Johanna Kuusisto
Professor
Professor
Chief physician, Kuopio University Hospital Cardiologist, internist
Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences
Research groups
Publications
334/334 items-
Biomarkers reflecting insulin resistance increase the risk of aortic stenosis in a population-based study of 10,144 Finnish men
Sohlman, Maija; Jauhiainen, Raimo; Vangipurapu, Jagadish; Laakso, Annamaria; Ala-Korpela, Mika; Kuulasmaa, Teemu; Kuusisto, Johanna. 2024. Annals of medicine. 56: . 2419996 A1 Journal article (refereed), original research -
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Suzuki, Ken; Hatzikotoulas, Konstantinos; Southam, Lorraine; Taylor, Henry J.; Yin, Xianyong; Lorenz, Kim M.; Mandla, Ravi; Huerta-Chagoya, Alicia; Melloni, Giorgio E.M.; Kanoni, Stavroula; Rayner, Nigel W.; Bocher, Ozvan; Arruda, Ana Luiza; Sonehara, Kyuto; Namba, Shinichi; Lee, Simon S.K.; Preuss, Michael H.; Petty, Lauren E.; Schroeder, Philip; Vanderwerff, Brett; Kals, Mart; Bragg, Fiona; Lin, Kuang; Guo, Xiuqing; Zhang, Weihua; Yao, Jie; Kim, Young Jin; Graff, Mariaelisa; Takeuchi, Fumihiko. 2024. Nature. 627: 347-357 A1 Journal article (refereed), original research -
Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes
Wu, Ying-Chieh; Lehtonen, Šárka; Trontti, Kalevi; Kauppinen, Riitta; Kettunen, Pinja; Leinonen, Ville; Laakso, Markku; Kuusisto, Johanna; Hiltunen, Mikko; Hovatta, Iiris; Freude, Kristine; Dhungana, Hiramani; Koistinaho, Jari; Rolova, Taisia. 2024. Fluids and barriers of the cns. 21: . 78 A1 Journal article (refereed), original research -
Cell-type composition affects adipose gene expression associations with cardiometabolic traits
Brotman, Sarah M; Oravilahti, Anniina; Rosen, Jonathan D; Alvarez, Marcus; Heinonen, Sini; van der Kolk, Birgitta; Silva, Lilian Fernandes; Perrin, Hannah J; Vadlamudi, Swarooparani; Pylant, Cortney; Deochand, Sonia; Basta, Patricia V; Valone, Jordan M; Narain, Morgan N; Stringham, Heather M; Boehnke, Michael; Kuusisto, Johanna; Love, Michael I; Pietiläinen, Kirsi H; Pajukanta, Päivi; Laakso, Markku; Mohlke, Karen L. 2023. Diabetes. 72: 1707-1718 A1 Journal article (refereed), original research -
Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization
Willems, Sara M; Ng, Natasha H J; Fernandez, Juan; Fine, Rebecca S; Wheeler, Eleanor; Wessel, Jennifer; Kitajima, Hidetoshi; Marenne, Gaelle; Sim, Xueling; Yaghootkar, Hanieh; Wang, Shuai; Chen, Sai; Chen, Yuning; Chen, Yii-Der Ida; Grarup, Niels; Li-Gao, Ruifang; Varga, Tibor V; Asimit, Jennifer L; Feng, Shuang; Strawbridge, Rona J; Kleinbrink, Erica L; Ahluwalia, Tarunveer S; An, Ping; Appel, Emil V; Arking, Dan E; Auvinen, Juha; Bielak, Lawrence F; Bihlmeyer, Nathan A; Bork-Jensen, Jette; Bro. 2023. Wellcome open research. 8: A1 Journal article (refereed), original research -
Late-onset and classic phenotypes of Fabry disease in males with the GLA-Thr410Ala mutation
Valtola, Kati; Hedman, Marja; Kantola, Ilkka; Walls, Susanne; Helisalmi, Seppo; Maria, Maleeha; Raivo, Joose; Auray-Blais, Christiane; Kuusisto, Johanna. 2023. Open heart. 10: A1 Journal article (refereed), original research -
SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase
Kettunen, Pinja; Lesnikova, Angelina; Räsänen, Noora; Ojha, Ravi; Palmunen, Leena; Laakso, Markku; Lehtonen, Šárka; Kuusisto, Johanna; Pietiläinen, Olli; Saber, Saber H; Joensuu, Merja; Vapalahti, Olli P; Koistinaho, Jari; Rolova, Taisia; Balistreri, Giuseppe. 2023. Journal of virology. 97: . e00144-23 A1 Journal article (refereed), original research -
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
Ramdas, Shweta; Judd, Jonathan; Graham, Sarah E.; Kanoni, Stavroula; Wang, Yuxuan; Surakka, Ida; Wenz, Brandon; Clarke, Shoa L.; Chesi, Alessandra; Wells, Andrew; Bhatti, Konain Fatima; Vedantam, Sailaja; Winkler, Thomas W.; Locke, Adam E.; Marouli, Eirini; Zajac, Greg J.M.; Wu, Kuan-Han H.; Ntalla, Ioanna; Hui, Qin; Klarin, Derek; Hilliard, Austin T.; Wang, Zeyuan; Xue, Chao; Thorleifsson, Gudmar; Helgadottir, Anna; Gudbjartsson, Daniel F.; Holm, Hilma; Olafsson, Isleifur; Hwang, Mi Yeong; Han,. 2022. American journal of human genetics. 109: 1366-1387 A1 Journal article (refereed), original research -
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
Winkler, Thomas W.; Rasheed, Humaira; Teumer, Alexander; Gorski, Mathias; Rowan, Bryce X.; Stanzick, Kira J.; Thomas, Laurent F.; Tin, Adrienne; Hoppmann, Anselm; Chu, Audrey Y.; Tayo, Bamidele; Thio, Chris H. L.; Cusi, Daniele; Chai, Jin-Fang; Sieber, Karsten B.; Horn, Katrin; Li, Man; Scholz, Markus; Cocca, Massimiliano; Wuttke, Matthias; van der Most, Peter J.; Yang, Qiong; Ghasemi, Sahar; Nutile, Teresa; Li, Yong; Pontali, Giulia; Günther, Felix; Dehghan, Abbas; Correa, Adolfo; Parsa, Afshin. 2022. Communications biology. 5: A1 Journal article (refereed), original research -
Effects of age, amyloid, sex, and APOE epsilon 4 on the CSF proteome in normal cognition
Wesenhagen, Kirsten E. J.; Gobom, Johan; Bos, Isabelle; Vos, Stephanie J. B.; Martinez-Lage, Pablo; Popp, Julius; Tsolaki, Magda; Vandenberghe, Rik; Freund-Levi, Yvonne; Verhey, Frans; Lovestone, Simon; Streffer, Johannes; Dobricic, Valerija; Bertram, Lars; Blennow, Kaj; Pikkarainen, Maria; Hallikainen, Merja; Kuusisto, Johanna; Laakso, Markku; Soininen, Hilkka; Scheltens, Philip; Zetterberg, Henrik; Teunissen, Charlotte E.; Visser, Pieter Jelle; Tijms, Betty M.; for the Alzheimer’s Disease Neur. 2022. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 14: A1 Journal article (refereed), original research -
Genetic diversity fuels gene discovery for tobacco and alcohol use
Saunders, Gretchen R. B.; Wang, Xingyan; Chen, Fang; Jang, Seon-Kyeong; Liu, Mengzhen; Wang, Chen; Gao, Shuang; Jiang, Yu; Khunsriraksakul, Chachrit; Otto, Jacqueline M.; Addison, Clifton; Akiyama, Masato; Albert, Christine M.; Aliev, Fazil; Alonso, Alvaro; Arnett, Donna K.; Ashley-Koch, Allison E.; Ashrani, Aneel A.; Barnes, Kathleen C.; Barr, R. Graham; Bartz, Traci M.; Becker, Diane M.; Bielak, Lawrence F.; Benjamin, Emelia J.; Bis, Joshua C.; Bjornsdottir, Gyda; Blangero, John; Bleecker, Eug. 2022. Nature. 612: 720-724 A1 Journal article (refereed), original research -
Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies.
Gorski, Mathias; Rasheed, Humaira; Teumer, Alexander; Thomas, Laurent F.; Graham, Sarah E.; Sveinbjornsson, Gardar; Winkler, Thomas W.; Günther, Felix; Stark, Klaus J.; Chai, Jin-Fang; Tayo, Bamidele O.; Wuttke, Matthias; Li, Yong; Tin, Adrienne; Ahluwalia, Tarunveer S.; Ärnlöv, Johan; Åsvold, Bjørn Olav; Bakker, Stephan J.L.; Banas, Bernhard; Bansal, Nisha; Biggs, Mary L.; Biino, Ginevra; Böhnke, Michael; Boerwinkle, Eric; Bottinger, Erwin P.; Brenner, Hermann; Brumpton, Ben; Carroll, Robert J.. 2022. Kidney international. 102: 624-639 A1 Journal article (refereed), original research -
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Wang, Zhe; Emmerich, Andrew; Pillon, Nicolas J.; Moore, Tim; Hemerich, Daiane; Cornelis, Marilyn C.; Mazzaferro, Eugenia; Broos, Siacia; Ahluwalia, Tarunveer S.; Bartz, Traci M.; Bentley, Amy R.; Bielak, Lawrence F.; Chong, Mike; Chu, Audrey Y.; Berry, Diane; Dorajoo, Rajkumar; Dueker, Nicole D.; Kasbohm, Elisa; Feenstra, Bjarke; Feitosa, Mary F.; Gieger, Christian; Graff, Mariaelisa; Hall, Leanne M.; Haller, Toomas; Hartwig, Fernando P.; Hillis, David A.; Huikari, Ville; Heard-Costa, Nancy; Hol. 2022. Nature genetics. 54: 1332-1344 A1 Journal article (refereed), original research -
Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci
Yin, Xianyong; Chan, Lap Sum; Bose, Debraj; Jackson, Anne U; VandeHaar, Peter; Locke, Adam E; Fuchsberger, Christian; Stringham, Heather M; Welch, Ryan; Yu, Ketian; Fernandes Silva, Lilian; Service, Susan K; Zhang, Daiwei; Hector, Emily C; Young, Erica; Ganel, Liron; Das, Indraniel; Abel, Haley; Erdos, Michael R; Bonnycastle, Lori L; Kuusisto, Johanna; Stitziel, Nathan O; Hall, Ira M; Wagner, Gregory R; Ripatti, Samuli; Palotie, Aarno; Kang, Jian; Morrison, Jean; Burant, Charles F; Collins, Fran. 2022. Nature communications. 13: . 1644 A1 Journal article (refereed), original research -
Healthcare resource use of patients with transthyretin amyloid cardiomyopathy
Lauppe, Rosa; Liseth Hansen, Johan; Fornwall, Anna; Johansson, Katarina; Rozenbaum, Mark H; Strand, Anne Mette; Väkeväinen, Merja; Kuusisto, Johanna; Gude, Einar; Smith, J Gustav; Gustafsson, Finn. 2022. ESC heart failure. 9: 1636-1642 A1 Journal article (refereed), original research -
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Kanoni, Stavroula; Graham, Sarah E.; Wang, Yuxuan; Surakka, Ida; Ramdas, Shweta; Zhu, Xiang; Clarke, Shoa L.; Bhatti, Konain Fatima; Vedantam, Sailaja; Winkler, Thomas W.; Locke, Adam E.; Marouli, Eirini; Zajac, Greg J. M.; Wu, Kuan-Han H.; Ntalla, Ioanna; Hui, Qin; Klarin, Derek; Hilliard, Austin T.; Wang, Zeyuan; Xue, Chao; Thorleifsson, Gudmar; Helgadottir, Anna; Gudbjartsson, Daniel F.; Holm, Hilma; Olafsson, Isleifur; Hwang, Mi Yeong; Han, Sohee; Akiyama, Masato; Sakaue, Saori; Terao, Chika. 2022. Genome biology. 23: . 268 A1 Journal article (refereed), original research -
Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk
Yin, Xianyong; Bose, Debraj; Kwon, Annie; Hanks, Sarah C.; Jackson, Anne U.; Stringham, Heather M.; Welch, Ryan; Oravilahti, Anniina; Fernandes Silva, Lilian; Locke, Adam E.; Fuchsberger, Christian; Service, Susan K.; Erdos, Michael R.; Bonnycastle, Lori L.; Kuusisto, Johanna; Stitziel, Nathan O.; Hall, Ira M.; Morrison, Jean; Ripatti, Samuli; Palotie, Aarno; Freimer, Nelson B.; Collins, Francis S.; Mohlke, Karen L.; Scott, Laura J.; Fauman, Eric B.; Burant, Charles; Boehnke, Michael; Laakso, Ma. 2022. American journal of human genetics. 109: 1727-1741 A1 Journal article (refereed), original research -
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
Mahajan, Anubha; Spracklen, Cassandra N.; Zhang, Weihua; Ng, Maggie C. Y.; Petty, Lauren E.; Kitajima, Hidetoshi; Yu, Grace Z.; Rüeger, Sina; Speidel, Leo; Kim, Young Jin; Horikoshi, Momoko; Mercader, Josep M.; Taliun, Daniel; Moon, Sanghoon; Kwak, Soo-Heon; Robertson, Neil R.; Rayner, Nigel W.; Loh, Marie; Kim, Bong-Jo; Chiou, Joshua; Miguel-Escalada, Irene; della Briotta Parolo, Pietro; Lin, Kuang; Bragg, Fiona; Preuss, Michael H.; Takeuchi, Fumihiko; Nano, Jana; Guo, Xiuqing; Lamri, Amel; Nak. 2022. Nature genetics. 54: 560-572 A1 Journal article (refereed), original research -
Multiparametric platform for profiling lipid trafficking in human leukocytes
Pfisterer, Simon G; Brock, Ivonne; Kanerva, Kristiina; Hlushchenko, Iryna; Paavolainen, Lassi; Ripatti, Pietari; Islam, Mohammad Majharul; Kyttälä, Aija; Di Taranto, Maria D; Scotto di Frega, Annalisa; Fortunato, Giuliana; Kuusisto, Johanna; Horvath, Peter; Ripatti, Samuli; Laakso, Markku; Ikonen, Elina. 2022. Cell reports : methods. 2: A1 Journal article (refereed), original research -
Prevalence, characteristics, and mortality of patients with transthyretin amyloid cardiomyopathy in the Nordic countries
Lauppe, Rosa; Liseth Hansen, Johan; Fornwall, Anna; Johansson, Katarina; Rozenbaum, Mark H.; Strand, Anne Mette; Väkeväinen, Merja; Kuusisto, Johanna; Gude, Einar; Smith, J. Gustav; Gustafsson, Finn. 2022. ESC heart failure. 9: 2528-2537 A1 Journal article (refereed), original research -
Subcutaneous adipose tissue splice quantitative trait loci reveal differences in isoform usage associated with cardiometabolic traits
Brotman, Sarah M.; Raulerson, Chelsea K.; Vadlamudi, Swarooparani; Currin, Kevin W.; Shen, Qiujin; Parsons, Victoria A.; Iyengar, Apoorva K.; Roman, Tamara S.; Furey, Terrence S.; Kuusisto, Johanna; Collins, Francis S.; Boehnke, Michael; Laakso, Markku; Pajukanta, Päivi; Mohlke, Karen L.. 2022. American journal of human genetics. 109: 66-80 A1 Journal article (refereed), original research -
Uudet dyslipidemialääkkeet
Turunen, Kirsi; Kuusisto, Johanna. 2022. Lääkärilehti. 77: 1844-1846 D1 Article in a trade journal -
Association of structural variation with cardiometabolic traits in Finns
Chen, Lei; Abel, Haley J; Das, Indraniel; Larson, David E; Ganel, Liron; Kanchi, Krishna L; Regier, Allison A; Young, Erica P; Kang, Chul Joo; Scott, Alexandra J; Chiang, Colby; Wang, Xinxin; Lu, Shuangjia; Christ, Ryan; Service, Susan K; Chiang, Charleston WK; Havulinna, Aki S; Kuusisto, Johanna; Boehnke, Michael; Laakso, Markku et al.. 2021. American journal of human genetics. 108: 583-596 A1 Journal article (refereed), original research -
Cardiac Involvement in Fabry Disease
Pieroni, Maurizio; Moon, James C; Arbustini, Eloisa; Barriales-Villa, Roberto; Camporeale, Antonia; Vujkovac, Andreja Cokan; Elliott, Perry M; Hagege, Albert; Kuusisto, Johanna; Linhart, Ale¨; Nordbeck, Peter; Olivotto, Iacopo; Pietilä-Effati, Päivi; Namdar, Mehdi. 2021. Journal of the american college of cardiology. 77: 922-936 A2 Review article, Literature review, Systematic review -
Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes
Goodrich, JK; Singer-Berk, M; Son, R; Sveden, A; Wood, J; England, E; Cole, JB; Weisburd, B; Watts, N; Caulkins, L; Dornbos, P; Koesterer, R; Zappala, Z; Zhang, H; Maloney, KA; Dahl, A; Aguilar-Salinas, CA; Atzmon, G; Barajas-Olmos, F; Barzilai, N; et al; [incl. Kuusisto, J; Laakso, M]. 2021. Nature communications. 12: 3505 A1 Journal article (refereed), original research -
Machine Learning Reveals Time-Varying Microbial Predictors with Complex Effects on Glucose Regulation
Aasmets, Oliver; Lüll, Kreete; Lang, Jennifer M; Pan, Calvin; Kuusisto, Johanna; Fischer, Krista; Laakso, Markku; Lusis, Aldons J; Org, Elin. 2021. MSystems. 6: e-01191-20 A1 Journal article (refereed), original research -
Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids
Fagerlund, Ilkka; Dougalis, Antonios; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Pelkonen, Anssi; Konttinen, Henna; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Koskuvi, Marja; Kuusisto, Johanna; Hernández, Damián; Pebay, Alice; Koistinaho, Jari; Rauramaa, Tuomas; Lehtonen, ¦árka; Korhonen, Paula; Malm, Tarja. 2021. Cells. 2022; 11: 124 A1 Journal article (refereed), original research -
Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences
Ganel, Liron; Chen, Lei; Christ, Ryan; Vangipurapu, Jagadish; Young, Erica; Das, Indraniel; Kanchi, Krishna; Larson, David; Regier, Allison; Abel, Haley; Kang, Chul Joo; Scott, Alexandra; Havulinna, Aki; Chiang, Charleston WK; Service, Susan; Freimer, Nelson; Palotie, Aarno; Ripatti, Samuli; Kuusisto, Johanna; Boehnke, Michael; Laakso, Markku; Locke, Adam; Stitziel, Nathan O; Hall, Ira M. 2021. Human genomics. 15: 1-17 A1 Journal article (refereed), original research -
Nationwide prevalence and characteristics of transthyretin amyloid cardiomyopathy in Sweden
Lauppe, Rosa Elisabeth; Liseth Hansen, Johan; Gerdesköld, Christian; Rozenbaum, Mark H; Strand, Anne Mette; Vakevainen, Merja; Kuusisto, Johanna; Gude, Einar; Gustafsson, Finn; Smith, J Gustav. 2021. Open heart. 8: e001755 A1 Journal article (refereed), original research -
