Mari Takalo
Senior Researcher
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences
[email protected] | +358 50 342 6382
Publications
31/31 items-
Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage
Huber, Nadine; Hietanen, Tomi; Heikkinen, Sami; Shakirzyanova, Anastasia; Hoffmann, Dorit; Rostalski, Hannah; Dhingra, Ashutosh; Rodriguez-Nieto, Salvador; Kärkkäinen, Sari; Koskuvi, Marja; Korhonen, Eila; Hartikainen, Päivi; Pylkäs, Katri; Krüger, Johanna; Malm, Tarja; Takalo, Mari; Hiltunen, Mikko; Koistinaho, Jari; Portaankorva, Anne M; Solje, Eino; Haapasalo, Annakaisa, 2025, Molecular psychiatry, [Published: 26 September 2025], 1-17. A1 Journal article (refereed), original research -
Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype
Hellén, Marianna; Weert, Isabelle; Müller, Stephan A.; Räsänen, Noora; Kettunen, Pinja; Lehtonen, Šárka; Peitz, Michael; Fließbach, Klaus; Takalo, Mari; Koskuvi, Marja; Lichtenthaler, Stefan F.; Leinonen, Ville; Ramirez, Alfredo; Kärkkäinen, Olli; Hiltunen, Mikko; Koistinaho, Jari; Rõlova, Taisia, 2025, Journal of neuroinflammation, 22, 1, 147. A1 Journal article (refereed), original research -
Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease
Martiskainen, Henna; Willman, Roosa-Maria; Harju, Päivi; Heikkinen, Sami; Heiskanen, Mette; Müller, Stephan A.; Sinisalo, Rosa; Takalo, Mari; Mäkinen, Petra; Kuulasmaa, Teemu; Pekkala, Viivi; Galván del Rey, Ana; Juopperi, Sini-Pauliina; Jeskanen, Heli; Kervinen, Inka; Saastamoinen, Kirsi; Niiranen, Marja; Heikkinen, Sami V.; Kurki, Mitja I.; Marttila, Jarkko; Mäkinen, Petri I.; Rostalski, Hannah; Hietanen, Tomi; Ngandu, Tiia; Lehtisalo, Jenni; Bellenguez, Céline; Lambert, Jean-Charles; Haass, C, 2025, Molecular neurodegeneration, 20, 1, 50. A1 Journal article (refereed), original research -
The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions
Takalo, Mari; Jeskanen, Heli; Rolova, Taisia; Kervinen, Inka; Hellén, Marianna; Heikkinen, Sami; Koivisto, Hennariikka; Jokivarsi, Kimmo; Müller, Stephan A.; Koivumäki, Esa-Mikko; Mäkinen, Petra; Juopperi, Sini-Pauliina; Willman, Roosa-Maria; Sinisalo, Rosa; Hoffmann, Dorit; Jäntti, Henna; Peitz, Michael; Fließbach, Klaus; Kuulasmaa, Teemu; Natunen, Teemu; Kemppainen, Susanna; Poutiainen, Pekka; Leinonen, Ville; Malm, Tarja; Martiskainen, Henna; Ramirez, Alfredo; Haapasalo, Annakaisa; Lichtentha, 2025, Journal of neuroinflammation, 22, 1, 64. A1 Journal article (refereed), original research -
Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates
Kemppainen, Susanna; Huber, Nadine; Willman, Roosa-Maria; Zamora, Ana; Makinen, Petra; Martiskainen, Henna; Takalo, Mari; Haapasalo, Annakaisa; Sobrino, Tomas; Gomez, Manuel Antonio Gonzalez; Pineiro, Yolanda; Rivas, Jose; Himmelreich, Uwe; Hiltunen, Mikko, 2023, Cells, 12, 10, 1422. A1 Journal article (refereed), original research -
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models
Wittrahm, Rebekka; Takalo, Mari; Kuulasmaa, Teemu; Mäkinen, Petra M; Mäkinen, Petri; Končarević, Saša; Fartzdinov, Vadim; Selzer, Stefan; Kokkola, Tarja; Antikainen, Leila; Martiskainen, Henna; Kemppainen, Susanna; Marttinen, Mikael; Jeskanen, Heli; Rostalski, Hannah; Rahunen, Eija; Kivipelto, Miia; Ngandu, Tiia; Natunen, Teemu; Lambert, Jean-Charles; Tanzi, Rudolph E; Kim, Doo Yeon; Rauramaa, Tuomas; Herukka, Sanna-Kaisa; Soininen, Hilkka; Laakso, Markku; Pike, Ian; Leinonen, Ville; Haapasalo,, 2023, Neurobiology of disease, 182, 106140. A1 Journal article (refereed), original research -
Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut
Martiskainen, Henna; Takalo, Mari; Konttinen, Henna; Malm, Tarja; Haapasalo, Annakaisa; Leinonen, Ville; Hiltunen, Mikko, 2021, Duodecim, 137, 13, 1375- 1382. A2 Review article, Literature review, Systematic review -
C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction
Huber, Nadine; Hoffmann, Dorit; Giniatullina, Raisa; Rostalski, Hannah; Leskelä, Stina; Takalo, Mari; Natunen, Teemu; Solje, Eino; Remes, Anne M.; Giniatullin, Rashid; Hiltunen, Mikko; Haapasalo, Annakaisa, 2021, Neurobiology of disease, 2022; 162, 105584. A1 Journal article (refereed), original research -
Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells
Leskelä, Stina; Huber, Nadine; Hoffmann, Dorit; Rostalski, Hannah; Remes, Anne M; Takalo, Mari; Hiltunen, Mikko; Haapasalo, Annakaisa, 2021, Biochimica et biophysica acta: molecular cell research, 1868, 7, 119021. A1 Journal article (refereed), original research -
MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation
Wittrahm, Rebekka; Takalo, Mari; Marttinen, Mikael; Kuulasmaa, Teemu; Mäkinen, Petra; Kemppainen, Susanna; Martiskainen, Henna; Rauramaa, Tuomas; Pike, Ian; Leinonen, Ville; Natunen, Teemu; Haapasalo, Annakaisa; Hiltunen, Mikko, 2021, Cells, 10, 4, 860. A1 Journal article (refereed), original research