Juha Töyräs

Arousal burden is highest in supine sleeping position and during light sleep

Pitkänen, Minna; Huovinen, Juho; Rissanen, Marika; Pitkänen, Henna; Kainulainen, Samu; Penzel, Thomas; Fanfulla, Francesco; Anttalainen, Ulla; Saaresranta, Tarja; Grote, Ludger; Hedner, Jan; Staats, Richard; Duce, Brett; Töyräs, Juha; Oksenberg, Arie; Leppänen, Timo. 2024. Journal of clinical sleep medicine. [Published Online October 4, 2024]: . A1 Journal article (refereed), original research

Beat-to-beat cardiac repolarization lability increases during hypoxemia and arousals in obstructive sleep apnea patients

Ebrahimian, Serajeddin; Sillanmäki, Saara; Hietakoste, Salla; Kulkas, Antti; Töyräs, Juha; Bailón, Raquel; Hernando, David; Lombardi, Carolina; Grote, Ludger; Bonsignore, Maria R; Saaresranta, Tarja; Pépin, Jean-Louis; Leppänen, Timo; Kainulainen, Samu. 2024. American journal of physiology : heart and circulatory physiology. 326: H1094-H1104 A1 Journal article (refereed), original research

Estimation of Photon Path Length and Penetration Depth in Articular Cartilage Zonal Architecture over the Therapeutic Window

Kafian-Attari, I; Nippolainen, E; Bergmann, F; George, A; Paakkari, P; Mirhashemi, A; Foschum, F; Kienle, A; Toyras, J; Afara, IO. 2024. IEEE transactions on biomedical engineering. 71: 2300-2311 A1 Journal article (refereed), original research

Increased Flow Limitation During Sleep Is Associated With Increased Psychomotor Vigilance Task Lapses in Individuals With Suspected OSA

Staykov, Eric; Mann, Dwayne L.; Duce, Brett; Kainulainen, Samu; Leppänen, Timo; Töyräs, Juha; Azarbarzin, Ali; Georgeson, Thomas; Sands, Scott A.; Terrill, Philip I.. 2024. Chest. 165: 990-1003 A1 Journal article (refereed), original research

Increased flow limitation during sleep is associated with decreased psychomotor vigilance task performance in individuals with suspected obstructive sleep apnea: a multi-cohort study

Staykov, Eric; Mann, Dwayne L; Leppänen, Timo; Töyräs, Juha; Kainulainen, Samu; Azarbarzin, Ali; Duce, Brett; Sands, Scott A; Terrill, Philip I; The STAGES Cohort Investigator Group. 2024. Sleep. 47: A1 Journal article (refereed), original research

Infrared Spectroscopy Can Differentiate Between Cartilage Injury Models: Implication for Assessment of Cartilage Integrity

Shahini, Fatemeh; Oskouei, Soroush; Nippolainen, Ervin; Mohammadi, Ali; Sarin, Jaakko K; Moller, Nikae CR te; Brommer, Harold; Shaikh, Rubina; Korhonen, Rami K; van Weeren, P. René; Töyräs, Juha; Afara, Isaac O. 2024. Annals of biomedical engineering. 52: 2521-2533 A1 Journal article (refereed), original research

Laser-irradiating infrared attenuated total reflection spectroscopy of articular cartilage: Potential and challenges for diagnosing osteoarthritis

Krebs, P; Nägele, M; Fomina, P; Virtanen, V; Nippolainen, E; Shaikh, R; Afara, I O; Töyräs, J; Usenov, I; Sakharova, T; Artyushenko, V; Tafintseva, V; Solheim, J H; Zimmermann, B; Kohler, A; König, O; Saarakkala, S; Mizaikoff, B. 2024. Osteoarthritis and cartilage open. 6: . 100466 A1 Journal article (refereed), original research

Prolonged lung-to-finger circulation time indicates an increased risk of intermittent hypoxaemia in sleep apnoea patients

Pahari, Purbanka; Korkalainen, Henri; Arnardóttir, Erna Sif; Islind, Anna Sigridur; August, Elias; Oksenberg, Arie; Töyräs, Juha; Leppänen, Timo; Nikkonen, Sami. 2024. ERJ open research. 10: . 01051-2023 A1 Journal article (refereed), original research

Relationship between depth-wise refractive index and biomechanical properties of human articular cartilage

Khan, Bilour; Nippolainen, Ervin; Shahini, Fatemeh; Nonappa; Popov, Alexey; Töyräs, Juha; Afara, Isaac O. 2024. Journal of biomedical optics. 29: 1-12 A1 Journal article (refereed), original research

Respiratory event index underestimates severity of sleep apnea compared to apnea-hypopnea index

Pitkänen, Minna; Nath, Rajdeep Kumar; Korkalainen, Henri; Nikkonen, Sami; Mahamid, Alaa; Oksenberg, Arie; Duce, Brett; Töyräs, Juha; Kainulainen, Samu; Leppänen, Timo. 2024. Sleep advances. 5: . zpad054 A1 Journal article (refereed), original research

Retrospective validation of automatic sleep analysis with grey areas model for human‐in‐the‐loop scoring approach

Rusanen, Matias; Jouan, Gabriel; Huttunen, Riku; Nikkonen, Sami; Sigurðardóttir, Sigríður; Töyräs, Juha; Duce, Brett; Myllymaa, Sami; Arnardottir, Erna Sif; Leppänen, Timo; Islind, Anna Sigridur; Kainulainen, Samu; Korkalainen, Henri. 2024. Journal of sleep research. [First published: 23 October 2024]: 1-13 A1 Journal article (refereed), original research

Site-specific elastic and viscoelastic biomechanical properties of healthy and osteoarthritic human knee joint articular cartilage

Linus, Awuniji; Tanska, Petri; Nippolainen, Ervin; Tiitu, Virpi; Töyras, Juha; Korhonen, Rami K; Afara, Isaac O; Mononen, Mika E. 2024. Journal of biomechanics. 169: . 112135 A1 Journal article (refereed), original research

Sleep stage continuity is associated with objective daytime sleepiness in patients with suspected obstructive sleep apnea

Chen, Xin; Leppänen, Timo; Kainulainen, Samu; Howarth, Timothy P; Oksenberg, Arie; Töyräs, Juha; Terrill, Philip I; Korkalainen, Henri. 2024. Journal of clinical sleep medicine. 20: 1595-1606 A1 Journal article (refereed), original research

Temporal and sleep stage‐dependent agreement in manual scoring of respiratory events

Pitkänen, Minna; Pitkänen, Henna; Nath, Rajdeep Kumar; Nikkonen, Sami; Kainulainen, Samu; Korkalainen, Henri; Ólafsdóttir, Kristín Anna; Arnardottir, Erna Sif; Sigurdardottir, Sigridur; Penzel, Thomas; Fanfulla, Francesco; Anttalainen, Ulla; Saaresranta, Tarja; Grote, Ludger; Hedner, Jan; Staats, Richard; Töyräs, Juha; Leppänen, Timo. 2024. Journal of sleep research. [First published: 04 November 2024]: 1-10 A1 Journal article (refereed), original research

Variation in the Photoplethysmogram Response to Arousal From Sleep Depending on the Cause of Arousal and the Presence of Desaturation

Luukinen, Mieli; Pitkänen, Henna; Leppänen, Timo; Töyräs, Juha; Islind, Anna Sigridur; Kainulainen, Samu; Korkalainen, Henri. 2024. IEEE journal of translational engineering in health and medicine. 12: 328-339 A1 Journal article (refereed), original research

“An excellent servant but a terrible master”: Understanding the value of wearables for self-management in people with cystic fibrosis and their healthcare providers – A qualitative study

Mattison, Graeme; Canfell, Oliver J; Smith, Daniel; Forrester, Doug; Reid, David; Töyräs, Juha; Dobbins, Chelsea. 2024. International journal of medical informatics. 189: A1 Journal article (refereed), original research

3-D T1 relaxation time measurements in an equine model of subtle post-traumatic osteoarthritis using MB-SWIFT

Pala, Swetha; Hänninen, Nina E; Mohammadi, Ali; Ebrahimi, Mohammadhossein; te Moller, Nikae CR; Brommer, Harold; René van Weeren, P; Mäkelä, Janne TA; Korhonen, Rami K; Afara, Isaac O; Töyräs, Juha; Mikkonen, Santtu; Nissi, Mikko J; Nykänen, Olli. 2023. Journal of orthopaedic research. 41: 2657-2666 A1 Journal article (refereed), original research

Acute cardiorespiratory coupling impairment in worsening sleep apnea-related intermittent hypoxemia

Hietakoste, Salla; Armanac-Julian, Pablo; Karhu, Tuomas; Bailon, Raquel; Sillanmäki, Saara; Töyräs, Juha; Leppänen, Timo; Myllymaa, Sami; Kainulainen, Samu. 2023. IEEE transactions on biomedical engineering. 2024; 71: 326-333 A1 Journal article (refereed), original research

Articular Cartilage Characterization Using Tantalum and Iodine-based Dual-Contrast Photon-Counting Computed Tomography

Paakkari, Petri; Inkinen, Satu; Jäntti, Jiri; Tuppurainen, Juuso; Fugazzola, Maria; Joenathan, Anisha; Ylisiurua, Sampo; Nieminen, Miika; Grinstaff, Mark; Kröger, Heikki; Töyräs, Juha; Honkanen, Juuso; Mäkelä, Janne. 2023. Transactions of the annual meeting of the Orthopaedic Research Society abstract

Automated Tool for Musculoskeletal Finite Element Modeling of Knee

Esrafilian, Amir; Chandra, Shakes; Gatti, Anthony A; Töyräs, Juha; Saxby, David J; Lloyd, David G; Korhonen, Rami K;. 2023. abstract

Broadband scattering properties of articular cartilage zones and their relationship with the heterogenous structure of articular cartilage extracellular matrix

Kafian-Attari, Iman; Nippolainen, Ervin; Bergmann, Florian; George, Akuroma; Paakkari, Petri; Mirhashemi, Arash; Foschum, Florian; Kienle, Alwin; Töyräs, Juha; Afara, Isaac O. 2023. Journal of biomedical optics. 28: A1 Journal article (refereed), original research

Cationic tantalum oxide nanoparticle contrast agent for micro computed tomography reveals articular cartilage proteoglycan distribution and collagen architecture alterations

Jäntti, Jiri; Joenathan, Anisha; Fugazzola, Maria; Tuppurainen, Juuso; Honkanen, Juuso TJ; Töyräs, Juha; van Weeren, René; Snyder, Brian D; Grinstaff, Mark W; Matikka, Hanna; Mäkelä, Janne TA. 2023. Osteoarthritis and cartilage. 2024; 32: 299-309 A1 Journal article (refereed), original research

Characterisation of Cartilage Damage via Fusing Mid-Infrared, Near-Infrared, and Raman Spectroscopic Data

Shaikh, Rubina; Tafintseva, Valeria; Nippolainen, Ervin; Virtanen, Vesa; Solheim, Johanne; Zimmermann, Boris; Saarakkala, Simo; Töyräs, Juha; Kohler, Achim; Afara, Isaac O. 2023. Journal of personalized medicine. 13: A1 Journal article (refereed), original research

Deep learning-based algorithm accurately classifies sleep stages in preadolescent children with sleep-disordered breathing symptoms and age-matched controls

Somaskandhan, Pranavan; Leppänen, Timo; Terrill, Philip I; Sigurdardottir, Sigridur; Arnardottir, Erna Sif; Ólafsdóttir, Kristín A; Serwatko, Marta; Sigurðardóttir, Sigurveig Þ; Clausen, Michael; Töyräs, Juha; Korkalainen, Henri. 2023. Frontiers in neurology. 14: . 1162998 A1 Journal article (refereed), original research

Effect Of Depth-dependent Variation In Articular Cartilage Composition On Nanoparticle Diffusion

Jäntti, Jiri; Joenathan, Anisha; Fugazzola, Maria C; van Weeren, René; Synder, Brian D; Grinstaff, Mark W; Töyräs, Juha; Matikka, Hanna; Mäkelä, Janne TA. 2023. Transactions of the annual meeting of the Orthopaedic Research Society abstract

Generalizable Deep Learning-based Sleep Staging Approach for Ambulatory Textile Electrode Headband Recordings

Rusanen, Matias; Huttunen, Riku; Korkalainen, Henri; Myllymaa, Sami; Toyras, Juha; Myllymaa, Katja; Sigurdardottir, Sigridur; Olafsdottir, Kristin Anna; Leppanen, Timo; Arnardottir, Erna Sif; Kainulainen, Samu. 2023. IEEE journal of biomedical and health informatics. 27: 1869-1880 A1 Journal article (refereed), original research

Impact of experimental setup parameters on the measurement of articular cartilage optical properties in the visible and short near-infrared spectral bands

Kafian-Attari, Iman; Nippolainen, Ervin; Bergmann, Florian; Mirhashemi, Arash; Paakkari, Petri; Foschum, Florian; Kienle, Alwin; Töyräs, Juha; Afara, Isaac O.. 2023. Biomedical optics express. 14: 3397-3412 A1 Journal article (refereed), original research

Nasal Pressure Derived Airflow Limitation and Ventilation Measurements are Resilient to Reduced Signal Quality

Staykov, Eric; Mann, Dwayne L; Kainulainen, Samu; Duce, Brett; Leppänen, Timo; Töyräs, Juha; Sands, Scott A; Terrill, Philip I. Teoksessa: (toim.) , 2023. 2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Conference (EMBC): Proceedings. s. 4 pp.. IEEE A4 Conference proceedings

Near-infrared spectroscopic assessment of patellar tendon mechanics

Kositsky, Adam; Torniainen, Jari; Stenroth, Lauri; Nippolainen, Ervin; Mäkelä, Janne TA; Paakkari, Petri; Kröger, Heikki; Töyräs, Juha; Korhonen, Rami K; Afara, Isaac O. 2023. abstract

Obstructive Sleep Apnea Patients With Atrial Arrhythmias Suffer From Prolonged Recovery From Desaturations

Rissanen, Marika; Korkalainen, Henri; Duce, Brett; Sillanmaki, Saara; Pitkanen, Henna; Suni, Aaron; Nikkonen, Sami; Kulkas, Antti; Toyras, Juha; Leppanen, Timo; Kainulainen, Samu. 2023. IEEE transactions on biomedical engineering. 70: 2122-2130 A1 Journal article (refereed), original research

Oxygen resaturation rate is significantly associated with objectively assessed excessive daytime sleepiness in suspected obstructive sleep apnoea patients

Howarth, Timothy P.; Karhu, Tuomas; Kainulainen, Samu; Chen, Xin; Mahamid, Alaa; Töyräs, Juha; Leppänen, Timo. 2023. Sleep medicine. 107: 171-178 A1 Journal article (refereed), original research

Patellar tendon and tibial cartilage viscoelastic properties are inversely related in osteoarthritic knees

Kositsky, Adam; Linus, Awuniji; Stenroth, Lauri; Mononen, Mika E; Nippolainen, Ervin; Kröger, Heikki; Töyräs, Juha; Mäkelä, Janne TA; Tanska, Petri; Afara, Isaac O; Korhonen, Rami K. 2023. Transactions of the annual meeting of the Orthopaedic Research Society abstract

Power spectral analysis of the sleep electroencephalogram in positional obstructive sleep apnea

Duce, Brett; Kulkas, Antti; Oksenberg, Arie; Töyräs, Juha; Hukins, Craig. 2023. Sleep medicine. 104: 83-89 A1 Journal article (refereed), original research

Raman Spectroscopy and Machine Learning Enables Estimation of Articular Cartilage Structural, Compositional, and Functional Properties

Shehata, Eslam; Nippolainen, Ervin; Shaikh, Rubina; Ronkainen, Ari Petteri; Töyräs, Juha; Sarin, Jaakko K; Afara, Isaac O. 2023. Annals of biomedical engineering. 51: 2301-2312 A1 Journal article (refereed), original research

Reaction time in psychomotor vigilance task is related to hypoxic load in males with sleep apnea

Pahari, Purbanka; Korkalainen, Henri; Karhu, Tuomas; Arnardottir, Erna Sif; Töyräs, Juha; Leppänen, Timo; Nikkonen, Sami. 2023. Journal of sleep research. 2024; 33: A1 Journal article (refereed), original research

Refractive index of human articular cartilage varies with tissue structure and composition

Khan, Bilour; Nippolainen, Ervin; Shahini, Fatemeh; Torniainen, Jari; Mikkonen, Santtu; Nonappa, null; Popov, Alexey; Toyras, Juha; Afara, Isaac O.. 2023. Journal of the optical society of america a: optics image science and vision. 40: 2205-2214 A1 Journal article (refereed), original research

Review and perspective on sleep-disordered breathing research and translation to clinics

Korkalainen, Henri; Kainulainen, Samu; Islind, Anna Sigridur; Óskarsdóttir, María; Strassberger, Christian; Nikkonen, Sami; Töyräs, Juha; Kulkas, Antti; Grote, Ludger; Hedner, Jan; Sund, Reijo; Hrubos-Strom, Harald; Saavedra, Jose M.; Ólafsdóttir, Kristín Anna; Ágústsson, Jón S.; Terrill, Philip I.; McNicholas, Walter T.; Arnardóttir, Erna Sif; Leppänen, Timo. 2023. Sleep medicine reviews. 2024; 73: A2 Review article, Literature review, Systematic review

Self‐applied somnography: technical feasibility of electroencephalography and electro‐oculography signal characteristics in sleep staging of suspected sleep‐disordered adults

Rusanen, Matias; Korkalainen, Henri; Gretarsdottir, Heidur; Siilak, Tiina; Olafsdottir, Kristin Anna; Töyräs, Juha; Myllymaa, Sami; Arnardottir, Erna Sif; Leppänen, Timo; Kainulainen, Samu. 2023. Journal of sleep research. 2024; 33: . e13977 A1 Journal article (refereed), original research

Tantalum And Iodine Based Dual-Contrast Photon-Counting Computed Tomography Method For Assessment Of Articular Cartilage Composition

Paakkari, P; Inkinen, SI; Jäntti, J; Tuppurainen, J; Fugazzola, MC; Joenathan, A; Ylisiurua, S; Nieminen, MT; Grinstaff, MW; Kröger, H; Töyräs, J; Honkanen, JT; Mäkelä, JT. 2023. Osteoarthritis and cartilage abstract

Tantalum Oxide Nanoparticles For Contrast-Enhanced Computed Tomography Diagnosis Of Osteoarthritis