Rare coding variants in 35 genes associate with circulating lipid levels - A multi-ancestry analysis of 170,000 exomes
Hindy, George; Dornbos, Peter; Chaffin, Mark D.; Liu, Dajiang J.; Wang, Minxian; Selvaraj, Margaret Sunitha; Zhang, David; Park, Joseph; Aguilar-Salinas, Carlos A.; Antonacci-Fulton, Lucinda; Ardissino, Diego; Arnett, Donna K.; Aslibekyan, Stella; Atzmon, Gil; Ballantyne, Christie M.; Barajas-Olmos, Francisco; Barzilai, Nir; Becker, Lewis C.; Bielak, Lawrence F.; Bis, Joshua C. et al [incl. Kuusisto, Johanna; Laakso, Markku]. 2021. American journal of human genetics. 2022; 109: 81 - 96 A1 Journal article (refereed), original research -
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
Mägi, Reedik; Hottenga, Jouke- Jan; Grallert, Harald; Perry, John R. B.; Bouatia-Naji, Nabila; Marullo, Letizia; Rybin, Denis; Jansen, Rick; Min, Josine L.; Dimas, Antigone S.; Ulrich, Anna; Zudina, Liudmila; Gådin, Jesper R.; Jiang, Longda; Faggian, Alessia; Bonnefond, Amélie; Fadista, Joao; Stathopoulou, Maria G.; Isaacs, Aaron; Willems, Sara M et al. [incl. Kuusisto, Johanna; Laakso, Markku; Lakka, Timo, Uusitupa, Matti]. 2021. Nature communications. 12: 24 A1 Journal article (refereed), original research -
The association of nine amino acids with cardiovascular events in Finnish men in a 12-year follow-up study
Jauhiainen, Raimo; Vangipurapu, Jagadish; Laakso, Annamaria; Kuulasmaa, Teemu; Kuusisto, Johanna; Laakso, Markku. 2021. Journal of clinical endocrinology and metabolism. 106: 3448-3454 A1 Journal article (refereed), original research -
The power of genetic diversity in genome-wide association studies of lipids
Graham, Sarah E; Clarke, Shoa L; Wu, Kuan-Han H; Kanoni, Stavroula; Zajac, Greg JM; Ramdas, Shweta; Surakka, Ida; Ntalla, Ioanna; Vedantam, Sailaja; Winkler, Thomas W; Locke, Adam E; Marouli, Eirini; Hwang, Mi Yeong; Han, Sohee; Narita, Akira; Choudhury, Ananyo; Bentley, Amy R; Ekoru, Kenneth; Verma, Anurag; Trivedi, Bhavi [incl. Kuusisto, Johanna; Laakso, Markku]. 2021. Nature. 600: 675-679 A1 Journal article (refereed), original research -
The trans-ancestral genomic architecture of glycemic traits
Chen, J; Spracklen, CN; Marenne, G; Varshney, A; Corbin, LJ; Luan, J; Willems, SM; Wu, Y; Zhang, X; Horikoshi, M; Boutin, TS; Mägi, R; Waage, J; Li-Gao, R; Chan, KHK; Yao, J; Anasanti, MD; Chu, AY; Claringbould, A; Heikkinen, J; et al. [incl. Kuulasmaa, T; Kuusisto, J; Laakso, M; Lakka, T; Uusitupa, M; Vangipurapu, J]. 2021. Nature genetics. 53: 840-860 A1 Journal article (refereed), original research -
Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences
Spracklen, Cassandra N; Iyengar, Apoorva K; Vadlamudi, Swarooparani; Raulerson, Chelsea K; Jackson, Anne U; Brotman, Sarah M; Wu, Ying; Cannon, Maren E; Davis, James P; Crain, Aaron T; Currin, Kevin W; Perrin, Hannah J; Narisu, Narisu; Stringham, Heather M; Fuchsberger, Christian; Locke, Adam E; et al. [incl. Laakso, Markku]. 2020. PLoS genetics. 16: e1009019 A1 Journal article (refereed), original research -
Cardiomyopathy associated with the Ala143Thr variant of the α-galactosidase A gene
Valtola, K; Nino-Quintero, J; Hedman, M; Lottonen-Raikaslehto, L; Laitinen, T; Maria, M; Kantola, I; Naukkarinen, A; Laakso, M; Kuusisto, J. 2020. Heart. 106: 609-615 A1 Journal article (refereed), original research -
Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer's disease
Rolova, Taisia; Wu, Ying-Chieh; Koskuvi, Marja; Voutilainen, Jenni; Sonninen, Tuuli-Maria; Kuusisto, Johanna; Laakso, Markku; Hämäläinen, Riikka H; Koistinaho, Jari; Lehtonen, Sárka. 2020. Stem cell research. 48: 101968 A1 Journal article (refereed), original research -
Genetics of hypertrophic cardiomyopathy: what is the next step?
Kuusisto, Johanna. 2020. Heart. 106: 1291-1292 B1 Non-refereed journal articles -
Novel biomarkers associated with incident heart failure in 10 106 Finnish men
Jauhiainen, Raimo; Jauhiainen, Matti; Vangipurapu, Jagadish; Kuulasmaa, Teemu; Ala-Korpela, Mika; Laakso, Markku; Kuusisto, Johann. 2020. ESC heart failure. 2021; 8: 605-614 A1 Journal article (refereed), original research -
Rotation and torsion of the left ventricle with cardiovascular magnetic resonance tagging: comparison of two analysis methods
Lehmonen, Lauri; Jalanko, Mikko; Tarkiainen, Mika; Kaasalainen, Touko; Kuusisto, Johanna; Lauerma, Kirsi; Savolainen, Sauli. 2020. Bmc medical imaging. 20: 73 A1 Journal article (refereed), original research -
A catalog of genetic loci associated with kidney function from analyses of a million individuals
Wuttke; M; Li, Y; Li, M; Sieber, KB; Feitosa, MF; Gorski, M; Tin, A; Wang, L; Chu, AY; Hoppmann, A; Kirsten, H; Giri, A; Chai, JF; Sveinbjornsson, G; Tayo, BO; Nutile, T; Fuchsberger, C; Marten, J; et al. (incl. Kuusisto, J; Laakso, M). 2019. Nature genetics. 51: 957-972 A1 Journal article (refereed), original research -
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
Sung, Yun Ju; de Las Fuentes, Lisa; Winkler, Thomas W; Chasman, Daniel I; Bentley, Amy R; Kraja, Aldi T; Ntalla, Ioanna; Warren, Helen R; Guo, Xiuqing; Schwander, Karen; Manning, Alisa K; Brown, Michael R; Aschard, Hugues; Feitosa, Mary F; Franceschini, Nora; Lu, Yingchang; et al. (incl. Heikkinen, Sami; Kuusisto, Johanna; Laakso, Markku; Stancáková, Alena; Lakka, Timo A). 2019. Human molecular genetics. 28: 2615-2633 A1 Journal article (refereed), original research -
Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits
Raulerson, CK; Ko, A; Kidd, JC; Currin, KW; Brotman, SM; Cannon, ME; Wu, Y; Spracklen, CN; Jackson, AU; Stringham, HM; Welch, RP; Fuchsberger, C; Locke, AE; Narisu, N; Lusis, AJ; Civelek, M; Furey, TS; Kuusisto, J; Collins, FS; Boehnke, M; et al. [incl. Laakso, M]. 2019. American journal of human genetics. 105: 773-787 A1 Journal article (refereed), original research -
Associations of autozygosity with a broad range of human phenotypes
Clark, DW; Okada, Y; Moore, KHS; Mason, D; Pirastu, N; Gandin, I; Mattsson, H; Barnes, CLK; Lin, K; Zhao, JH; Deelen, P; Rohde, R; Schurmann, C; Guo, X; Giulianini, F; Zhang, W; Medina-Gomez, C; Karlsson, R; Bao, Y; Bartz, TM; et al. [incl. Kuusisto, J; Laakso, M; Vangipurapu, J; Yaluri, A]. 2019. Nature communications. 10: 4957 A1 Journal article (refereed), original research -
CMR derived left ventricular septal convexity in carriers of the hypertrophic cardiomyopathy-causing MYBPC3-Q1061X mutation
Tarkiainen, M; Sipola, P; Jalanko, M; Heliö, T; Jääskeläinen, P; Kivelä, K; Laine, M; Lauerma, K; Kuusisto, J. 2019. Scientific reports. 9: 5960 A1 Journal article (refereed), original research -
Circulating RNAs as predictive markers for the progression of type 2 diabetes
Ghai, V; Baxter, D; Wu, X; Kim, TK; Kuusisto, J; Laakso, M; Connolly, T; Li, Y; Andrade-Gordon, P; Wang, K. 2019. Journal of cellular and molecular medicine. 23: 2753-2768 A1 Journal article (refereed), original research -
Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution
Wu, Y; Broadaway, KA; Raulerson, CK; Scott, LJ; Pan, C; Ko, A; He, A; Tilford, C; Fuchsberger, C; Locke, AE; Stringham, HM; Jackson, AU; Narisu, N; Kuusisto, J; Pajukanta, P; Collins, FS; Boehnke, M; Laakso, M; Lusis, AJ; Civelek, M; et al.. 2019. Human molecular genetics. 28: 4161-4172 A1 Journal article (refereed), original research -
Disentangling the genetics of lean mass
Karasik, D; Zillikens, MC; Hsu, YH; Aghdassi, A; Akesson, K; Amin, N; Barroso, I; Bennett, DA; Bertram, L; Bochud, M; Borecki, IB; Broer, L; Buchman, AS; Byberg, L; Campbell, H; Campos-Obando, N; Cauley, JA; Cawthon, PM; Chambers, JC; Chen, Z; et al. (incl. Kuulasmaa, Teemu; Kuusisto, Johanna; Laakso, Markku). 2019. American journal of clinical nutrition. 109: 276-287 A1 Journal article (refereed), original research -
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls
Flannick, J; Mercader, JM; Fuchsberger, C; Udler, MS; Mahajan, A; Wessel, J; Teslovich, TM; Caulkins, L; Koesterer, R; Barajas-Olmos, F; Blackwell, TW; Boerwinkle, E; Brody, JA; Centeno-Cruz, F; Chen, L; Chen, S; Contreras-Cubas, C; Córdova, E; et al. (incl. Kuusisto, J; Laakso, M). 2019. Nature. 570: 71-76 A1 Journal article (refereed), original research -
Fabry-kardiomyopatia
Kantola, Ilkka; Kuusisto, Johanna. 2019. Sydänääni. 30: 161-169 D1 Article in a trade journal -
Genetic basis and outcome in a nationwide study of Finnish patients with hypertrophic cardiomyopathy
Jääskeläinen, P; Vangipurapu, J; Raivo, J; Kuulasmaa, T; Heliö, T; Aalto-Setälä, K; Kaartinen, M; Ilveskoski, E; Vanninen, S; Hämäläinen, L; Melin, J; Kokkonen, J; Nieminen, MS; FinHCM Study Group; Laakso, M; Kuusisto, J. 2019. ESC heart failure. 6: 436-445 A1 Journal article (refereed), original research -
Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
de Vries, PS; Brown, MR; Bentley, AR; Sung, YJ; Winkler, TW; Ntalla, I; Schwander, K; Kraja, AT; Guo, X; Franceschini, N; Cheng, CY; Sim, X; Vojinovic, D; Huffman, JE; Musani, SK; Li, C; Feitosa, MF; Richard, MA; Noordam, R; Aschard, H; et al. (Incl. Kuusisto, Johanna; Laakso, Markku; Lakka, Timo; Heikkinen, Sami). 2019. American journal of epidemiology. 188: 1033-1054 A1 Journal article (refereed), original research -
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
Bentley, AR; Sung, YJ; Brown, MR; Winkler, TW; Kraja, AT; Ntalla, I; Schwander, K; Chasman, DI; Lim, E; Deng, X; Guo, X; Liu, J; Lu, Y; Cheng, CY; Sim, X; Vojinovic, D; Lakka, TA; Heikkinen, S; Kuusisto, J; Laakso, M; et al. (incl. Laakso, Markku; Heikkinen, Sami; Kuusisto, Johanna; Lakka, Timo; Rauramaa, Rainer). 2019. Nature genetics. 51: 636-648 A1 Journal article (refereed), original research -
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
Kilpeläinen, TO; Bentley, AR; Noordam, R; Sung, YJ; Schwander, K; Winkler, TW; Jakupovic, H; Chasman, DI; Manning, A; Ntalla, I; Aschard, H; Brown, MR; de Las Fuentes, L; Franceschini, N; Guo, X; Vojinovic, D; Aslibekyan, S; Feitosa, MF; Kho, M; Musani, SK; et al. [Incl. Lakka, Timo; Heikkinen, Sami; Kuusisto, Johanna; Laakso, Markku]. 2019. Nature communications. 10: 376 A1 Journal article (refereed), original research -
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Evangelou E; Gao, H; Chu, C; Ntritsos, G; Blakeley, P; Butts, AR; Pazoki, R; Suzuki, H; Koskeridis, F; Yiorkas, AM; Karaman, I; Elliott, J; Luo, Q; Aeschbacher, S; Bartz, TM; Baumeister, SE; Braund, PS; Brown, MR; Brody, JA; Clarke TK; et al. (Incl. Yaluri, A; Kuusisto, J; Laakso, M; Vangipurapu, J). 2019. Nature human behaviour. 3: 950-961 A1 Journal article (refereed), original research -
Nine Amino Acids are Associated with Decreased Insulin Secretion and Elevated Glucose Levels in a 4.6-Year Follow-Up Study of 5,181 Finnish Men
Vangipurapu, J; Stancáková, A; Smith, U; Kuusisto, J; Laakso, M. 2019. Diabetes. 68: 1353-1358 A1 Journal article (refereed), original research -
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
Justice, AE; Karaderi, T; Highland, HM; Young, KL; Graff, M; Lu, Y; Turcot, V; Auer, PL; Fine, RS; Guo, X; Schurmann, C; Lempradl, A; Marouli, E; Mahajan, A; Winkler, TW; Locke, AE; Medina-Gomez, C; Esko, T; Vedantam, S; Giri, A; Lo, KS; et al. (Incl. Kuusisto, Johanna; Laakso, Markku; Lakko, Timo; Uusitupa, Matti; Vanhala, Mauno). 2019. Nature genetics. 51: 452-469 A1 Journal article (refereed), original research -
A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression
Kycia, I; Wolford, BN; Huyghe, JR; Fuchsberger, C; Vadlamudi, S; Kursawe, R; Welch, RP; Albanus, RD; Uyar, A; Khetan, S; Lawlor, N; Bolisetty, M; Mathur, A; Kuusisto, J; Laakso, M; Ucar, D; Mohlke, KL; Boehnke, M; Collins, FS; Parker, SCJ; et al.. 2018. American journal of human genetics. 102: 620-635 A1 Journal article (refereed), original research -
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
Sung, YJ; Winkler, TW; de Las Fuentes, L; Bentley, AR; Brown, MR; Kraja, AT; Schwander, K; Ntalla, I; Guo, X; Franceschini, N; Lu, Y; Cheng, CY; Sim, X; Vojinovic, D; Marten, J; Musani, SK; Li, C; Feitosa, MF; Kilpeläinen, TO; Richard, MA et al. (incl. Yaluri, Alena; Heikkinen, Sami; Kuusisto, Johanna; Laakso, Markku). 2018. American journal of human genetics. 102: 375-400 A1 Journal article (refereed), original research -
A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study
Latva-Rasku, A; Honka, MJ; Stancáková, A; Koistinen, HA; Kuusisto, J; Guan, L; Manning, AK; Stringham, H; Gloyn, AL; Lindgren, CM; T2D-GENES Consortium; Collins, FS; Mohlke, KL; Scott, LJ; Karjalainen, T; Nummenmaa, L; Boehnke, M; Nuutila, P; Laakso, M. 2018. Diabetes. 67: 334-342 A1 Journal article (refereed), original research -
Akuuttia sisämedisiinaa tarvitaan
Kuusisto, Johanna; Kaukinen, Katri; Kaaja, Risto. 2018. Lääkärilehti. 73: 1562 D1 Article in a trade journal -
Decreased plasma C-reactive protein levels in APOE E 4 allele carriers
Martiskainen, Henna; Takalo, Mari; Solomon, Alina; Stancáková, Alena; Marttinen, Mikael; Natunen, Teemu; Haapasalo, Annakaisa; Herukka, Sanna-Kaisa; Kuusisto, Johanna; Soininen, Hilkka; Kivipelto, Miia; Laakso, Markku; Hiltunen, Mikko. 2018. Annals of clinical and translational neurology. 5: 1229-1240 A1 Journal article (refereed), original research -
Epigenome-wide association in adipose tissue from the METSIM cohort
Orozco, Luz D; Farrell, Colin; Hale, Christopher; Rubbi, Liudmilla; Rinaldi, Arturo; Civelek, Mete; Pan, Calvin; Lam, Larry; Montoya, Dennis; Edillor, Chantle; Seldin, Marcus; Boehnke, Michael; Mohlke, Karen L; Jacobsen, Steve; Kuusisto, Johanna; Laakso, Markku; Lusis, Aldons J; Pellegrini, Matteo. 2018. Human molecular genetics. 27: 1830-1846 A1 Journal article (refereed), original research -
Fibrosis and wall thickness affect ventricular repolarization dynamics in hypertrophic cardiomyopathy
Jalanko, M; Väänänen, H; Tarkiainen, M; Sipola, P; Jääskeläinen, P; Lauerma, K; Laitinen, T; Laitinen, T; Laine, M; Heliö, T; Kuusisto, J; Viitasalo, M. 2018. Annals of noninvasive electrocardiology. 23: e12582 A1 Journal article (refereed), original research -
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
Mahajan, A; Taliun, D; Thurner, M; Robertson, NR; Torres, JM; Rayner, NW; Payne, AJ; Steinthorsdottir, V; Scott, RA; Grarup, N; Cook, JP; Schmidt, EM; Wuttke, M; Sarnowski, C; Mägi, R; Nano, J; Gieger, C; Trompet, S; Lecoeur, C; Preuss, MH; et al (Incl. Laakso, Markku; Kuusisto, Johanna; Yaluri, Alena). 2018. Nature genetics. 50: 1505-1512 A1 Journal article (refereed), original research -
Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia
López Rodríguez, Maykel; Fernandes Silva, Lilian; Vangipurapu, Jagadish; Modi, Shalem; Kuusisto, Johanna; Kaikkonen, Minna U; Laakso, Markku. 2018. Scientific reports. 8: 15989 A1 Journal article (refereed), original research -
Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease
Lehtonen, S; Höytyläinen, I; Voutilainen, J; Sonninen, T-M; Kuusisto, J; Laakso, M; Hämäläinen, RH; Oksanen, M; Koistinaho, J. 2018. Stem cell research. 30: 96-99 A1 Journal article (refereed), original research -
Genetiikka
Heliö, Tiina; Kuusisto, Johanna. 2018. Sydänääni. 29: 199-202 D1 Article in a trade journal -
Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study
Teslovich, Tanya M; Kim, Daniel Seung; Yin, Xianyong; Stancakova, Alena; Jackson, Anne U; Wielscher, Matthias; Naj, Adam; Perry, John R B; Huyghe, Jeroen R; Stringham, Heather M; Davis, James P; Raulerson, Chelsea K; Welch, Ryan P; Fuchsberger, Christian; Locke, Adam E; Sim, Xueling; Chines, Peter S; Narisu, Narisu; Kangas, Antti J; Soininen, Pasi; et al (incl. Yaluri, Alena; Ala-Korpela, Mika; Kuusisto, Johanna; Laakso, Markku; Soininen, Pasi). 2018. Human molecular genetics. 27: 1664-1674 A1 Journal article (refereed), original research -
Novel electrocardiographic features in carriers of hypertrophic cardiomyopathy causing sarcomeric mutations
Jalanko, Mikko; Heliö, Tiina; Mustonen, Pirjo; Kokkonen, Jorma; Huhtala, Heini; Laine, Mika; Jääskeläinen, Pertti; Tarkiainen, Mika; Lauerma, Kirsi; Sipola, Petri; Laakso, Markku; Kuusisto, Johanna; Nikus, Kjell. 2018. Journal of electrocardiology. 51: 983-989 A1 Journal article (refereed), original research -
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
Feitosa, MF; Kraja, AT; Chasman, DI; Sung, YJ; Winkler, TW; Ntalla, I; Guo, X; Franceschini, N; Cheng, CY; Sim, X; Vojinovic, D; Marten, J; Musani, SK; Li, C; Bentley, AR; Brown, MR; Schwander, K; Richard, MA; Noordam, R; Aschard, H; et al. (incl. Laakso, Markku; Heikkinen, Sami; Kuusisto, Johanna; Lakka, Timo; Yaluri, Alena). 2018. PLoS ONE. 13: e0198166 A1 Journal article (refereed), original research -
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
Mahajan, A; Wessel, J; Willems, SM; Zhao, W; Robertson, NR; Chu, AY; Gan, W; Kitajima, H; Taliun, D; Rayner, NW; Guo, X; Lu, Y; Li, M; Jensen, RA; Hu, Y; Huo, S; Lohman, KK; Zhang, W; Cook, JP; Prins, BP; et al. (Incl. Laakso, Markku; Kuusisto, Johanna; Yaluri, Alena). 2018. Nature genetics. 50: 559-571 A1 Journal article (refereed), original research -
Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling
Koivumäki, Jussi T; Naumenko, Nikolay; Tuomainen, Tomi; Takalo, Jouni; Oksanen, Minna; Puttonen, Katja A; Lehtonen, Sarka; Kuusisto, Johanna; Laakso, Markku; Koistinaho, Jari; Tavi, Pasi. 2018. Frontiers in physiology. 9: 80 A1 Journal article (refereed), original research -
Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans
Lin, LY; Chun-Chang, S; O'Hearn, J; Hui, ST; Seldin, M; Gupta, P; Bondar, G; Deng, M; Jauhiainen, R; Kuusisto, J; Laakso, M; Sinsheimer, JS; Deb, A; Rau, C; Ren, S; Wang, Y; Lusis, AJ; Wang, JJ; Huertas-Vazquez, A. 2018. G3: genes, genomes, genetics. 8: 3499-3506 A1 Journal article (refereed), original research -
A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the Adcy5 Locus
Roman TS, Cannon ME, Vadlamudi S, Buchkovich ML, Wolford BN, Welch RP, Morken MA, Kwon GJ, Varshney A, Kursawe R, Wu Y, Jackson AU, Erdos MR, Kuusisto J, Laakso M, Scott LJ, Boehnke M, Collins FS, Parker SCJ, Stitzel ML, Mohlke KL. 2017. Diabetes. 66: 2521-2530 A1 Journal article (refereed), original research -
Clinical disease presentation and ECG characteristics of LMNA mutation carriers
Ollila L, Nikus K, Holmström M, Jalanko M, Jurkko R, Kaartinen M, Koskenvuo J, Kuusisto J, Kärkkäinen S, Palojoki E, Reissell E, Piirilä P, Heliö T. 2017. Open heart. 4: e000474 A1 Journal article (refereed), original research -
Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study
Davis JP, Huyghe JR, Locke AE, Jackson AU, Sim X, Stringham HM, Teslovich TM, Welch RP, Fuchsberger C, Narisu N, Chines PS, Kangas AJ, Soininen P, Ala-Korpela M, Kuusisto J, Collins FS, Laakso M, Boehnke M, Mohlke KL. 2017. PLoS genetics. 13: e1007079 A1 Journal article (refereed), original research -
Decreased plasma ß-amyloid in the Alzheimer's disease APP A673T variant carriers
Martiskainen H, Herukka SK, Stancáková A, Paananen J, Soininen H, Kuusisto J, Laakso M, Hiltunen M. 2017. Annals of neurology. 82: 128-132 A1 Journal article (refereed), original research -
Diabetes secondary to treatment with statins
Laakso Markku, Kuusisto Johanna. 2017. Current diabetes reports. 17: 1-9 A2 Review article, Literature review, Systematic review -
Differential Associations of Inflammatory Markers With Insulin Sensitivity and Secretion: The Prospective METSIM Study
Fizelova M, Jauhiainen R, Kangas AJ, Soininen P, Ala-Korpela M, Kuusisto J, Laakso M, Stancáková A. 2017. Journal of clinical endocrinology and metabolism. 102: 3600-3609 A1 Journal article (refereed), original research -
Exome-wide association study of plasma lipids in >300,000 individuals
Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, Di Angelantonio E, Arveiler D, Assimes TL, Auer PL, Baber U, Ballantyne CM, Bang LE, Benn M, Bis JC et al.. 2017. Nature genetics. 49: 1758-1766 A1 Journal article (refereed), original research -
Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits
Civelek M, Wu Y, Pan C, Raulerson CK, Ko A, He A, Tilford C, Saleem NK, Stancáková A, Scott LJ, Fuchsberger C, Stringham HM, Jackson AU, Narisu N, Chines PS, Small KS, Kuusisto J, Parks BW, Pajukanta P, Kirchgessner T et al. 2017. American journal of human genetics. 100: 428-443 A1 Journal article (refereed), original research -
Genetic risk scores in the prediction of plasma glucose, impaired insulin secretion, insulin resistance and incident type 2 diabetes in the METSIM study
Stancakova Alena, Kuulasmaa Teemu, Kuusisto Johanna, Mohlke Karen L, Collinis Francis S, Boehnke Michael, Laakso Markku. 2017. Diabetologia. 60: 1722-1730 A1 Journal article (refereed), original research -
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Justice Anne E, Winkler Thomas W, Feitosa Mary F, Graff Misa, Fisher Virginia A, Young Kristin, Barata Llilda, Deng Xuan, Czajkowski Jacek, Hadley David, Ngwa Julius S, Ahluwalia Tarunveer S, Chu Audrey Y, Heard-Costa Nancy L, Lim Elise, Perez Jeremiah, Eicher John D, Kutalik Zoltan, Xue Luting, Mahajan Anubha et al.. 2017. Nature communications. 8: 14977 A1 Journal article (refereed), original research -
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults
Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, Xue L, Workalemahu T, Heard-Costa NL, den Hoed M, Ahluwalia TS, Qi Q, Ngwa JS, Renström F, Quaye L, Eicher JD et al.. 2017. PLoS genetics. 13: e1006528 A1 Journal article (refereed), original research -
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
Wheeler E, Leong A, Liu CT, Hivert MF, Strawbridge RJ, Podmore C, Li M, Yao J, Sim X, Hong J, Chu AY, Zhang W, Wang X, Chen P, Maruthur NM, Porneala BC, Sharp SJ, Jia Y, Kabagambe EK, Chang LC et al. (incl. Kuusisto J, Laakso M). 2017. PLoS ONE. 14: 1002383 A1 Journal article (refereed), original research -
Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study
de Mello VD, Paananen J, Lindstrom J, Lankinen MA, Shi L, Kuusisto J, Pihlajamaki J, Auriola S, Lehtonen M, Rolandsson O, Bergdahl IA, Nordin E, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Landberg R, Eriksson JG, Tuomilehto J, Hanhineva K, Uusitupa M. 2017. Scientific reports. 7: 46337 A1 Journal article (refereed), original research -
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
Zillikens M Carola, Demissie Serkalem, Hsu Yi-Hsiang, Yerges-Armstrong Laura M, Chou Wen-Chi, Stolk Lisette, Livshits Gregory, Broer Linda, Johnson Toby, Koller Daniel L, Kutalik Zoltán, Luan Jian'an, Malkin Ida, Ried Janina S, Smith Albert V, Thorleifsson Gudmar, Vandenput Liesbeth, Zhao Jing Hua, Zhang Weihua, Aghdassi Ali et al. (incl. Cederberg Henna, Kuulasmaa Teemu, Kuusisto Johanna, Laakso Markku, Alena Stancáková). 2017. Nature communications. 8: 80 A1 Journal article (refereed), original research -
Lipidome as a predictive tool in progression to type 2 diabetes in Finnish men
Suvitaival T, Bondia-Pons I, Yetukuri L, Pöhö P, Nolan JJ, Hyötyläinen T, Kuusisto J, Ore¨ic M. 2017. Metabolism: clinical and experimental. 2018; 78: 1-12 A1 Journal article (refereed), original research -
Novel association of TM6SF2 rs58542926 genotype with increased serum tyrosine levels and decreased apoB-100 particles in Finns
Kim DS, Jackson AU, Li YK, Stringham HM, FinMetSeq Investigators, Kuusisto J, Kangas AJ, Soininen P, Ala-Korpela M, Burant CF, Salomaa V, Boehnke M, Laakso M, Speliotes EK. 2017. Journal of lipid research. 58: 1471-1481 A1 Journal article (refereed), original research -
Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease
Mardinoglu Adil, Stancáková Alena, Lotta Luca A, Kuusisto Johanna, Boren Jan, Blüher Matthias, Wareham Nicholas J, Ferrannini Ele, Groop Per Henrik, Laakso Markku, Langenberg Claudia, Smith Ulf. 2017. Cell metabolism. 26: 281-283 B1 Non-refereed journal articles -
Predicting glycated hemoglobin levels in the non-diabetic general population: Development and validation of the DIRECT - DETECT prediction model - a DIRECT study
Rauh Simone P, Heymans Martijn W, Koopman Anitra DM, Nijpels Giel, Stehouwer Coen D, Thorand Barbara, Rathmann Wolfgang, Meisinger Christa, Peters Annette, de las Heras Gala Tonia, Glümer Charlotte, Pedersen Olut, Cederberg Henna, Kuusisto Johanna, Laakso Markku, Pearson Ewan R, Franks Paul W, Rutters Femke, Dekker Jacqueline M. 2017. PLoS ONE. 12: e0171816 A1 Journal article (refereed), original research -
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T et al. (incl. Laakso Markku, Lakka Timo, Uusitupa Matti). 2017. Nature genetics. 50; 2018: 26-41 A1 Journal article (refereed), original research -
Rare and low-frequency coding variants alter human adult height
Marouli Eirini, Graff Mariaelisa, Medina-Gomez Carolina, Sin Lo Ken, Wood Andrew R, Kjaer Troels R, Fine Rebecca S, Lu Yingchang, Schurmann Claudia, Highland Heather M, Rüeger Sina, Thorleifsson Gudmar, Justice Anne E, Lamparter David, Stirrups Kathleen E, Turcot Valérie, Young Kristin L, Winkler Thomas W, Esko Tõnu, Karaderi Tugce et al. (incl Kuusisto Johanna, Laakso Markku, Lakka Timo A). 2017. Nature. 542: 186-190 A1 Journal article (refereed), original research -
Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort
Org E, Blum Y, Kasela S, Mehrabian M, Kuusisto J, Kangas AJ, Soininen P, Wang ZN, Ala-Korpela M, Hazen SL, Laakso M, Lusis AJ. 2017. Genome biology. 18: 70 A1 Journal article (refereed), original research -
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Jason F, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Tajes JF et al. (incl. Kuulasmaa Teemu, Kuusisto Johanna, Laakso Markku). 2017. Scientific data. 4: 170179 A1 Journal article (refereed), original research -
The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases
Laakso Markku, Kuusisto Johanna, Stancakova Alena, Kuulasmaa Teemu, Pajukanta Päivi, Jake Lusis Aldons, Collins Francis S, Mohlke Karen, Boehnke Michael. 2017. Journal of lipid research. 58: 481-493 A1 Journal article (refereed), original research -
The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology
Westwood S, Liu B, Baird AL, Anand S, Nevado-Holgado AJ, Newby D, Pikkarainen M, Hallikainen M, Kuusisto J, Streffer JR, Novak G, Blennow K, Andreasson U, Zetterberg H, Smith U, Laakso M, Soininen H, Lovestone S. 2017. Alzheimer's research and therapy. 9: 31 A2 Review article, Literature review, Systematic review -
Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus
Cannon ME, Duan Q, Wu Y, Zeynalzadeh M, Xu Z, Kangas AJ, Soininen P, Ala-Korpela M, Civelek M, Lusis AJ, Kuusisto J, Collins FS, Boehnke M, Tang H, Laakso M, Li Y, Mohlke K. 2017. G3: genes, genomes, genetics. 7: 3217-3227 A1 Journal article (refereed), original research -
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease
Scott Robert A, Freitag Daniel F, Li Li, Chu Audrey Y, Surendran Praveen, Young Robin, Grarup Niels, Stancáková Alena, Chen Yuning, Varga Tibor V, Yaghootkar Hanieh, Luan Jian'an, Zhao Jing Hua, Willems Sara M, Wessel Jennifer, Wang Shuai, Maruthur Nisa, Michailidou Kyriaki, Pirie Ailith, van der Lee Sven J et al. 2016. Science translational medicine. 8: pp. 341ra76 A1 Journal article (refereed), original research -
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G, Eklund N, Eriksson J, Esko T, Feitosa MF, Goel A, Gorski M, Hayward C, Heard-Costa NL, Jackson AU, Jokinen E, Kanoni S, Kristiansson K et al. 2016. Nature communications. 7: 13357 A1 Journal article (refereed), original research -
Cardiovascular magnetic resonance of mitral valve length in hypertrophic cardiomyopathy
Tarkiainen Mika, Sipola Petri, Jalanko Mikko, Heliö Tiina, Laine Mika, Järvinen Vesa, Häyrinen Kaisu, Lauerma Kirsi, Kuusisto Johanna. 2016. Journal of cardiovascular magnetic resonance. 18: 33 A1 Journal article (refereed), original research -
Current perspectives in hypertrophic cardiomyopathy with the focus on patients in the Finnish population: a review
Kuusisto Johanna, Sipola Petri, Jääskeläinen Pertti, Naukkarinen Anita. 2016. Annals of medicine. [Epub ahead of print 27 Jul 2016]: 1-13 A2 Review article, Literature review, Systematic review -
Deleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy
West Gun, Gullmets Josef, Virtanen Laura, Li Song-Ping, Keinänen Anni, Shimi Takeshi, Mauermann Monika, Heliö Tiina, Kaartinen Maija, Ollila Laura, Kuusisto Johanna, Eriksson John E., Goldman Robert D., Herrmann Harald, Taimen Pekka. 2016. Journal of cell science. 129: 2732-2743 A1 Journal article (refereed), original research -
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index
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Walle Paula, Takkunen Markus, Männistö Ville, Vaittinen Maija, Lankinen Maria, Kärjä Vesa, Käkelä Pirjo, Ågren Jyrki, Tiainen Mika, Schwab Ursula, Kuusisto Johanna, Laakso Markku, Pihlajamäki Jussi. 2016. Metabolism: clinical and experimental. 65: 655-666 A1 Journal article (refereed), original research -
Finnish Diabetes Risk Score Is Associated with Impaired Insulin Secretion and Insulin Sensitivity, Drug-Treated Hypertension and Cardiovascular Disease: A Follow-Up Study of the METSIM Cohort
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Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Pattaro Christian, Teumer Alexander, Gorski Mathias, Chu Audrey Y, Li Man, Mijatovic Vladan, Garnaas Maija, Tin Adrienne, Sorice Rossella, Li Yong, Taliun Daniel, Olden Matthias, Foster Meredith, Yang Qiong, Chen Ming-Huei, Pers Tune H, Johnson Andrew D, Ko Yi-An, Fuchsberger Christian, Tayo Bamiele et al.. 2016. Nature communications. 7: 10023 A1 Journal article (refereed), original research -
Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci
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Gusev Alexander, Ko Arthur, Shi Huwendo, Bhatia Gaurav, Chung Wonil, Penninx Brenda WJH, Jansen Rick, de Geus Eco JC, Boomsma Dorret I, Wright Fred A, Sullivan Patrick F, Nikkola Elina, Alvarez Marcus, Civelek Mete, Lusis Aldons J, Lehtimäki Terho, Raitoharju Emma, Kähönen Mika, Seppälä Ilkka, Raitakari Olli T et al. 2016. Nature genetics. 48: 245-252 A1 Journal article (refereed), original research -
Left ventricular mechanical dispersion is associated with nonsustained ventricular tachycardia in hypertrophic cardiomyopathy
