Johanna Kuusisto

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Suzuki, Ken; Hatzikotoulas, Konstantinos; Southam, Lorraine; Taylor, Henry J.; Yin, Xianyong; Lorenz, Kim M.; Mandla, Ravi; Huerta-Chagoya, Alicia; Melloni, Giorgio E.M.; Kanoni, Stavroula; Rayner, Nigel W.; Bocher, Ozvan; Arruda, Ana Luiza; Sonehara, Kyuto; Namba, Shinichi; Lee, Simon S.K.; Preuss, Michael H.; Petty, Lauren E.; Schroeder, Philip; Vanderwerff, Brett; Kals, Mart; Bragg, Fiona; Lin, Kuang; Guo, Xiuqing; Zhang, Weihua; Yao, Jie; Kim, Young Jin; Graff, Mariaelisa; Takeuchi, Fumihiko. 2024. Nature. 627: 347-357

Cell-type composition affects adipose gene expression associations with cardiometabolic traits

Brotman, Sarah M; Oravilahti, Anniina; Rosen, Jonathan D; Alvarez, Marcus; Heinonen, Sini; van der Kolk, Birgitta; Silva, Lilian Fernandes; Perrin, Hannah J; Vadlamudi, Swarooparani; Pylant, Cortney; Deochand, Sonia; Basta, Patricia V; Valone, Jordan M; Narain, Morgan N; Stringham, Heather M; Boehnke, Michael; Kuusisto, Johanna; Love, Michael I; Pietiläinen, Kirsi H; Pajukanta, Päivi; Laakso, Markku; Mohlke, Karen L. 2023. Diabetes. 72: 1707-1718

Late-onset and classic phenotypes of Fabry disease in males with the GLA-Thr410Ala mutation

Valtola, Kati; Hedman, Marja; Kantola, Ilkka; Walls, Susanne; Helisalmi, Seppo; Maria, Maleeha; Raivo, Joose; Auray-Blais, Christiane; Kuusisto, Johanna. 2023. Open heart. 10:

SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase

Kettunen, Pinja; Lesnikova, Angelina; Räsänen, Noora; Ojha, Ravi; Palmunen, Leena; Laakso, Markku; Lehtonen, Šárka; Kuusisto, Johanna; Pietiläinen, Olli; Saber, Saber H; Joensuu, Merja; Vapalahti, Olli P; Koistinaho, Jari; Rolova, Taisia; Balistreri, Giuseppe. 2023. Journal of virology. 97: . e00144-23

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

Ramdas, Shweta; Judd, Jonathan; Graham, Sarah E.; Kanoni, Stavroula; Wang, Yuxuan; Surakka, Ida; Wenz, Brandon; Clarke, Shoa L.; Chesi, Alessandra; Wells, Andrew; Bhatti, Konain Fatima; Vedantam, Sailaja; Winkler, Thomas W.; Locke, Adam E.; Marouli, Eirini; Zajac, Greg J.M.; Wu, Kuan-Han H.; Ntalla, Ioanna; Hui, Qin; Klarin, Derek; Hilliard, Austin T.; Wang, Zeyuan; Xue, Chao; Thorleifsson, Gudmar; Helgadottir, Anna; Gudbjartsson, Daniel F.; Holm, Hilma; Olafsson, Isleifur; Hwang, Mi Yeong; Han,. 2022. American journal of human genetics. 109: 1366-1387

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Winkler, Thomas W.; Rasheed, Humaira; Teumer, Alexander; Gorski, Mathias; Rowan, Bryce X.; Stanzick, Kira J.; Thomas, Laurent F.; Tin, Adrienne; Hoppmann, Anselm; Chu, Audrey Y.; Tayo, Bamidele; Thio, Chris H. L.; Cusi, Daniele; Chai, Jin-Fang; Sieber, Karsten B.; Horn, Katrin; Li, Man; Scholz, Markus; Cocca, Massimiliano; Wuttke, Matthias; van der Most, Peter J.; Yang, Qiong; Ghasemi, Sahar; Nutile, Teresa; Li, Yong; Pontali, Giulia; Günther, Felix; Dehghan, Abbas; Correa, Adolfo; Parsa, Afshin. 2022. Communications biology. 5:

Effects of age, amyloid, sex, and APOE epsilon 4 on the CSF proteome in normal cognition

Wesenhagen, Kirsten E. J.; Gobom, Johan; Bos, Isabelle; Vos, Stephanie J. B.; Martinez-Lage, Pablo; Popp, Julius; Tsolaki, Magda; Vandenberghe, Rik; Freund-Levi, Yvonne; Verhey, Frans; Lovestone, Simon; Streffer, Johannes; Dobricic, Valerija; Bertram, Lars; Blennow, Kaj; Pikkarainen, Maria; Hallikainen, Merja; Kuusisto, Johanna; Laakso, Markku; Soininen, Hilkka; Scheltens, Philip; Zetterberg, Henrik; Teunissen, Charlotte E.; Visser, Pieter Jelle; Tijms, Betty M.; for the Alzheimer’s Disease Neur. 2022. Alzheimer's & dementia : diagnosis, assessment & disease monitoring. 14:

Genetic diversity fuels gene discovery for tobacco and alcohol use

Saunders, Gretchen R. B.; Wang, Xingyan; Chen, Fang; Jang, Seon-Kyeong; Liu, Mengzhen; Wang, Chen; Gao, Shuang; Jiang, Yu; Khunsriraksakul, Chachrit; Otto, Jacqueline M.; Addison, Clifton; Akiyama, Masato; Albert, Christine M.; Aliev, Fazil; Alonso, Alvaro; Arnett, Donna K.; Ashley-Koch, Allison E.; Ashrani, Aneel A.; Barnes, Kathleen C.; Barr, R. Graham; Bartz, Traci M.; Becker, Diane M.; Bielak, Lawrence F.; Benjamin, Emelia J.; Bis, Joshua C.; Bjornsdottir, Gyda; Blangero, John; Bleecker, Eug. 2022. Nature. 612: 720-724

Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies.

Gorski, Mathias; Rasheed, Humaira; Teumer, Alexander; Thomas, Laurent F.; Graham, Sarah E.; Sveinbjornsson, Gardar; Winkler, Thomas W.; Günther, Felix; Stark, Klaus J.; Chai, Jin-Fang; Tayo, Bamidele O.; Wuttke, Matthias; Li, Yong; Tin, Adrienne; Ahluwalia, Tarunveer S.; Ärnlöv, Johan; Åsvold, Bjørn Olav; Bakker, Stephan J.L.; Banas, Bernhard; Bansal, Nisha; Biggs, Mary L.; Biino, Ginevra; Böhnke, Michael; Boerwinkle, Eric; Bottinger, Erwin P.; Brenner, Hermann; Brumpton, Ben; Carroll, Robert J.. 2022. Kidney international. 102: 624-639

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Wang, Zhe; Emmerich, Andrew; Pillon, Nicolas J.; Moore, Tim; Hemerich, Daiane; Cornelis, Marilyn C.; Mazzaferro, Eugenia; Broos, Siacia; Ahluwalia, Tarunveer S.; Bartz, Traci M.; Bentley, Amy R.; Bielak, Lawrence F.; Chong, Mike; Chu, Audrey Y.; Berry, Diane; Dorajoo, Rajkumar; Dueker, Nicole D.; Kasbohm, Elisa; Feenstra, Bjarke; Feitosa, Mary F.; Gieger, Christian; Graff, Mariaelisa; Hall, Leanne M.; Haller, Toomas; Hartwig, Fernando P.; Hillis, David A.; Huikari, Ville; Heard-Costa, Nancy; Hol. 2022. Nature genetics. 54: 1332-1344

Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci

Yin, Xianyong; Chan, Lap Sum; Bose, Debraj; Jackson, Anne U; VandeHaar, Peter; Locke, Adam E; Fuchsberger, Christian; Stringham, Heather M; Welch, Ryan; Yu, Ketian; Fernandes Silva, Lilian; Service, Susan K; Zhang, Daiwei; Hector, Emily C; Young, Erica; Ganel, Liron; Das, Indraniel; Abel, Haley; Erdos, Michael R; Bonnycastle, Lori L; Kuusisto, Johanna; Stitziel, Nathan O; Hall, Ira M; Wagner, Gregory R; Ripatti, Samuli; Palotie, Aarno; Kang, Jian; Morrison, Jean; Burant, Charles F; Collins, Fran. 2022. Nature communications. 13: . 1644

Healthcare resource use of patients with transthyretin amyloid cardiomyopathy

Lauppe, Rosa; Liseth Hansen, Johan; Fornwall, Anna; Johansson, Katarina; Rozenbaum, Mark H; Strand, Anne Mette; Väkeväinen, Merja; Kuusisto, Johanna; Gude, Einar; Smith, J Gustav; Gustafsson, Finn. 2022. ESC heart failure. 9: 1636-1642

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Kanoni, Stavroula; Graham, Sarah E.; Wang, Yuxuan; Surakka, Ida; Ramdas, Shweta; Zhu, Xiang; Clarke, Shoa L.; Bhatti, Konain Fatima; Vedantam, Sailaja; Winkler, Thomas W.; Locke, Adam E.; Marouli, Eirini; Zajac, Greg J. M.; Wu, Kuan-Han H.; Ntalla, Ioanna; Hui, Qin; Klarin, Derek; Hilliard, Austin T.; Wang, Zeyuan; Xue, Chao; Thorleifsson, Gudmar; Helgadottir, Anna; Gudbjartsson, Daniel F.; Holm, Hilma; Olafsson, Isleifur; Hwang, Mi Yeong; Han, Sohee; Akiyama, Masato; Sakaue, Saori; Terao, Chika. 2022. Genome biology. 23: . 268

Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk

Yin, Xianyong; Bose, Debraj; Kwon, Annie; Hanks, Sarah C.; Jackson, Anne U.; Stringham, Heather M.; Welch, Ryan; Oravilahti, Anniina; Fernandes Silva, Lilian; Locke, Adam E.; Fuchsberger, Christian; Service, Susan K.; Erdos, Michael R.; Bonnycastle, Lori L.; Kuusisto, Johanna; Stitziel, Nathan O.; Hall, Ira M.; Morrison, Jean; Ripatti, Samuli; Palotie, Aarno; Freimer, Nelson B.; Collins, Francis S.; Mohlke, Karen L.; Scott, Laura J.; Fauman, Eric B.; Burant, Charles; Boehnke, Michael; Laakso, Ma. 2022. American journal of human genetics. 109: 1727-1741

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Mahajan, Anubha; Spracklen, Cassandra N.; Zhang, Weihua; Ng, Maggie C. Y.; Petty, Lauren E.; Kitajima, Hidetoshi; Yu, Grace Z.; Rüeger, Sina; Speidel, Leo; Kim, Young Jin; Horikoshi, Momoko; Mercader, Josep M.; Taliun, Daniel; Moon, Sanghoon; Kwak, Soo-Heon; Robertson, Neil R.; Rayner, Nigel W.; Loh, Marie; Kim, Bong-Jo; Chiou, Joshua; Miguel-Escalada, Irene; della Briotta Parolo, Pietro; Lin, Kuang; Bragg, Fiona; Preuss, Michael H.; Takeuchi, Fumihiko; Nano, Jana; Guo, Xiuqing; Lamri, Amel; Nak. 2022. Nature genetics. 54: 560-572

Multiparametric platform for profiling lipid trafficking in human leukocytes

Pfisterer, Simon G; Brock, Ivonne; Kanerva, Kristiina; Hlushchenko, Iryna; Paavolainen, Lassi; Ripatti, Pietari; Islam, Mohammad Majharul; Kyttälä, Aija; Di Taranto, Maria D; Scotto di Frega, Annalisa; Fortunato, Giuliana; Kuusisto, Johanna; Horvath, Peter; Ripatti, Samuli; Laakso, Markku; Ikonen, Elina. 2022. Cell reports : methods. 2:

Prevalence, characteristics, and mortality of patients with transthyretin amyloid cardiomyopathy in the Nordic countries

Lauppe, Rosa; Liseth Hansen, Johan; Fornwall, Anna; Johansson, Katarina; Rozenbaum, Mark H.; Strand, Anne Mette; Väkeväinen, Merja; Kuusisto, Johanna; Gude, Einar; Smith, J. Gustav; Gustafsson, Finn. 2022. ESC heart failure. 9: 2528-2537

Subcutaneous adipose tissue splice quantitative trait loci reveal differences in isoform usage associated with cardiometabolic traits

Brotman, Sarah M.; Raulerson, Chelsea K.; Vadlamudi, Swarooparani; Currin, Kevin W.; Shen, Qiujin; Parsons, Victoria A.; Iyengar, Apoorva K.; Roman, Tamara S.; Furey, Terrence S.; Kuusisto, Johanna; Collins, Francis S.; Boehnke, Michael; Laakso, Markku; Pajukanta, Päivi; Mohlke, Karen L.. 2022. American journal of human genetics. 109: 66-80

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

Goodrich, JK; Singer-Berk, M; Son, R; Sveden, A; Wood, J; England, E; Cole, JB; Weisburd, B; Watts, N; Caulkins, L; Dornbos, P; Koesterer, R; Zappala, Z; Zhang, H; Maloney, KA; Dahl, A; Aguilar-Salinas, CA; Atzmon, G; Barajas-Olmos, F; Barzilai, N; et al; [incl. Kuusisto, J; Laakso, M]. 2021. Nature communications. 12: 3505

Machine Learning Reveals Time-Varying Microbial Predictors with Complex Effects on Glucose Regulation

Aasmets, Oliver; Lüll, Kreete; Lang, Jennifer M; Pan, Calvin; Kuusisto, Johanna; Fischer, Krista; Laakso, Markku; Lusis, Aldons J; Org, Elin. 2021. MSystems. 6: e-01191-20

Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids

Fagerlund, Ilkka; Dougalis, Antonios; Shakirzyanova, Anastasia; Gómez-Budia, Mireia; Pelkonen, Anssi; Konttinen, Henna; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Koskuvi, Marja; Kuusisto, Johanna; Hernández, Damián; Pebay, Alice; Koistinaho, Jari; Rauramaa, Tuomas; Lehtonen, ¦árka; Korhonen, Paula; Malm, Tarja. 2021. Cells. 2022; 11: 124

Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences

Ganel, Liron; Chen, Lei; Christ, Ryan; Vangipurapu, Jagadish; Young, Erica; Das, Indraniel; Kanchi, Krishna; Larson, David; Regier, Allison; Abel, Haley; Kang, Chul Joo; Scott, Alexandra; Havulinna, Aki; Chiang, Charleston WK; Service, Susan; Freimer, Nelson; Palotie, Aarno; Ripatti, Samuli; Kuusisto, Johanna; Boehnke, Michael; Laakso, Markku; Locke, Adam; Stitziel, Nathan O; Hall, Ira M. 2021. Human genomics. 15: 1-17

Nationwide prevalence and characteristics of transthyretin amyloid cardiomyopathy in Sweden

Lauppe, Rosa Elisabeth; Liseth Hansen, Johan; Gerdesköld, Christian; Rozenbaum, Mark H; Strand, Anne Mette; Vakevainen, Merja; Kuusisto, Johanna; Gude, Einar; Gustafsson, Finn; Smith, J Gustav. 2021. Open heart. 8: e001755

Rare coding variants in 35 genes associate with circulating lipid levels - A multi-ancestry analysis of 170,000 exomes

Hindy, George; Dornbos, Peter; Chaffin, Mark D.; Liu, Dajiang J.; Wang, Minxian; Selvaraj, Margaret Sunitha; Zhang, David; Park, Joseph; Aguilar-Salinas, Carlos A.; Antonacci-Fulton, Lucinda; Ardissino, Diego; Arnett, Donna K.; Aslibekyan, Stella; Atzmon, Gil; Ballantyne, Christie M.; Barajas-Olmos, Francisco; Barzilai, Nir; Becker, Lewis C.; Bielak, Lawrence F.; Bis, Joshua C. et al [incl. Kuusisto, Johanna; Laakso, Markku]. 2021. American journal of human genetics. 2022; 109: 81 - 96

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Mägi, Reedik; Hottenga, Jouke- Jan; Grallert, Harald; Perry, John R. B.; Bouatia-Naji, Nabila; Marullo, Letizia; Rybin, Denis; Jansen, Rick; Min, Josine L.; Dimas, Antigone S.; Ulrich, Anna; Zudina, Liudmila; Gådin, Jesper R.; Jiang, Longda; Faggian, Alessia; Bonnefond, Amélie; Fadista, Joao; Stathopoulou, Maria G.; Isaacs, Aaron; Willems, Sara M et al. [incl. Kuusisto, Johanna; Laakso, Markku; Lakka, Timo, Uusitupa, Matti]. 2021. Nature communications. 12: 24

