
KRISTIINA HUTTUNEN
Senior Researcher
Senior Researcher Group Leader
Prodrug expert and group leader (Docent/Adjunct Professor, Ph.D.), who is interested in drug targeting, e.g. into the brain and within the brain, but also into other tissues and cell types by utilizing endogenous transporter proteins. Read more about our activities from the UEF Connect group site, our official websites (Wordpress) and/or our Blog (links below).
Contact info
Organization
Faculty of Health Sciences, School of Pharmacy
kristiina.huttunen@uef.fi
Phone
+358 40 355 3684
Keywords
drug analysis
drug delivery
drug synthesis
drug targeting
intrabrain drug delivery and targeting
medicinal chemistry
pharmaceutical chemistry
pharmacokinetics
pharmacy
prodrug
solute carriers
transporter-mediated targeted drug delivery
transporters
Teaching Activities
Course Director of Organic Synthesis – Laboratory Work (5 ECTS), running yearly at the School of Pharmacy during the spring semester
Supervisor of Bachelor, Master and Doctoral Thesis as well as project works of ERASMUS students
Research groups - UEF
Links
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Transporter-Targeted Drug Delivery Official Website
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Research Groups' Blog
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Personal LinkedIn
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Perosnal ResearchGate
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Personal ORCID
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LinkedIn LinkedIn
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Blogger Transporter-mediated Targeted Drug Delivery
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Research gate Research Gate
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Orcid ORCID
Publications
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Kärkkäinen, Jussi; Laitinen, Tuomo; Markowicz-Piasecka, Magdalena; Montaser, Ahmed; Lehtonen, Marko; Rautio, Jarkko; Gynther, Mikko; Poso, Antti; Huttunen, Kristiina M. 2021. Molecular characteristics supporting L-Type amino acid transporter 1 (LAT1)-mediated translocation Bioorganic chemistry 112: 104921. 2021
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Tampio, Janne; Löffler, Susanne; Guillon, Melina; Hugele, Agathe; Huttunen, Johanna; Huttunen, Kristiina M.. 2021. Improved L-Type Amino Acid Transporter 1 (LAT1)-Mediated Delivery of Anti-Inflammatory Drugs into Astrocytes and Microglia with Reduced Prostaglandin Production International journal of pharmaceutics 601: 120565. 2021
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Tampio, Janne; Markowicz-Piasecka, Magdalena; Huttunen, Kristiina M.. 2021. Hemocompatible L-Type amino acid transporter 1 (LAT1)-Utilizing prodrugs of perforin inhibitors can accumulate into the pancreas and alleviate inflammation-induced apoptosis Chemico-biological interactions 345: 109560. 2021
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Montaser, Ahmed; Markowicz-Piasecka, Magdalena; Sikora, Joanna; Jalkanen, Aaro; Huttunen, Kristiina M. 2020. L-Type Amino Acid Transporter 1 (LAT1)-Utilizing Efflux Transporter Inhibitors Can Improve the Brain Uptake and Apoptosis-Inducing Effects of Vinblastine in Cancer Cells International journal of pharmaceutics 586: 119585. 2020
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Tampio, Janne; Huttunen, Johanna; Montaser, Ahmed; Huttunen, Kristiina M. 2020. Targeting of Perforin Inhibitor into the Brain Parenchyma Via a Prodrug Approach Can Decrease Oxidative Stress and Neuroinflammation and Improve Cell Survival Molecular neurobiology 57 11: 4563-4577. 2020
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Montaser, Ahmed B; Järvinen, Juulia; Löffler, Susanne; Huttunen, Johanna; Auriola, Seppo; Lehtonen, Marko; Jalkanen, Aaro; Huttunen, Kristiina M. 2020. L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells Acs chemical neuroscience 11 24: 4301-4315. 2020
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Markowicz-Piasecka, Magdalena; Huttunen, Johanna; Montaser, Ahmed; Huttunen, Kristiina. 2020. Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis Apoptosis 26 5-6: 426-440. 2020
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Huttunen, Johanna; Gynther, Mikko; Vellonen, KatiSisko; Huttunen, Kristiina M. 2019. L-Type Amino Acid Transporter 1 (LAT1)-Utilizing Prodrugs Are Carrier-Selective Despite Having Low Affinity for Organic Anion Transporting Polypeptides (OATPs) International journal of pharmaceutics 571: 118714. 2019
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Huttunen J, Peltokangas S, Gynther M, Natunen T, Hiltunen M, Auriola S, Ruponen M, Vellonen KS, Huttunen KM. 2019. L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia Scientific reports 9: 12860. 2019
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Huttunen, Kristiina M. 2018. Identification of human, rat and mouse hydrolyzing enzymes bioconverting amino acid ester prodrug of ketoprofen Bioorganic chemistry 81: 494-503. 2018