Jalanko Mikko, Tarkiainen Mika, Sipola Petri, Jääskeläinen Pertti, Lauerma Kirsi, Laine Mika, Nieminen Markku S, Laakso Markku, Heliö Tiina, Kuusisto Johanna. 2016. Annals of medicine. : 2016 Jun 1:1-11. [Epub ahead of print] A1 Journal article (refereed), original research -
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Lu Yingchang, Day Felix R, Gustafsson Stefan, Buchkovich Martin L, Na Jianbo, Bataille Veronique, Cousminer Diana L, Dastani Zari, Drong Alexander W, Esko Tönu, Evans David M, Falchi Mario, Feitosa Mary F, Ferreira Teresa, Hedman Åsa K, Haring Robin, Hysi Pirro G, Iles Mark M, Justice Anne E, Kanoni Stavroula et al. 2016. Nature communications. 7: 10495 A1 Journal article (refereed), original research -
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease
Zanoni Paolo, Khetarpal Sumeet A, Larach Daniel B, Hancock-Cerutti William F, Millar John S, Cuchel Marina, DerOhannessian Stephanie, Kontush Anatol, Surendran Praveen, Saleheen Danish, Trompet Stella, Jukema J Wouter, De Craen Anton, Deloukas Panos, Sattar Naveed, Ford Ian, Packard Chris, Majumder Abdullah al Shafi , Alam Dewan S, Di Angelantonio Emanuele et al. 2016. Science. 351: 1166-1171 A1 Journal article (refereed), original research -
Regulation of alternative splicing in human obesity loci
Kaminska Dorota, Käkelä Pirjo, Nikkola Elina, Venesmaa Sari, Ilves Imre, Herzig Karl-Heinz, Kolehmainen Marjukka, Karhunen Leila, Kuusisto Johanna, Gylling Helena, Pajukanta Päivi, Laakso Markku, Pihlajamäki Jussi. 2016. Obesity. 24: 2033-2037 A1 Journal article (refereed), original research -
Short adult stature predicts impaired beta-cell function, insulin resistance, glycemia and type 2 diabetes in Finnish men
Vangipurapu Jagadish, Stancakova Alena, Jauhiainen Raimo, Kuusisto Johanna, Laakso Markku. 2016. Journal of clinical endocrinology and metabolism. 2017: 102: 443-450 A1 Journal article (refereed), original research -
The genetic architecture of type 2 diabetes
Fuchsberger Christian, Flannick Jason, Teslovich Tanya M, Mahajan Anubha, Agarwala Vineeta, Gaulton Kyle J, Ma Clement, Fontanillas Pierre, Moutsianas Loukas, McCarthy Davis J, Rivas Manuel A, Perry John RB, Sim Xueling, Blackwell Thomas W, Robertson Neil R, Rayner N William, Cingolani Pablo, Locke Adam E, Tajes Juan Fernandes, Highland Heather M, (incl Kuulasmaa Teemu). 2016. Nature. 536: 41-47 A1 Journal article (refereed), original research -
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Ehret GB, Ferreira T, Chasman DI, Jackson AU, Schmidt EM, Johnson T, Thorleifsson G, Luan J, Donnelly LA, Kanoni S, Petersen AK, Pihur V, Strawbridge RJ, Shungin D, Hughes MF, Meirelles O, Kaakinen M, Bouatia-Naji N, Kristiansson K, Shah S et al.. 2016. Nature genetics. 48: 1171-1184 A1 Journal article (refereed), original research -
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK, Grarup N, Sim X, Barnes DR, Witkowska K, Staley JR, Tragante V, Tukiainen T, Yaghootkar H, Masca N, Freitag DF, Ferreira T, Giannakopoulou O, Tinker A, Harakalova M et al. 2016. Nature genetics. 48: 1151-1161 A1 Journal article (refereed), original research -
Associations of multiple lipoprotein and apolipoprotein measures with worsening of glycemia and incident type 2 diabetes in 6607 non-diabetic Finnish men
Fizelova Maria, Miilunpohja Manna, Kangas Antti J, Soininen Pasi, Kuusisto Johanna, Ala-Korpela Mika, Laakso Markku, Stancáková Alena. 2015. Atherosclerosis. 240: 272-277 A1 Journal article (refereed), original research -
Biological interpretation of genome-wide association studies using predicted gene functions
Pers Tune H, Karjalainen Juha M, Chan Yingleong, Westra Harm-Jan, Wood Andrew R, Yang Jian, Lui Julian C, Vedantam Sailaja, Gustafsson Stefan, Esko Tonu, Frayling Tim, Speliotes Elizabeth K, Genetic Investigation of ANthropometric Traits (GIANT) Consortium (incl. Johanna Kuusisto, Markku Laakso, Timo Lakka, Matti Uusitupa), Boehnke Michael, Raychaudhuri Soumya, Fehrmann Rudolf SN, Hirschhorn Joel N, Franke Lude. 2015. Nature communications. 6: 5890 A1 Journal article (refereed), original research -
Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 finnish men
Vangipurapu Jagadish, Stancáková Alena, Kuulasmaa Teemu, Kuusisto Johanna, Laakso Markku. 2015. PLoS ONE. 10: e0124028 A1 Journal article (refereed), original research -
Dietary polyunsaturated fatty acids and the Pro12Ala polymorphisms of PPARG regulate serum lipids through divergent pathways: a randomized crossover clinical trial
Pihlajamäki Jussi, Schwab Ursula, Kaminska Dorota, Ågren Jyrki, Kuusisto Johanna, Kolehmainen Marjukka, Paananen Jussi, Laakso Markku, Uusitupa Matti. 2015. Genes and nutrition. 10: 43 A1 Journal article (refereed), original research -
Directional dominance on stature and cognition in diverse human populations
Joshi Peter K, Esko Tonu, Mattsson Hannele, Eklund Niina, Gandin Ilaria, Nutile Teresa, Jackson Anne U, Schurmann Claudia, Smith Albert V, Zhang Weihua, Okada Yukinori, Stancáková Alena, Faul Jessica D, Zhao Wei, Bartz Traci M, Pina Concas Maria, Franceschini Nora, Enroth Stefan, Vitart Veronique, Trompet Stella et al (incl. Kuusisto Johanna, Laakso Markku). 2015. Nature. 523: 459-462 A1 Journal article (refereed), original research -
Evaluation of the efficacy and safety of three dosing regimens of agalsidase alfa enzyme replacement therapy in adults with Fabry disease
Golán L, Goker-Alpan O, Holida M, Kantola I, Klopotowski M, Kuusisto J, Linhart A, Musial J, Nicholls K, Gonzalez-Rodriguez D, Sharma R, Vujkovac B, Chang P, Wijatyk A. 2015. Drug design development and therapy. 2015: 3435-3444 A1 Journal article (refereed), original research -
Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men
Takkunen Markus J, de Mello Vanessa D, Schwab Ursula S, Kuusisto Johanna, Vaittinen Maija, Ågren Jyrki J, Laakso Markku, Pihlajamäki Jussi, Uusitupa MI. 2015. Molecular nutrition and food research. 2016; 60: 381-389 A1 Journal article (refereed), original research -
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, William Rayner N, Robertson N, Scott RA, Prokopenko I, Scott LJ, Green T, Sparso T, Thuillier D, Yengo L, Grallert H, Wahl S, Frånberg M et al.. 2015. Nature genetics. 47: 1415-1425 A1 Journal article (refereed), original research -
Genetic studies of body mass index yield new insights for obesity biology
Locke Adam E, Kahali Bratati, Berndt Sonja I, Justice Anne E, Pers Tune H, Day Felix R, Powell Corey, Vedantam Sailaja, Buchkovich Martin L, Yang Jian, Croteau-Chonka Damien C, Esko Tonu, Fall Tove, Ferreira Teresa, Gustafsson Stefan, Kutalik Zoltán, Luan Jian'an, Mägi Reedik, Randall Joshua C, Winkler Thomas W et al. 2015. Nature. 518: 197-206 A1 Journal article (refereed), original research -
Genetically determined height and coronary artery disease
Christopher P. Nelson, Stephen E. Hamby, Danish Saleheen, Jenna C. Hopewell, Lingyao Zeng, Themistocles L. Assimes, Stavroula Kanoni, Christina Willenborg, Stephen Burgess, Phillipe Amouyel, Sonia Anand, Stefan Blankenberg, Bernhard O. Boehm, Robert J. Clarke, Rory Collins, George Dedoussis, Martin Farrall, Paul W. Franks, Leif Groop, Alistair S. Hall et al. for the CARDIoGRAM+C4D Consortium (inicl. Kuusisto, Laakso). 2015. The new england journal of medicine. 372: 1608-1618 A1 Journal article (refereed), original research -
Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB
Berglund Lisa M, Lyssenko Valeriya, Ladenvall Claes, Kotova Olga, Edsfeldt Andreas, Pilgaard Kasper, Alkayyali Sami, Brøns Charlotte, Forsblom Carol, Jonsson Anna, Zetterqvist Anna V, Nitulescu Mihaela, McDavitt Christian Ruiz, Dunér Pontus, Stancáková Alena, Kuusisto Johanna, Ahlqvist Emma, Lajer Maria, Tarnow Lise, Madsbad Sten et al. 2015. Diabetes. (2016) 65: 239-254 A1 Journal article (refereed), original research -
Glycated hemoglobin levels are mostly dependent on nonglycemic parameters in 9398 Finnish men without diabetes
Fizelova Maria, Stancáková Alena, Lorenzo Carlos, Haffner Steven M, Cederberg Henna, Kuusisto Johanna, Laakso Markku. 2015. Journal of clinical endocrinology and metabolism. 100: 1989-1996 A1 Journal article (refereed), original research -
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus
Mahajan Anubha, Sim Xueling, Ng Hui Jin, Manning Alisa, Rivas Manuel A, Highland Heather M, Locke Adam E, Grarup Niels, Im Hae Kyung, Cingolani Pablo, Flannick Jason, Fontanillas Pierre, Fuchsberger Christian, Gaulton Kyle J, Teslovich Tanya M, Rayner N William, Robertson Neil R, Beer Nicola L, Rundle Jana K, Bork-Jensen Jette et al. On Behalf of the T2D-GENES consortium and GoT2D consortium. 2015. PLoS genetics. 11: e1004876 A1 Journal article (refereed), original research -
Increased Visceral Adipose Tissue as a Potential Risk Factor in Patients with Embolic Stroke of Undetermined Source (ESUS)
Muuronen Antti T, Taina Mikko, Hedman Marja, Marttila Jarkko, Kuusisto Johanna, Onatsu Juha, Vanninen Ritva, Jäkälä Pekka, Sipola Petri, Mustonen Pirjo. 2015. PLoS ONE. 10: e0120598 A1 Journal article (refereed), original research -
Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort
Cederberg Henna, Stancáková Alena, Yaluri Nagendra, Modi Shalem, Kuusisto Johanna, Laakso Markku. 2015. Diabetologia. 58: 1109-1117 A1 Journal article (refereed), original research -
Increased ventilatory response to exercise in symptomatic and asymptomatic LMNA mutation carriers: a follow-up study
Ollila L, Heliö T, Sovijärvi A, Jalanko M, Kaartinen M, Kuusisto J, Kärkkäinen S, Jurkko R, Reissell E, Palojoki E, Piirilä P. 2015. Clinical physiology and functional imaging. 2017; 37: 8-16 A1 Journal article (refereed), original research -
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
Wessel Jennifer, Chu Audrey Y, Willems Sara M, Wang Shuai, Yaghootkar Hanieh, Brody Jennifer A, Dauriz Marco, Hivert Marie-France, Raghavan Sridharan, Lipovich Leonard, Hidalgo Bertha, Fox Keolu, Huffman Jennifer E, An Ping, Lu Yingchang, Rasmussen-Torvik Laura J, Grarup Niels, Ehm Margaret G, Li Li, Baldridge Abigail S et al. 2015. Nature communications. 6: 5897 A1 Journal article (refereed), original research -
Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol
Roman Tamara S, Marvelle Amanda F, Fogarty Marie P, Vadlamudi Swarooparani, Gonzalez Arlene J, Buchkovich Martin L, Huyghe Jeroen R, Fuchsberger Christian, Jackson Anne U, Wu Ying, Civelek Mete, Lusis Aldons J, Gaulton Kyle J, Sethupathy Praveen, Kangas Antti J, Soininen Pasi, Ala-Korpela Mika, Kuusisto Johanna, Collins Francis S, Laakso Markku, Boehnke Michael, Mohlke Karen L.. 2015. American journal of human genetics. 97: 801-815 A1 Journal article (refereed), original research -
New genetic loci link adipose and insulin biology to body fat distribution
Shungin Dmitry, Winkler Thomas W, Croteau-Chonka Damien C, Ferreira Teresa, Locke Adam E, Mägi Reedik, Strawbridge Rona J, Pers Tune H, Fischer Krista, Justice Anne E, Workalemahu Tsegaselassie, Wu Joseph MW, Buchkovich Martin L, Heard-Costa Nancy L, Roman Tamara S, Drong Alexander W, Song Ci, Gustafsson Stefan, Day Felix R, Esko Tonu et al. 2015. Nature. 518: 187-196 A1 Journal article (refereed), original research -
Plasma fatty acids as predictors of glycaemia and type 2 diabetes
Lankinen Maria A, Stancáková Alena, Uusitupa Matti, Ågren Jyrki, Pihlajamäki Jussi, Kuusisto Johanna, Schwab Ursula, Laakso Markku. 2015. Diabetologia. 58: 2533-2544 A1 Journal article (refereed), original research -
Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells
Yaluri Nagendra, Modi Shalem, López Rodríguez Maykel, Stancáková Alena, Kuusisto Johanna, Kokkola Tarja, Laakso Markku. 2015. PLoS ONE. 10: e0142902 A1 Journal article (refereed), original research -
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Winkler Thomas W, Justice Anne E, Graff Mariaelisa, Barata Llilda, Feitosa Mary F, Chu Su, Czajkowski Jacek, Esko Tõnu, Fall Tove, Kilpeläinen Tuomas O, Lu Yingchang, Mägi Reedik, Mihailov Evelin, Pers Tune H, Rüeger Sina, Teumer Alexander, Ehret Georg B, Ferreira Teresa, Heard-Costa Nancy L, Karjalainen Juha et al. 2015. PLoS genetics. 11: e1005378 A1 Journal article (refereed), original research -
The Metabolome in Finnish Carriers of the MYBPC3-Q1061X Mutation for Hypertrophic Cardiomyopathy
Jorgenrud Benedicte, Jalanko Mikko, Heliö Tiina, Jääskeläinen Pertti, Laine Mika, Hilvo Mika, Nieminen Markku S., Laakso Markku, Hyötyläinen Tuulia, Oresic Matej, Kuusisto Johanna. 2015. PLoS ONE. 10: e0134184 A1 Journal article (refereed), original research -
A Central Role for GRB10 in Regulation of Islet Function in Man
Prokopenko Inga, Poon Wenny, Mägi Reedik, Prasad BR, Salehi S Albert, Almgren Peter, Osmark Peter, Bouatia-Naji Nabila, Wierup Nils, Fall Tove, Stancáková Alena, Barker Adam, Lagou Vasiliki, Osmond Clive, Xie Weijia, Lahti Jari, Jackson Anne U, Cheng Yu-Ching, Liu Jie, O'Connell Jeffrey R et al. (including Kuusisto Johanna, Laakso Markku, Lakka Timo). 2014. PLoS genetics. 10: e1004235 A1 Journal article (refereed), original research -
A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell
Kulzer JR, Stitzel ML, Morken MA, Huyghe JR, Fuchsberger C, Kuusisto J, Laakso M, Boehnke M, Collins FS, Mohlke KL. 2014. American journal of human genetics. 94: 186-197 A1 Journal article (refereed), original research -
A new common mutation in the cardiac beta-myosin heavy chain gene in Finnish patients with hypertrophic cardiomyopathy
Jääskeläinen Pertti, Heliö Tiina, Aalto-Setälä Katriina, Kaartinen Maija, Ilveskoski Erkki, Hämäläinen Liisa, Melin John, Kärkkäinen Satu, Peuhkurinen Keijo, Nieminen Markku S, Laakso Markku, the FinHCM MStudy Group, Kuusisto Johanna. 2014. Annals of medicine. 46: 424-429 A1 Journal article (refereed), original research -
Associations of erythrocyte membrane fatty acids with the concentrations of C-reactive protein, interleukin 1 receptor antagonist and adiponectin in1373 men
Takkunen MJ, de Mello VDF, Schwab US, Ågren JJ, Kuusisto J, Uusitupa MIJ. 2014. Prostaglandins leukotrienes and essential fatty acids. 91: 169-174 A1 Journal article (refereed), original research -
Defining the role of common variation in the genomic and biological architecture of adult human height
Wood Andrew R, Esko Tonu, Yang Jian, Vedantam Sailaja, Pers Tune H, Gustafsson Stefan, Chu Audrey Y, Estrada Karol, Luan Jian'an, Kutalik Zoltán, Amin Najaf, Buchkovich Martin L, Croteau-Chonka Damien C, Day Felix R, Duan Yanan, Fall Tove, Fehrmann Rudolf, Ferreira Teresa, Jackson Anne U, Karjalainen Juha et.al.. 2014. Nature genetics. 46: 1173-86 A1 Journal article (refereed), original research -
Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations
Ganesh SK, Chasman D, Larson MG, Guo X, Verwoert G, Bis JC, Gu X, Smith AV, Yang ML, Zhang Y, Ehret G, Rose LM, Hwang SJ, Papanicolau GJ, Sijbrands EJ, Rice K, Eiriksdottir G, Pihur V, Ridker PM, Vasan RS (including Kuusisto J, Laakso M). 2014. American journal of human genetics. 95: 49-65 A1 Journal article (refereed), original research -
Family history of type 2 diabetes increases the risk of both obesity and its complications: is type 2 diabetes a disease of inappropriate lipid storage?
