JENNI KUBLBECK

Senior Researcher

PhD

Contact info

Organization

Faculty of Health Sciences, A.I. Virtanen Institute for Molecular Sciences

Email

jenni.kublbeck@uef.fi

Phone

-

Keywords

ADME research bromodomains cell culture drug metabolism edcmet endocrine disruptors gene regulation hepatic cells in vitro models metabolic diseases nuclear receptors pharmacy sirtuins toxicology

Releases in SoleCRIS

CRIS Jenni Küblbeck

Research groups - UEF

Links

Publications

Sakhteman, A; Failli, M; Kublbeck, J; Levonen, AL; Fortino, V. 2021. A toxicogenomic data space for system-level understanding and prediction of EDC-induced toxicity Environment international 156: 106751. 2021
Tenhunen, Jonna; Kucera, Tomáš; Huovinen, Marjo; Küblbeck, Jenni; Bisenieks, Egils; Vigante, Brigita; Ogle, Zaiga; Duburs, Gunars; Doležal, Martin; Moaddel, Ruin; Lahtela-Kakkonen, Maija; Rahnasto-Rilla, Minna. 2021. Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells Biomedicine and pharmacotherapy 138: 111452. 2021
Küblbeck, Jenni; Niskanen, Jonna; Honkakoski, Paavo. 2020. Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR Cells 9 10: 2306. 2020
Küblbeck, Jenni; Vuorio, Taina; Niskanen, Jonna; Fortino, Vittorio; Braeunin, Albert; Abass, Khaled; Rautio, Arja; Hakkola, Jukka; Honkakoski, Paavo; Levonen, Anna-Liisa. 2020. The EDCMET project: Metabolic effects of endocrine disruptors International journal of molecular sciences 21 8: 3021. 2020
Rahnasto-Rilla, Minna; Järvenpää, Joni; Huovinen, Marjo; Schroderus, Anna-Mari; Ihantola, Emmi-Leena; Küblbeck, Jenni; Khadeer, Mohammed; Moaddel, Ruin; Lahtela-Kakkonen, Maija. 2020. Effects of galloflavin and ellagic acid on sirtuin 6 and its anti-tumorigenic activities Biomedicine and pharmacotherapy 131: 110701. 2020
A Reverse Transfection Method for Screening of Nuclear Receptor Activators. Küblbeck, Jenni; Honkakoski, Paavo / Nuclear Receptors. 2019. 2019
Giantin, M; Küblbeck, J; Zancanella, V; Prantner, V; Sansonetti, F; Schoeniger, A; Tolosi, R; Guerra, G; Da Ros, S; Dacasto, M; Honkakoski, P. 2019. DNA elements for constitutive androstane receptor- and pregnane X receptor-mediated regulation of bovine CYP3A28 gene PLoS ONE 14 3: e0214338. 2019
Juvonen, RO; Novák, F; Emmanouilidou, E; Auriola, S; Timonen, J; Heikkinen, AT; Küblbeck, J; Finel, M; Raunio, H. 2019. Metabolism of Scoparone in Experimental Animals and Humans Planta medica 85 06: 453-464. 2019
Küblbeck, Jenni; Huovinen, Marjo. 2019. Isoflavonien turvallisuus ja tutkimuksen haasteet Dosis 35 3: 274-289. 2019
Touloupi, K; Kublbeck, J; Magklara, A; Molnar, F; Reinisalo, M; Konstandi, M; Honkakoski, P; Pappas, P. 2019. The basis for strain-dependent rat aldehyde dehydrogenase 1A7 (ALDH1A7) gene expression Molecular pharmacology 96 5: 655-663. 2019
Prantner, Viktoria; Cinnamon, Yuval; Küblbeck, Jenni; Molnár, Ferdin; Honkakoski, Paavo. 2018. Functional Characterization of a Novel Variant of the Constitutive Androstane Receptor (CAR, NR1I3) Nuclear Receptor Research 5: 101386. 2018
Küblbeck Jenni, Hakkarainen Jenni J, Petsalo Aleksanteri, Vellonen Kati-Sisko, Tolonen Ari, Reponen Petri, Forsberg Markus M, Honkakoski Paavo. 2016. Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity. JOURNAL OF PHARMACEUTICAL SCIENCES 105 2: 941-949. 2016
Toivonen Sanna, Malinen Melina M, Küblbeck Jenni, Petsalo Aleksanteri, Urtti Arto, Honkakoski Paavo, Otonkoski Timo. 2016. Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models. TISSUE ENGINEERING 22 13-14: 971-984. 2016
Küblbeck Jenni, Zancanella Vanessa, Prantner Victoria, Molnár Ferdinand, Squires E. James, Dacasto Mauro, Honkakoski Paavo, Giantin Mery. 2015. Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons. XENOBIOTICA (LONDON) 46 (2016) 3: 200-210. 2015
Küblbeck Jenni, Anttila Teemu, Pulkkinen Juha T, Honkakoski Paavo. 2015. Improved assays for xenosensor activation based on reverse transfection. TOXICOLOGY IN VITRO 29 7: 1759-1765. 2015