The association of nine amino acids with cardiovascular events in Finnish men in a 12-year follow-up study

Jauhiainen, Raimo; Vangipurapu, Jagadish; Laakso, Annamaria; Kuulasmaa, Teemu; Kuusisto, Johanna; Laakso, Markku. 2021. Journal of clinical endocrinology and metabolism. 106: 3448-3454

The power of genetic diversity in genome-wide association studies of lipids

Graham, Sarah E; Clarke, Shoa L; Wu, Kuan-Han H; Kanoni, Stavroula; Zajac, Greg JM; Ramdas, Shweta; Surakka, Ida; Ntalla, Ioanna; Vedantam, Sailaja; Winkler, Thomas W; Locke, Adam E; Marouli, Eirini; Hwang, Mi Yeong; Han, Sohee; Narita, Akira; Choudhury, Ananyo; Bentley, Amy R; Ekoru, Kenneth; Verma, Anurag; Trivedi, Bhavi [incl. Kuusisto, Johanna; Laakso, Markku]. 2021. Nature. 600: 675-679

The trans-ancestral genomic architecture of glycemic traits

Chen, J; Spracklen, CN; Marenne, G; Varshney, A; Corbin, LJ; Luan, J; Willems, SM; Wu, Y; Zhang, X; Horikoshi, M; Boutin, TS; Mägi, R; Waage, J; Li-Gao, R; Chan, KHK; Yao, J; Anasanti, MD; Chu, AY; Claringbould, A; Heikkinen, J; et al. [incl. Kuulasmaa, T; Kuusisto, J; Laakso, M; Lakka, T; Uusitupa, M; Vangipurapu, J]. 2021. Nature genetics. 53: 840-860

Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences

Spracklen, Cassandra N; Iyengar, Apoorva K; Vadlamudi, Swarooparani; Raulerson, Chelsea K; Jackson, Anne U; Brotman, Sarah M; Wu, Ying; Cannon, Maren E; Davis, James P; Crain, Aaron T; Currin, Kevin W; Perrin, Hannah J; Narisu, Narisu; Stringham, Heather M; Fuchsberger, Christian; Locke, Adam E; et al. [incl. Laakso, Markku]. 2020. PLoS genetics. 16: e1009019

Cardiomyopathy associated with the Ala143Thr variant of the α-galactosidase A gene

Valtola, K; Nino-Quintero, J; Hedman, M; Lottonen-Raikaslehto, L; Laitinen, T; Maria, M; Kantola, I; Naukkarinen, A; Laakso, M; Kuusisto, J. 2020. Heart. 106: 609-615

Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer's disease

Rolova, Taisia; Wu, Ying-Chieh; Koskuvi, Marja; Voutilainen, Jenni; Sonninen, Tuuli-Maria; Kuusisto, Johanna; Laakso, Markku; Hämäläinen, Riikka H; Koistinaho, Jari; Lehtonen, Sárka. 2020. Stem cell research. 48: 101968

Genetics of hypertrophic cardiomyopathy: what is the next step?

Kuusisto, Johanna. 2020. Heart. 106: 1291-1292

Novel biomarkers associated with incident heart failure in 10 106 Finnish men

Jauhiainen, Raimo; Jauhiainen, Matti; Vangipurapu, Jagadish; Kuulasmaa, Teemu; Ala-Korpela, Mika; Laakso, Markku; Kuusisto, Johann. 2020. ESC heart failure. 2021; 8: 605-614

Rotation and torsion of the left ventricle with cardiovascular magnetic resonance tagging: comparison of two analysis methods

Lehmonen, Lauri; Jalanko, Mikko; Tarkiainen, Mika; Kaasalainen, Touko; Kuusisto, Johanna; Lauerma, Kirsi; Savolainen, Sauli. 2020. Bmc medical imaging. 20: 73

A catalog of genetic loci associated with kidney function from analyses of a million individuals

Wuttke; M; Li, Y; Li, M; Sieber, KB; Feitosa, MF; Gorski, M; Tin, A; Wang, L; Chu, AY; Hoppmann, A; Kirsten, H; Giri, A; Chai, JF; Sveinbjornsson, G; Tayo, BO; Nutile, T; Fuchsberger, C; Marten, J; et al. (incl. Kuusisto, J; Laakso, M). 2019. Nature genetics. 51: 957-972

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

Sung, Yun Ju; de Las Fuentes, Lisa; Winkler, Thomas W; Chasman, Daniel I; Bentley, Amy R; Kraja, Aldi T; Ntalla, Ioanna; Warren, Helen R; Guo, Xiuqing; Schwander, Karen; Manning, Alisa K; Brown, Michael R; Aschard, Hugues; Feitosa, Mary F; Franceschini, Nora; Lu, Yingchang; et al. (incl. Heikkinen, Sami; Kuusisto, Johanna; Laakso, Markku; Stancáková, Alena; Lakka, Timo A). 2019. Human molecular genetics. 28: 2615-2633

Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits

Raulerson, CK; Ko, A; Kidd, JC; Currin, KW; Brotman, SM; Cannon, ME; Wu, Y; Spracklen, CN; Jackson, AU; Stringham, HM; Welch, RP; Fuchsberger, C; Locke, AE; Narisu, N; Lusis, AJ; Civelek, M; Furey, TS; Kuusisto, J; Collins, FS; Boehnke, M; et al. [incl. Laakso, M]. 2019. American journal of human genetics. 105: 773-787

Associations of autozygosity with a broad range of human phenotypes

Clark, DW; Okada, Y; Moore, KHS; Mason, D; Pirastu, N; Gandin, I; Mattsson, H; Barnes, CLK; Lin, K; Zhao, JH; Deelen, P; Rohde, R; Schurmann, C; Guo, X; Giulianini, F; Zhang, W; Medina-Gomez, C; Karlsson, R; Bao, Y; Bartz, TM; et al. [incl. Kuusisto, J; Laakso, M; Vangipurapu, J; Yaluri, A]. 2019. Nature communications. 10: 4957

CMR derived left ventricular septal convexity in carriers of the hypertrophic cardiomyopathy-causing MYBPC3-Q1061X mutation

Tarkiainen, M; Sipola, P; Jalanko, M; Heliö, T; Jääskeläinen, P; Kivelä, K; Laine, M; Lauerma, K; Kuusisto, J. 2019. Scientific reports. 9: 5960

Circulating RNAs as predictive markers for the progression of type 2 diabetes

Ghai, V; Baxter, D; Wu, X; Kim, TK; Kuusisto, J; Laakso, M; Connolly, T; Li, Y; Andrade-Gordon, P; Wang, K. 2019. Journal of cellular and molecular medicine. 23: 2753-2768

Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution

Wu, Y; Broadaway, KA; Raulerson, CK; Scott, LJ; Pan, C; Ko, A; He, A; Tilford, C; Fuchsberger, C; Locke, AE; Stringham, HM; Jackson, AU; Narisu, N; Kuusisto, J; Pajukanta, P; Collins, FS; Boehnke, M; Laakso, M; Lusis, AJ; Civelek, M; et al.. 2019. Human molecular genetics. 28: 4161-4172

Disentangling the genetics of lean mass

Karasik, D; Zillikens, MC; Hsu, YH; Aghdassi, A; Akesson, K; Amin, N; Barroso, I; Bennett, DA; Bertram, L; Bochud, M; Borecki, IB; Broer, L; Buchman, AS; Byberg, L; Campbell, H; Campos-Obando, N; Cauley, JA; Cawthon, PM; Chambers, JC; Chen, Z; et al. (incl. Kuulasmaa, Teemu; Kuusisto, Johanna; Laakso, Markku). 2019. American journal of clinical nutrition. 109: 276-287

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

Flannick, J; Mercader, JM; Fuchsberger, C; Udler, MS; Mahajan, A; Wessel, J; Teslovich, TM; Caulkins, L; Koesterer, R; Barajas-Olmos, F; Blackwell, TW; Boerwinkle, E; Brody, JA; Centeno-Cruz, F; Chen, L; Chen, S; Contreras-Cubas, C; Córdova, E; et al. (incl. Kuusisto, J; Laakso, M). 2019. Nature. 570: 71-76

Fabry-kardiomyopatia

Kantola, Ilkka; Kuusisto, Johanna. 2019. Sydänääni. 30: 161-169

Genetic basis and outcome in a nationwide study of Finnish patients with hypertrophic cardiomyopathy

Jääskeläinen, P; Vangipurapu, J; Raivo, J; Kuulasmaa, T; Heliö, T; Aalto-Setälä, K; Kaartinen, M; Ilveskoski, E; Vanninen, S; Hämäläinen, L; Melin, J; Kokkonen, J; Nieminen, MS; FinHCM Study Group; Laakso, M; Kuusisto, J. 2019. ESC heart failure. 6: 436-445

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

de Vries, PS; Brown, MR; Bentley, AR; Sung, YJ; Winkler, TW; Ntalla, I; Schwander, K; Kraja, AT; Guo, X; Franceschini, N; Cheng, CY; Sim, X; Vojinovic, D; Huffman, JE; Musani, SK; Li, C; Feitosa, MF; Richard, MA; Noordam, R; Aschard, H; et al. (Incl. Kuusisto, Johanna; Laakso, Markku; Lakka, Timo; Heikkinen, Sami). 2019. American journal of epidemiology. 188: 1033-1054

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Bentley, AR; Sung, YJ; Brown, MR; Winkler, TW; Kraja, AT; Ntalla, I; Schwander, K; Chasman, DI; Lim, E; Deng, X; Guo, X; Liu, J; Lu, Y; Cheng, CY; Sim, X; Vojinovic, D; Lakka, TA; Heikkinen, S; Kuusisto, J; Laakso, M; et al. (incl. Laakso, Markku; Heikkinen, Sami; Kuusisto, Johanna; Lakka, Timo; Rauramaa, Rainer). 2019. Nature genetics. 51: 636-648

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Kilpeläinen, TO; Bentley, AR; Noordam, R; Sung, YJ; Schwander, K; Winkler, TW; Jakupovic, H; Chasman, DI; Manning, A; Ntalla, I; Aschard, H; Brown, MR; de Las Fuentes, L; Franceschini, N; Guo, X; Vojinovic, D; Aslibekyan, S; Feitosa, MF; Kho, M; Musani, SK; et al. [Incl. Lakka, Timo; Heikkinen, Sami; Kuusisto, Johanna; Laakso, Markku]. 2019. Nature communications. 10: 376

New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

Evangelou E; Gao, H; Chu, C; Ntritsos, G; Blakeley, P; Butts, AR; Pazoki, R; Suzuki, H; Koskeridis, F; Yiorkas, AM; Karaman, I; Elliott, J; Luo, Q; Aeschbacher, S; Bartz, TM; Baumeister, SE; Braund, PS; Brown, MR; Brody, JA; Clarke TK; et al. (Incl. Yaluri, A; Kuusisto, J; Laakso, M; Vangipurapu, J). 2019. Nature human behaviour. 3: 950-961

Nine Amino Acids are Associated with Decreased Insulin Secretion and Elevated Glucose Levels in a 4.6-Year Follow-Up Study of 5,181 Finnish Men

Vangipurapu, J; Stancáková, A; Smith, U; Kuusisto, J; Laakso, M. 2019. Diabetes. 68: 1353-1358

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

Justice, AE; Karaderi, T; Highland, HM; Young, KL; Graff, M; Lu, Y; Turcot, V; Auer, PL; Fine, RS; Guo, X; Schurmann, C; Lempradl, A; Marouli, E; Mahajan, A; Winkler, TW; Locke, AE; Medina-Gomez, C; Esko, T; Vedantam, S; Giri, A; Lo, KS; et al. (Incl. Kuusisto, Johanna; Laakso, Markku; Lakko, Timo; Uusitupa, Matti; Vanhala, Mauno). 2019. Nature genetics. 51: 452-469

A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression

Kycia, I; Wolford, BN; Huyghe, JR; Fuchsberger, C; Vadlamudi, S; Kursawe, R; Welch, RP; Albanus, RD; Uyar, A; Khetan, S; Lawlor, N; Bolisetty, M; Mathur, A; Kuusisto, J; Laakso, M; Ucar, D; Mohlke, KL; Boehnke, M; Collins, FS; Parker, SCJ; et al.. 2018. American journal of human genetics. 102: 620-635

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

Sung, YJ; Winkler, TW; de Las Fuentes, L; Bentley, AR; Brown, MR; Kraja, AT; Schwander, K; Ntalla, I; Guo, X; Franceschini, N; Lu, Y; Cheng, CY; Sim, X; Vojinovic, D; Marten, J; Musani, SK; Li, C; Feitosa, MF; Kilpeläinen, TO; Richard, MA et al. (incl. Yaluri, Alena; Heikkinen, Sami; Kuusisto, Johanna; Laakso, Markku). 2018. American journal of human genetics. 102: 375-400

A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study

Latva-Rasku, A; Honka, MJ; Stancáková, A; Koistinen, HA; Kuusisto, J; Guan, L; Manning, AK; Stringham, H; Gloyn, AL; Lindgren, CM; T2D-GENES Consortium; Collins, FS; Mohlke, KL; Scott, LJ; Karjalainen, T; Nummenmaa, L; Boehnke, M; Nuutila, P; Laakso, M. 2018. Diabetes. 67: 334-342

Akuuttia sisämedisiinaa tarvitaan

Kuusisto, Johanna; Kaukinen, Katri; Kaaja, Risto. 2018. Lääkärilehti. 73: 1562

Decreased plasma C-reactive protein levels in APOE E 4 allele carriers

Martiskainen, Henna; Takalo, Mari; Solomon, Alina; Stancáková, Alena; Marttinen, Mikael; Natunen, Teemu; Haapasalo, Annakaisa; Herukka, Sanna-Kaisa; Kuusisto, Johanna; Soininen, Hilkka; Kivipelto, Miia; Laakso, Markku; Hiltunen, Mikko. 2018. Annals of clinical and translational neurology. 5: 1229-1240

Epigenome-wide association in adipose tissue from the METSIM cohort

Orozco, Luz D; Farrell, Colin; Hale, Christopher; Rubbi, Liudmilla; Rinaldi, Arturo; Civelek, Mete; Pan, Calvin; Lam, Larry; Montoya, Dennis; Edillor, Chantle; Seldin, Marcus; Boehnke, Michael; Mohlke, Karen L; Jacobsen, Steve; Kuusisto, Johanna; Laakso, Markku; Lusis, Aldons J; Pellegrini, Matteo. 2018. Human molecular genetics. 27: 1830-1846

Fibrosis and wall thickness affect ventricular repolarization dynamics in hypertrophic cardiomyopathy

Jalanko, M; Väänänen, H; Tarkiainen, M; Sipola, P; Jääskeläinen, P; Lauerma, K; Laitinen, T; Laitinen, T; Laine, M; Heliö, T; Kuusisto, J; Viitasalo, M. 2018. Annals of noninvasive electrocardiology. 23: e12582

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Mahajan, A; Taliun, D; Thurner, M; Robertson, NR; Torres, JM; Rayner, NW; Payne, AJ; Steinthorsdottir, V; Scott, RA; Grarup, N; Cook, JP; Schmidt, EM; Wuttke, M; Sarnowski, C; Mägi, R; Nano, J; Gieger, C; Trompet, S; Lecoeur, C; Preuss, MH; et al (Incl. Laakso, Markku; Kuusisto, Johanna; Yaluri, Alena). 2018. Nature genetics. 50: 1505-1512

Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia

López Rodríguez, Maykel; Fernandes Silva, Lilian; Vangipurapu, Jagadish; Modi, Shalem; Kuusisto, Johanna; Kaikkonen, Minna U; Laakso, Markku. 2018. Scientific reports. 8: 15989

Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease

Lehtonen, S; Höytyläinen, I; Voutilainen, J; Sonninen, T-M; Kuusisto, J; Laakso, M; Hämäläinen, RH; Oksanen, M; Koistinaho, J. 2018. Stem cell research. 30: 96-99

Genetiikka

Heliö, Tiina; Kuusisto, Johanna. 2018. Sydänääni. 29: 199-202

Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study

Teslovich, Tanya M; Kim, Daniel Seung; Yin, Xianyong; Stancakova, Alena; Jackson, Anne U; Wielscher, Matthias; Naj, Adam; Perry, John R B; Huyghe, Jeroen R; Stringham, Heather M; Davis, James P; Raulerson, Chelsea K; Welch, Ryan P; Fuchsberger, Christian; Locke, Adam E; Sim, Xueling; Chines, Peter S; Narisu, Narisu; Kangas, Antti J; Soininen, Pasi; et al (incl. Yaluri, Alena; Ala-Korpela, Mika; Kuusisto, Johanna; Laakso, Markku; Soininen, Pasi). 2018. Human molecular genetics. 27: 1664-1674

