Luca Giudice
Postdoctoral Researcher
Bioinformatician | Data Scientist
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
I am the first in Italy to have completed a full academic career in Bioinformatics. As a Postdoctoral Researcher, I specialize in bioinformatics, data analysis, network science, and artificial intelligence. I focus on developing and applying machine learning to patient similarity networks for investigating neurological disorders, such as Simpati and StellarPath methods to study Alzheimer’s disease and Stroke. I am particularly interested in networks because they transform complex data into interpretable graphs (helping in pattern recognition), and offer an interpretable and explanative data structure for machine learning algorithms. My experience includes successfully solving real biological problems, collaborating with experts in various scientific fields, and self-learning mathematical and biomedical concepts.
Research groups
Publications
12/12 items-
Germinal center trajectories and transcriptional signatures define CLL subtypes and their pathway regulators
Mohamed, Ahmed; Giudice, Luca; Basílio, José; Barresi, Sabina; Kopparapu, Pradeep Kumar; Friman, Vanda; Tartaglia, Marco; Malm, Tarja; Tilevik, Andreas; Grimsholm, Ola, 2025, PLoS ONE, 20, 10, e0335069. A1 Journal article (refereed), original research -
Increased activity of Piezo1 channel in red blood cells is associated with Alzheimer's disease-related dementia
Sitnikova, Valeriia; Nurkhametova, Dilyara; Braidotti, Nicoletta; Ciubotaru, Catalin, D; Giudice, Luca; Impola, Ulla; Kärkkäinen, Sari;Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Fagerlund, Ilkka; Kanninen, Katja, M; Zetterberg, Henrik; Kokkola, Tarja; Laitinen Saara; Koivisto, Anne; Cojoc, Dan; Giniatullin, Rashid; Malm, Tarja, M, 2025, Alzheimer's & dementia, 21, 6, e70368. A1 Journal article (refereed), original research -
Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state
Hyvärinen, Tanja; Tilvis, Johanna; Giudice, Luca; Tujula, Iisa; Nylund, Marjo; Ohtonen, Sohvi; Scoyni, Flavia; Jäntti, Henna; Virtanen, Lassi; Pihlava, Sara; Kattelus, Roosa; Skottman, Heli; Narkilahti, Susanna; Airas, Laura; Malm, Tarja; Hagman, Sanna, 2025, Journal of neuroinflammation, 22, 1, 255. A1 Journal article (refereed), original research -
Traffic-related diesel pollution particles impair the lysosomal functions of human iPSC-derived microglia
Ohtonen, Sohvi; Jäntti, Henna; Giudice, Luca; Mohamed, Ahmed; Shakirzyanova, Anastasia; Závodná, Táňa; Belevich, Ilya; Yan, Hong; Sabogal-Guáqueta, Angélica María; Saveleva, Liudmila; Väänänen, Mari-Anna; Rillo-Albert, Ashley; Perciballi, Elisa; Ferrari, Daniela; Tervo, Minna-Mari; Gómez-Budia, Mireia; Krejčík, Zdeněk; Aakko-Saksa, Päivi; Koistinaho, Jari; Lehtonen, Šárka; Kanninen, Katja M.; Topinka, Jan; Jokitalo, Eija; Sierra, Alejandra; Schmidt, Martina; Dolga, Amalia M.; Jalava, Pasi I.; Ko, 2025, Environment international, 199, 109467. A1 Journal article (refereed), original research -
StellarPath: Hierarchical-vertical multi-omics classifier synergizes stable markers and interpretable similarity networks for patient profiling
Giudice, Luca; Mohamed, Ahmed; Malm, Tarja, 2024, PLoS computational biology, 20, 4, e1012022. A1 Journal article (refereed), original research -
Uptake of alpha‐synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia
Niskanen, Jonna; Peltonen, Sanni; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Luk, Kelvin C; Giudice, Luca; Koistinaho, Jari; Malm, Tarja; Goldsteins, Gundars; Albert, Katrina; Lehtonen, Šárka, 2024, Glia, 2025; 73, 1, 159-174. A1 Journal article (refereed), original research -
ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling
Scoyni, Flavia; Sitnikova, Valeriia; Giudice, Luca; Korhonen, Paula; Trevisan, Davide M; Hernandez de Sande, Ana; Gomez-Budia, Mireia; Giniatullina, Raisa; Ugidos, Irene F; Dhungana, Hiramani; Pistono, Cristiana; Korvenlaita, Nea; Välimäki, Nelli-Noora; Kangas, Salla M; Hiltunen, Anniina E; Gribchenko, Emma; Kaikkonen-Määttä, Minna U; Koistinaho, Jari; Ylä-Herttuala, Seppo; Hinttala, Reetta; Venø, Morten T; Su, Junyi; Stoffel, Markus; Schaefer, Anne; Rajewsky, Nikolaus; Kjems, Jørgen; LaPierre,, 2024, Cell reports, 43, 3, 113862. A1 Journal article (refereed), original research -
Alzheimer's disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs
Scoyni, Flavia; Giudice, Luca; Väänänen, Mari Anna; Downes, Nicholas; Korhonen, Paula; Choo, Xin Yi; Välimäki, Nelli Noora; Mäkinen, Petri; Korvenlaita, Nea; Rozemuller, Annemieke J; de Vries, Helga E; Polo, Jose; Turunen, Tiia A; Ylä-Herttuala, Seppo; Hansen, Thomas B; Grubman, Alexandra; Kaikkonen, Minna U; Malm, Tarja, 2023, Alzheimer's & dementia, 2024; 20, 2, 954-974. A1 Journal article (refereed), original research -
Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia
Korvenlaita, Nea; Gómez‐Budia, Mireia; Scoyni, Flavia; Pistono, Cristiana; Giudice, Luca; Eamen, Shaila; Loppi, Sanna; de Sande, Ana Hernández; Huremagic, Benjamin; Bouvy‐Liivrand, Maria; Heinäniemi, Merja; Kaikkonen, Minna U.; Cheng, Lesley; Hill, Andrew F.; Kanninen, Katja M.; Jenster, Guido W.; van Royen, Martin E.; Ramiro, Laura; Montaner, Joan; Batkova, Tereza; Mikulik, Robert; Giugno, Rosalba; Jolkkonen, Jukka; Korhonen, Paula; Malm, Tarja, 2023, Journal of extracellular vesicles, 12, 1, 12297. A1 Journal article (refereed), original research -
Esearch3D: propagating gene expression in chromatin networks to illuminate active enhancers
Heer, Maninder; Giudice, Luca; Mengoni, Claudia; Giugno, Rosalba; Rico, Daniel, 2023, Nucleic acids research, 51, 10, e55. A1 Journal article (refereed), original research
