Jarkko Ketolainen
Head of Department
Professor
Head of the Department
School of Pharmacy, Faculty of Health Sciences
jarkko.ketolainen@uef.fi | +358 40 355 2486
Research groups
Projects
Publications
157/157 items-
Continuous direct compression of a commercially batch-manufactured tablet formulation with two different processing lines
Lyytikäinen, Jenna; Stasiak, Pawel; Kubelka, Tomáš; Bogaerts, Ivan; Wanek, Adam; Stynen, Bart; Holman, James; Ketolainen, Jarkko; Ervasti, Tuomas; Korhonen, Ossi. 2024. European journal of pharmaceutics and biopharmaceutics. 199: -
Challenges encountered in the transfer of atorvastatin tablet manufacturing - commercial batch-based production as a basis for small-scale continuous tablet manufacturing tests
Lyytikäinen, Jenna; Kyllönen, Saini; Ervasti, Tuomas; Komulainen, Eelis; Pekarek, Tomáš; Slunečková, Jitka; Leskinen, Jari; Ketolainen, Jarkko; Kubelka, Tomáš; Stasiak, Pawel; Korhonen, Ossi. 2023. International journal of pharmaceutics. 647: . 123509 -
Flowsheet modelling of a powder continuous feeder-mixer system
Dias, Rute C; Korhonen, Ossi; Ketolainen, Jarkko; Lopes, João A; Ervasti, Tuomas. 2023. International journal of pharmaceutics. 639: -
High-speed optical observations of asymmetric pulsations of microbubbles released from tablet matrix
Carlson, Craig S; Anderton, Nicole; Xinyue, Hu; Otake, Naoyuki; Kudo, Nobuki; Sorjonen, Joona; Ketolainen, Jarkko; Postema, Michiel. 2023. Current directions in biomedical engineering. 9: 25-28 -
Värikäs viides vuosikymmen - laitosjohtajan katsaus
Ketolainen, Jarkko. 2023. Publications of the University of Eastern Finland. General series. 44: 15-17 -
Detecting different amorphous – amorphous phase separation patterns in co-amorphous mixtures with high resolution imaging FTIR spectroscopy
Kilpeläinen, Tuomas; Ervasti, Tuomas; Uurasjärvi, Emilia; Koistinen, Arto; Ketolainen, Jarkko; Korhonen, Ossi; Pajula, Katja. 2022. European journal of pharmaceutics and biopharmaceutics. 180: 161-169 -
Effect of shape on the physical properties of pharmaceutical tablets
Sultan, Tipu; Xu, Xiaochi; Hasan Rozin, Enamul; Sorjonen, Joona; Ketolainen, Jarkko; Wikström, Håkan; Martin de Juan, Luis; Tajarobi, Pirjo; Cetinkaya, Cetin. 2022. International journal of pharmaceutics. 624: -
Faster to First-time-in-Human: Prediction of the liquid solid ratio for continuous wet granulation
Junnila, Atte; Wikström, Håkan; Megarry, Andrew; Gholami, Aida; Papathanasiou, Foteini; Blomberg, Andreas; Ketolainen, Jarkko; Tajarobi, Pirjo. 2022. European journal of pharmaceutical sciences. 172: -
Parameter optimization in a continuous direct compression process of commercially batch-produced bisoprolol tablets
Lyytikäinen, Jenna; Stasiak, Pawel; Kubelka, Tomáš; Olenius, Tino; Korhonen, Ossi; Ketolainen, Jarkko; Ervasti, Tuomas. 2022. International journal of pharmaceutics. 628: -
Preparation and characterization of hot-melt extruded polycaprolactone-based filaments intended for 3D-printing of tablets
Viidik, Laura; Vesala, Jemina; Laitinen, Riikka; Korhonen, Ossi; Ketolainen, Jarkko; Aruväli, Jaan; Kirsimäe, Kalle; Kogermann, Karin; Heinämäki, Jyrki; Laidmäe, Ivo; Ervasti, Tuomas. 2021. European journal of pharmaceutical sciences. 158: 105619 -
Comparison between twin-screw and high-shear granulation - The effect of filler and active pharmaceutical ingredient on the granule and tablet properties
Kyttä, Kaisa M; Lakio, Satu; Wikström, Håkan; Sulemanji, Anisa; Fransson, Magnus; Ketolainen, Jarkko; Tajarobi, Pirjo. 2020. Powder technology. 376: 187-198 -
Converting a batch based high-shear granulation process to a continuous dry granulation process; a demonstration with ketoprofen tablets
Taipale-Kovalainen, Krista; Ketolainen, Jarkko; Korhonen, Ossi; Ervasti, Tuomas. 2020. European journal of pharmaceutical sciences. 151: 105381 -
Simultaneous Investigation of the Liquid Transport and Swelling Performance during Tablet Disintegration
Al-Sharabi, Mohammed; Markl, Daniel; Mudley, Theona; Bawuah, Prince; Karttunen, Anssi-Pekka; Ridgway, Cathy; Gane, Patrick; Ketolainen, Jarkko; Peiponen, Kai-Erik; Rades, Thomas; Zeitler, J. Axel. 2020. International journal of pharmaceutics. 584: 119380 -
The Comparison of Two Challenging Low Dose APIs in a Continuous Direct Compression Process
Ervasti, Tuomas; Niinikoski, Hannes;, Mäki-Lohiluoma, Eero; Leppinen, Heidi; Ketolainen, Jarkko; Korhonen, Ossi; Lakio, Satu. 2020. Pharmaceutics. 12: 279 -
Comparison between integrated continuous direct compression line and batch processing - The effect of raw material properties
Karttunen, AP; Wikström, H; Tajarobi, P; Fransson, M; Sparén, A; Marucci, M; Ketolainen, J; Folestad, S; Korhonen, O; Abrahmsén-Alami, S. 2019. European journal of pharmaceutical sciences. 133: 40-53 -
Measurement of residence time distributions and material tracking on three continuous manufacturing lines
Karttunen, AP; Hörmann, TR; De Leersnyder, F; Ketolainen, J; De Beer, T; Hsiao, WK; Korhonen, O. 2019. International journal of pharmaceutics. 563: 184-197 -
Investigating elastic relaxation effects on the optical properties of functionalised calcium carbonate compacts using optics-based Heckel analysis