Jäntti, J; Joenathan, A; Honkanen, JT; Snyder, BD; Töyräs, J; Grinstaff, MW; Matikka, H; Mäkelä, JT. 2023. Osteoarthritis and cartilage abstract

Towards a Deeper Understanding of Sleep Stages through their Representation in the Latent Space of Variational Autoencoders

Biedebach, Luka; Rusanen, Matias; Pórðarson, Benedikt Hólm; Arnardóttir, Erna Sif; Óskarsdóttir, María; Nikkonen, Sami; Korkalainen, Henri; Myllymaa, Sami; Töyräs, Juha; Kainulainen, Samu; Leppänen, Timo; Islind, Anna Sigridur. Teoksessa: Bui, Tung(toim.) , 2023. Proceedings of the 56th Annual Hawaii International Conference on System Sciences. s. 3111-3120. Hawaii International Conference on System Sciences A4 Conference proceedings

Triple contrast computed tomography reveals site‐specific biomechanical differences in human knee joint – a proof of concept study

Orava, Heta; Paakkari, Petri; Jäntti, Jiri; Honkanen, Miitu KM; Honkanen, Juuso TJ; Virén, Tuomas; Joenathan, Anisha; Tanska, Petri; Korhonen, Rami K; Grinstaff, Mark W; Töyräs, Juha; Mäkelä, Janne TA. 2023. Journal of orthopaedic research. 2024; 42: 415-424 A1 Journal article (refereed), original research

Visible and Near-Infrared Spectroscopy Enables Differentiation of Normal and Early Osteoarthritic Human Knee Joint Articular Cartilage

Linus, Awuniji; Tanska, Petri; Sarin, Jaakko K.; Nippolainen, Ervin; Tiitu, Virpi; Mäkelä, Janne T.A.; Töyräs, Juha; Korhonen, Rami K.; Mononen, Mika E.; Afara, Isaac O.. 2023. Annals of biomedical engineering. 51: 2245-2257 A1 Journal article (refereed), original research

A Comparison of Signal Combinations for Deep Learning-Based Simultaneous Sleep Staging and Respiratory Event Detection

Huttunen, Riku; Leppanen, Timo; Duce, Brett; Arnardottir, Erna S.; Nikkonen, Sami; Myllymaa, Sami; Toyras, Juha; Korkalainen, Henri. 2022. IEEE transactions on biomedical engineering. [Date of Publication: 28 November 2022]: 1-12 A1 Journal article (refereed), original research

ABOSA – Freely available automatic blood oxygen saturation signal analysis software: Structure and validation

Karhu, Tuomas; Leppänen, Timo; Töyräs, Juha; Oksenberg, Arie; Myllymaa, Sami; Nikkonen, Sami. 2022. Computer methods and programs in biomedicine. 226: A1 Journal article (refereed), original research

Assessment of Ligament Viscoelastic Properties Using Raman Spectroscopy

Cui, Andy; Nippolainen, Ervin; Shaikh, Rubina; Torniainen, Jari; Ristaniemi, Aapo; Finnilä, Mikko; Korhonen, Rami K.; Saarakkala, Simo; Herzog, Walter; Töyräs, Juha; Afara, Isaac O.. 2022. Annals of biomedical engineering. 50: 1134-1142 A1 Journal article (refereed), original research

Deep Learning Enables Accurate Automatic Sleep Staging Based on Ambulatory Forehead EEG

Leino, Akseli; Korkalainen, Henri; Kalevo, Laura; Nikkonen, Sami; Kainulainen, Samu; Ryan, Alexander; Duce, Brett; Sipila, Kirsi; Ahlberg, Jari; Sahlman, Johanna; Miettinen, Tomi; Westeren-Punnonen, Susanna; Mervaala, Esa; Toyras, Juha; Myllymaa, Sami; Leppanen, Timo; Myllymaa, Katja. 2022. IEEE access. 10: 26554-26566 A1 Journal article (refereed), original research

Desaturation event scoring criteria affect the perceived severity of nocturnal hypoxic load

Karhu, Tuomas; Leppänen, Timo; Korkalainen, Henri; Myllymaa, Sami; Duce, Brett; Töyräs, Juha; Nikkonen, Sami. 2022. Sleep medicine. 100: 479-486 A1 Journal article (refereed), original research

Dual‐contrast micro‐CT enables cartilage lesion detection and tissue condition evaluation ex vivo

Honkanen, Miitu KM; Mohammadi, Ali; te Moller, Nikae CR; Ebrahimi, Mohammadhossein; Xu, Wujun; Plomp, Saskia; Pouran, Behdad; Lehto, Vesa‐Pekka; Brommer, Harold; van Weeren, P René; Korhonen, Rami K; Töyräs, Juha; Mäkelä, Janne TA. 2022. Equine veterinary journal. 2023; 55: 315-324 A1 Journal article (refereed), original research

Gamma Power of Electroencephalogram Arousal is Modulated by Respiratory Event Type and Severity in Obstructive Sleep Apnea

Pitkanen, Henna; Duce, Brett; Leppänen, Timo; Kainulainen, Samu; Kulkas, Antti; Myllymaa, Sami; Töyräs, Juha; Korkalainen, Henri. 2022. IEEE transactions on biomedical engineering. 69: 1417-1423 A1 Journal article (refereed), original research

Infrared spectroscopy is suitable for objective assessment of articular cartilage health

Virtanen, V; Tafintseva, V; Shaikh, R; Nippolainen, E; Haas, J; Afara, IO; Töyräs, J; Kröger, H; Solheim, J; Zimmermann, B; Kohler, A; Mizaikoff, B; Finnilä, M; Rieppo, L; Saarakkala, S. 2022. Osteoarthritis and cartilage open. 4: A1 Journal article (refereed), original research

Inter-sleep stage variations in corrected QT interval differ between obstructive sleep apnea patients with and without stroke history

Ebrahimian, Serajeddin; Sillanmäki, Saara; Hietakoste, Salla; Duce, Brett; Kulkas, Antti; Töyräs, Juha; Leppänen, Timo; Lipponen, Jukka A.; Kainulainen, Samu. 2022. PLoS ONE. 17: A1 Journal article (refereed), original research

Near infrared spectroscopic evaluation of biochemical and crimp properties of knee joint ligaments and patellar tendon

Torniainen, Jari; Ristaniemi, Aapo; Sarin, Jaakko K; Prakash, Mithilesh; Afara, Isaac O; Finnilä, Mikko AJ; Stenroth, Lauri; Korhonen, Rami K; Töyräs, Juha. 2022. PLoS ONE. 17: A1 Journal article (refereed), original research

Near-Infrared Spectroscopy Enables Arthroscopic Histologic Grading of Human Knee Articular Cartilage

Sarin, Jaakko K.; Prakash, Mithilesh; Shaikh, Rubina; Torniainen, Jari; Joukainen, Antti; Kröger, Heikki; Afara, Isaac O.; Töyräs, Juha. 2022. Arthroscopy, sports medicine, and rehabilitation. 4: e1767-e1775 A1 Journal article (refereed), original research

Novel oxygen desaturation parameters are associated with cardiac troponin I: Data from the Akershus Sleep Apnea Project

Sigurdardottir, Fjola D.; Øverby, Caroline Tonje; Nikkonen, Sami; Karhu, Tuomas; Dammen, Toril; Nordhus, Inger Hilde; Thorshov, Thea; Einvik, Gunnar; Kainulainen, Samu; Leppänen, Timo; Arnardottir, Erna Sif; Töyräs, Juha; Omland, Torbjørn; Hrubos‐Strøm, Harald. 2022. Journal of sleep research. 31: . e13581 A1 Journal article (refereed), original research

OSA-related respiratory events and desaturation severity are associated with the cardiac response

Hietakoste, Salla; Karhu, Tuomas; Sillanmäki, Saara; Bailón, Raquel; Penzel, Thomas; Töyräs, Juha; Leppänen, Timo; Myllymaa, Sami; Kainulainen, Samu. 2022. ERJ open research. 8: A1 Journal article (refereed), original research

Obstructive sleep apnea‐related intermittent hypoxaemia is associated with impaired vigilance

Pahari, Purbanka; Korkalainen, Henri; Karhu, Tuomas; Rissanen, Marika; Arnardottir, Erna Sif; Hrubos‐Strøm, Harald; Duce, Brett; Töyräs, Juha; Leppänen, Timo; Nikkonen, Sami. 2022. Journal of sleep research. [First published: 08 December 2022]: A1 Journal article (refereed), original research

Pulse Oximetry: The Working Principle, Signal Formation, and Applications

Leppänen, Timo; Kainulainen, Samu; Korkalainen, Henri; Sillanmäki, Saara; Kulkas, Antti; Töyräs, Juha; Nikkonen, Sami. Teoksessa: Penzel, T; Hornero, R(toim.) , 2022. Advances in the Diagnosis and Treatment of Sleep Apnea. s. 205-218. Springer A3 Book section, Chapters in research books

QTc prolongation is associated with severe desaturations in stroke patients with sleep apnea

Sillanmäki, Saara; Lipponen, Jukka A; Korkalainen, Henri; Kulkas, Antti; Leppänen, Timo; Nikkonen, Sami; Töyräs, Juha; Duce, Brett; Suni, Aaron; Kainulainen, Samu. 2022. Bmc pulmonary medicine. 22: . 204 A1 Journal article (refereed), original research

STAR sleep recording export software for automatic export and anonymization of sleep studies

Nikkonen, Sami; Korkalainen, Henri; Töyräs, Juha; Leppänen, Timo. 2022. Scientific reports. 12: . 15859 A1 Journal article (refereed), original research

Self-Applied Electrode Set Provides a Clinically Feasible Solution Enabling EEG Recording in Home Sleep Apnea Testing

Kalevo, Laura; Miettinen, Tomi; Leino, Akseli; Westeren-Punnonen, Susanna; Sahlman, Johanna; Mervaala, Esa; Toyras, Juha; Leppanen, Timo; Myllymaa, Sami; Myllymaa, Katja. 2022. IEEE access. 10: 60633-60642 A1 Journal article (refereed), original research

Site- and Zone-Dependent Changes in Proteoglycan Content and Biomechanical Properties of Bluntly and Sharply Grooved Equine Articular Cartilage

Mohammadi, Ali; te Moller, Nikae C. R.; Ebrahimi, Mohammadhossein; Plomp, Saskia; Brommer, Harold; van Weeren, P. René; Mäkelä, Janne T. A.; Töyräs, Juha; Korhonen, Rami K.. 2022. Annals of biomedical engineering. 50: 1787–1797 A1 Journal article (refereed), original research

Tantalum Oxide Nanoparticles for Contrast Enhanced Computed Tomography Imaging of Cartilage

Jäntti, J; Joenathan, A; Fugazzola, M; van Weeren, R; Synder, BD; Grinstaff, MW; Töyräs, J; Matikka, H; Mäkelä, JT. 2022. Osteoarthritis and cartilage abstract

The Influence of Wearables on Health Care Outcomes in Chronic Disease: Systematic Review

Mattison, Graeme; Canfell, Oliver; Forrester, Doug; Dobbins, Chelsea; Smith, Daniel; Töyräs, Juha; Sullivan, Clair. 2022. Journal of medical internet research. 24: A2 Review article, Literature review, Systematic review

The Sleep Revolution project: the concept and objectives

Arnardottir, Erna S; Islind, Anna Sigridur; Óskarsdóttir, María; Ólafsdóttir, Kristín A; August, Elias; Jónasdóttir, Lára; Hrubos‐Strøm, Harald; Saavedra, Jose M; Grote, Ludger; Hedner, Jan; Höskuldsson, Sveinbjörn; Ágústsson, Jón Skírnir; Jóhannsdóttir, Kamilla Rún; McNicholas, Walter T; Pevernagie, Dirk; Sund, Reijo; Töyräs, Juha; Leppänen, Timo. 2022. Journal of sleep research. 31: . e13630 A2 Review article, Literature review, Systematic review

The severity and morphology of intermittent hypoxemias are related to impaired daytime alertness

Pahari, P; Korkalainen, H; Karhu, T; Rissanen, M; Arnardottir, ES; Strøm, HH; Duce, B; Töyräs, J; Leppänen, T; Nikkonen, S. 2022. Sleep medicine abstract

An In-Laboratory Comparison of FocusBand EEG Device and Textile Electrodes Against a Medical-Grade System and Wet Gel Electrodes

Rusanen, Matias; Myllymaa, Sami; Kalevo, Laura; Myllymaa, Katja; Töyräs, Juha; Leppanen, Timo; Kainulainen, Samu. 2021. IEEE access. 9: 132580-132591 A1 Journal article (refereed), original research

Articular cartilage optical properties in the near-infrared (NIR) spectral range vary with depth and tissue integrity

Khan, Bilour; Kafian-Attari, Iman; Nippolainen, Ervin; Shaikh, Rubina; Semenov, Dmitry; Hauta-Kasari, Markku; Töyräs, Juha; Afara, Isaac O.. 2021. Biomedical optics express. 12: 6066-6080 A1 Journal article (refereed), original research

Assessment of Obstructive Sleep Apnea-Related Sleep Fragmentation Utilizing Deep Learning-Based Sleep Staging from Photoplethysmography

Huttunen, R; Leppänen, T; Duce, B; Oksenberg, A; Myllymaa, S; Töyräs, J; Korkalainen, H. 2021. Sleep. 44: zsab142 A1 Journal article (refereed), original research

Automatic Respiratory Event Scoring in Obstructive Sleep Apnea Using a Long Short-Term Memory Neural Network

Nikkonen, Sami; Korkalainen, Henri; Leino, Akseli; Myllymaa, Sami; Duce, Brett; Leppänen, Timo; Töyräs, Juha. 2021. IEEE journal of biomedical and health informatics. 25: 2917-2927 A1 Journal article (refereed), original research

Auttaako teknologia uniongelmiin?

Kainulainen, S; Töyräs, J; Leppänen, T. 2021. Tekniikan maailma. : 68-72 E1 Popularised article, newspaper article

Beyond the apnea-hypopnea index: alternative diagnostic parameters and machine learning solutions for estimation of sleep apnea severity

Leppänen, Timo; Myllymaa, Sami; Kulkas, Antti; Töyräs, Juha. 2021. Sleep. 44: 1 - 3 B1 Non-refereed journal articles

Biomechanical, biochemical, and near infrared spectral data of bovine knee ligaments and patellar tendon

Ristaniemi, Aapo; Torniainen, Jari; Paakkonen, Tommi; Stenroth, Lauri; Finnilä, Mikko A.J.; Tanska, Petri; Töyräs, Juha; Korhonen, Rami K.. 2021. Data in brief. 36: 106976 A1 Journal article (refereed), original research

Characterization of connective tissues using near-infrared spectroscopy and imaging

Afara, Isaac O; Shaikh, Rubina; Nippolainen, Ervin; Querido, William; Torniainen, Jari; Sarin, Jaakko K; Kandel, Shital; Pleshko, Nancy; Töyräs, Juha. 2021. Nature protocols. 16: 1297-1329 A1 Journal article (refereed), original research

Detailed assessment of sleep architecture with deep learning and shorter epoch-to-epoch duration reveals sleep fragmentation of patients with obstructive sleep apnea

Korkalainen, Henri; Leppänen, Timo; Duce, Brett; Kainulainen, Samu; Aakko, Juhani; Leino, Akseli; Kalevo, Laura; Afara, Isaac O; Myllymaa, Sami; Töyräs, Juha. 2021. IEEE journal of biomedical and health informatics. 25: 2567-2574 A1 Journal article (refereed), original research

Diabetes and cardiovascular diseases are associated with the worsening of intermittent hypoxaemia

Karhu, T; Myllymaa, S; Nikkonen, S; Mazzotti, DR; Kulkas, A; Töyräs, J; Leppänen, T. 2021. Journal of sleep research. 2022; 31: e13441 A1 Journal article (refereed), original research

Dual-contrast computed tomography enables detection of equine posttraumatic osteoarthritis in vitro

Saukko, AEA; Sarin, JK; Nykänen, O; Nissi, MJ; Te Moller, NCR; Weinans, H; Mancini, IAD; Visser, J; Brommer, H; van Weeren, PR; Malda, J; Grinstaff, MW; Töyräs, J. 2021. Journal of orthopaedic research. 2022; 40: 703-711 A1 Journal article (refereed), original research

Functional and Structural Properties of Human Patellar Articular Cartilage in Osteoarthritis

Nissinen, Mikko T; Hänninen, Nina; Prakash, Mithilesh; Mäkelä, Janne TA; Nissi, Mikko J; Töyräs, Juha; Nieminen, Miika T. Korhonen, Rami K; Tanska, Petri. 2021. Journal of biomechanics. 126: 110634 A1 Journal article (refereed), original research

Infrared Fiber-Optic Spectroscopy Detects Bovine Articular Cartilage Degeneration

Virtanen, Vesa; Nippolainen, Ervin; Shaikh, Rubina; Afara, Isaac O; Töyräs, Juha; Solheim, Johanne; Tafintseva, Valeria; Zimmermann, Boris; Kohler, Achim; Saarakkala, Simo; Rieppo, Lassi. 2021. Cartilage. 13: 285S-294S A1 Journal article (refereed), original research

Longer and Deeper Desaturations Are Associated With the Worsening of Mild Sleep Apnea: The Sleep Heart Health Study

Karhu, Tuomas; Myllymaa, Sami; Nikkonen, Sami; Mazzotti, Diego R; Töyräs, Juha; Leppänen, Timo. 2021. Frontiers in neuroscience. 15: 657126 A1 Journal article (refereed), original research

Machine learning augmented near-infrared spectroscopy: In vivo follow-up of cartilage defects

Sarin, Jaakko K; Te Moller, Nikae Cr; Mohammadi, Ali; Prakash, Mithilesh; Torniainen, Jari; Brommer, Harold; Nippolainen, Ervin; Shaikh, Rubina; Mäkelä, Janne Ta; Korhonen, Rami K; René van Weeren, P; Afara, Isaac O; Töyräs, Juha. 2021. Osteoarthritis and cartilage. 29: 423-432 A1 Journal article (refereed), original research

Neural network analysis of nocturnal SpO2 signal enables easy screening of sleep apnea in patients with acute cerebrovascular disease

Leino, Akseli; Nikkonen, Sami; Kainulainen, Samu; Korkalainen, Henri; Töyräs, Juha; Myllymaa, Sami; Leppänen, Timo; Ylä-Herttuala, Salla; Westeren-Punnonen, Susanna; Muraja-Murro, Anu; Jäkälä, Pekka; Mervaala, Esa; Myllymaa, Katja. 2021. Sleep medicine. 79: 71-78 A1 Journal article (refereed), original research

Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health

Paakkari, Petri; Inkinen, Satu I; Honkanen, Miitu KM; Prakash, Mithilesh; Shaikh, Rubina; Nieminen, Miika T; Grinstaff, Mark W; Mäkelä, Janne TA; Töyräs, Juha; Honkanen, Juuso TJ. 2021. Scientific reports. 11: 5556 A1 Journal article (refereed), original research

Raman spectroscopy is sensitive to biochemical changes related to various cartilage injuries

Shaikh, Rubina; Nippolainen, Ervin; Virtanen, Vesa; Torniainen, Jari; Rieppo, Lassi; Saarakkala, Simo; Afara, Isaac O; Töyräs, Juha. 2021. Journal of raman spectroscopy. 52: 796-804 A1 Journal article (refereed), original research

Self-Applied Home Sleep Recordings: The Future of Sleep Medicine

Korkalainen, Henri; Nikkonen, Sami; Kainulainen, Samu; Dwivedi, Amit Krishna; Myllymaa, Sami; Leppänen, Timo; Töyräs, Juha. 2021. Sleep medicine clinics. 16: 545-556 A2 Review article, Literature review, Systematic review

Structure, composition and fibril-reinforced poroviscoelastic properties of bovine knee ligaments and patellar tendon

Ristaniemi, Aapo; Regmi, Dristi; Mondal, Diponkor; Torniainen, Jari; Tanska, Petri; Stenroth, Lauri; Finnilä, Mikko AJ; Töyräs, Juha; Korhonen, Rami K. 2021. Journal of the royal society interface. 18: 20200737 A1 Journal article (refereed), original research

Subject-specific biomechanical analysis to estimate locations susceptible to osteoarthritis - Finite element modeling and MRI follow-up of ACL reconstructed patients

Bolcos, Paul O; Mononen, Mika E; Roach, Koren E; Tanaka, Matthew S; Suomalainen, Juha-Sampo; Mikkonen, Santtu; Nissi, Mikko J; Töyräs, Juha; Link, Thomas M; Souza, Richard B; Majumdar, Sharmila; Ma, C Benjamin; Li, Xiaojuan; Korhonen, Rami K. 2021. Journal of orthopaedic research. [ePub ahead of print 24 Nov 2021]: 1-12 A1 Journal article (refereed), original research

Technical Performance of Textile-Based Dry Forehead Electrodes Compared With Medical-Grade Overnight Home Sleep Recordings

Rusanen, Matias; Kainulainen, Samu; Korkalainen, Henri; Kalevo, Laura; Myllymaa, Katja; Leppanen, Timo; Toyras, Juha; Arnardottir, Erna Sif; Myllymaa, Sami. 2021. IEEE access. 9: 157902 - 157915 A1 Journal article (refereed), original research

The effect of subchondral bone plate thickness and trabecular bone volume fraction on the mechanical behavior of cartilage in post-traumatic osteoarthritis

Orava, H; Tanska, P; Huang, L; Ojanen, SP; Mäkelä, JTA; Finnilä, MAJ; Saarakkala, S; Herzog, W; Korhonen, RK; Töyräs, J. 2021. Transactions of the annual meeting of the Orthopaedic Research Society poster

Total durations of respiratory events are modulated within REM and NREM sleep by sleeping position and obesity in OSA patients

Rissanen, M; Oksenberg, A; Töyräs, J; Myllymaa, S; Leppänen, T. 2021. Sleep medicine. 81: 394-400 A1 Journal article (refereed), original research

Acute stroke and TIA patients have specific polygraphic features of obstructive sleep apnea

Leino, A; Westeren-Punnonen, S; Töyräs, J; Myllymaa, S; Leppänen, T; Ylä-Herttuala, S; Muraja-Murro, A; Kantanen, AM; Autere, J; Jäkälä, P; Mervaala, E; Myllymaa, K. 2020. Sleep and breathing. 24: 1495-1505 A1 Journal article (refereed), original research

Automated Preprocessing of Near Infrared Spectroscopic Data

Torniainen, J; Afara, IO; Prakash, M; Sarin, JK; Stenroth, L; Töyräs, J. Teoksessa: -(toim.) , 2020. Bio-Optics: Design and Application 2019. s. DS2A.6. Optical Society of America A4 Conference proceedings

Bright ultra-short echo time SWIFT MRI signal at the osteochondral junction is not located in the calcified cartilage

Nykänen, Olli; Leskinen, Henri P P; Finnilä, Mikko; Karhula, Sakari S; Turunen, Mikael J; Töyräs, Juha; Saarakkala, Simo; Nissi, Mikko J. 2020. Journal of orthopaedic research. 38: 2649-2656 A1 Journal article (refereed), original research

Clinical Contrast-enhanced Computed Tomography with Semiautomatic Segmentation Provides Feasible Input for Computational Models of the Knee Joint

Myller, KAH; Korhonen, R; Töyräs, J; Tanska, P; Väänänen, S; Jurvelin, JS; Saarakkala, S; Mononen, ME. 2020. Journal of biomechanical engineering: transactions of the ASME. 142: 51001 A1 Journal article (refereed), original research

Comparison of the effect of weight change, simulated computational continuous positive airway pressure treatment and positional therapy on severity of sleep apnea

Kulkas, Antti; Duce, Brett; Töyräs, Juha; Seppä, Juha; Leppänen, Timo. 2020. Journal of sleep research. 2021; 30: e13070 A1 Journal article (refereed), original research

Comparison of water, hydroxyproline, uronic acid and elastin contents of bovine knee ligaments and patellar tendon and their relationships with biomechanical properties

Ristaniemi, A; Torniainen, J; Stenroth, L; Finnilä, MAJ; Paakkonen, T; Töyräs, J; Korhonen, RK. 2020. Journal of the mechanical behavior of biomedical materials. 104: 103639 A1 Journal article (refereed), original research

Deep learning enables sleep staging from photoplethysmogram for patients with suspected sleep apnea

Korkalainen, H; Aakko, J; Duce, B; Kainulainen, S; Leino, A; Nikkonen, S; Afara, I O; Myllymaa, S; Töyräs, J; Leppänen, T. 2020. Sleep. 43: zsaa098 A1 Journal article (refereed), original research

Discrete element and finite element methods provide similar estimations for hip joint contact mechanics during walking gait

Li, Mao; Venäläinen, Mikko S; Chandra, Shekhar S; Patel, Rushabh; Fripp, Jurgen; Engstrom, Craig; Korhonen, Rami K; Töyräs, Juha; Crozier, Stuart. 2020. Journal of biomechanics. 115: 110163 A1 Journal article (refereed), original research

Dual Contrast in Computed Tomography Allows Earlier Characterization of Articular Cartilage over Single Contrast

Bhattarai, Abhisek; Pouran, Behdad; Mäkelä, Janne T A; Shaikh, Rubina; Honkanen, Miitu K M; Prakash, Mithilesh; Kröger, Heikki; Grinstaff, Mark W; Weinans, Harrie; Jurvelin, Jukka S; Töyräs, Juha. 2020. Journal of orthopaedic research. 38: 2230-2238 A1 Journal article (refereed), original research

Effect of sweating on electrode-skin contact impedances and artifacts in EEG recordings with various screen-printed Ag/Agcl electrodes

Kalevo, Laura; Miettinen, Tomi; Leino, Akseli; Kainulainen, Samu; Korkalainen, Henri; Myllymaa, Katja; Töyräs, Juha; Leppänen, Timo; Laitinen, Tiina; Myllymaa, Sami. 2020. IEEE access. 8: 50934-50943 A1 Journal article (refereed), original research

Effects of Human Articular Cartilage Constituents on Simultaneous Diffusion of Cationic and Non-ionic Contrast Agents

Bhattarai, Abhisek; Mäkelä, Janne T A; Pouran, Behdad; Kröger, Heikki; Weinans, Harrie; Grinstaff, Mark W; Töyräs, Juha; Turunen, Mikael J. 2020. Journal of orthopaedic research. 2021; 39: 771-779 A1 Journal article (refereed), original research

Estimating daytime sleepiness with previous night EEG, EOG and EMG spectrograms in patients with suspected sleep apnea using a convolutional neural network

Nikkonen, Sami; Korkalainen, Henri; Kainulainen, Samu; Myllymaa, Sami; Leino, Akseli; Kalevo, Laura; Oksenberg, Arie; Leppänen, Timo; Töyräs, Juha. 2020. Sleep. 43: zsaa106 A1 Journal article (refereed), original research

Evaluation of articular cartilage with quantitative MRI in an equine model of post-traumatic osteoarthritis

Kajabi, Abdul Wahed; Casula, Victor; Sarin, Jaakko K; Ketola, Juuso H; Nykänen, Olli; Te Moller, Nikae C R; Mancini, Irina A D; Visser, Jetze; Brommer, Harold; René van Weeren, P; Malda, Jos; Töyräs, Juha; Nieminen, Miika T; Nissi, Mikko J. 2020. Journal of orthopaedic research. 2021; 39: 63-73 A1 Journal article (refereed), original research

Identification of locations susceptible to osteoarthritis in patients with anterior cruciate ligament reconstruction: Combining knee joint computational modelling with follow-up T1p and T2 imaging

Bolcos, PO; Mononen, ME; Tanaka, MS; Yang, M; Suomalainen, JS; Nissi, MJ; Töyräs, J; Ma, B; Li, X; Korhonen, RK. 2020. Clinical biomechanics. 79: 104844 A1 Journal article (refereed), original research

Increased nocturnal arterial pulsation frequencies of obstructive sleep apnoea patients is associated with an increased number of lapses in a psychomotor vigilance task

Kainulainen, Samu; Duce, Brett; Korkalainen, Henri; Leino, Akseli; Huttunen, Riku; Kalevo, Laura; Arnardottir, Erna S; Kulkas, Antti; Myllymaa, Sami; Töyräs, Juha; Leppänen, Timo. 2020. ERJ open research. 6: 00277-202 A1 Journal article (refereed), original research

Longer apneas and hypopneas are associated with greater ultra-short-term HRV in obstructive sleep apnea

Hietakoste, Salla; Korkalainen, Henri; Kainulainen, Samu; Sillanmäki, Saara; Nikkonen, Sami; Myllymaa, Sami; Duce, Brett; Töyräs, Juha; Leppänen, Timo. 2020. Scientific reports. 10: 21556 A1 Journal article (refereed), original research

Longer duration electroencephalogram arousals have a better relationship with impaired vigilance and health status in obstructive sleep apnoea

Duce, Brett; Kulkas, Antti; Töyräs, Juha; Terrill, Philip; Hukins, Craig. 2020. Sleep and breathing. 2021; 25: 263-270 A1 Journal article (refereed), original research

Machine Learning Classification of Articular Cartilage Integrity Using Near Infrared Spectroscopy

Afara, Isaac O; Sarin, Jaakko K; Ojanen, Simo; Finnilä, Mikko A J; Herzog, Walter; Saarakkala, Simo; Korhonen Rami K; Töyräs, Juha. 2020. Cellular and molecular bioengineering. 13: 219-228 A1 Journal article (refereed), original research

Mid-infrared and Near infrared spectroscopic analysis of mechanically and enzymatically damaged cartilage

Nippolainen, Ervin; Shaikh, Rubina; Virtanen, Vesa; Rieppo, Lassi; Afara, Isaac; Saarakkala, Simo; Töyräs, Juha. 2020. Optical Society of America

Mid-infrared spectroscopic assessment of cartilage degeneration

Shaikh, Rubina; Nippolainen, Ervin; Virtanen, Vesa; Rieppo, Lassi; Haas, Julian; Mizaikoff, Boris; Artyushenko, Viacheslav; Bibikova, Olga; Afara, Isaac; Saarakkala, Simo; Töyräs, Juha. 2020. Optical Society of America

Near Infrared Spectroscopy Enables Differentiation of Mechanically and Enzymatically Induced Cartilage Injuries

Nippolainen, Ervin; Shaikh, Rubina; Virtanen, Vesa; Rieppo, Lassi; Saarakkala, Simo; Töyräs, Juha; Afara, Isaac. 2020. Annals of biomedical engineering. 48: 2343-2353 A1 Journal article (refereed), original research

Near-Infrared Spectroscopy for Mapping of Human Meniscus Biochemical Constituents

Ala-Myllymäki, Juho; Paakkonen, Tommi; Joukainen, Antti; Kröger, Heikki; Lehenkari, Petri; Töyräs, Juha; Afara, Isaac O. 2020. Annals of biomedical engineering. 2021; 49: 469-476 A1 Journal article (refereed), original research

Open-source python module for automated preprocessing of near infrared spectroscopic data

Torniainen, J; Afara, IO; Prakash, M; Sarin, JK; Stenroth, L; Töyräs, J. 2020. Analytica chimica acta. 1108: 1-9 A1 Journal article (refereed), original research

Optical properties of articular cartilage in the near-infrared spectral range are related to its proteoglycan content

Kafian-Attari, Iman; Semenov, Dmitry; Nippolainen, Ervin; Hauta-Kasari, Markku; Töyräs, Juha; Afara, Isaac O. Teoksessa: Tuchin, Valery V; Blondel, Walter CPM; Zalevsky, Zeev(toim.) , 2020. Proceedings Volume 11363, Tissue Optics and Photonics. s. 113630W. SPIE, The International Society for Optical Engineering A4 Conference proceedings

Polysomnographic characteristics of severe obstructive sleep apnea vary significantly between hypertensive and normotensive patients of both genders

Leppänen, T; Kulkas, A; Töyräs, J; Myllymaa, S; Gadoth, N; Oksenberg, A. 2020. Sleep and breathing. 2021; 25: 105-116 A1 Journal article (refereed), original research

Power spectral densities of nocturnal pulse oximetry signals differ in OSA patients with and without daytime sleepiness

Kainulainen, Samu; Töyräs, Juha; Oksenberg, Arie; Korkalainen, Henri; Afara, Isaac O; Leino, Akseli; Kalevo, Laura; Nikkonen, Sami; Gadoth, Natan; Kulkas, Antti; Myllymaa, Sami; Leppänen, Timo. 2020. Sleep medicine. 73: 231-237 A1 Journal article (refereed), original research

Quantification of Myocardial Blood Flow by Machine Learning Analysis of Modified Dual Bolus MRI Examination

Husso, Minna; Afara, Isaac O; Nissi, Mikko J; Kuivanen, Antti; Halonen, Paavo; Tarkia, Miikka; Teuho, Jarmo; Saunavaara, Virva; Vainio, Pauli; Sipola, Petri; Manninen, Hannu; Ylä-Herttuala, Seppo; Knuuti, Juhani; Töyräs, Juha. 2020. Annals of biomedical engineering. 2021; 49: 653-662 A1 Journal article (refereed), original research

Rapid CT-based Estimation of Articular Cartilage Biomechanics in the Knee Joint Without Cartilage Segmentation

Mohammadi, Ali; Myller, Katariina A H; Tanska, Petri; Hirvasniemi, Jukka; Saarakkala, Simo; Töyräs, Juha; Korhonen, Rami K; Mononen, Mika E. 2020. Annals of biomedical engineering. 48: 2965-2975 A1 Journal article (refereed), original research

Severe Desaturations Increase PVT-based Median Reaction Time and Number of Lapses in OSA Patients

Kainulainen, S; Duce, B; Korkalainen, H; Oksenberg, A; Leino, A; Arnardottir, E; Kulkas, A; Myllymaa, S; Töyräs, J; Leppänen, T. 2020. European respiratory journal. 55: 1901849 A1 Journal article (refereed), original research

Structural, compositional, and functional effects of blunt and sharp cartilage damage on the joint: a 9-month equine groove model study

Te Moller, Nikae CR; Mohammadi, Ali; Plomp, Saskia; Serra Bragança, Filipe M; Beukers, Martijn; Pouran, Behdad; Afara, Isaac O; Nippolainen, Ervin; Mäkelä, Janne TA; Korhonen, Rami K; Töyräs, Juha; Brommer, Harold; René van Weeren, P. 2020. Journal of orthopaedic research. 2021; 39: 2363-2375 A1 Journal article (refereed), original research

Tailored Synthesis of PEGylated Bismuth Nanoparticles for X-ray Computed Tomography and Photothermal Therapy: One-Pot, Targeted Pyrolysis, and Self-Promotion

Xu, Wujun; Cui, Pang; Happonen, Emilia; Leppänen, Jukka; Liu, Lizhi; Rantanen, Jimi; Majda, Dorota; Saukko, Annina; Thapa, Rinez; Nissinen, Tuomo; Tynkkynen, Tuulia; Töyräs, Juha; Fan, Li; Liu, Wenchao; Lehto, Vesa-Pekka. 2020. Acs applied materials and interfaces. 12: 47233-47244 A1 Journal article (refereed), original research

Tissue optical properties combined with machine learning enables estimation of articular cartilage composition and functional integrity

Kafian-Attari, Iman; Nippolainen, Ervin; Semenov, Dmitry; Hauta-Kasari, Markku; Töyräs, Juha; Afara, Isaac O. 2020. Biomedical optics express. 11: 6480-6494 A1 Journal article (refereed), original research

Accurate Deep Learning-Based Sleep Staging in a Clinical Population with Suspected Obstructive Sleep Apnea

Korkalainen, Henri; Aakko, Juhani; Nikkonen, Sami; Kainulainen, Samu; Leino, Akseli; Duce, Brett; Afara, Isaac Oluwaseun; Myllymaa, Sami; Töyräs, Juha; Leppänen, Timo. 2019. IEEE journal of biomedical and health informatics. 24: 2073-2081 A1 Journal article (refereed), original research

Arthroscopic Determination of Cartilage Proteoglycan Content and Collagen Network Structure with Near-Infrared Spectroscopy

Sarin, JK; Nykänen, O; Tiitu, V; Mancini, IAD; Brommer, H; Visser, J; Malda, J; van Weeren, PR; Afara, IO; Töyräs, J. 2019. Annals of biomedical engineering. 47: 1815-1826 A1 Journal article (refereed), original research

Artificial neural network analysis of the oxygen saturation signal enables accurate diagnostics of sleep apnea

Nikkonen, S; Afara, IO; Leppänen, T; Töyräs, J. 2019. Scientific reports. 9: 13200 A1 Journal article (refereed), original research

Computational evaluation of altered biomechanics related to articular cartilage lesions observed in vivo

Myller, KAH; Korhonen, RK; Töyräs, J; Salo, J; Jurvelin, JS; Venäläinen, MS. 2019. Journal of orthopaedic research. 37: 1042-1051 A1 Journal article (refereed), original research

Contrast enhanced computed tomography for real-time quantification of glycosaminoglycans in cartilage tissue engineered constructs

Garcia, João P; Longoni, Alessia; Gawlitta, Debby; Rosenberg, Antoine J W P; Grinstaff, Mark W; Töyräs, Juha; Weinans, Harrie; Creemers, Laura B; Pouran, Behdad. 2019. Acta biomaterialia. 100: 202-212 A1 Journal article (refereed), original research

Dataset on equine cartilage near infrared spectra, composition, and functional properties

Sarin, JK; Torniainen, J; Prakash, M; Rieppo, L; Afara, IO; Töyräs, J. 2019. Scientific data. 6: 164 A1 Journal article (refereed), original research

Does Magnetic Resonance Imaging Provide Superior Reliability for Achilles and Patellar Tendon Cross-Sectional Area Measurements Compared with Ultrasound Imaging?

