Juha Hyttinen

Non-Coding RNAs Regulating Mitochondrial Functions and the Oxidative Stress Response as Putative Targets against Age-Related Macular Degeneration (AMD)

Hyttinen, Juha MT; Blasiak, Janusz; Kaarniranta, Kai. 2023. International journal of molecular sciences. 24:

Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice

Blasiak, Janusz; Koskela, Ali; Pawlowska, Elzbieta; Liukkonen, Mikko; Ruuth, Johanna; Toropainen, Elisa; Hyttinen, Juha MT; Viiri, Johanna; Eriksson, John E.; Xu, Heping; Chen, Mei; Felszeghy, Szabolcs; Kaarniranta, Kai. 2021. International journal of molecular sciences. 22: 1684

MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy

Hyttinen, Juha M T; Blasiak, Janusz; Felszeghy, Szabolcs; Kaarniranta, Kai. 2021. Ageing research reviews. 67: 101260

Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3

Sridevi Gurubaran, Iswariyaraja; Heloterä, Hanna; Marry, Stephen; Koskela, Ali; Hyttinen, Juha MT; Paterno, Jussi J; Urtti, Arto; Chen, Mei; Xu, Heping; Kauppinen, Anu; Kaarniranta, Kai. 2021. Biology. 10: 622

Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice

Tamminen, Toni; Koskela, Ali; Toropainen, Elisa; Gurubaran, Iswariyaraja Sridevi; Winiarczyk, Mateusz; Liukkonen, Mikko; Paterno, Jussi J; Lackman, Petri; Sadeghi, Amir; Viiri, Johanna; Hyttinen, Juha MT; Koskelainen, Ari; Kaarniranta, Kai. 2021. Oxidative medicine and cellular longevity. 2021:

Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration

Blasiak, Janusz; Hyttinen, Juha M. T.; Szczepanska, Joanna; Pawlowska, Elzbieta; Kaarniranta, Kai. 2021. International journal of molecular sciences. 22: 9178

Therapeutic potential of PGC-1α in age-related macular degeneration (AMD) - the involvement of mitochondrial quality control, autophagy, and antioxidant response

Hyttinen, Juha; Blasiak, Janusz; Tavi, Pasi; Kaarniranta, Kai. 2021. Expert opinion on therapeutic targets. 25: 773-785

Autophagy Genes for Wet Age-Related Macular Degeneration in a Finnish Case-Control Study

Paterno, Jussi J; Koskela, Ali; Hyttinen, Juha M T; Vattulainen, Elina; Synowiec, Ewelina; Tuuminen, Raimo; Watala, Cezary; Blasiak, Janusz; Kaarniranta, Kai. 2020. Genes. 11: 1318

Only IL-1ß release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted

Korhonen, Eveliina; Piippo, Niina; Hytti, Maria; Hyttinen, Juha; Kaarniranta, Kai; Kauppinen, Anu. 2020. Faseb journal. 34: 6437-6448

UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells

Korhonen, Eveliina; Bisevac, Jovana; Hyttinen, Juha MT; Piippo, Niina; Hytti, Maria; Kaarniranta, Kai; Petrovski, Goran; Kauppinen, Anu. 2020. Investigative ophthalmology and visual science. 61: 7

Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy

Hytti, Maria; Korhonen, Eveliina; Hyttinen, Juha M T; Roehrich, Heidi; Kaarniranta, Kai; Ferrington, Deborah A; Kauppinen, Anu. 2019. Oxidative medicine and cellular longevity. 2019: 1583656

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Redox biology. 2019; 20: 1-12

Mitochondrial quality control in AMD: does mitophagy play a pivotal role?

