Jussi Pihlajamäki

Associations of Lifestyle Patterns with Glucose and Lipid Metabolism in Finnish Adults at Increased Risk of Type 2 Diabetes

Manninen, Suvi; Tilles‐Tirkkonen, Tanja; Aittola, Kirsikka; Männikkö, Reija; Karhunen, Leila; Kolehmainen, Marjukka; Schwab, Ursula; Lindström, Jaana; Lakka, Timo; Pihlajamäki, Jussi; the Stop Diabetes study group. 2024. Molecular nutrition and food research. 68:

Dietary n-3 alpha-linolenic and n-6 linoleic acids modestly lower serum lipoprotein(a) concentration but differentially influence other atherogenic lipoprotein traits: A randomized trial

Nuotio, Petrus; Lankinen, Maria A; Meuronen, Topi; de Mello, Vanessa D; Sallinen, Taisa; Virtanen, Kirsi A; Pihlajamäki, Jussi; Laakso, Markku; Schwab, Ursula. 2024. Atherosclerosis. 395:

Effectiveness of workplace choice architecture modification for healthy eating and daily physical activity

Rantala, Eeva; Vanhatalo, Saara; Valtanen, Mikko; Lindström, Jaana; Pihlajamäki, Jussi; Poutanen, Kaisa; Absetz, Pilvikki; Karhunen, Leila. 2024. Bmc public health. 24: . 939

Hepatokine ITIH3 protects against hepatic steatosis by downregulating mitochondrial bioenergetics and de novo lipogenesis

Talari, Noble Kumar; Mattam, Ushodaya; Kaminska, Dorota; Sotomayor-Rodriguez, Irene; Rahman, Afra P.; Péterfy, Miklós; Pajukanta, Päivi; Pihlajamäki, Jussi; Chella Krishnan, Karthickeyan. 2024. iScience. 27: . 109709

IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids

Sasidharan, Kavitha; Caddeo, Andrea; Jamialahmadi, Oveis; Noto, Francesca Rita; Tomasi, Melissa; Malvestiti, Francesco; Ciociola, Ester; Tavaglione, Federica; Mancina, Rosellina M.; Cherubini, Alessandro; Bianco, Cristiana; Mirarchi, Angela; Männistö, Ville; Pihlajamäki, Jussi; Kärjä, Vesa; Grimaudo, Stefania; Luukkonen, Panu K.; Qadri, Sami; Yki-Järvinen, Hannele; Petta, Salvatore; Manfrini, Silvia; Vespasiani-Gentilucci, Umberto; Bruni, Vincenzo; Valenti, Luca; Romeo, Stefano. 2024. Cell reports medicine. 5:

Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity

Matilainen, Johanna; Berg, Viivi; Vaittinen, Maija; Impola, Ulla; Mustonen, Anne-Mari; Männistö, Ville; Malinen, Marjo; Luukkonen, Veera; Rosso, Natalia; Turunen, Tanja; Käkelä, Pirjo; Palmisano, Silvia; Arasu, Uma Thanigai; Sihvo, Sanna P.; Aaltonen, Niina; Härkönen, Kai; Caddeo, Andrea; Kaminska, Dorota; Pajukanta, Päivi; Kaikkonen, Minna U.; Tiribelli, Claudio; Käkelä, Reijo; Laitinen, Saara; Pihlajamäki, Jussi; Nieminen, Petteri; Rilla, Kirsi. 2024. Journal of translational medicine. 22: . 623

Modification in mitochondrial function is associated with the FADS1 variant and its interaction with alpha-linolenic acid-enriched diet - an exploratory study

Vaittinen, Maija; Ilha, Mariana; Sehgal, Ratika; Lankinen, Maria A; Ågren, Jyrki; Käkelä, Pirjo; Virtanen, Kirsi A; Laakso, Markku; Schwab, Ursula; Pihlajamäki, Jussi. 2024. Journal of lipid research. 65:

Protein Phosphatase 1 Regulatory Subunit 3 Beta rs4240624 Genotype Is Associated With Gallstones and With Significant Changes in Bile Lipidome

Männistö, Ville T; Kaminska, Dorota; Haal, Sylke; Asteljoki, Juho; Luukkonen, Panu K; Käkelä, Pirjo; Tavaglione, Federica; van Weeghel, Michel; Neuvonen, Mikko; Niemi, Mikko; Romeo, Stefano; Nieuwdorp, Max; Pihlajamäki, Jussi; Groen, Albert K. 2024. Gastro hep advances. 3: 594-601

Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease

Lee, Seung Hyuk T; Garske, Kristina M; Arasu, Uma Thanigai; Kar, Asha; Miao, Zong; Alvarez, Marcus; Koka, Amogha; Darci-Maher, Nicholas; Benhammou, Jihane N; Pan, David Z; Örd, Tiit; Kaminska, Dorota; Männistö, Ville; Heinonen, Sini; Wabitsch, Martin; Laakso, Markku; Agopian, Vatche G; Pisegna, Joseph R; Pietiläinen, Kirsi H; Pihlajamäki, Jussi; Kaikkonen, Minna U; Pajukanta, Päivi. 2024. EBioMedicine. 106: . 105232

Temporal Alterations in CD8+ T Cells During the Progression from Stage 1 to Stage 3 Type 1 Diabetes

Schroderus, Anna-Mari; Pitkänen, Viola; Ekman, Ilse; Stevens, Daniella; Rytkönen-Nissinen, Marja; Rintamäki, Reeta; Pihlajamäki, Jussi; Knip, Mikael; Veijola, Riitta; Toppari, Jorma; Ilonen, Jorma; Lempainen, Johanna; Kinnunen, Tuure. 2024. Diabetes. 73: 1705-1715

m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1

Xiao, Ling; De Jesus, Dario F; Ju, Cheng-Wei; Wei, Jiang Bo; Hu, Jiang; DiStefano-Forti, Ava; Tsuji, Tadataka; Cero, Cheryl; Männistö, Ville; Manninen, Suvi M; Wei, Siying; Ijaduola, Oluwaseun; Blüher, Matthias; Cypess, Aaron M; Pihlajamäki, Jussi; Tseng, Yu-Hua; He, Chuan; Kulkarni, Rohit N. 2024. Cell metabolism. 36: 2207-2227.e9

Acceptability of workplace choice architecture modification for healthy behaviours

Rantala, Eeva; Vanhatalo, Saara; Perez-Cueto, Federico J A; Pihlajamäki, Jussi; Poutanen, Kaisa; Karhunen, Leila; Absetz, Pilvikki. 2023. Bmc public health. 23: . 2451

Associations Between Engagement with the BitHabit Digital Lifestyle Intervention and Changes in Type 2 Diabetes Risk Factors

Liedes, Hilkka; Mattila, Elina; Honka, Anita; Absetz, Pilvikki; Aittola, Kirsikka; Manninen, Suvi; Lintu, Niina; Schwab, Ursula; Eloranta, Aino-Maija; Umer, Adil; Tilles-Tirkkonen, Tanja; Männikkö, Reija; Ruotsalainen, Ilona; Van Gils, Mark; Lindström, Jaana; Lakka, Timo; Pihlajamäki, Jussi; Vuorinen, Anna-Leena. 2023. Studies in health technology and informatics

Changes in liver metabolic pathways demonstrate efficacy of the combined dietary and microbial therapeutic intervention in MASLD mouse model

Iannone, Valeria; Babu, Ambrin Farizah; Lok, Johnson; Gómez-Gallego, Carlos; D’Auria, Giuseppe; Vazquez-Uribe, Ruben; Vaaben, Troels Holger; Bongers, Mareike; Mikkonen, Santtu; Vaittinen, Maija; Tikkanen, Ida; Kettunen, Mikko; Klåvus, Anton; Sehgal, Ratika; Kaminska, Dorota; Pihlajamaki, Jussi; Hanhineva, Kati; El-Nezami, Hani; Alexander Sommer, Morten Otto; Kolehmainen, Marjukka. 2023. Molecular metabolism. 78:

Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans

U-Din, Mueez; de Mello, Vanessa D; Tuomainen, Marjo; Raiko, Juho; Niemi, Tarja; Fromme, Tobias; Klåvus, Anton; Gautier, Nadine; Haimilahti, Kimmo; Lehtonen, Marko; Kristiansen, Karsten; Newman, John W; Pietiläinen, Kirsi H; Pihlajamäki, Jussi; Amri, Ez-Zoubir; Klingenspor, Martin; Nuutila, Pirjo; Pirinen, Eija; Hanhineva, Kati; Virtanen, Kirsi A. 2023. Cell reports. 42:

Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease

Darci-Maher, Nicholas; Alvarez, Marcus; Arasu, Uma Thanigai; Selvarajan, Ilakya; Lee, Seung Hyuk T.; Pan, David Z.; Miao, Zong; Das, Sankha Subhra; Kaminska, Dorota; Örd, Tiit; Benhammou, Jihane N.; Wabitsch, Martin; Pisegna, Joseph R.; Männistö, Ville; Pietiläinen, Kirsi H.; Laakso, Markku; Sinsheimer, Janet S.; Kaikkonen, Minna U.; Pihlajamäki, Jussi; Pajukanta, Päivi. 2023. EBioMedicine. 92:

Dekaanin tervehdys

Pihlajamäki, Jussi. 2023. Publications of the University of Eastern Finland. General series. 44: 13-14

Evaluation of plasma IL-21 as a potential biomarker for type 1 diabetes progression

Schroderus, Anna-Mari; Poorbaugh, Josh; McElyea, Samantha; Beasley, Stephanie; Zhang, Lin; Näntö-Salonen, Kirsti; Rintamäki, Reeta; Pihlajamäki, Jussi; Knip, Mikael; Veijola, Riitta; Toppari, Jorma; Ilonen, Jorma; Benschop, Robert J; Kinnunen, Tuure. 2023. Frontiers in immunology. 14: . 1157265

High estradiol levels during a long agonist IVF protocol are associated with decreased food intake, higher leptin concentrations, and lower levels of high-sensitivity C-reactive protein

Leppänen, Jonna; Nuotio, Petrus; Randell, Kaisa; Romppanen, Jarkko; Keski-Nisula, Leea; Laitinen, Tomi; Pihlajamäki, Jussi; Schwab, Ursula; Heinonen, Seppo. 2023. Archives of gynecology and obstetrics. 308: 883-891

Liraglutide demonstrates a therapeutic effect on mitochondrial dysfunction in human SGBS adipocytes in vitro

Vaittinen, Maija; Ilha, Mariana; Herbers, Elena; Wagner, Anita; Virtanen, Kirsi A; Pietiläinen, Kirsi H; Pirinen, Eija; Pihlajamäki, Jussi. 2023. Diabetes research and clinical practice. 199:

Liver saturated fat content associates with hepatic DNA methylation in obese individuals

Sehgal, Ratika; Perfilyev, Alexander; Männistö, Ville; Ågren, Jyrki; Nilsson, Emma; Käkelä, Pirjo; Ling, Charlotte; de Mello, Vanessa D.; Pihlajamäki, Jussi. 2023. Clinical epigenetics. 15: . 21

Programmed cell death 1 genetic variant and liver damage in nonalcoholic fatty liver disease

Pipitone, Rosaria M.; Malvestiti, Francesco; Pennisi, Grazia; Jamialahmadi, Oveis; Dongiovanni, Paola; Bertolazzi, Giorgio; Pihlajamäki, Jussi; Yki‐Järvinen, Hannele; Vespasiani‐Gentilucci, Umberto; Tavaglione, Federica; Maurotti, Samantha; Bianco, Cristiana; Di Maria, Gabriele; Enea, Marco; Fracanzani, Anna L.; Kärjä, Vesa; Lupo, Giulia; Männistö, Ville; Meroni, Marica; Piciotti, Roberto; Qadri, Sami; Zito, Rossella; Craxì, Antonio; Di Marco, Vito; Cammà, Calogero; Tripodo, Claudio; Valenti, Lu. 2023. Liver international. 43: 1761-1771

“Role of Matrix Gla Protein in Transforming Growth Factor-β Signaling and Non-Alcoholic Steatohepatitis in Mice”

Hui, Simon T; Gong, Lili; Swichkow, Chantle; Blencowe, Montgomery; Kaminska, Dorota; Diamante, Graciel; Pan, Calvin; Dalsania, Meet; French, Samuel W; Magyar, Clara E; Pajukanta, Päivi; Pihlajamäki, Jussi; Boström, Kristina I; Yang, Xia; Lusis, Aldons J. 2023. Cellular and molecular gastroenterology and hepatology. 16: 943-960

Associations between weight loss history and factors related to type 2 diabetes risk in the Stop Diabetes study

Halali, F; Lapveteläinen, A; Aittola, K; Männikkö, R; Tilles-Tirkkonen, T; Järvelä-Reijonen, E; Absetz, P; Kolehmainen, M; Schwab, U; Lindström, J; Lakka, TA; Pihlajamäki, J; Karhunen, L. 2022. International journal of obesity. 46: 935-942