Stenroth, Lauri; Sefa, Sandra; Arokoski, Jari; Töyräs, Juha. 2019. Ultrasound in medicine and biology. 45: 3186-3198 A1 Journal article (refereed), original research

Effects of body mass on microstructural features of the osteochondral unit: A comparative analysis of 37 mammalian species

Mancini, IAD; Rieppo, L; Pouran, B; Afara, IO; Braganca, FMS; van Rijen, MHP; Kik, M; Weinans, H; Toyras, J; van Weeren, PR; Malda, J. 2019. Bone. 127: 664-673 A1 Journal article (refereed), original research

Imaging of Proteoglycan and Water Contents in Human Articular Cartilage with Full-Body CT Using Dual Contrast Technique

Honkanen, MKM; Matikka, H; Honkanen, JTJ; Bhattarai, A; Grinstaff, MW; Joukainen, A; Kröger, H; Jurvelin, JS; Töyräs, J. 2019. Journal of orthopaedic research. 37: 1059-1070 A1 Journal article (refereed), original research

Improved Sweat Artifact Tolerance of Screen-Printed EEG Electrodes by Material Selection-Comparison of Electrochemical Properties in Artificial Sweat

Kalevo, Laura; Miettinen, Tomi; Leino, Akseli; Kainulainen, Samu; Myllymaa, Katja; Toyras, Juha; Leppanen, Timo; Myllymaa, Sami. 2019. IEEE access. 7: 133237-133247 A1 Journal article (refereed), original research

Intra-night variation in apnea-hypopnea index affects diagnostics and prognostics of obstructive sleep apnea

Nikkonen, S; Töyräs, J; Mervaala, E; Myllymaa, S; Terrill, P; Leppänen, T. 2019. Sleep and breathing. 2020; 24: 379-386 A1 Journal article (refereed), original research

Mortality-risk-based apnea-hypopnea index thresholds for diagnostics of obstructive sleep apnea

Korkalainen, H; Töyräs, J; Nikkonen, S; Leppänen, T. 2019. Journal of sleep research. 28: e12855 A1 Journal article (refereed), original research

Near infrared spectroscopy enables quantitative evaluation of human cartilage biomechanical properties during arthroscopy

Prakash, M; Joukainen, A; Torniainen, J; Honkanen, MKM; Rieppo, L; Afara, IO; Kröger, H; Töyräs, J; Sarin, JK. 2019. Osteoarthritis and cartilage. 27: 1235-1243 A1 Journal article (refereed), original research

Polysomnographic scoring of sleep bruxism events is accurate even in the absence of video recording but unreliable with EMG-only setups

Miettinen, T; Myllymaa, K; Muraja-Murro, A; Westeren-Punnonen, S; Hukkanen, T; Töyräs, J; Lappalainen, R; Mervaala, E; Sipilä, K; Myllymaa, S. 2019. Sleep and breathing. [First Online: 12 August 2019]: 1-12 A1 Journal article (refereed), original research

Prevalence and characteristics of positional obstructive sleep apnea (POSA) in patients with severe OSA

Oksenberg, A; Gadoth, N; Töyräs, J; Leppänen, T. 2019. Sleep and breathing. 2020; 24: 551-559 A1 Journal article (refereed), original research

Quantification of porcine myocardial perfusion with modified dual bolus MRI - a prospective study with a PET reference

Husso, M; Nissi, MJ; Kuivanen, A; Halonen, P; Tarkia, M; Teuho, J; Saunavaara, V; Vainio, P; Sipola, P; Manninen, H; Ylä-Herttuala, S; Knuuti, J; Töyräs, J. 2019. Bmc medical imaging. 19: 58 A1 Journal article (refereed), original research

Severity of desaturations reflects OSA-related daytime sleepiness better than AHI

Kainulainen, S; Töyräs, J; Oksenberg, A; Korkalainen, H; Sefa, S; Kulkas, A; Leppänen, T. 2019. Journal of clinical sleep medicine. 15: 1135-1142 A1 Journal article (refereed), original research

Simultaneous Quantitation of Cationic and Non-ionic Contrast Agents in Articular Cartilage Using Synchrotron MicroCT Imaging

Saukko, AEA; Turunen, MJ; Honkanen, MKM; Lovric, G; Tiitu, V; Honkanen, JTJ; Grinstaff, MW; Jurvelin, JS; Töyräs, J. 2019. Scientific reports. 9: 7118 A1 Journal article (refereed), original research

Synchrotron microCT reveals the potential of the dual contrast technique for quantitative assessment of human articular cartilage composition

Honkanen, MKM; Saukko, AEA; Turunen, MJ; Shaikh, R; Prakash, M; Lovric, G; Joukainen, A; Kröger, H; Grinstaff, MW; Töyräs, J. 2019. Journal of orthopaedic research. 2020; 38: 563-573 A1 Journal article (refereed), original research

T2* and quantitative susceptibility mapping in an equine model of post-traumatic osteoarthritis: assessment of mechanical and structural properties of articular cartilage

Nykänen, O; Sarin, JK; Ketola, JH; Leskinen, H; te Moller, NCR; Tiitu, V; Mancini, IAD; Visser, J; Brommer, H; van Weeren, P René; Malda, J; Töyräs, J; Nissi, MJ. 2019. Osteoarthritis and cartilage. 27: 1481-1490 A1 Journal article (refereed), original research

The hypoxic burden: also known as the desaturation severity parameter

Leppänen, Timo; Kulkas, Antti; Töyräs, Juha. 2019. European heart journal. 40: 2991-2993 B1 Non-refereed journal articles

Triple Contrast CT Method Enables Simultaneous Evaluation of Articular Cartilage Composition and Segmentation

Honkanen, MKM; Saukko, AEA; Turunen, MJ; Xu, W; Lovric, G; Honkanen, JTJ; Grinstaff, MW; Lehto, VP; Töyräs, J. 2019. Annals of biomedical engineering. 2020; 48: 556-567 A1 Journal article (refereed), original research

Accounting for spatial dependency in multivariate spectroscopic data

Prakash, M; Sarin, JK; Rieppo, L; Afara IO; Töyräs, J. 2018. Chemometrics and intelligent laboratory systems. 182: 166-171 A1 Journal article (refereed), original research

Arthroscopic near infrared spectroscopy enables simultaneous quantitative evaluation of articular cartilage and subchondral bone in vivo

Sarin, Jaakko K; Te Moller, Nikae CR; Mancini, Irina AD; Brommer, Harold; Visser, Jetze; Malda, Jos; van Weeren, PR; Afara, Isaac O; Töyräs, Juha. 2018. Scientific reports. 8: 13409 A1 Journal article (refereed), original research

Bayesian Network Model to Evaluate the Effectiveness of Continuous Positive Airway Pressure Treatment of Sleep Apnea

Ryynänen, Olli-Pekka; Leppänen, Timo; Kekolahti, Pekka; Mervaala, Esa; Töyräs, Juha. 2018. Healthcare informatics research. 24: 346-358 A1 Journal article (refereed), original research

Characterizing human subchondral bone properties using near-infrared (NIR) spectroscopy

Afara, IO; Florea, C; Olumegbon, IA; Eneh, CT; Malo, MKH; Korhonen, RK; Töyräs, J. 2018. Scientific reports. 8: 9733 A1 Journal article (refereed), original research

Comparison between kinetic and kinetic-kinematic driven knee joint finite element models

Bolcos, PO; Mononen, ME; Mohammadi, A; Ebrahimi, M; Tanaka, MS; Samaan, MA; Souza, RB; Li, X; Suomalainen, JS; Jurvelin, JS; Töyräs, J; Korhonen, RK. 2018. Scientific reports. 8: 17351 A1 Journal article (refereed), original research

Deep Learning Classification of Cartilage Integrity Using Near Infrared Spectroscopy

Afara, Isaac O.; Sarin, Jaakko K.; Ojanen, Simo; Finnilä, Mikko; Herzog, Walter; Saarakkala, Simo; Korhonen, Rami; Töyräs, Juha. 2018.

Differences in arousal probability and duration after apnea and hypopnea events in adult obstructive sleep apnea patients

Leppänen, Timo; Kulkas, Antti; Oksenberg, Arie; Duce, Brett; Mervaala, Esa; Töyräs, Juha. 2018. Physiological measurement. 39: 114004 A1 Journal article (refereed), original research

Estimating Mechanical Properties of Bovine Knee Ligaments and Tendons with Near Infrared Spectroscopy

Torniainen, Jari E; Ristaniemi, Aapo; Stenroth, Lauri; Töyräs, Juha. 2018. OSA Publishing

Home Polysomnography Reveals a First-Night Effect in Patients With Low Sleep Bruxism Activity

Miettinen, Tomi; Myllymaa, Katja; Hukkanen, Taina; Töyräs, Juha; Sipilä, Kirsi; Myllymaa, Sami. 2018. Journal of clinical sleep medicine. 14: 1377-1386 A1 Journal article (refereed), original research

Increase in Body Mass Index Decreases Duration of Apneas and Hypopneas in Obstructive Sleep Apnea

Leppänen, Timo; Kulkas, Antti; Mervaala, Esa; Töyräs, Juha. 2018. Respiratory care. 2019; 64: 77-84 A1 Journal article (refereed), original research

Method for Segmentation of Knee Articular Cartilages Based on Contrast-Enhanced CT Images

Myller, Katariina AH; Honkanen, Juuso TJ; Jurvelin, Jukka S; Saarakkala, Simo; Töyräs, Juha; Väänänen, Sami P. 2018. Annals of biomedical engineering. 46: 1756-1767 A1 Journal article (refereed), original research

Multi-scale imaging techniques to investigate solute transport across articular cartilage

Pouran, Behdad; Arbabi, Vahid; Bajpayee, Ambika G; van Tiel, Jasper; Töyras, Juha; Jurvelin, Jukka S; Malda, Jos; Zadpoor, Amir A; Weinans, Harrie. 2018. Journal of biomechanics. 78: 10-20 A2 Review article, Literature review, Systematic review

Near Infrared Spectroscopic Evaluation of Ligament and Tendon Biomechanical Properties

Torniainen, Jari; Ristaniemi, Aapo; Sarin, Jaakko K; Mikkonen, Santtu; Afara, Isaac O; Stenroth, Lauri; Korhonen, Rami K; Töyräs, Juha. 2018. Annals of biomedical engineering. 2019; 47: 213-222 A1 Journal article (refereed), original research

Near-infrared spectroscopy based arthroscopic evaluation of human knee joint cartilage, through automated selection of an anatomically specific regression model

Prakash, Mithilesh; Joukainen, Antti; Sarin, Jaakko; Rieppo, Lassi; Afara, Isaac; Töyräs, Juha. Teoksessa: -(toim.) , 2018. Optical Tomography and Spectroscopy 2018. s. OF4D.3. Optical Society of America B3 Non-refereed conference proceedings

Near-infrared spectroscopy: A potential tool for mapping meniscus properties

Ala-Myllymäki, Juho P.; Töyräs, Juha; Afara, Isaac O.. 2018. OSA Publishing

Quantitative Dual Contrast CT Technique for Evaluation of Articular Cartilage Properties

Bhattarai, A; Honkanen, JTJ; Myller, KAH; Prakash, M; Korhonen M; Saukko, AEA; Virén, T; Joukainen, A; Patwa, AN; Kröger, H; Grinstaf, MW; Jurvelin, JS; Töyräs, J;. 2018. Annals of biomedical engineering. 46: 1038-1046 A1 Journal article (refereed), original research

Quantitative susceptibility mapping of articular cartilage: Ex vivo findings at multiple orientations and following different degradation treatments

Nykänen, O; Rieppo, L; Töyräs, J; Kolehmainen, V; Saarakkala, S; Shmueli, K; Nissi, MJ. 2018. Magnetic resonance in medicine. 80: 2702-2716 A1 Journal article (refereed), original research

Required CPAP usage time to normalize AHI in obstructive sleep apnea patients: a simulation study

Kulkas, Antti; Leppänen, Timo; Nikkonen, Sami; Oksenberg, Arie; Duce, Brett; Mervaala, Esa; Töyräs, Juha. 2018. Physiological measurement. 39: 115009 A1 Journal article (refereed), original research

Simulation of Required CPAP Usage to Normalize AHI in Obstructive Sleep Apnea Patients

Kulkas, Antti; Nikkonen, Sami; Töyräs, Juha; Mervaala, Esa; Leppänen, Timo. Teoksessa: Lhotska, L; Sukupova, L; Lackovic, I; Ibbott, G(toim.) , 2018. World Congress on Medical Physics and Biomedical Engineering 2018, June 3-8, 2018, Prague, Czech Republic (Vol.2). s. 129-132. Springer A4 Conference proceedings

Spectroscopic Evaluation of Post-Traumatic Osteoarthritis in Shetland Ponies

Sarin, Jaakko K; te Moller, Nikae; Brommer, Harold; van Weeren, René; Mancini, Irina; Malda, Josa; Afara, Isaac O; Töyräs, Juha. Teoksessa: -(toim.) , 2018. Optical Tomography and Spectroscopy 2018. s. OTu4D.5. Optical Society of America B3 Non-refereed conference proceedings

At-home quantification of sleep characteristics with self-applicable facial electrode set

Miettinen T, Myllymaa K, Westeren-Punnonen S, Ahlberg J, Hukkanen T, Töyräs J, Lappalainen R, Mervaala E, Sipilä K, Myllymaa S. 2017. Sleep medicine. 40: e233-e234 A1 Journal article (refereed), original research

Combination of optical coherence tomography and near infrared spectroscopy enhances determination of articular cartilage composition and structure

Sarin Jaakko K, Rieppo Lassi, Brommer Harold, Afara Isaac O, Saarakkala Simo, Töyräs Juha. 2017. Scientific reports. 7: 10586 A1 Journal article (refereed), original research

Corrigendum to "Multimodality scoring of chondral injuries in the equine fetlock joint ex vivo" [Osteoarthritis Cartilage 25 (5) (2017 May) 790-798].

Sarin JK, Brommer H, Argüelles D, Puhakka PH, Inkinen SI, Afara IO, Saarakkala S, Töyräs J. 2017. Osteoarthritis and cartilage. 25: 1377-1378 A1 Journal article (refereed), original research

Dual Contrast CT Method Enables Diagnostics of Cartilage Injuries and Degeneration Using a Single CT Image

Saukko Annina EA, Honkanen Juuso TJ, Xu Wujun, Väänänen Sami P, Jurvelin Jukka S, Lehto Vesa-Pekka, Töyräs Juha. 2017. Annals of biomedical engineering. 45: 2857-2866 A1 Journal article (refereed), original research

Gender differences in severity of desaturation events following hypopnea and obstructive apnea events in adults during sleep

Kulkas Antti, Duce Brett, Leppänen Timo, Hukins Craig, Töyräs Juha. 2017. Physiological measurement. 38: 1490-1502 A1 Journal article (refereed), original research

Infrared microspectroscopic determination of collagen cross-links in articular cartilage

Rieppo L, Kokkonen HT, Kulmala KAM, Kovanen V, Lammi MJ, Töyräs J, Saarakkala S. 2017. Journal of biomedical optics. 22: 35007 A1 Journal article (refereed), original research

Infrared thermography reveals effect of working posture on skin temperature in office workers

Lasanen, R; Malo, MKH; Airaksinen, O; Karhu, J; Töyräs, J; Julkunen, P. 2017. International journal of occupational safety and ergonomics. 2018; 24: 457-463 A1 Journal article (refereed), original research

Multimodality scoring of chondral injuries in the equine fetlock joint ex vivo

Sarin Jaakko Kalevi, Brommer Harold, Argüelles David, Puhakka Pia Henriikka, Inkinen Satu Irene, Afara Isaac Oluwaseun, Saarakkala Simo, Töyräs Juha. 2017. Osteoarthritis and cartilage. 25: 790-798 A1 Journal article (refereed), original research

New approach for determining cartilage pore size distribution: NaCl-thermoporometry

Majda D, Bhattarai A, Riikonen J, Napruszewska BD, Zimowska M, Michalik-Zym A, Töyräs J, Lehto V-P. 2017. Microporous and mesoporous materials. 241: 238-245 A1 Journal article (refereed), original research

Optical spectroscopic characterization of human meniscus biomechanical properties

Ala-Myllymäki Juho, Danso Elvis K, Honkanen Juuso TJ, Korhonen Rami K, Töyräs J, Afara Isaac O. 2017. Journal of biomedical optics. 22: 125008 (10 pages) A1 Journal article (refereed), original research

Optimal Regression Method for Near-Infrared Spectroscopic Evaluation of Articular Cartilage

Prakash M, Sarin JK, Rieppo L, Afara IO, Töyräs J. 2017. Applied spectroscopy. 71: 2253-2262 A1 Journal article (refereed), original research

Peri-apneic hemodynamic reactions in obstructive sleep apnea

Muraja-Murro Anu, Nieminen Outi, Julkunen Petro, Töyräs Juha, Laitinen Tomi, Mervaala Esa. 2017. Pathophysiology. 24: 197-203 A1 Journal article (refereed), original research

Porosity predicted from ultrasound backscatter using multivariate analysis can improve accuracy of cortical bone thickness assessment

Eneh Chibuzor TM, Afara Isaac O, Malo Markus KH, Jurvelin Jukka S, Töyräs Juha. 2017. Journal of the acoustical society of america. 141: 575-585 A1 Journal article (refereed), original research

Regular chondrocyte spacing is a potential cause for coherent ultrasound backscatter in human articular cartilage

Rohrbach D, Inkinen SI, Zatloukalová J, Kadow-Romacker A, Joukainen A, Malo MK, Mamou J, Töyräs J, Raum K. 2017. Journal of the acoustical society of america. 141: 3105-3116 A1 Journal article (refereed), original research

Screen-printed ambulatory electrode set enables accurate diagnostics of sleep bruxism

Miettinen T, Myllymaa K, Muraja-Murro A, Westeren-Punnonen S, Hukkanen T, Töyräs J, Lappalainen R, Mervaala E, Sipilä K, Myllymaa S. 2017. Journal of sleep research. 2018; 27: 103-112 A1 Journal article (refereed), original research

Severity of desaturation events differs between hypopnea and obstructive apnea events and is modulated by their duration in obstructive sleep apnea

Kulkas Antti, Duce Brett, Leppänen Timo, Hukins Craig, Töyräs Juha. 2017. Sleep and breathing. 21: 829-835 A1 Journal article (refereed), original research

Severity of individual obstruction events increases with age in patients with obstructive sleep apnea

Leppänen Timo, Töyräs Juha, Mervaala Esa, Penzel Thomas, Kulkas Antti. 2017. Sleep medicine. 37: 32-37 A1 Journal article (refereed), original research

Success Rate and Technical Quality of Home Polysomnography with Self-Applicable Electrode Set in Subjects with Possible Sleep Bruxism

Miettinen T, Myllymaa K, Westeren-Punnonen S, Ahlberg J, Hukkanen T, Töyräs J, Lappalainen R, Mervaala E, Sipilä K, Myllymaa S. 2017. IEEE journal of biomedical and health informatics. 120; 22: 1124-1132 A1 Journal article (refereed), original research

The prevalence of REM-related obstructive sleep apnoea is reduced by the AASM 2012 hypopnoea criteria

Duce Brett, Kulkas Antti, Langton Christian, Töyräs Juha, Hukins Craig. 2017. Sleep and breathing. 2018; 22: 57-64 A1 Journal article (refereed), original research

Tissue viscoelasticity is related to tissue composition but may not fully predict the apparent-level viscoelasticity in human trabecular bone - An experimental and finite element study

Ojanen X, Tanska P, Malo MKH, Isaksson H, Väänänen SP, Koistinen AP, Grassi L, Magnusson SP, Ribel-Madsen SM, Korhonen RK, Jurvelin JS, Töyräs J. 2017. Journal of biomechanics. 65: 96-105 A1 Journal article (refereed), original research

Ultrasound Arthroscopy of Hip in Treatment of Osteochondritis Dissecans

Joukainen A, Virén T, Penttilä P, Liukkonen J, Puhakka PH, Kröger H, Töyräs J. 2017. Arthroscopy techniques. 6: e1063-e1068 A1 Journal article (refereed), original research

Ultrasound Assessment of Human Meniscus

Viren T, Honkanen JT, Danso EK, Rieppo L, Korhonen RK, Töyräs J. 2017. Ultrasound in medicine and biology. 43: 1753-1763 A1 Journal article (refereed), original research

Amsterdam positional OSA classification: the AASM 2012 recommended hypopnoea criteria increases the number of positional therapy candidates

Duce B, Kulkas A, Langton C, Töyräs J, Hukins C. 2016. Sleep and breathing. First Online: 11 November 2016: 1-7 A1 Journal article (refereed), original research

Assessment of the suitability of using a forehead EEG electrode set and chin EMG electrodes for sleep staging in polysomnography

Myllymaa Sami, Muraja-Murro Anu, Westeren-Punnonen Susanna, Hukkanen Taina, Lappalainen Reijo, Mervaala Esa, Töyräs Juha, Sipilä Kirsi, Myllymaa Katja. 2016. Journal of sleep research. [Epub ahead of print 27 May 2016]: 1-10 A1 Journal article (refereed), original research

Cationic Contrast Agent Diffusion Differs Between Cartilage and Meniscus

Honkanen Juuso TJ, Mikael J, Freedman Jonathan D, Saarakkala Simo, Grinstaff Mark W, Ylärinne Janne H, Jurvelin Jukka S, Töyräs Juha. 2016. Annals of biomedical engineering. 44: 2913-2921 A1 Journal article (refereed), original research

Contrast-Enhanced Computed Tomography Enables Quantitative Evaluation of Tissue Properties at Intrajoint Regions in Cadaveric Knee Cartilage

Stewart Rachel C, Honkanen Juuso TJ, Kokkonen Harri T, Tiitu Virpi, Saarakkala Simo, Joukainen Antti, Snyder Brian D, Jurvelin Jukka S, Grinstaff Mark W, Töyräs Juha. 2016. Cartilage. 8: 391-399 A1 Journal article (refereed), original research

Differences in acoustic impedance of fresh and embedded human trabecular bone samples - scanning acoustic microscopy and numerical evaluation

Ojanen X, Töyräs J, Inkinen SI, Malo MKH, Isaksson H, Jurvelin JS. 2016. Journal of the acoustical society of america. 140: 1931-1936 A1 Journal article (refereed), original research

Effect of bone inhomogeneity on tibiofemoral contact mechanics during physiological loading

Venäläinen MS, Mononen ME, Väänänen SP, Jurvelin JS, Töyräs J, Virén T, Korhonen RK. 2016. Journal of biomechanics. 7: 1111-1120 A1 Journal article (refereed), original research

Effect of collagen cross-linking on quantitative MRI parameters of articular cartilage

Rautiainen J, Nieminen MT, Salo EN, Kokkonen HT, Mangia S, Michaeli S, Gröhn O, Jurvelin JS, Töyräs J, Nissi MJ. 2016. Osteoarthritis and cartilage. 24: 1656-1664 A1 Journal article (refereed), original research

Effect of porosity, tissue density, and mechanical properties on radial sound speed in human cortical bone

Eneh CTM, Malo MKH, Karjalainen JP, Liukkonen J, Töyräs J, Jurvelin JS. 2016. Medical physics. 43: 2030-2039 A1 Journal article (refereed), original research

Estimation of Systematic and Spatially Correlated Components of Random Signals from Repeated Measurements: Application to Contrast Enhanced Computer Tomography Measurements

Huttunen JMJ, Turunen MJ, Honkanen JTJ, Töyräs J, Jurvelin JS. 2016. Siam journal on scientific computing. 38: B77-B99 A1 Journal article (refereed), original research

Finite difference time domain model of ultrasound propagation in agarose scaffold containing collagen or chondrocytes

Inkinen SI, Liukkonen J, Malo MK, Virén T, Jurvelin JS, Töyräs J. 2016. Journal of the acoustical society of america. 140: 1 A1 Journal article (refereed), original research

Importance of patella, quadriceps forces, and depthwise cartilage structure on knee joint motion and cartilage response during gait

Halonen KS, Mononen ME, Jurvelin JS, Töyräs J, Klodowski A, Kulmala JP, Korhonen RK. 2016. Journal of biomechanical engineering: transactions of the ASME. 138: BIO-15-1348, 11 pages A1 Journal article (refereed), original research

In Vivo Contrast-Enhanced Cone Beam CT Provides Quantitative Information on Articular Cartilage and Subchondral Bone

Myller Katariina AH, Turunen Mikael J, Honkanen Juuso TJ, Väänänen Sami P, Iivarinen Jarkko T, Salo Jari, Jurvelin Jukka S, Töyräs Juha. 2016. Annals of biomedical engineering. [Epub ahead of print 19 Sept 2016]: 1-8 A1 Journal article (refereed), original research

Length of Individual Apnea Events Is Increased by Supine Position and Modulated by Severity of Obstructive Sleep Apnea

Leppänen Timo, Töyräs Juha, Muraja-Murro Anu, Kupari Salla, Tiihonen Pekka, Mervaala Esa, Kulkas Antti. 2016. Sleep disorders. 2016: 1-13 A1 Journal article (refereed), original research

Near Infrared Spectroscopic Mapping of Functional Properties of Equine Articular Cartilage

Sarin Jaakko K, Amissah Michael, Brommer Harold, Argüelles David, Töyräs Juha, Afara Isaac O. 2016. Annals of biomedical engineering. 44: 3335-3345 A1 Journal article (refereed), original research

Optical coherence tomography enables accurate measurement of equine cartilage thickness for determination of speed of sound

Puhakka PH, te Moller NCR, Tanska P, Saarakkala S, Tiitu V, Korhonen RK, Brommer H, Virén T, Jurvelin JS, Töyräs J. 2016. Acta orthopaedica. 87: 418-424 A1 Journal article (refereed), original research

Optimal graft stiffness and pre-strain restore normal joint motion and cartilage responses in ACL reconstructed knee

Halonen KS, Mononen ME, Töyräs J, Kröger H, Joukainen A, Korhonen RK. 2016. Journal of biomechanics. 49: 2566-2576 A1 Journal article (refereed), original research

Phased-array ultrasound technology enhances accuracy of dual frequency ultrasound measurements - towards improved ultrasound bone diagnostics

Linder H, Malo MK, Liukkonen J, Jurvelin JS, Töyräs J. 2016. Journal of medical engineering and technology. 40: 293-297 A1 Journal article (refereed), original research

Quantitative Evaluation of the Mechanical Risks Caused by Focal Cartilage Defects in the Knee

Venäläinen Mikko S, Mononen Mika E, Salo Jari, Räsänen Lasse P, Jurvelin Jukka S, Töyräs Juha, Virén Tuomas, Korhonen Rami K. 2016. Scientific reports. 6: 37538 A1 Journal article (refereed), original research

RemLogic plug-in enables clinical application of apnea-hypopnea index adjusted for severity of individual obstruction events

Leppänen Timo, Särkkä Mikko, Kulkas Antti, Muraja-Murro Anu, Kupari Salla, Anttonen Meri, Tiihonen Pekka, Mervaala Esa, Töyräs Juha. 2016. Journal of medical engineering and technology. 40: 119-126 A1 Journal article (refereed), original research

Semi-automated International Cartilage Repair Society scoring of equine articular cartilage lesions in optical coherence tomography images

Te Moller NC, Pitkänen M, Sarin JK, Väänänen S, Liukkonen J, Afara IO, Puhakka PH, Brommer H, Niemelä T, Tulamo RM, Arqüelles Capilla D, Töyräs J. 2016. Equine veterinary journal. [Epub ahead of print 20 Oct 2016]: - A1 Journal article (refereed), original research

Severity of individual obstruction events is gender dependent in sleep apnea

Leppänen Timo, Kulkas Antti, Duce Brett, Mervaala Esa, Töyräs Juha. 2016. Sleep and breathing. First Online: 13 December 2016: 1-8 A1 Journal article (refereed), original research

Solute transport of negatively charged contrast agents across articular surface of injured cartilage

Kokkonen HT, Chin HC, Töyräs J, Jurvelin JS, Quinn TM. 2016. Annals of biomedical engineering. First Online: 08 November 2016: 1-9 A1 Journal article (refereed), original research

Species-Independent Modeling of High-Frequency Ultrasound Backscatter in Hyaline Cartilage

Männicke Nils, Schöne Martin, Liukkonen Jukka, Fachet Dominik, Inkinen Satu, Malo Markus K, Oelze Michael L, Töyräs Juha, Jurvelin Jukka S, Raum Kay. 2016. Ultrasound in medicine and biology. 42: 1375-1384 A1 Journal article (refereed), original research

Structure-function relationships of human meniscus

Danso EK, Oinas JM, Saarakkala S, Mikkonen S, Töyräs J, Korhonen RK. 2016. Journal of the mechanical behavior of biomedical materials. 67: 51-60 A1 Journal article (refereed), original research

The AASM 2012 recommended hypopnea criteria increase the incidence of obstructive sleep apnea but not the proportion of positional obstructive sleep apnea

Duce B, Kulkas A, Langton C, Töyräs J, Hukins C. 2016. Sleep medicine. 26: 23-29 A1 Journal article (refereed), original research

Vibrational spectroscopy of articular cartilage

Rieppo Lassi, Töyräs Juha, Saarakkala Simo. 2016. Applied spectroscopy reviews. [Published online 23 Aug 2016]: 1-18 A2 Review article, Literature review, Systematic review

A Handy EEG Electrode Set for patients suffering from altered mental state

Lepola Pasi, Myllymaa Sami, Töyräs Juha, Hukkanen Taina, Mervaala Esa, Määttä Sara, Lappalainen Reijo Myllymaa Katja. 2015. Journal of clinical monitoring and computing. 29: 697-705 A1 Journal article (refereed), original research

Amount of weight loss or gain influences the severity of respiratory events in sleep apnea

Kulkas A, Leppänen T, Sahlman J, Tiihonen P, Mervaala E, Kokkarinen J, Randell J, Seppä J, Töyräs J, Tuomilehto H. 2015. Medical and biological engineering and computing. epub 17 Apr 2015: 14 p A1 Journal article (refereed), original research

Articular cartilage repair with recombinant human type II collagen/polylactide scaffold in a preliminary porcine study

Muhonen Virpi, Salonius Eve, Haaparanta Anne-Marie, Järvinen Elina, Paatela Teemu, Meller Anna, Hannula Markus, Björkman Mimmi, Pyhältö Tuomo, Ellä Ville, Vasara Anna, Töyräs Juha, Kellomäki Minna, Kiviranta Ilkka. 2015. Journal of orthopaedic research. 2016; 34: 745-753 A1 Journal article (refereed), original research

Characterization of site-specific biomechanical properties of human meniscus-Importance of collagen and fluid on mechanical nonlinearities

Danso EK, Mäkelä JTA, Tanska P, Mononen ME, Honkanen JTJ, Jurvelin JS, Töyräs J, Julkunen P, Korhonen RK. 2015. Journal of biomechanics. 48: 1499-1507 A1 Journal article (refereed), original research

Comparison of subchondral bone density and structure of tibia measured from plain radiograph with micro-computed tomography

Hirvasniemi J., Kokkonen H. T., Thevenot J., Finnilä M., Venäläinen M. S., Jämsä T., Korhonen R. K., Töyräs J., Saarakkala S.. 2015. Osteoarthritis and cartilage

Contrast Enhanced Imaging of Human Meniscus Using Cone Beam CT

Honkanen JTJ, Danso EK, Suomalainen JS, Tiitu V, Korhonen RK, Jurvelin JS, Töyräs J. 2015. Osteoarthritis and cartilage. 23: 1367-1376 A1 Journal article (refereed), original research

Correlation of Subchondral Bone Density and Structure from Plain Radiographs with Micro Computed Tomography Ex Vivo

Hirvasniemi Jukka, Thevenot Jérôme, Kokkonen Harri T, Finnilä Mikko A, Venäläinen Mikko S, Jämsä Timo, Korhonen Rami K, Töyräs Juha, Saarakkala Simo. 2015. Annals of biomedical engineering. 44: 1698 A1 Journal article (refereed), original research

Diagnosis of Knee Osteochondral Lesions With Ultrasound Imaging

Penttilä Pekko, Liukkonen Jukka, Joukainen Antti, Virén Tuomas, Jurvelin Jukka S, Töyräs Juha, Kröger Heikki. 2015. Arthroscopy techniques. 4: e429-e433 A1 Journal article (refereed), original research

Effect of different oxygen desaturation threshold levels on hypopnea scoring and classification of severity of sleep apnea

Myllymaa Sami, Myllymaa Katja, Kupari Salla, Kulkas Antti, Leppänen Timo, Tiihonen Pekka, Mervaala Esa, Seppä Juha, Tuomilehto Henri, Töyräs Juha. 2015. Sleep and breathing. 19: 947-954 A1 Journal article (refereed), original research

Effect of oxygen desaturation threshold on determination of OSA severity during weight loss

Myllymaa Katja, Myllymaa Sami, Leppänen Timo, Kulkas Antti, Kupari Salla, Tiihonen Pekka, Mervaala Esa, Seppä Juha, Tuomilehto Henri, Töyräs Juha. 2015. Sleep and breathing. 2016; 20: 33-42 A1 Journal article (refereed), original research

Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal

Puhakka PH, Te Moller NC, Afara IO, Mäkelä JT, Tiitu V, Korhonen RK, Brommer H, Virén T, Jurvelin JS, Töyräs J. 2015. Osteoarthritis and cartilage. 23: 2206-2213 A1 Journal article (refereed), original research

Forehead EEG electrode set versus full-head scalp EEG in 100 patients with altered mental state

Muraja-Murro Anu, Mervaala Esa, Westeren-Punnonen Susanna, Lepola Pasi, Töyräs Juha, Myllymaa Sami, Julkunen Petro, Kantanen Anne-Mari, Kälviäinen Reetta, Myllymaa Katja. 2015. Epilepsy and behavior. 49: 245-249 A1 Journal article (refereed), original research

In Vivo Evaluation of the Potential of High-Frequency Ultrasound for Arthroscopic Examination of the Shoulder Joint

Puhakka Jani, Afara Isaac O, Paatela Teemu, Sormaala Markus J, Timonen Matti A, Virén Tuomas, Jurvelin Jukka S, Töyräs Juha, Kiviranta Ilkka. 2015. Cartilage. 2016; 7: 248-255 A1 Journal article (refereed), original research

Inter-individual changes in cortical bone three-dimensional microstructure and elastic coefficient have opposite effects on radial sound speed

Eneh Chibuzor TM, Liukkonen Jukka, Malo Markus KH, Jurvelin Jukka S, Töyräs Juha. 2015. Journal of the acoustical society of america. 138: 3491 A1 Journal article (refereed), original research

Menthol concentration in topical cold gel does not have significant effect on skin cooling

Lasanen R, Julkunen P, Airaksinen O, Töyräs J. 2015. Skin research and technology. 2016; 22: 40-45 A1 Journal article (refereed), original research

New method for point-of-care osteoporosis screening and diagnostics

Karjalainen JP, Riekkinen O, Töyräs J, Jurvelin JS, Kröger H. 2015. Osteoporosis international. 2016; 27: 971-977 A1 Journal article (refereed), original research

Optical absorption spectra of human articular cartilage correlate with biomechanical properties, histological score and biochemical composition

Afara Isaac O, Hauta-Kasari Markku, Jurvelin Jukka S, Oloyede Adekunle, Töyräs Juha. 2015. Physiological measurement. 36: 1913-1928 A1 Journal article (refereed), original research

Optical spectroscopic determination of human meniscus composition

Ala-Myllymäki Juho, Honkanen Juuso TJ, Töyräs Juha, Afara Isaac O. 2015. Journal of orthopaedic research. 2016; 34: 270-278 A1 Journal article (refereed), original research

Quantitative evaluation of knee subchondral bone mineral density using cone beam computed tomography

Turunen Mikael J, Töyräs Juha, Kokkonen Harri T, Jurvelin Jukka S. 2015. IEEE transactions on medical imaging. 34: 2186-2190 A1 Journal article (refereed), original research

Thermal imaging in screening of joint inflammation and rheumatoid arthritis in children

Lasanen R, Piippo-Savolainen E, Remes-Pakarinen T, Kröger L, Heikkilä A., Julkunen P., Karhu J, Töyräs J. 2015. Physiological measurement. 36: 273-282 A1 Journal article (refereed), original research

Transport of Iodine Is Different in Cartilage and Meniscus

Honkanen Juuso, Turunen Mikael, Tiitu Virpi, Jurvelin Jukka, Töyräs Juha. 2015. Annals of biomedical engineering. 2016; 44: 2114-2122 A1 Journal article (refereed), original research

Ultrasound Backscattering Is Anisotropic in Bovine Articular Cartilage

Inkinen Satu I, Liukkonen Jukka, Tiitu Virpi, Viren Tuomas, Jurvelin Jukka S, Töyräs Juha. 2015. Ultrasound in medicine and biology. 41: 1958-1966 A1 Journal article (refereed), original research

Adjustment of apnea-hypopnea index with severity of obstruction events enhances detection of sleep apnea patients with the highest risk of severe health consequences

Muraja-Murro A, Kulkas A, Hiltunen M, Kupari S, Hukkanen T, Tiihonen P, Mervaala E, Töyräs J. 2014. Sleep and breathing. 18: 641-647 A1 Journal article (refereed), original research

Application of optical coherence tomography enhances reproducibility of arthroscopic evaluation of equine joints

Niemelä Tytti, Virén Tuomas, Liukkonen Jukka, Argüelles David, te Moller Nikae CR, Puhakka Pia H, Jurvelin Jukka S, Tulamo Riitta-Mari, Töyräs Juha. 2014. Acta veterinaria Scandinavica. 56: - B1 Non-refereed journal articles

Arrangement and method for carrying out electrode measurements

Lappalainen R, Mervaala E, Myllymaa K, Myllymaa S, Töyräs J. 2014. H1 Granted patent

Assessment of myocardial perfusion with MRI using a modified dual bolus method

Husso M, Sipola P, Kuittinen T, Manninen H, Vainio P, Hartikainen J, Saarakkala S, Töyräs J, Kuikka J. 2014. Physiological measurement. 35: 533-47 A1 Journal article (refereed), original research

Collagen and chondrocyte concentrations control ultrasound scattering in agarose scaffolds

Inkinen Satu, Liukkonen Jukka, Ylärinne Janne, Puhakka Pia, Lammi Mikko, Virén Tuomas, Jurvelin Jukka, Töyräs Juha. 2014. Ultrasound in medicine and biology. 40: 2162-2171 A1 Journal article (refereed), original research

Deformation of articular cartilage during static loading of a knee joint - Experimental and finite element analysis

Halonen KS, Mononen ME, Jurvelin JS, Töyräs J, Salo J, Korhonen RK. 2014. Journal of biomechanics. 47: 2467-2474 A1 Journal article (refereed), original research

Dependence of light attenuation and backscattering on collagen concentration and chondrocyte density in agarose scaffolds

Puhakka PH, Ylärinne JH, Lammi MJ, Saarakkala S, Tiitu V, Kröger H, Virén T, Jurvelin JS, Töyräs J. 2014. Physics in medicine and biology. 59: 6537-48 A1 Journal article (refereed), original research

Effects of freeze-thaw cycle with and without proteolysis inhibitors and cryopreservant on the biochemical and biomechanical properties of articular cartilage

Qu Chengjuan, Hirviniemi Mikko, Tiitu Virpi, Jurvelin Jukka S, Töyräs Juha, Lammi Mikko J. 2014. Cartilage. 5: 97-106 A1 Journal article (refereed), original research

Estimation of fixed charge density and diffusivity profiles in cartilage using contrast enhanced computer tomography

Huttunen JMJ, Kokkonen HT, Jurvelin JS, Töyräs J, Kaipio JP. 2014. International journal for numerical methods in engineering. 98: 371-390 A1 Journal article (refereed), original research

Importance of Material Properties and Porosity of Bone on Mechanical Response of Articular Cartilage in Human Knee Joint - A Two-Dimensional Finite Element Study

Venäläinen Mikko S, Mononen Mika E, Jurvelin Jukka S, Töyräs Juha, Virén Tuomas, Korhonen Rami K. 2014. Journal of biomechanical engineering: transactions of the ASME. 136: 121005 A1 Journal article (refereed), original research

Morbidity and mortality risk ratios are elevated in severe supine dominant OSA: a long-term follow-up study

Kulkas A, Muraja-Murro A, Tiihonen P, Mervaala E, Töyräs J. 2014. Sleep and breathing. epub: 8 sivua A1 Journal article (refereed), original research

Relationships Between Tissue Composition and Viscoelastic Properties in Human Trabecular Bone

Ojanen X, Isaksson H, Töyräs J, Turunen MJ, Malo MKH, Halvari A, Jurvelin JS. 2014. Journal of biomechanics. : 269-275 A1 Journal article (refereed), original research

Screen-printed EEG electrode set for emergency use

Lepola Pasi, Myllymaa Sami, Töyräs Juha, Muraja-Murro Anu, Mervaala Esa, Lappalainen Reijo, Myllymaa Katja. 2014. Sensors and actuators a: physical. 213: 19-26 A1 Journal article (refereed), original research

Shielded design of screen-printed EEG electrode set reduces interference pick-up

Lepola Pasi, Myllymaa Sami, Töyräs Juha, Mervaala Esa, Lappalainen Reijo, Myllymaa Katja. 2014. IEEE sensors journal. 14: 2692-2697 A1 Journal article (refereed), original research

Ultrasound Arthroscopy of Human Knee Cartilage and Subchondral Bone in Vivo

Liukkonen Jukka, Lehenkari Petri, Hirvasniemi Jukka, Joukainen Antti, Virén Tuomas, Saarakkala Simo, Nieminen Miika T, Jurvelin Jukka S, Töyräs Juha. 2014. Ultrasound in medicine and biology. 40: 2039-2047 A1 Journal article (refereed), original research

Ultrasound backscatter measurements of intact human proximal femurs - Relationships of ultrasound parameters with tissue structure and mineral density

Malo MKH, Töyräs J, Karjalainen JP, Isaksson H, Riekkinen O, Jurvelin JS. 2014. Bone. 64: 240-245 A1 Journal article (refereed), original research

Weight loss alters severity of individual nocturnal respiratory events depending on sleeping position

Kulkas A, Leppänen T, Sahlman J, Tiihonen P, Mervaala E, Kokkarinen J, Randell J, Seppä J, Töyräs J, Tuomilehto H. 2014. Physiological measurement. 35: 2037-2052 A1 Journal article (refereed), original research

Arthroscopic optical coherence tomography provides detailed information on articular cartilage lesions in horses

te Moller, NCR; Brommer, H; Liukkonen, J; Virén T; Timonen M; Puhakka PH; Jurvelin JS; van Weeren PR; Töyräs J. 2013. Veterinary journal. 197: 589-595 B1 Non-refereed journal articles

Arthroscopic ultrasound technique for simultaneous quantitative assessment of articular cartilage and subchondral bone: an in vitro and in vivo feasibility study

Liukkonen J, Hirvasniemi J, Joukainen A, Penttilä P, Virén T, Saarakkala S, Kröger H, Jurvelin JS, Töyräs J. 2013. Ultrasound in medicine and biology. 39: 1460-1468 A1 Journal article (refereed), original research

Collagen and Chondrocyte Content Control Ultrasound Scattering in Agarose Scaffolds

Inkinen, S; Liukkonen, J; Ylärinne, Puhakka, PH; J; Lammi, M; Virén, T; Jurvelin JS; Töyräs, J. 2013.

Desaturation delay, parameter for evaluating severity of sleep disordered breathing

Kulkas A, Tiihonen P, Julkunen P, Mervaala E, Töyräs J. Teoksessa: Long M(toim.) , 2013. World Congress on Medical Physics and Biomedical Engineering May 26-31, 2012, Beijing, China. s. 336-339. Springer Gabler A3 Book section, Chapters in research books

Diffusion of ionic and non-ionic contrast agents in articular cartilage with increased cross-linking-contribution of steric and electrostatic effects

Kulmala KAM, Karjalainen HM, Kokkonen HT, Tiitu V, Kovanen V, Lammi MJ, Jurvelin JS, Korhonen RK, Töyräs J. 2013. Medical engineering and physics. 35: 1415-1420 A1 Journal article (refereed), original research

Importance of depth-wise distribution of collagen and proteoglycans in articular cartilage - A 3D finite element study of stresses and strains in human knee joint

Halonen KS, Mononen ME, Jurvelin JS, Töyräs J, Korhonen RK. 2013. Journal of biomechanics. 46: 1184-1192 A1 Journal article (refereed), original research

In vivo diagnostics of human knee cartilage lesions using delayed CBCT arthrography

Kokkonen HT, Suomalainen JS, Joukainen A, Kröger H, Sirola J, Jurvelin JS, Salo J, Töyräs J. 2013. Journal of orthopaedic research. 2013: 1-10 A1 Journal article (refereed), original research

Longitudinal elastic properties and porosity of cortical bone tissue vary with age in human proximal femur

Malo MK, Rohrbach D, Isaksson H, Töyräs J, Jurvelin JS, Tamminen IS, Kröger H, Raum K. 2013. Bone. 53: 451-458 A1 Journal article (refereed), original research

Mortality in middle-aged men with obstructive sleep apnea in Finland

Muraja-Murro A, Eskola K, Kolari T, Tiihonen P, Hukkanen T, Tuomilehto H, Peltonen M, Mervaala E, Töyräs J. 2013. Sleep and breathing. 17: 1047-1053 A1 Journal article (refereed), original research

New disposable forehead electrode set with excellent signal quality and imaging compatibility

Myllymaa Sami, Lepola Pasi, Töyräs Juha, Hukkanen Taina, Mervaala Esa, Lappalainen Reijo, Myllymaa Katja. 2013. Journal of neuroscience methods. 215: 103-109 A1 Journal article (refereed), original research

Novel parameters for evaluating severity of sleep disordered breathing and for supporting diagnosis of sleep apnea-hypopnea syndrome

Kulkas A, Tiihonen P, Eskola K, Julkunen P, Mervaala E, Töyräs J. 2013. Journal of medical engineering and technology. 37: 135-143 A1 Journal article (refereed), original research

Novel parameters indicate significant differences in severity of obstructive sleep apnea with patients having similar apnea-hypopnea index

Kulkas A, Tiihonen P, Julkunen P, Mervaala E, Töyräs J. 2013. Medical and biological engineering and computing. 51: 697-708 A1 Journal article (refereed), original research

Novel parameters reflect changes in morphology of respiratory events during weight loss

Kulkas A, Leppänen T, Sahlman J, Tiihonen P, Mervaala E, Kokkarinen J, Randell J, Seppä J, Tuomilehto H, Töyräs J. 2013. Physiological measurement. 34: 1013-1026 A1 Journal article (refereed), original research

Novel screen printed electrode set for routine EEG recordings in patients with altered mental status

Myllymaa S, Lepola P, Hukkanen T, Oun A, Mervaala E, Toyras J, Lappalainen R, Myllymaa K. Teoksessa: -(toim.) , 2013. Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE. s. 6724-6727. A4 Conference proceedings

Rustovaurioiden kehittyvä diagnostiikka - nopein hoitotuloksia parantava tekijä?

Salo J, Töyräs J, Joukainen A, Jurvelin J, Kröger H. 2013. Suomen Ortopedia ja Traumatologia. 36: 256-261 D1 Article in a trade journal

The severity of individual obstruction events is related to increased mortality rate in severe obstructive sleep apnea

Muraja-Murro A, Kulkas A, Hiltunen M, Kupari S, Hukkanen T, Tiihonen P, Mervaala E, Töyräs J. 2013. Journal of sleep research. 22: 663-669 A1 Journal article (refereed), original research

Ultrasound Arthroscopy of Human Knee Joint in vivo,

Liukkonen J, Lehenkari P, Hirvasniemi J, Joukainen A, Saarakkala S, Jurvelin J, Töyräs J. 2013.

Ultrasound Arthroscopy of Human Knee Joint: Feasibility In Vivo

Liukkonen J, Lehenkari P, Hirvasniemi J, Joukainen A, Virén T, Saarakkala S, Nieminen M, Jurvelin JS, Töyräs J. 2013.

Bath concentration of anionic contrast agents does not affect their diffusion and distribution in articular cartilage in vitro

Silvast Tuomo, Jurvelin Jukka, Tiitu Virpi, Quinn Thomas, Töyräs Juha. 2012. Cartilage. 2013; 4: 42-51 A1 Journal article (refereed), original research

Comparison of ultrasound and optical coherence tomography techniques for evaluation of integrity of spontaneously repaired horse cartilage

Virén T, Huang YP, Saarakkala S, Pulkkinen H, Tiitu V, Linjama A, Kiviranta I, Lammi MJ, Brünott A, Van Weeren R, Brama PAJ, Zheng YP, Jurvelin JS, Töyräs J. 2012. Journal of medical engineering and technology. 36: 185-192 A1 Journal article (refereed), original research

Contrast-Enhanced Micro-Computed Tomography in Evaluation of Spontaneous Repair of Equine Cartilage

K.A.M. Kulmala, H.J. Pulkkinen, L. Rieppo, V. Tiitu, I. Kiviranta, A. Brünott, H. Brommer, R. van Weeren, P.A.J. Brama, M.T. Mikkola, R.K. Korhonen, J.S. Jurvelin, J.Töyräs. 2012. Cartilage. 3: 235-244 A1 Journal article (refereed), original research

Delayed computed tomography artrography of human knee cartilage In Vivo

Kokkonen, Harri; Aula, Antti; Kröger, Heikki; Suomalainen, Juha-Sampo; Lammentausta, Eveliina; Mervaala, Esa; Jurvelin, Jukka; Töyräs, Juha. 2012. Cartilage. 3: 334-341 A1 Journal article (refereed), original research

Diffusion of Gd-DTPA2- into articular cartilage

Salo E-N, Nissi MJ, Kulmala KAM, Tiitu V, Töyräs J, Nieminen MT. 2012. Osteoarthritis and cartilage. 20: 117-126 A1 Journal article (refereed), original research

In vivo comparison of delayed gadolinium-enhanced MRI of cartilage and delayed quantitative CT arthrography in imaging of articular cartilage

Hirvasniemi J, Kulmala KAM, Lammentausta E, Ojala R, Lehenkari P, Kamel A, Jurvelin JS, Töyräs J, Nieminen MT and Saarakkala S. 2012. Osteoarthritis and cartilage. xx: xx A1 Journal article (refereed), original research

Multi-site bone ultrasound measurements in elderly women with and without previous hip fractures

Karjalainen JP., Riekkinen O., Töyräs J., Hakulinen M., Kröger H., Rikkonen T., Salovaara K., Jurvelin JS.. 2012. Osteoporosis international. 23: 1287-1295 A1 Journal article (refereed), original research

Nondestructive fluorescence-based quantification of threose-induced collagen cross-linking in bovine articular cartilage

Kinnunen Jussi, Kokkonen Harri T, Kovanen Vuokko, Hauta-Kasari Markku, Vahimaa Pasi, Lammi Mikko J, Töyräs Juha, Jurvelin Jukka S. 2012. Journal of biomedical optics. 17: 97003 A1 Journal article (refereed), original research

Repair of osteochondral defects with recombinant human type II collagen gel and autologous chondrocytes in rabbit

Pulkkinen HJ, Tiitu V, Valonen P, Jurvelin JS, Rieppo L, Töyräs J, Silvast TS, Lammi MJ, Kiviranta I. 2012. Osteoarthritis and cartilage. : -- A1 Journal article (refereed), original research

Simultaneous quantitative ultrasound assessment of cartilage and subchondral bone

Liukkonen J, Hirvasniemi J, Joukainen A, Penttilä P, Virén T, Jurvelin, JS, Töyräs, J. 2012.

Total duration of apnea and hypopnea events and average desaturation show significant variation in patients with a similar apnea-hypopnea index

Muraja-Murro A, Nurkkala J, Tiihonen P, Hukkanen T, Tuomilehto H, Kokkarinen J, Mervaala E, Töyräs J. 2012. Journal of medical engineering and technology. 36: 393-398 A1 Journal article (refereed), original research

Ultrasonic evaluation of acute impact injury of articular cartilage in vitro

Virén T, Timonen M, Tyrväinen H, Tiitu V, Jurvelin JS, Töyräs J. 2012. Osteoarthritis and cartilage. 20: 719-726 A1 Journal article (refereed), original research

Alterations in structure and properties of collagen network of osteoarthritic and repaired cartilage modify knee joint stresses

Mononen ME, Julkunen P, Toyras J, Jurvelin JS, Kiviranta I, Korhonen RK. 2011. Biomechanics and modeling in mechanobiology. 10: 357-369 A1 Journal article (refereed), original research

Arthroscopic Ultrasound Assessment of Articular Cartilage in the Human Knee Joint

Kaleva Erna, Viren Tuomas, Saarakkala Simo, Sahlman Janne, Sirola Joonas, Puhakka Jani, Paatela Teemu, Kröger Heikki, Kiviranta Ilkka, Jurvelin Jukka, Töyräs Juha. 2011. Cartilage. 2: 246-253 A1 Journal article (refereed), original research

Collagen cross-link modified fluorescence excitation-emission matrix of articular cartilage

Kinnunen Jussi, Hauta-Kasari Markku, Kokkonen Harri, Vahimaa Pasi, Lammi Mikko, Töyräs Juha, Jurvelin Jukka. Teoksessa: N/A(toim.) , 2011. Topical problems of biophotonics -2011, proceedings. s. 59-60. D3 Professional conference proceedings

Computed tomography detects changes in contrast agent diffusion after collagen cross-linking typical to natural aging of articular cartilage

Kokkonen HT, Mäkelä J, Kulmala KAM, Rieppo L, Jurvelin JS, Tiitu V, Karjalainen HM, Korhonen RK, Kovanen V, Töyräs J. 2011. Osteoarthritis and cartilage. 19: 1190-1198 A1 Journal article (refereed), original research

Contrast enhanced computed tomography in evaluation of spontaneous cartilage repair

Kulmala K.A.M, Pulkkinen H.J, Rieppo L, Tiitu V, Kiviranta I, Brünott A, Brommer H, van Weeren R, Brama P.A.J, Mikkola M.T, Korhonen R.K, Jurvelin J.S, Töyräs J.. 2011.

