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Jukka Pelkonen

Jukka Pelkonen

Professor, Emeritus

Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences

jukka.pelkonen@uef.fi

Information Publications

Research groups

North-Savo Skin Cancer Program (NoSCaP)

Publications

101/101 items

Loss of CD34+ Cells and Effect of the Number of Viable Cryopreserved CD34+ Cells in the Infused Blood Grafts on Hematologic Recovery, Progression-Free Survival and Overall Survival in NHL Patients After Autologous Stem Cell Transplantation
Partanen, Anu; Turunen, Antti; Valtola, Jaakko; Pyörälä, Marja; Kuittinen, Outi; Kuitunen, Hanne; Vasala, Kaija; Penttilä, Karri; Kuittinen, Taru; Mäntymaa, Pentti; Pelkonen, Jukka; Jantunen, Esa; Varmavuo, Ville. 2023. Clinical lymphoma myeloma and leukemia. 23: e428-e435
Impact of the number of cryopreserved CD34+ cells in the infused blood grafts on hematologic recovery and survival in myeloma patients after autologous stem cell transplantation: Experience from the GOA study
Partanen, Anu; Turunen, Antti; Silvennoinen, Raija; Valtola, Jaakko; Pyörälä, Marja; Siitonen, Timo; Sikiö, Anu; Putkonen, Mervi; Sankelo, Marja; Penttilä, Karri; Kuittinen, Taru; Mäntymaa, Pentti; Pelkonen, Jukka; Jantunen, Esa; Varmavuo, Ville. 2022. Journal of clinical apheresis. 2023; 38: 33-44
Autograft cellular composition and outcome in myeloma patients: Results of the prospective multicenter GOA study
Turunen, A; Silvennoinen, R; Partanen, A; Valtola, J; Siitonen, T; Putkonen, M; Sankelo, M; Pyörälä, M; Kuittinen, T; Penttilä, K; Sikiö, A; Savolainen, ER; Mäntymaa, P; Pelkonen, J; Varmavuo,V; Jantunen, E. 2021. Transfusion. 61: 1830-1844
Blood Graft and Outcome After Autologous Stem Cell Transplantation in Patients With Primary Central Nervous System Lymphoma
Partanen, Anu; Kuittinen, Outi; Turunen, Antti; Valtola, Jaakko; Pyörälä, Marja; Kuitunen, Hanne; Vasala, Kaija; Kuittinen, Taru; Mäntymaa, Pentti; Pelkonen, Jukka; Jantunen, Esa; Varmavuo, Ville. 2021. Journal of hematology. 10: 246-254
Comparison of CD34 + cell mobilization, blood graft cellular composition, and post-transplant outcome in myeloma patients mobilized with filgrastim or pegfilgrastim added to low-dose cyclophosphamide: A prospective multicenter study
Partanen, Anu; Turunen, Antti; Silvennoinen, Raija; Pyörälä, Marja; Valtola, Jaakko; Siitonen, Timo; Putkonen, Mervi; Sankelo, Marja; Sikiö, Anu; Penttilä, Karri; Kuittinen, Taru; Pelkonen, Jukka; Mäntymaa, Pentti; Jantunen, Esa; Varmavuo, Ville. 2021. Transfusion. 61: 3202-3212
A prospective comparison of pegfilgrastim and lipegfilgrastim combined with chemotherapy in the mobilization of CD34+ cells in NHL patients
Partanen, Anu; Turunen, Antti; Valtola, Jaakko; Vasala, Kaija; Ågren, Lasse; Penttilä, Karri; Pyörälä, Marja; Kuittinen, Taru; Mäntymaa, Pentti; Pelkonen, Jukka; Jantunen, Esa; Varmavuo, Ville. 2020. Journal of clinical apheresis. 35: 255-263
Autograft cellular composition and outcome in NHL patients: results of the prospective multicenter GOA study
Turunen, Antti; Valtola, Jaakko; Partanen, Anu; Ropponen, Antti; Kuittinen, Outi; Kuitunen, Hanne; Vasala, Kaija; Ågren, Lasse; Penttilä, Karri; Keskinen, Leena; Savolainen, Eeva-Riitta; Pyörälä, Marja; Kuittinen, Taru; Selander, Tuomas; Mäntymaa, Pentti; Pelkonen, Jukka; Jantunen, Esa; Varmavuo, Ville. 2020. Leukemia & lymphoma. 61: 2082-2092
Autologous stem cell transplantation in peripheral T-cell lymphoma: better mobilization of blood CD34 + cells is associated with improved survival
Partanen, A; Turunen, A; Valtola, J; Pyörälä, M; Vasala, K; Kuittinen, O; Kuitunen, H; Penttilä, K; Kuittinen, T; Mäntymaa, P; Pelkonen, J; Varmavuo, V Jantunen, E. 2020. Leukemia & lymphoma. 61: 3027-3029
Mobilization characteristics, blood graft composition, and outcome in diffuse large B-cell lymphoma after autologous stem cell transplantation: Results from the prospective multicenter GOA study
Partanen, Anu; Turunen, Antti; Valtola, Jaakko; Pyörälä, Marja; Vasala, Kaija; Kuittinen, Outi; Kuitunen, Hanne; Penttilä, Karri; Keskinen, Leena; Kuittinen, Taru; Mäntymaa, Pentti; Pelkonen, Jukka; Varmavuo, Ville; Jantunen, Esa. 2020. Transfusion. 2021; 61: 516-525
Pleriksafori kantasolujen mobilisaatiossa autologista siirtoa varten
Jantunen, Esa; Valtola, Jaakko; Partanen, Anu; Turunen, Antti; Kuittinen, Taru; Silvennoinen, Raija; Pyörälä, Marja; Mäntymaa, Pentti; Pelkonen, Jukka; Varmavuo, Ville. 2020. Duodecim. 136: 997-1004
