Janne Tampio

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I study the applicability of transporter proteins in drug targeting. My research expertise includes e.g. cell culturing, in vitro studies and mass spectrometry (LC-MS).

Information Publications

Research groups

Transporter-Targeted Drug Delivery 01.09.2012 -

Keywords

analytical chemistry drug analysis drug delivery drug targeting drug transporters LC-MS mass spectrometry pharmaceutical chemistry pharmacokinetics pharmacy prodrug

Publications

12/12 items

Specific Transport of Temozolomide Does Not Override DNA Repair-mediated Chemoresistance
Bahrami, Katayan; Kärkkäinen, Jussi; Bibi, Sania; Huttunen, Johanna; Tampio, Janne; Montaser, Ahmed B.; Moody, Catherine L; Lehtonen, Marko; Rautio, Jarkko; Wheelhouse, Richard T; Huttunen, Kristiina M. 2024. European journal of pharmaceutical sciences. 195:
Amino acid derivative of probenecid potentiates apoptosis-inducing effects of vinblastine by increasing oxidative stress in a cancer cell-specific manner
Huttunen, Johanna; Tampio, Janne; Järvinen, Juulia; Montaser, Ahmed B; Markowicz-Piasecka, Magdalena; Huttunen, Kristiina M. 2023. Chemico-biological interactions. 2024; 388:
Metformin derivatives – Researchers’ friends or foes?
Torunoglu, Sema Tuna; Zajda, Agnieszka; Tampio, Janne; Markowicz-Piasecka, Magdalena; Huttunen, Kristiina M. 2023. Biochemical pharmacology. 215:
Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study
Lapatto, Helena A. K.; Kuusela, Minna; Heikkinen, Aino; Muniandy, Maheswary; van der Kolk, Birgitta W.; Gopalakrishnan, Swetha; Pöllänen, Noora; Sandvik, Martin; Schmidt, Mark S.; Heinonen, Sini; Saari, Sina; Kuula, Juho; Hakkarainen, Antti; Tampio, Janne; Saarinen, Tuure; Taskinen, Marja-Riitta; Lundbom, Nina; Groop, Per-Henrik; Tiirola, Marja; Katajisto, Pekka; Lehtonen, Marko; Brenner, Charles; Kaprio, Jaakko; Pekkala, Satu; Ollikainen, Miina; Pietiläinen, Kirsi H.; Pirinen, Eija. 2023. Science advances. 9: 1-23
Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon
Cui, Hengjing; Elford, Joshua D; Alitalo, Okko; Perez-Pardo, Paula; Tampio, Janne; Huttunen, Kristiina M; Kraneveld, Aletta; Forsberg, Markus M; Myöhänen, Timo T; Jalkanen, Aaro J. 2023. Neurobiology of aging. 129: 62-71
Substituent effects of sulfonamide derivatives of metformin that can dually improve cellular glucose utilization and anti-coagulation
Zajda, Agnieszka; Sikora, Joanna; Hynninen, Mira; Tampio, Janne; Huttunen, Kristiina M.; Markowicz-Piasecka, Magdalena. 2023. Chemico-biological interactions. 373:
Targeting Glial Cells by Organic Anion-Transporting Polypeptide 1C1 (OATP1C1)-Utilizing l-Thyroxine-Derived Prodrugs
Tonduru, Arun Kumar; Maljaei, Seyed Hamed; Adla, Santosh Kumar; Anamea, Landry; Tampio, Janne; Králová, Adéla; Jalkanen, Aaro J; Espada, Catarina; Santos, Inês Falcato; Montaser, Ahmed B; Rautio, Jarkko; Kronenberger, Thales; Poso, Antti; Huttunen, Kristiina M. 2023. Journal of medicinal chemistry. 66: 15094-15114
Comparison of Experimental Strategies to Study l-Type Amino Acid Transporter 1 (LAT1) Utilization by Ligands
Huttunen, Johanna; Agami, Mahmoud; Tampio, Janne; Montaser, Ahmed B; Huttunen, Kristiina M. 2022. Molecules. 27:
L-type Amino Acid Transporter 1 Utilizing Ferulic Acid Derivatives Show Increased Drug Delivery in the Mouse Pancreas Along with Decreased Lipid Peroxidation and Prostaglandin Production
Tampio, Janne; Markowicz-Piasecka, Magdalena; Montaser, Ahmed; Rysä, Jaana; Kauppinen, Anu; Huttunen, Kristiina M. 2022. Molecular pharmaceutics. 19: 380-3819
Hemocompatible L-Type amino acid transporter 1 (LAT1)-Utilizing prodrugs of perforin inhibitors can accumulate into the pancreas and alleviate inflammation-induced apoptosis
Tampio, Janne; Markowicz-Piasecka, Magdalena; Huttunen, Kristiina M.. 2021. Chemico-biological interactions. 345: 109560
Improved L-Type Amino Acid Transporter 1 (LAT1)-Mediated Delivery of Anti-Inflammatory Drugs into Astrocytes and Microglia with Reduced Prostaglandin Production
Tampio, Janne; Löffler, Susanne; Guillon, Melina; Hugele, Agathe; Huttunen, Johanna; Huttunen, Kristiina M.. 2021. International journal of pharmaceutics. 601: 120565
Targeting of Perforin Inhibitor into the Brain Parenchyma Via a Prodrug Approach Can Decrease Oxidative Stress and Neuroinflammation and Improve Cell Survival
Tampio, Janne; Huttunen, Johanna; Montaser, Ahmed; Huttunen, Kristiina M. 2020. Molecular neurobiology. 57: 4563-4577

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Research groups

Keywords

Specific Transport of Temozolomide Does Not Override DNA Repair-mediated Chemoresistance

Amino acid derivative of probenecid potentiates apoptosis-inducing effects of vinblastine by increasing oxidative stress in a cancer cell-specific manner

Metformin derivatives – Researchers’ friends or foes?

Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study

Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon

Substituent effects of sulfonamide derivatives of metformin that can dually improve cellular glucose utilization and anti-coagulation

Targeting Glial Cells by Organic Anion-Transporting Polypeptide 1C1 (OATP1C1)-Utilizing l-Thyroxine-Derived Prodrugs

Comparison of Experimental Strategies to Study l-Type Amino Acid Transporter 1 (LAT1) Utilization by Ligands

L-type Amino Acid Transporter 1 Utilizing Ferulic Acid Derivatives Show Increased Drug Delivery in the Mouse Pancreas Along with Decreased Lipid Peroxidation and Prostaglandin Production

Hemocompatible L-Type amino acid transporter 1 (LAT1)-Utilizing prodrugs of perforin inhibitors can accumulate into the pancreas and alleviate inflammation-induced apoptosis

Improved L-Type Amino Acid Transporter 1 (LAT1)-Mediated Delivery of Anti-Inflammatory Drugs into Astrocytes and Microglia with Reduced Prostaglandin Production

Targeting of Perforin Inhibitor into the Brain Parenchyma Via a Prodrug Approach Can Decrease Oxidative Stress and Neuroinflammation and Improve Cell Survival