Cederberg Henna, Stancakova Alena, Kuusisto Johanna, Laakso Markku, Smith Ulf. 2014. Journal of internal medicine. 277: 540-551 A1 Journal article (refereed), original research -
Fasting and OGTT-derived measures of insulin resistance as compared with the euglycemic-hyperinsulinemic clamp in non-diabetic Finnish offspring of type 2 diabetic individuals
Lorenzo Carlos, Haffner Steven M, Stancáková Alena, Kuusisto Johanna, Laakso Markku. 2014. Journal of clinical endocrinology and metabolism. 2015; 100: 544-550 A1 Journal article (refereed), original research -
Genome-wide Enrichment Analysis between Endometriosis and Obesity-related Traits Reveals Novel Susceptibility Loci
Rahmioglu Nilufer, Macgregor Stuart, Drong Alexander W, Hedman Åsa K, Harris Holly R, Randall Joshua C, Prokopenko Inga, The International EndoGene Consortium (IEC), The GIANT Consortium, Nyholt Dale R, Morris Andrew P, Montgomery Grant W, Missmer Stacey A, Lindgren Cecilia M, Zondervan Krina T. 2014. Human molecular genetics. Epub ahead of print: - A1 Journal article (refereed), original research -
Genome-wide association study identifies three novel loci for type 2 diabetes
Hara Kazuo, Fujita Hayato, Johnson Todd A, Yamauchi Toshimasa, Yasuda Kazuki, Horikoshi Momoko, Peng Chen, Hu Cheng, Ma Ronald CW, Imamura Minako, Iwata Minoru, Tsunoda Tatsuhiko, Morizono Takashi, Shojima Nobuhiro, So Wing Yee, Leung Ting Fan, Kwan Patrick, Zhang Rong, Wang Jie, Yu Weihui et al. (including Kuusisto Johanna, Laakso Markku). 2014. Human molecular genetics. 23: 239-246 A1 Journal article (refereed), original research -
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium, Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, Ng MC, Prokopenko I, Saleheen D, Wang X, Zeggini E, Abec. 2014. Nature genetics. 46: 234-244 A1 Journal article (refereed), original research -
Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity
Dimas Antigone S, Lagou Vasiliki, Barker Adam, Knowles Joshua W, Mägi Reedik, Hivert Marie-France, Benazzo Andrea, Rybin Denis, Jackson Anne U, Stringham Heather M, Song Ci, Fischer-Rosinsky Antje, Boesgaard Trine Wellöw, Grarup Niels, Abbasi Fahim A, Assimes Themistocles L, Hao Ke, Yang Xia, Lecoeur Cécile, Barroso Inês et al (including Kuusisto Johanna, Laakso Markku). 2014. Diabetes. 63: 2158-2171 A1 Journal article (refereed), original research -
Insulin resistance and hyperglycaemia in cardiovascular disease development
Laakso Markku, Kuusisto Johanna. 2014. Nature reviews endocrinology. 10: 293-302 A2 Review article, Literature review, Systematic review -
Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans
Männistö Ville T, Simonen Marko, Hyysalo Jenni, Soininen Pasi, Kangas Antti J, Kaminska Dorota, Matte Ananda K, Venesmaa Sari, Käkelä Pirjo, Kärjä Vesa, Arola Johanna, Gylling Helena, Cederberg Henna, Kuusisto Johanna, Laakso Markku, Yki-Järvinen Hannele, Ala-Korpela Mika, Pihlajamäki Jussi. 2014. Liver international. 2015; 35: 1853-1861 A1 Journal article (refereed), original research -
Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms
Claussnitzer Melina, Dankel Simon N, Klocke Bernward, Grallert Harald, Glunk Viktoria, Berulava Tea, Lee Heekyoung, Oskolkov Nikolay, Fadista Joao, Ehlers Kerstin, Wahl Simone, Hoffmann Christoph, Qian Kun, Rönn Tina, Riess Helene, Müller-Nurasyid Martina, Bretschneider Nancy, Schroeder Timm, Skurk Thomas, Horsthemke Bernhard et al. (including Kuusisto Johanna, Laakso Markku). 2014. Cell. 156: 343-358 A1 Journal article (refereed), original research -
Markers of tissue-specific insulin resistance predict the worsening of hyperglycemia, incident type 2 diabetes and cardiovascular disease
Fízelóvá Maria, Cederberg Henna, Stancakova Alena, Jauhiainen Raimo, Vangipurapu Jagadish, Kuusisto Johanna, Laakso Markku. 2014. PLoS ONE. 9: e109772 A1 Journal article (refereed), original research -
Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes
Ng MC, Shriner D, Chen BH, Li J, Chen WM, Guo X, Liu J, Bielinski SJ, Yanek LR, Nalls MA, Comeau ME, Rasmussen-Torvik LJ, Jensen RA, Evans DS, Sun YV, An P, Patel SR, Lu Y, Long J, Armstrong LL et al. (including Kuusisto J, Laakso M). 2014. PLoS genetics. 10: e1004517 A1 Journal article (refereed), original research -
Multi-ethnic fine-mapping of 14 central adiposity loci
Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR, Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu J, Li G, Ruiz-Narvaez EA, Chen WM et al. (including Kuusisto J, Laakso M). 2014. Human molecular genetics. 23: 4738-4744 A1 Journal article (refereed), original research -
Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index
Hoggart Clive J, Venturini Giulia, Mangino Massimo, Gomez Felicia, Ascari Giulia, Zhao Jing Hua, Teumer Alexander, Winkler Thomas W, T¨ernikova Natalia, Luan Jian'an, Mihailov Evelin, Ehret Georg B, Zhang Weihua, Lamparter David, Esko Tõnu, Macé Aurelian, Rüeger Sina, Bochud Pierre-Yves, Barcella Matteo, Dauvilliers Yves et al (including Atalay Mustafa, Kuusisto Johanna, Lakka Timo, Yaluri Alena, Laakso Markku, Uusitupa Matti). 2014. PLoS genetics. 10: e1004508 A1 Journal article (refereed), original research -
Quality control and conduct of genome-wide association meta-analyses
Winkler Thomas W, Day Felix R, Croteau-Chonka Damien C, Wood Andrew R, Locke Adam E, Mägi Reedik, Ferreira Teresa, Fall Tove, Graff Mariaelisa, Justice Anne E, Luan Jian'an, Gustafsson Stefan, Randall Joshua C, Vedantam Sailaja, Workalemahu Tsegaselassie, Kilpeläinen Tuomas O, Scherag André, Esko Tonu, Kutalik Zoltán, Heid Iris M, The Genetic Investigation of Anthropometric Traits (GIANT) Consortium et al. (including Atalay Mustafa, Kuusisto Johanna, Laakso Markku, Yaluri Alena). 2014. Nature physics. 9: 1192-1212 A1 Journal article (refereed), original research -
Sepelvaltimoiden pallolaajennushoidon tulokset ja vaikutus potilaiden vointiin ja oireisiin
Kemiläinen H, Kaulamo J, Heikkinen O, Miettinen H, Kuusisto J. 2014. Duodecim. 130: 63-70 A1 Journal article (refereed), original research -
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
Li H, Gan W, Lu L, Dong X, Han X, Hu C, Yang Z, Sun L, Bao W, Li P, He M, Sun L, Wang Y, Zhu J, Ning Q, Tang Y, Zhang R, Wen J, Wang D, Zhu X, et al. (including Kuusisto J, Laakso M). 2013. Diabetes. 62: 291-298 A1 Journal article (refereed), original research -
Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss
Kaminska D, Hämäläinen M, Cederberg H, Käkelä P, Venesmaa S, Miettinen P, Ilves I, Herzig KH, Kolehmainen M, Karhunen L, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. 2013. Diabetologia. Epub 2013 Nov 7.: 1-5 A1 Journal article (refereed), original research -
Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes
Mahendran Y, Ågren J, Uusitupa M, Cederberg H, Vangipurapu J, Stancakova A, Schwab U, Kuusisto J, Laakso M. 2013. American journal of clinical nutrition. -: - A1 Journal article (refereed), original research -
Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men
Mahendran Y, Vangipurapu J, Cederberg H, Stancáková A, Pihlajamäki J, Soininen P, Kangas AJ, Paananen J, Civelek M, Saleem NK, Pajukanta P, Lusis AJ, Bonnycastle LL, Morken MA, Collins FS, Mohlke KL, Boehnke M, Ala-Korpela M, Kuusisto J, Laakso M. 2013. Diabetes. 62: 3618-3626 A1 Journal article (refereed), original research -
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts
Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, Wood AR, Michaëlsson K, Vandenput L, Zgaga L, Yerges-Armstrong LM, McCarthy MI, Dupuis J, Kaakinen M, Kleber ME, Jameson K, et al. (including Laakso M, Kuusisto J). 2013. PLoS medicine. 10: e1001383 A1 Journal article (refereed), original research -
Common variants associated with plasma triglycerides and risk for coronary artery disease
Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang H-Y, Demirkan A, Den Hertog HM, Donnelly LA, Ehret GB, Esko T et.al.. 2013. Nature genetics. 45: 1345-52 A1 Journal article (refereed), original research -
Desmosterol in human nonalcoholic steatohepatitis
Simonen M, Männistö V, Leppänen J, Kaminska D, Kärjä V, Venesmaa S, Käkelä P, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. 2013. Hepatology. 58: 976-982 A1 Journal article (refereed), original research -
Dietary fat in relation to erythrocyte fatty acid composition in men
Takkunen M, Ågren J, Kuusisto J, Laakso M, Uusitupa M, Schwab U. 2013. Lipids. 48: 1093-1102 A1 Journal article (refereed), original research -
Discovery and refinement of loci associated with lipid levels
Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang H-Y, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF et.al.. 2013. Nature genetics. 45: 1274-1283 A1 Journal article (refereed), original research -
Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion
Huyghe JR, Jackson AU, Fogarty MP, Buchkovich ML, Stancáková A, Stringham HM, Sim X, Yang L, Fuchsberger C, Cederberg H, Chines PS, Teslovich TM, Romm JM, Ling H, McMullen I, Ingersoll R, Pugh EW, Doheny KF, Neale BM, Daly MJ, et al (including J Kuusisto, M Laakso). 2013. Nature genetics. 45: 197-201 A2 Review article, Literature review, Systematic review -
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
Albrechtsen A, Grarup N, Li Y, Sparsø T, Tian G, Cao H, Jiang T, Kim SY, Korneliussen T, Li Q, Nie C, Wu R, Skotte L, Morris AP, Ladenvall C, Cauchi S, Stančáková A, Andersen G, Astrup A, Banasik K, et al. (including Stancakova A, Kuusisto J, Laakso M). 2013. Diabetologia. 56: 298-310 A1 Journal article (refereed), original research -
Genetic Loci for Retinal Arteriolar Microcirculation
Sim X, Jensen RA, Ikram MK, Cotch MF, Li X, MacGregor S, Xie J, Smith AV, Boerwinkle E, Mitchell P, Klein R, Klein BE, Glazer NL, Lumley T, McKnight B, Psaty BM, de Jong PT, Hofman A, Rivadeneira F, Uitterlinden AG et al (including M Laakso, J Kuusisto). 2013. PLoS ONE. 8: e65804 A1 Journal article (refereed), original research -
Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits
Civelek M, Hagopian R, Pan C, Che N, Yang WP, Kayne PS, Saleem NK, Cederberg H, Kuusisto J, Gargalovic PS, Kirchgessner TG, Laakso M, Lusis AJ.. 2013. Human molecular genetics. 22: 3023-3037 A1 Journal article (refereed), original research -
Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21
Tabassum R, Chauhan G, Dwivedi OP, Mahajan A, Jaiswal A, Kaur I, Bandesh K, Singh T, Mathai BJ, Pandey Y, Chidambaram M, Sharma A, Chavali S, Sengupta S, Ramakrishnan L, Venkatesh P, Aggarwal SK, Ghosh S, Prabhakaran D, Srinath RK, et al (including M Laakso, J Kuusisto). 2013. Diabetes. 62: 977-986 A1 Journal article (refereed), original research -
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
Saxena R, Saleheen D, Been LF, Garavito ML, Braun T, Bjonnes A, Young R, Ho WK, Rasheed A, Frossard P, Sim X, Hassanali N, Radha V, Chidambaram M, Liju S, Rees SD, Ng DP, Wong TY, Yamauchi T, Hara K, et al. (including J Kuusisto, M Laakso). 2013. Diabetes. 62: 1746-1755 A1 Journal article (refereed), original research -
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, Luan J, Randall JC, Vedantam S, Willer CJ, Winkler TW, et al. (including Atalay M, Kuusisto J, Lakka TA, Stancakova A, Laakso M, Uusitupa M). 2013. Nature genetics. 45: 501-512 A1 Journal article (refereed), original research -
Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men
Mahendran Yuvaraj, Cederberg Henna, Vangipurapu Jagadish, Kangas Antti J, Soininen Pasi, Kuusisto Johanna, Uusitupa Matti, Ala-Korpela Mika, Laakso Markku. 2013. Diabetes care. 36: 3732-3738 A1 Journal article (refereed), original research -
Idiopathic dilated cardiomyopathy and chronic atrial fibrillation
Tuomainen PO, Magga J, Fedacko J, Kärkkäinen S, Miettinen K, Vanninen E, Kuusisto J, Peuhkurinen KJ. 2013. Clinical physiology and functional imaging. e-pub: e-pub A1 Journal article (refereed), original research -
Link between GIP and osteopontin in adipose tissue and insulin resistance
Ahlqvist E, Osmark P, Kuulasmaa T, Pilgaard K, Omar B, Brøns C, Kotova O, Zetterqvist AV, Stancáková A, Jonsson A, Hansson O, Kuusisto J, Kieffer TJ, Tuomi T, Isomaa B, Madsbad S, Gomez MF, Poulsen P, Laakso M, Degerman E, et al. (including Pihlajamäki J). 2013. Diabetes. 62: 2088-2094 A1 Journal article (refereed), original research -
Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.