Importance of early immune recovery after autologous hematopoietic cell transplantation in lymphoma patients
Jantunen, Esa; Varmavuo, Ville; Pelkonen, Jukka; Valtola, Jaakko. 2019. Leukemia & lymphoma. 60: 2115-2121
Mast Cells Are a Marked Source for Complement C3 Products That Associate with Increased CD11b-Positive Cells in Keratinocyte Skin Carcinomas
Rahkola, Dina; Laitala, Joel; Siiskonen, Hanna; Pelkonen, Jukka; Harvima, Ilkka T. 2019. Cancer investigation. 37: 73-84
Blood graft composition and post-transplant recovery in myeloma patients mobilized with plerixafor: a prospective multicenter study
Valtola, J; Silvennoinen, R; Ropponen, A; Siitonen, T; Säily, M; Sankelo, M; Putkonen, M; Partanen, A; Pyörälä, M; Savolainen, ER; Mäntymaa, P; Pelkonen, J; Jantunen, E; Varmavuo, V. 2018. Leukemia & lymphoma. 2019; 60: 453-461
Comparison of filgrastim, pegfilgrastim, and lipegfilgrastim added to chemotherapy for mobilization of CD34+ cells in non-Hodgkin lymphoma patients
Partanen, A; Valtola, J; Ropponen, A; Kuitunen, H; Kuittinen, O; Vasala, K; Ågren, L; Penttilä, K; Keskinen, L; Pyörälä, M; Nousiainen, T; Selander, T; Mäntymaa, P; Pelkonen, J; Varmavuo, V; Jantunen, E. 2018. Transfusion. 2019; 59: 325-334
The combination of TRAIL and MG-132 induces apoptosis in both TRAIL-sensitive and TRAIL-resistant human follicular lymphoma cells
Adem, Jemal; Eray, Mine; Eeva, Jonna; Nuutinen, Ulla; Pelkonen, Jukka. 2018. Leukemia research. 66: 57-65
Advantages of targeting B cell receptor complex to treat B-cell derived autoimmune diseases and lymphomas
Adem Jemal, Eray Mine, Eeva Jonna, Nuutinen Ulla, Pelkonen Jukka. 2017. Molecular immunology. 88: 135-137
CD40 Ligand Is Increased in Mast Cells in Psoriasis and Actinic Keratosis but Less So in Epithelial Skin Carcinomas
Haimakainen S, Kaukinen AP, Suttle M-M, Pelkonen J, Harvima IT. 2017. Cancer investigation. 35: 143-151
Immunoreactivity to CYP24A1, but not vitamin D receptor, is increased in mast cells of keratinocyte skin cancers
Kaukinen Antti, Siiskonen Harri, Pelkonen Jukka, Harvima Ilkka T. 2017. European journal of dermatology. 27: 590-598
Impact of lenalidomide-based induction therapy on the mobilization of CD34+ cells, blood graft cellular composition, and post-transplant recovery in myeloma patients: a prospective multicenter study
Partanen Anu, Valtola Jaakko, Silvennoinen Raija, Ropponen Antti, Siitonen Timo, Putkonen Mervi, Sankelo Marja, Pelkonen Jukka, Mäntymaa Pentti, Varmavuo Ville, Jantunen Esa. 2017. Transfusion. 57: 2366-2372
Preemptive plerixafor injection added to pegfilgrastim after chemotherapy in non-Hodgkin lymphoma patients mobilizing poorly
Partanen A, Valtola J, Ropponen A, Vasala K, Penttilä K, Ågren L, Pyörälä M, Nousiainen T, Selander T, Mäntymaa P, Pelkonen J, Varmavuo V, Jantunen E. 2017. Annals of hematology. 96: 1897-1906
RIP1 has a role in CD40-mediated apoptosis in human follicular lymphoma cells
Adem Jemal, Eray Mine, Eeva Jonna, Nuutinen Ulla, Pelkonen Jukka. 2017. Immunobiology. 222: 998-1003
Blood graft cellular composition and posttransplant outcomes in myeloma patients mobilized with or without low-dose cyclophosphamide: a randomized comparison
Valtola J, Silvennoinen R, Ropponen A, Siitonen T, Säily M, Sankelo M, Terävä V, Putkonen M, Kuittinen T, Pelkonen J, Mäntymaa P, Remes K, Varmavuo V, Jantunen E. 2016. Transfusion. 56: 1394-1401
Differential Expression of Bcl-2 Family Proteins Determines the Sensitivity of Human Follicular Lymphoma Cells to Dexamethasone-mediated and Anti-BCR-mediated Apoptosis
Adem Jemal, Ropponen Antti, Eeva Jonna, Eray Mine, Nuutinen Ulla, Pelkonen Jukka. 2016. Journal of immunotherapy. 39: 8-14
Early immune recovery after autologous transplantation in non-Hodgkin lymphoma patients: predictive factors and clinical significance
Valtola J, Varmavuo V, Ropponen A, Selander T, Kuittinen O, Kuitunen H, Keskinen L, Vasala K, Nousiainen T, Mäntymaa P, Pelkonen J, Jantunen E. 2016. Leukemia & lymphoma. 57: 2025-2032
Timing determines dexamethasone and rituximab induced synergistic cell death
Adem Jemal, Eraya Mine, Eeva Jonna, Nuutinen Ulla, Pelkonen Jukka. 2016. Molecular immunology. 75: 200-202
Blood MxA protein as a marker for respiratory virus infections in young children