Digitally Supported Lifestyle Intervention to Prevent Type 2 Diabetes Through Healthy Habits: Secondary Analysis of Long-Term User Engagement Trajectories in a Randomized Controlled Trial

Lavikainen, Piia; Mattila, Elina; Absetz, Pilvikki; Harjumaa, Marja; Lindström, Jaana; Järvelä-Reijonen, Elina; Aittola, Kirsikka; Männikkö, Reija; Tilles-Tirkkonen, Tanja; Lintu, Niina; Lakka, Timo; van Gils, Mark; Pihlajamäki, Jussi; Martikainen, Janne. 2022. Journal of medical internet research. 24:

Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease

Luukkonen, Panu K; Qadri, Sami; Ahlholm, Noora; Porthan, Kimmo; Männistö, Ville; Sammalkorpi, Henna; Penttilä, Anne K; Hakkarainen, Antti; Lehtimäki, Tiina E; Gaggini, Melania; Gastaldelli, Amalia; Ala-Korpela, Mika; Orho-Melander, Marju; Arola, Johanna; Juuti, Anne; Pihlajamäki, Jussi; Hodson, Leanne; Yki-Järvinen, Hannele. 2022. Journal of hepatology. 76: 526-535

Identification of 90 NAFLD GWAS loci and establishment of NAFLD PRS and causal role of NAFLD in coronary artery disease

Miao, Zong; Garske, Kristina M.; Pan, David Z.; Koka, Amogha; Kaminska, Dorota; Männistö, Ville; Sinsheimer, Janet S.; Pihlajamäki, Jussi; Pajukanta, Päivi. 2022. HGG advances. 3:

Immigrants’ perspectives on healthy life and healthy lifestyle counseling: a focus group study

Nekouei Marvi Langari, Maliheh; Lindström, Jaana; Absetz, Pilvikki; Laatikainen, Tiina; Pihlajamäki, Jussi; Tilles-Tirkkonen, Tanja; Turunen, Hannele. 2022. Scandinavian journal of public health. [Epub ahead of 8 February 2022]: 1-10

Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease

Sehgal, Ratika; de Mello, Vanessa D.; Männistö, Ville; Lindström, Jaana; Tuomilehto, Jaakko; Pihlajamäki, Jussi; Uusitupa, Matti. 2022. Nutrients. 14:

PSD3 downregulation confers protection against fatty liver disease

Mancina, Rosellina M; Sasidharan, Kavitha; Lindblom, Anna; Wei, Ying; Ciociola, Ester; Jamialahmadi, Oveis; Pingitore, Piero; Andréasson, Anne-Christine; Pellegrini, Giovanni; Baselli, Guido; Männistö, Ville; Pihlajamäki, Jussi; Kärjä, Vesa; Grimaudo, Stefania; Marini, Ilaria; Maggioni, Marco; Becattini, Barbara; Tavaglione, Federica; Dix, Carly; Castaldo, Marie; Klein, Stephanie; Perelis, Mark; Pattou, Francois; Thuillier, Dorothée; Raverdy, Violeta; Dongiovanni, Paola; Fracanzani, Anna Ludovic. 2022. Nature metabolism. 4: 60-75

Rare ATG7 genetic variants predispose patients to severe fatty liver disease

Baselli, Guido A.; Jamialahmadi, Oveis; Pelusi, Serena; Ciociola, Ester; Malvestiti, Francesco; Saracino, Marco; Santoro, Luigi; Cherubini, Alessandro; Dongiovanni, Paola; Maggioni, Marco; Bianco, Cristiana; Tavaglione, Federica; Cespiati, Annalisa; Mancina, Rosellina M.; D’Ambrosio, Roberta; Vaira, Valentina; Petta, Salvatore; Miele, Luca; Vespasiani-Gentilucci, Umberto; Federico, Alessandro; Pihlajamaki, Jussi; Bugianesi, Elisabetta; Fracanzani, Anna L.; Reeves, Helen L.; Soardo, Giorgio; Prat. 2022. Journal of hepatology. 77: 596-606

Real-world effectiveness of digital and group-based lifestyle interventions as compared with usual care to reduce type 2 diabetes risk – A stop diabetes pragmatic randomised trial

Lakka, Timo A.; Aittola, Kirsikka; Järvelä-Reijonen, Elina; Tilles-Tirkkonen, Tanja; Männikkö, Reija; Lintu, Niina; Karhunen, Leila; Kolehmainen, Marjukka; Harjumaa, Marja; Mattila, Elina; Järvenpää, Riia; Ermes, Miikka; Mikkonen, Santtu; Martikainen, Janne; Poutanen, Kaisa; Schwab, Ursula; Absetz, Pilvikki; Lindström, Jaana; Pihlajamäki, Jussi. 2022. The Lancet regional health – Europe. 2023; 24:

Sensory Appeal and Routines Beat Health Messages and Visibility Enhancements: Mixed-Methods Analysis of a Choice-Architecture Intervention in a Workplace Cafeteria

Rantala, Eeva; Järvelä-Reijonen, Elina; Pettersson, Kati; Laine, Janne; Vartiainen, Paula; Närväinen, Johanna; Pihlajamäki, Jussi; Poutanen, Kaisa; Absetz, Pilvikki; Karhunen, Leila. 2022. Nutrients. 14:

The FADS1 genotypes modify the effect of linoleic acid-enriched diet on adipose tissue inflammation via pro-inflammatory eicosanoid metabolism

Vaittinen, Maija; Lankinen, Maria A; Käkelä, Pirjo; Ågren, Jyrki; Wheelock, Craig E; Laakso, Markku; Schwab, Ursula; Pihlajamäki, Jussi. 2022. European journal of nutrition. 61: 3707-3718

The FADS1 rs174550 Genotype Modifies the n‐3 and n‐6 PUFA and Lipid Mediator Responses to a High Alpha‐Linolenic Acid and High Linoleic Acid Diets

Meuronen, Topi; Lankinen, Maria A; Kolmert, Johan; Laaksonen, Vanessa de Mello; Sallinen, Taisa; Ågren, Jyrki; Virtanen, Kirsi A; Laakso, Markku; Wheelock, Craig E; Pihlajamäki, Jussi; Schwab, Ursula. 2022. Molecular nutrition and food research. 66:

Choice Architecture Cueing to Healthier Dietary Choices and Physical Activity at the Workplace: Implementation and Feasibility Evaluation

Rantala, Eeva; Vanhatalo, Saara; Tilles-Tirkkonen, Tanja; Kanerva, Markus; Hansen, Pelle Guldborg; Kolehmainen, Marjukka; Männikkö, Reija; Lindström, Jaana; Pihlajamäki, Jussi; Poutanen, Kaisa; Karhunen, Leila; Absetz, Pilvikki. 2021. Nutrients. 13: 3592

Comparison of Communication Channels for Large-Scale Type 2 Diabetes Risk Screening and Intervention Recruitment: Empirical Study

Jalkanen, Kari; Järvenpää, Riia; Tilles-Tirkkonen, Tanja; Martikainen, Janne; Aarnio, Emma; Männikkö, Reija; Rantala, Eeva; Karhunen, Leila; Kolehmainen, Marjukka; Harjumaa, Marja; Poutanen, Kaisa; Ermes, Miikka; Absetz, Pilvikki; Schwab, Ursula; Lakka, Timo; Pihlajamäki, Jussi; Lindström, Jaana; The StopDia Study Group. 2021. JMIR diabetes. 6: e21356

Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery

van der Kolk, Birgitta; Muniandy, Maheswary; Kaminska, Dorota; Alvarez, Marcus; Ko, Arthur; Miao, Zong; Valsesia, Armand; Langin, Dominique; Vaittinen, Maija; Pääkkönen, Mirva; Jokinen, Riikka; Kaye, Sanna; Heinonen, Sini; Virtanen, Kirsi A; Andersson, Daniel; Männistö, Ville; Saris, Wim; Astrup, Arne; Rydén, Mikael; Blaak, Ellen; Pajukanta, Päivi; Pihlajamäki, Jussi; Pietiläinen, Kirsi H. 2021. Journal of clinical endocrinology and metabolism. 106: 1312-1324

Digitalization as an Engine for Change? Building a Vision Pathway towards a Sustainable Health Care System by Using the MLP and Health Economic Decision Modelling

Leväsluoto, Johanna; Kohl, Johanna; Sigfrids, Anton; Pihlajamäki, Jussi; Martikainen, Janne. 2021. Sustainability. 13: 13007

Endothelial function and concentrations of high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha during a long agonist IVF protocol

Leppänen, Jonna; Randell, Kaisa; Schwab, Ursula; Pihlajamäki, Jussi; Romppanen, Jarkko; Keski-Nisula, Leea; Heinonen, Seppo; Laitinen, Tomi. 2021. Journal of reproductive immunology. 148: 103434

Enhanced Eating Competence Is Associated with Improved Diet Quality and Cardiometabolic Profile in Finnish Adults with Increased Risk of Type 2 Diabetes

Aittola, Kirsikka; Karhunen, Leila; Männikkö, Reija; Järvelä-Reijonen, Elina; Mikkonen, Santtu; Absetz, Pilvikki; Kolehmainen, Marjukka; Schwab, Ursula; Harjumaa, Marja; Lindström, Jaana; Lakka, Timo; Tilles-Tirkkonen, Tanja; Pihlajamäki, Jussi. 2021. Nutrients. 13: 4030

Exome-wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated with Fatty Liver Disease

Jamialahmadi, Oveis; Mancina, Rosellina Margherita; Ciociola, Ester; Tavaglione, Federica; Luukkonen, Panu K; Baselli, Guido; Malvestiti, Francesco; Thuillier, Dorothée; Raverdy, Violeta; Männistö, Ville; Pipitone, Rosaria Maria; Pennisi, Grazia; Prati, Daniele; Spagnuolo, Rocco; Petta, Salvatore; Pihlajamäki, Jussi; Pattou, François; Yki-Järvinen, Hannele; Valenti, Luca; Romeo, Stefano. 2021. Gastroenterology. 160: 1634-1646

FADS1 rs174550 genotype and high linoleic acid diet modify plasma PUFA phospholipids in a dietary intervention study

Meuronen, Topi; Lankinen, Maria A.; Kärkkäinen, Olli; Laakso, Markku; Pihlajamäki, Jussi; Hanhineva, Kati; Schwab, Ursula. 2021. European journal of nutrition. 2022; 61: 1109-1120

Formation and Validation of the Healthy Diet Index (HDI) for Evaluation of Diet Quality in Healthcare

Lindström, Jaana; Aittola, Kirsikka; Pölönen, Auli; Hemiö, Katri; Ahonen, Kirsti; Karhunen, Leila; Männikkö, Reija; Siljamäki-Ojansuu, Ulla; Tilles-Tirkkonen, Tanja; Virtanen, Eeva; Pihlajamäki, Jussi; Schwab, Ursula. 2021. International journal of environmental research and public health. 18: 2362

Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

Pan, David Z; Miao, Zong; Comenho, Caroline; Rajkumar, Sandhya; Koka, Amogha; Lee, Seung Hyuk T; Alvarez, Marcus; Kaminska, Dorota; Ko, Arthur; Sinsheimer, Janet S; Mohlke, Karen L; Mancuso, Nicholas; Muñoz-Hernandez, Linda Liliana; Herrera-Hernandez, Miguel; Tusié-Luna, Maria Teresa; Aguilar-Salinas, Carlos; Pietiläinen, Kirsi H; Pihlajamäki, Jussi; Laakso, Markku; Garske, Kristina M; et al.. 2021. Genome medicine. 13: 123

Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis

Sehgal, Ratika Ilha, Mariana Vaittinen, Maija Kaminska, Dorota Männistö, Ville Kärjä, Vesa Tuomainen, Marjo Hanhineva, Kati Romeo, Stefano Pajukanta, Päivi Pihlajamäki, Jussi de Mello, Vanessa D.. 2021. Nutrients. 13: 3509

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

Selvarajan, Ilakya; Toropainen, Anu; Garske, Kristina M.; López Rodríguez, Maykel; Ko, Arthur; Miao, Zong; Kaminska, Dorota; Õunap, Kadri; Örd, Tiit; Ravindran, Aarthi; Liu, Oscar H.; Moreau, Pierre R.; Jawahar Deen, Ashik; Männistö, Ville; Pan, Calvin; Levonen, Anna-Liisa; Lusis, Aldons J.; Heikkinen, Sami; Romanoski, Casey E.; Pihlajamäki, Jussi; Pajukanta, Päivi; Kaikkonen, Minna U.. 2021. American journal of human genetics. 108: 411-430

NR1H4 rs35724 G>C Variant Modulates Liver Damage in Nonalcoholic Fatty Liver Disease