Giantin M., Zancanella V., Kueblbeck J., Prantner V., Sansonetti F., Honkakoski P., Dacasto M.. 2015. Regulation of bovine CYP3A28 promoter by pregnane X receptor (PXR) and constitutive androstane receptor (CAR). 56-57. 2015
Honkakoski Paavo, Molnár Ferdinand, Kublbeck Jenni. 2014. Lääkeaineiden metaboliaa ja kuljetusta säätelevät tumareseptorit. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 30 3: 193. 2014
Mattinen Laura, Kublbeck Jenni, Rechardt Oona, Honkakoski Paavo, Rautio Jari. 2014. Direct and Rapid Transcript Analysis Assay for CYP mRNA Expression and Inducibility in Human Primary Hepatocytes. Drug Metabolism Letters 8 2: 77-87. 2014
Poutiainen Pekka K, Huhtala Tuulia, Jääskeläinen Tiina, Petsalo Aleksanteri, Küblbeck Jenni, Kaikkonen Sanna, Palvimo Jorma J, Raunio Hannu, Närvänen Ale, Peräkylä Mikael, Juvonen Risto O, Honkakoski Paavo, Laatikainen Reino, Pulkkinen Juha T. 2014. Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator. MOLECULAR AND CELLULAR ENDOCRINOLOGY 387: 8-18. 2014
Molnár Ferdinand, Küblbeck Jenni, Jyrkkärinne Johanna, Prantner Viktória, Honkakoski Paavo. 2013. An update on the constitutive androstane receptor (CAR). Drug Metabolism and Drug Interactions 28 2: 79-93. 2013
Pimkaew Prapapan, Küblbeck Jenni, Petsalo Aleksanteri, Jukka Jouni, Suksamrarn Apichart, Juvonen Risto, Auriola Seppo, Piyachaturawat Pawinee, Honkakoski Paavo. 2013. Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system. TOXICOLOGY IN VITRO 27 6: 2005-2012. 2013
Ma Liang, Barker Jeremy, Zhou Changchun, Li Wei, Zhang Jing, Lin Biaoyang, Foltz Gregory, Küblbeck Jenni, Honkakoski Paavo. 2012. Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system BIOMATERIALS 33: 4353-4361. 2012
Jyrkkärinne Johanna, Küblbeck Jenni, Pulkkinen Juha, Honkakoski Paavo, Laatikainen Reino, Poso Antti, Laitinen Tuomo. 2012. Molecular dynamics simulations for human CAR inverse agonists. JOURNAL OF CHEMICAL INFORMATION AND MODELING 52: 457-464. 2012
Küblbeck Jenni. 2012. Use of Xenosensors for Drug Metabolism Studies. Focus on Constitutive Androstane Receptor. Publications of the University of Eastern Finland. Dissertations in Health Sciences 130. 2012
Abass Khaled, Lämsä Virpi, Reponen Petri, Küblbeck Jenni, Honkakoski Paavo, Mattila Sampo, Pelkonen Olavi, Hakkola Jukka. 2012. Characterization of human cytochrome P450 induction by pesticides TOXICOLOGY 294: 17-26. 2012
Küblbeck Jenni, Jyrkkärinne Johanna, Molnár Ferdinand, Kuningas Tiina, Patel Jayendra, Windshügel Björn, Nevalainen Tapio, Laitinen Tuomo, Sippl Wolfgang, Poso Antti, Honkakoski Paavo. 2011. New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists Molecular Pharmaceutics 8: 2424-2433. 2011
Küblbeck Jenni, Laitinen Tuomo, Jyrkkärinne Johanna, Rousu Timo, Tolonen Ari, Abel Tobias, Kortelainen Tanja, Uusitalo Jouko, Korjamo Timo, Honkakoski Paavo, Molnár Ferdinand. 2011. Use of comprehensive screening methods to detect selective human CAR activators BIOCHEMICAL PHARMACOLOGY 82: 1994-2007. 2011
Küblbeck J, Reinisalo M, Mustonen R & Honkakoski P. 2010. Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 40: 263-272. 2010
Jyrkkärinne J, Windshügel B, Rönkkö T, Tervo AJ, Küblbeck J, Lahtela-Kakkonen M, Sippl W, Poso A, Honkakoski P. 2008. Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship. JOURNAL OF MEDICINAL CHEMISTRY 51: 7181-7192. 2008
Küblbeck J, Jyrkkärinne J, Poso A, Turpeinen M, Sippl W, Honkakoski P, Windshügel B. 2008. Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor. BIOCHEMICAL PHARMACOLOGY 76: 1288-1297. 2008
Windshügel B, Jyrkkärinne J, Vanamo J, Poso A, Honkakoski P, Sippl W. 2007. Comparison of homology models and X-ray structures of the nuclear receptor CAR: Assessing the structural basis of constitutive activity JOURNAL OF MOLECULAR GRAPHICS AND MODELLING 25: 644-657. 2007