JORMA PALVIMO
Professor
Director of the Master´s Degree Programme in Biomedicine
Vice Dean, Faculty of Health Sciences
Our research builds on our firm expertise in the steroid signaling and transcriptional regulation and our pioneering work on the SUMOylation of transcription factors and chromatin. Our current major goals are to:
- Identify the chromatin-bound proteins associated with the androgen receptor (AR) and the glucocorticoid receptor (GR) and reveal the role of SUMOylation in these associations.
- Discover novel means to target the AR and GR in castration resistant prostate cancer.
- Reveal the chromatin targets and mechanisms by which SUMOylation regulates gene networks and chromatin structure in cellular plasticity.
To address these aims, we will use cutting-edge genome- and proteome-wide tools, including GRO-seq, ChIP-seq, ChIP-SICAP and Turbo-ID proximity labeling, with human prostate cancer cell lines, mesenchymal stem cells and reprogrammable somatic cells as our main model systems.
We anticipate that our systemic studies and studies will provide us with novel leads for targeting steroid receptors. We also believe that our innovative and systematic approaches with multitalented research collaboration will provide us with novel SUMOylation targets and significant discoveries of the mechanisms by which SUMOylation regulates cellular plasticity and homeostasis. The results are likely to have translational potential in regenerative medicine and drug discovery for diseases, such as cancer.
Contact info
Organization
School of Medicine, Biomedicine
Keywords
Publications
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Lempiäinen, JK; Manjur, ABMK; Malinen, M; Ketola, K; Niskanen, EA; Palvimo, JJ. 2020. BCOR-coupled H2A monoubiquitination represses a subset of androgen receptor target genes regulating prostate cancer proliferation Oncogene 39: 2391-2407. 2020
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Jaillard, Sylvie; Bell, Katrina; Akloul, Linda; Walton, Kelly; McElreavy, Kenneth; Stocker, William A; Beaumont, Marion; Harrisson, Craig; Jääskeläinen, Tiina; Palvimo, Jorma J; Robevska, Gorjana; Launay, Erika; Satié, Anne-Pascale; Listyasari, Nurin; Bendavid, Claude; Sreenivasan, Rajini; Duros, Solène; van den Bergen, Jocelyn; Henry, Catherine; Domin-Bernhard, Mathilde et al.. 2020. New insights into the genetic basis of premature ovarian insufficiency: novel causative variants and candidate genes revealed by genomic sequencing Maturitas 141: 9-19. 2020
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Dendoncker, K; Timmermans, S; Vandewalle, J; Eggermont, M; Lempiäinen, J; Van Hamme, E; Dewaele, S; Vandevyver, S; Ballegeer, M; Souffriau, J; Van Wyngene, L; Van Looveren, K; Vanderhaeghen, T; Beyaert, R; De Bosscher, K; Palvimo, JJ; Van Montagu, M; Libert, C. 2019. TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile Proceedings of the National Academy of Sciences of the United States of America 116 26: 12942-12951. 2019
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Kaiser Manjur, ABM; Lempiäinen, Joanna K; Malinen, Marjo; Palvimo, Jorma J; Niskanen, Einari A. 2019. IRF2BP2 Modulates the Crosstalk between Glucocorticoid and TNF Signaling Journal of steroid biochemistry and molecular biology 192: 105382. 2019
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Tolonen, JP; Heikkilä, M; Malinen, M; Lee, HM; Palvimo, JJ; Wei, GH; Myllyharju, J. 2019. A long hypoxia-inducible factor 3 isoform 2 is a transcription activator that regulates erythropoietin Cellular and molecular life sciences [First Online 25 November 2019]: 1-16. 2019
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Zhang, Fu-Ping; Malinen, Marjo; Mehmood, Arfa; Lehtiniemi, Tiina; Jääskeläinen, Tiina; Niskanen, Einari A; Korhonen, Hanna; Laiho, Asta; Elo, Laura L; Ohlsson, Claes; Kotaja, Noora; Poutanen, Matti; Sipilä, Petra; Palvimo, Jorma J. 2019. Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction Nature communications 10: 777. 2019
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Lempiäinen Joanna K, Niskanen Einari A, Vuoti Kaisa-Mari, Lampinen Riikka E, Göös Helka, Varjosalo Markku, Palvimo Jorma J. 2017. Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping. Molecular & Cellular Proteomics 16 8: 1462-1474. 2017
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Malinen Marjo, Niskanen Einari A, Kaikkonen Minna U, Palvimo Jorma J. 2016. Crosstalk between androgen and pro-inflammatory signaling remodels androgen receptor and NF-kB cistrome to reprogram the prostate cancer cell transcriptome. NUCLEIC ACIDS RESEARCH 45 2: 619-630. 2016
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Niskanen Einari A, Malinen Marjo, Sutinen Päivi, Toropainen Sari, Paakinaho Ville, Vihervaara Anniina, Joutsen Jenny, Kaikkonen Minna U, Sistonen Lea, Palvimo Jorma J. 2015. Global SUMOylation on active chromatin is an acute heat stress response restricting transcription Genome biology 16: 153. 2015
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Eisenhardt Nathalie, Chaugule Viduth K, Koidl Stefanie, Droescher Mathias, Dogan Esen, Rettich Jan, Sutinen Päivi, Imanishi Susumu Y, Hofmann Kay, Palvimo Jorma J, Pichler Andrea. 2015. A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly. Nature Structural & Molecular Biology 22: 959-967. 2015