Maija Lahtela-Kakkonen
Senior Researcher
Adjunct Professor Drug Design
School of Pharmacy, Faculty of Health Sciences
[email protected] | +358 40 355 3692
We are studying epigenetic regulators involved in histone acetylation. We use drug design methods for identifying novel inhibitors and activators, and study their impact with in vitro assays and in various cell lines. We are focused on class III histodecatylases (HDACs) and Bromodomains (BRDs). In addition we are identifying novel compounds for various other targets such as prolyloligopeptidase (POP, PREP) and TRPA1, latter is linked in neuropathic pain. We are also modeling transporters and microplastics.
Research groups
Publications
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5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein–Protein Interaction-Derived Functions
Pätsi, Henri T; Kilpeläinen, Tommi P; Jumppanen, Mikael; Uhari-Väänänen, Johanna; Wielendaele, Pieter Van; De Lorenzo, Francesca; Cui, Hengjing; Auno, Samuli; Saharinen, Janne; Seppälä, Erin; Sipari, Nina; Savinainen, Juha; De Meester, Ingrid; Lambeir, Anne-Marie; Lahtela-Kakkonen, Maija; Myöhänen, Timo T; Wallén, Erik AA. 2024. Journal of medicinal chemistry. 67: 5421-5436 A1 Journal article (refereed), original research -
New insights into aflatoxin B1 mechanistic toxicology in cattle liver: an integrated approach using molecular docking and biological evaluation in CYP1A1 and CYP3A74 knockout BFH12 cell lines
Iori, Silvia; Lahtela-Kakkonen, Maija; D’Onofrio, Caterina; Maietti, Federica; Mucignat, Greta; Bardhi, Anisa; Barbarossa, Andrea; Zaghini, Anna; Pauletto, Marianna; Dacasto, Mauro; Giantin, Mery. 2024. Archives of toxicology. 98: 3097-3108 A1 Journal article (refereed), original research -
Novel inhibitors of bromodomain and extra-terminal domain trigger cell death in breast cancer cell lines
Rahnasto-Rilla, Minna; Puumalainen, Tatu; Karttunen, Vilma; Adla, Santosh Kumar; Lahtela-Kakkonen, Maija. 2024. Bioorganic and medicinal chemistry. 112: A1 Journal article (refereed), original research -
TRPA1 Inhibition Effects by 3-Phenylcoumarin Derivatives
Sallomy, Carita; Awolade, Paul; Rahnasto-Rilla, Minna; Hämäläinen, Mari; Nousiainen, Liisa P; Johansson, Niklas G; Hiltunen, Sanna; Turhanen, Petri; Moilanen, Eeva; Lahtela-Kakkonen, Maija; Timonen, Juri M. 2024. Acs medicinal chemistry letters. 15: 1221-1226 A1 Journal article (refereed), original research -
Dynamics behavior of PE and PET oligomers in lipid bilayer simulations
Järvenpää, Joni P; Lahtela-Kakkonen, Maija K. 2023. Microplastics and nanoplastics. 3: . 27 A1 Journal article (refereed), original research -
Farmaseuttinen kemia
Jarho, Pekka; Lahtela-Kakkonen, Maija; Vepsäläinen, Jouko; Rautio, Jarkko; Huttunen, Kristiina; Poso, Antti; Auriola, Seppo. 2023. Publications of the University of Eastern Finland. General series. 44: 32-35 E1 Popularised article, newspaper article -
Micro-sized polyethylene particles affect cell viability and oxidative stress responses in human colorectal adenocarcinoma Caco-2 and HT-29 cells
Herrala, Mikko; Huovinen, Marjo; Järvelä, Essi; Hellman, Julia; Tolonen, Pauliina; Lahtela-Kakkonen, Maija; Rysä, Jaana. 2023. Science of the total environment. 867: A1 Journal article (refereed), original research -
SIRT2i_Predictor: A Machine Learning-Based Tool to Facilitate the Discovery of Novel SIRT2 Inhibitors
Djokovic, Nemanja; Rahnasto-Rilla, Minna; Lougiakis, Nikolaos; Lahtela-Kakkonen, Maija; Nikolic, Katarina. 2023. Pharmaceuticals. 16: A1 Journal article (refereed), original research -
Apteekin toiminnan kehittäminen toimintakäsikirjan ja työryhmätaulukon avulla
Honkanen, Marko; Kangas, Saana; Niskanen, Merja; Vainio, Kirsti; Sepponen, Kati; Lahtela-Kakkonen, Maija . 2022. Dosis. 38: 362-381 A1 Journal article (refereed), original research -
Expanding the Accessible Chemical Space of SIRT2 Inhibitors through Exploration of Binding Pocket Dynamics
Djokovic, Nemanja; Ruzic, Dusan; Rahnasto-Rilla, Minna; Srdic-Rajic, Tatjana; Lahtela-Kakkonen, Maija; Nikolic, Katarina. 2022. Journal of chemical information and modeling. 62: 2571-2585 A1 Journal article (refereed), original research