Novel electrocardiographic features in carriers of hypertrophic cardiomyopathy causing sarcomeric mutations

Jalanko, Mikko; Heliö, Tiina; Mustonen, Pirjo; Kokkonen, Jorma; Huhtala, Heini; Laine, Mika; Jääskeläinen, Pertti; Tarkiainen, Mika; Lauerma, Kirsi; Sipola, Petri; Laakso, Markku; Kuusisto, Johanna; Nikus, Kjell. 2018. Journal of electrocardiology. 51: 983-989

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

Feitosa, MF; Kraja, AT; Chasman, DI; Sung, YJ; Winkler, TW; Ntalla, I; Guo, X; Franceschini, N; Cheng, CY; Sim, X; Vojinovic, D; Marten, J; Musani, SK; Li, C; Bentley, AR; Brown, MR; Schwander, K; Richard, MA; Noordam, R; Aschard, H; et al. (incl. Laakso, Markku; Heikkinen, Sami; Kuusisto, Johanna; Lakka, Timo; Yaluri, Alena). 2018. PLoS ONE. 13: e0198166

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

Mahajan, A; Wessel, J; Willems, SM; Zhao, W; Robertson, NR; Chu, AY; Gan, W; Kitajima, H; Taliun, D; Rayner, NW; Guo, X; Lu, Y; Li, M; Jensen, RA; Hu, Y; Huo, S; Lohman, KK; Zhang, W; Cook, JP; Prins, BP; et al. (Incl. Laakso, Markku; Kuusisto, Johanna; Yaluri, Alena). 2018. Nature genetics. 50: 559-571

Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling

Koivumäki, Jussi T; Naumenko, Nikolay; Tuomainen, Tomi; Takalo, Jouni; Oksanen, Minna; Puttonen, Katja A; Lehtonen, Sarka; Kuusisto, Johanna; Laakso, Markku; Koistinaho, Jari; Tavi, Pasi. 2018. Frontiers in physiology. 9: 80

Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans

Lin, LY; Chun-Chang, S; O'Hearn, J; Hui, ST; Seldin, M; Gupta, P; Bondar, G; Deng, M; Jauhiainen, R; Kuusisto, J; Laakso, M; Sinsheimer, JS; Deb, A; Rau, C; Ren, S; Wang, Y; Lusis, AJ; Wang, JJ; Huertas-Vazquez, A. 2018. G3: genes, genomes, genetics. 8: 3499-3506

A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the Adcy5 Locus

Roman TS, Cannon ME, Vadlamudi S, Buchkovich ML, Wolford BN, Welch RP, Morken MA, Kwon GJ, Varshney A, Kursawe R, Wu Y, Jackson AU, Erdos MR, Kuusisto J, Laakso M, Scott LJ, Boehnke M, Collins FS, Parker SCJ, Stitzel ML, Mohlke KL. 2017. Diabetes. 66: 2521-2530

Clinical disease presentation and ECG characteristics of LMNA mutation carriers

Ollila L, Nikus K, Holmström M, Jalanko M, Jurkko R, Kaartinen M, Koskenvuo J, Kuusisto J, Kärkkäinen S, Palojoki E, Reissell E, Piirilä P, Heliö T. 2017. Open heart. 4: e000474

Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study

Davis JP, Huyghe JR, Locke AE, Jackson AU, Sim X, Stringham HM, Teslovich TM, Welch RP, Fuchsberger C, Narisu N, Chines PS, Kangas AJ, Soininen P, Ala-Korpela M, Kuusisto J, Collins FS, Laakso M, Boehnke M, Mohlke KL. 2017. PLoS genetics. 13: e1007079

Decreased plasma ß-amyloid in the Alzheimer's disease APP A673T variant carriers

Martiskainen H, Herukka SK, Stancáková A, Paananen J, Soininen H, Kuusisto J, Laakso M, Hiltunen M. 2017. Annals of neurology. 82: 128-132

Diabetes secondary to treatment with statins

Laakso Markku, Kuusisto Johanna. 2017. Current diabetes reports. 17: 1-9

Differential Associations of Inflammatory Markers With Insulin Sensitivity and Secretion: The Prospective METSIM Study

Fizelova M, Jauhiainen R, Kangas AJ, Soininen P, Ala-Korpela M, Kuusisto J, Laakso M, Stancáková A. 2017. Journal of clinical endocrinology and metabolism. 102: 3600-3609

Exome-wide association study of plasma lipids in >300,000 individuals

Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, Di Angelantonio E, Arveiler D, Assimes TL, Auer PL, Baber U, Ballantyne CM, Bang LE, Benn M, Bis JC et al.. 2017. Nature genetics. 49: 1758-1766

Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits

Civelek M, Wu Y, Pan C, Raulerson CK, Ko A, He A, Tilford C, Saleem NK, Stancáková A, Scott LJ, Fuchsberger C, Stringham HM, Jackson AU, Narisu N, Chines PS, Small KS, Kuusisto J, Parks BW, Pajukanta P, Kirchgessner T et al. 2017. American journal of human genetics. 100: 428-443

Genetic risk scores in the prediction of plasma glucose, impaired insulin secretion, insulin resistance and incident type 2 diabetes in the METSIM study

Stancakova Alena, Kuulasmaa Teemu, Kuusisto Johanna, Mohlke Karen L, Collinis Francis S, Boehnke Michael, Laakso Markku. 2017. Diabetologia. 60: 1722-1730

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Justice Anne E, Winkler Thomas W, Feitosa Mary F, Graff Misa, Fisher Virginia A, Young Kristin, Barata Llilda, Deng Xuan, Czajkowski Jacek, Hadley David, Ngwa Julius S, Ahluwalia Tarunveer S, Chu Audrey Y, Heard-Costa Nancy L, Lim Elise, Perez Jeremiah, Eicher John D, Kutalik Zoltan, Xue Luting, Mahajan Anubha et al.. 2017. Nature communications. 8: 14977

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, Xue L, Workalemahu T, Heard-Costa NL, den Hoed M, Ahluwalia TS, Qi Q, Ngwa JS, Renström F, Quaye L, Eicher JD et al.. 2017. PLoS genetics. 13: e1006528

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

Wheeler E, Leong A, Liu CT, Hivert MF, Strawbridge RJ, Podmore C, Li M, Yao J, Sim X, Hong J, Chu AY, Zhang W, Wang X, Chen P, Maruthur NM, Porneala BC, Sharp SJ, Jia Y, Kabagambe EK, Chang LC et al. (incl. Kuusisto J, Laakso M). 2017. PLoS ONE. 14: 1002383

Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study

de Mello VD, Paananen J, Lindstrom J, Lankinen MA, Shi L, Kuusisto J, Pihlajamaki J, Auriola S, Lehtonen M, Rolandsson O, Bergdahl IA, Nordin E, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Landberg R, Eriksson JG, Tuomilehto J, Hanhineva K, Uusitupa M. 2017. Scientific reports. 7: 46337

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Zillikens M Carola, Demissie Serkalem, Hsu Yi-Hsiang, Yerges-Armstrong Laura M, Chou Wen-Chi, Stolk Lisette, Livshits Gregory, Broer Linda, Johnson Toby, Koller Daniel L, Kutalik Zoltán, Luan Jian'an, Malkin Ida, Ried Janina S, Smith Albert V, Thorleifsson Gudmar, Vandenput Liesbeth, Zhao Jing Hua, Zhang Weihua, Aghdassi Ali et al. (incl. Cederberg Henna, Kuulasmaa Teemu, Kuusisto Johanna, Laakso Markku, Alena Stancáková). 2017. Nature communications. 8: 80

Lipidome as a predictive tool in progression to type 2 diabetes in Finnish men

Suvitaival T, Bondia-Pons I, Yetukuri L, Pöhö P, Nolan JJ, Hyötyläinen T, Kuusisto J, Ore¨ic M. 2017. Metabolism: clinical and experimental. 2018; 78: 1-12

Novel association of TM6SF2 rs58542926 genotype with increased serum tyrosine levels and decreased apoB-100 particles in Finns

Kim DS, Jackson AU, Li YK, Stringham HM, FinMetSeq Investigators, Kuusisto J, Kangas AJ, Soininen P, Ala-Korpela M, Burant CF, Salomaa V, Boehnke M, Laakso M, Speliotes EK. 2017. Journal of lipid research. 58: 1471-1481

Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease

Mardinoglu Adil, Stancáková Alena, Lotta Luca A, Kuusisto Johanna, Boren Jan, Blüher Matthias, Wareham Nicholas J, Ferrannini Ele, Groop Per Henrik, Laakso Markku, Langenberg Claudia, Smith Ulf. 2017. Cell metabolism. 26: 281-283

Predicting glycated hemoglobin levels in the non-diabetic general population: Development and validation of the DIRECT - DETECT prediction model - a DIRECT study

Rauh Simone P, Heymans Martijn W, Koopman Anitra DM, Nijpels Giel, Stehouwer Coen D, Thorand Barbara, Rathmann Wolfgang, Meisinger Christa, Peters Annette, de las Heras Gala Tonia, Glümer Charlotte, Pedersen Olut, Cederberg Henna, Kuusisto Johanna, Laakso Markku, Pearson Ewan R, Franks Paul W, Rutters Femke, Dekker Jacqueline M. 2017. PLoS ONE. 12: e0171816

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T et al. (incl. Laakso Markku, Lakka Timo, Uusitupa Matti). 2017. Nature genetics. 50; 2018: 26-41

Rare and low-frequency coding variants alter human adult height

Marouli Eirini, Graff Mariaelisa, Medina-Gomez Carolina, Sin Lo Ken, Wood Andrew R, Kjaer Troels R, Fine Rebecca S, Lu Yingchang, Schurmann Claudia, Highland Heather M, Rüeger Sina, Thorleifsson Gudmar, Justice Anne E, Lamparter David, Stirrups Kathleen E, Turcot Valérie, Young Kristin L, Winkler Thomas W, Esko Tõnu, Karaderi Tugce et al. (incl Kuusisto Johanna, Laakso Markku, Lakka Timo A). 2017. Nature. 542: 186-190

Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort

Org E, Blum Y, Kasela S, Mehrabian M, Kuusisto J, Kangas AJ, Soininen P, Wang ZN, Ala-Korpela M, Hazen SL, Laakso M, Lusis AJ. 2017. Genome biology. 18: 70

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Jason F, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Tajes JF et al. (incl. Kuulasmaa Teemu, Kuusisto Johanna, Laakso Markku). 2017. Scientific data. 4: 170179

The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases

Laakso Markku, Kuusisto Johanna, Stancakova Alena, Kuulasmaa Teemu, Pajukanta Päivi, Jake Lusis Aldons, Collins Francis S, Mohlke Karen, Boehnke Michael. 2017. Journal of lipid research. 58: 481-493

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology

Westwood S, Liu B, Baird AL, Anand S, Nevado-Holgado AJ, Newby D, Pikkarainen M, Hallikainen M, Kuusisto J, Streffer JR, Novak G, Blennow K, Andreasson U, Zetterberg H, Smith U, Laakso M, Soininen H, Lovestone S. 2017. Alzheimer's research and therapy. 9: 31

Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus

Cannon ME, Duan Q, Wu Y, Zeynalzadeh M, Xu Z, Kangas AJ, Soininen P, Ala-Korpela M, Civelek M, Lusis AJ, Kuusisto J, Collins FS, Boehnke M, Tang H, Laakso M, Li Y, Mohlke K. 2017. G3: genes, genomes, genetics. 7: 3217-3227

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

Scott Robert A, Freitag Daniel F, Li Li, Chu Audrey Y, Surendran Praveen, Young Robin, Grarup Niels, Stancáková Alena, Chen Yuning, Varga Tibor V, Yaghootkar Hanieh, Luan Jian'an, Zhao Jing Hua, Willems Sara M, Wessel Jennifer, Wang Shuai, Maruthur Nisa, Michailidou Kyriaki, Pirie Ailith, van der Lee Sven J et al. 2016. Science translational medicine. 8: pp. 341ra76

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G, Eklund N, Eriksson J, Esko T, Feitosa MF, Goel A, Gorski M, Hayward C, Heard-Costa NL, Jackson AU, Jokinen E, Kanoni S, Kristiansson K et al. 2016. Nature communications. 7: 13357

Cardiovascular magnetic resonance of mitral valve length in hypertrophic cardiomyopathy

Tarkiainen Mika, Sipola Petri, Jalanko Mikko, Heliö Tiina, Laine Mika, Järvinen Vesa, Häyrinen Kaisu, Lauerma Kirsi, Kuusisto Johanna. 2016. Journal of cardiovascular magnetic resonance. 18: 33

Current perspectives in hypertrophic cardiomyopathy with the focus on patients in the Finnish population: a review

Kuusisto Johanna, Sipola Petri, Jääskeläinen Pertti, Naukkarinen Anita. 2016. Annals of medicine. [Epub ahead of print 27 Jul 2016]: 1-13

Deleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy

West Gun, Gullmets Josef, Virtanen Laura, Li Song-Ping, Keinänen Anni, Shimi Takeshi, Mauermann Monika, Heliö Tiina, Kaartinen Maija, Ollila Laura, Kuusisto Johanna, Eriksson John E., Goldman Robert D., Herrmann Harald, Taimen Pekka. 2016. Journal of cell science. 129: 2732-2743

Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

Hinney A, Kesselmeier M, Jall S, Volckmar AL, Föcker M, Antel J, Heid IM, Winkler TW, Grant SF, Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H, Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM et al., GCAN, WTCCC3, EGG, GIANT, Price Foundation Collaborative Group, Children's Hospital of Philadelphia/Price Foundation. 2016. Molecular psychiatry. 2017; 22: 192-201

Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity

Walle Paula, Takkunen Markus, Männistö Ville, Vaittinen Maija, Lankinen Maria, Kärjä Vesa, Käkelä Pirjo, Ågren Jyrki, Tiainen Mika, Schwab Ursula, Kuusisto Johanna, Laakso Markku, Pihlajamäki Jussi. 2016. Metabolism: clinical and experimental. 65: 655-666

Finnish Diabetes Risk Score Is Associated with Impaired Insulin Secretion and Insulin Sensitivity, Drug-Treated Hypertension and Cardiovascular Disease: A Follow-Up Study of the METSIM Cohort

Fizelova Maria, Jauhiainen Raimo, Stancáková Alena, Kuusisto Johanna, Laakso Markku. 2016. PLoS ONE. 11: e0166584

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Pattaro Christian, Teumer Alexander, Gorski Mathias, Chu Audrey Y, Li Man, Mijatovic Vladan, Garnaas Maija, Tin Adrienne, Sorice Rossella, Li Yong, Taliun Daniel, Olden Matthias, Foster Meredith, Yang Qiong, Chen Ming-Huei, Pers Tune H, Johnson Andrew D, Ko Yi-An, Fuchsberger Christian, Tayo Bamiele et al.. 2016. Nature communications. 7: 10023

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci

Walford GA, Gustafsson S, Rybin D, Stancáková A, Chen H, Liu CT, Hong J, Jensen RA, Rice K, Morris AP, Mägi R, Tönjes A, Prokopenko I, Kleber ME, Delgado G, Silbernagel G, Jackson AU, Appel EV, Grarup N, Lewis JP et al.. 2016. Diabetes. 65: 3200-3211

Integrative approaches for large-scale transcriptome-wide association studies

Gusev Alexander, Ko Arthur, Shi Huwendo, Bhatia Gaurav, Chung Wonil, Penninx Brenda WJH, Jansen Rick, de Geus Eco JC, Boomsma Dorret I, Wright Fred A, Sullivan Patrick F, Nikkola Elina, Alvarez Marcus, Civelek Mete, Lusis Aldons J, Lehtimäki Terho, Raitoharju Emma, Kähönen Mika, Seppälä Ilkka, Raitakari Olli T et al. 2016. Nature genetics. 48: 245-252

Left ventricular mechanical dispersion is associated with nonsustained ventricular tachycardia in hypertrophic cardiomyopathy

Jalanko Mikko, Tarkiainen Mika, Sipola Petri, Jääskeläinen Pertti, Lauerma Kirsi, Laine Mika, Nieminen Markku S, Laakso Markku, Heliö Tiina, Kuusisto Johanna. 2016. Annals of medicine. : 2016 Jun 1:1-11. [Epub ahead of print]

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Lu Yingchang, Day Felix R, Gustafsson Stefan, Buchkovich Martin L, Na Jianbo, Bataille Veronique, Cousminer Diana L, Dastani Zari, Drong Alexander W, Esko Tönu, Evans David M, Falchi Mario, Feitosa Mary F, Ferreira Teresa, Hedman Åsa K, Haring Robin, Hysi Pirro G, Iles Mark M, Justice Anne E, Kanoni Stavroula et al. 2016. Nature communications. 7: 10495