Grimaudo, S; Dongiovanni, P; Pihlajamäki, J; Eslam, M; Yki-Järvinen, H; Pipitone, RM; Baselli, G; Cammà, C; Di Marco, V; Enea, M; Longo, M; Pennisi, G; Prati, D; Zito, R; Fracanzani, AL; Craxì, A; George, J; Romeo, S; Valenti, L; Petta, S. 2021. Liver international. 41: 2712-2719

Oxygen-18 and Carbon-13 isotopes in eCO 2 and erythrocytes carbonic anhydrase activity of Finnish prediabetic population

Kårlund, Anna; Kääriäinen, Teemu; Kostamo, Vili M; Kokkola, Tarja; Kolehmainen, Marjukka; Lakka, Timo A; Pihlajamäki, Jussi; Manninen, Albert. 2021. Journal of breath research. 15: 21001

Sleep-time physiological recovery is associated with eating habits in distressed working-age Finns with overweight: secondary analysis of a randomised controlled trial

Järvelä-Reijonen, Elina; Järvinen, Suvi; Karhunen, Leila; Föhr, Tiina; Myllymäki, Tero; Sairanen, Essi; Lindroos, Sanni; Peuhkuri, Katri; Hallikainen, Maarit; Pihlajamäki, Jussi; Puttonen, Sampsa; Korpela, Riitta; Ermes, Miikka; Lappalainen, Raimo; Kujala, Urho M; Kolehmainen, Marjukka; Laitinen, Jaana. 2021. Journal of occupational medicine and toxicology. 16: 23

The FADS1 Genotype Modifes Metabolic Responses to the Linoleic Acid and Alpha-linolenic Acid Containing Plant Oils-Genotype Based Randomized Trial FADSDIET2

Lankinen, MA; de Mello, VD; Meuronen, T; Sallinen, T; Ågren, J; Virtanen, KA; Laakso, M; Pihlajamäki, J; Schwab, U. 2021. Molecular nutrition and food research. 65: 2001004

Change in abdominal, but not femoral subcutaneous fat CT-radiodensity is associated with improved metabolic profile after bariatric surgery

Dadson, Prince; Rebelos, Eleni; Honka, Henri; Juárez-Orozco, Luis E; Kalliokoski, Kari K; Iozzo, Patricia; Teuho, Jarmo; Salminen, Paulina; Pihlajamäki, Jussi; Hannukainen, Jarna C; Nuutila, Pirjo. 2020. Nutrition metabolism and cardiovascular diseases. 30: P2363-2371

Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques

Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, Heikki; Hiltunen, Mikko]. 2020. Molecular neurodegeneration. 15: 66

Dietary fiber from oat and rye brans ameliorate Western diet-induced body weight gain and hepatic inflammation by the modulation of short chain fatty acids, bile acids, and tryptophan metabolism

Kundi, Zuzanna Maria; Lee, Jetty Chung-Yung; Pihlajamäki, Jussi; Chan, Chi Bun; Leung, Kin Sum; So, Stephanie Sik Yu; Nordlund, Emilia; Kolehmainen, Marjukka; El-Nezami, Hani. 2020. Molecular nutrition and food research. 2021; 65: 1900580

Effect of metabolic state on implicit and explicit responses to food in young healthy females

Juvonen, K; Lapveteläinen, A; Närväinen, J; Absetz, P; Kantanen, T; Kolehmainen, M; Sinikallio, S; Pihlajamäki, J; Karhunen, L. 2020. Appetite. 148: 104593

Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes

García-Calzón, Sonia; Perfilyev, Alexander; Martinell, Mats; Ustinova, Monta; Kalamajski, Sebastian; Franks, Paul W; Bacos, Karl; Elbere, Ilze; Pihlajamäki, Jussi; Volkov, Petr; Vaag, Allan; Groop, Leif; Maziarz, Marlena; Klovins, Janis; Ahlqvist, Emma; Ling, Charlotte. 2020. Science translational medicine. 12: eaaz1803

Genetic variants in the MTHFR are not associated with fatty liver disease.

De Vincentis, Antonio; Mancina, Rosellina Margherita; Pihlamajäki, Jussi; Männistö, Ville; Petta, Salvatore; Dongiovanni, Paola; Fracanzani, Anna; Valenti, Luca; Tavaglione, Federica; Romeo, Stefano; Vespasiani-Gentilucci, Umberto. 2020. Liver international. 40: 1934-1940

Internet-Based Lifestyle Intervention to Prevent Type 2 Diabetes Through Healthy Habits: Design and 6-Month Usage Results of Randomized Controlled Trial

Harjumaa, Marja; Absetz, Pilvikki; Ermes, Miikka; Mattila, Elina; Männikkö, Reija; Tilles-Tirkkonen, Tanja; Lintu, Niina; Schwab, Ursula; Umer, Adil; Leppänen, Juha; Pihlajamäki, Jussi. 2020. JMIR diabetes. 5: e15219

LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover

Tanaka, Yuki; Shimanaka, Yuta; Caddeo, Andrea; Kubo, Takuya; Mao, Yanli; Kubota, Tetsuya; Kubota, Naoto; Yamauchi, Toshimasa; Mancina, Rosellina Margherita; Baselli, Guido; Luukkonen, Panu; Pihlajamäki, Jussi; Yki-Järvinen, Hannele; Valenti, Luca; Arai, Hiroyuki; Romeo, Stefano; Kono, Nozomu. 2020. Gut. 2021; 70: 180-193

Miten tyypin 2 diabeteksen ehkäisy pitäisi järjestää?

Pihlajamäki, Jussi; Lindström, Jaana. 2020. Duodecim. 136: 477-478

Mucosal-associated invariant T cell alterations during the development of human type 1 diabetes

Gazali, Ahmad M; Schroderus, Anna-Mari; Näntö-Salonen, Kirsti; Rintamäki, Reeta; Pihlajamäki, Jussi; Knip, Mikael; Veijola, Riitta; Toppari, Jorma; Ilonen, Jorma; Kinnunen, Tuure. 2020. Diabetologia. 63: 2396-2409

PCSK9 rs11591147 R46L loss-of-function variant protects against liver damage in individuals with NAFLD

Grimaudo, Stefania; Bartesaghi, Stefano; Rametta, Raffaela; Marra, Fabio; Margherita Mancina, Rosellina; Pihlajamäki, Jussi; Kakol-Palm, Dorota; Andreasson, Anne-Christine; Dongiovanni, Paola; Ludovica Fracanzani, Anna; Lori, Giulia; Männistö, Ville; Pellegrini, Giovanni; Bohlooly-Y, Mohammad; Pennisi, Grazia; Maria Pipitone, Rosaria; Spagnuolo, Rocco; Craxi, Antonio; Linden, Daniel; Valenti, Luca; et al.. 2020. Liver international. 2021; 41: 321-332

Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice

De Jesus, Dario; Orime, Kazuki; Kaminska, Dorota; Kimura, Tomohiko; Basile, Giorgio; Wang, Chih-Hao; Haertle, Larissa; Riemens, Renzo; Brown, Natalie; Hu, Jiang; Männistö, Ville; Silva, Amélia; Dirice, Ercument; Tseng, Yu-Hua; Haaf, Thomas; Pihlajamäki, Jussi; Kulkarni, Rohit. 2020. Journal of clinical investigation. 130: 2391-2407

Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition

Männistö, Ville; Kaminska, Dorota; Käkelä, Pirjo; Neuvonen, Mikko; Niemi, Mikko; Alvarez, Marcus; Pajukanta, Päivi; Romeo, Stefano; Nieuwdorp, Max; Groen, Albert K; Pihlajamäki, Jussi. 2020. Hepatology communications. 2021; 5: 244-257

Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids

de Mello, Vanessa D; Sehgal, Ratika; Männistö, Ville; Klåvus, Anton; Nilsson, Emma; Perfilyev, Alexander; Kaminska, Dorota; Miao, Zong; Pajukanta, Päivi; Ling, Charlotte; Hanhineva, Kati; Pihlajamäki, Jussi. 2020. Liver international. 2021; 41: 754-763

StopDia-hankkeesta vinkkejä terveyden edistämiseen ja hyte-johtamiseen

Tilles-Tirkkonen, Tanja; Männikkö, Reija; Lindström, Jaana; Harjumaa, Marja; Aittola, Kirsikka; Järvelä-Reijonen, Elina; Rantala, Eeva; Martikainen, Janne; Lakka, Timo; Pihlajamäki, Jussi. 2020. Ravitsemusasiantuntija. 6: 4-7

StopDian opetukset: viesti vahvasti ja tee osallistuminen helpoksi

Lindström, Jaana; Harjumaa, Marja; Pihlajamäki, Jussi. 2020. DIABETES JA LÄÄKÄRI. 49: 9-14

The Effects of Acceptance and Commitment Therapy (ACT) Intervention on Inflammation and Stress Biomarkers: a Randomized Controlled Trial

Järvelä-Reijonen, Elina; Puttonen, Sampsa; Karhunen, Leila; Sairanen, Essi; Laitinen, Jaana; Kolehmainen, Mikko; Pihlajamäki, Jussi; Kujala, Urho M; Korpela, Riitta; Ermes, Miikka; Lappalainen, Raimo; Kolehmainen, Marjukka. 2020. International journal of behavioral medicine. 27: 539-555

The effect of different estradiol levels on carotid artery distensibility during a long agonist IVF protocol

Leppänen, Jonna; Randell, Kaisa; Schwab, Ursula; Pihlajamäki, Jussi; Keski-Nisula, Leea; Laitinen, Tomi; Heinonen, Seppo. 2020. Reproductive biology and endocrinology. 18: 44

An Isocaloric Nordic Diet Modulates RELA and TNFRSF1A Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome-A SYSDIET Sub-Study

Ulven, SM; Holven, KB; Rundblad, A; Myhrstad, MCW; Leder, L; Dahlman, I; Mello, VD; Schwab, U; Carlberg, C; Pihlajamäki, J; Hermansen, K; Dragsted, LO; Gunnarsdottir, I; Cloetens, L; Åkesson, B; Rosqvist, F; Hukkanen, J; Herzig, KH; Savolainen, MJ; Risérus, U; et al. [incl. Uusitupa, M]. 2019. Nutrients. 11: 2932

Association of fatty liver disease with mortality outcomes in an Eastern Finland male cohort

Olubamwo, Olubunmi O; Virtanen, Jyrki K; Pihlajamäki, Jussi; Tuomainen, Tomi-Pekka. 2019. BMJ open gastroenterology. 6: e000219

Association of fatty liver index with risk of incident type 2 diabetes by metabolic syndrome status in an Eastern Finland male cohort: a prospective study

Olubamwo, OO; Virtanen, JK; Pihlajamaki, J; Tuomainen, TP. 2019. BMJ open. 9: e026949

Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study

Keski-Rahkonen, Pekka; Kolehmainen, Marjukka; Lappi, Jenni; Micard, Valerie; Jokkala, Jenna; Rosa-Sibakov, Natalia; Pihlajamäki, Jussi; Kirjavainen, Pirkka V; Mykkänen, Hannu; Poutanen, Kaisa; Gunter, Marc J; Scalbert, Augustin; Hanhineva, Kati. 2019. American journal of clinical nutrition. 109: 1630-1639

Digitally supported program for type 2 diabetes risk identification and risk reduction in real-world setting: protocol for the StopDia model and randomized controlled trial

Pihlajamäki, J; Männikkö, R; Tilles-Tirkkonen, T; Karhunen, L; Kolehmainen, M; Schwab, U; Lintu, N; Paananen, J; Järvenpää, R; Harjumaa, M; Martikainen, J; Kohl, J; Poutanen, K; Ermes, M; Absetz, P; Lindström, J; Lakka, TA. 2019. Bmc public health. 19: 255

Eating Competence Is Associated with Lower Prevalence of Obesity and Better Insulin Sensitivity in Finnish Adults with Increased Risk for Type 2 Diabetes: The StopDia Study

Tilles-Tirkkonen, Tanja; Aittola, Kirsikka; Männikkö, Reija; Absetz, Pilvikki; Kolehmainen, Marjukka; Schwab, Ursula; Lindström, Jaana; Lakka, Timo; Pihlajamäki, Jussi; Karhunen, Leila. 2019. Nutrients. 2020; 12: 104

Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study

Cardona, A; Day, FR; Perry, JRB; Loh, M; Chu, AY; Lehne, B; Paul, DS; Lotta, LA; Stewart, ID; Kerrison, ND; Scott, RA; Khaw, KT; Forouhi, NG; Langenberg, C; Liu, C; Mendelson, MM; Levy, D; Beck, S; Leslie, RD; Dupuis, J; et al. [incl. Pihlajamäki, J]. 2019. Diabetes. 68: 2315-2326

Fatty liver index as a predictor of increased risk of cardiometabolic disease: finding from the Kuopio Ischaemic Heart Disease Risk Factor Study Cohort

Olubamwo OO, Virtanen JK, Pihlajamaki J, Mantyselka P, Tuomainen TP. 2019. BMJ open. 9: e031420

Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with the Metabolic Syndrome - A SYSDIET Sub-Study

Myhrstad, MC; de Mello, VD; Dahlman, I; Kolehmainen, M; Paananen, J; Rundblad, A; Carlberg, C; Olstad, OK; Pihlajamäki, J; Holven, KB; Hermansen, K; Dragsted, LO; Gunnarsdottir, I; Cloetens, L; Storm, MU; Åkesson, B; Rosqvist, F; Hukkanen, J; et al. (incl. Schwab, U; Uusitupa, M). 2019. Molecular nutrition and food research. 63: 1801405

Hyvinvoinnin ja osallisuuden edistäminen vaatii uusia vaikuttavia keinoja

Mäki-Opas, Tomi; Tilles-Tirkkonen, Tanja; Saari, Eveliina; Järvenpää, Riia; Lindström, Jaan; Karhunen, Leila; Kurki, Marjo; Pihlajamäki, Jussi; Niemi, Anna-Maija; Laaksonen, Linda Maria; Korkiakangas, Eveliina; Lakka, Timo; Vaarama, Marja; Laitinen, Jaana. 2019. Policy Brief / SA. : 1-12

Inflammatory response to dietary linoleic acid depends on FADS1 genotype

Lankinen, MA; Fauland, A; Shimizu, BI; Ågren, J; Wheelock, CE; Laakso, M; Schwab, U; Pihlajamäki, J. 2019. American journal of clinical nutrition. 109: 165-175

Laparoscopic Roux-en-Y gastric bypass surgery influenced pharmacokinetics of several drugs given as a cocktail with the highest impact observed for CYP1A2, CYP2C8 and CYP2E1 substrates

Puris, E; Pasanen, M; Ranta, VP; Gynther, M; Petsalo, A; Käkelä, P; Männistö, V; Pihlajamäki, J. 2019. Basic and clinical pharmacology and toxicology. 125: 123-132

Liver DNA methylation of FADS2 associates with FADS2 genotypex

Walle, P; Männistö, V; de Mello, VD; Vaittinen, M; Perfilyev, A; Hanhineva, K; Ling, C; Pihlajamäki, J. 2019. Clinical epigenetics. 11: 10

Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation-Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl-Coenzyme A Desaturase As an Enhancer RNA

Benhammou, Jihane N; Ko, Arthur; Alvarez, Marcus; Kaikkonen, Minna U; Rankin, Carl; Garske, Kristina M; Padua, David; Bhagat, Yash; Kaminska, Dorota; Karja, Vesa; Pihlajamäki, Jussi; Pisegna, Joseph R; Pajukanta, Päivi. 2019. Hepatology communications. 3: 1356-1372

PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients

Dongiovanni, P; Meroni, M; Baselli, GA; Mancina, RM; Ruscica, M; Longo, M; Rametta, R; Cespiati, A; Pelusi, S; Ferri, N; Ranzani, V; Nobili, V; Pihlajamaki, J; Fracanzani, AL; Badiali, S; Petta, S; Fargion, S; Romeo, S; Kozlitina, J; Valenti, L. 2019. Journal of lipid research. 60: 1144-1153

Prevalence and Risk Factors if Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Without Steatohepatitis

Pelusi, S; Cespiati, A; Rametta, R; Pennisi, G; Mannisto, V; Rosso, C; Baselli, G; Dongiovanni, P; Fracanzani, AL; Badiali, S; Maggioni, M; Craxi, A; Fargion, S; Prati, D; Nobili, V; Bugianesi, E; Romeo, S; Pihlajamaki, J; Petta, S; Valenti, L. 2019. Clinical gastroenterology and hepatology. 17: 2310-2319.e6

Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression

Männistö, V; Kaminska, D; Kärjä, V; Tiainen, M; de Mello, VD; Hanhineva, K; Soininen, P; Ala-Korpela, M; Pihlajamäki, J. 2019. Liver international. 39: 1895-1905

Association of fatty liver index with the risk of incident cardiovascular disease and acute myocardial infarction.

Olubamwo, Olubamwo O; Virtanen, Jyrki K; Voutilainen, Ari; Kauhanen, Jussi; Pihlajamäki, Jussi; Tuomainen, Tomi-Pekka. 2018. European journal of gastroenterology and hepatology. 30: 1047-1054

Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals

Tuomainen, Marjo; Lindström, Jaana; Lehtonen, Marko; Auriola, Seppo; Pihlajamäki, Jussi; Peltonen, Markku; Tuomilehto, Jaakko; Uusitupa, Matti; de Mello, Vanessa D; Hanhineva, Kati. 2018. Nutrition and diabetes. 8: 35

Brown adipose tissue lipid metabolism in morbid obesity : effect of bariatric surgery-induced weight loss

Dadson, Prince; Hannukainen, Jarna C; Din, Mueez U; Lahesmaa, Minna; Kalliokoski, Kari K; Iozzo, Patricia; Pihlajamäki, Jussi; Karlsson, Henry K; Parkkola, Riitta; Salminen, Paulina; Virtanen, Kirsi A; Nuutila, Pirjo. 2018. Diabetes obesity and metabolism. 20: 1280-1288

Effector T Cell Resistance to Suppression and STAT3 Signaling during the Development of Human Type 1 Diabetes

Ihantola, EL; Viisanen, T; Gazali, AM; Näntö-Salonen, K; Juutilainen, A; Moilanen, L; Rintamäki, R; Pihlajamäki, J; Veijola, R; Toppari, J; Knip, M; Ilonen, J; Kinnunen, T. 2018. Journal of immunology. 201: 1144-1153

Evaluation of the effect of bariatric surgery-induced weight loss on knee gait and cartilage degeneration

Liukkonen, MK; Mononen, ME; Vartiainen, P; Kaukinen, P; Bragge, T; Suomalainen, JS; Malo, MKH; Venesmaa, S; Käkelä, P; Pihlajamäki, J; Karjalainen, PA; Arokoski, JP; Korhonen, R. 2018. Journal of biomechanical engineering: transactions of the ASME. 14: 41008

Incidence, comorbidities, and mortality in idiopathic normal pressure hydrocephalus

Pyykkö, OT; Nerg, O; Niskasaari, HM; Niskasaari, T; Koivisto, AM; Hiltunen, M; Pihlajamäki, J; Rauramaa, T; Kojoukhova, M; Alafuzoff, I; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2018. World neurosurgery. 112: e624-e631

Kirjasto- ja tietopalvelut on turvattava

Saarti, Jarmo; Pihlajamäki, Jussi; Vanninen, Esko. 2018. Lääkärilehti. 73: 117

Measured energy content of frequently purchased restaurant meals: multi-country cross sectional study

Roberts, SB; Das, SK; Suen, VMM; Pihlajamäki, J; Kuriyan, R; Steiner-Asiedu, M; Taetzsch, A; Anderson, AK; Silver, RE; Barger, K; Krauss, A; Karhunen, L; Zhang, X; Hambly, C; Schwab, U; Triffoni-Melo, AT; Taylor, SF; Economos, C; Kurpad, AV; Speakman, JR. 2018. BMJ. 363: k4864

Protein Phosphatase 1 Regulatory Subunit 3B Gene Variation Protects Against Hepatic Fat Accumulation and Fibrosis in Individuals at High Risk of Nonalcoholic Fatty Liver Disease

Dongiovanni, Paola; Meroni, Marica; Mancina, Rosellina M; Baselli, Guido; Rametta, Raffaela; Pelusi, Serena; Männisto, Ville; Fracanzani, Anna L; Badiali, Sara; Miele, Luca; Grimaudo, Stefania; Petta, Salvatore; Bugianesi, Elisabetta; Soardo, Giorgio; Fargion, Silvia; Pihlajamäki, Jussi; Romeo, Stefano; Valenti, Luca. 2018. Hepatology communications. 2: 666-675

Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD

Tauriainen, Milla-Maria; Männistö, Ville; Kaminska, Dorota; Vaittinen, Maija; Kärjä, Vesa; Käkelä, Pirjo; Venesmaa, Sari; Gylling, Helena; Pihlajamäki, Jussi. 2018. Bioscience reports. 38: 1-9

Sex Differences in the Methylome and Transcriptome of the Human Liver and Circulating HDL-Cholesterol Levels

García-Calzón, Sonia; Perfilyev, Alexander; de Mello, Vanessa D; Pihlajamäki, Jussi; Ling, Charlotte. 2018. Journal of clinical endocrinology and metabolism. 103: 4395-4408

Small Intestinal Length Associates with Serum Triglycerides Before and After LRYGB

Käkelä, Pirjo; Männistö, Ville; Vaittinen, Maija; Venesmaa, Sari; Kärjä, Vesa; Virtanen, Kirsi; Paajanen, Hannu; Pihlajamäki, Jussi. 2018. Obesity surgery. 28: 3969-3975

Sosioekonomisesti heikommassa asemassa olevien kiinnostus ja mahdollisuudet digitaalisten terveyspalveluiden käyttöön

Tilles-Tirkkonen, Tanja; Lappi, Jenni; Karhunen, Leila; Harjumaa, Marja; Absetz, Pilvikki; Pihlajamäki, Jussi. 2018. Yhteiskuntapolitiikka. 83: 317-323

The effects of acceptance and commitment therapy on eating behavior and diet delivered through face-to-face contact and a mobile app: a randomized controlled trial

Järvelä-Reijonen, Elina; Karhunen, Leila; Sairanen, Essi; Muotka, Joona; Lindroos, Sanni; Laitinen, Jaana; Puttonen, Sampsa; Peuhkuri, Katri; Hallikainen, Maarit; Pihlajamäki, Jussi; Korpela, Riitta; Ermes, Miikka; Lappalainen, Raimo; Kolehmainen, Marjukka. 2018. International journal of behavioral nutrition and physical activity. 15: 22

Uudet toimintamallit hyvinvoinnin ja terveyden edistämisessä

Tilles-Tirkkonen, Tanja; Mäki-Opas, Tomi; Vaarama, Marja; Logren, Aija; Pentikäinen, Saara; Tiitinen, Sanni; Ilomäki, Sakari; Pihlajamäki, Jussi; Laitinen, Jaana. 2018. Sosiaalilääketieteellinen aikakauslehti. 55: 364-369

Alterations in fatty acid metabolism in response to obesity surgery combined with dietary counseling

Walle P, Takkunen M, Männistö V, Vaittinen M, Käkelä P, Ågren J, Schwab U, Lindström J, Tuomilehto J, Uusitupa M, Pihlajamäki J. 2017. Nutrition and diabetes. 7: e285

Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver

Dongiovanni P, Stender S, Pietrelli A, Mancina RM, Cespiati A, Petta S, Pelusi S, Pingitore P, Badiali S, Maggioni M, Mannisto V, Grimaudo S, Pipitone RM, Pihlajamaki J, Craxi A, Taube M, Carlsson LMS, Fargion S, Romeo S, Kozlitina J et al.. 2017. Journal of internal medicine. 2018; 283: 356-370

Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodi

Viisanen T, Ihantola E-L, Näntö-Salonen K, Hyöty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamäki J, Veijola R,Toppari J, Knip M, Ilonen J, Kinnunen T. 2017. Diabetes. 66: 437-447

Comprehensive pharmacogenomic study reveals an important role of UGT1A3 in montelukast pharmacokinetics

Hirvensalo, P; Tornio, A; Neuvonen, M; Tapaninen, T; Paile-Hyvärinen, M; Kärjä, V; Männistö, VT; Pihlajamäki, J; Backman, JT; Niemi, M. 2017. Clinical pharmacology and therapeutics. 2018; 104: 158-168

Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver

García-Calzón Sonia, Perfilyev Alexander, Männistö Ville, de Mello Vanessa D, Nilsson Emma, Pihlajamäki Jussi, Ling Charlotte. 2017. Clinical epigenetics. 9: 102

Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects

Neuvonen M, Tarkiainen EK, Tornio A, Hirvensalo P, Tapaninen T, Paile-Hyvärinen M, Itkonen MK, Holmberg MT, Kärjä V, Männistö VT, Neuvonen PJ, Pihlajamäki J, Backman JT, Niemi M. 2017. Basic and clinical pharmacology and toxicology. 2018; 122: 341-345

Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes

de Mello VD, Lankinen MA, Lindström J, Puupponen-Pimiä R, Laaksonen DE, Pihlajamäki J, Lehtonen M, Uusitupa M, Tuomilehto J, Kolehmainen M, Törrönen R, Hanhineva K. 2017. Molecular nutrition and food research. 61: 1700019

Fatty acid uptake and blood flow in adipose tissue compartments of morbidly obese subjects with or without type 2 diabetes: Effects of bariatric surgery

Dadson P, Ferrannini E, Landini L, Hannukainen JC, Kalliokoski KK, Vaittinen M, Honka H, Karlsson HK, Tuulari JJ, Soinio M, Salminen P, Parkkola R, Pihlajamäki J, Iozzo P, Nuutila P. 2017. American journal of physiology : endocrinology and metabolism. 313: E175-E182

