T, Carlberg C. 2007. Meta-analysis of primary target genes of peroxisome proliferator-activated receptors GENOME BIOLOGY [ONLINE] 8: R147. 2007
• Molnár F, Peräkylä M, Carlberg C. 2006. Vitamin D receptor agonists specifically modulate the volume of the ligand-binding pocket JOURNAL OF BIOLOGICAL CHEMISTRY 281 15: 10516-10526. 2006
• Sorg BL, Klan N, Seuter S, Dishart D, Rådmark O, Habenicht A, Carlberg C, Werz O, Steinhilber D. 2006. Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site. BIOCHIMICA ET BIOPHYSICA ACTA 1761: 686-697. 2006
• Saramäki A, Banwell CM, Campbell MJ, Carlberg C. 2006. Regulation of the human p21(waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor. NUCLEIC ACIDS RESEARCH 34 2: 543-554. 2006
• Molnar Ferdinand, Peräkylä Mikael, Carlberg Carsten. 2006. Vitamin D Receptor Agonists Specifically Modulate the Volume of the Ligand-Binding Pocket JOURNAL OF BIOLOGICAL CHEMISTRY 281 15: 10516-10526. 2006
• Degenhardt T, Matilainen M, Herzig K-H, Dunlop TW, Carlberg C. 2006. The insulin-like growth factor-binding protein 1 gene is a primary target of peroxisome proliferator-activated receptors. JOURNAL OF BIOLOGICAL CHEMISTRY 281 51: 39607-39619. 2006
• Carlberg C, Molnar F. 2006. Detailed molecular understanding of agonistic and antagonistic vitamin D receptor ligands. CURRENT TOPICS IN MEDICINAL CHEMISTRY 6 12: 1243-53. 2006
• Carlberg C, Dunlop TW. 2006. The impact of chromatin organization of vitamin D target genes. ANTICANCER RESEARCH 26: 2637-2646. 2006
• Carlberg C, Dunlop TW. 2006. An integrated biological approach to nuclear receptor signaling in physiological control and disease. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION 16 1: 1-22. 2006
• Abedin SA, Banwell CM, Colston KW, Carlberg C, Campbell MJ. 2006. Epigenetic corruption of VDR signalling in malignancy ANTICANCER RESEARCH 26: 2557-2566. 2006
• Molnár F, Matilainen M, Carlberg C. 2005. Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators. JOURNAL OF BIOLOGICAL CHEMISTRY 280 28: 26543-26556. 2005
• Sinkkonen L, Malinen M, Saavalainen K, Väisänen S, Carlberg C. 2005. Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter NUCLEIC ACIDS RESEARCH 33 8: 2440-2451. 2005
• Saavalainen K, Pasonen-Seppänen S, Dunlop TW, Tammi R, Tammi MI, Carlberg C. 2005. The human hyaluronan synthase 2 gene is a primary retinoic acid and epidermal growth factor responding gene. JOURNAL OF BIOLOGICAL CHEMISTRY 280 15: 14636-14644. 2005
• Peräkylä M, Malinen M, Herzig K-H, Carlberg C. 2005. Gene regulatory potential of nonsteroidal vitamin D receptor ligands. MOLECULAR ENDOCRINOLOGY 19 8: 2060-2073. 2005
• Väisänen S, Dunlop TW, Sinkkonen L, Frank C, Carlberg C. 2005. Spatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1[alpha],25-dihydroxyvitamin D3. JOURNAL OF MOLECULAR BIOLOGY 350: 65-77. 2005
• Matilainen M, Malinen M, Saavalainen K, Carlberg C. 2005. Regulation of multiple insulin-like growth factor binding protein genes by 1[alpha],25-dihydroxyvitamin D3. NUCLEIC ACIDS RESEARCH 33 17: 5521-5532. 2005
• Kobayashi H, Kromminga A, Dunlop TW, Tychsen B, Conrad F, Suzuki N, Memezava A, Bettermann A, Aiba S, Carlberg C, Paus R. 2005. A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors. FASEB JOURNAL 19 12: 1710-1712. 2005
• Frank C, Makkonen H, Dunlop TW, Matilainen M, Väisänen S, Carlberg C. 2005. Identification of pregnane X reseptor binding sites in the regulatory regions of genes involved in bile acid homeostasis JOURNAL OF MOLECULAR BIOLOGY 346: 506-519. 2005
• Dunlop T, Väisänen S, Frank C, Molnár F, Sinkkonen L, Carlberg C. 2005. The human peroxisome proliferator-activated receptor [delta] gene is a primary target of 1[alpha],25-dihydroxyvitamin D3 and its nuclear receptor JOURNAL OF MOLECULAR BIOLOGY 349: 248-260. 2005
• Carlberg C, Dunlop TW, Frank C, Väisänen S. 2005. Molecular basis of the diversity of vitamin D target genes: Feldman D, Wesley Pike J, Glorieux FH, Vitamin D.Elsevier Academic Press. 313-325. 2005
• Lempiäinen H, Molnár F, Macias Gonzalez M, Peräkylä M, Carlberg C. 2005. Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein. MOLECULAR ENDOCRINOLOGY 19 9: 2258-2272. 2005
• Carlberg C. 2004. Ligand-mediated conformational changes of the VDR are required for gene transactivation JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 89-90: 227-232. 2004
