Jenni Küblbeck

Metabolite-driven remodeling of hepatic lipid metabolism by the plasticizer di-isononyl phthalate

Pitkänen, Sini; Hakomäki, Henriikka; Kärkkäinen, Olli; Lehtonen, Marko; Das, Sreejita; Rysä, Jaana; Küblbeck, Jenni; Levonen, Anna-Liisa, 2026, Molecular metabolism, 110, 102412. A1 Journal article (refereed), original research

Activation of steroid hormone receptors by metabolism-disrupting chemicals

Pitkänen, Sini; Niskanen, Jonna; Mysore, Raghavendra; Niskanen, Einari A; Palvimo, Jorma J; Pijnenburg, Dirk; van Beuningen, Rinie; Rashidian, Azam; Kronenberger, Thales; Poso, Antti; Levonen, Anna-Liisa; Küblbeck, Jenni; Honkakoski, Paavo, 2025, Toxicology and applied pharmacology, 499, 117335. A1 Journal article (refereed), original research

Association between phthalate exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) – systematic literature review

Gogola, Tomasz; Pitkänen, Sini; Huovinen, Marjo; Laitinen, Heikki; Küblbeck, Jenni, 2025, Environmental research, 273, 121186. A2 Review article, Literature review, Systematic review

Drug-Free Approach to Regulate Undruggable Proto-Oncogene MYC Using Biomimetic Porous Nanoparticles for Cancer Immunotherapy

Happonen, Emilia; Dang, Yijing; Wang, Jiajia; Saarela, Silja; Sivonen, Minna; Zakir, Mohammed; Laari, Milla-Iida; Constantinou, Yiannis; Tamarov, Konstantin; Hakkarainen, Henri; Montaser, Ahmed Bisher; Leinonen, Henri; Küblbeck, Jenni; Örd, Tiit; Taipale, Mari; Kaikkonen, Minna; Liu, Ruixian; Klefström, Juha; Yu, Haijun; Xu, Zhiai; Lehto, Vesa-Pekka; Xu, Wujun, 2025, Acs applied materials and interfaces, 17, 33, 46521-46534. A1 Journal article (refereed), original research

Look What You Made Me Do: Discerning Feature for Classification of Endocrine-Disrupting Chemical Binding to Steroid Hormone Receptors

Rashidian, Azam; Pitkänen, Sini; Maltarollo, Vinicius Goncalves; Schoppmeier, Ulrich; Shevchenko, Ekaterina; Medarametla, Prasanthi; Poso, Antti; Küblbeck, Jenni; Honkakoski, Paavo; Kronenberger, Thales, 2025, Journal of chemical information and modeling, 65, 8, 4148-4162. A1 Journal article (refereed), original research

Metabolic disruption by mycotoxins: focus on metabolic endpoints steatosis, adipogenesis and glucose metabolism in vivo and in vitro

Heikkinen, Tia; Küblbeck, Jenni; Rysä, Jaana, 2025, Archives of toxicology, 99, 5, 1749-1767. A2 Review article, Literature review, Systematic review

Nuclear Receptors CAR and PXR as Cardiometabolic Regulators

Hukkanen, Janne; Küblbeck, Jenni; Hakkola, Jukka; Rysä, Jaana, 2025, Pharmacological research, 219, 107892. A2 Review article, Literature review, Systematic review

Uncovering α-Selectivity for Liver X Receptor Agonists for Lipotoxic Cancer Therapies

Galvez B. Pedreira, Júlia; Woelffing, Pascal; Schwarz, Moritz; Ebner, Simon; Rudalska, Ramona; Masberg, Benedikt; Esposito, Aylin; Rashidian, Azam; Schevchenko, Ekaterina; Smutna, Lucie; Pavek, Petr; Kublbeck, Jenni; Kronenberger, Thales; Zender, Lars; Lämmerhofer, Michael; Dauch, Daniel; Laufer, Stefan A, 2025, Journal of medicinal chemistry, 68, 7, 7180-7196. A1 Journal article (refereed), original research

Unmasking metabolic disruptors: The NEMESIS project's quest for Novel Biomarkers, Evidence on Adverse Effects, and Efficient Methodologies

Hakomäki, Henriikka; Pitkänen, Sini; Levonen, Anna-Liisa; Honkakoski, Paavo; Greco, Dario; D'Alessandro, Nicoletta; Saarimäki, Laura Aliisa; Viegas, Susana; Godinho, Cristina; Fyhrquist, Nanna; Wincent, Emma; Lauschke, Volker M; Hukkanen, Janne; Hakkola, Jukka; Vallier, Ludovic; Fortino, Vittorio; Afantitis, Antreas; Sawatani, Toshiaki; Guzman, Tereso J; Cnop, Miriam; Nawrot, Tim; Harlid, Sophia; Vinnars, Marie-Therese; Tardon, Adonina; Grimalt, Joan O; Küblbeck, Jenni; Rysä, Jaana, 2025, Open research Europe, 4, 194. B1 Non-refereed journal articles