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

Zanoni Paolo, Khetarpal Sumeet A, Larach Daniel B, Hancock-Cerutti William F, Millar John S, Cuchel Marina, DerOhannessian Stephanie, Kontush Anatol, Surendran Praveen, Saleheen Danish, Trompet Stella, Jukema J Wouter, De Craen Anton, Deloukas Panos, Sattar Naveed, Ford Ian, Packard Chris, Majumder Abdullah al Shafi , Alam Dewan S, Di Angelantonio Emanuele et al. 2016. Science. 351: 1166-1171

Regulation of alternative splicing in human obesity loci

Kaminska Dorota, Käkelä Pirjo, Nikkola Elina, Venesmaa Sari, Ilves Imre, Herzig Karl-Heinz, Kolehmainen Marjukka, Karhunen Leila, Kuusisto Johanna, Gylling Helena, Pajukanta Päivi, Laakso Markku, Pihlajamäki Jussi. 2016. Obesity. 24: 2033-2037

Short adult stature predicts impaired beta-cell function, insulin resistance, glycemia and type 2 diabetes in Finnish men

Vangipurapu Jagadish, Stancakova Alena, Jauhiainen Raimo, Kuusisto Johanna, Laakso Markku. 2016. Journal of clinical endocrinology and metabolism. 2017: 102: 443-450

The genetic architecture of type 2 diabetes

Fuchsberger Christian, Flannick Jason, Teslovich Tanya M, Mahajan Anubha, Agarwala Vineeta, Gaulton Kyle J, Ma Clement, Fontanillas Pierre, Moutsianas Loukas, McCarthy Davis J, Rivas Manuel A, Perry John RB, Sim Xueling, Blackwell Thomas W, Robertson Neil R, Rayner N William, Cingolani Pablo, Locke Adam E, Tajes Juan Fernandes, Highland Heather M, (incl Kuulasmaa Teemu). 2016. Nature. 536: 41-47

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Ehret GB, Ferreira T, Chasman DI, Jackson AU, Schmidt EM, Johnson T, Thorleifsson G, Luan J, Donnelly LA, Kanoni S, Petersen AK, Pihur V, Strawbridge RJ, Shungin D, Hughes MF, Meirelles O, Kaakinen M, Bouatia-Naji N, Kristiansson K, Shah S et al.. 2016. Nature genetics. 48: 1171-1184

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK, Grarup N, Sim X, Barnes DR, Witkowska K, Staley JR, Tragante V, Tukiainen T, Yaghootkar H, Masca N, Freitag DF, Ferreira T, Giannakopoulou O, Tinker A, Harakalova M et al. 2016. Nature genetics. 48: 1151-1161

Associations of multiple lipoprotein and apolipoprotein measures with worsening of glycemia and incident type 2 diabetes in 6607 non-diabetic Finnish men

Fizelova Maria, Miilunpohja Manna, Kangas Antti J, Soininen Pasi, Kuusisto Johanna, Ala-Korpela Mika, Laakso Markku, Stancáková Alena. 2015. Atherosclerosis. 240: 272-277

Biological interpretation of genome-wide association studies using predicted gene functions

Pers Tune H, Karjalainen Juha M, Chan Yingleong, Westra Harm-Jan, Wood Andrew R, Yang Jian, Lui Julian C, Vedantam Sailaja, Gustafsson Stefan, Esko Tonu, Frayling Tim, Speliotes Elizabeth K, Genetic Investigation of ANthropometric Traits (GIANT) Consortium (incl. Johanna Kuusisto, Markku Laakso, Timo Lakka, Matti Uusitupa), Boehnke Michael, Raychaudhuri Soumya, Fehrmann Rudolf SN, Hirschhorn Joel N, Franke Lude. 2015. Nature communications. 6: 5890

Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 finnish men

Vangipurapu Jagadish, Stancáková Alena, Kuulasmaa Teemu, Kuusisto Johanna, Laakso Markku. 2015. PLoS ONE. 10: e0124028

Dietary polyunsaturated fatty acids and the Pro12Ala polymorphisms of PPARG regulate serum lipids through divergent pathways: a randomized crossover clinical trial

Pihlajamäki Jussi, Schwab Ursula, Kaminska Dorota, Ågren Jyrki, Kuusisto Johanna, Kolehmainen Marjukka, Paananen Jussi, Laakso Markku, Uusitupa Matti. 2015. Genes and nutrition. 10: 43

Directional dominance on stature and cognition in diverse human populations

Joshi Peter K, Esko Tonu, Mattsson Hannele, Eklund Niina, Gandin Ilaria, Nutile Teresa, Jackson Anne U, Schurmann Claudia, Smith Albert V, Zhang Weihua, Okada Yukinori, Stancáková Alena, Faul Jessica D, Zhao Wei, Bartz Traci M, Pina Concas Maria, Franceschini Nora, Enroth Stefan, Vitart Veronique, Trompet Stella et al (incl. Kuusisto Johanna, Laakso Markku). 2015. Nature. 523: 459-462

Evaluation of the efficacy and safety of three dosing regimens of agalsidase alfa enzyme replacement therapy in adults with Fabry disease

Golán L, Goker-Alpan O, Holida M, Kantola I, Klopotowski M, Kuusisto J, Linhart A, Musial J, Nicholls K, Gonzalez-Rodriguez D, Sharma R, Vujkovac B, Chang P, Wijatyk A. 2015. Drug design development and therapy. 2015: 3435-3444

Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men

Takkunen Markus J, de Mello Vanessa D, Schwab Ursula S, Kuusisto Johanna, Vaittinen Maija, Ågren Jyrki J, Laakso Markku, Pihlajamäki Jussi, Uusitupa MI. 2015. Molecular nutrition and food research. 2016; 60: 381-389

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, William Rayner N, Robertson N, Scott RA, Prokopenko I, Scott LJ, Green T, Sparso T, Thuillier D, Yengo L, Grallert H, Wahl S, Frånberg M et al.. 2015. Nature genetics. 47: 1415-1425

Genetic studies of body mass index yield new insights for obesity biology

Locke Adam E, Kahali Bratati, Berndt Sonja I, Justice Anne E, Pers Tune H, Day Felix R, Powell Corey, Vedantam Sailaja, Buchkovich Martin L, Yang Jian, Croteau-Chonka Damien C, Esko Tonu, Fall Tove, Ferreira Teresa, Gustafsson Stefan, Kutalik Zoltán, Luan Jian'an, Mägi Reedik, Randall Joshua C, Winkler Thomas W et al. 2015. Nature. 518: 197-206

Genetically determined height and coronary artery disease

Christopher P. Nelson, Stephen E. Hamby, Danish Saleheen, Jenna C. Hopewell, Lingyao Zeng, Themistocles L. Assimes, Stavroula Kanoni, Christina Willenborg, Stephen Burgess, Phillipe Amouyel, Sonia Anand, Stefan Blankenberg, Bernhard O. Boehm, Robert J. Clarke, Rory Collins, George Dedoussis, Martin Farrall, Paul W. Franks, Leif Groop, Alistair S. Hall et al. for the CARDIoGRAM+C4D Consortium (inicl. Kuusisto, Laakso). 2015. The new england journal of medicine. 372: 1608-1618

Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB

Berglund Lisa M, Lyssenko Valeriya, Ladenvall Claes, Kotova Olga, Edsfeldt Andreas, Pilgaard Kasper, Alkayyali Sami, Brøns Charlotte, Forsblom Carol, Jonsson Anna, Zetterqvist Anna V, Nitulescu Mihaela, McDavitt Christian Ruiz, Dunér Pontus, Stancáková Alena, Kuusisto Johanna, Ahlqvist Emma, Lajer Maria, Tarnow Lise, Madsbad Sten et al. 2015. Diabetes. (2016) 65: 239-254

Glycated hemoglobin levels are mostly dependent on nonglycemic parameters in 9398 Finnish men without diabetes

Fizelova Maria, Stancáková Alena, Lorenzo Carlos, Haffner Steven M, Cederberg Henna, Kuusisto Johanna, Laakso Markku. 2015. Journal of clinical endocrinology and metabolism. 100: 1989-1996

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus

Mahajan Anubha, Sim Xueling, Ng Hui Jin, Manning Alisa, Rivas Manuel A, Highland Heather M, Locke Adam E, Grarup Niels, Im Hae Kyung, Cingolani Pablo, Flannick Jason, Fontanillas Pierre, Fuchsberger Christian, Gaulton Kyle J, Teslovich Tanya M, Rayner N William, Robertson Neil R, Beer Nicola L, Rundle Jana K, Bork-Jensen Jette et al. On Behalf of the T2D-GENES consortium and GoT2D consortium. 2015. PLoS genetics. 11: e1004876

Increased Visceral Adipose Tissue as a Potential Risk Factor in Patients with Embolic Stroke of Undetermined Source (ESUS)

Muuronen Antti T, Taina Mikko, Hedman Marja, Marttila Jarkko, Kuusisto Johanna, Onatsu Juha, Vanninen Ritva, Jäkälä Pekka, Sipola Petri, Mustonen Pirjo. 2015. PLoS ONE. 10: e0120598

Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort

Cederberg Henna, Stancáková Alena, Yaluri Nagendra, Modi Shalem, Kuusisto Johanna, Laakso Markku. 2015. Diabetologia. 58: 1109-1117

Increased ventilatory response to exercise in symptomatic and asymptomatic LMNA mutation carriers: a follow-up study

Ollila L, Heliö T, Sovijärvi A, Jalanko M, Kaartinen M, Kuusisto J, Kärkkäinen S, Jurkko R, Reissell E, Palojoki E, Piirilä P. 2015. Clinical physiology and functional imaging. 2017; 37: 8-16

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

Wessel Jennifer, Chu Audrey Y, Willems Sara M, Wang Shuai, Yaghootkar Hanieh, Brody Jennifer A, Dauriz Marco, Hivert Marie-France, Raghavan Sridharan, Lipovich Leonard, Hidalgo Bertha, Fox Keolu, Huffman Jennifer E, An Ping, Lu Yingchang, Rasmussen-Torvik Laura J, Grarup Niels, Ehm Margaret G, Li Li, Baldridge Abigail S et al. 2015. Nature communications. 6: 5897

Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol

Roman Tamara S, Marvelle Amanda F, Fogarty Marie P, Vadlamudi Swarooparani, Gonzalez Arlene J, Buchkovich Martin L, Huyghe Jeroen R, Fuchsberger Christian, Jackson Anne U, Wu Ying, Civelek Mete, Lusis Aldons J, Gaulton Kyle J, Sethupathy Praveen, Kangas Antti J, Soininen Pasi, Ala-Korpela Mika, Kuusisto Johanna, Collins Francis S, Laakso Markku, Boehnke Michael, Mohlke Karen L.. 2015. American journal of human genetics. 97: 801-815

New genetic loci link adipose and insulin biology to body fat distribution

Shungin Dmitry, Winkler Thomas W, Croteau-Chonka Damien C, Ferreira Teresa, Locke Adam E, Mägi Reedik, Strawbridge Rona J, Pers Tune H, Fischer Krista, Justice Anne E, Workalemahu Tsegaselassie, Wu Joseph MW, Buchkovich Martin L, Heard-Costa Nancy L, Roman Tamara S, Drong Alexander W, Song Ci, Gustafsson Stefan, Day Felix R, Esko Tonu et al. 2015. Nature. 518: 187-196

Plasma fatty acids as predictors of glycaemia and type 2 diabetes

Lankinen Maria A, Stancáková Alena, Uusitupa Matti, Ågren Jyrki, Pihlajamäki Jussi, Kuusisto Johanna, Schwab Ursula, Laakso Markku. 2015. Diabetologia. 58: 2533-2544

Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells

Yaluri Nagendra, Modi Shalem, López Rodríguez Maykel, Stancáková Alena, Kuusisto Johanna, Kokkola Tarja, Laakso Markku. 2015. PLoS ONE. 10: e0142902

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Winkler Thomas W, Justice Anne E, Graff Mariaelisa, Barata Llilda, Feitosa Mary F, Chu Su, Czajkowski Jacek, Esko Tõnu, Fall Tove, Kilpeläinen Tuomas O, Lu Yingchang, Mägi Reedik, Mihailov Evelin, Pers Tune H, Rüeger Sina, Teumer Alexander, Ehret Georg B, Ferreira Teresa, Heard-Costa Nancy L, Karjalainen Juha et al. 2015. PLoS genetics. 11: e1005378

The Metabolome in Finnish Carriers of the MYBPC3-Q1061X Mutation for Hypertrophic Cardiomyopathy

Jorgenrud Benedicte, Jalanko Mikko, Heliö Tiina, Jääskeläinen Pertti, Laine Mika, Hilvo Mika, Nieminen Markku S., Laakso Markku, Hyötyläinen Tuulia, Oresic Matej, Kuusisto Johanna. 2015. PLoS ONE. 10: e0134184

A Central Role for GRB10 in Regulation of Islet Function in Man

Prokopenko Inga, Poon Wenny, Mägi Reedik, Prasad BR, Salehi S Albert, Almgren Peter, Osmark Peter, Bouatia-Naji Nabila, Wierup Nils, Fall Tove, Stancáková Alena, Barker Adam, Lagou Vasiliki, Osmond Clive, Xie Weijia, Lahti Jari, Jackson Anne U, Cheng Yu-Ching, Liu Jie, O'Connell Jeffrey R et al. (including Kuusisto Johanna, Laakso Markku, Lakka Timo). 2014. PLoS genetics. 10: e1004235

A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell

Kulzer JR, Stitzel ML, Morken MA, Huyghe JR, Fuchsberger C, Kuusisto J, Laakso M, Boehnke M, Collins FS, Mohlke KL. 2014. American journal of human genetics. 94: 186-197

A new common mutation in the cardiac beta-myosin heavy chain gene in Finnish patients with hypertrophic cardiomyopathy

Jääskeläinen Pertti, Heliö Tiina, Aalto-Setälä Katriina, Kaartinen Maija, Ilveskoski Erkki, Hämäläinen Liisa, Melin John, Kärkkäinen Satu, Peuhkurinen Keijo, Nieminen Markku S, Laakso Markku, the FinHCM MStudy Group, Kuusisto Johanna. 2014. Annals of medicine. 46: 424-429

Associations of erythrocyte membrane fatty acids with the concentrations of C-reactive protein, interleukin 1 receptor antagonist and adiponectin in1373 men

Takkunen MJ, de Mello VDF, Schwab US, Ågren JJ, Kuusisto J, Uusitupa MIJ. 2014. Prostaglandins leukotrienes and essential fatty acids. 91: 169-174

Defining the role of common variation in the genomic and biological architecture of adult human height

Wood Andrew R, Esko Tonu, Yang Jian, Vedantam Sailaja, Pers Tune H, Gustafsson Stefan, Chu Audrey Y, Estrada Karol, Luan Jian'an, Kutalik Zoltán, Amin Najaf, Buchkovich Martin L, Croteau-Chonka Damien C, Day Felix R, Duan Yanan, Fall Tove, Fehrmann Rudolf, Ferreira Teresa, Jackson Anne U, Karjalainen Juha et.al.. 2014. Nature genetics. 46: 1173-86

Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations

Ganesh SK, Chasman D, Larson MG, Guo X, Verwoert G, Bis JC, Gu X, Smith AV, Yang ML, Zhang Y, Ehret G, Rose LM, Hwang SJ, Papanicolau GJ, Sijbrands EJ, Rice K, Eiriksdottir G, Pihur V, Ridker PM, Vasan RS (including Kuusisto J, Laakso M). 2014. American journal of human genetics. 95: 49-65

Family history of type 2 diabetes increases the risk of both obesity and its complications: is type 2 diabetes a disease of inappropriate lipid storage?