Bawuah, Prince; Karttunen, Anssi-Pekka; Markl, Daniel; Ridgway, Cathy; Korhonen, Ossi; Gane, Patrick; Zeitler, J Axel; Ketolainen, Jarkko; Peiponen, Kai-Erik. 2018. International journal of pharmaceutics. 544: 278-284 -
RTD-based Material Tracking in a Fully-Continuous Dry Granulation Tableting Line
Martinetz, MC; Karttunen, AP; Sacher, S; Wahl, P; Ketolainen, J; Khinast, JG; Korhonen, O. 2018. International journal of pharmaceutics. 547: 469-479 -
Resolving the rapid water absorption of porous functionalised calcium carbonate powder compacts by terahertz pulsed imaging
Markl, Daniel; Wang, Parry; Ridgway, Cathy; Karttunen, Anssi-Pekka; Bawuah, Prince; Ketolainen, Jarkko; Gane, Patrick; Peiponen, Kai-Erik; Zeitler, J Axel. 2018. Chemical engineering research and design. 132: 1082-1090 -
Terahertz absorption spectra of commonly used antimalarial drugs
Bawuah, Prince; Zeitler, J Axel; Ketolainen, Jarkko; Peiponen Kai-Erik. 2018. Optical review. 25: 444-449 -
The effects of unintentional and intentional process disturbances on tablet quality during long continuous manufacturing runs
Taipale-Kovalainen, Krista; Karttunen, Anssi-Pekka; Niinikoski, Hannes; Ketolainen, Jarkko; Korhonen, Ossi. 2018. European journal of pharmaceutical sciences. 2019; 129: 10-20 -
Analysis of Anisotropic Pore Structures using Terahertz Spectroscopy and Imaging
Markl Daniel, Ridgway Cathy, Bawuah Prince, Gane Patrick, Ketolainen Jarkko, Peiponen Kai-Erik, Zeitler Axel. Teoksessa: -(toim.) , 2017. 42nd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz), 2017. s. -. -
Characterization of the Pore Structure of Functionalized Calcium Carbonate Tablets by Terahertz Time-Domain Spectroscopy and X-ray Computed Microtomography
Markl Daniel, Wang Parry, Ridgway Cathy, Karttunen Anssi-Pekka, Chakraborty Mousumi, Bawuah Prince, Pääkkönen Pertti, Gane Patrick, Ketolainen Jarkko, Peiponen Kai, Zeitler J Axel. 2017. Journal of pharmaceutical sciences. 106: 1586-1595 -
Effect of storage on the physical stability of thin polymethacrylate-perphenazine films
Korhonen Kristiina, Smolander Elina, Korhonen Ossi, Ketolainen Jarkko, Laitinen Riikka. 2017. European journal of pharmaceutical sciences. 104: 293-301 -
Efficient production of solid dispersions by spray drying solutions of high solid content using a 3-fluid nozzle
Kauppinen Ari, Broekhuis Joep, Grasmeijer Niels, Tonnis Wouter, Ketolainen Jarkko, Frijlink Henderik W, Hinrichs Wouter LJ. 2017. European journal of pharmaceutics and biopharmaceutics. 2018; 123: 50-58 -
Fast and non-destructive pore structure analysis using terahertz time-domain spectroscopy
Markl Daniel, Bawuah Prince, Ridgway Cathy, van den Ban Sander, Goodwin Daniel J, Ketolainen Jarkko, Gane Patrick, Peiponen Kai-Erik, Zeitler J.Axel. 2017. International journal of pharmaceutics. 2018; 537: 102-110 -
Lubricant based determination of design space for continuously manufactured high dose paracetamol tablets
Taipale-Kovalainen Krista, Karttunen Anssi-Pekka, Ketolainen Jarkko, Korhonen Ossi. 2017. European journal of pharmaceutical sciences. 2018; 115: 1-10 -
On the role of API in determining porosity, pore structure and bulk modulus of the skeletal material in pharmaceutical tablets formed with MCC as sole excipient
Ridgway Cathy, Bawuah Prince, Markl Daniel, Zeitler J Axel, Ketolainen Jarkko, Peiponen Kai-Erik, Gane Patrick. 2017. International journal of pharmaceutics. 526: 321-331 -
Optics-based compressibility parameter for pharmaceutical tablets obtained with the aid of the terahertz refractive index
Chakraborty Mousumi, Ridgway Cathy, Bawuah Prince, Markl Daniel, Gane Patrick AC, Ketolainen Jarkko, Zeitler J Axel, Peiponen Kai-Erik. 2017. International journal of pharmaceutics. 525: 85-91 -
Provoking an end-to-end continuous direct compression line with raw materials prone to segregation
Lakio S, Ervasti T, Tajarobi P, Wikström H, Fransson M, Karttunen AP, Ketolainen J, Folestad S, Abrahmsén-Alami S, Korhonen O. 2017. European journal of pharmaceutical sciences. 109: 514-524 -
Reflectometric monitoring of the dissolution process of thin polymeric films
Laitinen R, Räty J, Korhonen K, Ketolainen J, Peiponen K-E. 2017. International journal of pharmaceutics. 523: 127-132 -
A structure parameter for porous pharmaceutical tablets obtained with the aid of Wiener bounds for effective permittivity and terahertz time-delay measurement
Bawuah Prince, Chakraborty Mousumi, Ervasti Tuomas, Zeitler J Axel, Ketolainen Jarkko, Gane Patrick A C, Peiponen Kai-Erik. 2016. International journal of pharmaceutics. 506: 87-92 -
Achieving a robust drug release from extended release tablets using an integrated continuous mixing and direct compression line
Lakio Satu, Tajarobi Pirjo, Wikström Håkan, Fransson Magnus, Arnehed Johan, Ervasti Tuomas, Simonaho Simo-Pekka, Ketolainen Jarkko, Folestad Staffan, Abrahmsén-Alami Susanna. 2016. International journal of pharmaceutics. 511: 659-668 -
Continuous manufacturing of tablets with PROMIS-line - Introduction and case studies from continuous feeding, blending and tableting
Simonaho Simo-Pekka, Ketolainen Jarkko, Ervasti Tuomas, Toiviainen Maunu, Korhonen Ossi. 2016. European journal of pharmaceutical sciences. 90: 38-46 -