Hyttinen, Juha MT; Viiri, Johanna; Kaarniranta, Kai; Blasiak, Janusz. 2018. Cellular and molecular life sciences. 75: 2991-3008

Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells

Juuti-Uusitalo K, Koskela A, Kivinen N, Viiri J, Hyttinen JMT, Reinisalo M, Koistinen A, Uusitalo H, Sinha D, Skottman H, Kaarniranta K. 2017. International journal of molecular sciences. 18: 1089

DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells - Implications for age-related macular degeneration (AMD)

Hyttinen JMT, Blasiak J, Niittykoski M, Kinnunen K, Kauppinen A, Salminen A, Kaarniranta K. 2017. Ageing research reviews. 36: 64-77

Hsp70 binds reversibly to proteasome inhibitor-induced protein aggregates and evades autophagic clearance in ARPE-19 cells

Kivinen Niko, Hyttinen Juha MT, Viiri Johanna, Paterno Jussi, Felszheghy Szabolcs, Kauppinen Anu, Salminen Antero, Kaarniranta Kai. 2014. Journal of biochemical and pharmacological research. 2: 1-7

Oxidative stress plays an important role in zoledronic acid-induced autophagy

Khandelwal VK, Mitrofan LM, Hyttinen JM, Chaudhari KR, Buccione R, Kaarniranta K, Ravingerová T, Mönkkönen J. 2014. Physiological research. 63: S601-S612

Pinosylvin-mediated protection against oxidative stress in human retinal pigment epithelial cells

Koskela Ali, Reinisalo Mika, Hyttinen Juha MT, Kaarniranta Kai, Karjalainen Reijo O. 2014. Molecular vision. 20: 760-769

Upregulation of inflammatory genes in the nasal mucosa of patients undergoing endonasal dacryocystorhinostomy

Penttilä E, Hyttinen JMT, Hytti M, Kauppinen A, Smirnov G, Tuomilehto H, Seppä J, Nuutinen J, Kaarniranta K. 2014. Clinical ophthalmology. 8: 799-805

Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells

Viiri J, Amadio M, Marchesi N, Hyttinen JM, Kivinen N, Sironen R, Rilla K, Akhtar S, Provenzani A, D'Agostino VG, Govoni S, Pascale A, Agostini H, Petrovski G, Salminen A, Kaarniranta K. 2013. PLoS ONE. 8: e6963, 16 pages

Hyaluronan synthase 1 (HAS1) produces a cytokine- and glucose-inducible, CD44-dependent cell surface coat

Siiskonen H, Kärnä R, Hyttinen JM, Tammi RH, Tammi MI, Rilla K. 2013. Experimental cell research. online: -

Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GIcNAc concentration than HAS2 and HAS3

Rilla K, Oikari S, Jokela TA, Hyttinen JMT, Kärnä R, Tammi RH, Tammi MI. 2013. Journal of biological chemistry. 288: 5973-5983

Maturation of autophagosomes and endosomes: A key role for Rab7

Hyttinen JMT, Niittykoski M, Salminen A, Kaarniranta K. 2013. Biochimica et biophysica acta: international journal of biochemistry and biophysics. 1833: 503-510

Context-dependent regulation of autophagy by IKK-NF-kappaB signaling: Impact on the aging process

Salminen A, Hyttinen JMT, Kauppinen A, Kaarniranta K. 2012. International journal of cell biology. 2012: 15 pages

Role of CD44 in the organization of keratinocyte pericellular hyaluronan

Pasonen-Seppänen S, Hyttinen JM, Rilla K, Jokela T, Noble PW, Tammi M, Tammi R. 2012. Histochemistry and cell biology. 137: 107-120

5'-adenosine monophosphate-activated protein kinase-Mammalian target of rapamycin axis as therapeutic target for age-related macular degeneration

Hyttinen JM, Petrovski G, Salminen A, Kaarniranta K. 2011. Rejuvenation research. 14: 651-660

AMP-activated protein kinase inhibits NF-kappaB signaling and inflammation: impact on healthspan and lifespan

Salminen A, Hyttinen JMT, Kaarniranta K. 2011. Journal of molecular medicine: jmm. 89: 667-676