Toivonen Laura, Schuez-Havupalo Linnea, Rulli Maris, Ilonen Jorma, Pelkonen Jukka, Melen Krister, Julkunen Ilkka, Peltola Ville, Waris Matti. 2015. Journal of clinical virology. 62: 8-13
Blood graft cellular composition and posttransplant recovery in non-Hodgkin's lymphoma patients mobilized with or without plerixafor: A prospective comparison
Valtola Jaakko, Varmavuo Ville, Ropponen Antti, Nihtinen Anne, Partanen Anu, Vasala Kaija, Lehtonen Päivi, Penttilä Karri, Pyörälä Marja, Kuittinen Taru, Silvennoinen Raija, Nousiainen Tapio, Pelkonen Jukka, Mäntymaa Pentti, Jantunen Esa. 2015. Transfusion. 55: 2358-2368
ERK1/2 has an essential role in B cell receptor- and CD40-induced signaling in an in vitro model of germinal center B cell selection
Adem Jemal, Hämäläinen Aleksi, Ropponen Antti, Eeva Jonna, Eray Mine, Nuutinen Ulla, Pelkonen Jukka. 2015. Molecular immunology. Volume 67, Issue 2, Part B: 240-247
Mast cells express CYP27A1 and CYP27B1 in epithelial skin cancers and psoriasis
Kaukinen Antti, Pelkoonen Jukka, Harvima Ilkka T. 2015. European journal of dermatology. [epub ahead of print]: -
Rituximab-induced early and late signaling have opposite effects on dexamethasone-induced apoptosis in human follicular lymphoma cells
Ademae Jemal, Ropponen Antti, Eeva Jonna, Eray Mine, Pelkonen Jukka, Nuutinen Ulla. 2015. Leukemia & lymphoma. 56: 2448-2457
Emergence of Klebsiella pneumoniae producing NDM-1 carbapenemase in Saint Petersburg, Russia
Barantsevich EP, Churkina IV, Barantsevich EP, Pelkonen J, Schlyakhto EV, Woodford N. 2013. Journal of antimicrobial chemotherapy. 68: 1204-6
Graft and outcome in autologous stem cell transplantation: a prospective GOA study
Jantunen E, Ropponen A, Siitonen T, Niittyvuopio R, Sankelo M, Putkonen M, Varmavuo V, Pyörälä M, Kuittinen T, Silvennoinen R, Kutila A, Nihtinen A, Vasala K, Lehtonen P, Sikiö A, Valonen P, Nousiainen T, Pelkonen J, Mäntymaa P. 2013. Bone marrow transplantation
Co-cultivated damp building related microbes trigger oxidative stress inducing cytotoxicity, DNA damage and inflammation in macrophages
Markkanen P, Pelkonen J, Mäki-Paakkanen J, Hirvonen M-R. 2011.
Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitro
Diaconu Nicolae-Costin, Rummukainen Jaana, Naukkarinen Anita, Mättö Mikko, Harvima Rauno J, Pelkonen Jukka, Harvima Ilkka T.. 2011. Archives of dermatological research. 303: 499-512
Lysosomal-mitochondrial axis in zoledronic acid-induced apoptosis in human follicular lymphoma cells
Mitrofan LM, Castells FB, Pelkonen J & Mönkkönen J. 2010. Journal of biological chemistry. 285: 1967 - 1979
Co-cultivated damp building related microbes Streptomyces californicus and Stachybotrys chartarum induce immunotoxic and genotoxic responses via oxidative stress
Markkanen P, Pelkonen J, Tapanainen M, Mäki-Paakkanen J, Jalava PI, Hirvonen M-R.. 2009. Inhalation toxicology. 21: 857-867
Co-cultivated damp building related microbes Streptomyces californicus and Stachybotrys chartarum induce immunotoxic and genotoxic responses via oxidative stress
Markkanen P, Pelkonen J, Tapanainen M, Mäki-Paakkanen J, Jalava PI, Hirvonen M-R. 2009. Inhalation toxicology. 21: 857-867
Dexamethasone-induced apoptosis and up-regulation of Bim is dependent on glycogen synthase kinase-3
Nuutinen U, Ropponen A, Suoranta S, Eeva J, Eray M, Pellinen R, Wahlfors J, Pelkonen J. 2009. Leukemia research. 33: 1714-1717
PDTC enables type I TRAIL signaling in type II follicular lymphoma cells
Nuutinen U, Simelius N, Ropponen A, Eeva J, Mättö M, Eray M, Pellinen R, Wahlfors J, Pelkonen J. 2009. Leukemia research. 33: 829-836
The effect of microenvironmental CD40 signals on TRAIL- and drug-induced apoptosis in follicular lymphoma cells
Nuutinen U, Ropponen A, Eeva J, Eray M, Pellinen R, Wahlfors J, Pelkonen J. 2009. Scandinavian journal of immunology. 70: 565-573
The involvement of mitochondria and the caspase-9 activation pathway in rituximab-induced apoptosis in FL cells
Eeva J, Nuutinen U, Ropponen A, Mättö M, Eray M, Pellinen R, Wahlfors J, Pelkonen J. 2009. Apoptosis. 14: 687-698
The level of ATP analog and isopentenyl pyrophosphate correlates with zoledronic acid-induced apoptosis in cancer cells in vitro
Mitrofan LM, Pelkonen J, Mönkkönen J. 2009. Bone. 45: 1153-1160
Cervical squamous carcinoma cells are resistant to the combined action of tumor necrosis factor-alpha and histamine whereas normal keratinocytes undergo cytolysis