Effects of Cooling Rate in Microscale and Pilot Scale Freeze-Drying - Variations in Excipient Polymorphs and Protein Secondary Structure
Peters Björn-Hendrik, Staels Lotte, Rantanen Jimi, Molnár Ferdinand, De Beer Thomas, Lehto Vesa-Pekka, Ketolainen Jarkko. 2016. European journal of pharmaceutical sciences. 95: 72-81 -
Linking granulation performance with residence time and granulation liquid distributions in twin-screw granulation: An experimental investigation
Kumar Ashish, Alakarjula Maija, Vanhoorne Valérie, Toiviainen Maunu, De Leersnyder Fien, Vercruysse Jurgen, Juuti Mikko, Ketolainen Jarkko, Vervaet Chris, Remon Jean Paul, Gernaey Krist V, De Beer Thomas, Nopens Ingmar. 2016. European journal of pharmaceutical sciences. 90: 25-37 -
Noninvasive porosity measurement of biconvex tablets using terahertz pulses
Bawuah Prince, Ervasti Tuomas, Tan Nicholas, Zeitler J Axel, Ketolainen Jarkko, Peiponen Kai-Erik. 2016. International journal of pharmaceutics. 509: 439-443 -
On the Correlation of Effective Terahertz Refractive Index and Average Surface Roughness of Pharmaceutical Tablets
Chakraborty Mousumi, Bawuah Prince, Tan Nicholas, Ervasti Tuomas, Pääkkönen Pertti, Zeitler J Axel, Ketolainen Jarkko, Peiponen Kai-Erik. 2016. Journal of infrared, millimeter, and terahertz waves. First online: 14 March 2016: 1-10 -
Strategic framework for education and training in quality by design (QbD) and process analytical technology (PAT)
de Matas Marcel, De Beer Thomas, Folestad Staffan, Ketolainen Jarkko, Lindén Hans, Lopes João A, Oostra Wim, Weimer Marco, Ohrngren Per, Rantanen Jukka. 2016. European journal of pharmaceutical sciences. 90: 2-7 -
Systematic evaluation of a spraying method for preparing thin Eudragit-drug films by Design of Experiments
Korhonen Kristiina, Poikolainen Mirja, Korhonen Ossi, Ketolainen Jarkko, Laitinen Riikka. 2016. Journal of drug delivery science and technology. 35: 241-251 -
Terahertz study on porosity and mass fraction of active pharmaceutical ingredient of pharmaceutical tablets
Bawuah Prince, Tan Nicholas, Tweneboah Samuel Nana A., Ervasti Tuomas, Zeitler J Axel, Ketolainen Jarkko, Peiponen Kai-Erik. 2016. European journal of pharmaceutics and biopharmaceutics. 105: 122-133 -
Terahertz time-domain study on selected parameters of pharmaceutical tablets using effective medium approximations
Prince Bawuah, Mousumi Chakraborty, Tuomas Ervasti, J. Axel Zeitler, Jarkko Ketolainen, Kai-Erik Peiponen. 2016. Tampere university of technology -
A Quantitative study on the change of the effective refractive index of pharmaceutical tablets using terahertz-time-domain spectroscopy
Bawuah Prince, Ervasti Tuomas, Tan Nicholas, Ketolainen Jarkko, Zeitler J Axel, Peiponen Kai-Erik. 2015. UEF -
Comparison of a continuous ring layer wet granulation process with batch high shear and fluidized bed granulation processes
Järvinen Maiju A, Paavola Marko, Poutiainen Sami, Itkonen Päivi, Pasanen Ville, Uljas Katja, Leiviskä Kauko, Juuti Mikko, Ketolainen Jarkko, Järvinen Kristiina. 2015. Powder technology. 275: 113-120 -
Continuous manufacturing of extended release tablets via powder mixing and direct compression
Ervasti Tuomas, Simonaho Simo-Pekka, Ketolainen Jarkko, Forsberg Peter, Fransson Magnus, Wikström Håkan, Folestad Staffan, Lakio Satu, Tajarobi Pirjo, Abrahmsén-Alami Susanna. 2015. International journal of pharmaceutics. 495: 290-301 -
Estimation of Young's modulus of pharmaceutical tablet obtained by terahertz time-delay measurement
Peiponen Kai-Erik, Bawuah Prince, Chakraborty Mousumi, Juuti Mikko, Zeitler J Axel, Ketolainen Jarkko. 2015. International journal of pharmaceutics. 489: 100-105 -
Impact of Microscale and Pilot-Scale Freeze-Drying on Protein Secondary Structures: Sucrose Formulations of Lysozyme and Catalase
Peters Björn-Hendrik, Leskinen Jari T, Molnár Ferdinand, Ketolainen Jarkko. 2015. Journal of pharmaceutical sciences. 104: 3710-3721 -
Monitoring of Drug Release Kinetics from Thin Polymer Films by Multi-Parametric Surface Plasmon Resonance
Korhonen Kristiina, Granqvist Niko, Ketolainen Jarkko, Laitinen Riikka. 2015. International journal of pharmaceutics. 494: 531-536 -
Quality control of freeze-dried protein formulations using near-infrared imaging
Kauppinen Ari, Peters Björn-Hendrik, Toiviainen Maunu, Ketolainen Jarkko. 2015. EUFEPS -
Theophylline-nicotinamide cocrystal formation in physical mixture during storage
Ervasti Tuomas, Aaltonen Jaakko, Ketolainen Jarkko. 2015. International journal of pharmaceutics. 486: 121-130 -
Detection of porosity of pharmaceutical compacts by terahertz radiation transmission and light reflection measurement techniques
Bawuah Prince, Pierotic Mendia Alessandra, Silfsten Pertti, Pääkkönen Pertti, Ervasti Tuomas, Ketolainen Jarkko, Zeitler J. Axel, Peiponen Kai-Erik. 2014. International journal of pharmaceutics. Volume 465: 70-76 -
Influence of raw material properties upon critical quality attributes of continuously produced granules and tablets
Fonteyne Margot, Wickström Henrika, Peeters Elisabeth, Vercruysse Jurgen, Ehlers Henrik, Peters Björn-Hendrik, Remon Jean P, Vervaet Chris, Ketolainen Jarkko, Sandler Niklas, Rantanen Jukka, Naelapää Kaisa, De Beer Thomas. 2014. European journal of pharmaceutics and biopharmaceutics. 87: 252-263 -