Hepatic DPP4 DNA Methylation Associates With Fatty Liver

Baumeier Christian, Saussenthaler Sophie, Kammel Anne, Jähnert Markus, Schlüter Luisa, Hesse Deike, Canouil Mickaël, Lobbens Stephane, Caiazzo Robert, Raverdy Violeta, Pattou François, Nilsson Emma, Pihlajamäki Jussi, Ling Charlotte, Froguel Philippe, Schürmann Annette, Schwenk Robert W. 2017. Diabetes. 66: 25 - 35

Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action

de Mello VD, Matte A, Perfilyev A, Männistö V, Rönn T, Nilsson E, Käkelä P, Ling C, Pihlajamäki J. 2017. Epigenetics. [Epub 2017 Feb 23]: 287-295

Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells

López Rodríguez M, Kaminska D, Lappalainen K, Pihlajamäki J, Kaikkonen MU, Laakso M. 2017. Genome medicine. 9: 63

Increased Liver Fatty Acid Uptake Is Partly Reversed and Liver Fat Content Normalized After Bariatric Surgery

Immonen H, Hannukainen JC, Kudomi N, Pihlajamäki J, Saunavaara V, Laine J, Salminen P, Lehtimäki T, Pham T, Iozzo P, Nuutila P. 2017. Diabetes care. 2018; 41: 368-371

Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study

de Mello VD, Paananen J, Lindstrom J, Lankinen MA, Shi L, Kuusisto J, Pihlajamaki J, Auriola S, Lehtonen M, Rolandsson O, Bergdahl IA, Nordin E, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Landberg R, Eriksson JG, Tuomilehto J, Hanhineva K, Uusitupa M. 2017. Scientific reports. 7: 46337

Interorgan cross talk between fatty acid metabolism, tissue inflammation, and FADS2 genotype in humans with obesity

Vaittinen M, Männistö V, Käkelä P, Ågren J, Tiainen M, Schwab U, Pihlajamäki J. 2017. Obesity. 25: 545-552

Molecular evaluation of vitamin D responsiveness of healthy young adults

Seuter Sabine, Virtanen Jyrki K, Nurmi Tarja, Pihlajamäki Jussi, Mursu Jaakko, Voutilainen Sari, Tuomainen Tomi-Pekka, Neme Antonio, Carlberg Carsten. 2017. Journal of steroid biochemistry and molecular biology. 174: 314-321

Obstructive sleep apnea: the effect of bariatric surgery after 12 months. A prospective multicenter trial

Peromaa-Haavisto P, Tuomilehto H, Kössi J, Virtanen J, Luostarinen M, Pihlajamäki J, Käkelä P, Victorzon M. 2017. Sleep medicine. 35: 85-90

A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probe drugs and their corresponding metabolites in human serum and urine

Puris Elena, Pasanen Markku, Gynther Mikko, Häkkinen Merja R, Pihlajamäki Jussi, Keränen Tapani, Honkakoski Paavo, Raunio Hannu, Petsalo Aleksanteri. 2016. Analytical and bioanalytical chemistry. 2017; 409: 251-268

Association of MBOAT7 gene variant with plasma ALT levels in children: The PANIC study

Viitasalo A, Eloranta A-M, Atalay M, Romeo S, Pihlajamäki J, Lakka TA. 2016. Pediatric research. 80: 651-655

Associations of TM6SF2 167K allele with liver enzymes and lipid profile in children: the PANIC Study

Viitasalo Anna, Pihlajamäki Jussi, Paananen Jussi, Atalay Mustafa, Lindi Virpi, Lakka Timo A. 2016. Pediatric research. 79: 684-688

DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk

Dayeh T, Tuomi T, Almgren P, Perfilyev A, Jansson PA, de Mello VD, Pihlajamäki J, Vaag A, Groop L, Nilsson E, Ling C. 2016. Epigenetics. 11: 482-488

Epigenetic alterations in blood mirror age-associated DNA methylation and gene expression changes in human liver

Bysani M, Perfilyev A, de Mello VD, Rönn T, Nilsson E, Pihlajamäki J, Ling C. 2016. Epigenomics. 2017; 9: 105-122

Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity

Walle Paula, Takkunen Markus, Männistö Ville, Vaittinen Maija, Lankinen Maria, Kärjä Vesa, Käkelä Pirjo, Ågren Jyrki, Tiainen Mika, Schwab Ursula, Kuusisto Johanna, Laakso Markku, Pihlajamäki Jussi. 2016. Metabolism: clinical and experimental. 65: 655-666

High perceived stress is associated with unfavorable eating behavior in overweight and obese Finns of working age

Järvelä-Reijonen E, Karhunen L, Sairanen E, Rantala S, Laitinen J, Puttonen S, Peuhkuri K, Hallikainen M, Juvonen K, Myllymäki T, Föhr T, Pihlajamäki J, Korpela R, Ermes M, Lappalainen R, Kolehmainen M. 2016. Appetite. 103: 249-258

Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention

Walenbergh SM, Houben T, Rensen SS, Bieghs V, Hendrikx T, van Gorp PJ, Oligschlaeger Y, Jeurissen ML, Gijbels MJ, Buurman WA, Vreugdenhil AC, Greve JW, Plat J1, Hofker MH, Kalhan S, Pihlajamäki J, Lindsey P, Koek GH, Shiri-Sverdlov R. 2016. Scientific reports. 6: 38278

Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice

Li J, Sung CY, Lee N, Ni Y, Pihlajamäki J, Panagiotou G, El-Nezami H. 2016. Proceedings of the National Academy of Sciences of the United States of America. 113: E1306-E1315

Rasvamaksa - entä sitten?

Männistö Ville, Pihlajamäki JUssi. 2016. Duodecim. 132: 1707-1713

Regulation of alternative splicing in human obesity loci

Kaminska Dorota, Käkelä Pirjo, Nikkola Elina, Venesmaa Sari, Ilves Imre, Herzig Karl-Heinz, Kolehmainen Marjukka, Karhunen Leila, Kuusisto Johanna, Gylling Helena, Pajukanta Päivi, Laakso Markku, Pihlajamäki Jussi. 2016. Obesity. 24: 2033-2037

Serum plant sterols associate with Gallstone disease independent of weight loss and non-alcoholic fatty liver disease

Käkelä P, Männistö V, Ilves I, Vaittinen M, Tauriainen MM, Eskelinen M, Gylling H, Paajanen H, Pihlajamäki J. 2016. Obesity surgery. 27: 1284-1291

Sleep of professional athletes: Underexploited potential to improve health and performance

Tuomilehto Henri, Vuorinen Ville-Pekka, Penttilä Elina, Kivimäki Marko, Vuorenmaa Markus, Venojärvi Mika, Airaksinen Olavi, Pihlajamäki Jussi. 2016. Journal of sports sciences. [epub ahead of print 13 May 2016]: 1-7

Tarvitseeko terve ihminen ravintolisiä?

Schwab U, Pihlajamäki J. 2016. Duodecim. 132: 2329-34

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

Mancina Rosellina Margherita, Dongiovanni Paola, Petta Salvatore, Pingitore Piero, Meroni Marica, Rametta Raffaela, Borén Jan, Montalcini Tizian, Pujia Arturo, Wiklund Olov, Hindy George, Spagnuolo Rocco, Motta Benedetta Maria, Pipitone Rosaria Maria, Craxì Antonio, Fargion Silvia, Nobili Valerio, Käkelä Pirjo, Kärjä Vesa, Männistö Ville et al. 2016. Gastroenterology. 150: 1219-1230

Association of plasma fatty acid composition with plasma irisin levels in normal weight and overweight/obese children

Viitasalo A, Ågren J, Venäläinen T, Pihlajamäki J, Jääskeläinen J, Korkmaz A, Atalay M, Lakka TA. 2015. Pediatric obesity. 2015; 11: 299-305

Cross-linking of sodium caseinate-structured emulsion with transglutaminase alters postprandial metabolic and appetite responses in healthy young individuals

Juvonen Kristiina R, Macierzanka Adam, Lille Martina E, Laaksonen David E, Mykkänen Hannu M, Niskanen Leo K, Pihlajamäki Jussi, Mäkelä Kari A, Mills Clare EN, Mackie Alan R, Malcolm Paul, Herzig Karl-Heinz, Poutanen Kaisa S, Karhunen Leila J. 2015. British journal of nutrition. 114: 418-429

Dietary polyunsaturated fatty acids and the Pro12Ala polymorphisms of PPARG regulate serum lipids through divergent pathways: a randomized crossover clinical trial

Pihlajamäki Jussi, Schwab Ursula, Kaminska Dorota, Ågren Jyrki, Kuusisto Johanna, Kolehmainen Marjukka, Paananen Jussi, Laakso Markku, Uusitupa Matti. 2015. Genes and nutrition. 10: 43

Effect of Bariatric Surgery on Adipose Tissue Glucose Metabolism in Different Depots in Patients With or Without Type 2 Diabetes

Dadson Prince, Landini Linda, Helmiö Mika, Hannukainen Jarna C, Immonen Heidi, Honka Miikka-Juhani, Bucci Marco, Savisto Nina, Soinio Minna, Salminen Paulina, Parkkola Riitta, Pihlajamäki Jussi, Iozzo Patricia, Ferrannini Ele, Nuutila Pirjo. 2015. Diabetes care. 2016; 39: 292-299

Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels

Nilsson Emma, Matte Ashok, Perfilyev Alexander, de Mello Vanessa D, Käkelä Pirjo, Pihlajamäki Jussi, Ling Charlotte. 2015. Journal of clinical endocrinology and metabolism. [epub ahead of p rint Sep 29, 2015]: -

FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue

Vaittinen Maija, Walle Paula, Kuosmanen Emmi, Männistö Ville, Käkelä Pirjo, Ågren Jyrki, Schwab Ursula, Pihlajamäki Jussi. 2015. Journal of lipid research. 2016; 57: 56-65

Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men

Takkunen Markus J, de Mello Vanessa D, Schwab Ursula S, Kuusisto Johanna, Vaittinen Maija, Ågren Jyrki J, Laakso Markku, Pihlajamäki Jussi, Uusitupa MI. 2015. Molecular nutrition and food research. 2016; 60: 381-389

MFAP5 is Related to Obesity-Associated Adipose Tissue and Extracellular Matrix Remodeling and Inflammation

Vaittinen Maija, Kolehmainen Marjukka, Rydén Mikael, Eskelinen Matti, Wabitsch Martin, Pihlajamäki Jussi, Uusitupa Matti, Pulkkinen Leena. 2015. Obesity. 23: 1371-1378

Markers of cholesterol metabolism as biomarkers in predicting diabetes in the Finnish Diabetes Prevention Study

de Mello VDF, Lindström J, Eriksson JG, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Pihlajamäki J, Tuomilehto J, Uusitupa M. 2015. Nutrition metabolism and cardiovascular diseases. 25: 635-642

Persistent organic pollutants and non-alcoholic fatty liver disease in morbidly obese patients: a cohort study

Rantakokko Panu, Männistö Ville, Airaksinen Riikka, Koponen Jani, Viluksela Matti, Kiviranta Hannu, Pihlajamäki Jussi. 2015. Environmental health. 14: 79

Plasma IL-1 receptor antagonist levels correlate with the development of non-alcoholic steatohepatitis

Hendrikx Tim, Walenbergh Sofie MA, Jeurissen Mike LJ, Houben Tom, van Gorp Patrick J, Lindsey Patrick J, Koek Ger H, Kalhan Satish, Pihlajamäki Jussi, Hofker Marten H, Shiri-Sverdlov Ronit. 2015. Biomarkers in medicine. 9: 1301-1309

Plasma fatty acids as predictors of glycaemia and type 2 diabetes

Lankinen Maria A, Stancáková Alena, Uusitupa Matti, Ågren Jyrki, Pihlajamäki Jussi, Kuusisto Johanna, Schwab Ursula, Laakso Markku. 2015. Diabetologia. 58: 2533-2544

Prevalence of Obstructive Sleep Apnoea Among Patients Admitted for Bariatric Surgery: A Prospective Multicentre Trial

Peromaa-Haavisto P, Tuomilehto H, Kössi J, Virtanen J, Luostarinen M, Pihlajamäki J, Käkelä P, Victorzon M. 2015. Obesity surgery. 2016; 26: 1384-1390

Statin use and non-alcoholic steatohepatitis in at risk individuals

Dongiovanni Paola, Petta Salvatore, Mannisto Ville, Mancina Rosellina Margherita, Pipitone Rosaria, Karja Vesa, Maggioni Marco, Kakela Pirjo, Wiklund Olov, Mozzi Enrico, Grimaudo Stefania, Kaminska Dorota, Rametta Raffaela, Craxi Antonio, Fargion Silvia, Nobili Valerio, Romeo Stefano, Pihlajamaki Jussi, Valenti Luca. 2015. Journal of hepatology. 63: 705-712