Diaconu N-C, Rummukainen J, Mättö M, Naukkarinen A, Harvima RJ, Pelkonen J, Harvima IT. 2008. Bmc cancer. 8: [15, art. 46]
Human B cells and macrophages cooperate in T-cell-independent type 2 response
Mättö M, Raunio A-R, Postila V, Huttunen K, Hirvonen M-R, Pelkonen J. 2008. Scandinavian journal of immunology. 67: 209-217
Regulation of repertoire development through genetic control of Dh reading frame preference
Zemlin M, Schelonka RL, Ippolito GC, Zemlin C, Zhuang Y, Gartland GL, Nitschke L, Pelkonen J, Rajewsky K, Schroeder HW Jr.. 2008. Journal of immunology. 181: 8416-8424
Brefeldin a triggers apoptosis associated with mitochondrial breach and enhances HA14-1- and anti-Fas-mediated cell killing in follicular lymphoma cells
Wlodkowic D, Skommer J, Pelkonen J. 2007. Leukemia research. 31: 1687-1700
CXCR4 expression during tumour cell death
Skommer J, Wlodkowic D, Pelkonen J. 2007. Leukemia research
DNA damage and p53 in RAW264.7 cells induced by the spores of co-cultivated Streptomyces californicus and Stachybotrys chartarum
Penttinen P, Tampio M, Mäki-Paakkanen J, Vähäkangas K, Pelkonen J, Hirvonen MR. 2007. Toxicology. 235: 92-102
Gene-expression profiling during curcumin-induced apoptosis reveaös downregulation of CXCR4
Skommer J, Wlodkowic D, Pelkonen J. 2007. Experimental hematology. 35: 84-95
The CD40-induced protection against CD95-mediated apoptosis is associated with a rapid upregulation of anti-apoptotic c-FLIP
Eeva J, Ropponen A, Nuutinen U, Eeva S-T, Mättö M, Eray M. 2007. Molecular immunology. 44: 1230-1237
Towards an understanding of apoptosis detection by SYTO dyes
Wlodkowic D, Skommer J, Pelkonen J. 2007. Cytometry part a. 71A: 61-72
Cellular foundation of curcumin-induced apoptosis in follicular lymphoma cell lines
Skommer J, Wlodkowic D, Pelkonen J. 2006. Experimental hematology. 34: 463-474
Co-cultivation of Streptomyces californicus and Stachybotrys chartarum stimulates the production of cytostatic compound(s) with immunotoxic properties
Penttinen P, Pelkonen J, Huttunen K, Hirvonen M-R. 2006. Toxicology and applied pharmacology. 217: 342-351
Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production
Ippolito GC, Schelonka RL, Zemlin M, Ivanov II, Kobayashi R, Zemlin C, Cartland GL, Nitschke L, Pelkonen J, Fujihashi K, Rajewsky K, Shroeder Jr HW. 2006. Journal of experimental medicine. 203: 1567-1578
HA 14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells
Skommer J, Wlodkowic D, Mättö M, Eray M, Pelkonen J. 2006. Leukemia research. 30: 322-331
Inhibition of P13-kinase-Akt pathway enhances dexamethasone-induced apoptosis in a human follicular lymphoma cell line
Nuutinen U, Postila V, Mättö M, Eeva J, Ropponen A, Eray M, Riikonen P, Pelkonen J. 2006. Experimental cell research. 312: 322-330
Multiparametric analysis of HA14-1-induced apoptosis in follicular lymphoma cells
Wlodkowic D, Skommer J, Pelkonen J. 2006. Leukemia research. 30: 1187-1192
CD45RA and RO isoforms have distinct effects on cytokine- and B-cell-receptor-mediated signalling in human B cells
Mättö M, Nuutinen U-M, Ropponen A, Myllykangas K, Pelkonen J. 2005. Scandinavian journal of immunology. 61: 520-528
Interactions between Streptomyces californicus and Stachybotrys chartarum can induce apoptosis and cell cycle arrest in mouse RAW264.7 macrophages
Penttinen P, Pelkonen J, Huttunen K, Toivola M, Hirvonen M-R. 2005. Toxicology and applied pharmacology. 202: 278-288
The proportions of Streptomyces californicus and Stachybotrys chartarum in simultaneous exposure affect inflammatory responses in mouse
Penttinen P, Huttunen K, Pelkonen J, Hirvonen M-R. 2005. Inhalation toxicology. 17: 79-85
Apoptosis induced by ultraviolet radiation is enhanced by amplitude modulated radiofrequency radiation in mutant yeast cells
Markkanen A, Penttinen P, Naarala J, Pelkonen J, Sihvonen A-P, Juutilainen J. 2004. Bioelectromagnetics. 25: 127-133
Heparin modulates the growth and adherence and augments the gowth-inhibitory action of TNF-alpha on cultured human keratinocytes
Harvima IT, Lappalainen K, Hirvonen MR, Matto M, Kivinen PK, Hyttinen M, Pelkonen J, Naukkarinen A. 2004. Journal of cellular biochemistry. 92: 372-386
Human in vivo-activated CD45R0+ CD4+ T cells are susceptible to spontaneous apoptosis that can be inhibited by the chemokine CXCL12 and IL-2, -6, -7, and -15