Near-Infrared Imaging for High-Throughput Screening of Moisture-Induced Changes in Freeze-Dried Formulations
Trnka Hjalte, Palou Anna, Panouillot Pierre-Emanuel, Kauppinen Ari, Toiviainen Maunu, Grohganz Holger, Alcalà Manel, Juuti Mikko, Ketolainen Jarkko, Rantanen Jukka. 2014. Journal of pharmaceutical sciences. 103: 2839-2846 -
Non-contact weight measurement of flat-faced pharmaceutical tablets using terahertz transmission pulse delay measurements
Bawuah Prince, Silfsten Pertti, Ervasti Tuomas, Ketolainen Jarkko, Zeitler J. Axel, Peiponen Kai-Erik. 2014. International journal of pharmaceutics. 276: 16-22 -
Pharmaceutical solids and processes
Ketolainen Jarkko, Korhonen Ossi, Laitinen Riikka, Simonaho Simo-Pekka, Molnár Ferdinand. 2014. Dosis. 30: 195 -
Phase separation in co-amorphous systems: in silico prediction and the experimental challenge of detection
Pajula Katja, Wittoek Lieke, Lehto Vesa-Pekka, Ketolainen Jarkko, Korhonen Ossi. 2014. Molecular pharmaceutics. 11: 2271-2279 -
Structural attributes of model protein formulations prepared by rapid freeze-drying cycles in a microscale heating stage
Peters Björn-Hendrik, Molnár Ferdinand, Ketolainen Jarkko. 2014. European journal of pharmaceutics and biopharmaceutics. 87: 347-356 -
Towards a Noninvasive Detection of the Porosity, Absolute Weight and Height of Pharmaceutical Compacts Using a Training Set of Tablets and THz Pulse Delay
P. Bawuah, P. Silfsten, T. Ervasti, J. Ketolainen, A. Zeitler, K-E. Peiponen. 2014. -
Validation of a multipoint near-infrared spectroscopy method for in-line moisture content analysis during freeze-drying
Kauppinen Ari, Toiviainen Maunu, Lehtonen Marko, Järvinen Kristiina, Paaso Janne, Juuti Mikko, Ketolainen Jarkko. 2014. Journal of pharmaceutical and biomedical analysis. 95: 229-237 -
Validation of a multipoint near-infrared spectroscopy method for in-line moisture content determination during freeze-drying
Kauppinen Ari, Toiviainen Maunu, Lehtonen Marko, Järvinen Kristiina, Paaso Janne, Juuti Mikko, Ketolainen Jarkko. 2014. -
Broadening of a THz pulse as a measure of the porosity of pharmaceutical tablets
Peiponen K-E, Silfsten P, Pajander J, Ketolainen J. 2013. International journal of pharmaceutics. 447: 7-11 -
Effect of cocrystallization techniques on compressional properties of caffeine/oxalic acid 2:1 cocrystal
Aher Suyog, Dhumal Ravindra, Mahadik Kakasaheb, Ketolainen Jarkko, Paradkar Anant. 2013. Pharmaceutical development and technology. 18: 55-60 -
Farmasian teknologia ja biofarmasia - uusia teknologioita lääkekehitykseen monitieteellisellä yhteistyöllä
Laitinen Riikka, Honkakoski Paavo, Järvinen Kristiina, Ketolainen Jarkko. Teoksessa: Ahonen R, Laitinen K, Lapinjoki S, Mensalo P, Ranta V-P, Ylikangas H (toim).(toim.) , 2013. Muutosten vuosikymmen : Itä-Suomen yliopiston farmasian laitos 40 vuotta. s. 24-30. -
In-line multipoint near-infrared spectroscopy for moisture content quantification during freeze-drying
Kauppinen Ari, Toiviainen Maunu, Korhonen Ossi, Aaltonen Jaakko, Järvinen Kristiina, Paaso Janne, Juuti Mikko, Ketolainen Jarkko. 2013. Analytical chemistry. 85: 2377-2384 -
Micro-scale freeze-drying with Raman spectroscopy as a tool for process development
Kauppinen Ari, Toiviainen Maunu, Aaltonen Jaakko, Korhonen Ossi, Järvinen Kristiina, Juuti Mikko, Pellinen Riikka, Ketolainen Jarkko. 2013. Polymorfi -
Microscale freeze-drying with Raman spectroscopy as a tool for process development
Kauppinen Ari, Toiviainen Maunu, Aaltonen Jaakko, Korhonen Ossi, Järvinen Kristiina, Juuti Mikko, Pellinen Riikka, Ketolainen Jarkko. 2013. Analytical chemistry. 85: 2109-2116 -
Validation of a multipoint near-infrared spectroscopy method for in-line moisture content determination during freeze-drying
Kauppinen Ari, Toiviainen Maunu, Lehtonen Marko, Järvinen Kristiina, Paaso Janne, Juuti Mikko, Ketolainen Jarkko. 2013. EUFEPS -
Visualization and understanding of the granulation liquid mixing and distribution during continuous twin screw granulation using NIR chemical imaging
Vercruysse Jurgen, Toiviainen Maunu, Fonteyne Margot, Helkimo Niko, Ketolainen Jarkko, Juuti Mikko, Delaet Urbain, Van Assche Ivo, Remon Jean P, Vervaet Chris, De Beer Thomas. 2013. European journal of pharmaceutics and biopharmaceutics. 2014:86: 383-392 -
A study on the resolution of a terahertz spectrometer for the assessment of the porosity of pharmaceutical tablets
Ervasti Tuomas, Silfsten Pertti, Ketolainen Jarkko, Peiponen Kai-Erik. 2012. Applied spectroscopy. 66: 319-323 -
Characterization of porous media by means of the depolarization metrics
Savenkov S, Piezzhev A, Oberemok Ye, Silfsten P, Ervasti T, Ketolainen J, Peiponen K-E. 2012. Journal of quantitative spectroscopy and radiative transfer. 113: 2503-2511 -
Computational approach for fast screening of small molecular candidates to inhibit crystallization in amorphous drugs
Pajula Katja, Lehto Vesa-Pekka, Ketolainen Jarkko, Korhonen Ossi. 2012. Molecular pharmaceutics. 9: 2844-2855 -
Eyecon particle imager in granule size measurements: A case study with Cellets
