Mari Takalo
Senior Researcher
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences
[email protected] | +358 50 342 6382
Publications
37/37 items-
Biobank-based genetic characterization of neurodegenerative diseases and idiopathic normal pressure hydrocephalus: insights and lessons learned from FinnGen
Heikkinen, Sami; Julkunen, Valtteri; Martiskainen, Henna; Takalo, Mari; Solje, Eino; Leinonen, Ville; Haapasalo, Annakaisa; Lipponen, Anssi; Hiltunen, Mikko, 2026, Molecular psychiatry, [Published: 12 June 2026], 1-10. A2 Review article, Literature review, Systematic review -
C9orf72-associated and sporadic FTD patient iPSC-microglia show differences in phagocytosis and gene expression
Rostalski, Hannah; Hietanen, Tomi; Hoffmann, Dorit; Heikkinen, Sami; Huber, Nadine; Dhingra, Ashutosh; Rodriguez-Nieto, Salvador; Kuulasmaa, Teemu; Ohtonen, Sohvi; Jäntti, Henna; Pekkala, Viivi; Leskelä, Stina; Mäkinen, Petra; Katisko, Kasper; Hartikainen, Päivi; Lehtonen, Šárka; Solje, Eino; Koistinaho, Jari; Malm, Tarja; Portaankorva, Anne M.; Natunen, Teemu; Martiskainen, Henna; Takalo, Mari; Hiltunen, Mikko; Haapasalo, Annakaisa, 2026, Stem cell reports, 21, 9, 103026. A1 Journal article (refereed), original research -
Genetic validation of ABI3 p.Ser209Phe variant and its effects on early brain pathology in asymptomatic elderly individuals
Koivumäki, Mikko; Martiskainen, Henna; Takalo, Mari; Lehtisalo, Jenni; Ngandu, Tiia; Snellman, Anniina; Hiltunen, Mikko; Rinne, Juha O, 2026, Alzheimer's research and therapy, 18, 67. A1 Journal article (refereed), original research -
Lithium chloride alters Tau phosphorylation, kinase activity, and Rho GTPase signaling in cell models
Hoffmann, Dorit; Ahola, Virpi; Huber, Nadine; Natunen, Teemu; Leskelä, Stina; Takalo, Mari; Martiskainen, Henna; Ballweg, Stephanie; Vorontsov, Egor; Selzer, Stefan; Kallio, Pekka; Pike, Ian; Sirviö, Jouni; Haapasalo, Annakaisa; Hiltunen, Mikko, 2026, Biomedicine and pharmacotherapy, 198, 119347. A1 Journal article (refereed), original research -
PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures
Coulon, Audrey; Rabiller, Florian; Takalo, Mari; Roy, Avishek; Pelletier, Alexandre; Martiskainen, Henna; Siedlecki-Wullich, Dolores; Lannette-Weimann, Nina; Majerníková, Naďa; Grenon, Arthur; Gao, Vance; Erhardt, Anaël; Pernodet, Anne; Lemaire, Morgane; Limoge, Floriane; Walle, Pauline; Mendes, Tiago; Guyot, Karine; Lemeu, Célia; Carvalho, Lukas-Iohan; Melo de Farias, Ana Raquel; Hulsman, Marc; Najdek, Chloé; Freire-Regatillo, Alejandra; Saha, Orthis; Amouyel, Philippe; Charbonnier, Camille; De, 2026, Nature genetics, [Published: 14 August 2026], 1-29. A1 Journal article (refereed), original research -
Protective PLCG2 variants associate with a delayed onset of Alzheimer’s disease among heterozygous APOE ε4 carriers
Jeskanen, Heli; Heikkinen, Sami; Kervinen, Inka; Lehtisalo, Jenni; Ngandu, Tiia; Willman, Roosa-Maria; Rosa, Jessica; Hoffmann, Dorit; Leinonen, Ville; Haapasalo, Annakaisa; Takalo, Mari; Martiskainen, Henna; Hiltunen, Mikko, 2026, Alzheimer's research and therapy, 18, 1, 53. A1 Journal article (refereed), original research -
Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage
Huber, Nadine; Hietanen, Tomi; Heikkinen, Sami; Shakirzyanova, Anastasia; Hoffmann, Dorit; Rostalski, Hannah; Dhingra, Ashutosh; Rodriguez-Nieto, Salvador; Kärkkäinen, Sari; Koskuvi, Marja; Korhonen, Eila; Hartikainen, Päivi; Pylkäs, Katri; Krüger, Johanna; Malm, Tarja; Takalo, Mari; Hiltunen, Mikko; Koistinaho, Jari; Portaankorva, Anne M; Solje, Eino; Haapasalo, Annakaisa, 2025, Molecular psychiatry, 31, 3, 1500-1516. A1 Journal article (refereed), original research -
Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype
Hellén, Marianna; Weert, Isabelle; Müller, Stephan A.; Räsänen, Noora; Kettunen, Pinja; Lehtonen, Šárka; Peitz, Michael; Fließbach, Klaus; Takalo, Mari; Koskuvi, Marja; Lichtenthaler, Stefan F.; Leinonen, Ville; Ramirez, Alfredo; Kärkkäinen, Olli; Hiltunen, Mikko; Koistinaho, Jari; Rõlova, Taisia, 2025, Journal of neuroinflammation, 22, 1, 147. A1 Journal article (refereed), original research -
Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease
Martiskainen, Henna; Willman, Roosa-Maria; Harju, Päivi; Heikkinen, Sami; Heiskanen, Mette; Müller, Stephan A.; Sinisalo, Rosa; Takalo, Mari; Mäkinen, Petra; Kuulasmaa, Teemu; Pekkala, Viivi; Galván del Rey, Ana; Juopperi, Sini-Pauliina; Jeskanen, Heli; Kervinen, Inka; Saastamoinen, Kirsi; Niiranen, Marja; Heikkinen, Sami V.; Kurki, Mitja I.; Marttila, Jarkko; Mäkinen, Petri I.; Rostalski, Hannah; Hietanen, Tomi; Ngandu, Tiia; Lehtisalo, Jenni; Bellenguez, Céline; Lambert, Jean-Charles; Haass, C, 2025, Molecular neurodegeneration, 20, 1, 50. A1 Journal article (refereed), original research -
The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions
Takalo, Mari; Jeskanen, Heli; Rolova, Taisia; Kervinen, Inka; Hellén, Marianna; Heikkinen, Sami; Koivisto, Hennariikka; Jokivarsi, Kimmo; Müller, Stephan A.; Koivumäki, Esa-Mikko; Mäkinen, Petra; Juopperi, Sini-Pauliina; Willman, Roosa-Maria; Sinisalo, Rosa; Hoffmann, Dorit; Jäntti, Henna; Peitz, Michael; Fließbach, Klaus; Kuulasmaa, Teemu; Natunen, Teemu; Kemppainen, Susanna; Poutiainen, Pekka; Leinonen, Ville; Malm, Tarja; Martiskainen, Henna; Ramirez, Alfredo; Haapasalo, Annakaisa; Lichtentha, 2025, Journal of neuroinflammation, 22, 1, 64. A1 Journal article (refereed), original research