Cederberg Henna, Stancakova Alena, Kuusisto Johanna, Laakso Markku, Smith Ulf. 2014. Journal of internal medicine. 277: 540-551

Fasting and OGTT-derived measures of insulin resistance as compared with the euglycemic-hyperinsulinemic clamp in non-diabetic Finnish offspring of type 2 diabetic individuals

Lorenzo Carlos, Haffner Steven M, Stancáková Alena, Kuusisto Johanna, Laakso Markku. 2014. Journal of clinical endocrinology and metabolism. 2015; 100: 544-550

Genome-wide Enrichment Analysis between Endometriosis and Obesity-related Traits Reveals Novel Susceptibility Loci

Rahmioglu Nilufer, Macgregor Stuart, Drong Alexander W, Hedman Åsa K, Harris Holly R, Randall Joshua C, Prokopenko Inga, The International EndoGene Consortium (IEC), The GIANT Consortium, Nyholt Dale R, Morris Andrew P, Montgomery Grant W, Missmer Stacey A, Lindgren Cecilia M, Zondervan Krina T. 2014. Human molecular genetics. Epub ahead of print: -

Genome-wide association study identifies three novel loci for type 2 diabetes

Hara Kazuo, Fujita Hayato, Johnson Todd A, Yamauchi Toshimasa, Yasuda Kazuki, Horikoshi Momoko, Peng Chen, Hu Cheng, Ma Ronald CW, Imamura Minako, Iwata Minoru, Tsunoda Tatsuhiko, Morizono Takashi, Shojima Nobuhiro, So Wing Yee, Leung Ting Fan, Kwan Patrick, Zhang Rong, Wang Jie, Yu Weihui et al. (including Kuusisto Johanna, Laakso Markku). 2014. Human molecular genetics. 23: 239-246

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium, Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, Ng MC, Prokopenko I, Saleheen D, Wang X, Zeggini E, Abec. 2014. Nature genetics. 46: 234-244

Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity

Dimas Antigone S, Lagou Vasiliki, Barker Adam, Knowles Joshua W, Mägi Reedik, Hivert Marie-France, Benazzo Andrea, Rybin Denis, Jackson Anne U, Stringham Heather M, Song Ci, Fischer-Rosinsky Antje, Boesgaard Trine Wellöw, Grarup Niels, Abbasi Fahim A, Assimes Themistocles L, Hao Ke, Yang Xia, Lecoeur Cécile, Barroso Inês et al (including Kuusisto Johanna, Laakso Markku). 2014. Diabetes. 63: 2158-2171

Insulin resistance and hyperglycaemia in cardiovascular disease development

Laakso Markku, Kuusisto Johanna. 2014. Nature reviews endocrinology. 10: 293-302

Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans

Männistö Ville T, Simonen Marko, Hyysalo Jenni, Soininen Pasi, Kangas Antti J, Kaminska Dorota, Matte Ananda K, Venesmaa Sari, Käkelä Pirjo, Kärjä Vesa, Arola Johanna, Gylling Helena, Cederberg Henna, Kuusisto Johanna, Laakso Markku, Yki-Järvinen Hannele, Ala-Korpela Mika, Pihlajamäki Jussi. 2014. Liver international. 2015; 35: 1853-1861

Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms

Claussnitzer Melina, Dankel Simon N, Klocke Bernward, Grallert Harald, Glunk Viktoria, Berulava Tea, Lee Heekyoung, Oskolkov Nikolay, Fadista Joao, Ehlers Kerstin, Wahl Simone, Hoffmann Christoph, Qian Kun, Rönn Tina, Riess Helene, Müller-Nurasyid Martina, Bretschneider Nancy, Schroeder Timm, Skurk Thomas, Horsthemke Bernhard et al. (including Kuusisto Johanna, Laakso Markku). 2014. Cell. 156: 343-358

Markers of tissue-specific insulin resistance predict the worsening of hyperglycemia, incident type 2 diabetes and cardiovascular disease

Fízelóvá Maria, Cederberg Henna, Stancakova Alena, Jauhiainen Raimo, Vangipurapu Jagadish, Kuusisto Johanna, Laakso Markku. 2014. PLoS ONE. 9: e109772

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes

Ng MC, Shriner D, Chen BH, Li J, Chen WM, Guo X, Liu J, Bielinski SJ, Yanek LR, Nalls MA, Comeau ME, Rasmussen-Torvik LJ, Jensen RA, Evans DS, Sun YV, An P, Patel SR, Lu Y, Long J, Armstrong LL et al. (including Kuusisto J, Laakso M). 2014. PLoS genetics. 10: e1004517

Multi-ethnic fine-mapping of 14 central adiposity loci

Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR, Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu J, Li G, Ruiz-Narvaez EA, Chen WM et al. (including Kuusisto J, Laakso M). 2014. Human molecular genetics. 23: 4738-4744

Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index

Hoggart Clive J, Venturini Giulia, Mangino Massimo, Gomez Felicia, Ascari Giulia, Zhao Jing Hua, Teumer Alexander, Winkler Thomas W, T¨ernikova Natalia, Luan Jian'an, Mihailov Evelin, Ehret Georg B, Zhang Weihua, Lamparter David, Esko Tõnu, Macé Aurelian, Rüeger Sina, Bochud Pierre-Yves, Barcella Matteo, Dauvilliers Yves et al (including Atalay Mustafa, Kuusisto Johanna, Lakka Timo, Yaluri Alena, Laakso Markku, Uusitupa Matti). 2014. PLoS genetics. 10: e1004508

Quality control and conduct of genome-wide association meta-analyses

Winkler Thomas W, Day Felix R, Croteau-Chonka Damien C, Wood Andrew R, Locke Adam E, Mägi Reedik, Ferreira Teresa, Fall Tove, Graff Mariaelisa, Justice Anne E, Luan Jian'an, Gustafsson Stefan, Randall Joshua C, Vedantam Sailaja, Workalemahu Tsegaselassie, Kilpeläinen Tuomas O, Scherag André, Esko Tonu, Kutalik Zoltán, Heid Iris M, The Genetic Investigation of Anthropometric Traits (GIANT) Consortium et al. (including Atalay Mustafa, Kuusisto Johanna, Laakso Markku, Yaluri Alena). 2014. Nature physics. 9: 1192-1212

Sepelvaltimoiden pallolaajennushoidon tulokset ja vaikutus potilaiden vointiin ja oireisiin

Kemiläinen H, Kaulamo J, Heikkinen O, Miettinen H, Kuusisto J. 2014. Duodecim. 130: 63-70

A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.

Li H, Gan W, Lu L, Dong X, Han X, Hu C, Yang Z, Sun L, Bao W, Li P, He M, Sun L, Wang Y, Zhu J, Ning Q, Tang Y, Zhang R, Wen J, Wang D, Zhu X, et al. (including Kuusisto J, Laakso M). 2013. Diabetes. 62: 291-298

Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss

Kaminska D, Hämäläinen M, Cederberg H, Käkelä P, Venesmaa S, Miettinen P, Ilves I, Herzig KH, Kolehmainen M, Karhunen L, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. 2013. Diabetologia. Epub 2013 Nov 7.: 1-5

Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes

Mahendran Y, Ågren J, Uusitupa M, Cederberg H, Vangipurapu J, Stancakova A, Schwab U, Kuusisto J, Laakso M. 2013. American journal of clinical nutrition. -: -

Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men

Mahendran Y, Vangipurapu J, Cederberg H, Stancáková A, Pihlajamäki J, Soininen P, Kangas AJ, Paananen J, Civelek M, Saleem NK, Pajukanta P, Lusis AJ, Bonnycastle LL, Morken MA, Collins FS, Mohlke KL, Boehnke M, Ala-Korpela M, Kuusisto J, Laakso M. 2013. Diabetes. 62: 3618-3626

Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts

Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, Wood AR, Michaëlsson K, Vandenput L, Zgaga L, Yerges-Armstrong LM, McCarthy MI, Dupuis J, Kaakinen M, Kleber ME, Jameson K, et al. (including Laakso M, Kuusisto J). 2013. PLoS medicine. 10: e1001383

Common variants associated with plasma triglycerides and risk for coronary artery disease

Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang H-Y, Demirkan A, Den Hertog HM, Donnelly LA, Ehret GB, Esko T et.al.. 2013. Nature genetics. 45: 1345-52

Desmosterol in human nonalcoholic steatohepatitis

Simonen M, Männistö V, Leppänen J, Kaminska D, Kärjä V, Venesmaa S, Käkelä P, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. 2013. Hepatology. 58: 976-982

Dietary fat in relation to erythrocyte fatty acid composition in men

Takkunen M, Ågren J, Kuusisto J, Laakso M, Uusitupa M, Schwab U. 2013. Lipids. 48: 1093-1102

Discovery and refinement of loci associated with lipid levels

Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang H-Y, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF et.al.. 2013. Nature genetics. 45: 1274-1283

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

Huyghe JR, Jackson AU, Fogarty MP, Buchkovich ML, Stancáková A, Stringham HM, Sim X, Yang L, Fuchsberger C, Cederberg H, Chines PS, Teslovich TM, Romm JM, Ling H, McMullen I, Ingersoll R, Pugh EW, Doheny KF, Neale BM, Daly MJ, et al (including J Kuusisto, M Laakso). 2013. Nature genetics. 45: 197-201

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes

Albrechtsen A, Grarup N, Li Y, Sparsø T, Tian G, Cao H, Jiang T, Kim SY, Korneliussen T, Li Q, Nie C, Wu R, Skotte L, Morris AP, Ladenvall C, Cauchi S, Stančáková A, Andersen G, Astrup A, Banasik K, et al. (including Stancakova A, Kuusisto J, Laakso M). 2013. Diabetologia. 56: 298-310

Genetic Loci for Retinal Arteriolar Microcirculation

Sim X, Jensen RA, Ikram MK, Cotch MF, Li X, MacGregor S, Xie J, Smith AV, Boerwinkle E, Mitchell P, Klein R, Klein BE, Glazer NL, Lumley T, McKnight B, Psaty BM, de Jong PT, Hofman A, Rivadeneira F, Uitterlinden AG et al (including M Laakso, J Kuusisto). 2013. PLoS ONE. 8: e65804

Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits

Civelek M, Hagopian R, Pan C, Che N, Yang WP, Kayne PS, Saleem NK, Cederberg H, Kuusisto J, Gargalovic PS, Kirchgessner TG, Laakso M, Lusis AJ.. 2013. Human molecular genetics. 22: 3023-3037

Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21

Tabassum R, Chauhan G, Dwivedi OP, Mahajan A, Jaiswal A, Kaur I, Bandesh K, Singh T, Mathai BJ, Pandey Y, Chidambaram M, Sharma A, Chavali S, Sengupta S, Ramakrishnan L, Venkatesh P, Aggarwal SK, Ghosh S, Prabhakaran D, Srinath RK, et al (including M Laakso, J Kuusisto). 2013. Diabetes. 62: 977-986

Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.

Saxena R, Saleheen D, Been LF, Garavito ML, Braun T, Bjonnes A, Young R, Ho WK, Rasheed A, Frossard P, Sim X, Hassanali N, Radha V, Chidambaram M, Liju S, Rees SD, Ng DP, Wong TY, Yamauchi T, Hara K, et al. (including J Kuusisto, M Laakso). 2013. Diabetes. 62: 1746-1755

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, Luan J, Randall JC, Vedantam S, Willer CJ, Winkler TW, et al. (including Atalay M, Kuusisto J, Lakka TA, Stancakova A, Laakso M, Uusitupa M). 2013. Nature genetics. 45: 501-512

Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men

Mahendran Yuvaraj, Cederberg Henna, Vangipurapu Jagadish, Kangas Antti J, Soininen Pasi, Kuusisto Johanna, Uusitupa Matti, Ala-Korpela Mika, Laakso Markku. 2013. Diabetes care. 36: 3732-3738

Idiopathic dilated cardiomyopathy and chronic atrial fibrillation

Tuomainen PO, Magga J, Fedacko J, Kärkkäinen S, Miettinen K, Vanninen E, Kuusisto J, Peuhkurinen KJ. 2013. Clinical physiology and functional imaging. e-pub: e-pub

Link between GIP and osteopontin in adipose tissue and insulin resistance

Ahlqvist E, Osmark P, Kuulasmaa T, Pilgaard K, Omar B, Brøns C, Kotova O, Zetterqvist AV, Stancáková A, Jonsson A, Hansson O, Kuusisto J, Kieffer TJ, Tuomi T, Isomaa B, Madsbad S, Gomez MF, Poulsen P, Laakso M, Degerman E, et al. (including Pihlajamäki J). 2013. Diabetes. 62: 2088-2094

Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.

Yaghootkar H, Lamina C, Scott RA, Dastani Z, Hivert M-F, Warren LL, Stancáková A, Buxbaum SG, Lyytikäinen L-P, Henneman P, Wu Y, Cheung CYY, Pankow JS, Jackson AU, Gustafsson S, Zhao JH, Ballantyne CM, Xie W, Bergman RN, Boehnke M et al. (including J Kuusisto, M Laakso, J Paananen). 2013. Diabetes. 62: 3589-3598

Meta-analysis of gene-level associations for rare variants based on single-variant statistics

Hu Y-J, Berndt SI, Gustafsson S, Ganna A, Genetic Investigation of ANthropometric Traits (GIANT) Consortium (including M Atalay, T Lakka, J Kuusisto, M Laakso), Hirschhorn J, North KE, Ingelsson E, Lin D-Y et.al.. 2013. American journal of human genetics. 93: 236-248

Mining the human phenome using allelic scores that index biological intermediates

Evans DM, Brion MJ, Paternoster L, Kemp JP, McMahon G, Munafò M, Whitfield JB, Medland SE, Montgomery GW; GIANT Consortium; CRP Consortium; TAG Consortium, Timpson NJ, St Pourcain B, Lawlor DA, Martin NG, Dehghan A, Hirschhorn J, Davey Smith G et al. (including M Laakso ja J Kuusisto). 2013. PLoS genetics. 9: e1003919

Non-cholesterol sterol levels predict hyperglycemia and conversion to type 2 diabetes in finnish men

Cederberg H, Gylling H, Miettinen TA, Paananen J, Vangipurapu J, Pihlajamäki J, Kuulasmaa T, Stancáková A, Smith U, Kuusisto J, Laakso M. 2013. PLoS ONE. 8: e67406

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, Workalemahu T, Feitosa MF, Croteau-Chonka DC, Day FR, Fall T, Ferreira T, Gustafsson S, Locke AE, Mathieson I, Scherag A, et al. (including J Kuusisto, M Laakso, M Atalay, T Lakka). 2013. PLoS genetics. 9: e1003500

The SH2B1 obesity locus and abnormal glucose homeostasis: lack of evidence for association from a meta-analysis in individuals of European ancestry

Prudente S, Copetti M, Morini E, Mendonca C, Andreozzi F, Chandalia M, Baratta R; DIAGRAM consortium (including Kuusisto J, Laakso M), Pellegrini F, Mercuri L, Bailetti D, Abate N, Frittitta L, Sesti G, Florez JC, Doria A, Trischitta V. 2013. Nutrition metabolism and cardiovascular diseases. 23: 1043-1049

Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

Wu Y, Waite LL, Jackson AU, Sheu WH, Buyske S, Absher D, Arnett DK, Boerwinkle E, Bonnycastle LL, Carty CL, Cheng I, Cochran B, Croteau-Chonka DC, Dumitrescu L, Eaton CB, Franceschini N, Guo X, Henderson BE, Hindorff LA, Kim E, et al. (including Stancakova A, Kuusisto J, Laakso M, Uusitupa M, Rauramaa R Lakka T.). 2013. PLoS genetics. 9: e1003379

Two founder mutations in the alpha-tropomyosin and the cardiac myosin-binding protein C genes are common causes of hypertrophic cardiomyopathy in the Finnish population

Jääskeläinen P, Heliö T, Aalto-Setälä K, Kaartinen M, Ilveskoski E, Hämäläinen L, Melin J, Nieminen MS, Laakso M, Kuusisto J; FinHCM study group, Kervinen H, Mustonen J, Juvonen J, Niemi M, Uusimaa P, Huttunen M, Kotila M, Pietilä M.. 2013. Annals of medicine. 45: 85-90

Update on type 2 diabetes as a cardiovascular disease risk equivalent

Kuusisto J, Laakso M. 2013. Current cardiology reports. 15: 331

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Manning AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, Rybin D, Liu CT, Bielak LF, Prokopenko I, Amin N, Barnes D, Cadby G, Hottenga JJ, Ingelsson E, Jackson AU, Johnson T, Kanoni S, Ladenvall C, Lagou V et.al.. 2012. Nature genetics. 44: 659-669

A genome-wide association search for type 2 diabetes genes in African Americans

Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN, Bostrom MA, Rudock ME, Talbert ME, Lewis JP; DIAGRAM Consortium; MAGIC Investigators, Ferrara A, Lu L, Ziegler JT, Sale MM, Divers J, Shriner D et.al.. 2012. PLoS ONE. 7: e29202

A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.