Ervasti Tuomas, Rudolph Stefan, Ketolainen Jarkko. 2012. -
Freeze drying formulation and process design using Raman spectrometer equipped micro scale freeze drying stage
Kauppinen Ari, Toiviainen Maunu, Korhonen Ossi, Aaltonen Jaakko, Järvinen Kristiina, Juuti Mikko, Ketolainen Jarkko. 2012. -
In-line moisture content monitoring of the freeze dried products using multipoint NIR spectroscopy
Kauppinen Ari, Toiviainen Maunu, Korhonen Ossi, Aaltonen Jaakko, Järvinen Kristiina, Juuti Mikko, Ketolainen Jarkko. 2012. -
PROMIS Centre - innovative pharmaceutical manufacturing research and technology development in Kuopio, Finland
Simonaho Simo-Pekka, Laitinen Riikka, Rimpiläinen Ville, Heikkinen Lasse, Vauhkonen Marko, Paaso Janne, Juuti Mikko, Ketolainen Jarkko. 2012. Dosis. 28: 251-260 -
Predicting granule size distribution of a fluidized bed spray granulation process by regime based PLS modeling of acoustic emission data
Poutiainen Sami, Matero Sanni, Hämäläinen Tatu, Leskinen Jari, Ketolainen Jarkko, Järvinen Kristiina. 2012. Powder technology. 228: 149-157 -
Real-time tablet formation monitoring with ultrasound measurements in eccentric single station tablet press
Leskinen Jari T, Simonaho Simo-Pekka, Hakulinen Mikko, Ketolainen Jarkko. 2012. International journal of pharmaceutics. 2013:442: 27-34 -
Strategic funding priorities in the pharmaceutical sciences allied to Quality by Design (QbD) and Process Analytical Technology (PAT)
Aksu Buket, De Beer Tomas, Folestad Staffan, Ketolainen Jarkko, Lindén Hans, Lopes Joao A, de Matas Marcel, Oostra Wim, Rantanen Jukka, Weimer Marco. 2012. European journal of pharmaceutical sciences. 47: 402-405 -
X-ray microtomography analysis of intragranular drug migration during fluidized bed and oven tray drying
Poutiainen Sami, Honkanen Marko, Becker Johanna, Nachtweide Dominique, Järvinen Kristiina, Ketolainen Jarkko. 2012. Journal of pharmaceutical sciences. 101: 1587-1598 -
A density based segmentation method to determine the coordination number of a particulate system
Nguyen Thanh T, Tran Thanh N, Willemsz Tofan A, Frijlink Henderik W, Ervasti Tuomas, Ketolainen Jarkko, van der Voort Maarschalk Kees. 2011. Chemical engineering science. 66: 6385-6392 -
An LED-based multispectral imaging system for tablet quality control
Ervasti Tuomas, Nippolainen Ervin, Toiviainen Maunu, Kuivalainen Kalle, Ketolainen Jarkko, Aaltonen Jaakko. 2011. -
Determination of water content in freeze dried samples using NIR spectroscopy
Kauppinen Ari, Toiviainen Maunu, Aaltonen Jaakko, Korhonen Ossi, Järvinen Kristiina, Ketolainen Jarkko. 2011. Polymorfi -
Electrical capacitance tomography as a monitoring tool for high-shear mixing and granulation
Rimpiläinen Ville, Poutiainen Sami, Heikkinen Lasse M, Savolainen Tuomo, Vauhkonen Marko, Ketolainen Jarkko. 2011. Chemical engineering science. 66: 4090-4100 -
Evolution of granule structure and drug content during fluidized bed granulation by X-ray microtomography and confocal Raman spectroscopy
Poutiainen Sami, Pajander Jari, Savolainen Armi, Ketolainen Jarkko, Järvinen Kristiina. 2011. Journal of pharmaceutical sciences. 100: 5254-5269 -
Fast-dissolving sublingual solid dispersion and cyclodextrin complex increase the absorption of perphenazine in rabbits
Turunen Elina, Mannila Janne, Laitinen Riikka, Riikonen Joakim, Lehto Vesa-Pekka, Järvinen Tomi, Ketolainen Jarkko, Järvinen Kristiina, Jarho Pekka. 2011. Journal of pharmacy and pharmacology. 63: 19 - 25 -
Kramers-Kronig analysis on the real refractive index of porous media in the terahertz spectral range
Silfsten Pertti, Kontturi Ville, Ervasti Tuomas, Ketolainen Jarkko, Peiponen Kai-Erik. 2011. Optics letters. 36: 778-780 -
Screening of excipients for stabilizing Semliki Forest virus vector during freeze-drying
Kauppinen Ari, Ruottinen Ville-Petteri, Karttunen Anssi-Pekka, Ruotsalainen Janne, Pellinen Riikka, Järvinen Kristiina, Hinkkanen Ari, Ketolainen Jarkko. 2011. -
Screening of excipients for stabilizing Semliki Forest virus vector during freeze-drying
Kauppinen Ari, Ruottinen Ville-Petteri, Karttunen Anssi-Pekka, Ruotsalainen Janne, Pellinen Riikka, Järvinen Kristiina, Hinkkanen Ari, Ketolainen Jarkko. 2011. -
Surface-active derivative of inulin (Inutec® SP1) is a superior carrier for solid dispersions with a high drug load
Srinarong Parinda, Hämäläinen Suvi, Visser Marinella R, Hinrichs Wouter L J, Ketolainen Jarkko, Frijlink Henderik W. 2011. Journal of pharmaceutical sciences. 100: 2333 - 2342 -
Taking PAT to the next level
Ciurczak Emil, Ketolainen Jarkko, Laitinen Riikka, Aaltonen Jaakko, Lindén Hans. 2011. European journal of pharmaceutical sciences. 42: 1-2 -
Ultrasound transmission measurements for tensile strength evaluation of tablets
Simonaho Simo-Pekka, Takala Aleksi T, Kuosmanen Marko, Ketolainen Jarkko. 2011. International journal of pharmaceutics. 409: 104-110 -
An optical method for continuous monitoring of the dissolution rate of pharmaceutical powders
Laitinen R, Lahtinen J, Silfsten P, Vartiainen E, Jarho P & Ketolainen J. 2010. Journal of pharmaceutical and biomedical analysis. 52: 181 - 189 -
Design of freeze drying process for an adenovirus vector
