
JORMA PALVIMO
Professor
Professor
Professor of Medical Biochemistry
Director of the Master´s Degree Programme in Biomedicine
Our research builds on our firm expertise in the steroid signaling and transcriptional regulation and our pioneering work on the SUMOylation of transcription factors and chromatin. Our current major goals are to:
- Identify the chromatin-bound proteins associated with the androgen receptor (AR) and the glucocorticoid receptor (GR) and reveal the role of SUMOylation in these associations.
- Discover novel means to target the AR and GR in castration resistant prostate cancer.
- Reveal the chromatin targets and mechanisms by which SUMOylation regulates gene networks and chromatin structure in cellular plasticity.
To address these aims, we will use cutting-edge genome- and proteome-wide tools, including GRO-seq, ChIP-seq, ChIP-SICAP and Turbo-ID proximity labeling, with human prostate cancer cell lines, mesenchymal stem cells and reprogrammable somatic cells as our main model systems.
We anticipate that our systemic studies and studies will provide us with novel leads for targeting steroid receptors. We also believe that our innovative and systematic approaches with multitalented research collaboration will provide us with novel SUMOylation targets and significant discoveries of the mechanisms by which SUMOylation regulates cellular plasticity and homeostasis. The results are likely to have translational potential in regenerative medicine and drug discovery for diseases, such as cancer.
Contact info
Organization
School of Medicine, Biomedicine
jorma.palvimo@uef.fi
Phone
+358 40 591 0693
Keywords
Teaching Activities
Endocrinology, molecular biology, biomedical research and research planning
Research groups - UEF
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EDCMET
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Steroid Receptor Research Center
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Steroid Receptors and SUMO Modifications in the Regulation of Gene Networks and Cellular Plasticity
Links
Publications
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Antonio Urrutia, Gustavo; Ramachandran, Haribaskar; Cauchy, Pierre; Boo, Kyungjin; Ramamoorthy, Senthilkumar; Boller, Soeren; Dogan, Esen; Clapes, Thomas; Trompouki, Eirini; Torres-Padilla, Maria-Elena; Palvimo, Jorma J.; Pichler, Andrea; Grosschedl, Rudolf. 2021. ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell differentiation Genes and development 35 15-16: 1142-1160. 2021
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Launonen, Kaisa-Mari; Paakinaho, Ville; Sigismondo, Gianluca; Malinen, Marjo; Sironen, Reijo; Hartikainen, Jaana M; Laakso, Hanna; Visakorpi, Tapio; Krijgsveld, Jeroen; Niskanen, Einari A; Palvimo, Jorma J. 2021. Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells Oncogene 40 27: 4567-4579. 2021
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Manjur, ABMK; Lempiäinen, JK; Malinen, M; Varjosalo, M; Palvimo, JJ; Niskanen, EA. 2021. BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility Journal of steroid biochemistry and molecular biology 210: 105873. 2021
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Paakinaho, Ville; Lempiäinen, Joanna K; Sigismondo, Gianluca; Niskanen, Einari A; Malinen, Marjo; Jääskeläinen, Tiina; Varjosalo, Markku; Krijgsveld, Jeroen; Palvimo, Jorma J. 2021. SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites Nucleic acids research 49 4: 1951-1971. 2021
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Paakinaho, Ville; Palvimo, Jorma J. 2021. Genome-wide crosstalk between steroid receptors in breast and prostate cancers Endocrine-related cancer 28 9: R231-R250. 2021
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Rawat, Prashant; Boehning, Marc; Hummel, Barbara; Aprile-Garcia, Fernando; Pandit, Anwit S; Eisenhardt, Nathalie; Khavaran, Ashkan; Niskanen, Einari; Vos, Seychelle M; Palvimo, Jorma J; Pichler, Andrea; Cramer, Patrick; Sawarkar, Ritwick. 2021. Stress-induced nuclear condensation of NELF drives transcriptional downregulation Molecular cell 81 5: 1013-1026. 2021
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Vanderhaeghen, Tineke; Timmermans, Steven; Watts, Deepika; Paakinaho, Ville; Eggermont, Melanie; Vandewalle, Jolien; Wallaeys, Charlotte; Van Wyngene, Lise; Van Looveren, Kelly; Nuyttens, Louise; Dewaele, Sylviane; Vanden Berghe, Joke; Lemeire, Kelly; De Backer, Joey; Dirkx, Laura; Vanden Berghe, Wim; Caljon, Guy; Ghesquière, Bart; De Bosscher, Karolien; Wielockx, Ben et al [incl. Palvimo, Jorma J. 2021. Reprogramming of glucocorticoid receptor function by hypoxia Embo reports 2022; 23 1: e53083. 2021
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Vandewalle, Jolien; Timmermans, Steven; Paakinaho, Ville; Vancraeynest, Lies; Dewyse, Liza; Vanderhaeghen, Tineke; Wallaeys, Charlotte; Van Wyngene, Lise; Van Looveren, Kelly; Nuyttens, Louise; Eggermont, Melanie; Dewaele, Sylviane; Velho, Tiago R; Moita, Luis F; Weis, Sebastian; Sponholz, Christoph; van Grunsven, Leo A; Dewerchin, Mieke; Carmeliet, Peter; De Bosscher, Karolien; et al.; [incl. Pal. 2021. Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis Cell metabolism 33 9: 1763-1776.e5. 2021
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El Kharraz, Sarah; Dubois, Vanessa; Royen, Martin E; Houtsmuller, Adriaan B; Pavlova, Ekatarina; Atanassova, Nina; Nguyen, Tien; Voet, Arnout; Eerlings, Roy; Handle, Florian; Prekovic, Stefan; Smeets, Elien; Moris, Lisa; Devlies, Wout; Ohlsson, Claes; Poutanen, Matti; Verstrepen, Kevin J; Carmeliet, Geert; Launonen, Kaisa-Mari; Helminen, Laura et al [incl. Palvimo, Jorma J]. 2021. The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation Embo reports 22 12: e52764. 2021
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Jaillard, Sylvie; Bell, Katrina; Akloul, Linda; Walton, Kelly; McElreavy, Kenneth; Stocker, William A; Beaumont, Marion; Harrisson, Craig; Jääskeläinen, Tiina; Palvimo, Jorma J; Robevska, Gorjana; Launay, Erika; Satié, Anne-Pascale; Listyasari, Nurin; Bendavid, Claude; Sreenivasan, Rajini; Duros, Solène; van den Bergen, Jocelyn; Henry, Catherine; Domin-Bernhard, Mathilde et al.. 2020. New insights into the genetic basis of premature ovarian insufficiency: novel causative variants and candidate genes revealed by genomic sequencing Maturitas 141: 9-19. 2020