Celastrol regulates innate immunity response via NF-kappaB and Hsp70 in human retinal pigment epithelial cells

Paimela T, Hyttinen JMT, Viiri J, Ryhänen T, Karjalainen RO, Salminen A, Kaarniranta K. 2011. Pharmacological research. 64: 501-508

Endoplasmic reticulum stress in age-related macular degeneration: Trigger for neovascularization

Salminen A, Kauppinen A, Hyttinen JMT, Toropainen E & Kaarniranta K. 2010. MOLECULAR MEDICINE TODAY. 16: 535-542

Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells

Ryhänen T, Viiri J, Hyttinen JTM, Uusitalo H, Salminen A & Kaarniranta K. 2010. Journal of biomedicine and biotechnology. 2011;2011;798052. Epub 2010 Oct 24: 1-8

Mechanisms of protein aggregation in the retinal pigment epithelial cells

Kai Kaarniranta, Juha Hyttinen, Tuomas Ryhanen, Johanna Viiri, Tuomas Paimela, Elisa Toropainen, Iiris Sorri & Antero Salminen. 2010. FRONTIERS IN BIOSCIENCE. E2: 1374-1384

p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells

Viiri J, Hyttinen JMT, Ryhänen T, Rilla K, Paimela T, Kuusisto E, Siitonen A, Urtti A, Salminen A & Kaarniranta K. 2010. Molecular vision. 16: 1399-1414

Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro

Viiri J, Jauhonen HM, Kauppinen A, Ryhänen T, Paimela T, Hyttinen J, Sorri I, Laihia JK, Leino L, Kaarniranta K. 2009. Molecular vision. 15: 1799-1805

Regulation of ERalfa signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90

Suuronen T, Ojala J, Hyttinen JMT, Kaarniranta K, Thornell A, Kyrylenko S, Salminen A. 2008. Neurochemical research. 33: 1768-1775

Hyaluronan degradation in epidermis

Tammi RH, Pasonen-Seppänen S, Kultti A, Hyttinen JMT, MacCallum DK, Hascall VC, Tammi MI. Teoksessa: Balazs EA, Hascall VC(toim.) , 2005. Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications. s. 241-245. Matrix Biology Institute

Plasma membrane residence of hyaluronan synthase is coupled to its entzymatic activity

Rilla K, Siiskonen H, Spicer AP, Hyttinen JMT, Tammi MI, Tammi RH. 2005. Journal of biological chemistry. 280: 31890-31897

Suppression of hyaluronan synthesis by 4-methylumbelliferone retards keratinocyte migration and proliferation

Rilla K, Hyttinen JMT, Törrönen K, Pasonen-Seppänen S, Heldin P, Spicer AP, Rieppo J, Mättö M, Tammi M, Tammi R. Teoksessa: Balazs EA, Hascall VC(toim.) , 2005. Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications. Hyaluronan 2003.. s. 637-640. Matrix Biology Institute

Wounding-induced upregulations of Has2/Has3 expression and hyaluronan synthesis in adult mouse epidermis correlates with keratinocyte migration and proliferation

Pasonen-Seppänen S, Hyttinen J, Kolehmainen E, Tammi M, Tammi R. Teoksessa: Balazs EA, Hascall VC(toim.) , 2005. Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications Hyaluronan 2003. s. 561-564. Matrix Biologu Institute

Heparin modulates the growth and adherence and augments the gowth-inhibitory action of TNF-alpha on cultured human keratinocytes

Harvima IT, Lappalainen K, Hirvonen MR, Matto M, Kivinen PK, Hyttinen M, Pelkonen J, Naukkarinen A. 2004. Journal of cellular biochemistry. 92: 372-386

EGF upregulates, whereas TGF-beta downregulates, the hyaluronan synthases Has2 and Has3 in organotypic keratinocyte cultures: correlations with epidermal proliferation and differentiation