Kauppinen Ari, Pellinen Riika, Karjalainen Mikko, Korhonen Ossi, Aaltonen Jaakko, Heikkilä Katri, Järvinen Kristiina, Nokelainen Minna, Ketolainen Jarkko. 2010. -
Designing of freeze drying cycle for an adenovirus vector
Kauppinen Ari, Pellinen Riikka, Karjalainen Mikko, Korhonen Ossi, Aaltonen Jaakko, Heikkilä Katri, Järvinen Kristiina, Nokelainen Minna, Ketolainen Jarkko. 2010. -
ELECTRICAL IMPEDANCE TOMOGRAPHY FOR THREE-DIMENSIONAL DRUG RELEASE MONITORING
Rimpiläinen V, Kuosmanen M, Ketolainen J, Järvinen K, Vauhkonen M & Heikkinen LM. 2010. European journal of pharmaceutical sciences. 41: 407-413 -
Effect of freeze-drying conditions on transfection efficiency of cationic polymer DNA complexes
Kauppinen Ari, Reinisalo Mika, Pellinen Riikka, Korhonen Ossi, Järvinen Kristiina, Ketolainen Jarkko. 2010. Polymorfi -
Estimation of granule size distribution for batch fluidized bed granulation process using acoustic emission and N-way PLS
Matero S, Poutiainen S, Leskinen J, Järvinen K, Ketolainen J, Poso A & Reinikainen S-P. 2010. Journal of chemometrics. 24: 464-471 -
Fast noncontact measurements of tablet dye concentration
Ervin Nippolainen, Tuomas Ervasti, Laure Fauch, Serguei V. Miridonov, Jarkko Ketolainen, Alexei A. Kamshilin. 2010. Optics express. 18: 15634 -
In-line ultrasound measurement system for detecting tablet integrity
Jari Leskinen, Simo-Pekka Simonaho, Mikko Antero Hakulinen, Jarkko Ketolainen. 2010. International journal of pharmaceutics. 400: 104-113 -
Labscale fluidized bed granulator instrumented with non-invasive process monitoring devices
Leskinen J, Okkonen M, Toiviainen M, Poutiainen S, Tenhunen M, Teppola P, Lappalainen R, Ketolainen J, Järvinen K.. 2010. Chemical engineering journal. 164: 268-274 -
MONITORING OF HIGH-SHEAR MIXING AND GRANULATION WITH CAPACITIVE MEASUREMENTS AND TOMOGRAPHY
Rimpiläinen V, Poutiainen S, Heikkinen LM, Savolainen T, Vauhkonen M & Ketolainen J. Teoksessa: Liu S, Takei M & Wang M(toim.) , 2010. 6th World Congress on Industrial Process Tomography. s. 44-51. -
Measuring tablet porosity using multispectral imaging system
E. Nippolainen, T. Ervasti, J. Ketolainen, A. A. Kamshilin. 2010. Optical review. 17: 323-326 -
Monitoring of swelling of hydrophilic polymer matrix tablets by ultrasound techniques
Leskinen Jari, Hakulinen Mikko Antero, Kuosmanen Marko, Ketolainen Jarkko, Abrahmsén-Alami Susanna, Lappalainen Reijo. 2010. International journal of pharmaceutics. 404: 142-147 -
Perphenazine solid dispersions for orally fast-disintegrating tablets: physical stability and formulation
Laitinen R, Suihko E, Bjorkqvist M, Riikonen J, Lehto V-P, Jarvinen K & Ketolainen J. 2010. Drug development and industrial pharmacy. 36: 601 - 613 -
Predicting the formation and stability of amorphous small molecule binary mixtures from computationally determined Flory-Huggins interaction parameter and phase diagram
Pajula K, Taskinen M, Lehto V-P, Ketolainen J & Korhonen O. 2010. Molecular pharmaceutics. 7: 795-804 -
Spontaneous formation of theophylline-nicotinamide cocrystals
Ervasti Tuomas, Ketolainen Jarkko, Aaltonen Jaakko. 2010. -
Wiener bounds for complex permittivity in terahertz spectroscopy: case study of two-phase pharmaceutical tablets
Tuononen H, Fukunaga K, Kuosmanen M, Ketolainen J & Peiponen K-E. 2010. Applied spectroscopy. 64: 127-131 -
An electrical impedance tomography-based approach to monitor in vitro sodium chloride dissolution from pharmaceutical tablets
Rimpiläinen V, Heikkinen LM, Kuosmanen M, Lehikoinen A, Voutilainen A, Vauhkonen M, Ketolainen J. 2009. Review of scientific instruments. 80: -
Determining the critical properties of formulations for freeze drying by DSC and FDM
Kauppinen Ari, Reinisalo Mika, Pellinen Riikka, Gieseler Henning, Schneid Stefan, Rutzinger Susanne, Beirowski Jakob, Korhonen Ossi, Järvinen Kristiina, Ketolainen Jarkko. 2009. -
Effect of formulation parameters and drug-polymer interactions on drug release from starch acetate matrix tablets
Pajander J, Korhonen O, Laamanen M, Ryynänen E-L, Grimsey I, Van Veen B, Ketolainen J. 2009. Journal of pharmaceutical sciences. 98: 3676-3690 -
Intraorally fast-dissolving particles of a poorly soluble drug: Preparation and in vitro characterization
Laitinen R, Suihko E, Toukola K, Björkqvist M, Riikonen J, Lehto V-P, Järvinen K, Ketolainen J. 2009. European journal of pharmaceutics and biopharmaceutics. 71: 271-281 -
Monitoring the wetting phase of fluidized bed granulation process using multi-way methods: The separation of successful from unsuccessful batches
Matero S, Poutiainen S, Leskinen J, Reinikainen S-P, Ketolainen J, Järvinen K, Poso A. 2009. Chemometrics and intelligent laboratory systems. 96: 88-93 -
Optical and terahertz measurement techniques for flat-faced pharmaceutical tablets: a case study of gloss, surface roughness and bulk properties of starch acetate tablets
Juuti M, Tuononen H, Prykari T, Kontturi V, Kuosmanen M, Alarousu E, Ketolainen J, Myllyla R, Peiponen KE. 2009. Measurement science and technology. 20: Article Number: 015301 -
Optical and terahertz measurement techniques for flat-faced pharmaceutical tablets: a case study of gloss, surface roughness and bulk properties of starch acetate tablets