Cancer Cells Show Higher Sensitivity to Melatonin-Tamoxifen Drug Conjugates than to Combination of Melatonin and Tamoxifen

Marzouk, Mohamed Akmal; Greco, Sara; Gbahou, Florence; Küblbeck, Jenni; Labani, Nedjma; Jockers, Ralf; Holzgrabe, Ulrike; Wiesmueller, Lisa; Zlotos, Darius P, 2024, ACS omega, 9, 48, 1-15. A1 Journal article (refereed), original research

The KEAP1-NRF2 pathway: Targets for therapy and role in cancer

Adinolfi, Simone; Patinen, Tommi; Jawahar Deen, Ashik; Pitkänen, Sini; Härkönen, Jouni; Kansanen, Emilia; Küblbeck, Jenni; Levonen, Anna-Liisa, 2023, Redox biology, 63, 102726. A2 Review article, Literature review, Systematic review

Gefitinib-Tamoxifen Hybrid Ligands as Potent Agents against Triple-Negative Breast Cancer

Abdelmalek, Carine M.; Hu, Zexi; Kronenberger, Thales; Küblbeck, Jenni; Kinnen, Franziska J.M.; Hesse, Salma S.; Malik, Afsin; Kudolo, Mark; Niess, Raimund; Gehringer, Matthias; Zender, Lars; Witt-Enderby, Paula A.; Zlotos, Darius P.; Laufer, Stefan A., 2022, Journal of medicinal chemistry, 65, 6, 4616-4632. A1 Journal article (refereed), original research

Hormonihäirikköjä lautasella?

Küblbeck, Jenni; Pitkänen, Sini, 2022, Kehittyvä elintarvike, 33, 1, 16-17. D1 Article in a trade journal

Profiling the regulatory interplay of BET bromodomains and Sirtuins in cancer cell lines

Järvenpää, Joni; Rahnasto-Rilla, Minna; Lahtela-Kakkonen, Maija; Küblbeck, Jenni, 2022, Biomedicine and pharmacotherapy, 147, 112652. A1 Journal article (refereed), original research

A toxicogenomic data space for system-level understanding and prediction of EDC-induced toxicity

Sakhteman, A; Failli, M; Kublbeck, J; Levonen, AL; Fortino, V, 2021, Environment international, 156, 106751. A1 Journal article (refereed), original research

Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells

Tenhunen, Jonna; Kucera, Tomá¨; Huovinen, Marjo; Küblbeck, Jenni; Bisenieks, Egils; Vigante, Brigita; Ogle, Zaiga; Duburs, Gunars; Dole¸al, Martin; Moaddel, Ruin; Lahtela-Kakkonen, Maija; Rahnasto-Rilla, Minna, 2021, Biomedicine and pharmacotherapy, 138, 111452. A1 Journal article (refereed), original research

Effects of galloflavin and ellagic acid on sirtuin 6 and its anti-tumorigenic activities

Rahnasto-Rilla, Minna; Järvenpää, Joni; Huovinen, Marjo; Schroderus, Anna-Mari; Ihantola, Emmi-Leena; Küblbeck, Jenni; Khadeer, Mohammed; Moaddel, Ruin; Lahtela-Kakkonen, Maija, 2020, Biomedicine and pharmacotherapy, 131, 110701. A1 Journal article (refereed), original research

DNA elements for constitutive androstane receptor- and pregnane X receptor-mediated regulation of bovine CYP3A28 gene

Giantin, M; Küblbeck, J; Zancanella, V; Prantner, V; Sansonetti, F; Schoeniger, A; Tolosi, R; Guerra, G; Da Ros, S; Dacasto, M; Honkakoski, P, 2019, PLoS ONE, 14, 3, e0214338. A1 Journal article (refereed), original research

Isoflavonien turvallisuus ja tutkimuksen haasteet

Küblbeck, Jenni; Huovinen, Marjo, 2019, Dosis, 35, 3, 274-289. A2 Review article, Literature review, Systematic review

Metabolism of Scoparone in Experimental Animals and Humans

Juvonen, RO; Novák, F; Emmanouilidou, E; Auriola, S; Timonen, J; Heikkinen, AT; Küblbeck, J; Finel, M; Raunio, H, 2019, Planta medica, 85, 6, 453-464. A1 Journal article (refereed), original research

The basis for strain-dependent rat aldehyde dehydrogenase 1A7 (ALDH1A7) gene expression

Touloupi, K; Kublbeck, J; Magklara, A; Molnar, F; Reinisalo, M; Konstandi, M; Honkakoski, P; Pappas, P, 2019, Molecular pharmacology, 96, 5, 655-663. A1 Journal article (refereed), original research