Pajusto M, Ihalainen N, Pelkonen J, Tarkkanen J, Mattila PS. 2004. European journal of immunology. 34: 2771-2780
Mechanisms of B cell receptor induced apoptosis
Eeva J, Pelkonen J. 2004. Apoptosis. 9: 525-531
Neural retina limits the nonviral gene transfer to retinal pigment epithelium in an vitro bovine eye model
Pitkänen L, Pelkonen J, Ruponen M, Rönkkö S, Urtti A. 2004. AAPS journal. 6: 1-9
Starch acetate microparticles for drug delivery into retinal pigment epithelium - in vitro study
Tuovinen L, Ruhanen E, Kinnarinen T, Rönkkö S, Pelkonen J, Urtti A, Peltonen S, Järvinen K. 2004. Journal of controlled release. 98: 407-413
Synergistic interaction in simultaneous exposure to Streptomyces californicus and Stachybotrys chartarum
Huttunen K, Pelkonen J, Nielsen KF, Nuutinen U, Jussila J, Hirvonen M-R. 2004. Environmental health perspectives. 112: 659-665
Antibody repertoire in a mouse with a simplified DH locus: the D-limited mouse
Ippolito GC, Pelkonen J, Nitschke L, Rajewsky K, Schroeder HW Jr. 2003. Annals of the New York Academy of Sciences. 987: 262-265
Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia
Jumaa H, Bossaller L, Portugal K, Storch B, Lotz M, Flemming A, Schrappe M, Postila V, Riikonen P, Pelkonen J, Niemeyer C, Reth M. 2003. Nature. 423: 452-456
Extracellular and intracellular barriers in non-viral gene delivery
Ruponen M, Honkakoski P, Rönkkö S, Pelkonen J, Tammi M, Urtti A. 2003. Journal of controlled release. 93: 213-217
Follicular lymphoma cell lines, an in vitro model for antigenic selection and cytokine-mediated growth regulation of germinal centre B cells
Eray M, Postila V, Eeva J, Ripatti A, Karjalainen-Lindsberg M-L, Knuutila S, Andersson LC, Pelkonen J. 2003. Scandinavian journal of immunology. 57: 545-555
Joint symptoms and diseases associated with moisture damage in a health center
Luosujärvi RA, Husman TM, Seuri M, Pietikäinen MA, Pollari P, Pelkonen J, Hujakka HT, Kaipiainen-Seppänen OA, Aho K. 2003. Clinical rheumatology. 22: 381-385
Kinetics and signaling requirements of CD40-mediated protection from B cell receptor-induced apoptosis
Eeva J, Postila V, Mättö M, Nuutinen U, Ropponen A, Eray M, Pelkonen J. 2003. European journal of immunology. 33: 2783-2791
Systemic immunoresponses in mice after repeated exposure of lungs to spores of Streptomyces californicus
Jussila J, Pelkonen J, Kosma V-M, Mäki-Paakkanen J, Komulainen H, Hirvonen M-R. 2003. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY. 10: 30-37
Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan synthase 2 (Has2) genes
Rilla K, Lammi MJ, Sironen R, Törrönen K, Luukkonen M, Hascall VC, Midura RJ, Hyttinen M, Pelkonen J, Tammi M, Tammi R. 2002. Journal of cell science. 115: 3633-3643
Inflammatory potential of the spores of Penicillium spinulosum isolated from indoor air of a moisture-damaged building in mouse lungs
Jussila J, Komulainen H, Kosma V-M, Pelkonen J, Hirvonen M-R. 2002. Environmental toxicology and pharmacology. 12: 137-145
Mycobacterium terrae isolated from indoor air of a moisture-damaged building induces sustained biphasic inflammatory response in mouse lungs
Jussila J, Komulainen H, Huttunen K, Roponen M, Iivanainen E, Torkko P, Kosma V-M, Pelkonen J, Hirvonen M-R. 2002. Environmental health perspectives. 110: 1119-1125
Spores of Aspergillus versicolor isolated from indoor air of a moisture-damaged building provoke acute inflammation in mouse lungs
Jussila J, Komulainen H, Kosma V-M, Nevalainen A, Pelkonen J, Hirvonen M-R. 2002. Inhalation toxicology. 14: 1261-1277
Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene
Liippo J, Nera K-P, Veistinen E, Lähdesmäki A, Postila V, Kimby E, Riikonen P, Hammarström L, Pelkonen J, Lassila O. 2001. European journal of immunology. 31: 3469-3474
Deletion of the DQ52 element within the Ig heavy chain locus leads to a selective reduction in VDJ recombination and altered D gene usage
Nitschke L, Kestler J, Tallone T, Pelkonen S, Pelkonen J. 2001. Journal of immunology. 166: 2540-2552
Effects of 50 Hz magnetic field on cell cycle kinetics and the colony forming ability of budding yeast exposed to ultraviolet radiation
Markkanen A, Juutilainen J, Lang S, Pelkonen J, Rytömaa T, Naarala J. 2001. Bioelectromagnetics. 22: 345-350
Extracellular glycosaminoglycans modify cellular trafficking of lipoplexes and polyplexes
Ruponen M, Rönkkö S, Honkakoski P, Pelkonen J, Tammi M, Urtti A. 2001. Journal of biological chemistry. 276: 33875-33880