Pasonen-Seppänen S, Karvinen S, Törrönen K, Hyttinen JMT, Jokela T, Lammi MJ, Tammi MI, Tammi R. 2003. Journal of investigative dermatology. 120: 1038-1044

Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3

Karvinen S, Pasonen-Seppänen S, Hyttinen JMT, Pienimäki J-P, Törrönen K, Jokela TA, Tammi MI, Tammi R. 2003. Journal of biological chemistry. 278: 49495-49504

Chlorinated Hydroxyfuranones. Studies on Their Mutagenicity and Molecular Mechanism of Action

Hyttinen JMT. 1996. Kuopion yliopiston julkaisuja C. Luonnontieteet ja ympäristötieteet

Kinds of mutations induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in the hprt gene of Chinese hamster ovary cells

Hyttinen JMT, Myöhänen S, Jansson K. 1996. Carcinogenesis. 17: 1179-1181

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Research groups

Non-Coding RNAs Regulating Mitochondrial Functions and the Oxidative Stress Response as Putative Targets against Age-Related Macular Degeneration (AMD)

Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice

MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy

Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3

Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice

Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration

Therapeutic potential of PGC-1α in age-related macular degeneration (AMD) - the involvement of mitochondrial quality control, autophagy, and antioxidant response

Autophagy Genes for Wet Age-Related Macular Degeneration in a Finnish Case-Control Study

Only IL-1ß release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted

UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells

Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Mitochondrial quality control in AMD: does mitophagy play a pivotal role?

Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells

DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells - Implications for age-related macular degeneration (AMD)

Hsp70 binds reversibly to proteasome inhibitor-induced protein aggregates and evades autophagic clearance in ARPE-19 cells

Oxidative stress plays an important role in zoledronic acid-induced autophagy

Pinosylvin-mediated protection against oxidative stress in human retinal pigment epithelial cells

Upregulation of inflammatory genes in the nasal mucosa of patients undergoing endonasal dacryocystorhinostomy

Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells

Hyaluronan synthase 1 (HAS1) produces a cytokine- and glucose-inducible, CD44-dependent cell surface coat

Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GIcNAc concentration than HAS2 and HAS3

Maturation of autophagosomes and endosomes: A key role for Rab7

Context-dependent regulation of autophagy by IKK-NF-kappaB signaling: Impact on the aging process

Role of CD44 in the organization of keratinocyte pericellular hyaluronan

5'-adenosine monophosphate-activated protein kinase-Mammalian target of rapamycin axis as therapeutic target for age-related macular degeneration

AMP-activated protein kinase inhibits NF-kappaB signaling and inflammation: impact on healthspan and lifespan

Celastrol regulates innate immunity response via NF-kappaB and Hsp70 in human retinal pigment epithelial cells

Endoplasmic reticulum stress in age-related macular degeneration: Trigger for neovascularization

Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells

Mechanisms of protein aggregation in the retinal pigment epithelial cells

p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells

Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro

Regulation of ERalfa signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90

Hyaluronan degradation in epidermis

Plasma membrane residence of hyaluronan synthase is coupled to its entzymatic activity

Suppression of hyaluronan synthesis by 4-methylumbelliferone retards keratinocyte migration and proliferation

Wounding-induced upregulations of Has2/Has3 expression and hyaluronan synthesis in adult mouse epidermis correlates with keratinocyte migration and proliferation

Heparin modulates the growth and adherence and augments the gowth-inhibitory action of TNF-alpha on cultured human keratinocytes

EGF upregulates, whereas TGF-beta downregulates, the hyaluronan synthases Has2 and Has3 in organotypic keratinocyte cultures: correlations with epidermal proliferation and differentiation

Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3

Chlorinated Hydroxyfuranones. Studies on Their Mutagenicity and Molecular Mechanism of Action

Kinds of mutations induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in the hprt gene of Chinese hamster ovary cells