• Carlberg C. 2004. Principles of gene regulation by bioactive lipids through members of the nuclear receptor family: Schmitz ML, Bacher S, Mechanisms of Signal Transduction and Inducible Gene Expression.Research signpost. 77-95. 2004
• Dunlop TW, Väisänen S, Frank C, Carlberg C. 2004. The genes of the coactivator TIF2 and the corepressor SMRT are primary 1alfa,25(OH)2D3 targets. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 89-90: 257-260. 2004
• Frank C, Molnar F, Matilainen M, Lempiäinen H, Carlberg C. 2004. Agonist-dependent and agonist-independent transactivations of the human constitutive androstane receptor are modulated by specific amino acid pairs. JOURNAL OF BIOLOGICAL CHEMISTRY 279 32: 33558-33566. 2004
• Moehren U, Dressel U, Reeb CA, Väisänen S, Dunlop TW, Carlberg C, Baniahmad A. 2004. The highly conserved region of the co-repressor Sin3A functionally interacts with the co-repressor alien NUCLEIC ACIDS RESEARCH 32 10: 2995-3004. 2004
• Peräkylä M, Molnar F, Carlberg C. 2004. A structural basis for the species-specific antagonism of 26,23-lactones on vitamin D signaling. CHEMISTRY AND BIOLOGY 11: 1147-1156. 2004
• Väisänen S, Dunlop TW, Frank C, Carlberg C. 2004. Using chromatin immunoprecipitation to monitor 1alfa,25-dihydroxyvitamin D3-dependent chromatin activity on the human CYP24 promoter. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 89-90: 277-279. 2004
• Frank C, Macias Gonzalez M, Oinonen C, Dunlop TW, Carlberg C. 2003. Characterization of DNA complexes formed by the nuclear receptor constitutive androstane receptor JOURNAL OF BIOLOGICAL CHEMISTRY 278 44: 43299-43310. 2003
• Väisänen S, Peräkylä M, Kärkkäinen JI, Uskokovic MR, Carlberg C. 2003. Structural evaluation of the agonistic action of a vitamin D analog with two side chains binding to the nuclear vitamin D receptor. MOLECULAR PHARMACOLOGY 63 6: 1230-1237. 2003
• Macias Gonzalez M, Samenfeld P, Peräkylä M, Carlberg C. 2003. Corepressor excess shifts the two-side chain vitamin D analog gemini from an agonist to an inverse agonist of the vitamin D receptor. MOLECULAR ENDOCRINOLOGY 17 10: 2028-2038. 2003
• Carlberg C, Mourino A. 2003. New vitamin D receptor ligands EXPERT OPINION ON THERAPEUTIC PATENTS 13 6: 761-772. 2003
• Carlberg C. 2003. Molecular basis of the selective activity of vitamin D analogues. JOURNAL OF CELLULAR BIOCHEMISTRY 88: 274-281. 2003
• Carlberg C. 2003. Current understanding of the function of the nuclear vitamin D receptor in response to its natural and synthetic ligands: J Reichrath, M Friedrich, W Tilgen, Vitamin D Analogs in Cancer Prevention and Therapy.Springer-Verlag. Recent Results in Cancer Research. 29-42. 2003
• Andersin T, Väisänen S, Carlberg C. 2003. The critical role of carboxy-terminal amino acids in ligand-dependent and -independent transactivation of the constitutive androstane receptor MOLECULAR ENDOCRINOLOGY 17 2: 234-246. 2003
• Macias Gonzalez M, Carlberg C. 2002. Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors. JOURNAL OF BIOLOGICAL CHEMISTRY 277 21: 18501-18509. 2002
• Mäkinen J, Frank C, Jyrkkärinne J, Gynther J, Carlberg C, Honkakoski P. 2002. Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors. MOLECULAR PHARMACOLOGY 62 2: 366-378. 2002
• Quack M, Frank C, Carlberg C. 2002. Differential nuclear receptor signalling from DR4-type response elements. JOURNAL OF CELLULAR BIOCHEMISTRY 86: 601-612. 2002
• Toell A, Kröncke K-D, Kleinert H, Carlberg C. 2002. Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands. JOURNAL OF CELLULAR BIOCHEMISTRY 85: 72-82. 2002
• Väisänen S, Peräkylä M, Kärkkäinen JI, Steinmeyer A, Carlberg C. 2002. Critical role of helix 12 of the vitamin D3 receptor for the partial agonism of carboxylic ester antagonists. JOURNAL OF MOLECULAR BIOLOGY 315: 229-238. 2002
• Lampen A, Carlberg C, Nau H. 2001. Peroxisome proliferator-activated receptor delta is a specific sensor for teratogenic valproic acid derivatives. EUROPEAN JOURNAL OF PHARMACOLOGY 431: 25-33. 2001
• Mork Hansen C , Binderup L, Hamberg KJ, Carlberg C. 2001. Vitamin D and cancer: Effects of 1,25(OH)2D3 and its analogs on growth control and tumorigenesis. FRONTIERS IN BIOSCIENCE 6: d820-d848. 2001
• Quack M, Carlberg C. 2001. Single thyroid hormone receptor monomers are competent for co-activator-mediated transactivation. BIOCHEMICAL JOURNAL 360: 387-393. 2001
• Toell A, Macias Gonzalez M, Ruf D, Steinmeyer A, Ishizuka S, Carlberg C. 2001. Different molecular mechanisms of vitamin D3 receptor antagonists MOLECULAR PHARMACOLOGY 59 6: 1478-1485. 2001