Flow cytometric analysis of apoptotic subpopulatios with a combination of Annexin V-FITC, propidium iodide, and SYTO 17
Eray M, Mättö M, Kaartinen M, Andersson LC, Pelkonen J. 2001. Cytometry part a. 43: 134-142
Inflammatory responses in mice after intratracheal instillation of spores of streptomyces californicus isolated from indoor air of a molby building
Jussila J, Komulainen H, Huttunen K, Roponen M, Hälinen A, Hyvärinen A, Kosma V-M, Pelkonen J, Hirvonen M-R. 2001. Toxicology and applied pharmacology. 171: 61-69
Development of tuberculin reactivity and sensitization to M. Scrofulaceum and M. Fortuitum in children BCG-vaccinated at birth
Kröger L, Korppi M, Pelkonen J, Pietikäinen M, Katila M-L. 2000. European respiratory journal. 15: 382-387
T-lymphocyte subpopulations do not express identical combinations of interleukin-2 receptor chains in the early phase of their activation and proliferation
Perola O, Ripatti A, Pelkonen J. 2000. Scandinavian journal of immunology. 52: 123-130
Early activation of TCR alpha gene rearrangement in fetal thymocytes
Rytkönen-Nissinen M, Hurwitz JL, Pelkonen S, Levelt C, Pelkonen J. 1999. European journal of immunology. 29: 2288-2296
Mast cells in psoriatic skin are strongly positive for interferon-gamma
Ackermann L, Harvima IT, Pelkonen J, Ritamäki-Salo V, Naukkarinen A, Harvima RJ, Horsmanheimo M. 1999. British journal of dermatology. 140: 624-633
Mast cells of psoriatic skin are strongly positive for interferon-gamma
Ackermann L, Harvima I T, Pelkonen J, Ritamäki-salo V, Naukkarinen A, Harvima R J, Horsmanheimo M. 1999. British journal of dermatology. 140: 624-633
Kinetics of cytokine and NFAT gene expression in human interleukin-2-dependent T lymphoblasts stimulated via T-cell receptor
Sareneva T, Matikainen S, Vanhatalo J, Melén K, Pelkonen J, Julkunen I. 1998. Immunology. 93: 350-357
Staphylococcal enterotoxin B inhibits the production of interleukin-4 in a human mast-cell line HMC-1
Ackermann L, Pelkonen J, Harvima IT. 1998. Immunology. 94: 247-252
Complementary DNA cloning of the predominant allergen of bovine dander: A new member in the lipocalin family
Mäntyjärvi R, Parkkinen S, Rytkönen M, Pentikäinen J, Pelkonen J, Rautiainen J, Zeiler T, Virtanen T. 1996. Journal of allergy and clinical immunology. 97: 1297-1303
Immune reactivity of cow-asthmatic dairy farmers to the major allergen of cow (BDA20) and to other cow-derived proteins. The use of purified BDA20 increases the performance of diagnostic tests in respiratory cow allergy
Virtanen T, Zeiler T, Rautiainen J, Taivainen A, Pentikäinen J, Rytkönen M, Parkkinen S, Pelkonen J, Mäntyjärvi R. 1996. Clinical and experimental allergy. 26: 188-196
Molecular analysis of allergenic proteins in bovine dander
Rautiainen J, Pentikäinen J, Rytkönen M, Linnala-Kankkunen A, Pelkonen J, Virtanen T, Mäntyjärvi R. 1996. Allergy. 51: 378-382
Restricted onset of T cell receptor alfa gene rearrangement in fetal and neonatal thymocytes
Rytkönen MA, Hurwitz JL, Thompson SD, Pelkonen J. 1996. European journal of immunology. 26: 1892-1896
cDNA cloning and molecular characterization of bovine dander allergens
Mäntyjärvi RA, Parkkinen S, Rytkönen M, Pentikäinen J, Pelkonen J, Rautiainen J, Zeiler T, Virtanen T. Teoksessa: Basomba A, Hernandez F. de Rojas(toim.) , 1995. XVI European Congress of Allergology and Clinical Immunnlogy ECACI 95. s. 111-115. Monduzzi
cDNA cloning and protein analysis of a bovine dermal allergen with homology to psoriasin
Rautiainen J, Rytkönen M, Parkkinen S, Pentikäinen J, Linnala-Kankkunen A, Virtanen T, Pelkonen J, Mäntyjärvi R. 1995. Journal of investigative dermatology. 105: 660-663
Evidence for recombinatorial hot spots at the T cell receptor Jalpha locus
Rytkönen MA, Hurwitz J L.,Tolonen K & Pelkonen J. 1994. European journal of immunology. 24: 107-115
First T-cell receptor a gene rearrangements during T-cell ontogeny skew to the 5' region of the Ja locus
Thompson SD, Pelkonen J, Hurwitz JL. 1990. Journal of immunology. 145: 2347-2352
LD-1: A CD4-8-TCRab/CD3+ peripheral T cell line with helper function for B lymphocytes
Pelkonen J, Palacios R. 1990. . 2: 555-562
Non-random rearrangement of T-cell receptor J-alpha genes in bone marrow T-differentation cultures
Thompson SD, Pelkonen J, Rytkönen M, Samaridis J, Hurwitz JL. 1990. Journal of immunology. 144: 2829-2834