Functional Characterization of a Novel Variant of the Constitutive Androstane Receptor (CAR, NR1I3)

Prantner, Viktoria; Cinnamon, Yuval; Küblbeck, Jenni; Molnár, Ferdin; Honkakoski, Paavo, 2018, Nuclear Receptor Research, 5, 101386. A1 Journal article (refereed), original research

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity

Küblbeck Jenni, Hakkarainen Jenni J, Petsalo Aleksanteri, Vellonen Kati-Sisko, Tolonen Ari, Reponen Petri, Forsberg Markus M, Honkakoski Paavo, 2016, Journal of pharmaceutical sciences, 105, 2, 941-949. A1 Journal article (refereed), original research

Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models

Toivonen Sanna, Malinen Melina M, Küblbeck Jenni, Petsalo Aleksanteri, Urtti Arto, Honkakoski Paavo, Otonkoski Timo, 2016, Tissue engineering, 22, 13-14, 971-984. A1 Journal article (refereed), original research

Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons

Küblbeck Jenni, Zancanella Vanessa, Prantner Victoria, Molnár Ferdinand, Squires E. James, Dacasto Mauro, Honkakoski Paavo, Giantin Mery, 2015, Xenobiotica, 46 (2016), 3, 200-210. A1 Journal article (refereed), original research

Improved assays for xenosensor activation based on reverse transfection

Küblbeck Jenni, Anttila Teemu, Pulkkinen Juha T, Honkakoski Paavo, 2015, Toxicology in vitro, 29, 7, 1759-1765. A1 Journal article (refereed), original research

Regulation of bovine CYP3A28 promoter by pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

Giantin M., Zancanella V., Kueblbeck J., Prantner V., Sansonetti F., Honkakoski P., Dacasto M., 2015, Journal of veterinary pharmacology and therapeutics.

Direct and Rapid Transcript Analysis Assay for CYP mRNA Expression and Inducibility in Human Primary Hepatocytes

Mattinen Laura, Kublbeck Jenni, Rechardt Oona, Honkakoski Paavo, Rautio Jari, 2014, Drug metabolism letters, 8, 2, 77-87. A1 Journal article (refereed), original research

Lääkeaineiden metaboliaa ja kuljetusta säätelevät tumareseptorit

Honkakoski Paavo, Molnár Ferdinand, Kublbeck Jenni, 2014, Dosis, 30, 3, 193. B1 Non-refereed journal articles

Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator

Poutiainen Pekka K, Huhtala Tuulia, Jääskeläinen Tiina, Petsalo Aleksanteri, Küblbeck Jenni, Kaikkonen Sanna, Palvimo Jorma J, Raunio Hannu, Närvänen Ale, Peräkylä Mikael, Juvonen Risto O, Honkakoski Paavo, Laatikainen Reino, Pulkkinen Juha T, 2014, Molecular and cellular endocrinology, 387, 8-18. A1 Journal article (refereed), original research

An update on the constitutive androstane receptor (CAR)

Molnár Ferdinand, Küblbeck Jenni, Jyrkkärinne Johanna, Prantner Viktória, Honkakoski Paavo, 2013, Drug metabolism and drug interactions, 28, 2, 79-93. A2 Review article, Literature review, Systematic review

Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system

Pimkaew Prapapan, Küblbeck Jenni, Petsalo Aleksanteri, Jukka Jouni, Suksamrarn Apichart, Juvonen Risto, Auriola Seppo, Piyachaturawat Pawinee, Honkakoski Paavo, 2013, Toxicology in vitro, 27, 6, 2005-2012. A1 Journal article (refereed), original research

Characterization of human cytochrome P450 induction by pesticides

Abass Khaled, Lämsä Virpi, Reponen Petri, Küblbeck Jenni, Honkakoski Paavo, Mattila Sampo, Pelkonen Olavi, Hakkola Jukka, 2012, Toxicology, 294, 17-26. A1 Journal article (refereed), original research

Molecular dynamics simulations for human CAR inverse agonists

Jyrkkärinne Johanna, Küblbeck Jenni, Pulkkinen Juha, Honkakoski Paavo, Laatikainen Reino, Poso Antti, Laitinen Tuomo, 2012, Journal of chemical information and modeling, 52, 457-464. A1 Journal article (refereed), original research

Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system

Ma Liang, Barker Jeremy, Zhou Changchun, Li Wei, Zhang Jing, Lin Biaoyang, Foltz Gregory, Küblbeck Jenni, Honkakoski Paavo, 2012, Biomaterials, 33, 4353-4361. A1 Journal article (refereed), original research