The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study

Viitasalo Anna, Mustafa Atalay, Pihlajamäki Jussi, Jääskeläinen Jarmo, Korkmaz Ayhan, Kaminska Dorota, Lindi Virpi, Lakka Timo A.. 2015. Metabolism: clinical and experimental. 64: 793-796

Associations of I148M variant in PNPLA3 gene with plasma ALT levels during 2-year follow-up in normal weight and overweight children: the PANIC Study

Viitasalo A, Pihlajamaki J, Lindi V, Atalay M, Kaminska D, Joro R, Lakka TA. 2014. Pediatric obesity. -:

DNA methylation in obesity and type 2 diabetes

de Mello Vanessa Derenji Ferreira, Pulkkinen Leena, Lalli Marianne, Kolehmainen Marjukka, Pihlajamäki Jussi, Uusitupa Matti. 2014. Annals of medicine. 46: 103-113

Effect of bariatric surgery on liver glucose metabolism in morbidly obese diabetic and non-diabetic patients

Immonen H, Hannukainen JC, Iozzo P, Soinio M, Salminen P, Saunavaara V, Borra R, Parkkola R, Mari A, Lehtimäki T, Pham T, Laine J, Kärjä V, Pihlajamäki J, Nelimarkka L, Nuutila P. 2014. Journal of hepatology. 60: 377-383

Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome

Kolehmainen Marjukka, Ulven Stine M, Paananen Jussi, de Mello Vanessa, Schwab Ursula, Carlberg Carsten, Myhrstad Mari, Pihlajamäki Jussi, Dungner Elisabeth, Sjölin Eva, Gunnarsdottir Ingibjörg, Cloetens Lieselotte, Landin-Olsson Mona, Akesson Björn, Rosqvist Fredrik, Hukkanen Janne, Herzig Karl-Heinz, Dragsted Lars O, Savolainen Markku J, Brader Lea, Hermansen Kjeld, Risérus Ulf, Thorsdottir Inga, Poutanen Kaisa S, Uusitupa Matti, Arner Peter, Dahlman Ingrid. 2014. American journal of clinical nutrition. 101: 228-239

High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. Journal of nutritional biochemistry. 25: 634-641

Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans

Männistö Ville T, Simonen Marko, Hyysalo Jenni, Soininen Pasi, Kangas Antti J, Kaminska Dorota, Matte Ananda K, Venesmaa Sari, Käkelä Pirjo, Kärjä Vesa, Arola Johanna, Gylling Helena, Cederberg Henna, Kuusisto Johanna, Laakso Markku, Yki-Järvinen Hannele, Ala-Korpela Mika, Pihlajamäki Jussi. 2014. Liver international. 2015; 35: 1853-1861

Postprandial glucose metabolism and SCFA after consuming wholegrain rye bread and wheat bread enriched with bioprocessed rye bran in individuals with mild gastrointestinal symptoms

Lappi Jenni, Mykkänen Hannu, Bach Knudsen Knud Erik, Kirjavainen Pirkka, Katina Kati, Pihlajamäki Jussi, Poutanen Kaisa, Kolehmainen Marjukka. 2014. Nutrition journal. 13: -

Sairaalapotilaan vajaaravitsemuksen havaitseminen ja hoito

Orell-Kotikangas Helena, Antikainen Anne, Pihlajamäki Jussi. 2014. Duodecim. 130: 2231-8

Specific collagen XVIII isoforms promote adipose tissue accrual via mechanisms determining adipocyte number and affect fat deposition

Aikio Mari, Elamaa Harri, Vicente David, Izzi Valerio, Kaur Inderjeet, Seppinen Lotta, Speedy Helen E, Kaminska Dorota, Kuusisto Sanna, Sormunen Raija, Heijasvaara Ritva, Jones Emma L, Muilu Mikko, Jauhiainen Matti, Pihlajamäki Jussi, Savolainen Markku J, Shoulders Carol C, Pihlajaniemi Taina. 2014. Proceedings of the National Academy of Sciences of the United States of America. 111: E3043-52

The effectiveness and applicability of different lifestyle interventions for enhancing wellbeing: the study design for a randomized controlled trial for persons with metabolic syndrome risk factors and psychological distress

Lappalainen Raimo, Sairanen Essi, Järvelä Elina, Rantala Sanni, Korpela Riitta, Puttonen Sampsa, Kujala Urho M, Myllymäki Tero, Peuhkuri Katri, Mattila Elina, Kaipainen Kirsikka, Ahtinen Aino, Karhunen Leila, Pihlajamäki Jussi, Järnefelt Heli, Laitinen Jaana, Kutinlahti Eija, Saarelma Osmo, Ermes Miikka, Kolehmainen Marjukka. 2014. Bmc public health. 14: -

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

Dongiovanni Paola, Petta Salvatore, Maglio Cristina, Fracanzani Anna Ludovica, Pipitone Rosaria, Mozzi Enrico, Motta Benedetta Maria, Kaminska Dorota, Rametta Raffaela, Grimaudo Stefania, Pelusi Serena, Montalcini Tiziana, Alisi Anna, Maggioni Marco, Kärjä Vesa, Borén Jan, Käkelä Pirjo, Di Marco Vito, Xing Chao, Nobili Valerio et.al.. 2014. Hepatology. Epub ahead of print: -

A population-based study on the prevalence of NASH using scores validated against liver histology

Hyysalo J, Männistö VT, Zhou Y, Arolad J, Kärjä V, Leivonen M, Juut A, Jaser N, Lallukka S, Käkelä P, Venesmaa S, Simonen M, Saltevo J, Moilanen L, Korpi-Hyövalti E, Keinänen-Kiukaanniemi S, Oksa H, Orho-Melander M, Valentik L, Fargionk S, Pihlajamäki J,Peltoneng M, Yki-Järvinena H. 2013. Journal of hepatology. Available online 12 December 2013: -

Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men

Mahendran Y, Vangipurapu J, Cederberg H, Stancáková A, Pihlajamäki J, Soininen P, Kangas AJ, Paananen J, Civelek M, Saleem NK, Pajukanta P, Lusis AJ, Bonnycastle LL, Morken MA, Collins FS, Mohlke KL, Boehnke M, Ala-Korpela M, Kuusisto J, Laakso M. 2013. Diabetes. 62: 3618-3626

Comparative nontargeted profiling of metabolic changes in tissues and biofluids in high-fat diet-fed Ossabaw pig

Hanhineva K, Barri T, Kolehmainen M, Pekkinen J, Pihlajamäki J, Vesterbacka A, Solano-Aguilar G, Mykkänen H, Dragsted LO, Urban JF, Poutanen K. 2013. Journal of proteome research. 12: 3980-3992

Desmosterol in human nonalcoholic steatohepatitis

Simonen M, Männistö V, Leppänen J, Kaminska D, Kärjä V, Venesmaa S, Käkelä P, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. 2013. Hepatology. 58: 976-982

Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes

Vaittinen M, Kaminska D, Käkelä P, Eskelinen M, Kolehmainen M, Pihlajamäki J, Uusitupa M, Pulkkinen L. 2013. Diabetes. 62: 3747-3750

Genetic risk score does not predict the outcome of obesity surgery

Käkelä P, Jääskeläinen T, Torpström J, Ilves I, Venesmaa S, Pääkkönen M, Gylling H, Paajanen H, Uusitupa M, Pihlajamäki J. 2013. Obesity surgery. online: -

Link between GIP and osteopontin in adipose tissue and insulin resistance

Ahlqvist E, Osmark P, Kuulasmaa T, Pilgaard K, Omar B, Brøns C, Kotova O, Zetterqvist AV, Stancáková A, Jonsson A, Hansson O, Kuusisto J, Kieffer TJ, Tuomi T, Isomaa B, Madsbad S, Gomez MF, Poulsen P, Laakso M, Degerman E, et al. (including Pihlajamäki J). 2013. Diabetes. 62: 2088-2094

Mahalaukun ohitus lihavuusleikkauksena: yhden keskuksen kymmenen vuoden kokemukset ja seurannan haasteet

Käkelä P, Torpström J, Venesmaa S, Ilves I, Junnila EL, Penttinen K, Martikainen T, Gylling H, Pääkkönen M, Pihlajamäki J. 2013. Duodecim. 129: 756-764

Non-cholesterol sterol levels predict hyperglycemia and conversion to type 2 diabetes in finnish men

Cederberg H, Gylling H, Miettinen TA, Paananen J, Vangipurapu J, Pihlajamäki J, Kuulasmaa T, Stancáková A, Smith U, Kuusisto J, Laakso M. 2013. PLoS ONE. 8: e67406

Regulation of alternative splicing in obesity and weight loss

Kaminska D, Pihlajamäki J. 2013. Adipocytes. 2: 143-7

Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease

Martiskainen H, Haapasalo A, Kurkinen KM, Pihlajamäki J, Soininen H, Hiltunen M. 2013. Expert opinion on therapeutic targets. 17: 781-794

Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism

Kaminska D, Kuulasmaa T, Venesmaa S, Käkelä P, Vaittinen M, Pulkkinen L, Pääkkönen M, Gylling H, Laakso M, Pihlajamäki J. 2012. Diabetes. 61: 2807-2813

Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass

Simonen M, Dali-Youcef N, Kaminska D, Venesmaa S, Käkelä P, Pääkkönen M, Hallikainen M, Kolehmainen M, Uusitupa M, Moilanen L, Laakso M, Gylling H, Patti ME, Auwerx J, Pihlajamäki J. 2012. Obesity surgery. 22: 1473-1480

Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men

Stancáková Alena, Civelek Mete, Saleem Niyas K, Soininen Pasi, Kangas Antti J, Cederberg Henna, Paananen Jussi, Pihlajamäki Jussi, Bonnycastle Lori L, Morken Mario A, Boehnke Michael, Pajukanta Päivi, Lusis Aldons J, Collins Francis S, Kuusisto Johanna, Ala-Korpela Mika, Laakso Markku. 2012. Diabetes. 61: 1895-1902

Impact of Obesity and Associated Diseases on Outcome After Laparoscopic Cholecystectomy

Paajanen, Hannu; Käkelä, Pirjo; Suuronen, Satu; Paajanen, Juuso; Juvonen, Petri; Pihlajamäki, Jussi. 2012. Surgical laparoscopy endoscopy and percutaneous techniques. 22: 509-513

Lihavuuskirurgian aiheet Suomessa ristiriitaiset

Koivukangas V, Juuti A, Salminen P, Pihlajamäki J. 2012. Lääkärilehti. 67: 1800-1800

Lihavuusleikkauksen jälkeen

Torpström, Jaana; Käkelä, Pirjo; Pihlajamäki, Jussi. 2012. DIABETES JA LÄÄKÄRI. 41: 29-33

Response to Brosch et al.

Pihlajamäki J, Lerin C, Kaminska D, Venesmaa S, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W et.al.. 2012. Cell metabolism. 15: 267-269

Serum interleukin 1 receptor antagonist as anindependent marker of non-alcoholic steatohepatitis in humans

Pihlajamäki J, Kuulasmaa T, Kaminska D, Simonen M, Kärjä V, Grönlund S, Käkelä P, Pääkkönen M, Kainulainen S, Punnonen K, Kuusisto J, Gylling H, Laakso M. 2012. Journal of hepatology. 56: 663-670

Vaikeasti sairaan ravitsemus

Pihlajamäki J, Gylling H, Schwab U. 2012. Duodecim. 128: 1733-4

Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men

Vangipurapu J, Stancakova A, Pihlajamäki J, Kuulasmaa TM, Kuulasmaa T, Paananen J, Kuusisto J, Ferrannini E, Laakso M. 2011. Diabetologia. 54: 563-571

Expression of the Splicing Factor Gene SFRS10 Is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis

Pihlajamäki Jussi, Lerin Carles, Itkonen Paula, Boes Tanner, Thomas Floss Thomas, Schroeder Joshua, Dearie Farrell, Crunkhorn Sarah, Burak Furkan, Jimenez-Chillaron Josep C., Kuulasmaa Tiina, Miettinen Pekka, Park Peter J., Nasser Imad, Zhao Zhenwen, Zhang Zhaiyi, Xu Yan, Wurst Wolfgang, Ren Hongmei, Morris Andrew J.Stamm Stefan, Goldfine Allison B., Laakso Markku, Patti Mary Elizabeth. 2011. Cell metabolism. 14: 208-218

Glomerular filtration rate and parathyroid hormone are associated with 1,25-dihydroxyvitamin D in men without chronic kidney disease

Karhapää P, Pihlajamäki J, Pörsti I, Kastarinen M, Mustonen J, Niemelä O, Tuomi H, Kuusisto J.. 2011. Journal of internal medicine. 2011: online

PKC&#948 regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans

Bezy Olivier, Tran Thien T, Pihlajamäki Jussi, Suzuki Ryo, Emanuelli Brice, Winnay Jonathan, Mori Marcelo A, Haas Joel, Biddinger Sudha B, Leitges Michael, Goldfine Allison B, Patti Elizabeth, King George L, Kahn C Ronald. 2011. Journal of clinical investigation. 121: 2504-2517

Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans

Pihlajamäki J, Kuulasmaa T, Kaminska D, Simonen M, Kärjä V, Grönlund S, Käkelä P, Pääkkönen M, Kainulainen S, Punnonen K, Kuusisto J, Gylling H, Laakso M. 2011. Journal of hepatology. 56: 663-670

Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis

Pirinen E, Gylling H, Itkonen P, Yaluri N, Heikkinen S, Pietilä M, Kuulasmaa T, Tusa M, Cerrada-Gimenez M, Pihlajamäki J, Alhonen L, Jänne J, Miettinen TA & Laakso M. 2010. Amino acids. 38: 549-560

Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects

Ruotsalainen E, Stancakova A, Vauhkonen I, Salmenniemi U, Pihlajamäki J, Punnonen K, Laakso M. 2010. Atherosclerosis. 210: 536-541

Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding

Pihlajamäki J, Grönlund S, Simonen M, Käkelä P, Moilanen L, Pääkkönen M, Pirinen E, Kolehmainen M, Kärjä V, Kainulainen S, Uusitupa M, Alhava E, Miettinen TA, Gylling H. 2010. Metabolism: clinical and experimental. 59: 866-872

Diverse associations of 25-hydroxyvitamin D and 1,25-dihydroxy-vitamin D with dyslipidaemias

Karhapää P, Pihlajamäki J, Pörsti I, Kastarinen M, Mustonen J, Niemelä P, Kuusisto J. 2010. Journal of internal medicine. 268: 604-610

Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity. Lessons from the METSIM study.