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Jukka Pelkonen

Research groups

Loss of CD34+ Cells and Effect of the Number of Viable Cryopreserved CD34+ Cells in the Infused Blood Grafts on Hematologic Recovery, Progression-Free Survival and Overall Survival in NHL Patients After Autologous Stem Cell Transplantation

Impact of the number of cryopreserved CD34+ cells in the infused blood grafts on hematologic recovery and survival in myeloma patients after autologous stem cell transplantation: Experience from the GOA study

Autograft cellular composition and outcome in myeloma patients: Results of the prospective multicenter GOA study

Blood Graft and Outcome After Autologous Stem Cell Transplantation in Patients With Primary Central Nervous System Lymphoma

Comparison of CD34 + cell mobilization, blood graft cellular composition, and post-transplant outcome in myeloma patients mobilized with filgrastim or pegfilgrastim added to low-dose cyclophosphamide: A prospective multicenter study

A prospective comparison of pegfilgrastim and lipegfilgrastim combined with chemotherapy in the mobilization of CD34+ cells in NHL patients

Autograft cellular composition and outcome in NHL patients: results of the prospective multicenter GOA study

Autologous stem cell transplantation in peripheral T-cell lymphoma: better mobilization of blood CD34 + cells is associated with improved survival

Mobilization characteristics, blood graft composition, and outcome in diffuse large B-cell lymphoma after autologous stem cell transplantation: Results from the prospective multicenter GOA study

Pleriksafori kantasolujen mobilisaatiossa autologista siirtoa varten

Importance of early immune recovery after autologous hematopoietic cell transplantation in lymphoma patients

Mast Cells Are a Marked Source for Complement C3 Products That Associate with Increased CD11b-Positive Cells in Keratinocyte Skin Carcinomas

Blood graft composition and post-transplant recovery in myeloma patients mobilized with plerixafor: a prospective multicenter study

Comparison of filgrastim, pegfilgrastim, and lipegfilgrastim added to chemotherapy for mobilization of CD34+ cells in non-Hodgkin lymphoma patients

The combination of TRAIL and MG-132 induces apoptosis in both TRAIL-sensitive and TRAIL-resistant human follicular lymphoma cells

Advantages of targeting B cell receptor complex to treat B-cell derived autoimmune diseases and lymphomas

CD40 Ligand Is Increased in Mast Cells in Psoriasis and Actinic Keratosis but Less So in Epithelial Skin Carcinomas

Immunoreactivity to CYP24A1, but not vitamin D receptor, is increased in mast cells of keratinocyte skin cancers

Impact of lenalidomide-based induction therapy on the mobilization of CD34+ cells, blood graft cellular composition, and post-transplant recovery in myeloma patients: a prospective multicenter study

Preemptive plerixafor injection added to pegfilgrastim after chemotherapy in non-Hodgkin lymphoma patients mobilizing poorly

RIP1 has a role in CD40-mediated apoptosis in human follicular lymphoma cells

Blood graft cellular composition and posttransplant outcomes in myeloma patients mobilized with or without low-dose cyclophosphamide: a randomized comparison

Differential Expression of Bcl-2 Family Proteins Determines the Sensitivity of Human Follicular Lymphoma Cells to Dexamethasone-mediated and Anti-BCR-mediated Apoptosis

Early immune recovery after autologous transplantation in non-Hodgkin lymphoma patients: predictive factors and clinical significance