New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists

Küblbeck Jenni, Jyrkkärinne Johanna, Molnár Ferdinand, Kuningas Tiina, Patel Jayendra, Windshügel Björn, Nevalainen Tapio, Laitinen Tuomo, Sippl Wolfgang, Poso Antti, Honkakoski Paavo, 2011, Molecular pharmaceutics, 8, 2424-2433. A1 Journal article (refereed), original research

Use of comprehensive screening methods to detect selective human CAR activators

Küblbeck Jenni, Laitinen Tuomo, Jyrkkärinne Johanna, Rousu Timo, Tolonen Ari, Abel Tobias, Kortelainen Tanja, Uusitalo Jouko, Korjamo Timo, Honkakoski Paavo, Molnár Ferdinand, 2011, Biochemical pharmacology, 82, 1994-2007. A1 Journal article (refereed), original research

Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors

Küblbeck J, Reinisalo M, Mustonen R & Honkakoski P, 2010, European journal of pharmaceutical sciences, 40, 263-272. A1 Journal article (refereed), original research

Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor

Küblbeck J, Jyrkkärinne J, Poso A, Turpeinen M, Sippl W, Honkakoski P, Windshügel B, 2008, Biochemical pharmacology, 76, 1288-1297. A1 Journal article (refereed), original research

Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship

Jyrkkärinne J, Windshügel B, Rönkkö T, Tervo AJ, Küblbeck J, Lahtela-Kakkonen M, Sippl W, Poso A, Honkakoski P, 2008, Journal of medicinal chemistry, 51, 7181-7192. A1 Journal article (refereed), original research

Comparison of homology models and X-ray structures of the nuclear receptor CAR: Assessing the structural basis of constitutive activity

Windshügel B, Jyrkkärinne J, Vanamo J, Poso A, Honkakoski P, Sippl W, 2007, Journal of molecular graphics and modelling, 25, 644-657. A1 Journal article (refereed), original research

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Metabolite-driven remodeling of hepatic lipid metabolism by the plasticizer di-isononyl phthalate

Activation of steroid hormone receptors by metabolism-disrupting chemicals

Association between phthalate exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) – systematic literature review

Drug-Free Approach to Regulate Undruggable Proto-Oncogene MYC Using Biomimetic Porous Nanoparticles for Cancer Immunotherapy

Look What You Made Me Do: Discerning Feature for Classification of Endocrine-Disrupting Chemical Binding to Steroid Hormone Receptors

Metabolic disruption by mycotoxins: focus on metabolic endpoints steatosis, adipogenesis and glucose metabolism in vivo and in vitro

Nuclear Receptors CAR and PXR as Cardiometabolic Regulators

Uncovering α-Selectivity for Liver X Receptor Agonists for Lipotoxic Cancer Therapies

Unmasking metabolic disruptors: The NEMESIS project's quest for Novel Biomarkers, Evidence on Adverse Effects, and Efficient Methodologies

Cancer Cells Show Higher Sensitivity to Melatonin-Tamoxifen Drug Conjugates than to Combination of Melatonin and Tamoxifen

The KEAP1-NRF2 pathway: Targets for therapy and role in cancer

Gefitinib-Tamoxifen Hybrid Ligands as Potent Agents against Triple-Negative Breast Cancer

Hormonihäirikköjä lautasella?

Profiling the regulatory interplay of BET bromodomains and Sirtuins in cancer cell lines

A toxicogenomic data space for system-level understanding and prediction of EDC-induced toxicity

Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells

Effects of galloflavin and ellagic acid on sirtuin 6 and its anti-tumorigenic activities

Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR

The EDCMET project: Metabolic effects of endocrine disruptors

A Reverse Transfection Method for Screening of Nuclear Receptor Activators

DNA elements for constitutive androstane receptor- and pregnane X receptor-mediated regulation of bovine CYP3A28 gene

Isoflavonien turvallisuus ja tutkimuksen haasteet

Metabolism of Scoparone in Experimental Animals and Humans

The basis for strain-dependent rat aldehyde dehydrogenase 1A7 (ALDH1A7) gene expression

Functional Characterization of a Novel Variant of the Constitutive Androstane Receptor (CAR, NR1I3)

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity

Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models

Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons

Improved assays for xenosensor activation based on reverse transfection

Regulation of bovine CYP3A28 promoter by pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

Direct and Rapid Transcript Analysis Assay for CYP mRNA Expression and Inducibility in Human Primary Hepatocytes

Lääkeaineiden metaboliaa ja kuljetusta säätelevät tumareseptorit

Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator

An update on the constitutive androstane receptor (CAR)

Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system

Characterization of human cytochrome P450 induction by pesticides

Molecular dynamics simulations for human CAR inverse agonists

Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system

New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists

Use of comprehensive screening methods to detect selective human CAR activators

Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors

Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor

Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship

Comparison of homology models and X-ray structures of the nuclear receptor CAR: Assessing the structural basis of constitutive activity