Yaghootkar H, Lamina C, Scott RA, Dastani Z, Hivert M-F, Warren LL, Stancáková A, Buxbaum SG, Lyytikäinen L-P, Henneman P, Wu Y, Cheung CYY, Pankow JS, Jackson AU, Gustafsson S, Zhao JH, Ballantyne CM, Xie W, Bergman RN, Boehnke M et al. (including J Kuusisto, M Laakso, J Paananen). 2013. Diabetes. 62: 3589-3598 A1 Journal article (refereed), original research -
Meta-analysis of gene-level associations for rare variants based on single-variant statistics
Hu Y-J, Berndt SI, Gustafsson S, Ganna A, Genetic Investigation of ANthropometric Traits (GIANT) Consortium (including M Atalay, T Lakka, J Kuusisto, M Laakso), Hirschhorn J, North KE, Ingelsson E, Lin D-Y et.al.. 2013. American journal of human genetics. 93: 236-248 A1 Journal article (refereed), original research -
Mining the human phenome using allelic scores that index biological intermediates
Evans DM, Brion MJ, Paternoster L, Kemp JP, McMahon G, Munafò M, Whitfield JB, Medland SE, Montgomery GW; GIANT Consortium; CRP Consortium; TAG Consortium, Timpson NJ, St Pourcain B, Lawlor DA, Martin NG, Dehghan A, Hirschhorn J, Davey Smith G et al. (including M Laakso ja J Kuusisto). 2013. PLoS genetics. 9: e1003919 A1 Journal article (refereed), original research -
Non-cholesterol sterol levels predict hyperglycemia and conversion to type 2 diabetes in finnish men
Cederberg H, Gylling H, Miettinen TA, Paananen J, Vangipurapu J, Pihlajamäki J, Kuulasmaa T, Stancáková A, Smith U, Kuusisto J, Laakso M. 2013. PLoS ONE. 8: e67406 A1 Journal article (refereed), original research -
Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, Workalemahu T, Feitosa MF, Croteau-Chonka DC, Day FR, Fall T, Ferreira T, Gustafsson S, Locke AE, Mathieson I, Scherag A, et al. (including J Kuusisto, M Laakso, M Atalay, T Lakka). 2013. PLoS genetics. 9: e1003500 A1 Journal article (refereed), original research -
The SH2B1 obesity locus and abnormal glucose homeostasis: lack of evidence for association from a meta-analysis in individuals of European ancestry
Prudente S, Copetti M, Morini E, Mendonca C, Andreozzi F, Chandalia M, Baratta R; DIAGRAM consortium (including Kuusisto J, Laakso M), Pellegrini F, Mercuri L, Bailetti D, Abate N, Frittitta L, Sesti G, Florez JC, Doria A, Trischitta V. 2013. Nutrition metabolism and cardiovascular diseases. 23: 1043-1049 A1 Journal article (refereed), original research -
Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained
Wu Y, Waite LL, Jackson AU, Sheu WH, Buyske S, Absher D, Arnett DK, Boerwinkle E, Bonnycastle LL, Carty CL, Cheng I, Cochran B, Croteau-Chonka DC, Dumitrescu L, Eaton CB, Franceschini N, Guo X, Henderson BE, Hindorff LA, Kim E, et al. (including Stancakova A, Kuusisto J, Laakso M, Uusitupa M, Rauramaa R Lakka T.). 2013. PLoS genetics. 9: e1003379 A1 Journal article (refereed), original research -
Two founder mutations in the alpha-tropomyosin and the cardiac myosin-binding protein C genes are common causes of hypertrophic cardiomyopathy in the Finnish population
Jääskeläinen P, Heliö T, Aalto-Setälä K, Kaartinen M, Ilveskoski E, Hämäläinen L, Melin J, Nieminen MS, Laakso M, Kuusisto J; FinHCM study group, Kervinen H, Mustonen J, Juvonen J, Niemi M, Uusimaa P, Huttunen M, Kotila M, Pietilä M.. 2013. Annals of medicine. 45: 85-90 A1 Journal article (refereed), original research -
Update on type 2 diabetes as a cardiovascular disease risk equivalent
Kuusisto J, Laakso M. 2013. Current cardiology reports. 15: 331 A1 Journal article (refereed), original research -
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Manning AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, Rybin D, Liu CT, Bielak LF, Prokopenko I, Amin N, Barnes D, Cadby G, Hottenga JJ, Ingelsson E, Jackson AU, Johnson T, Kanoni S, Ladenvall C, Lagou V et.al.. 2012. Nature genetics. 44: 659-669 A1 Journal article (refereed), original research -
A genome-wide association search for type 2 diabetes genes in African Americans
Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN, Bostrom MA, Rudock ME, Talbert ME, Lewis JP; DIAGRAM Consortium; MAGIC Investigators, Ferrara A, Lu L, Ziegler JT, Sale MM, Divers J, Shriner D et.al.. 2012. PLoS ONE. 7: e29202 A1 Journal article (refereed), original research -
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.
Imamura M, Maeda S, Yamauchi T, Hara K, Yasuda K, Morizono T, Takahashi A, Horikoshi M, Nakamura M, Fujita H, Tsunoda T, Kubo M, Watada H, Maegawa H, Okada-Iwabu M, Iwabu M, Shojima N, Ohshige T, Omori S, Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium (including M Laakso, J Kuusisto). 2012. Human molecular genetics. 21: 3042-3049 A1 Journal article (refereed), original research -
Adipose Co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes
Haas BE, Horvath S, Pietiläinen KH, Cantor RM, Nikkola E, Weissglas-Volkov D, Rissanen A, Civelek M, Cruz-Bautista I, Riba L, Kuusisto J, Kaprio J, Tusie-Luna T, Laakso , Aguilar-Salinas CA, Pajukanta P. 2012. Bmc medical genomics. 5: 61 A1 Journal article (refereed), original research -
Association between liver insulin resistance and cardiovascular risk factors
Vangipurapu Jagadish, Stančáková A, Kuulasmaa Teemu, Soininen Pasi, Kangas AJ, Ala-Korpela Mika, Kuusisto Johanna, Laakso Markku. 2012. Journal of internal medicine. 272: 402-408 A1 Journal article (refereed), original research -
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
Stahl EA, Wegmann D, Trynka G, Gutierrez-Achury J, Do R, Voight BF, Kraft P, Chen R, Kallberg HJ, Kurreeman FA; Diabetes Genetics Replication and Meta-analysis Consortium; Myocardial Infarction Genetics Consortium, Kathiresan S, Wijmenga C, Gregersen PK, Alfredsson L, Siminovitch KA, Worthington J, de Bakker PI, Raychaudhuri S, Plenge RM. 2012. Nature genetics. 44: 483-489 A1 Journal article (refereed), original research -
Circadian gene variants and susceptibility to type 2 diabetes: a pilot study
Kelly MA, Rees SD, Hydrie MZI, Shera AS, Bellary S, O¿Hare JP, Kumar S, Taheri S, Basit A, Barnett AH, DIAGRAM consortium, SAT2D consortium. 2012. PLoS ONE. 7: e32670 A1 Journal article (refereed), original research -
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women
Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K; GIANT Consortium; MAGIC Consortium; GLGC Consortium, Johnson AD, Foster MC, Greenawalt DM, Griffin P, Ding J, Newman AB, Tylavsky F, Miljkovic I, Kritchevsky SB, Launer L et.al.. 2012. PLoS genetics. 8: e1002695 A1 Journal article (refereed), original research -
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations
Demirkan A, van Duijn CM, Ugocsai P, Isaacs A, Pramstaller PP, Liebisch G, Wilson JF, Johansson Å, Rudan I, Aulchenko YS, Kirichenko AV, Janssens AC, Jansen RC, Gnewuch C, Domingues FS, Pattaro C, Wild SH, Jonasson I, Polasek O, Zorkoltseva IV et.al.. 2012. PLoS genetics. 8: e1002490 A1 Journal article (refereed), original research -
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits
Kristiansson Kati, Perola Markus, Tikkanen Emmi, Kettunen Johannes, Surakka Ida, Havulinna Aki S, Stancáková Alena, Barnes Chris, Widen Elisabeth, Kajantie Eero, Eriksson Johan G, Viikari Jorma, Kähönen Mika, Lehtimäki Terho, Raitakari Olli T, Hartikainen Anna-Liisa, Ruokonen Aimo, Pouta Anneli, Jula Antti, Kangas Antti J et al. 2012. Circulation: cardiovascular genetics. 5: 242-249 A1 Journal article (refereed), original research -
Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men
Stancáková Alena, Civelek Mete, Saleem Niyas K, Soininen Pasi, Kangas Antti J, Cederberg Henna, Paananen Jussi, Pihlajamäki Jussi, Bonnycastle Lori L, Morken Mario A, Boehnke Michael, Pajukanta Päivi, Lusis Aldons J, Collins Francis S, Kuusisto Johanna, Ala-Korpela Mika, Laakso Markku. 2012. Diabetes. 61: 1895-1902 A1 Journal article (refereed), original research -
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies
Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN, Gao P, Saleheen D, Rendon A, Nelson CP, Braund PS, Hall AS, Chasman DI, Tybjaerg-Hansen A, Chambers JC, Benjamin EJ, Franks PW, Clarke R, Wilde AAM, Trip MD et.al.. 2012. The Lancet. 379: 1205-1213 A1 Journal article (refereed), original research -
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik L, Yengo L, Lecoeur C, Shungin D, Sanna S, Sidore C, Johnson PCD, Jukema JW, Johnson T et.al.. 2012. Nature genetics. 44: 991-1005 A1 Journal article (refereed), original research -
Large-scale association analysis identifies new risk loci for coronary artery disease
The CARDIoGRAMplusC4D Consortium (including M Laakso, J Kuusisto), Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, Stirrups K, König IR, Cazier JB, Johansson A, Hall AS, Lee JY, Willer CJ, Chambers JC, Esko T et al. 2012. Nature genetics. 45: 25-33 A1 Journal article (refereed), original research -
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, Prokopenko I, Kang HM, Dina C, Esko T, Fraser RM, Kanoni S, Kumar A, Lagou V, Langenberg C, Luan J et.al.. 2012. Nature genetics. 44: 981-990 A1 Journal article (refereed), original research -
Lipoprotein subclass profiles in individuals with varying degrees of glucose tolerance: a population-based study of 9399 Finnish men
Wang J, Stančáková A, Soininen P, Kangas AJ, Paananen J, Kuusisto J, Ala-Korpela M, Laakso M. 2012. Journal of internal medicine. 272: 562-572 A1 Journal article (refereed), original research -
Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk
Marquez M, Huyvaert M, Perry JR, Pearson RD, Falchi M, Morris AP, Vivequin S, Lobbens S, Yengo L, Gaget S, Pattou F, Poulain-Godefroy O, Charpentier G, Carlsson LM, Jacobson P, Sjöström L, Lantieri O, Heude B, Walley A, Balkau B, Marre M, Froguel P, Cauchi S; DIAGRAM Consortium. 2012. Diabetes. 61: 524-530 A1 Journal article (refereed), original research -
Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy
Kuusisto J, Kärjä V, Sipola P, Kholová I, Peuhkurinen K, Jääskeläinen P, Naukkarinen A, Ylä-Herttuala S, Punnonen K, Laakso M. 2012. Heart. 98: 1007-1013 A1 Journal article (refereed), original research -
No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
Scott RA, Chu AY, Grarup N, ManningAK, Hivert M-F, Shungin D, Tönjes A, Yesupriya A, Barnes D, Bouatia-Naji N, Glazer NL, Jackson AU, Kutalik Z, Lagou V, Marek D, Rasmussen-Torvik LJ, Stringham HM, Tanaka T, Aadah M, Arking DE et.al.. 2012. Diabetes. 61: 1291-1296 A2 Review article, Literature review, Systematic review -
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, Beekman M, Coassin S, Lohman K, Qi L, Kanoni S et.al.. 2012. PLoS genetics. 8: e1002607 A1 Journal article (refereed), original research -
A Common Variant in TFB1M Is Associated with Reduced Insulin Secretion and Increased Future Risk of Type 2 Diabetes
Koeck T, Olsson AH, Nitert MD, Sharoyko VV, Ladenvall C, Kotova O, Reiling E, Rönn T, Parikh H, Taneera J, Eriksson JG, Metodiev MD, Larsson NG, Balhuizen A, Luthman H, Stančáková A, Kuusisto J, Laakso M, Poulsen P, Vaag A. 2011. Cell metabolism. 13: 80-91 A1 Journal article (refereed), original research -
A novel surrogate index for hepatic insulin resistance
Vangipurapu J, Stancakova A, Kuulasmaa T, Paananen J, Kuusisto J, EGIR-RISC Study Group, Ferrannini E, Laakso M. 2011. Diabetologia. 54: 540-543 A1 Journal article (refereed), original research -
A role for coding functional variants in HNF4A in type 2 diabetes susceptibility
Jafar-Mohammadi B, Groves CJ, Gjesing AP, Herrera BM, Winckler W, Stringham HM, Morris AP, Lauritzen T, Doney ASF, Morris AD, Weedon MN, Swift AJ, Kuusisto J, Laakso M, Altshuler D, Hattersley AT, Collins FS, Boehnke M, Hansen T, Pedersen O, Palmer CNA, Frayling TM, DIAGRAM Consortium, Gloyn AL, McCarthy MI. 2011. Diabetologia. 54: 111-119 A1 Journal article (refereed), original research -
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.
Fox ER, Young JH, Li Y, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC, Ganesh S, Kutlar A, Ramachandran VS, Polak JF, Fabsitz RR, Dries DL, Farlow DN, Redline S, Adeyemo A, Hirschorn JN, Sun YV, Wyatt SB, Penman AD, Palmas W, Rotter JI, Townsend RR, Doumatey AP, Tayo BO, Mosley TH Jr, Lyon HN, Kang SJ, Rotimi CN, Cooper RS, Franceschini N, Curb JD, Martin LW, Eaton CB, Kardia SL, Taylor HA, Caulfield MJ, Ehret GB, Johnson T; International Consortium for Blood Pressure Genome-wide Assoc. 2011. Human molecular genetics. 20: 2273-2284 A1 Journal article (refereed), original research -
Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men
Vangipurapu J, Stancakova A, Pihlajamäki J, Kuulasmaa TM, Kuulasmaa T, Paananen J, Kuusisto J, Ferrannini E, Laakso M. 2011. Diabetologia. 54: 563-571 A1 Journal article (refereed), original research -
Cardiac MRI assessed left ventricular hypertrophy in differentiating hypertensive heart disease from hypertrophic cardiomyopathy attributable to a sarcomeric gene mutation
Sipola P, Magga J, Husso M, Jääskeläinen P, Peuhkurinen K, Kuusisto J. 2011. European radiology. 21: 1383-1389 A1 Journal article (refereed), original research -
Effects of 34 Risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men
Stancáková A, Paananen J, Soininen P, Kangas AJ, Bonnycastle LL, Morken MA, Collins FS, Jackson AU, Boehnke ML, Kuusisto J, Ala-Korpela M, Laakso M. 2011. Diabetes. 60: 1608-1616 A1 Journal article (refereed), original research -
Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles
Haas BE, Weissglas-Volkov D, Aguilar-Salinas CA, Nikkola E, Vergnes L, Cruz-Bautista I, Riba L, Stancakova A, Kuusisto J, Soininen P, Kangas AJ, Ala-Korpela M, Tusie-Luna T, Laakso M, Pajukanta P. 2011. Arteriosclerosis, thrombosis, and vascular biology. 31: 1201-1207 A1 Journal article (refereed), original research -
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O'Reilly PF, Amin N, Bragg-Gresham JL, Teumer A, Glazer NL, Launer L, Zhao JH et. al.. 2011. Nature. 478: 103-109 A1 Journal article (refereed), original research -
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
Kilpeläinen TO, Zillikens MC, Stančáková A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L, Styrkarsdottir U, Zhou Y, Smith AV, Zhao JH, Amin N, Vedantam S, Shin SY, Haritunians T, Fu M, Feitosa MF, Kumari M et al.. 2011. Nature genetics. 43: 753-760 A1 Journal article (refereed), original research -
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, Nalls MA, Clark JM, Mitchell BD, Shuldiner AR, Butler JL, Tomas M, Hoffmann U, Hwang SJ, Massaro JM, O'Donnell CJ, Sahani DV, Salomaa V, Schadt EE, Schwartz SM, Siscovick DS; NASH CRN; GIANT Consortium; MAGIC Investigators (including M. Laakso), Voight BF, Carr JJ, Feitosa MF, Harris TB, Fox CS, Smith AV, Kao WH, Hirschhorn JN, Borecki IB; GOLD Consortium:. 2011. PLoS genetics. 7: e1001324 A1 Journal article (refereed), original research -
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME, Bouatia-Naji N, Dimas AS, Nica A, Wheeler E, Chen H, Voight BF, Taneera J, Kanoni S, Peden JF, Turrini F, Gustafsson S, Zabena C, et al. 2011. Diabetes. 60: 2624-2534 A1 Journal article (refereed), original research -
Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B
Hribal ML, Presta I, Procopio T, Marini MA, Stančáková A, Kuusisto J, Andreozzi F, Hammarstedt A, Jansson PA, Grarup N, Hansen T, Walker M, Stefan N, Fritsche A, Häring HU, Pedersen O, Smith U, Laakso M, Sesti G; on behalf of the EUGENE2 Consortium. 2011. Diabetologia. 54: 795-802 A1 Journal article (refereed), original research -
Late gadolinium enhanced cardiovascular magnetic resonance of lamin A/C gene mutation related dilated cardiomyopathy
Holmström M, Kivistö S, Heliö T, Jurkko R, Kaartinen M, Antila M, Reissell E, Kuusisto J, Kärkkäinen S, Peuhkurinen K, Koikkalainen J, Lötjönen J, Lauerma K. 2011. Journal of cardiovascular magnetic resonance. 13: 30 A1 Journal article (refereed), original research -
Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children
Kilpeläinen Tuomas O, Qi Lu, Brage Soren, Sharp Stephen J., Sonestedt Emily, Demerath Ellen, Ahmad Tariq, Mora Samia, Kaakinen Marika, Sandholt Camilla H, Holzapfel Christina, Autenrieth Christine S., Hyppönen Elina, Cauchi Stéphane , He Meian, Kutalik Zoltan, Kumari Meena, Stancaková Alena, Meidtner Karina, Balkau Beverley et al.. 2011. PLoS medicine. 8: e1001116 A1 Journal article (refereed), original research -
Pleiotropic Effects of GIP on Islet Function Involves Osteopontin
Lyssenko V, Eliasson L, Kotova O, Pilgaard K, Wierup N, Salehi A, Wendt A, Jonsson A, De Marinis YZ, Berglund LM, Taneera J, Balhuizen A, Hansson O, Osmark P, Dunér P, Brøns C, Stancáková A, Kuusisto J, Bugliani M, Saxena R, et al.. 2011. Diabetes. 60: 2424-2433 A1 Journal article (refereed), original research -
Prevalence of Anderson-Fabry disease in patients with hypertrophic cardiomyopathy: the European Anderson-Fabry disease study
Elliott P, Baker R, Pasquale F, Quarta G, Ebrahim H, Mehta AB, Hughes DA on behalf of the ACES study group. 2011. Heart. 97: 1957-1960 A1 Journal article (refereed), original research -
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome
Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stančáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, Farese RV Jr, Kahn CR, et al.. 2011. Molecular cell. 44: 177-190 A1 Journal article (refereed), original research -
Serum lipidomics meets cardiac magnetic resonance imaging: profiling of subjects at risk of dilated cardiomyopathy
Sysi-Aho M, Koikkalainen J, Seppänen-Laakso T, Maartinen M, Kuusisto J, Peuhkurinen K, Kärkkäinen S, Antila M, Lauerma K, Reissell E, Jurkko R, Lötjönen J, Heliö T, Oresic M. 2011. PLoS ONE. 6: e15744 A1 Journal article (refereed), original research -
The Birth Weight Lowering C-Allele of rs900400 Near LEKR1 and CCNL1 Associates with Elevated Insulin Release following an Oral Glucose Challenge
Andersson EA, Harder MN, Pilgaard K, Pisinger C, Stančáková A, Kuusisto J, Grarup N, Færch K, Poulsen P, Witte DR, Jørgensen T, Vaag A, Laakso M, Pedersen O, Hansen T. 2011. PLoS ONE. 6: e27096 A1 Journal article (refereed), original research -
The Lin28/let-7 axis regulates glucose metabolism
Zhu H, Shyh-Chang N, Segrè AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, Urbach A, Thornton JE, Triboulet R, Gregory RI; DIAGRAM Consortium; MAGIC Investigators, Altshuler D, Daley GQ. 2011. Cell. 147: 81-94 A1 Journal article (refereed), original research -
Association of the FTO gene variant (rs9939609) with cardiovascular disease in men with abnormal glucose metabolism - The Finnish Diabetes Prevention Study
Lappalainen T, Kolehmainen M, Schwab US, Tolppanen AM, Stančáková A, Lindström J, Eriksson JG, Keinänen-Kiukaanniemi S, Aunola S, Ilanne-Parikka P, Herder C, Koenig W, Gylling H, Kolb H &Tuomilehto J for the Finnish diabetes prevention study group. 2010. Nutrition metabolism and cardiovascular diseases. 2011/21: 691-698/2011 A1 Journal article (refereed), original research -
Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity. Lessons from the METSIM study.