Detection of mechanical injury of articular cartilage using contrast enhanced computed tomography

Kokkonen HT, Jurvelin JS, Tiitu V, Töyräs J. 2011. Osteoarthritis and cartilage. 19: 297-301 A1 Journal article (refereed), original research

Effects of non-optimal focusing on dual-frequency ultrasound measurements of bone

Malo MK, Karjalainen JP, Riekkinen O, Isaksson H, Jurvelin JS, Töyräs J.. 2011. IEEE transactions on ultrasonics ferroelectrics and frequency control. 58: 1182-1188 B1 Non-refereed journal articles

Effects of optical beam angle on quantitative optical coherence tomography (OCT) in normal and surface degenerated bovine articular cartilage.

Huang YP, Saarakkala S, Töyräs J, Wang LK, Jurvelin JS, Zheng YP.. 2011. Physics in medicine and biology. 56: 491-509 A1 Journal article (refereed), original research

Evaluation of Joint Cartilage and Subchondral Bone using Arthroscopic Ultrasound Imaging

Penttilä P, Liukkonen J, Joukainen A, Virén T, Jurvelin JS, Kröger H, Töyräs J. 2011. Suomen Ortopedia ja Traumatologia. 34: 229 D1 Article in a trade journal

Hyperosmolaric Contrast Agents in Cartilage Tomography May Expose Cartilage to Overload- Induced Cell Death

Turunen MJ, Töyräs J, Lammi MJ, Jurvelin JS, Korhonen RK. 2011. Journal of biomechanics. 45: 497-503 A1 Journal article (refereed), original research

Kartiokeila-TT kokeellisen rustovaurion diagnostiikassa

Salo J, Kokkonen HT, Kröger H, Jurvelin JS, Töyräs J. 2011. Suomen Ortopedia ja Traumatologia. 34: 288-289 D1 Article in a trade journal

Simultaneous quantitative ultrasound assessment of cartilage and subchondral bone

Liukkonen J, Aula A, Töyräs J, Jurvelin JS. 2011.

Structural parameters of normal and osteoporotic human trabecular bone are affected differently by microCT image resolution

Isaksson, Hanna; Töyräs, J; Hakulinen, M; Aula, AS; Tamminen, Inari; Julkunen, P; Kröger, Heikki; Jurvelin, Jukka. 2011. Osteoporosis international. 22: 167-177 A1 Journal article (refereed), original research

Technical and practical improvements in arthroscopic indentation technique for diagnostics of articular cartilage softening

Timonen MA, Töyräs J, Aula AS, Karjalainen JP, Riekkinen O, Jurvelin JS. 2011. Journal of medical engineering and technology. 35: 40-46 A1 Journal article (refereed), original research

Ultrasound evaluation of mechanical injury of bovine knee articular cartilage under arthroscopic control

Virén Tuomas, Saarakkala Simo, Tiitu Virpi, Puhakka Jani, Kiviranta Ilkka, Jurvelin Jukka S, Töyräs Juha. 2011. IEEE transactions on ultrasonics ferroelectrics and frequency control. 58: 148-154 A1 Journal article (refereed), original research

2-D Finite Difference Time Domain Model of Ultrasound Reflection From Normal and Osteoarthritic Human Articular Cartilage Surface

Kaleva E., Liukkonen J, Töyräs J, Saarakkala S, Kiviranta P, and Jurvelin JS. 2010. IEEE transactions on ultrasonics ferroelectrics and frequency control. 57: 892-9 A1 Journal article (refereed), original research

Bone Quantitative Ultrasound

Laugier P. and Haiat G.. 2010. . 1st Edition. Springer C1 Book

Diffusion coefficients of articular cartilage for different CT and MRI contrast agents

Kulmala K.A.M.,Korhonen R.K.,Julkunen P,Jurvelin J.S.,Quinn T.M.,Kröger H,Töyräs J. 2010. Medical engineering and physics. 32: 878-882 A1 Journal article (refereed), original research

Diffusion of CT and MRI contrast agents in articular cartilage in vitro

Kulmala KAM, Korhonen RK, Julkunen P, Jurvelin JS, Quinn TM, Kröger H, Töyräs J. 2010.

Diffusivity and kinetics of gadopentetate in articular cartilage in vitro

Salo, E-N., Nissi, M. J., Kulmala K. A., Töyräs J., Nieminen M. T.. 2010.

Dynamics of contrast agent enhancement of intact and enzymatically degraded articular cartilage

Salo, E-N., Nissi, M. J., Kulmala K. A., Töyräs J., Nieminen M. T.. 2010.

Effect of Degenerative Changes of Articular Cartilage on Knee Joint Stresses ¿ Functional Imaging by Combining Clinical MRI and Finite Element Modeling

Mononen, M E; Julkunen, P; Jurvelin, J S; Töyräs, J; Korhonen, R K. Teoksessa: Smith & Nephew, Inc.(toim.) , 2010. Transactions of the Orthopaedic Research Society. s. 865. A4 Conference proceedings

Simultaneous ultrasound measurement of articular cartilage and subchondral bone

Aula AS, Töyräs J, Tiitu V, Jurvelin JS. 2010. Osteoarthritis and cartilage. 18: 1570-1576 A1 Journal article (refereed), original research

Temporal dynamics and diffusion of gadopentetate in articular cartilage at MRI concentrations in vitro

Salo E-N., Nissi M. J., Kulmala K., Töyräs J., Nieminen M. T.. 2010.

Accuracy of automatic analysis of ambulatory recordings of nocturnal breathing disorders is significantly instrumentation dependent

Tiihonen P, Hukkanen T, Tuomilehto H, Mervaala E, Pääkkönen A, Töyräs J. 2009. Journal of medical engineering and technology. 33: 386-393 A1 Journal article (refereed), original research

Contrast agent-enhanced computed tomography of articular cartilage: association with tissue composition and properties

Silvast TS, Jurvelin JS, Aula AS, Lammi MJ, Töyräs J. 2009. Acta radiologica. 50: 78-85 A1 Journal article (refereed), original research

Design, construction and evaluation of an ambulatory device for screening of sleep apnea

Tiihonen P, Pääkkönen A, Mervaala E, Hukkanen T, Töyräs J. 2009. Medical and biological engineering and computing. 47: 59-66 A1 Journal article (refereed), original research

Differences in acoustic properties of intact and degenerated human patellar cartilage during compression

Kiviranta P, Lammentausta E, Töyräs J, Nieminen HJ, Julkunen P, Kiviranta I, Jurvelin JS. 2009. Ultrasound in medicine and biology. 35: 1367-1375 A1 Journal article (refereed), original research

Diffusion and near-equilibrium distribution of MRI and CT contrast agents in articular cartilage

Silvast TS, Kokkonen HT, Jurvelin JS, Quinn TM, Nieminen MT, Töyräs J. 2009. Physics in medicine and biology. 54: 6823-6836 A1 Journal article (refereed), original research

Effect of bone marrow on acoustic properties of trabecular bone - 3D finite difference modelling study

Aula AS, Töyräs J, Hakulinen MA, Jurvelin JS. 2009. Ultrasound in medicine and biology. 35: 308-318 A1 Journal article (refereed), original research

Effects of ultrasound beam angle and surface roughness on the quantitative ultrasound parameters of articular cartilage

Kaleva E, Saarakkala S, Jurvelin JS, Viren T, Töyräs J. 2009. Ultrasound in medicine and biology. 35: 1344-1351 A1 Journal article (refereed), original research

Effects of ultrasound frequency, temporal sampling frequency, and spatial sampling step on the quantitative ultrasound parameters of articular cartilage

Kaleva E, Töyräs J, Jurvelin JS, Viren T, Saarakkala S. 2009. IEEE transactions on ultrasonics ferroelectrics and frequency control. 56: 1383-1393 A1 Journal article (refereed), original research

Evaluation of a novel ambulatory device for screening of sleep apnea

Tiihonen P, Hukkanen T, Tuomilehto H, Mervaala E, Töyräs J. 2009. Telemedicine and e-health. 15: 283-289 A1 Journal article (refereed), original research

Fabrication and testing of polyimide-based microelectrode arrays for cortical mapping of evoked potentials

Myllymaa S, Myllymaa K, Korhonen H, Töyräs J, Jääskeläinen JE, Djupsund K, Tanila H, Lappalainen R. 2009. Biosensors and bioelectronics. 24: 3067-3072 A1 Journal article (refereed), original research

Minimally invasive ultrasound method for intra-articular diagnostics of cartilage degeneration

Viren T, Saarakkala S, Kaleva E, Nieminen HJ, Jurvelin JS, Töyräs J. 2009. Ultrasound in medicine and biology. 35: 1546-1554 A1 Journal article (refereed), original research

Simultaneous computed tomography of articular cartilage and subchondral bone

Aula AS, Jurvelin JS, Töyräs J. 2009. Osteoarthritis and cartilage. 17: 1583-1588 A1 Journal article (refereed), original research

Strain-dependent modulation of ultrasound speed in articular cartilage under dynamic compression

Lötjönen P, Julkunen P, Töyräs J, Lammi MJ, Jurvelin JS, Nieminen HJ. 2009. Ultrasound in medicine and biology. 35: 1177-1184 A1 Journal article (refereed), original research

Ultrasound backscatter imaging provides frequency-dependent information on structure, composition and mechanical properties of human trabecular bone

Karjalainen JP, Töyräs J, Riekkinen O, Hakulinen M, Jurvelin JS. 2009. Ultrasound in medicine and biology. 35: 1376-1384 A1 Journal article (refereed), original research

Ultrasound backscattering outperforms the clinically used ultrasound parameters in discrimination of osteoporotic-like human trabecular bone samples

Karjalainen J, Töyräs J, Riekkinen O, Hakulinen MA. Teoksessa: Dössel O, Schlegel WC(toim.) , 2009. World Congress on Medical Physics and Biomedical Engineering. Diagnostic Imaging. IFMBE Proceedings. s. 94-97. Springer A4 Conference proceedings

pQCT study on diffusion and equilibrium distribution of iodinated anionic contrast agent in human articular cartilage - associations to matrix composition and integrity

Silvast TS, Jurvelin JS, Lammi MJ, Töyräs J. 2009. Osteoarthritis and cartilage. 17: 26-32 A1 Journal article (refereed), original research

A portable device for intensive care brain function monitoring with event-related potentials

Tiihonen P, Kinnunen J, Töyräs J, Mervaala E, Pääkkönen A. 2008. Computer methods and programs in biomedicine. 89: 83-92 A1 Journal article (refereed), original research

Dual frequency ultrasound technique minimizes errors induced by soft tissues in ultrasound bone densitometry

Janne Karjalainen, Juha Töyräs, Toni Rikkonen, Jukka Jurvelin, Ossi Riekkinen. 2008. Acta radiologica. 49: 1038-41 A1 Journal article (refereed), original research

Dual-frequency ultrasound - new pulse-echo technique for bone densitometry

Riekkinen O, Hakulinen MA, Töyräs J, Jurvelin JS. 2008. Ultrasound in medicine and biology. 34: 1703-1708 A1 Journal article (refereed), original research

Dual-frequency ultrasound technique minimizes errors induced by soft tissue in ultrasound bone densitometry

Karjalainen J, Töyräs J, Rikkonen T, Jurvelin JS, Riekkinen O. 2008. Acta radiologica. 49: 1038-1041 A1 Journal article (refereed), original research

Fysikaaliset ja kemialliset menetelmät nivelrikon varhaisessa osoittamisessa

Jurvelin JS, Nieminen MT, Töyräs J, Risteli J, Laasanen MS, Konttinen YT, Kiviranta I. 2008. Duodecim. 124: 1885-1896 A1 Journal article (refereed), original research

In-vitro comparison of time-domain, frequency-domain and wavelet ultrasound parameters in diagnostics of cartilage degeneration

Kaleva E, Saarakkala S, Töyräs J, Nieminen HJ, Jurvelin JS. 2008. Ultrasound in medicine and biology. 34: 155-159 A1 Journal article (refereed), original research

The zonal architecture of human articular cartilage described by T2 relaxation time in the presence of Gd-DTPA2-

Kurkijärvi JE, Nissi MJ, Rieppo J, Töyräs J, Kiviranta I, Nieminen MT, Jurvelin JS. 2008. Magnetic resonance imaging. 26: 602-607 A1 Journal article (refereed), original research

Ultrasonic assessment of cortical bone thickness In Vitro and In Vivo

Karjalainen J, Riekkinen O, Töyräs J, Kröger H, Jurvelin J. 2008. IEEE transactions on ultrasonics ferroelectrics and frequency control. 55: 2191-2197 A1 Journal article (refereed), original research

Acoustic properties of trabecular bone-relationships to tissue composition

Riekkinen O, Hakulinen MA, Lammi MJ, Jurvelin JS, Kallioniemi A, Töyräs J. 2007. Ultrasound in medicine and biology. 33: 1438-1444 A1 Journal article (refereed), original research

Comparison of novel clinically applicable methodology for sensitive diagnostics of cartilage degeneration

Kiviranta P, Töyräs J, Nieminen MT, Laasanen MS, Saarakkala S, Nieminen HJ, Nissi MJ, Jurvelin J. 2007. European cells and materials. 13: 46-55 A1 Journal article (refereed), original research

Contrast agent enhanced pQCT of articular cartilage

Kallioniemi AS, Jurvelin JS, Nieminen MT, Lammi MJ, Töyräs J. 2007. Physics in medicine and biology. 52: 1209-1219 A1 Journal article (refereed), original research

Effect of human trabecular bone composition on its electrical properties

Sierpowska J, Lammi MJ, Hakulinen MA, Jurvelin JS, Lappalainen R, Töyräs J. 2007. Medical engineering and physics. 29: 845-852 A1 Journal article (refereed), original research

Estimation of mechanical properties of articular cartilage with MRI - dGEMRIC, T2 and T1 imaging in different species with variable stages of maturation

Nissi MJ, Rieppo J, Töyräs J, Laasanen MS, Kiviranta I, Nieminen MT, Jurvelin JS. 2007. Osteoarthritis and cartilage. 15: 1141-1148 A1 Journal article (refereed), original research

Human articular cartilage proteoglycans are not undesulfated in osteoarthritis

Qu CJ, Rieppo J, Hyttinen MM, Lammi MJ, Kiviranta I, Kurkijärvi J, Jurvelin J, Töyräs J. 2007. Connective tissue research. 48: 27-33 A1 Journal article (refereed), original research

Quantitative MRI of parallel changes of articular cartilage and underlying trabecular bone in degeneration

Lammentausta E, Kiviranta P, Töyräs, Hyttinen MM, Kiviranta I, Nieminen MT, Jurvelin JS. 2007. Osteoarthritis and cartilage. 15: 1149-1157 A1 Journal article (refereed), original research

Quantitative information from ultrasound evaluation of articular cartilage should be interpreted with care

Saarakkala S, Jurvelin JS, Zheng YP, Nieminen HJ, Töyräs J. 2007. Arthroscopy-the journal of arthroscopic and related surgery

Spatial variation of acoustic properties is related with mechanical properties of trabecular bone

Riekkinen O, Hakulinen MA, Töyräs J, Jurvelin JS. 2007. Physics in medicine and biology. 52: 6961-6968 A1 Journal article (refereed), original research

Ultrasound speed in articular cartilage under mechanical compression

Nieminen HJ, Julkunen P, Töyräs J, Jurvelin JS. 2007. Ultrasound in medicine and biology. 33: 1755-1766 A1 Journal article (refereed), original research

Acoustic properties articular cartilage under mechanical stress

Nieminen HJ, Töyräs J, Laasanen MS, Jurvelin JS. 2006. Biorheology. 43: 523-535 A1 Journal article (refereed), original research

Collagen network primarily controls Poisson's ratio of bovine articular cartilage in compression

Kiviranta P, Rieppo J, Korhonen RK, Julkunen P, Töyräs J, Jurvelin JS. 2006. Journal of orthopaedic research. 24: 690-699 A1 Journal article (refereed), original research

Influence of overlying soft tissues on trabecular bone acoustic measurement at various ultrasound frequencies

Riekkinen O, Hakulinen MA, Timonen M, Töyräs J, Jurvelin JS. 2006. Ultrasound in medicine and biology. 32: 1073-1083 A1 Journal article (refereed), original research

Interrelationships between electrical proberties and microstructure of human trabecular bone

Sierpowska J, Hakulinen MA, Töyräs J, Day JS, Weinans H, Kiviranta I, Jurvelin JS, Lappalainen R. 2006. Physics in medicine and biology. 51: 5289-5303 A1 Journal article (refereed), original research

Quantitative ultrasound imaging detects degenerative changes in articulas cartilage surface and subchondral bone

Saarakkala S, Laasanen MS, Jurvelin JS, Töyräs J. 2006. Physics in medicine and biology. 51: 5333-5346 A1 Journal article (refereed), original research

Quantitative ultrasound imaging of spontaneous repair of porcine cartilage

Laasanen MS, Töyräs J, Vasara A, Saarakkala S, Hyttinen MM, Kiviranta I, Jurvelin JS. 2006. Osteoarthritis and cartilage. 14: 258-263 A1 Journal article (refereed), original research

T2 relaxation time mapping reveals age- and species-related diversity of collagen network architecture in articular cartilage

Nissi MJ, Rieppo J, Töyräs J, Laasanen MS, Kiviranta I, Jurvelin JS, Nieminen MT. 2006. Osteoarthritis and cartilage. 14: 1265-1271 A1 Journal article (refereed), original research

Ultrasonic characterization of human trabecular bone microstructure

Hakulinen MA, Day JS, Töyräs J, Weinans H, Jurvelin JS, Hakulinen MA. 2006. Physics in medicine and biology. 51: 1633-1648 A1 Journal article (refereed), original research

Ultrasound stimulates proteoglycan synthesis in bovine primary chondrocytes

Kopakkala-Tani M, Leskinen JJ, Karjalainen HM, Karjalainen T, Hynynen K, Töyräs J, Jurvelin JS, Lammi MJ. 2006. Biorheology. 43: 271-282 A1 Journal article (refereed), original research

Improvement of arthroscopic cartilage stiffness probe using amorphous diamond coating

Töyräs J, Korhonen RK, Voutilainen T, Jurvelin JS, Lappalainen R. 2005. Journal of biomedical materials research part b: applied biomaterials. 73B: 15-22 A1 Journal article (refereed), original research

Prediction of density and mechanical properties of human trabecular bone in vitro by using ultrasound transmission and backscattering measurements at 0.2-6.7 MHz frequency range