Juuti M, Tuononen H, Prykäri T, Kontturi V, Kuosmanen M, Alarousu E, Ketolainen J, Myllylä R, Peiponen K-E. 2009. Measurement science and technology. 20: [9 pp] -
The feasibility of using acoustic emissions for monitoring of fluidized bed granulation
Matero S, Poutiainen S, Leskinen J, Järvinen K, Ketolainen J, Reinikainen S-P, Hakulinen M, Lappalainen R, Poso A. 2009. Chemometrics and intelligent laboratory systems. 97: 75-81 -
Uncertainty in dissolution test of drug release
Paakkunainen M, Matero S, Ketolainen J, Lahtela-Kakkonen M, Poso A, Reinikainen S-P. 2009. Chemometrics and intelligent laboratory systems. 97: 82-90 -
Determination of batch-to-batch variation for fluidized bed granulation
Matero S, Poutiainen S, Leskinen J, Hakulinen M, Lahtela-Kakkonen M, Ketolainen J, Lappalainen R, Järvinen K & Poso A. 2008. European journal of pharmaceutical sciences -
Dissolution monitoring of hydrophilic matrix tablets by using frequency information of ultrasound echo
Leskinen J, Hakulinen A, Ketolainen J, Abrahamsen-Alami S, Kuosmanen M and Lappalainen R.. 2008. European journal of pharmaceutical sciences -
Drug release phenomena within a hydrophobic starch acetate matrix: FTIR mapping of tablets after in vitro dissolution testing
Pajander J, Soikkeli A, Korhonen O, Forbes RT, Ketolainen J. 2008. Journal of pharmaceutical sciences. 97: 3367-3378 -
Estimation of drug release profiles of a heterogeneous set of drugs from a hydrophobic matrix tablet using molecular descriptors
Matero S, Reinikainen S-P, Lahtela-Kakkonen M, Korhonen O, Ketolainen J, Poso A. 2008. Journal of chemometrics. 22: 653-660 -
Ultrasound transmission technique as a potential tool for physical evaluation of monolithic matrix tablets
Hakulinen MA, Pajander J, Leskinen J, Ketolainen J, van Veen B, Niinimäki K, Pirskanen K, Poso A, Lappalainen R. 2008. AAPS PharmSciTech. 9: 267-273 -
Modifying drug release and tablet properties of starch acetate tablets by dry powder agglomeration
Mäki R, Suihko E, Rost S, Heiskanen M, Murtomaa M, Lehto V-P, Ketolainen J. 2007. Journal of pharmaceutical sciences. 96: 438-447 -
Predicting the drug concentration in starch acetate matrix tablets from ATR-FTIR spectra using multi-way methods
Matero S, Pajander J, Soikkeli A-M, Reinikainen S-P, Lahtela-Kakkonen M, Korhonen O, Ketolainen J, Poso A. 2007. Analytica chimica acta. 595: 190-197 -
Teollisen lääkkeenvalmistuksen opetusta lähes aidossa ympäristössä. Kuopion yliopiston teollisen lääkkeenvalmistuksen kurssi rantautui Sotilasapteekin Viitasaaren toimintayksikköön
Nurmi T, Kangasmäki J, Ketolainen J. 2007. Dosis. 23: 53-56 -
Chemical space of orally active compounds
Matero S, Lahtela-Kakkonen M, Korhonen O, Ketolainen J, Lappalainen R, Poso A. 2006. Chemometrics and intelligent laboratory systems. 84: 134-141 -
Controlled release of saccharides from matrix tablets
Mäki R, Suihko E, Korhonen O, Pitkänen H, Niemi R, Lehtonen M, Ketolainen J. 2006. European journal of pharmaceutics and biopharmaceutics. 62: 163-170 -
Liquid boundary movements in cylindrical and convex hydrophobic matrix tablets: effects on tablet cracking and drug release
Pajander J, van Veen B, Korhonen O, Lappalainen R, Ketolainen J. 2006. European journal of pharmaceutics and biopharmaceutics. 64: 167-172 -
Local and average gloss from flat-faced sodium chloride tablets
M. Juuti;B. van Veen;K.-E. Peiponen;J. Ketolainen;V. Kalima;R. Silvennoinen and T.T. Pakkanen. 2006. AAPS PharmSciTech. 7: Article 7 -
Local and average gloss from flat-faced sodium chloride tablets
Juuti M, van Veen B, Peiponen K-E, Ketolainen J, Kalima V, Silvennoinen R, Pakkanen TT. 2006. AAPS PharmSciTech. 7: Article 7 -
Partial least square projections to latent structures analysis (PLS) in evaluating and predicting drug release from starch acetate matrix tablets
Korhonen O, Matero S, Poso A, Ketolainen J. 2005. Journal of pharmaceutical sciences. 94: 2716-2730 -
Prediction of contact angle for pharmaceutical solids from their molecular structure
Suihko E, Forbes RT, Korhonen O, Ketolainen J, Paronen P, Gynther J, Poso A. 2005. Journal of pharmaceutical sciences. 94: 745-758 -
The effect of powder blend and tablet structure on drug release mechanisms of hydrophobic starch acetate matrix tablets
van Veen B , Pajander J, Zuurman K, Lappalainen R, Poso A, Frijlink HW, Ketolainen J. 2005. European journal of pharmaceutics and biopharmaceutics. 61: 149-157 -
Aqueous starch acetate dispersion as a novel coating material for controlled release products
Tarvainen M, Peltonen S, Mikkonen H, Elovaara M, Tuunainen M, Paronen P, Ketolainen J, Sutinen R. 2004. Journal of controlled release. 96: 179-191 -
Evaluation of novel starch acetate-diltiazem controlled release tablets in healthy human volunteers
Korhonen O, Kanerva H, Vidgren M, Urtti A, Ketolainen J. 2004. Journal of controlled release. 95: 515-520 -
Starch acetate as a tablet matrix for sustained drug release
Pohja S, Suihko E, Vidgren M, Paronen P, Ketolainen J. 2004. Journal of controlled release. 94: 293-302 -
Effects of physical properties for starch acetate powders on tableting [online]
Korhonen O, Pohja S, Peltonen S, Suihko E, Vidgren M, Paronen P, Ketolainen J. 2002. AAPS PharmSciTech. 3: [21.2.2003] -
Complexation with tolbutamide modifies the physicochemical and tableting properties of hydroxypropyl-beta-cyclodextrin
Suihko E, Korhonen O, Järvinen T, Ketolainen J, Jarho P, Laine E, Paronen P. 2001. International journal of pharmaceutics. 215: 137-145 -
Dynamic solid-state and tableting properties of four theophylline forms
Suihko E, Lehto V-P, Ketolainen J, Laine E, Paronen P. 2001. International journal of pharmaceutics. 217: 225-236 -
Deformation behaviors of tolbutamide, hydroxypropyl-beta-cyclodextrin, and their dispersions
Suihko E, Poso A, Korhonen O, Gynther J, Ketolainen J, Paronen P. 2000. Pharmaceutical research. 17: 942-948 -
Computational elasticity of anhydrous betalactose
Päivärinta J, Poso A, Gynther J, Suihko E, Ketolainen J. Teoksessa: (toim.) , 1997. 16th Pharmaceutical Technology Conference and Exhibition. Vol. 2.. s. 509-522. -
Evaluation of physical properties of tolbutamide/hydroxypropyl-ß-cyclodextrin inclusion complex
Suihko E, Korhonen O, Järvinen T, Ketolainen J, Laine E, Paronen P. Teoksessa: (toim.) , 1997. 16th Pharmaceutical Technology Conference and Exhibition. Vol. 2.. s. 286-294. -
Optical homogeneity of tablet surfaces
Ketolainen J, Silvennoinen R, Peiponen K-E, Laakkonen P, Suihko E, Räsänen J, Matsuda K, Paronen P. Teoksessa: (toim.) , 1997. 16th Pharmaceutical Technology Conference and Exhibition. Vol. 1a.. s. 624-628. -
Predicting preferred orientation of crystals due to tabletting from particle image analysis
Avila E, Suihko E, Muñoz-Ruiz A, Jimenez-Castellanos M, Justo A, Cucala J, Ketolainen J, Paronen P. Teoksessa: (toim.) , 1997. 16th Pharmaceutical Technology Conference and Exhibition. Vol. 1a.. s. 617-623. -
A comparison of three- and four-point beam bending tests using double-exposure holographic interferometry
Raatikainen P, Silvennoinen R, Ketolainen J, Ketolainen P, Paronen P. Teoksessa: (toim.) , 1996. Proceedings of the 15th Pharmaceutical Technology Conference. Vol. 1a.. s. 356-361. -
Evaluation of compressional characteristics of some excipients using ultrasonic measurement
Raatikainen P, Stor-Pellinen J, Räikkönen H, Ketolainen J, Luukkala M, Paronen P. Teoksessa: (toim.) , 1996. Proceedings of the 15th Pharmaceutical Technology Conference. Vol 1a.. s. 351-355. -
Holographic evaluation of bending and integrity of pharmaceutical powder beams
Silvennoinen R, Raatikainen P, Ketolainen J, Ketolainen P, Paronen P. 1996. International journal of pharmaceutics. 131: 209-217 -
Partial least squares (pls) analysis in prediction of contact angles for pharmaceutical materials
Suihko E, Poso A, Ketolainen J, Gynther J, Paronen P. Teoksessa: (toim.) , 1996. Proceedings of the 15th Pharmaceutical Technology Conference. Vol. 2a.. s. 259-264. -
Changes in solid-state structure of cyclophosphamide monohydrate induced by mechanical treatment and storage
Ketolainen J, Poso A, Viitasaari V, Gynther J, Pirttimäki J, Laine E, Paronen P. 1995. Pharmaceutical research. 12: 299-304 -
Characterization of physical properties of theophylline and its polymorphs
Ketolainen J, Suihko E, Poso A, Ahlgren M, Gynther J, Paronen P. Teoksessa: (toim.) , 1995. Proceedings of the 14th Pharmaceutical Technology Conference. Vol. 3. s. 109-115. -
Evaluation of Changes in Physical Properties of Tablets and Tableting Materials due to Mechanical and Thermal Stress
Ketolainen J. 1995. Kuopion yliopiston julkaisuja A. Farmaseuttiset tieteet -
Evaluation of elasticity and homogeneity of compacts by double-exposure holographic interferometry
Raatikainen P, Silvennoinen R, Ketolainen J, Ketolainen P, Paronen P. Teoksessa: (toim.) , 1995. Proceedings of the 14th Pharmaceutical Technology Conference. Vol. 1. s. 125-133. -
Photoacoustic evaluation of elasticity and integrity of pharmaceutical tablets
Ketolainen J, Oksanen M, Rantala J, Stor-Pellinen J, Luukkala M, Paronen P. 1995. International journal of pharmaceutics. 125: 45-53 -
Photoacoustic investigation of tablet integrity
Ketolainen J, Oksanen M, Rantala J, Stor-Pellinen J, Luukkala M, Paronen P. Teoksessa: (toim.) , 1995. Proceedings of the 14th Pharmaceutical Technology Conference. s. 561-565. -
Thermophysical properties of some pharmaceutical excipients compressed in tablets
Ketolainen J, Kubicár L, Bohác V, Markovic M, Paronen P. 1995. Pharmaceutical research. 12: 1701-1707 -
Critical evaluation of three point bending test for measuring Young's modulus of pharmaceutical powders
Raatikainen P, Pöntinen T, Ilkka J, Ketolainen J, Paronen P. Teoksessa: (toim.) , 1994. Proceedings of the 13th Pharmaceutical Technology Conference. s. 192-203. -
Evaluation of thermophysical properties of pharmaceutical tablets by heat pulse method
Ketolainen J, Kubicar L, Bohac V, Markovic M, Laakkonen M, Paronen P. Teoksessa: (toim.) , 1994. Proceedings of the 13th Pharmaceutical Technology Conference. s. 141-151. -
Pulsed photoacustic evaluation of tablet integrity
Oksanen M, Ketolainen J, Rantala J, Stor-Pellinen J, Paronen P, Luukkala M. Teoksessa: Thompson DO, Chimenti DE(toim.) , 1994. Review of Progress in Quantitative Nondestructive Evaluation. s. 449-453. Plenum Press