Gylling H, Hallikainen M, Pihlajamaki J, Simonen P, Kuusisto J, Laakso M, Miettinen TA.. 2010. Journal of lipid research. 51: 2422-2427 A1 Journal article (refereed), original research -
Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose
Li X, Shu Y-H, Xiang AH, Trigo E, Kuusisto J, Hartiala J, Swift AJ, Kawakubo M, Stringham HM, Bonnycastle LL, Lawrence JM, Laakso M, Allayee H, Buchanan TA, Watanabe RM. 2009. Diabetes. 58: 2946-2953 A1 Journal article (refereed), original research -
Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men
Stancáková A, Kuulasmaa T, Paananen J, Jackson AU, Bonnycastle LL, Collins FS, Boehnke M, Kuusisto J, Laakso M. 2009. Diabetes. 58: 2129-2136 A1 Journal article (refereed), original research -
Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes
Müssig K, Staiger H, Machicao F, Stancáková A, Kuusisto J, Laakso M, Thamer C, Machann J, Schick F, Claussen CD, Stefan N, Fritsche A, Häring H-U. 2009. Journal of clinical endocrinology and metabolism. 94: 1353-1360 A1 Journal article (refereed), original research -
Cardiac sympathetic activity is associated with inflammation and neurohumoral activation in patients with idiopathic dilated cardiomyopathy
Turpeinen AK, Vanninen E, Magga J, Tuomainen P, Kuusisto J, Sipola P, Punnonen K, Vuolteenaho O, Peuhkurinen K. 2009. Clinical physiology and functional imaging. 29: 414-419 A1 Journal article (refereed), original research -
Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men
Stancáková A, Javorský M, Kuulasmaa T, Haffner SM, Kuusisto J, Laakso M. 2009. Diabetes. 58: 1212-1221 A1 Journal article (refereed), original research -
Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects
Weyrich P, Staiger H, Stancáková A, Schäfer SA, Kirchhoff K, Ullrich S, Ranta F, Gallwitz B, Stefan N, Machicao F, Kuusisto J, Laakso M, Fritsche A, Häring H-U. 2009. Bmc medical genetics. 10: 77 A1 Journal article (refereed), original research -
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
Lyssenko V, Nagorny CLF, Erdos MR, Wierup N, Jonsson A, Spégel P, Bugliani M, Saxena R, Fex M, Pulizzi N, Isomaa B, Tuomi T, Nilsson P, Kuusisto J, Tuomilehto J, Boehnke M..., Laakso M, Marchetti P, Watanabe RM, Mulder H, Groop L. 2009. Nature genetics -
Common variants at 30 loci contribute to polygenic dyslipidemia
Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T..., Kuusisto J, Bergman RN..., Laakso M, Ferrucci L, Scheet P..., Dupuis J, de Bakker PI, O'Donnell CJ, Chambers JC, Kooner JS. 2009. Nature genetics. 41: 56-65 A1 Journal article (refereed), original research -
Galanin preproprotein is associated with elevated plasma triglycerides
Plaisier CL, Kyttälä M, Weissglas-Volkov D, Sinsheimer JS, Huertas-Vazquez A..., Pullinger CR, Malloy MJ, Kane JP, Cruz-Bautista I, Herrera MF, Aguilar-Salinas C, Kuusisto J, Laakso M, Taskinen MR, van der Kallen CJ, Pajukanta P. 2009. Arteriosclerosis, thrombosis, and vascular biology. 29: 147-152 A1 Journal article (refereed), original research -
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution
Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM..., Cherkas L, Chines P, Coin L, Cooper C, Crawford G, Doering A, Dominiczak A, Doney..., Laakso M, Kuusisto J. 2009. PLoS genetics. 5: e1000508 A1 Journal article (refereed), original research -
Genome-wide association study identifies eight loci associated with blood pressure
Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS..., Lucas G, Kuusisto J, Burton PR, Hadley D, McArdle WL, Wellcome TRUST Case Control Consortium, Brown M, Dominiczak A, Newhouse SJ, Samani NJ..., Laakso M. 2009. Nature genetics. 41: 666-676 A1 Journal article (refereed), original research -
Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics
Koutnikova H, Laakso M, Lu L, Combe R, Paananen J, Kuulasmaa T, Kuusisto J, Häring H-U, Hansen T, Pedersen O, Smith U, Hanefeld M, Williams RW, Auwerx J. 2009. PLoS genetics. 5: e100591 A1 Journal article (refereed), original research -
Parental origin of sequence variants associated with complex diseases
Kong A, Steinthorsdottir V, Masson G, Thorleifsson G..., ...Johannsson OT, Hreidarsson AB, Sigurdsson G, DIAGRAM Consortium, Laakso M, Kuusisto J. 2009. Nature. 462: 868-874 A1 Journal article (refereed), original research -
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N..., Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Kuusisto J, Laakso M. 2009. Nature genetics. 41: 25-34 A1 Journal article (refereed), original research -
The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels
Meex SJR, Weissglas-Volkov D, van der Kallen CJH, Thuerauf DJ, van Greevenbroek MMJ, Schalkwijk CG, Stehouwer CDA, Feskens EJM, Heldens L, Ayoubi TA, Hofker MH, Wouters BG..., Taskinen M-R, Kuusisto J, Laakso M, de Bruin TWA.... 2009. Arteriosclerosis, thrombosis, and vascular biology. 29: 1322-1327 A1 Journal article (refereed), original research -
Underlying genetic models of inheritance in established type 2 diabetes associations
Salanti G, Southam L, Altshuler D, Ardlie K, Barroso I, Boehnke M, Cornelis MC, Frayling TM, Grallert H, Grarup N, Groop L, Hansen T, Hattersley AT, Hu FB, Hveem K, Illig T, Kuusisto J, Laakso M, Langenberg C.... 2009. American journal of epidemiology. 170: 537-545 A1 Journal article (refereed), original research -
Variants in MTNR1B influence fasting glucose levels
Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, Kaakinen M, Lyssenko V, Chen WM, Ahmadi K..., Kuusisto J, Laakso M. 2009. Nature genetics. 41: 77-81 A1 Journal article (refereed), original research -
Clinical significance of troponin I efflux and troponin autoantibodies in patients with dilated cardiomyopathy
Miettinen KH, Eriksson S, Magga J, Tuomainen P, Kuusisto J, Vanninen EJ, Turpeinen A, Punnonen KR, Pettersson K, Peuhkurinen KJ. 2008. Journal of cardiac failure. 14: 481-488 A1 Journal article (refereed), original research -
Cytokines, interstitial collagen and ventricular remodelling in dilated cardiomyopathy
Timonen P, Magga J, Risteli J, Punnonen K, Vanninen E, Turpeinen A, Tuomainen P, Kuusisto J, Vuolteenaho O, Peuhkurinen K. 2008. International journal of cardiology. 124: 293-300 A1 Journal article (refereed), original research -
Early familial dilated cardiomyopathy: Identification with determination of disease state parameter from cine MR image data
Koikkalainen JR, Antila M, Lötjönen JMP, Heliö T, Lauerma K, Kivistö SM, Sipola P, Kaartinen MA, Kärkkäinen STJ, Reissell E, Kuusisto J, Laakso M, Oresic M, Nieminen MS, Peuhkurinen KJ. 2008. Radiology. 249: 88-96 A1 Journal article (refereed), original research -
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Zeggini E, Scott LJ, Saxena R, Voight BF, for the Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Laakso M, Kuusisto J. 2008. Nature genetics. 40: 638-645 A1 Journal article (refereed), original research -
Significance of plasma levels of N-Terminal pro-B-type natriuretic peptide on left ventricular remodeling in non-obstructive hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene
Magga J, Sipola P, Vuolteenaho O, Risteli J, Jääskeläinen P, Peuhkurinen K, Kuusisto J. 2008. American journal of cardiology. 101: 1185-1190 A1 Journal article (refereed), original research -
Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance
Stancáková A, Pihlajamäki J, Kuusisto J, Stefan N, Fritsche A, Häring H, Andreozzi F, Succurro E, Sesti G, Boesgaard TW, Hansen T, Pedersen O, Jansson PA, Hammarstedt A, Smith U, Laakso M, for the EUGENE2 Consortium. 2008. Journal of clinical endocrinology and metabolism. 93: 1924-1930 A1 Journal article (refereed), original research -
The metabolic syndrome predicts incident stroke: a 14-year follow-up study in elderly people in Finland
Wang J, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M, Kuusisto J. 2008. Stroke. 39: 1078-1083 A1 Journal article (refereed), original research -
Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, AND METSIM studies
Friedrich B, Weyrich P, Stancakova A, Wang J, Kuusisto J, Laakso M, Sesti G, Succurro E, Smith U, Hansen T, Pedersen O, Machicao F, Schäfer S, Lang F, Risler T, Ullrich S, Stefan N, Fritsche A, Häring H-U. 2008. PLoS ONE. 3: e3506 A1 Journal article (refereed), original research -
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
Chen W-M, Erdos MR, Jackson AU..., Kuusisto J, Ebrahim S..., Laakso M. 2008. Journal of clinical investigation. 118: 2620-2628 A1 Journal article (refereed), original research -
WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels
Lee JC, Weissglas-Volkov D, Kyttäjä M, Dastani Z, Cantor RM, Sobel EM, Plaisier CL, Engert JC, van Greenvenbroek MMJ, Kane JP, Malloy MJ..., Kuusisto J, Laakso M, Taskinen M-R, Genest J, Pajukanta P. 2008. American journal of human genetics. 83: 180-192 A1 Journal article (refereed), original research -
Atherosclerosis and cardiovascular risk reduction with PPAR agonists
Kuusisto J, Andrulionyte L, Laakso M, Laakso M. 2007. Current atherosclerosis reports. 9: 274-280 A2 Review article, Literature review, Systematic review -
Cerebrovascular disease in type 2 diabetes
Laakso M, Kuusisto J. Teoksessa: Grepaldi G, Tiengo A, Avogaro A(toim.) , 2007. The Metabolic Syndrome: The Road Map from Inflammation to Cardiovascular Disease. Proceedings ot the 9th European Symposium on Metabolism. s. 65-69. A4 Conference proceedings -
Metabolic syndrome and incident end-stage peripheral vascular disease. A 14-year follow-up study in elderly Finns
Wang J, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M, Kuusisto J. 2007. Diabetes care. 30: 3099-3104 A1 Journal article (refereed), original research -
Myocardial perfusion, oxidative metabolism, and free fatty acid uptake in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene: a positron emission tomography study
Tuunanen H, Kuusisto J, Toikka J, Jääskeläinen P, Marjamäki P, Peuhkurinen K, Viljanen T, Sipola P, Stolen KQ, Hannukainen J, Nuutila P, Laakso M, Knuuti J, Laakso M. 2007. Journal of nuclear cardiology. 14: 354-365 A1 Journal article (refereed), original research -
Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans
Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Kuusisto J, Laakso M. 2007. Obesity. 15: 2902-2907 A1 Journal article (refereed), original research -
The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns
Wang J, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M, Kuusisto J. 2007. European heart journal. 28: 857-864 A1 Journal article (refereed), original research -
Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion
Wang J, Kuusisto J, Vänttinen M, Kuulasmaa T, Lindström J, Tuomilehto J, Uusitupa M, Laakso M, Laakso M. 2007. Diabetologia. 50: 1192-1200 A1 Journal article (refereed), original research -
Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzhimer¿s disease in the Finnish population
Koivisto AM, Helisalmi S, Pihlajamäki J, Hiltunen M, Koivisto K, Moilanen L, Kuusisto J, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso M, Soininen H, Koivisto AM, Helisalmi S, Hiltunen M, Soininen H, Laakso M. 2006. Dementia and geriatric cognitive disorders. 22: 449-453 A1 Journal article (refereed), original research -
Association of metabolic syndrome with Alzheimer disease: a population-based study
Vanhanen M, Koivisto K, Moilanen L, Helkala E-L, Hänninen T, Soininen H, Kervinen K, Kesäniemi YA, Laakso M, Kuusisto J, Soininen H. 2006. Neurology. 67: 843-847 A1 Journal article (refereed), original research -
Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes
Pihlajamäki J, Salmenniemi U, Vänttinen M, Ruotsalainen E, Kuusisto J, Vauhkonen I, Kainulainen S, Ng MCY, Cox NJ, Bell CI, Laakso M, Laakso M. 2006. Diabetologia. 49: 1560-1566 A1 Journal article (refereed), original research -
Diastolic dysfunction without left ventricular hypertrophy is an early finding in children with hypertrophic cardiomyopathy-causing mutations in the beeta-myosin heavy chain, alfa-tropomyosin, and myosin-binding protein C genes
Poutanen T, Tikanoja T, Jääskeläinen P, Jokinen E, Silvast A, Laakso M, Kuusisto J, Laakso M. 2006. American heart journal. 151: 725.e1-725.e9 A1 Journal article (refereed), original research -
Myocardial late gadolinium enhancement is associated with raised serum amino-terminal propeptide of type III collagen concentrations in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha tropomyosin gene:
Sipola P, Peuhkurinen K, Lauerma K, Husso M, Jääskeläinen P, Laakso M, Aronen HJ, Risteli J, Kuusisto J, Laakso M. 2006. Heart -
Novel mutations in the lamin A/C gene in heart transplant recipients with end stage dilated cardiomyopathy
Kärkkäinen S, Reissell E, Heliö T, Kaartinen M, Tuomainen P, Toivonen L, Kuusisto J, Kupari M, Nieminen MS, Laakso M, Peuhkurinen K, Laakso M. 2006. Heart. 92: 524-526 A1 Journal article (refereed), original research -
Atherosclerosis-like lesions of the aortic valve are common in adults of all ages: a necropsy study
Kuusisto J, Räsänen K, Särkioja T, Alarakkola E, Kosma V-M. 2005. Heart. 91: 576-582 A1 Journal article (refereed), original research -
Cine MR imaging of myocardial contractile impairment in patients with hypertrophic cardiomyopathy attributable to Asp175Asn mutation in the alpha-tropomyosin gene
Sipola P, Lauerma K, Jääskeläinen P, Laakso M, Peuhkurinen K, Manninen H, Aronen HJ, Kuusisto J, Laakso M. 2005. Radiology. 236: 815- 824 A1 Journal article (refereed), original research -
Insulin resistance and coronary heart disease
Laakso M, Kuusisto J. Teoksessa: Serrano Ríos M, Caro JF, Carraro R, Gutiérrez Fuentes JA(toim.) , 2005. The Metabolic Syndrome at the Beginning of the XXIst Century. s. 369-382. Elsevier A3 Book section, Chapters in research books -
Sydämen vajaatoiminta - monimuotoinen haaste
Kuusisto J. 2005. Lääkärilehti -
A novel mutation, Ser143Pro, in the lamin A/C gene is common in finnish patients with familial dilated cardiomyopathy
Kärkkäinen S, Heliö T, Miettinen R, Tuomainen P, Peltola P, Rummukainen J, Ylitalo K, Kaartinen M, Kuusisto J, Toivonen L, Nieminen MS, Laakso M, Peuhkurinen K, Laakso M. 2004. European heart journal. 25: 885-893 A1 Journal article (refereed), original research -
Genetics of hypertrophic cardiomyopathy in eastern Finland: few founder mutations with benign or intermediary phenotypes
Jääskeläinen P, Miettinen R, Kärkkäinen P, Toivonen L, Laakso M, Kuusisto J. 2004. Annals of medicine. 36: 23-32 A2 Review article, Literature review, Systematic review -
Inducibility of life-threatening ventricular arrhythmias is related to maximum left ventricular thickness and clinical markers of sudden cardiac death in patients with hypertrophic cardiomyopathy attridutable to the Asp175Asn mutation in the Alfa-tropomyo