Hakulinen MA, Day JS, Töyräs J, Timonen M, Kröger H, Weinans H, Kiviranta I, Jurvelin JS, Kröger H. 2005. Physics in medicine and biology. 50: 1629-1642 A1 Journal article (refereed), original research

Prediction of mechanical properties of human trabecular bone by electrical measurements

Sierpowska J, Hakulinen MA, Töyräs J, Day JS, Weinans H, Jurvelin JS, Lappalainen R. 2005. Physiological measurement. 26: S119-S131 A1 Journal article (refereed), original research

Site-specific ultrasound reflection properties and superficial collagen content of bovine knee articular cartilage

Laasanen MS, Saarakkala S, Töyräs J, Rieppo J, Jurvelin JS. 2005. Physics in medicine and biology. 50: 3221-3233 A1 Journal article (refereed), original research

Ability of ultrasound backscattering to predict mechanical properties of bovine trabecular bone

Hakulinen MA, Töyräs J, Saarakkala S, Hirvonen J, Kröger H, Jurvelin JS, Kröger H. 2004. Ultrasound in medicine and biology. 30: 919-927 A1 Journal article (refereed), original research

Mechano-acoustic determination of Young's moduls of articular cartilage

Saarakkala S, Korhonen RK, Laasanen MS, Töyräs J, Rieppo J, Jurvelin JS. 2004. Biorheology. 41: 167-179 A1 Journal article (refereed), original research

Prediction of biomechanical properties of articular cartilage with quantitative magnetic resonance imaging

Nieminen MT, Töyräs J, Laasanen MS, Silvennoinen J, Helminen HJ, Jurvelin JS. 2004. Journal of biomechanics. 37: 321-328 A1 Journal article (refereed), original research

Proteoglycan and collagen sensitive MRI evaluation of normal and degenerated articular cartilage

Nissi MJ, Töyräs J, Laasanen MS, Rieppo J, Saarakkala S, Lappalainen R, Jurvelin JS, Nieminen MT. 2004. Journal of orthopaedic research. 22: 557-564 A1 Journal article (refereed), original research

Ultrasonic quantitation of superficial degradation of articular cartilage

Saarakkala S, Töyräs J, Hirvonen J, Laasanen MS, Lappalainen R, Jurvelin JS. 2004. Ultrasound in medicine and biology. 30: 783-792 A1 Journal article (refereed), original research

Ultrasound attenuation in normal and spontaneously degenerated articular cartilage

Nieminen HJ, Saarakkala S, Laasanen MS, Hirvonen J, Jurvelin JS, Töyräs J. 2004. Ultrasound in medicine and biology. 30: 493-500 A1 Journal article (refereed), original research

Undersulfated chondroitin sulfate does not increase in osteoarthritic cartilage

Lammi MJ, Qu C-J, Laasanen MS, Saarakkala S, Rieppo J, Jurvelin JS, Töyräs J. 2004. Journal of rheumatology. 31: 2449-2453 A1 Journal article (refereed), original research

Biomechanical properties of knee articular cartilage

Laasanen MS, Töyräs J, Korhonen RK, Rieppo J, Saarakkala S, Nieminen MT, Hirvonen J, Jurvelin JS. 2003. Biorheology. 40: 133-140 A1 Journal article (refereed), original research

Dual energy x-ray laser measurement of calcaneal bone mineral density

Hakulinen MA, Saarakkala S, Töyräs J, Kröger H, Jurvelin JS. 2003. Physics in medicine and biology. 48: 1741-1752 A1 Journal article (refereed), original research

Electrical and dielectric properties of bovine trabecular bone - relationship with mechanical properties and mineral density

Sierpowska J, Töyräs J, Hakulinen MA, Saarakkala S, Jurvelin JS, Lappalainen R. 2003. Physics in medicine and biology. 48: 775-786 A1 Journal article (refereed), original research

Experimental and numerical validation for the novel configuration of an arthroscopic indentation instrument

Korhonen RK, Saarakkala S, Töyräs J, Laasanen MS, Kiviranta I, Jurvelin JS. 2003. Physics in medicine and biology. 48: 1565-1576 A1 Journal article (refereed), original research

Fibril reinforced poroelastic model predicts specifically mechanical behavior of normal, proteoglycan depleted and collagen degraded articular cartilage

Korhonen RK, Laasanen MS, Töyräs J, Lappalainen R, Helminen HJ, Jurvelin JS. 2003. Journal of biomechanics. 36: 1373-1379 A1 Journal article (refereed), original research

Mechano-acoustic diagnosis of cartilage degeneration and repair

Laasanen MS, Töyräs J, Vasara AI, Hyttinen MM, Saarakkala S, Hirvonen J, Jurvelin JS, Kiviranta I. 2003. JOURNAL OF BONE AND JOINT SURGERY (AM) SUPPLEMENT. 85-A: 78-84 A1 Journal article (refereed), original research

Speed of sound in normal and degenerated bovine articular cartilage

Töyräs J, Laasanen MS, Saarakkala S, Lammi MJ, Rieppo J, Kurkijärvi J, Lappalainen R, Jurvelin JS. 2003. Ultrasound in medicine and biology. 29: 447-454 A1 Journal article (refereed), original research

Structure-function relationships in enzymatically modified articular cartilage

Rieppo J, Töyräs J, Nieminen MT, Kovanen V, Hyttinen MM, Korhonen RK, Jurvelin JS, Helminen HJ. 2003. Cells tissues organs. 175: 121-132 A1 Journal article (refereed), original research

Ultrasound indentation of bovine knee articular cartilage in situ

Laasanen MS, Saarakkala S, Töyräs J, Hirvonen J, Rieppo J, Korhonen RK, Jurvelin JS. 2003. Journal of biomechanics. 36: 1259-1267 A1 Journal article (refereed), original research

Ultrasound indentation of normal and spontaneously degenerated bovine articular cartilage

Saarakkala S, Laasanen MS, Jurvelin JS, Törrönen K, Lammi MJ, Lappalainen R, Töyräs J. 2003. Osteoarthritis and cartilage. 11: 697-705 A1 Journal article (refereed), original research

Bone mineral density, ultrasound velocity, and broadband attenuation predict mechanical properties of trabecular bone differently

Töyräs J, Nieminen MT, Kröger H, Jurvelin JS. 2002. Bone. 31: 503-507 A1 Journal article (refereed), original research

Comparison of the equilibrium response of articular cartilage in unconfined compression, confined compression and indentation

Korhonen RK, Laasanen MS, Töyräs J, Rieppo J, Hirvonen J, Helminen HJ, Jurvelin JS. 2002. Journal of biomechanics. 35: 903-909 A1 Journal article (refereed), original research

Novel mechano-acoustic technigue and instrument for diagnosis of cartilage degeneration

Laasanen MS, Töyräs J, Hirvonen J, Saarakkala S, Korhonen RK, Nieminen MT, Kiviranta I, Jurvelin JS. 2002. Physiological measurement. 23: 491-503 A1 Journal article (refereed), original research

Real-time ultrasound analysis of articular cartilage degradation in vitro

Nieminen HJ, Töyräs J, Rieppo J, Nieminen MT, Hirvonen J, Korhonen R, Jurvelin JS. 2002. Ultrasound in medicine and biology. 28: 519-525 A1 Journal article (refereed), original research

Spatial assessment of articular cartilage proteoglycans with Gd-DTPA-enhanced T1 imaging

Nieminen MT, Rieppo J, Silvennoinen J, Töyräs J, Hakumäki JM, Hyttinen MM, Helminen HJ, Jurvelin JS. 2002. Magnetic resonance in medicine. 48: 640-648 A1 Journal article (refereed), original research

Ultrasonic characterization of articular cartilage

Töyräs J, Nieminen HJ, Laasanen MS, Nieminen MT, Korhonen RK, Rieppo J, Hirvonen J, Helminen HJ, Jurvelin JS. 2002. Biorheology. 39: 161-169 A1 Journal article (refereed), original research

Development of arthroscopic indentation technique for the diagnosis of cartilage degeneration

Lyyra-Laitinen T, Töyräs J, Kiviranta I, Jurvelin JS. Teoksessa: Kotila S, Haataja J(toim.) , 2001. CSC Report on Scientific Computing 1999-2000. s. 181-184. CSC - Scientific Computing A3 Book section, Chapters in research books

Estimation of the Young's modulus of articular cartilage using an arthroscopic indentation instrument and ultrasonic measurement of tissue thickness

Töyräs J, Lyyra-Laitinen T, Niinimäki M, Lindgren R, Nieminen MT, Kiviranta I, Jurvelin JS. 2001. Journal of biomechanics. 34: 251-256 A1 Journal article (refereed), original research

Inactivation of one allele of the type II collagen gene alters the collagen network in murine articular cartilage and makes cartilage softer

Hyttinen MM, Töyräs J, Lapveteläinen T, Lindblom J, Prockop DJ, Li S-W, Arita M, Jurvelin JS, Helminen HJ. 2001. Annals of the rheumatic diseases. 60: 262-268 A1 Journal article (refereed), original research

Mechano-Acoustic Characterization of Articular Cartilage and Trabecular Bone

Töyräs J. 2001. Kuopion yliopiston julkaisuja C. Luonnontieteet ja ympäristötieteet G5 Doctoral dissertation (article)

T2 Relaxation reveals spatial collagen architecture in articular cartilage: a comparative quantitative MRI and polarized light microscopic study

Nieminen MT, Rieppo J, Töyräs J, Hakumäki JM, Silvennoinen J, Hyttinen MM, Helminen HJ, Jurvelin JS. 2001. Magnetic resonance in medicine. 46: 487-493 D1 Article in a trade journal

Quantitative MR microscopy of enzymatically degraded articular cartilage

Nieminen MT, Töyräs J, Rieppo J, Hakumäki JM, Silvennoinen J, Helminen HJ, Jurvelin JS. 2000. Magnetic resonance in medicine. 43: 676-681 A1 Journal article (refereed), original research

Bone properties as estimated by mineral density, ultrasound attenuation, and velocity

Töyräs J, Kröger H, Jurvelin JS. 1999. Bone. 25: 725-731 A1 Journal article (refereed), original research

Characterization of enzymatically induced degradation of articular cartilage using high frequency ultrasound

Töyräs J, Rieppo J, Nieminen MT, Helminen HJ, Jurvelin JS. 1999. Physics in medicine and biology. 44: 2723-2733 A1 Journal article (refereed), original research

Optimization of the arthroscopic indentation instrument for the measurement of thin cartilage stiffness

Lyyra-Laitinen T, Niinimäki M, Töyräs J, Lindgren R, Kiviranta I, Jurvelin JS. 1999. Physics in medicine and biology. 44: 2511-2524 A1 Journal article (refereed), original research

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Arousal burden is highest in supine sleeping position and during light sleep

Beat-to-beat cardiac repolarization lability increases during hypoxemia and arousals in obstructive sleep apnea patients

Estimation of Photon Path Length and Penetration Depth in Articular Cartilage Zonal Architecture over the Therapeutic Window

Increased Flow Limitation During Sleep Is Associated With Increased Psychomotor Vigilance Task Lapses in Individuals With Suspected OSA

Increased flow limitation during sleep is associated with decreased psychomotor vigilance task performance in individuals with suspected obstructive sleep apnea: a multi-cohort study

Infrared Spectroscopy Can Differentiate Between Cartilage Injury Models: Implication for Assessment of Cartilage Integrity

Laser-irradiating infrared attenuated total reflection spectroscopy of articular cartilage: Potential and challenges for diagnosing osteoarthritis

Prolonged lung-to-finger circulation time indicates an increased risk of intermittent hypoxaemia in sleep apnoea patients

Relationship between depth-wise refractive index and biomechanical properties of human articular cartilage

Respiratory event index underestimates severity of sleep apnea compared to apnea-hypopnea index

Retrospective validation of automatic sleep analysis with grey areas model for human‐in‐the‐loop scoring approach

Site-specific elastic and viscoelastic biomechanical properties of healthy and osteoarthritic human knee joint articular cartilage

Sleep stage continuity is associated with objective daytime sleepiness in patients with suspected obstructive sleep apnea

Temporal and sleep stage‐dependent agreement in manual scoring of respiratory events

Variation in the Photoplethysmogram Response to Arousal From Sleep Depending on the Cause of Arousal and the Presence of Desaturation

“An excellent servant but a terrible master”: Understanding the value of wearables for self-management in people with cystic fibrosis and their healthcare providers – A qualitative study

3-D T1 relaxation time measurements in an equine model of subtle post-traumatic osteoarthritis using MB-SWIFT

Acute cardiorespiratory coupling impairment in worsening sleep apnea-related intermittent hypoxemia

Articular Cartilage Characterization Using Tantalum and Iodine-based Dual-Contrast Photon-Counting Computed Tomography

Automated Tool for Musculoskeletal Finite Element Modeling of Knee

Broadband scattering properties of articular cartilage zones and their relationship with the heterogenous structure of articular cartilage extracellular matrix

Cationic tantalum oxide nanoparticle contrast agent for micro computed tomography reveals articular cartilage proteoglycan distribution and collagen architecture alterations

Characterisation of Cartilage Damage via Fusing Mid-Infrared, Near-Infrared, and Raman Spectroscopic Data

Deep learning-based algorithm accurately classifies sleep stages in preadolescent children with sleep-disordered breathing symptoms and age-matched controls

Effect Of Depth-dependent Variation In Articular Cartilage Composition On Nanoparticle Diffusion

Generalizable Deep Learning-based Sleep Staging Approach for Ambulatory Textile Electrode Headband Recordings

Impact of experimental setup parameters on the measurement of articular cartilage optical properties in the visible and short near-infrared spectral bands

Nasal Pressure Derived Airflow Limitation and Ventilation Measurements are Resilient to Reduced Signal Quality

Near-infrared spectroscopic assessment of patellar tendon mechanics

Obstructive Sleep Apnea Patients With Atrial Arrhythmias Suffer From Prolonged Recovery From Desaturations

Oxygen resaturation rate is significantly associated with objectively assessed excessive daytime sleepiness in suspected obstructive sleep apnoea patients

Patellar tendon and tibial cartilage viscoelastic properties are inversely related in osteoarthritic knees

Power spectral analysis of the sleep electroencephalogram in positional obstructive sleep apnea

Raman Spectroscopy and Machine Learning Enables Estimation of Articular Cartilage Structural, Compositional, and Functional Properties

Reaction time in psychomotor vigilance task is related to hypoxic load in males with sleep apnea

Refractive index of human articular cartilage varies with tissue structure and composition

Review and perspective on sleep-disordered breathing research and translation to clinics

Self‐applied somnography: technical feasibility of electroencephalography and electro‐oculography signal characteristics in sleep staging of suspected sleep‐disordered adults

Tantalum And Iodine Based Dual-Contrast Photon-Counting Computed Tomography Method For Assessment Of Articular Cartilage Composition

Tantalum Oxide Nanoparticles For Contrast-Enhanced Computed Tomography Diagnosis Of Osteoarthritis

Towards a Deeper Understanding of Sleep Stages through their Representation in the Latent Space of Variational Autoencoders

Triple contrast computed tomography reveals site‐specific biomechanical differences in human knee joint – a proof of concept study

Visible and Near-Infrared Spectroscopy Enables Differentiation of Normal and Early Osteoarthritic Human Knee Joint Articular Cartilage

A Comparison of Signal Combinations for Deep Learning-Based Simultaneous Sleep Staging and Respiratory Event Detection

ABOSA – Freely available automatic blood oxygen saturation signal analysis software: Structure and validation

Assessment of Ligament Viscoelastic Properties Using Raman Spectroscopy

Deep Learning Enables Accurate Automatic Sleep Staging Based on Ambulatory Forehead EEG

Desaturation event scoring criteria affect the perceived severity of nocturnal hypoxic load

Dual‐contrast micro‐CT enables cartilage lesion detection and tissue condition evaluation ex vivo

Gamma Power of Electroencephalogram Arousal is Modulated by Respiratory Event Type and Severity in Obstructive Sleep Apnea

Infrared spectroscopy is suitable for objective assessment of articular cartilage health

Inter-sleep stage variations in corrected QT interval differ between obstructive sleep apnea patients with and without stroke history

Near infrared spectroscopic evaluation of biochemical and crimp properties of knee joint ligaments and patellar tendon

Near-Infrared Spectroscopy Enables Arthroscopic Histologic Grading of Human Knee Articular Cartilage

Novel oxygen desaturation parameters are associated with cardiac troponin I: Data from the Akershus Sleep Apnea Project

OSA-related respiratory events and desaturation severity are associated with the cardiac response

Obstructive sleep apnea‐related intermittent hypoxaemia is associated with impaired vigilance

Pulse Oximetry: The Working Principle, Signal Formation, and Applications

QTc prolongation is associated with severe desaturations in stroke patients with sleep apnea

STAR sleep recording export software for automatic export and anonymization of sleep studies

Self-Applied Electrode Set Provides a Clinically Feasible Solution Enabling EEG Recording in Home Sleep Apnea Testing

Site- and Zone-Dependent Changes in Proteoglycan Content and Biomechanical Properties of Bluntly and Sharply Grooved Equine Articular Cartilage

Tantalum Oxide Nanoparticles for Contrast Enhanced Computed Tomography Imaging of Cartilage

The Influence of Wearables on Health Care Outcomes in Chronic Disease: Systematic Review

The Sleep Revolution project: the concept and objectives

The severity and morphology of intermittent hypoxemias are related to impaired daytime alertness

An In-Laboratory Comparison of FocusBand EEG Device and Textile Electrodes Against a Medical-Grade System and Wet Gel Electrodes

Articular cartilage optical properties in the near-infrared (NIR) spectral range vary with depth and tissue integrity

Assessment of Obstructive Sleep Apnea-Related Sleep Fragmentation Utilizing Deep Learning-Based Sleep Staging from Photoplethysmography

Automatic Respiratory Event Scoring in Obstructive Sleep Apnea Using a Long Short-Term Memory Neural Network

Auttaako teknologia uniongelmiin?

Beyond the apnea-hypopnea index: alternative diagnostic parameters and machine learning solutions for estimation of sleep apnea severity

Biomechanical, biochemical, and near infrared spectral data of bovine knee ligaments and patellar tendon

Characterization of connective tissues using near-infrared spectroscopy and imaging

Detailed assessment of sleep architecture with deep learning and shorter epoch-to-epoch duration reveals sleep fragmentation of patients with obstructive sleep apnea

Diabetes and cardiovascular diseases are associated with the worsening of intermittent hypoxaemia

Dual-contrast computed tomography enables detection of equine posttraumatic osteoarthritis in vitro