Imamura M, Maeda S, Yamauchi T, Hara K, Yasuda K, Morizono T, Takahashi A, Horikoshi M, Nakamura M, Fujita H, Tsunoda T, Kubo M, Watada H, Maegawa H, Okada-Iwabu M, Iwabu M, Shojima N, Ohshige T, Omori S, Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium (including M Laakso, J Kuusisto). 2012. Human molecular genetics. 21: 3042-3049

Adipose Co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes

Haas BE, Horvath S, Pietiläinen KH, Cantor RM, Nikkola E, Weissglas-Volkov D, Rissanen A, Civelek M, Cruz-Bautista I, Riba L, Kuusisto J, Kaprio J, Tusie-Luna T, Laakso , Aguilar-Salinas CA, Pajukanta P. 2012. Bmc medical genomics. 5: 61

Association between liver insulin resistance and cardiovascular risk factors

Vangipurapu Jagadish, Stančáková A, Kuulasmaa Teemu, Soininen Pasi, Kangas AJ, Ala-Korpela Mika, Kuusisto Johanna, Laakso Markku. 2012. Journal of internal medicine. 272: 402-408

Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

Stahl EA, Wegmann D, Trynka G, Gutierrez-Achury J, Do R, Voight BF, Kraft P, Chen R, Kallberg HJ, Kurreeman FA; Diabetes Genetics Replication and Meta-analysis Consortium; Myocardial Infarction Genetics Consortium, Kathiresan S, Wijmenga C, Gregersen PK, Alfredsson L, Siminovitch KA, Worthington J, de Bakker PI, Raychaudhuri S, Plenge RM. 2012. Nature genetics. 44: 483-489

Circadian gene variants and susceptibility to type 2 diabetes: a pilot study

Kelly MA, Rees SD, Hydrie MZI, Shera AS, Bellary S, O¿Hare JP, Kumar S, Taheri S, Basit A, Barnett AH, DIAGRAM consortium, SAT2D consortium. 2012. PLoS ONE. 7: e32670

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women

Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K; GIANT Consortium; MAGIC Consortium; GLGC Consortium, Johnson AD, Foster MC, Greenawalt DM, Griffin P, Ding J, Newman AB, Tylavsky F, Miljkovic I, Kritchevsky SB, Launer L et.al.. 2012. PLoS genetics. 8: e1002695

Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations

Demirkan A, van Duijn CM, Ugocsai P, Isaacs A, Pramstaller PP, Liebisch G, Wilson JF, Johansson Å, Rudan I, Aulchenko YS, Kirichenko AV, Janssens AC, Jansen RC, Gnewuch C, Domingues FS, Pattaro C, Wild SH, Jonasson I, Polasek O, Zorkoltseva IV et.al.. 2012. PLoS genetics. 8: e1002490

Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits

Kristiansson Kati, Perola Markus, Tikkanen Emmi, Kettunen Johannes, Surakka Ida, Havulinna Aki S, Stancáková Alena, Barnes Chris, Widen Elisabeth, Kajantie Eero, Eriksson Johan G, Viikari Jorma, Kähönen Mika, Lehtimäki Terho, Raitakari Olli T, Hartikainen Anna-Liisa, Ruokonen Aimo, Pouta Anneli, Jula Antti, Kangas Antti J et al. 2012. Circulation: cardiovascular genetics. 5: 242-249

Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men

Stancáková Alena, Civelek Mete, Saleem Niyas K, Soininen Pasi, Kangas Antti J, Cederberg Henna, Paananen Jussi, Pihlajamäki Jussi, Bonnycastle Lori L, Morken Mario A, Boehnke Michael, Pajukanta Päivi, Lusis Aldons J, Collins Francis S, Kuusisto Johanna, Ala-Korpela Mika, Laakso Markku. 2012. Diabetes. 61: 1895-1902

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN, Gao P, Saleheen D, Rendon A, Nelson CP, Braund PS, Hall AS, Chasman DI, Tybjaerg-Hansen A, Chambers JC, Benjamin EJ, Franks PW, Clarke R, Wilde AAM, Trip MD et.al.. 2012. The Lancet. 379: 1205-1213

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik L, Yengo L, Lecoeur C, Shungin D, Sanna S, Sidore C, Johnson PCD, Jukema JW, Johnson T et.al.. 2012. Nature genetics. 44: 991-1005

Large-scale association analysis identifies new risk loci for coronary artery disease

The CARDIoGRAMplusC4D Consortium (including M Laakso, J Kuusisto), Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, Stirrups K, König IR, Cazier JB, Johansson A, Hall AS, Lee JY, Willer CJ, Chambers JC, Esko T et al. 2012. Nature genetics. 45: 25-33

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, Prokopenko I, Kang HM, Dina C, Esko T, Fraser RM, Kanoni S, Kumar A, Lagou V, Langenberg C, Luan J et.al.. 2012. Nature genetics. 44: 981-990

Lipoprotein subclass profiles in individuals with varying degrees of glucose tolerance: a population-based study of 9399 Finnish men

Wang J, Stančáková A, Soininen P, Kangas AJ, Paananen J, Kuusisto J, Ala-Korpela M, Laakso M. 2012. Journal of internal medicine. 272: 562-572

Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk

Marquez M, Huyvaert M, Perry JR, Pearson RD, Falchi M, Morris AP, Vivequin S, Lobbens S, Yengo L, Gaget S, Pattou F, Poulain-Godefroy O, Charpentier G, Carlsson LM, Jacobson P, Sjöström L, Lantieri O, Heude B, Walley A, Balkau B, Marre M, Froguel P, Cauchi S; DIAGRAM Consortium. 2012. Diabetes. 61: 524-530

Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy

Kuusisto J, Kärjä V, Sipola P, Kholová I, Peuhkurinen K, Jääskeläinen P, Naukkarinen A, Ylä-Herttuala S, Punnonen K, Laakso M. 2012. Heart. 98: 1007-1013

No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels

Scott RA, Chu AY, Grarup N, ManningAK, Hivert M-F, Shungin D, Tönjes A, Yesupriya A, Barnes D, Bouatia-Naji N, Glazer NL, Jackson AU, Kutalik Z, Lagou V, Marek D, Rasmussen-Torvik LJ, Stringham HM, Tanaka T, Aadah M, Arking DE et.al.. 2012. Diabetes. 61: 1291-1296

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.

Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, Beekman M, Coassin S, Lohman K, Qi L, Kanoni S et.al.. 2012. PLoS genetics. 8: e1002607

A Common Variant in TFB1M Is Associated with Reduced Insulin Secretion and Increased Future Risk of Type 2 Diabetes

Koeck T, Olsson AH, Nitert MD, Sharoyko VV, Ladenvall C, Kotova O, Reiling E, Rönn T, Parikh H, Taneera J, Eriksson JG, Metodiev MD, Larsson NG, Balhuizen A, Luthman H, Stančáková A, Kuusisto J, Laakso M, Poulsen P, Vaag A. 2011. Cell metabolism. 13: 80-91

A novel surrogate index for hepatic insulin resistance

Vangipurapu J, Stancakova A, Kuulasmaa T, Paananen J, Kuusisto J, EGIR-RISC Study Group, Ferrannini E, Laakso M. 2011. Diabetologia. 54: 540-543

A role for coding functional variants in HNF4A in type 2 diabetes susceptibility

Jafar-Mohammadi B, Groves CJ, Gjesing AP, Herrera BM, Winckler W, Stringham HM, Morris AP, Lauritzen T, Doney ASF, Morris AD, Weedon MN, Swift AJ, Kuusisto J, Laakso M, Altshuler D, Hattersley AT, Collins FS, Boehnke M, Hansen T, Pedersen O, Palmer CNA, Frayling TM, DIAGRAM Consortium, Gloyn AL, McCarthy MI. 2011. Diabetologia. 54: 111-119

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.

Fox ER, Young JH, Li Y, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC, Ganesh S, Kutlar A, Ramachandran VS, Polak JF, Fabsitz RR, Dries DL, Farlow DN, Redline S, Adeyemo A, Hirschorn JN, Sun YV, Wyatt SB, Penman AD, Palmas W, Rotter JI, Townsend RR, Doumatey AP, Tayo BO, Mosley TH Jr, Lyon HN, Kang SJ, Rotimi CN, Cooper RS, Franceschini N, Curb JD, Martin LW, Eaton CB, Kardia SL, Taylor HA, Caulfield MJ, Ehret GB, Johnson T; International Consortium for Blood Pressure Genome-wide Assoc. 2011. Human molecular genetics. 20: 2273-2284

Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men

Vangipurapu J, Stancakova A, Pihlajamäki J, Kuulasmaa TM, Kuulasmaa T, Paananen J, Kuusisto J, Ferrannini E, Laakso M. 2011. Diabetologia. 54: 563-571

Cardiac MRI assessed left ventricular hypertrophy in differentiating hypertensive heart disease from hypertrophic cardiomyopathy attributable to a sarcomeric gene mutation

Sipola P, Magga J, Husso M, Jääskeläinen P, Peuhkurinen K, Kuusisto J. 2011. European radiology. 21: 1383-1389

Effects of 34 Risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men

Stancáková A, Paananen J, Soininen P, Kangas AJ, Bonnycastle LL, Morken MA, Collins FS, Jackson AU, Boehnke ML, Kuusisto J, Ala-Korpela M, Laakso M. 2011. Diabetes. 60: 1608-1616

Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles

Haas BE, Weissglas-Volkov D, Aguilar-Salinas CA, Nikkola E, Vergnes L, Cruz-Bautista I, Riba L, Stancakova A, Kuusisto J, Soininen P, Kangas AJ, Ala-Korpela M, Tusie-Luna T, Laakso M, Pajukanta P. 2011. Arteriosclerosis, thrombosis, and vascular biology. 31: 1201-1207

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O'Reilly PF, Amin N, Bragg-Gresham JL, Teumer A, Glazer NL, Launer L, Zhao JH et. al.. 2011. Nature. 478: 103-109

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Kilpeläinen TO, Zillikens MC, Stančáková A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L, Styrkarsdottir U, Zhou Y, Smith AV, Zhao JH, Amin N, Vedantam S, Shin SY, Haritunians T, Fu M, Feitosa MF, Kumari M et al.. 2011. Nature genetics. 43: 753-760

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits

Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, Nalls MA, Clark JM, Mitchell BD, Shuldiner AR, Butler JL, Tomas M, Hoffmann U, Hwang SJ, Massaro JM, O'Donnell CJ, Sahani DV, Salomaa V, Schadt EE, Schwartz SM, Siscovick DS; NASH CRN; GIANT Consortium; MAGIC Investigators (including M. Laakso), Voight BF, Carr JJ, Feitosa MF, Harris TB, Fox CS, Smith AV, Kao WH, Hirschhorn JN, Borecki IB; GOLD Consortium:. 2011. PLoS genetics. 7: e1001324

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME, Bouatia-Naji N, Dimas AS, Nica A, Wheeler E, Chen H, Voight BF, Taneera J, Kanoni S, Peden JF, Turrini F, Gustafsson S, Zabena C, et al. 2011. Diabetes. 60: 2624-2534

Glomerular filtration rate and parathyroid hormone are associated with 1,25-dihydroxyvitamin D in men without chronic kidney disease

Karhapää P, Pihlajamäki J, Pörsti I, Kastarinen M, Mustonen J, Niemelä O, Tuomi H, Kuusisto J.. 2011. Journal of internal medicine. 2011: online

Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B

Hribal ML, Presta I, Procopio T, Marini MA, Stančáková A, Kuusisto J, Andreozzi F, Hammarstedt A, Jansson PA, Grarup N, Hansen T, Walker M, Stefan N, Fritsche A, Häring HU, Pedersen O, Smith U, Laakso M, Sesti G; on behalf of the EUGENE2 Consortium. 2011. Diabetologia. 54: 795-802

Late gadolinium enhanced cardiovascular magnetic resonance of lamin A/C gene mutation related dilated cardiomyopathy

Holmström M, Kivistö S, Heliö T, Jurkko R, Kaartinen M, Antila M, Reissell E, Kuusisto J, Kärkkäinen S, Peuhkurinen K, Koikkalainen J, Lötjönen J, Lauerma K. 2011. Journal of cardiovascular magnetic resonance. 13: 30

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.

Cho YS, Chen CH, Hu C, Long J, Ong RT, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang YC, Kwak SH, Ma RC, Yamamoto K, Adair LS, Aung T, Cai Q, Chang LC, Chen YT,... Kuusisto J, Laakso M. 2011. Nature genetics. 44: 67-72

Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children

Kilpeläinen Tuomas O, Qi Lu, Brage Soren, Sharp Stephen J., Sonestedt Emily, Demerath Ellen, Ahmad Tariq, Mora Samia, Kaakinen Marika, Sandholt Camilla H, Holzapfel Christina, Autenrieth Christine S., Hyppönen Elina, Cauchi Stéphane , He Meian, Kutalik Zoltan, Kumari Meena, Stancaková Alena, Meidtner Karina, Balkau Beverley et al.. 2011. PLoS medicine. 8: e1001116

Pleiotropic Effects of GIP on Islet Function Involves Osteopontin

Lyssenko V, Eliasson L, Kotova O, Pilgaard K, Wierup N, Salehi A, Wendt A, Jonsson A, De Marinis YZ, Berglund LM, Taneera J, Balhuizen A, Hansson O, Osmark P, Dunér P, Brøns C, Stancáková A, Kuusisto J, Bugliani M, Saxena R, et al.. 2011. Diabetes. 60: 2424-2433

Prevalence of Anderson-Fabry disease in patients with hypertrophic cardiomyopathy: the European Anderson-Fabry disease study

Elliott P, Baker R, Pasquale F, Quarta G, Ebrahim H, Mehta AB, Hughes DA on behalf of the ACES study group. 2011. Heart. 97: 1957-1960

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stančáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, Farese RV Jr, Kahn CR, et al.. 2011. Molecular cell. 44: 177-190

Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans

Pihlajamäki J, Kuulasmaa T, Kaminska D, Simonen M, Kärjä V, Grönlund S, Käkelä P, Pääkkönen M, Kainulainen S, Punnonen K, Kuusisto J, Gylling H, Laakso M. 2011. Journal of hepatology. 56: 663-670

Serum lipidomics meets cardiac magnetic resonance imaging: profiling of subjects at risk of dilated cardiomyopathy

Sysi-Aho M, Koikkalainen J, Seppänen-Laakso T, Maartinen M, Kuusisto J, Peuhkurinen K, Kärkkäinen S, Antila M, Lauerma K, Reissell E, Jurkko R, Lötjönen J, Heliö T, Oresic M. 2011. PLoS ONE. 6: e15744

The Birth Weight Lowering C-Allele of rs900400 Near LEKR1 and CCNL1 Associates with Elevated Insulin Release following an Oral Glucose Challenge

Andersson EA, Harder MN, Pilgaard K, Pisinger C, Stančáková A, Kuusisto J, Grarup N, Færch K, Poulsen P, Witte DR, Jørgensen T, Vaag A, Laakso M, Pedersen O, Hansen T. 2011. PLoS ONE. 6: e27096

The Lin28/let-7 axis regulates glucose metabolism

Zhu H, Shyh-Chang N, Segrè AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, Urbach A, Thornton JE, Triboulet R, Gregory RI; DIAGRAM Consortium; MAGIC Investigators, Altshuler D, Daley GQ. 2011. Cell. 147: 81-94

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren CM, ..., Kuusisto J, ..., Laakso M, et al.. 2010. Nature genetics. 42: 937-948

Association of the FTO gene variant (rs9939609) with cardiovascular disease in men with abnormal glucose metabolism - The Finnish Diabetes Prevention Study

Lappalainen T, Kolehmainen M, Schwab US, Tolppanen AM, Stančáková A, Lindström J, Eriksson JG, Keinänen-Kiukaanniemi S, Aunola S, Ilanne-Parikka P, Herder C, Koenig W, Gylling H, Kolb H &Tuomilehto J for the Finnish diabetes prevention study group. 2010. Nutrition metabolism and cardiovascular diseases. 2011/21: 691-698/2011

Circulating TNF-alpha and IL-6 concentrations and TNF-alpha-308 G > A polymorphism in children with premature adrenarche

Utriainen P, Jääskeläinen J, Gröhn O, Kuusisto J, Pulkki K & Voutilainen R. 2010. Frontiers in endocrinology. 1: doi: 10.3389/fendo.2010.00006, Article 6: 1-6

Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways

Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, Dupuis J, Bouatia-Naji N, Langenberg C, Prokopenko I, Stolerman E, Sandhu MS, Heeney MM, Devaney JM, Reilly MP, Ricketts SL, Stewart AF, Voight BF, Willenborg C, Wright B, Altshuler D, et al. on behalf of Procardis Consortium. 2010. Diabetes. 59: 3229-3239

Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans

Ingelsson E, Langenberg C, Hivert MF, ProkopenkoI, Lyssenko V, Dupuis J, Mägi R, Sharp S, ..., Kuusisto J, Laakso M, et al. 2010. Diabetes. 59: 1266-1275

Diverse associations of 25-hydroxyvitamin D and 1,25-dihydroxy-vitamin D with dyslipidaemias

Karhapää P, Pihlajamäki J, Pörsti I, Kastarinen M, Mustonen J, Niemelä P, Kuusisto J. 2010. Journal of internal medicine. 268: 604-610

Four Novel loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo

Ikram MK, Xueling S, Jensen RA, Cotch MF, Hewitt AW, Ikram MA, Wang JJ, Klein R, Klein BE, Breteler MMB, et al.. 2010. PLoS ONE. 6: e1001184

Genetic evidence that raised Sex Hormone Binding Globulin (SHBG) levels reduce the risk of type 2 diabetes

Perry JR, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T, Thorleifsson G, ..., Kuusisto J, ..., Laakso M, et al. 2010. Human molecular genetics. 19: 535-544

Genetic variation in gastric inhibitory polypeptide receptor (GIPR): Impacts the glucose and insulin responses to an oral glucose challenge

Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, Bouatia-Naji N, .., Kuusisto J, Laakso M, et al.. 2010. Nature genetics. 42: 142-148

Identification of undiagnosed type 2 diabetic individuals by the Finnish diabetes risk score, biochemical and genetic markers: A population-based study of 7232 Finnish men

Wang J, Stancakova A, Kuusisto J, Laakso M. 2010. Journal of clinical endocrinology and metabolism. 95: 3858-3862

Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity. Lessons from the METSIM study.

