
Eva Maria del Amo Páez
Senior Researcher
My main interest is in intravitreal pharmacokinetics and pharmacodynamics of biologicals for the treatment of wet Age-related macular degeneration.
Docent in the field of pharmacokinetic modeling and simulations from 1.09.2021
School of Pharmacy, Faculty of Health Sciences
eva.delamo@uef.fi | +358 40 355 3883
Eva Maria del Amo, received her Ph.D. from the University of Helsinki with her dissertation “Ocular and Systemic Pharmacokinetic Models for Drug Discovery and Development” in 2015, and continued her research at the University of Eastern Finland, Kuopio in the ocular drug delivery research group under prof. Arto Urtti’s supervision. In 2018, she moved to Manchester where she started a Marie-Curie fellowship (Horizon 2020, https://cordis.europa.eu/project/id/799880) at the Centre for Applied Pharmacokinetic Research, at the University of Manchester. Her research focused on Pharmacokinetic-Pharmacodynamic models for patients with neovascular age-macular degeneration with anti-VEGF treatment, under the mentorship of prof. Leon Aarons and in collaboration with prof. Paul Bishop. In 2020, she returned to the University of Eastern Finland with the Orion Research Foundation grant to pursue her research interests on: the application of modeling and simulation techniques to characterize the pharmacokinetics and pharmacodynamics of ocular drugs, guide dosage selection, and improve drug treatment in patients with retinal diseases. Moreover, she is interested in drug binding to ocular melanin pigment to sustain therapy action. Apart from pharmacometrics, she is trained in Quantitative Structure Property Relationship (QSPR) and chemoinformatics.Her computational models to describe and predict intravitreal pharmacokinetic in rabbits and humans have been followed and utilized by several small and big pharmaceutical companies as well as in Academia.
Currently, Eva Maria del Amo is a docent in the field of pharmacokinetic modeling and simulations, and research Fellow in the research community Drug Discovery and Delivery Technologies at the University of Eastern Finland. She has published more than 40 publications including peer reviewed scientific articles and book chapters that have received >2200 citations (h-index 20). She has supervised five PhD students from Finland, UK, and USA (two graduated), and five MSc and Bachelor students (three graduated). She is a reviewer for journals such as Int J Pharm, Mol Pharm, Expert Opin Drug Deliv, Eur J Pharm Biopharm, Commun BioL and Drug Deliv Transl Res.
Research groups
Publications
47 items-
Mass spectrometry in ocular drug research
del Amo, Eva M.; Vellonen, Kati‐Sisko; Urtti, Arto; Terasaki, Tetsuya; Hammid, Anam; Honkakoski, Paavo; Auriola, Seppo. 2023. Mass spectrometry reviews. [First published: 02 August 2023]: 1-32 -
Topical pharmacokinetics of brinzolamide suspensions in rabbits and variability analysis for sample size and design considerations
Naageshwaran, Vatsala; Bigonne, Hélène; Gum, Glenwood; Malla, Spundana; del Sol, Charity; Bon, Charles; Xu, Xiaoming; Vo, Anh; Smith, William; O'Reilly Beringhs, Andre; Kozak, Darby; Tan, Ming Liang; Babiskin, Andrew; Urtti, Arto; del Amo, Eva M.; Ranta, Veli Pekka. 2023. International journal of pharmaceutics. 642: . 123183 -
Towards a population pharmacokinetic/pharmacodynamic model of anti-VEGF therapy in patients with age-related macular degeneration
del Amo, Eva M; Bishop, Paul N; Godia, Pere; Aarons, Leon. 2023. European journal of pharmaceutics and biopharmaceutics. 188: 78-88 -
Comments on “Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials”
del Amo, Eva M; Urtti, Arto; Ranta, Veli-Pekka. 2022. Journal of pharmacology and experimental therapeutics. 383: 246-247 -
Liposomal sunitinib for ocular drug delivery: A potential treatment for choroidal neovascularization
Tavakoli, Shirin; Puranen, Jooseppi; Bahrpeyma, Sina; Lautala, Veera E.; Karumo, Suvi; Lajunen, Tatu; del Amo, Eva M.; Ruponen, Marika; Urtti, Arto. 2022. International journal of pharmaceutics. 620: -
Mechanisms of cellular retention of melanin bound drugs: Experiments and computational modeling
Bahrpeyma, Sina; Reinisalo, Mika; Hellinen, Laura; Auriola, Seppo; del Amo, Eva M; Urtti, Arto. 2022. Journal of controlled release. 348: 760-770 -
Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations
del Amo, Eva M.; Hammid, Anam; Tausch, Melanie; Toropainen, Elisa; Sadeghi, Amir; Valtari, Annika; Puranen, Jooseppi; Reinisalo, Mika; Ruponen, Marika; Urtti, Arto; Sauer, Achim; Honkakoski, Paavo. 2022. International journal of pharmaceutics. 613: -
Pharmacokinetic Models: Indispensable Tools for Ophthalmic Drug Development
Del Amo, Eva M. 2022. ONdrugDelivery. 2022: 59-63 -
Topical ophthalmic administration: Can a drug instilled onto the ocular surface exert an effect at the back of the eye?
del Amo, Eva M.. 2022. Frontiers in drug delivery. 2: . 954771 -
Topical pharmacokinetics of dexamethasone suspensions in the rabbit eye: Bioavailability comparison
Naageshwaran, Vatsala; Ranta, Veli-Pekka; Toropainen, Elisa; Tuomainen, Marjo; Gum, Glenwood; Xie, Enli; Bhoopathy, Siddhartha; Urtti, Arto; del Amo, Eva M. 2022. International journal of pharmaceutics. 615: