Janne Tampio - UEFConnect

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Information Publications

Research groups

Transporter-Targeted Drug Delivery 01.09.2012 -

Keywords

analytical chemistry drug analysis drug delivery drug targeting drug transporters LC-MS mass spectrometry pharmaceutical chemistry pharmacokinetics pharmacy prodrug

Publications

17/17 items

A novel paracetamol derivative alleviates lipopolysaccharide-induced neuroinflammation
Králová, Adéla; Montaser, Ahmed B; Tampio, Janne; Adla, Santosh Kumar; Jalkanen, Aaro; Rysä, Jaana; Huttunen, Kristiina M, 2025, European journal of pharmacology, 995, 177409. A1 Journal article (refereed), original research
Amino acid prodrug of capsaicin improves pharmacokinetic properties in the mouse brain and pancreas
Tampio, Janne; Králová, Adéla; Riihioja, Sara; Pitkänen, Sofia; Markowicz-Piasecka, Magdalena; Ihamäki, Olli; Savolainen, Katja; Torunoglu, Sema T; Jalkanen, Aaro J; Lehtonen, Marko; Kauppinen, Anu; Rysä, Jaana; Huttunen, Kristiina M, 2025, European journal of pharmaceutics and biopharmaceutics, 214, 114797. A1 Journal article (refereed), original research
Lääkeaineiden "perillesaannin" haasteet ja ratkaisut
Tampio, Janne; Huttunen, Kristiina M., 2025, Tieteessä tapahtuu, 43, 4, 6-11. E1 Popularised article, newspaper article
Asymmetric Synthesis and Biological Evaluation of Both Enantiomers of 5- and 6-Boronotryptophan as Potential Boron Delivery Agents for Boron Neutron Capture Therapy
Retini, Michele; Järvinen, Juulia; Bahrami, Katayun; Tampio, Janne; Bartoccini, Francesca; Riihelä, Petri; Pehkonen, Henna; Värä, Arina; Laitinen, Tuomo; Huttunen, Kristiina M.; Rautio, Jarkko; Piersanti, Giovanni; Timonen, Juri M, 2024, Acs medicinal chemistry letters, 15, 12, 2121-2128. A1 Journal article (refereed), original research
Specific Transport of Temozolomide Does Not Override DNA Repair-mediated Chemoresistance
Bahrami, Katayan; Kärkkäinen, Jussi; Bibi, Sania; Huttunen, Johanna; Tampio, Janne; Montaser, Ahmed B.; Moody, Catherine L; Lehtonen, Marko; Rautio, Jarkko; Wheelhouse, Richard T; Huttunen, Kristiina M, 2024, European journal of pharmaceutical sciences, 195, 106661. A1 Journal article (refereed), original research
The L-type amino acid transporter 1 enhances drug delivery to the mouse pancreatic beta cell line (MIN6)
Tampio, Janne; Montaser, Ahmed B.; Järvinen, Juulia; Lehtonen, Marko; Jalkanen, Aaro J.; Reinisalo, Mika; Kokkola, Tarja; Terasaki, Tetsuya; Laakso, Markku; Rysä, Jaana; Kauppinen, Anu; Huttunen, Kristiina M, 2024, European journal of pharmaceutical sciences, 203, 106937. A1 Journal article (refereed), original research
Amino acid derivative of probenecid potentiates apoptosis-inducing effects of vinblastine by increasing oxidative stress in a cancer cell-specific manner
Huttunen, Johanna; Tampio, Janne; Järvinen, Juulia; Montaser, Ahmed B; Markowicz-Piasecka, Magdalena; Huttunen, Kristiina M, 2023, Chemico-biological interactions, 2024; 388, 110833. A1 Journal article (refereed), original research
Metformin derivatives – Researchers’ friends or foes?
Torunoglu, Sema Tuna; Zajda, Agnieszka; Tampio, Janne; Markowicz-Piasecka, Magdalena; Huttunen, Kristiina M, 2023, Biochemical pharmacology, 215, 115743. A2 Review article, Literature review, Systematic review
Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study
Lapatto, Helena A. K.; Kuusela, Minna; Heikkinen, Aino; Muniandy, Maheswary; van der Kolk, Birgitta W.; Gopalakrishnan, Swetha; Pöllänen, Noora; Sandvik, Martin; Schmidt, Mark S.; Heinonen, Sini; Saari, Sina; Kuula, Juho; Hakkarainen, Antti; Tampio, Janne; Saarinen, Tuure; Taskinen, Marja-Riitta; Lundbom, Nina; Groop, Per-Henrik; Tiirola, Marja; Katajisto, Pekka; Lehtonen, Marko; Brenner, Charles; Kaprio, Jaakko; Pekkala, Satu; Ollikainen, Miina; Pietiläinen, Kirsi H.; Pirinen, Eija, 2023, Science advances, 9, 2, 1-23. A1 Journal article (refereed), original research
Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon
Cui, Hengjing; Elford, Joshua D; Alitalo, Okko; Perez-Pardo, Paula; Tampio, Janne; Huttunen, Kristiina M; Kraneveld, Aletta; Forsberg, Markus M; Myöhänen, Timo T; Jalkanen, Aaro J, 2023, Neurobiology of aging, 129, 62-71. A1 Journal article (refereed), original research
Substituent effects of sulfonamide derivatives of metformin that can dually improve cellular glucose utilization and anti-coagulation
Zajda, Agnieszka; Sikora, Joanna; Hynninen, Mira; Tampio, Janne; Huttunen, Kristiina M.; Markowicz-Piasecka, Magdalena, 2023, Chemico-biological interactions, 373, 110381. A1 Journal article (refereed), original research
Targeting Glial Cells by Organic Anion-Transporting Polypeptide 1C1 (OATP1C1)-Utilizing l-Thyroxine-Derived Prodrugs
Tonduru, Arun Kumar; Maljaei, Seyed Hamed; Adla, Santosh Kumar; Anamea, Landry; Tampio, Janne; Králová, Adéla; Jalkanen, Aaro J; Espada, Catarina; Santos, Inês Falcato; Montaser, Ahmed B; Rautio, Jarkko; Kronenberger, Thales; Poso, Antti; Huttunen, Kristiina M, 2023, Journal of medicinal chemistry, 66, 22, 15094-15114. A1 Journal article (refereed), original research
Comparison of Experimental Strategies to Study l-Type Amino Acid Transporter 1 (LAT1) Utilization by Ligands
Huttunen, Johanna; Agami, Mahmoud; Tampio, Janne; Montaser, Ahmed B; Huttunen, Kristiina M, 2022, Molecules, 27, 1, 37. A1 Journal article (refereed), original research
L-type Amino Acid Transporter 1 Utilizing Ferulic Acid Derivatives Show Increased Drug Delivery in the Mouse Pancreas Along with Decreased Lipid Peroxidation and Prostaglandin Production
Tampio, Janne; Markowicz-Piasecka, Magdalena; Montaser, Ahmed; Rysä, Jaana; Kauppinen, Anu; Huttunen, Kristiina M, 2022, Molecular pharmaceutics, 19, 11, 3806-3819. A1 Journal article (refereed), original research
Hemocompatible L-Type amino acid transporter 1 (LAT1)-Utilizing prodrugs of perforin inhibitors can accumulate into the pancreas and alleviate inflammation-induced apoptosis
Tampio, Janne; Markowicz-Piasecka, Magdalena; Huttunen, Kristiina M., 2021, Chemico-biological interactions, 345, 109560. A1 Journal article (refereed), original research
Improved L-Type Amino Acid Transporter 1 (LAT1)-Mediated Delivery of Anti-Inflammatory Drugs into Astrocytes and Microglia with Reduced Prostaglandin Production
Tampio, Janne; Löffler, Susanne; Guillon, Melina; Hugele, Agathe; Huttunen, Johanna; Huttunen, Kristiina M., 2021, International journal of pharmaceutics, 601, 120565. A1 Journal article (refereed), original research
Targeting of Perforin Inhibitor into the Brain Parenchyma Via a Prodrug Approach Can Decrease Oxidative Stress and Neuroinflammation and Improve Cell Survival
Tampio, Janne; Huttunen, Johanna; Montaser, Ahmed; Huttunen, Kristiina M, 2020, Molecular neurobiology, 57, 11, 4563-4577. A1 Journal article (refereed), original research