Gylling H, Hallikainen M, Pihlajamaki J, Simonen P, Kuusisto J, Laakso M, Miettinen TA.. 2010. Journal of lipid research. 51: 2422-2427

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Kuusisto J, Laakso M, et al.. 2010. Nature genetics. 42: 105-116

Pregnancy and childhood in carriers of the lamin A/C-gene mutation

Palojoki E, Kaartinen M, Kaaja R, Reissell E, Kärkkäinen S, Kuusisto J, Heliö T. 2010. European journal of heart failure. 12: 630-633

The D299G/T3991 toll-like receptor 4 variant associates with body and liver fat: results from the TULIP and METSIM studies

Weyrich P, Staiger H, Stancakova A, Machicao F, Machann J, Schick F, Stefan N, Kuusisto J, Laakso M, Schäfer S, Fritsche A, Häring H-U. 2010. PLoS ONE. 5: e13980

The metabolic syndrome predicts incident congestive heart failure: a 20-year follow-up study of elderly Finns

Wang J, Sarnola K, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M & Kuusisto J. 2010. Atherosclerosis. 210: 237-242

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Voight BF,Scott LJ,Steinthorsdottir V,Morris AP,Dina C,Welch RP,Zeggini E,Huth C,..., ,Kuusisto J,..., Laakso M,et al.. 2010. Nature genetics. 42: 579-589

Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose

Li X, Shu Y-H, Xiang AH, Trigo E, Kuusisto J, Hartiala J, Swift AJ, Kawakubo M, Stringham HM, Bonnycastle LL, Lawrence JM, Laakso M, Allayee H, Buchanan TA, Watanabe RM. 2009. Diabetes. 58: 2946-2953

Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men

Stancáková A, Kuulasmaa T, Paananen J, Jackson AU, Bonnycastle LL, Collins FS, Boehnke M, Kuusisto J, Laakso M. 2009. Diabetes. 58: 2129-2136

Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes

Müssig K, Staiger H, Machicao F, Stancáková A, Kuusisto J, Laakso M, Thamer C, Machann J, Schick F, Claussen CD, Stefan N, Fritsche A, Häring H-U. 2009. Journal of clinical endocrinology and metabolism. 94: 1353-1360

Cardiac sympathetic activity is associated with inflammation and neurohumoral activation in patients with idiopathic dilated cardiomyopathy

Turpeinen AK, Vanninen E, Magga J, Tuomainen P, Kuusisto J, Sipola P, Punnonen K, Vuolteenaho O, Peuhkurinen K. 2009. Clinical physiology and functional imaging. 29: 414-419

Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men

Stancáková A, Javorský M, Kuulasmaa T, Haffner SM, Kuusisto J, Laakso M. 2009. Diabetes. 58: 1212-1221

Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects

Weyrich P, Staiger H, Stancáková A, Schäfer SA, Kirchhoff K, Ullrich S, Ranta F, Gallwitz B, Stefan N, Machicao F, Kuusisto J, Laakso M, Fritsche A, Häring H-U. 2009. Bmc medical genetics. 10: 77

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

Lyssenko V, Nagorny CLF, Erdos MR, Wierup N, Jonsson A, Spégel P, Bugliani M, Saxena R, Fex M, Pulizzi N, Isomaa B, Tuomi T, Nilsson P, Kuusisto J, Tuomilehto J, Boehnke M..., Laakso M, Marchetti P, Watanabe RM, Mulder H, Groop L. 2009. Nature genetics

Common variants at 30 loci contribute to polygenic dyslipidemia

Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T..., Kuusisto J, Bergman RN..., Laakso M, Ferrucci L, Scheet P..., Dupuis J, de Bakker PI, O'Donnell CJ, Chambers JC, Kooner JS. 2009. Nature genetics. 41: 56-65

Galanin preproprotein is associated with elevated plasma triglycerides

Plaisier CL, Kyttälä M, Weissglas-Volkov D, Sinsheimer JS, Huertas-Vazquez A..., Pullinger CR, Malloy MJ, Kane JP, Cruz-Bautista I, Herrera MF, Aguilar-Salinas C, Kuusisto J, Laakso M, Taskinen MR, van der Kallen CJ, Pajukanta P. 2009. Arteriosclerosis, thrombosis, and vascular biology. 29: 147-152

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM..., Cherkas L, Chines P, Coin L, Cooper C, Crawford G, Doering A, Dominiczak A, Doney..., Laakso M, Kuusisto J. 2009. PLoS genetics. 5: e1000508

Genome-wide association study identifies eight loci associated with blood pressure

Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS..., Lucas G, Kuusisto J, Burton PR, Hadley D, McArdle WL, Wellcome TRUST Case Control Consortium, Brown M, Dominiczak A, Newhouse SJ, Samani NJ..., Laakso M. 2009. Nature genetics. 41: 666-676

Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics

Koutnikova H, Laakso M, Lu L, Combe R, Paananen J, Kuulasmaa T, Kuusisto J, Häring H-U, Hansen T, Pedersen O, Smith U, Hanefeld M, Williams RW, Auwerx J. 2009. PLoS genetics. 5: e100591

Parental origin of sequence variants associated with complex diseases

Kong A, Steinthorsdottir V, Masson G, Thorleifsson G..., ...Johannsson OT, Hreidarsson AB, Sigurdsson G, DIAGRAM Consortium, Laakso M, Kuusisto J. 2009. Nature. 462: 868-874

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N..., Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Kuusisto J, Laakso M. 2009. Nature genetics. 41: 25-34

The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels

Meex SJR, Weissglas-Volkov D, van der Kallen CJH, Thuerauf DJ, van Greevenbroek MMJ, Schalkwijk CG, Stehouwer CDA, Feskens EJM, Heldens L, Ayoubi TA, Hofker MH, Wouters BG..., Taskinen M-R, Kuusisto J, Laakso M, de Bruin TWA.... 2009. Arteriosclerosis, thrombosis, and vascular biology. 29: 1322-1327

Underlying genetic models of inheritance in established type 2 diabetes associations

Salanti G, Southam L, Altshuler D, Ardlie K, Barroso I, Boehnke M, Cornelis MC, Frayling TM, Grallert H, Grarup N, Groop L, Hansen T, Hattersley AT, Hu FB, Hveem K, Illig T, Kuusisto J, Laakso M, Langenberg C.... 2009. American journal of epidemiology. 170: 537-545

Variants in MTNR1B influence fasting glucose levels

Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, Kaakinen M, Lyssenko V, Chen WM, Ahmadi K..., Kuusisto J, Laakso M. 2009. Nature genetics. 41: 77-81

Clinical significance of troponin I efflux and troponin autoantibodies in patients with dilated cardiomyopathy

Miettinen KH, Eriksson S, Magga J, Tuomainen P, Kuusisto J, Vanninen EJ, Turpeinen A, Punnonen KR, Pettersson K, Peuhkurinen KJ. 2008. Journal of cardiac failure. 14: 481-488

Cytokines, interstitial collagen and ventricular remodelling in dilated cardiomyopathy

Timonen P, Magga J, Risteli J, Punnonen K, Vanninen E, Turpeinen A, Tuomainen P, Kuusisto J, Vuolteenaho O, Peuhkurinen K. 2008. International journal of cardiology. 124: 293-300

Early familial dilated cardiomyopathy: Identification with determination of disease state parameter from cine MR image data

Koikkalainen JR, Antila M, Lötjönen JMP, Heliö T, Lauerma K, Kivistö SM, Sipola P, Kaartinen MA, Kärkkäinen STJ, Reissell E, Kuusisto J, Laakso M, Oresic M, Nieminen MS, Peuhkurinen KJ. 2008. Radiology. 249: 88-96

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

Zeggini E, Scott LJ, Saxena R, Voight BF, for the Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Laakso M, Kuusisto J. 2008. Nature genetics. 40: 638-645

Significance of plasma levels of N-Terminal pro-B-type natriuretic peptide on left ventricular remodeling in non-obstructive hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene

Magga J, Sipola P, Vuolteenaho O, Risteli J, Jääskeläinen P, Peuhkurinen K, Kuusisto J. 2008. American journal of cardiology. 101: 1185-1190

Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance

Stancáková A, Pihlajamäki J, Kuusisto J, Stefan N, Fritsche A, Häring H, Andreozzi F, Succurro E, Sesti G, Boesgaard TW, Hansen T, Pedersen O, Jansson PA, Hammarstedt A, Smith U, Laakso M, for the EUGENE2 Consortium. 2008. Journal of clinical endocrinology and metabolism. 93: 1924-1930

The metabolic syndrome predicts incident stroke: a 14-year follow-up study in elderly people in Finland

Wang J, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M, Kuusisto J. 2008. Stroke. 39: 1078-1083

Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, AND METSIM studies

Friedrich B, Weyrich P, Stancakova A, Wang J, Kuusisto J, Laakso M, Sesti G, Succurro E, Smith U, Hansen T, Pedersen O, Machicao F, Schäfer S, Lang F, Risler T, Ullrich S, Stefan N, Fritsche A, Häring H-U. 2008. PLoS ONE. 3: e3506

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels

Chen W-M, Erdos MR, Jackson AU..., Kuusisto J, Ebrahim S..., Laakso M. 2008. Journal of clinical investigation. 118: 2620-2628

WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels

Lee JC, Weissglas-Volkov D, Kyttäjä M, Dastani Z, Cantor RM, Sobel EM, Plaisier CL, Engert JC, van Greenvenbroek MMJ, Kane JP, Malloy MJ..., Kuusisto J, Laakso M, Taskinen M-R, Genest J, Pajukanta P. 2008. American journal of human genetics. 83: 180-192

Atherosclerosis and cardiovascular risk reduction with PPAR agonists

Kuusisto J, Andrulionyte L, Laakso M, Laakso M. 2007. Current atherosclerosis reports. 9: 274-280

Cerebrovascular disease in type 2 diabetes

Laakso M, Kuusisto J. Teoksessa: Grepaldi G, Tiengo A, Avogaro A(toim.) , 2007. The Metabolic Syndrome: The Road Map from Inflammation to Cardiovascular Disease. Proceedings ot the 9th European Symposium on Metabolism. s. 65-69.

Metabolic syndrome and incident end-stage peripheral vascular disease. A 14-year follow-up study in elderly Finns

Wang J, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M, Kuusisto J. 2007. Diabetes care. 30: 3099-3104

Myocardial perfusion, oxidative metabolism, and free fatty acid uptake in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene: a positron emission tomography study

Tuunanen H, Kuusisto J, Toikka J, Jääskeläinen P, Marjamäki P, Peuhkurinen K, Viljanen T, Sipola P, Stolen KQ, Hannukainen J, Nuutila P, Laakso M, Knuuti J, Laakso M. 2007. Journal of nuclear cardiology. 14: 354-365

Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans

Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Kuusisto J, Laakso M. 2007. Obesity. 15: 2902-2907

The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns

Wang J, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M, Kuusisto J. 2007. European heart journal. 28: 857-864

Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion

Wang J, Kuusisto J, Vänttinen M, Kuulasmaa T, Lindström J, Tuomilehto J, Uusitupa M, Laakso M, Laakso M. 2007. Diabetologia. 50: 1192-1200

Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzhimer¿s disease in the Finnish population

Koivisto AM, Helisalmi S, Pihlajamäki J, Hiltunen M, Koivisto K, Moilanen L, Kuusisto J, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso M, Soininen H, Koivisto AM, Helisalmi S, Hiltunen M, Soininen H, Laakso M. 2006. Dementia and geriatric cognitive disorders. 22: 449-453

Association of metabolic syndrome with Alzheimer disease: a population-based study

Vanhanen M, Koivisto K, Moilanen L, Helkala E-L, Hänninen T, Soininen H, Kervinen K, Kesäniemi YA, Laakso M, Kuusisto J, Soininen H. 2006. Neurology. 67: 843-847

Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes

Pihlajamäki J, Salmenniemi U, Vänttinen M, Ruotsalainen E, Kuusisto J, Vauhkonen I, Kainulainen S, Ng MCY, Cox NJ, Bell CI, Laakso M, Laakso M. 2006. Diabetologia. 49: 1560-1566

Diastolic dysfunction without left ventricular hypertrophy is an early finding in children with hypertrophic cardiomyopathy-causing mutations in the beeta-myosin heavy chain, alfa-tropomyosin, and myosin-binding protein C genes

Poutanen T, Tikanoja T, Jääskeläinen P, Jokinen E, Silvast A, Laakso M, Kuusisto J, Laakso M. 2006. American heart journal. 151: 725.e1-725.e9

Myocardial late gadolinium enhancement is associated with raised serum amino-terminal propeptide of type III collagen concentrations in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha tropomyosin gene:

Sipola P, Peuhkurinen K, Lauerma K, Husso M, Jääskeläinen P, Laakso M, Aronen HJ, Risteli J, Kuusisto J, Laakso M. 2006. Heart

Novel mutations in the lamin A/C gene in heart transplant recipients with end stage dilated cardiomyopathy

Kärkkäinen S, Reissell E, Heliö T, Kaartinen M, Tuomainen P, Toivonen L, Kuusisto J, Kupari M, Nieminen MS, Laakso M, Peuhkurinen K, Laakso M. 2006. Heart. 92: 524-526

Atherosclerosis-like lesions of the aortic valve are common in adults of all ages: a necropsy study

Kuusisto J, Räsänen K, Särkioja T, Alarakkola E, Kosma V-M. 2005. Heart. 91: 576-582

Cine MR imaging of myocardial contractile impairment in patients with hypertrophic cardiomyopathy attributable to Asp175Asn mutation in the alpha-tropomyosin gene

Sipola P, Lauerma K, Jääskeläinen P, Laakso M, Peuhkurinen K, Manninen H, Aronen HJ, Kuusisto J, Laakso M. 2005. Radiology. 236: 815- 824

Insulin resistance and coronary heart disease

Laakso M, Kuusisto J. Teoksessa: Serrano Ríos M, Caro JF, Carraro R, Gutiérrez Fuentes JA(toim.) , 2005. The Metabolic Syndrome at the Beginning of the XXIst Century. s. 369-382. Elsevier

Sydämen vajaatoiminta - monimuotoinen haaste

Kuusisto J. 2005. Lääkärilehti

A novel mutation, Ser143Pro, in the lamin A/C gene is common in finnish patients with familial dilated cardiomyopathy

Kärkkäinen S, Heliö T, Miettinen R, Tuomainen P, Peltola P, Rummukainen J, Ylitalo K, Kaartinen M, Kuusisto J, Toivonen L, Nieminen MS, Laakso M, Peuhkurinen K, Laakso M. 2004. European heart journal. 25: 885-893

Genetics of hypertrophic cardiomyopathy in eastern Finland: few founder mutations with benign or intermediary phenotypes

Jääskeläinen P, Miettinen R, Kärkkäinen P, Toivonen L, Laakso M, Kuusisto J. 2004. Annals of medicine. 36: 23-32

Inducibility of life-threatening ventricular arrhythmias is related to maximum left ventricular thickness and clinical markers of sudden cardiac death in patients with hypertrophic cardiomyopathy attridutable to the Asp175Asn mutation in the Alfa-tropomyo

Hedman A, Hartikainen J, Vanninen E, Laitinen T, Jääskeläinen P, Laakso M, Peuhkurinen K, Kuusisto J, Laakso M. 2004. Journal of molecular and cellular cardiology. 36: 91-99

The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain

Rutanen J, Pihlajamäki J, Karhapää P, Vauhkonen I, Kuusisto J, Moilanen Mykkänen L, Laakso M, Laakso M. 2004. Obesity. 12: 1060-1066

Two novel mutations in the beta-myosin heavy chain gene associated with dilated cardiomyopathy

Kärkkäinen S, Heliö T, Jääskeläinen P, Miettinen R, Tuomainen P, Ylitalo K, Kaartinen M, Reissell E, Toivonen L, Nieminen MS, Kuusisto J, Laakso M, Peuhkurinen K. 2004. European journal of heart failure. 6: 861-868