Timing determines dexamethasone and rituximab induced synergistic cell death

Blood MxA protein as a marker for respiratory virus infections in young children

Blood graft cellular composition and posttransplant recovery in non-Hodgkin's lymphoma patients mobilized with or without plerixafor: A prospective comparison

ERK1/2 has an essential role in B cell receptor- and CD40-induced signaling in an in vitro model of germinal center B cell selection

Mast cells express CYP27A1 and CYP27B1 in epithelial skin cancers and psoriasis

Rituximab-induced early and late signaling have opposite effects on dexamethasone-induced apoptosis in human follicular lymphoma cells

Emergence of Klebsiella pneumoniae producing NDM-1 carbapenemase in Saint Petersburg, Russia

Graft and outcome in autologous stem cell transplantation: a prospective GOA study

Co-cultivated damp building related microbes trigger oxidative stress inducing cytotoxicity, DNA damage and inflammation in macrophages

Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitro

Lysosomal-mitochondrial axis in zoledronic acid-induced apoptosis in human follicular lymphoma cells

Co-cultivated damp building related microbes Streptomyces californicus and Stachybotrys chartarum induce immunotoxic and genotoxic responses via oxidative stress

Co-cultivated damp building related microbes Streptomyces californicus and Stachybotrys chartarum induce immunotoxic and genotoxic responses via oxidative stress

Dexamethasone-induced apoptosis and up-regulation of Bim is dependent on glycogen synthase kinase-3

PDTC enables type I TRAIL signaling in type II follicular lymphoma cells

The effect of microenvironmental CD40 signals on TRAIL- and drug-induced apoptosis in follicular lymphoma cells

The involvement of mitochondria and the caspase-9 activation pathway in rituximab-induced apoptosis in FL cells

The level of ATP analog and isopentenyl pyrophosphate correlates with zoledronic acid-induced apoptosis in cancer cells in vitro

Cervical squamous carcinoma cells are resistant to the combined action of tumor necrosis factor-alpha and histamine whereas normal keratinocytes undergo cytolysis

Human B cells and macrophages cooperate in T-cell-independent type 2 response

Regulation of repertoire development through genetic control of Dh reading frame preference

Brefeldin a triggers apoptosis associated with mitochondrial breach and enhances HA14-1- and anti-Fas-mediated cell killing in follicular lymphoma cells

CXCR4 expression during tumour cell death

DNA damage and p53 in RAW264.7 cells induced by the spores of co-cultivated Streptomyces californicus and Stachybotrys chartarum

Gene-expression profiling during curcumin-induced apoptosis reveaös downregulation of CXCR4

The CD40-induced protection against CD95-mediated apoptosis is associated with a rapid upregulation of anti-apoptotic c-FLIP

Towards an understanding of apoptosis detection by SYTO dyes

Cellular foundation of curcumin-induced apoptosis in follicular lymphoma cell lines

Co-cultivation of Streptomyces californicus and Stachybotrys chartarum stimulates the production of cytostatic compound(s) with immunotoxic properties

Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production

HA 14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells

Inhibition of P13-kinase-Akt pathway enhances dexamethasone-induced apoptosis in a human follicular lymphoma cell line

Multiparametric analysis of HA14-1-induced apoptosis in follicular lymphoma cells

CD45RA and RO isoforms have distinct effects on cytokine- and B-cell-receptor-mediated signalling in human B cells

Interactions between Streptomyces californicus and Stachybotrys chartarum can induce apoptosis and cell cycle arrest in mouse RAW264.7 macrophages

The proportions of Streptomyces californicus and Stachybotrys chartarum in simultaneous exposure affect inflammatory responses in mouse

Apoptosis induced by ultraviolet radiation is enhanced by amplitude modulated radiofrequency radiation in mutant yeast cells

Heparin modulates the growth and adherence and augments the gowth-inhibitory action of TNF-alpha on cultured human keratinocytes

Human in vivo-activated CD45R0+ CD4+ T cells are susceptible to spontaneous apoptosis that can be inhibited by the chemokine CXCL12 and IL-2, -6, -7, and -15

Mechanisms of B cell receptor induced apoptosis

Neural retina limits the nonviral gene transfer to retinal pigment epithelium in an vitro bovine eye model

Starch acetate microparticles for drug delivery into retinal pigment epithelium - in vitro study

Synergistic interaction in simultaneous exposure to Streptomyces californicus and Stachybotrys chartarum

Antibody repertoire in a mouse with a simplified DH locus: the D-limited mouse

Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia

Extracellular and intracellular barriers in non-viral gene delivery

Follicular lymphoma cell lines, an in vitro model for antigenic selection and cytokine-mediated growth regulation of germinal centre B cells

Joint symptoms and diseases associated with moisture damage in a health center

Kinetics and signaling requirements of CD40-mediated protection from B cell receptor-induced apoptosis

Systemic immunoresponses in mice after repeated exposure of lungs to spores of Streptomyces californicus

Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan synthase 2 (Has2) genes

Inflammatory potential of the spores of Penicillium spinulosum isolated from indoor air of a moisture-damaged building in mouse lungs

Mycobacterium terrae isolated from indoor air of a moisture-damaged building induces sustained biphasic inflammatory response in mouse lungs