Gylling H, Hallikainen M, Pihlajamaki J, Simonen P, Kuusisto J, Laakso M, Miettinen TA.. 2010. Journal of lipid research. 51: 2422-2427

SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity

Rutanen J, Yaluri N, Modi S, Pihlajamäki J, Vänttinen M, Itkonen P, Kainulainen S, Yamamoto H, Lagouge M, ..., Laakso M. 2010. Diabetes. 59: 829-835

The Pro12Ala polymorphism of the PPARgamma2 gene is associated with hepatic glucose uptake during hyperinsulinwmia in subjects with type 2 diabetes mellitus

Honka M-J, Vänttinen M, Iozzo P, Virtanen KA, Lautamäki R, Hällsten K, Borra RJH, Takala T, Viljanen APM, Kemppainen J, Pihlajamäki J, Knuuti J, Nuutila P, Laakso M. 2009. Metabolism: clinical and experimental. 58: 541-546

The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease

Gylling H, Hallikainen M, Rajaratnam RA, Simonen P, Pihlajamäki J, Laakso M, Miettinen TA. 2009. Metabolism: clinical and experimental. 58: 401-407

High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects

Hammerstedt A, Pihlajamäki J, Graham TE, Kainulainen S, Kahn BB, Laakso M, Smith U. 2008. Journal of internal medicine. 263: 440-449

Markes of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects

Ruotsalainen E, Vauhkonen I, Salmenniemi U, Pihlajamäki J, Punnonen K, Kainulainen S, Jalkanen S, Salmi M, Laakso M. 2008. Atherosclerosis. 197: 271-277

Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance

Stancáková A, Pihlajamäki J, Kuusisto J, Stefan N, Fritsche A, Häring H, Andreozzi F, Succurro E, Sesti G, Boesgaard TW, Hansen T, Pedersen O, Jansson PA, Hammarstedt A, Smith U, Laakso M, for the EUGENE2 Consortium. 2008. Journal of clinical endocrinology and metabolism. 93: 1924-1930

Cholesterol metabolism and non-cholesterol sterol distribution in lipoproreins of type 1 diabetes: The effect of improved glycemic control

Sittiwet C, Gylling H, Hallikainen M, Pihlajamäki J, Moilanen L, Laaksonen DE, Niskanen L, Ågren JJ, Laakso M, Miettinen TA. 2007. Atherosclerosis. 194: 465-472

Cholesterol synthesis prevails over absorption in metabolic syndrome

Gylling H, Hallikainen M, Kolehmainen M, Toppinen L, Pihlajamäki J, Mykkänen H, Ågren JJ, Rauramaa R, Laakso M, Miettinen TA. 2007. Translational research. 149: 310-316

Serum adipokines are associated with cholesterol metabolism in the metabolic syndrome

Hallikainen M, Kolehmainen M, Schwab U, Laaksonen DE, Niskanen L, Rauramaa R, Pihlajamäki J, Uusitupa M, Miettinen TA, Gylling H, Kolehmainen M. 2007. Clinica chimica acta. 383: 126-132

Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans

Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Kuusisto J, Laakso M. 2007. Obesity. 15: 2902-2907

Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects

Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Laakso M, Laakso M. 2007. Journal of clinical endocrinology and metabolism. 92: 1112-1117

Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzhimer¿s disease in the Finnish population

Koivisto AM, Helisalmi S, Pihlajamäki J, Hiltunen M, Koivisto K, Moilanen L, Kuusisto J, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso M, Soininen H, Koivisto AM, Helisalmi S, Hiltunen M, Soininen H, Laakso M. 2006. Dementia and geriatric cognitive disorders. 22: 449-453

Changes in inflammatory cytokines are related to impaired glucose tolerance in offspring of type 2 diabetic subjects

Ruotsalainen E, Salmenniemi U, Vauhkonen I, Pihlajamäki J, Punnonen K, Kainulainen S, Laakso M. 2006. Diabetes care. 29: 2714-2720

Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes

Pihlajamäki J, Salmenniemi U, Vänttinen M, Ruotsalainen E, Kuusisto J, Vauhkonen I, Kainulainen S, Ng MCY, Cox NJ, Bell CI, Laakso M, Laakso M. 2006. Diabetologia. 49: 1560-1566

Endothelial function in hypercholesterolemic subjects: Effects of plant stanol and sterol esters

Hallikainen M, Lyyra-Laitinen T, Laitinen T, Ågren JJ, Pihlajamäki J, Rauramaa R, Miettinen TA, Gylling H. 2006. Atherosclerosis. 188: 425-432

Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease

Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma V-M, Naukkarinen A, Laakso M. 2006. Scandinavian journal of gastroenterology. 41: 191-199

HLA genotyping is useful in the evaluation of the risk for coelic disease in the 1st-degree relatives of patients with coeliac disease

Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma V-M, Naukkarinen A, Laakso M, Laakso M. 2006. Scandinavian journal of gastroenterology. 41: 1299-1304

Visceral obesity is associated with high levels of serum squalene

Peltola P, Pihlajamäki J, Koutnikova H, Ruotsalainen E, Salmenniemi U, Vauhkonen I, Kainulainen S, Gylling H, Miettinen TA, Auwerx J, Laakso M, Laakso M. 2006. Obesity. 14: 1155-1163

Visfatin is an adipokine, but it is not regulated by Thiazolidinediones

Hammarstedt A, Pihlajamäki J, Sopasakis VR, Gogg S, Jansson P-A, Laakso M, Smith U. 2006. Journal of clinical endocrinology and metabolism. 91: 1181-1184

Association of adiponectin level and variants in the adiponectin gene with glucose metabolism, energy expenditure, and cytokines in offspring of type 2 diabetic patients

Salmenniemi U, Zacharova J, Ruotsalainen E, Vauhkonen I, Pihlajamäki J, Kainulainen S, Punnonen K, Laakso M, Laakso M. 2005. Journal of clinical endocrinology and metabolism. 90: 4216-4223

Genetics and phenotypic characteristics of autosomal dominant polycystic kidney disease in Finns

Peltola P, Lumiaho A, Miettinen R, Pihlajamäki J, Sandford R, Laakso M, Laakso M. 2005. Journal of molecular medicine: jmm. 83: 638-646

Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offpring of patients with type 2 diabetes

Pihlajamäki J, Kinnunen M, Ruotsalainen E, Salmenniemi U, Vauhkonen I, Kuulasmaa T, Kainulainen S, Laakso M, Laakso M. 2005. Diabetologia. 48: 1331-1334

High amount of visceral fat mass is associated with multiple metabolic changes in offspring of type 2 diabetic patients

Salmenniemi U, Ruotsalainen E, Vänttinen M, Vauhkonen I, Pihlajamäki J, Kainulainen S, Punnonen K, Laakso M. 2005. International journal of obesity. 29: 1464-1470

Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake

Vänttinen M, Nuutila P, Kuulasmaa T, Pihlajamäki J, Hällsten K, Virtanen KA, Lautamäki R, Peltoniemi P, Takala T, Viljanen APM, Knuuti J, Laakso M, Laakso M. 2005. Diabetes. 54: 3587-3591

The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-gamma2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study

Vänttinen M, Nuutila P, Pihlajamäki J, Hällsten K, Virtanen KA, Lautamäki R, Peltoniemi P, Kemppainen J, Takala T, Viljanen APM, Knuuti J, Laakso M, Laakso M. 2005. Journal of clinical endocrinology and metabolism. 90: 4249-4254

Aldose reductase gene polymorphisms and peripheral nerve function in patients with type 2 diabetes

Sivenius K, Pihlajamäki J, Partanen J, Niskanen L, Laakso M, Uusitupa M. 2004. Diabetes care. 27: 2021-2026

Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes

Laukkanen O, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämaläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, for the Finnish Diabetes Prevention Study Group, Laakso M. 2004. Diabetologia. 47: 871-877

Genomewide search and association studies in a Finnish celiac disease population: identification of a novel locus and replication of HLA and CTLA4 loci

Rioux JD, Karinen H, Kocher K, McMahon SG, Kärkkäinen P, Janatuinen E, Heikkinen M, Julkunen R, Pihlajamäki J, Naukkarinen A, Kosma V-M, Daly MJ, Lander ES, Laakso M, Laakso M. 2004. American journal of medical genetics. Part A. 130: 345-350

Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men

Pihlajamäki J, Gylling H, Miettinen TA, Laakso M. 2004. Journal of lipid research. 45: 507-512

Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome

Salmenniemi U, Ruotsalainen E, Pihlajamäki J, Vauhkonen I, Kainulainen S, Punnonen K, Vanninen E, Laakso M. 2004. Circulation. 110: 3842-3848

Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorbtion and insulin sensitivity

Gylling H, Hallikainen M, Pihlajamäki J, Ågren J, Laakso M, Rajaratnam RA, Rauramaa R, Miettinen TA, Laakso M. 2004. Journal of lipid research. 45: 1660-1665

Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish diabetes prevention study

Laukkanen O, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, for the Finnish diabetes prevention study group. 2004. Journal of clinical endocrinology and metabolism. 89: 6286-6290

The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study

Todorova B, Kubaszek A, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, Laakso M. 2004. Journal of clinical endocrinology and metabolism. 89: 2019-2023

The Pro12Ala polymorphism of the PPARgamma2 gene regulates weight from birth to adulthood

Pihlajamäki J, Vanhala M, Vanhala P, Laakso M, Laakso M. 2004. Obesity. 12: 187-190

The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain

Rutanen J, Pihlajamäki J, Karhapää P, Vauhkonen I, Kuusisto J, Moilanen Mykkänen L, Laakso M, Laakso M. 2004. Obesity. 12: 1060-1066

Insulin resistance is related to left ventricular hyperthrophy in patients with polycystic kidney disease type 1

Lumiaho A, Pihlajamäki J, Hartikainen J, Ikäheimo R, Miettinen R, Niemitukia L, Lampainen E, Laakso M. 2003. American journal of kidney diseases. 41: 1219-1224

Progression of kidney disease varies between families with defects in the polycystic kidney disease type 1 gene in eastern Finland

Lumiaho A, Ikäheimo R, Pihlajamäki J, Miettinen R, Niemitukia L, Vanninen R, Lampainen E, Laakso M. 2003. SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY. 37: 352-358

Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in Finnish subjects

Kossila M, Pihlajamäki J, Kärkkäinen P, Miettinen R, Kekäläinen P, Vauhkonen I, Ylä-Herttuala S, Laakso M, Laakso M. 2003. Diabetes care. 26: 179-182

Promoter polymorphisms of the TNF-alfa (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study

Kubaszek A, Pihlajamäki J, Komarovski V, Lindi V, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, Laakso M. 2003. Diabetes. 52: 1872-1876

The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity

Kubaszek A, Pihlajamäki J, Punnonen K, Karhapää P, Vauhkonen I, Laakso M, Laakso M. 2003. Diabetes. 52: 558-561

The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia

Kubaszek A, Pihlajamäki J, Karhapää P, Vauhkonen I, Laakso M, Laakso M. 2003. Diabetes care. 26: 464-467

The Leu7Pro polymorphism of the neuropeptide Y gene regulates free fatty acid metabolism

Pihlajamäki J, Karhapää P, Vauhkonen I, Kekäläinen P, Kareinen A, Viitanen L, Pesonen U, Kallio J, Uusitupa M, Laakso M. 2003. Metabolism: clinical and experimental. 52: 643-646

The effect of the -308A allele of the TNF-alfa gene on insulin action is dependent on obesity

Pihlajamäki J, Ylinen M, Karhapää P, Vauhkonen I, Laakso M. 2003. Obesity. 11: 912-917

Genetic influences contributing to LDL particle siz in familial combined hyperlipidaemia

Vakkilainen J, Pajukanta P, Cantor RM, Nuotio IO, Lahdenperä S, Ylitalo K, Pihlajamäki J, Kovanen PT, Laakso M, Viikari JSA, Peltonen L, Taskinen M-R. 2002. European journal of human genetics. 10: 547-552

Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland

Jääskeläinen P, Kuusisto J, Miettinen R, Kärkkäinen P, Kärkkäinen S, Heikkinen S, Peltola P, Pihlajamäki J, Vauhkonen I, Laakso M. 2002. Journal of molecular medicine: jmm. 80: 412-422

A major gene effect on fasting insulin and insulin sensitivity in familial combined hyperlipidemia

Pihlajamäki J, Austin M, Edwards K, Laakso M. 2001. Diabetes. 50: 2396-2401

Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease

Viitanen L, Pihlajamäki J, Miettinen R, Kärkkäinen P, Vauhkonen I, Halonen P, Kareinen A, Lehto S, Laakso M. 2001. Journal of molecular medicine: jmm. 79: 732-737

Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease

Viitanen L, Pihlajamäki J, Halonen P, Lehtonen M, Kareinen A, Lehto S, Laakso M. 2001. Atherosclerosis. 157: 57-64

The hormone sensitive lipase gene in familial combined hyperlipidemia and insulin resistance

Pihlajamäki J, Valve R, Karjalainen L, Karhapää P, Vauhkonen I, Laakso M. 2001. European journal of clinical investigation. 31: 302-308

G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia

Pihlajamäki J, Karjalainen L, Karhapää P, Vauhkonen I, Taskinen M-R, Deeb SS, Laakso M. 2000. Arteriosclerosis, thrombosis, and vascular biology. 20: 1789-95

Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hypertriglyceridemic paitients

Pihlajamäki J, Karjalainen L, Karhapää P, Vauhkonen I, Laakso M. 2000. Arteriosclerosis, thrombosis, and vascular biology. 20: 164-170

Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin

Rissanen J, Markkanen A, Kärkkäinen P, Pihlajamäki J, Kekäläinen P, Mykkänen L, Kuusisto J, Karhapää P, Niskanen L, Laakso M. 2000. Diabetes care. 23: 70-73

The Pro12Ala substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with d

Pihlajamäki J, Miettinen R, Valve R, Karjalainen L, Mykkänen L, Kuusisto J, Deeb S, Auwerx J, Laakso M. 2000. Atherosclerosis. 151: 567-574

Genomewide scan for familial combined hyperlipidemia genes in Finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels

Pajukanta P, Terwilliger JD, Perola M, Hiekkalinna T, Nuotio I, Ellonen P, Parkkonen M, Hartiala J, Ylitalo K, Pihlajamäki J, Porkka K, Laakso M, Viikari J, Ehnholm C, Taskinen M-R, Peltonen L. 1999. American journal of human genetics. 64: 1453-1463

Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women

Valve R, Sivenius K, Miettinen R, Pihlajamäki J, Rissanen A, Deeb SS, Auwerx J, Uusitupa M, Laakso M. 1999. Journal of clinical endocrinology and metabolism. 84: 3708-3712

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

Deeb SS, Fajas L, Nemoto M, Pihlajamäki J, Mykkänen L, Kuusisto J, Laakso M, Fujimoto W, Auwerx J. 1998. Nature genetics

Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia

Pihlajamäki J, Rissanen J, Valve R, Heikkinen S, Karjalainen L, Laakso M. 1998. Metabolism: clinical and experimental. 47: 1397-1402

Impaired insulin-stimulated glucose oxidation and free fatty acid suppression in patients with familial combined hyperlipidemia: a precursor defect for dyslipidemia?

Karjalainen L, Pihlajamäki J, Karhapää P, Laakso M. 1998. Arteriosclerosis, thrombosis, and vascular biology. 18: 1548-1553

Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23

Pajukanta P, Nuotio I, Terwilliger JD, Porkka KVK, Ylitalo K, Pihlajamäki J, Suomalainen AJ, Syvänen A-C, Lehtimäki T, Viikari JSA, Laakso M, Taskinen M-R, Ehnholm C, Peltonen L. 1998. Nature genetics. 18: 369-373

The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population

Jääskeläinen P, Soranta M, Miettinen R, Saarinen L, Pihlajamäki J, Silvennoinen K, Tikanoja T, Laakso M, Kuusisto J. 1998. Journal of the american college of cardiology. 32: 1709-1716

Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia

Pihlajamäki J, Rissanen J, Heikkinen S, Karjalainen L, Laakso M. 1997. Arteriosclerosis, thrombosis, and vascular biology. 17: 1039-1044

New variants in the glycogen synthase gene (GIn71His, Met416Val) in patients with NIDDM from eastern Finland

Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Mykkänen L, Kuusisto J, Kolle A, Laakso M. 1997. Diabetologia. 40: 1313-1319

The ala54thr polymorphism of the fatty acid binding protein 2 gene does not influence insulin sensitivity in Finnish nondiabetic and NIDDM subjects

Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Kuusisto J, Laakso M. 1997. Diabetes. 46: 711-712

The trp64arg polymorphism of the beta3-adrenergic receptor gene

Rissanen J, Kuopusjärvi M, Pihlajamäki J, Sipiläinen R, Heikkinen S, Vanhala M, Kekäläinen P, Kuusisto J, Laakso M. 1997. Diabetes care. 20: 1319-1323

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Research groups

Associations of Lifestyle Patterns with Glucose and Lipid Metabolism in Finnish Adults at Increased Risk of Type 2 Diabetes

Dietary n-3 alpha-linolenic and n-6 linoleic acids modestly lower serum lipoprotein(a) concentration but differentially influence other atherogenic lipoprotein traits: A randomized trial

Effectiveness of workplace choice architecture modification for healthy eating and daily physical activity

Hepatokine ITIH3 protects against hepatic steatosis by downregulating mitochondrial bioenergetics and de novo lipogenesis

IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids

Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity

Modification in mitochondrial function is associated with the FADS1 variant and its interaction with alpha-linolenic acid-enriched diet - an exploratory study

Protein Phosphatase 1 Regulatory Subunit 3 Beta rs4240624 Genotype Is Associated With Gallstones and With Significant Changes in Bile Lipidome

Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease

Temporal Alterations in CD8+ T Cells During the Progression from Stage 1 to Stage 3 Type 1 Diabetes

m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1

Acceptability of workplace choice architecture modification for healthy behaviours

Associations Between Engagement with the BitHabit Digital Lifestyle Intervention and Changes in Type 2 Diabetes Risk Factors

Changes in liver metabolic pathways demonstrate efficacy of the combined dietary and microbial therapeutic intervention in MASLD mouse model

Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans

Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease

Dekaanin tervehdys

Evaluation of plasma IL-21 as a potential biomarker for type 1 diabetes progression

High estradiol levels during a long agonist IVF protocol are associated with decreased food intake, higher leptin concentrations, and lower levels of high-sensitivity C-reactive protein

Liraglutide demonstrates a therapeutic effect on mitochondrial dysfunction in human SGBS adipocytes in vitro

Liver saturated fat content associates with hepatic DNA methylation in obese individuals

Programmed cell death 1 genetic variant and liver damage in nonalcoholic fatty liver disease

“Role of Matrix Gla Protein in Transforming Growth Factor-β Signaling and Non-Alcoholic Steatohepatitis in Mice”

Associations between weight loss history and factors related to type 2 diabetes risk in the Stop Diabetes study

Digitally Supported Lifestyle Intervention to Prevent Type 2 Diabetes Through Healthy Habits: Secondary Analysis of Long-Term User Engagement Trajectories in a Randomized Controlled Trial

Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease

Identification of 90 NAFLD GWAS loci and establishment of NAFLD PRS and causal role of NAFLD in coronary artery disease

Immigrants’ perspectives on healthy life and healthy lifestyle counseling: a focus group study

Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease

PSD3 downregulation confers protection against fatty liver disease

Rare ATG7 genetic variants predispose patients to severe fatty liver disease

Real-world effectiveness of digital and group-based lifestyle interventions as compared with usual care to reduce type 2 diabetes risk – A stop diabetes pragmatic randomised trial

Sensory Appeal and Routines Beat Health Messages and Visibility Enhancements: Mixed-Methods Analysis of a Choice-Architecture Intervention in a Workplace Cafeteria

The FADS1 genotypes modify the effect of linoleic acid-enriched diet on adipose tissue inflammation via pro-inflammatory eicosanoid metabolism

The FADS1 rs174550 Genotype Modifies the n‐3 and n‐6 PUFA and Lipid Mediator Responses to a High Alpha‐Linolenic Acid and High Linoleic Acid Diets

Choice Architecture Cueing to Healthier Dietary Choices and Physical Activity at the Workplace: Implementation and Feasibility Evaluation

Comparison of Communication Channels for Large-Scale Type 2 Diabetes Risk Screening and Intervention Recruitment: Empirical Study

Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery

Digitalization as an Engine for Change? Building a Vision Pathway towards a Sustainable Health Care System by Using the MLP and Health Economic Decision Modelling

Endothelial function and concentrations of high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha during a long agonist IVF protocol

Enhanced Eating Competence Is Associated with Improved Diet Quality and Cardiometabolic Profile in Finnish Adults with Increased Risk of Type 2 Diabetes

Exome-wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated with Fatty Liver Disease

FADS1 rs174550 genotype and high linoleic acid diet modify plasma PUFA phospholipids in a dietary intervention study

Formation and Validation of the Healthy Diet Index (HDI) for Evaluation of Diet Quality in Healthcare

Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

NR1H4 rs35724 G>C Variant Modulates Liver Damage in Nonalcoholic Fatty Liver Disease

Oxygen-18 and Carbon-13 isotopes in eCO 2 and erythrocytes carbonic anhydrase activity of Finnish prediabetic population

Sleep-time physiological recovery is associated with eating habits in distressed working-age Finns with overweight: secondary analysis of a randomised controlled trial

The FADS1 Genotype Modifes Metabolic Responses to the Linoleic Acid and Alpha-linolenic Acid Containing Plant Oils-Genotype Based Randomized Trial FADSDIET2

Change in abdominal, but not femoral subcutaneous fat CT-radiodensity is associated with improved metabolic profile after bariatric surgery

Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques

Dietary fiber from oat and rye brans ameliorate Western diet-induced body weight gain and hepatic inflammation by the modulation of short chain fatty acids, bile acids, and tryptophan metabolism

Effect of metabolic state on implicit and explicit responses to food in young healthy females

Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes

Genetic variants in the MTHFR are not associated with fatty liver disease.

Internet-Based Lifestyle Intervention to Prevent Type 2 Diabetes Through Healthy Habits: Design and 6-Month Usage Results of Randomized Controlled Trial

LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover

Miten tyypin 2 diabeteksen ehkäisy pitäisi järjestää?

Mucosal-associated invariant T cell alterations during the development of human type 1 diabetes

PCSK9 rs11591147 R46L loss-of-function variant protects against liver damage in individuals with NAFLD

Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice

Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition

Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids

StopDia-hankkeesta vinkkejä terveyden edistämiseen ja hyte-johtamiseen

StopDian opetukset: viesti vahvasti ja tee osallistuminen helpoksi

The Effects of Acceptance and Commitment Therapy (ACT) Intervention on Inflammation and Stress Biomarkers: a Randomized Controlled Trial

The effect of different estradiol levels on carotid artery distensibility during a long agonist IVF protocol

An Isocaloric Nordic Diet Modulates RELA and TNFRSF1A Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome-A SYSDIET Sub-Study

Association of fatty liver disease with mortality outcomes in an Eastern Finland male cohort

Association of fatty liver index with risk of incident type 2 diabetes by metabolic syndrome status in an Eastern Finland male cohort: a prospective study

Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study

Digitally supported program for type 2 diabetes risk identification and risk reduction in real-world setting: protocol for the StopDia model and randomized controlled trial

Eating Competence Is Associated with Lower Prevalence of Obesity and Better Insulin Sensitivity in Finnish Adults with Increased Risk for Type 2 Diabetes: The StopDia Study

Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study

Fatty liver index as a predictor of increased risk of cardiometabolic disease: finding from the Kuopio Ischaemic Heart Disease Risk Factor Study Cohort