Hedman A, Hartikainen J, Vanninen E, Laitinen T, Jääskeläinen P, Laakso M, Peuhkurinen K, Kuusisto J, Laakso M. 2004. Journal of molecular and cellular cardiology. 36: 91-99 A1 Journal article (refereed), original research -
The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain
Rutanen J, Pihlajamäki J, Karhapää P, Vauhkonen I, Kuusisto J, Moilanen Mykkänen L, Laakso M, Laakso M. 2004. Obesity. 12: 1060-1066 A1 Journal article (refereed), original research -
Two novel mutations in the beta-myosin heavy chain gene associated with dilated cardiomyopathy
Kärkkäinen S, Heliö T, Jääskeläinen P, Miettinen R, Tuomainen P, Ylitalo K, Kaartinen M, Reissell E, Toivonen L, Nieminen MS, Kuusisto J, Laakso M, Peuhkurinen K. 2004. European journal of heart failure. 6: 861-868 A1 Journal article (refereed), original research -
A novel mutation, Arg71Thr, in the delta-sarcoglycan gene is associated with dilated cardiomyopathy
Kärkkäinen S, Miettinen R, Tuomainen P, Kärkkäinen P, Heliö T, Reissell E, Kaartinen M, Toivonen L, Nieminen MS, Kuusisto J, Laakso M, Peuhkurinen K, Laakso M. 2003. Journal of molecular medicine: jmm. 81: 795-800 A1 Journal article (refereed), original research -
Cardiac adrenergic activity is associated with left ventricular hypertrophy in genetically homogenous subjects with hypertrophic cardiomyopathy
Sipola P, Vanninen E, Aronen HJ, Lauerma K, Simula S, Jääskeläinen P, Laakso M, Peuhkurinen K, Kuusisto J, Kuikka JT, Laakso M. 2003. Journal of nuclear medicine. 44: 487-493 A1 Journal article (refereed), original research -
First-pass MR imaging in the assessment of perfusion impairment in patients with hypertrophic cardiomyopathy and the asp 175asn mutation of the alfa-tropomyosin gene
Sipola P, Lauerma K, Husso-Saastamoinen M, Kuikka JT, Vanninen E, Laitinen T, Manninen H, Niemi P, Peuhkurinen K, Jääskeläinen P, Laakso M, Kuusisto J, Aronen HJ, Laakso M. 2003. Radiology. 226: 129-137 A1 Journal article (refereed), original research -
Understanding patient needs. Diabetology for cardiologists
Laakso M, Kuusisto J. 2003. European heart journal supplements. 5 (Suppl B): B5-B13 A1 Journal article (refereed), original research -
Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland
Jääskeläinen P, Kuusisto J, Miettinen R, Kärkkäinen P, Kärkkäinen S, Heikkinen S, Peltola P, Pihlajamäki J, Vauhkonen I, Laakso M. 2002. Journal of molecular medicine: jmm. 80: 412-422 A1 Journal article (refereed), original research -
No variants in the cardiac actin gene in Finnish patients with dilated or hypertrophic cardiomyopathy
Kärkkäinen S, Peuhkurinen K, Jääskeläinen P, Miettinen R, Kärkkäinen P, Kuusisto J, Laakso M. 2002. American heart journal. 143: 11-14 A1 Journal article (refereed), original research -
APOE-epsilon4 is associated with weight loss in women with AD. A population-based study
Vanhanen M, Kivipelto M, Koivisto K, Kuusisto J, Mykkänen L, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso MP, Soininen H, Laakso M. 2001. Neurology. 56: 655-659 A1 Journal article (refereed), original research -
Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men
Kuusisto J, Lempiäinen P, Mykkänen L, Laakso M. 2001. Diabetes care. 24: 1629-1633 A1 Journal article (refereed), original research -
New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes
Wang H, Rissanen J, Miettinen R, Kärkkäinen P, Kekäläinen P, Kuusisto J, Mykkänen L, Karhapää P, Laakso M. 2001. Diabetes. 50: 1949-1951 A1 Journal article (refereed), original research -
Apolipoprotein E phenotype alone does not influence survival in Alzheimer's disease: a population-based longitudinal study
Koivisto AM, Lempiäinen P, Koivisto K, Helkala E-L, Mykkänen L, Kuusisto J, Kervinen K, Kesäniemi YA, Laakso M, Soininen H. 2000. Neuroepidemiology. 19: 327-332 A1 Journal article (refereed), original research -
Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase. Cloning, genomic structure, and screening for variants in patients with type 2 diabetes
Kossila M, Sinkovic M, Kärkkäinen P, Laukkanen MO, Miettinen R, Rissanen J, Kekäläinen P, Kuusisto J, Ylä-Herttuala S, Laakso M. 2000. Diabetes. 49: 1740-1743 A1 Journal article (refereed), original research -
Hypertrofinen kardiomyopatia
Kuusisto J. Teoksessa: Heikkilä J, Huikuri H, Luomanmäki K, Nieminen MS, Peuhkurinen K(toim.) , 2000. Kardiologia. s. 853-865. Duodecim D2 Article in a professional book (incl. an introduction by the editor) -
Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin
Rissanen J, Markkanen A, Kärkkäinen P, Pihlajamäki J, Kekäläinen P, Mykkänen L, Kuusisto J, Karhapää P, Niskanen L, Laakso M. 2000. Diabetes care. 23: 70-73 A1 Journal article (refereed), original research -
The Pro12Ala substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with d
Pihlajamäki J, Miettinen R, Valve R, Karjalainen L, Mykkänen L, Kuusisto J, Deeb S, Auwerx J, Laakso M. 2000. Atherosclerosis. 151: 567-574 A1 Journal article (refereed), original research -
Variants in the hepatocyte nuclear factor-1alfa and -4alfa genes in Finnish and Chinese subjects with late-onset type 2 diabetes
Rissanen J, Wang H, Miettinen R, Kärkkäinen P, Kekäläinen P, Mykkänen L, Kuusisto J, Karhapää P, Niskanen L, Uusitupa M, Laakso M. 2000. Diabetes care. 23: 1533-1538 A1 Journal article (refereed), original research -
Insulin resistance syndrome and Alzheimer's disease: the summary of Finnish studies
Kuusisto J, Koivisto K, Mykkänen L, Helkala E, Vanhanen M, Hänninen T, Kervinen K, Kesäniemi YA, Riekkinen P, Laakso M. Teoksessa: Vellas B, Fitten LJ(toim.) , 1999. Research and Practice in Alzheimer's Disease. s. 135-139. Serdi Publisher A3 Book section, Chapters in research books -
Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men
Lempiäinen P, Mykkänen L, Pyörälä K, Laakso M, Kuusisto J. 1999. Circulation. 100: 123-128 A1 Journal article (refereed), original research -
LDL size and risk of coronary heart disease in elderly men and women
Mykkänen L, Kuusisto J, Haffner SM, Laakso M, Austin MA. 1999. Arteriosclerosis, thrombosis, and vascular biology. 19: 2742-2748 A1 Journal article (refereed), original research -
Prandial glucose regulation and cardiovascular disease in Type 2 diabetes
Kuusisto J, Laakso M. 1999. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. SUPPLEMENT. 29: 7-11 A1 Journal article (refereed), original research -
Sarkomeerin geenimutaatiot - hypertrofisen kardiomyopatian syy
Kuusisto J, Jääskeläinen P, Laakso M. 1999. Duodecim -
Simultaneous hypertrophic cardiomyopathy and ventricular septal defect in children
Tikanoja T, Jääskeläinen P, Laakso M, Kuusisto J. 1999. American journal of cardiology. 84: 485-486 A1 Journal article (refereed), original research -
The cardiac troponin I gene is not associated with hypertrophic cardiomyopathy in patients from Eastern Finland
Jääskeläinen P, Miettinen R, Silvennoinen K, Vauhkonen I, Laakso M, Kuusisto J. 1999. Journal of molecular and cellular cardiology. 31: 2031-2036 A1 Journal article (refereed), original research -
Type-2 diabetes and cognitive function in a non-demented population
Vanhanen M, Kuusisto J, Koivisto K, Mykkänen L, Helkala E-L, Hänninen T, Riekkinen P Sr, Soininen H, Laakso M. 1999. Acta neurologica scandinavica. 100: 97-101 A1 Journal article (refereed), original research -
A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
Deeb SS, Fajas L, Nemoto M, Pihlajamäki J, Mykkänen L, Kuusisto J, Laakso M, Fujimoto W, Auwerx J. 1998. Nature genetics -
Can degenerative aortic valve stenosis be related to persistent Chlamydia pneumoniae infection?
Juvonen J, Juvonen T, Laurila A, Kuusisto J, Alarakkola E, Särkioja T, Bodian CA, Kairaluoma MI, Saikku P. 1998. Annals of internal medicine. 128: 741-744 A1 Journal article (refereed), original research -
Cognitive function in an elderly population with persistent impaired glucose tolerance
Vanhanen M, Koivisto K, Kuusisto J, Mykkänen L, Helkala E-L, Hänninen T, Riekkinen P Sr, Soininen H, Laakso M. 1998. Diabetes care. 21: 398-402 A1 Journal article (refereed), original research -
Glucokinase gene islet promoter region variant (G->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns
Rissanen J, Saarinen L, Heikkinen S, Kekäläinen P, Mykkänen L, Kuusisto J, Deeb SS, Laakso M. 1998. Diabetes care. 21: 1194-1197 A1 Journal article (refereed), original research -
The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population
Jääskeläinen P, Soranta M, Miettinen R, Saarinen L, Pihlajamäki J, Silvennoinen K, Tikanoja T, Laakso M, Kuusisto J. 1998. Journal of the american college of cardiology. 32: 1709-1716 A1 Journal article (refereed), original research -
Aorttaläppästenoosin patogeneesi selviämässä
Kuusisto J. 1997. Duodecim -
Association between features of the insulin resistance syndrome and Alzheimer`s disease independently of apolipoprotein E4 phenotype:cross sectional population based study
Kuusisto J, Koivisto K, Mykkänen L, Helkala E-L, Vanhanen M, Hänninen T, Kervinen K, Kesäniemi YA, Riekkinen PJ, Laakso M. 1997. BMJ international edition. 315: 1045-1049 A1 Journal article (refereed), original research -
Detection of Chlamydia pneumoniae in human nonrheumatic stenotic aortic valves
Juvonen J, Laurila A, Juvonen T, Alakärppä H, Surcel H-M, Lounatmaa K, Kuusisto J, Saikku P. 1997. Journal of the american college of cardiology. 29: 1054-1059 A1 Journal article (refereed), original research -
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease
Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, Van Duijn CM, for the APOE and Alzheimer Disease Meta Analysis Consorium, Koivisto K, Lehtovirta M, Riekkinen P Sr, Kuusisto J, Laakso M, Soininen H. 1997. JAMA : Journal of the American Medical Association. 278: 1349-1356 A1 Journal article (refereed), original research -
New variants in the glycogen synthase gene (GIn71His, Met416Val) in patients with NIDDM from eastern Finland
Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Mykkänen L, Kuusisto J, Kolle A, Laakso M. 1997. Diabetologia. 40: 1313-1319 A1 Journal article (refereed), original research -
Stability of age-associated memory impairment during a longitudinal population-based study
Helkala E-L, Koivisto K, Hanninen T, Vanhanen M, Kuusisto J, Mykkanen L, Laakso M, Riekkinen P Sr. 1997. Journal of the american geriatrics society -
The ala54thr polymorphism of the fatty acid binding protein 2 gene does not influence insulin sensitivity in Finnish nondiabetic and NIDDM subjects
Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Kuusisto J, Laakso M. 1997. Diabetes. 46: 711-712 A2 Review article, Literature review, Systematic review -
The trp64arg polymorphism of the beta3-adrenergic receptor gene
Rissanen J, Kuopusjärvi M, Pihlajamäki J, Sipiläinen R, Heikkinen S, Vanhala M, Kekäläinen P, Kuusisto J, Laakso M. 1997. Diabetes care. 20: 1319-1323 A1 Journal article (refereed), original research -
Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of 'degenerative' valvular aortic stenosis
O'Brien KD, Reichenbach DD, Marcovina SM, Kuusisto J, Alpers CE, Otto CM. 1996. Arteriosclerosis, thrombosis, and vascular biology. 16: 523-532 A1 Journal article (refereed), original research -
Epidemiological evidence for the association of hyperglycaemia and atheroslecrotic vascular disease in non-insulin-dependent diabetes mellitus
Laakso M, Kuusisto J. 1996. Annals of medicine. 28: 415-418 A2 Review article, Literature review, Systematic review -
Gender differences in left ventricular function at rest and with exercise in asymptomatic aortic stenosis
Legget ME, Kuusisto J, Healy NL, Fujioka M, Schwaegler RG, Otto CM. 1996. American heart journal. 131: 94-100 A1 Journal article (refereed), original research -
Hyperglykemia lisää sydän- ja verisuonitauteihin sairastuvuutta aikuistyypin diabeteksessa
Kuusisto J, Lehto S, Laakso M. 1996. Duodecim. 112: 1965-1966 A2 Review article, Literature review, Systematic review -
Memory functions in human subjects with different apolipoprotein E phenotypes during a 3-year population-based follow-up study
Helkala E-L, Koivisto K, Hänninen T, Vanhanen M, Kervinen K, Kuusisto J, Mykkänen L, Kesäniemi YA, Laakso M, Riekkinen P Sr. 1996. Neuroscience letters. 204: 177-180 A1 Journal article (refereed), original research -
Retroperitoneal fibrosis with antineutrophil cytoplasmic antibodies
Kaipiainen-Seppänen O, Jantunen E, Kuusisto J, Marin S. 1996. Journal of rheumatology. 23: 779-781 A1 Journal article (refereed), original research -
Risk Factors for Non-Insulin-Dependent Diabetes, Coronary Heart Disease and Stroke in Elderly Subjects
Kuusisto J. 1996. Kuopio University Publications D. Medical Sciences G5 Doctoral dissertation (article) -
Apolipoprotein E4 phenotype is not an important risk factor for coronary heart disease or stroke in elderly subjects
Kuusisto J, Mykkänen L, Kervinen K, Kesäniemi YA, Laakso M. 1995. Arteriosclerosis, thrombosis, and vascular biology. 15: 1280-1286 A1 Journal article (refereed), original research -
Glucokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance
Laakso M, Malkki M, Kekäläinen P, Kuusisto J, Mykkänen L, Deeb SS. 1995. Diabetes care. 18: 398-400 A1 Journal article (refereed), original research -
Hyperinsulinemic microalbuminuria: A new risk indicator for coronary heart disease
Kuusisto J, Mykkänen L, Pyörälä K, Laakso M. 1995. Circulation. 91: 831-837 A1 Journal article (refereed), original research -
Improvement of metabolic control does not normalize auditory brainstem latencies in subjects with insulin-dependent diabetes mellitus
Virtaniemi J, Kuusisto J, Karjalainen L, Karjalainen S, Laakso M. 1995. American journal of otolaryngology. 16: 172-176 A1 Journal article (refereed), original research -
Osteopontin is expressed in human aortic valvular lesions
O'Brien KD, Kuusisto J, Reichenbach DD, Ferguson M, Giachelli C, Alpers CE, Otto CM. 1995. Circulation. 92: 2163-2168 A1 Journal article (refereed), original research -
Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance
Laakso M, Malkki M, Kekäläinen P, Kuusisto J, Deeb SS. 1995. Diabetologia. 38: 617-622 A1 Journal article (refereed), original research -
Prospective study of small LDLs as a risk factor for non-insulin dependent diabetes mellitus in elderly men and women
Austin MA, Mykkänen L, Kuusisto J, Edwards KL, Nelson C, Haffner SM, Pyörälä K, Laakso M. 1995. Circulation. 92: 1770-1778 A1 Journal article (refereed), original research -
Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects
Mykkänen L, Haffner SM, Kuusisto J, Pyörälä K, Hales CN, Laakso M. 1995. Diabetologia. 38: 1176-1182 A1 Journal article (refereed), original research -
The association of apolipoprotein E polymorphism with memory: a population based study
Helkala E-L, Koivisto K, Hänninen T, Vanhanen M, Kervinen K, Kuusisto J, Mykkänen L, Kesäniemi YA, Laakso M, Riekkinen P Sr. 1995. Neuroscience letters. 191: 141-144 A1 Journal article (refereed), original research