A novel mutation, Arg71Thr, in the delta-sarcoglycan gene is associated with dilated cardiomyopathy

Kärkkäinen S, Miettinen R, Tuomainen P, Kärkkäinen P, Heliö T, Reissell E, Kaartinen M, Toivonen L, Nieminen MS, Kuusisto J, Laakso M, Peuhkurinen K, Laakso M. 2003. Journal of molecular medicine: jmm. 81: 795-800

Cardiac adrenergic activity is associated with left ventricular hypertrophy in genetically homogenous subjects with hypertrophic cardiomyopathy

Sipola P, Vanninen E, Aronen HJ, Lauerma K, Simula S, Jääskeläinen P, Laakso M, Peuhkurinen K, Kuusisto J, Kuikka JT, Laakso M. 2003. Journal of nuclear medicine. 44: 487-493

First-pass MR imaging in the assessment of perfusion impairment in patients with hypertrophic cardiomyopathy and the asp 175asn mutation of the alfa-tropomyosin gene

Sipola P, Lauerma K, Husso-Saastamoinen M, Kuikka JT, Vanninen E, Laitinen T, Manninen H, Niemi P, Peuhkurinen K, Jääskeläinen P, Laakso M, Kuusisto J, Aronen HJ, Laakso M. 2003. Radiology. 226: 129-137

Understanding patient needs. Diabetology for cardiologists

Laakso M, Kuusisto J. 2003. European heart journal supplements. 5 (Suppl B): B5-B13

Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland

Jääskeläinen P, Kuusisto J, Miettinen R, Kärkkäinen P, Kärkkäinen S, Heikkinen S, Peltola P, Pihlajamäki J, Vauhkonen I, Laakso M. 2002. Journal of molecular medicine: jmm. 80: 412-422

No variants in the cardiac actin gene in Finnish patients with dilated or hypertrophic cardiomyopathy

Kärkkäinen S, Peuhkurinen K, Jääskeläinen P, Miettinen R, Kärkkäinen P, Kuusisto J, Laakso M. 2002. American heart journal. 143: 11-14

APOE-epsilon4 is associated with weight loss in women with AD. A population-based study

Vanhanen M, Kivipelto M, Koivisto K, Kuusisto J, Mykkänen L, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso MP, Soininen H, Laakso M. 2001. Neurology. 56: 655-659

Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men

Kuusisto J, Lempiäinen P, Mykkänen L, Laakso M. 2001. Diabetes care. 24: 1629-1633

New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes

Wang H, Rissanen J, Miettinen R, Kärkkäinen P, Kekäläinen P, Kuusisto J, Mykkänen L, Karhapää P, Laakso M. 2001. Diabetes. 50: 1949-1951

Apolipoprotein E phenotype alone does not influence survival in Alzheimer's disease: a population-based longitudinal study

Koivisto AM, Lempiäinen P, Koivisto K, Helkala E-L, Mykkänen L, Kuusisto J, Kervinen K, Kesäniemi YA, Laakso M, Soininen H. 2000. Neuroepidemiology. 19: 327-332

Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase. Cloning, genomic structure, and screening for variants in patients with type 2 diabetes

Kossila M, Sinkovic M, Kärkkäinen P, Laukkanen MO, Miettinen R, Rissanen J, Kekäläinen P, Kuusisto J, Ylä-Herttuala S, Laakso M. 2000. Diabetes. 49: 1740-1743

Hypertrofinen kardiomyopatia

Kuusisto J. Teoksessa: Heikkilä J, Huikuri H, Luomanmäki K, Nieminen MS, Peuhkurinen K(toim.) , 2000. Kardiologia. s. 853-865. Duodecim

Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin

Rissanen J, Markkanen A, Kärkkäinen P, Pihlajamäki J, Kekäläinen P, Mykkänen L, Kuusisto J, Karhapää P, Niskanen L, Laakso M. 2000. Diabetes care. 23: 70-73

The Pro12Ala substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with d

Pihlajamäki J, Miettinen R, Valve R, Karjalainen L, Mykkänen L, Kuusisto J, Deeb S, Auwerx J, Laakso M. 2000. Atherosclerosis. 151: 567-574

Variants in the hepatocyte nuclear factor-1alfa and -4alfa genes in Finnish and Chinese subjects with late-onset type 2 diabetes

Rissanen J, Wang H, Miettinen R, Kärkkäinen P, Kekäläinen P, Mykkänen L, Kuusisto J, Karhapää P, Niskanen L, Uusitupa M, Laakso M. 2000. Diabetes care. 23: 1533-1538

Insulin resistance syndrome and Alzheimer's disease: the summary of Finnish studies

Kuusisto J, Koivisto K, Mykkänen L, Helkala E, Vanhanen M, Hänninen T, Kervinen K, Kesäniemi YA, Riekkinen P, Laakso M. Teoksessa: Vellas B, Fitten LJ(toim.) , 1999. Research and Practice in Alzheimer's Disease. s. 135-139. Serdi Publisher

Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men

Lempiäinen P, Mykkänen L, Pyörälä K, Laakso M, Kuusisto J. 1999. Circulation. 100: 123-128

LDL size and risk of coronary heart disease in elderly men and women

Mykkänen L, Kuusisto J, Haffner SM, Laakso M, Austin MA. 1999. Arteriosclerosis, thrombosis, and vascular biology. 19: 2742-2748

Prandial glucose regulation and cardiovascular disease in Type 2 diabetes

Kuusisto J, Laakso M. 1999. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. SUPPLEMENT. 29: 7-11

Sarkomeerin geenimutaatiot - hypertrofisen kardiomyopatian syy

Kuusisto J, Jääskeläinen P, Laakso M. 1999. Duodecim

Simultaneous hypertrophic cardiomyopathy and ventricular septal defect in children

Tikanoja T, Jääskeläinen P, Laakso M, Kuusisto J. 1999. American journal of cardiology. 84: 485-486

The cardiac troponin I gene is not associated with hypertrophic cardiomyopathy in patients from Eastern Finland

Jääskeläinen P, Miettinen R, Silvennoinen K, Vauhkonen I, Laakso M, Kuusisto J. 1999. Journal of molecular and cellular cardiology. 31: 2031-2036

Type-2 diabetes and cognitive function in a non-demented population

Vanhanen M, Kuusisto J, Koivisto K, Mykkänen L, Helkala E-L, Hänninen T, Riekkinen P Sr, Soininen H, Laakso M. 1999. Acta neurologica scandinavica. 100: 97-101

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

Deeb SS, Fajas L, Nemoto M, Pihlajamäki J, Mykkänen L, Kuusisto J, Laakso M, Fujimoto W, Auwerx J. 1998. Nature genetics

Can degenerative aortic valve stenosis be related to persistent Chlamydia pneumoniae infection?

Juvonen J, Juvonen T, Laurila A, Kuusisto J, Alarakkola E, Särkioja T, Bodian CA, Kairaluoma MI, Saikku P. 1998. Annals of internal medicine. 128: 741-744

Cognitive function in an elderly population with persistent impaired glucose tolerance

Vanhanen M, Koivisto K, Kuusisto J, Mykkänen L, Helkala E-L, Hänninen T, Riekkinen P Sr, Soininen H, Laakso M. 1998. Diabetes care. 21: 398-402

Glucokinase gene islet promoter region variant (G->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns

Rissanen J, Saarinen L, Heikkinen S, Kekäläinen P, Mykkänen L, Kuusisto J, Deeb SS, Laakso M. 1998. Diabetes care. 21: 1194-1197

The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population

Jääskeläinen P, Soranta M, Miettinen R, Saarinen L, Pihlajamäki J, Silvennoinen K, Tikanoja T, Laakso M, Kuusisto J. 1998. Journal of the american college of cardiology. 32: 1709-1716

Aorttaläppästenoosin patogeneesi selviämässä

Kuusisto J. 1997. Duodecim

Association between features of the insulin resistance syndrome and Alzheimer`s disease independently of apolipoprotein E4 phenotype:cross sectional population based study

Kuusisto J, Koivisto K, Mykkänen L, Helkala E-L, Vanhanen M, Hänninen T, Kervinen K, Kesäniemi YA, Riekkinen PJ, Laakso M. 1997. BMJ international edition. 315: 1045-1049

Detection of Chlamydia pneumoniae in human nonrheumatic stenotic aortic valves

Juvonen J, Laurila A, Juvonen T, Alakärppä H, Surcel H-M, Lounatmaa K, Kuusisto J, Saikku P. 1997. Journal of the american college of cardiology. 29: 1054-1059

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease

Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, Van Duijn CM, for the APOE and Alzheimer Disease Meta Analysis Consorium, Koivisto K, Lehtovirta M, Riekkinen P Sr, Kuusisto J, Laakso M, Soininen H. 1997. JAMA : Journal of the American Medical Association. 278: 1349-1356

New variants in the glycogen synthase gene (GIn71His, Met416Val) in patients with NIDDM from eastern Finland

Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Mykkänen L, Kuusisto J, Kolle A, Laakso M. 1997. Diabetologia. 40: 1313-1319

Stability of age-associated memory impairment during a longitudinal population-based study

Helkala E-L, Koivisto K, Hanninen T, Vanhanen M, Kuusisto J, Mykkanen L, Laakso M, Riekkinen P Sr. 1997. Journal of the american geriatrics society

The ala54thr polymorphism of the fatty acid binding protein 2 gene does not influence insulin sensitivity in Finnish nondiabetic and NIDDM subjects

Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Kuusisto J, Laakso M. 1997. Diabetes. 46: 711-712

The trp64arg polymorphism of the beta3-adrenergic receptor gene

Rissanen J, Kuopusjärvi M, Pihlajamäki J, Sipiläinen R, Heikkinen S, Vanhala M, Kekäläinen P, Kuusisto J, Laakso M. 1997. Diabetes care. 20: 1319-1323

Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of 'degenerative' valvular aortic stenosis

O'Brien KD, Reichenbach DD, Marcovina SM, Kuusisto J, Alpers CE, Otto CM. 1996. Arteriosclerosis, thrombosis, and vascular biology. 16: 523-532

Epidemiological evidence for the association of hyperglycaemia and atheroslecrotic vascular disease in non-insulin-dependent diabetes mellitus

Laakso M, Kuusisto J. 1996. Annals of medicine. 28: 415-418

Gender differences in left ventricular function at rest and with exercise in asymptomatic aortic stenosis

Legget ME, Kuusisto J, Healy NL, Fujioka M, Schwaegler RG, Otto CM. 1996. American heart journal. 131: 94-100

Hyperglykemia lisää sydän- ja verisuonitauteihin sairastuvuutta aikuistyypin diabeteksessa

Kuusisto J, Lehto S, Laakso M. 1996. Duodecim. 112: 1965-1966

Memory functions in human subjects with different apolipoprotein E phenotypes during a 3-year population-based follow-up study

Helkala E-L, Koivisto K, Hänninen T, Vanhanen M, Kervinen K, Kuusisto J, Mykkänen L, Kesäniemi YA, Laakso M, Riekkinen P Sr. 1996. Neuroscience letters. 204: 177-180

Retroperitoneal fibrosis with antineutrophil cytoplasmic antibodies

Kaipiainen-Seppänen O, Jantunen E, Kuusisto J, Marin S. 1996. Journal of rheumatology. 23: 779-781

Risk Factors for Non-Insulin-Dependent Diabetes, Coronary Heart Disease and Stroke in Elderly Subjects

Kuusisto J. 1996. Kuopio University Publications D. Medical Sciences

Apolipoprotein E4 phenotype is not an important risk factor for coronary heart disease or stroke in elderly subjects

Kuusisto J, Mykkänen L, Kervinen K, Kesäniemi YA, Laakso M. 1995. Arteriosclerosis, thrombosis, and vascular biology. 15: 1280-1286

Glucokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance

Laakso M, Malkki M, Kekäläinen P, Kuusisto J, Mykkänen L, Deeb SS. 1995. Diabetes care. 18: 398-400

Hyperinsulinemic microalbuminuria: A new risk indicator for coronary heart disease

Kuusisto J, Mykkänen L, Pyörälä K, Laakso M. 1995. Circulation. 91: 831-837

Improvement of metabolic control does not normalize auditory brainstem latencies in subjects with insulin-dependent diabetes mellitus

Virtaniemi J, Kuusisto J, Karjalainen L, Karjalainen S, Laakso M. 1995. American journal of otolaryngology. 16: 172-176

Osteopontin is expressed in human aortic valvular lesions

O'Brien KD, Kuusisto J, Reichenbach DD, Ferguson M, Giachelli C, Alpers CE, Otto CM. 1995. Circulation. 92: 2163-2168

Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance

Laakso M, Malkki M, Kekäläinen P, Kuusisto J, Deeb SS. 1995. Diabetologia. 38: 617-622

Prospective study of small LDLs as a risk factor for non-insulin dependent diabetes mellitus in elderly men and women

Austin MA, Mykkänen L, Kuusisto J, Edwards KL, Nelson C, Haffner SM, Pyörälä K, Laakso M. 1995. Circulation. 92: 1770-1778

Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects

Mykkänen L, Haffner SM, Kuusisto J, Pyörälä K, Hales CN, Laakso M. 1995. Diabetologia. 38: 1176-1182

The association of apolipoprotein E polymorphism with memory: a population based study

Helkala E-L, Koivisto K, Hänninen T, Vanhanen M, Kervinen K, Kuusisto J, Mykkänen L, Kesäniemi YA, Laakso M, Riekkinen P Sr. 1995. Neuroscience letters. 191: 141-144

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Research groups

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Cell-type composition affects adipose gene expression associations with cardiometabolic traits

Late-onset and classic phenotypes of Fabry disease in males with the GLA-Thr410Ala mutation

SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Effects of age, amyloid, sex, and APOE epsilon 4 on the CSF proteome in normal cognition

Genetic diversity fuels gene discovery for tobacco and alcohol use

Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies.

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci

Healthcare resource use of patients with transthyretin amyloid cardiomyopathy

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Multiparametric platform for profiling lipid trafficking in human leukocytes

Prevalence, characteristics, and mortality of patients with transthyretin amyloid cardiomyopathy in the Nordic countries

Subcutaneous adipose tissue splice quantitative trait loci reveal differences in isoform usage associated with cardiometabolic traits

Uudet dyslipidemialääkkeet

Association of structural variation with cardiometabolic traits in Finns

Cardiac Involvement in Fabry Disease

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

Machine Learning Reveals Time-Varying Microbial Predictors with Complex Effects on Glucose Regulation

Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids

Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences

Nationwide prevalence and characteristics of transthyretin amyloid cardiomyopathy in Sweden

Rare coding variants in 35 genes associate with circulating lipid levels - A multi-ancestry analysis of 170,000 exomes

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

The association of nine amino acids with cardiovascular events in Finnish men in a 12-year follow-up study

The power of genetic diversity in genome-wide association studies of lipids

The trans-ancestral genomic architecture of glycemic traits

Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences

Cardiomyopathy associated with the Ala143Thr variant of the α-galactosidase A gene

Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer's disease

Genetics of hypertrophic cardiomyopathy: what is the next step?

Novel biomarkers associated with incident heart failure in 10 106 Finnish men

Rotation and torsion of the left ventricle with cardiovascular magnetic resonance tagging: comparison of two analysis methods

A catalog of genetic loci associated with kidney function from analyses of a million individuals

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits

Associations of autozygosity with a broad range of human phenotypes

CMR derived left ventricular septal convexity in carriers of the hypertrophic cardiomyopathy-causing MYBPC3-Q1061X mutation

Circulating RNAs as predictive markers for the progression of type 2 diabetes

Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution

Disentangling the genetics of lean mass

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

Fabry-kardiomyopatia

Genetic basis and outcome in a nationwide study of Finnish patients with hypertrophic cardiomyopathy

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

Nine Amino Acids are Associated with Decreased Insulin Secretion and Elevated Glucose Levels in a 4.6-Year Follow-Up Study of 5,181 Finnish Men

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study

Akuuttia sisämedisiinaa tarvitaan

Decreased plasma C-reactive protein levels in APOE E 4 allele carriers

Epigenome-wide association in adipose tissue from the METSIM cohort

Fibrosis and wall thickness affect ventricular repolarization dynamics in hypertrophic cardiomyopathy

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia

Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease

Genetiikka

Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study

Novel electrocardiographic features in carriers of hypertrophic cardiomyopathy causing sarcomeric mutations

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling

Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans

A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the Adcy5 Locus

Clinical disease presentation and ECG characteristics of LMNA mutation carriers

Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study

Decreased plasma ß-amyloid in the Alzheimer's disease APP A673T variant carriers

Diabetes secondary to treatment with statins

Differential Associations of Inflammatory Markers With Insulin Sensitivity and Secretion: The Prospective METSIM Study