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Marja A. Rytkönen-Nissinen

Marja A. Rytkönen-Nissinen

University Lecturer

university lecturer; subject: clinical microbiology

Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences

marja.rytkonen-nissinen@uef.fi | +358 40 355 2709

Information Publications

Research groups

Translational immunology group 01.01.2012 -

Publications

51/51 items

Single-cell characterization of dog allergen–specific T cells reveals TH2 heterogeneity in allergic individuals
Vandamme, C; Rytkönen-Nissinen, M; Lönnberg, T; Randell, J; Harvima RJ; Kinnunen, T; Virtanen, T. 2022. Journal of allergy and clinical immunology. 149: 1732-1743.e15
Characterization of Proinsulin T Cell Epitopes Restricted by Type 1 Diabetes-Associated HLA Class II Molecules
Ihantola, Emmi-Leena; Ilmonen, Henna; Kailaanmäki, Anssi; Rytkönen-Nissinen, Marja; Azam, Aurélien; Maillère, Bernard; Lindestam Arlehamn, Cecilia; Sette, Alessandro; Motwani, Keshav; Seay, Howard; Brusko, Todd; Knip, Mikael; Veijola, Riitta; Toppari, Jorma; Ilonen, Jorma; Kinnunen, Tuure. 2020. Journal of immunology. 204: 2349-2359
Mammalian Allergens
Virtanen, Tuomas; Rytkönen-Nissinen, Marja. Teoksessa: Lockey, Richard F; Ledford, Dennis K(toim.) , 2020. Allergens and Allergen Immunotherapy. Subcutaneous, Sublingual, and Oral. s. -. CRC press
Commentary: Allergen and Epitope Targets of Mouse-Specific T Cell Responses in Allergy and Asthma
Virtanen, Tuomas; Rytkönen-Nissinen, Marja. 2019. Frontiers in immunology. 10: 2266
Poistettujen hampaiden desinfektiomenetelmät
Kirvesniemi, Julia; Rytkönen-Nissinen, Marja; Karppinen, Minna; Lindqvist, Sirpa; Kumpulainen, Jonna; Kullaa, Arja. 2019. Suomen hammaslääkärilehti. 26: 34-38
Human memory CD4+ T cell response to the major dog allergen Can f 5, prostatic kallikrein
Kailaanmäki A, Kinnunen T, Rönkä A, Rytkönen-Nissinen M, Lidholm J,Mattsson L, Randell J, Virtanen T. 2016. Clinical and experimental allergy. 46: 720-729
Characterization of human memory CD4+ T-cell responses to the dog allergen Can f 4
Rönkä Aino L, Kinnunen Tuure T, Goudet Amélie, Rytkönen-Nissinen Marja A, Sairanen Joni, Kailaanmäki Anssi HT, Randell Jukka T, Maillére Bernard, Virtanen Tuomas I. 2015. Journal of allergy and clinical immunology. 136: 1047-1054.e10
Dimerization of lipocalin allergens
Niemi Merja H, Rytkönen-Nissinen Marja, Miettinen Ilja, Jänis Janne, Virtanen Tuomas, Rouvinen Juha. 2015. Scientific reports. 5: 13841
IgE Reactivity of the Dog Lipocalin Allergen Can f 4 and the Development of a Sandwich ELISA for Its Quantification
Rytkönen-Nissinen Marja, Saarelainen Soili, Randell Jukka, Häyrinen Jukka, Kalkkinen Nisse, Virtanen Tuomas. 2015. Allergy asthma & immunology research. 7: 384-392
Human CD4+ T Cell Responses to the Dog Major Allergen Can f 1 and Its human Homologue Tear Lipocalin Resemble Each Other
Liukko Aino LK, Kinnunen Tuure T, Rytkönen-Nissinen Marja A, Kailaanmäki Anssi HT, Randell Jukka T, Maillére Bernard, Virtanen Tuomas I. 2014. PLoS ONE. 9: 1-11
Mammalian Allergens
Virtanen Tuomas, Kinnunen Tuure, Rytkönen-Nissinen Marja. Teoksessa: Richard F. Lockey, Dennis K. Ledford(toim.) , 2014. Allergens and Allergen Immunotherapy subcutaneous, sublingual and oral. s. 217-234. CRC press
Structural aspects of dog allergies: The crystal structure of a dog dander allergen Can f 4
Niemi Merja H, Rytkönen-Nissinen Marja, Jänis Janne, Virtanen Tuomas, Rouvinen Juha. 2014. Molecular immunology. 61: 7-15
Differential CD4+ T-cell responses of allergic and non-allergic subjects to the immunodominant epitope region of the horse major allergen Equ c 1
Kailaanmäki Anssi, Kinnunen Tuure, Kwok William W, Rytkönen-Nissinen Marja, Randell Jukka, Virtanen Tuomas. 2013. Immunology. 141: 52-60
Mammal-Derived Respiratory Lipocalin Allergens do not Exhibit Dendritic Cell-Activating Capacity
Parviainen S, Kinnunen T, Rytkönen-Nissinen M, Nieminen A, Liukko A, Virtanen T. 2013. Scandinavian journal of immunology. 77: 171-176
Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen
Kauppinen Anu, Peräsaari Juha, Taivainen Antti, Kinnunen Tuure, Saarelainen Soili, Rytkönen-Nissinen Marja, Jeal Hayley, Jones Meinir, Virtanen Tuomas. 2012. Immunobiology. 217: 8-12
Mammalian lipocalin allergens--insights into their enigmatic allergenicity
Virtanen Tuomas, Kinnunen Tuure, Rytkönen-Nissinen Marja. 2012. Clinical and experimental allergy. 42: 494-504
Allergen-specific naïve and memory CD4+ T cells exhibit functional and phenotypic differences between individuals with or without allergy
Kinnunen T, Nieminen A, Kwok W W, Närvänen A, Rytkönen-Nissinen M, Saarelainen S, Taivainen A & Virtanen T.. 2010. European journal of immunology. 40: 2460-2469
Suboptimal recognition of a T cell epitope of the major dog allergen Can f 1 by human T cells
Juntunen R, Liukko A, Taivainen A, Närvänen A, Durand G, Kauppinen A, Nieminen A, Rytkönen-Nissinen M, Saarelainen S, Maillère B, Virtanen T, Kinnunen T. 2009. Molecular immunology. 46: 3320-3327
Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity
Saarelainen S, Rytkönen-Nissinen M, Rouvinen J, Taivainen A, Auriola S, Kauppinen A, Kinnunen T, Virtanen T. 2008. Clinical and experimental allergy. 38: 374-381
Immunotherapeutic potential of the immunodominant T-cell epitope of lipocalin allergen Bos d 2 and its analogues
Saarelainen SA, Kinnunen TT, Buhot C, Närvänen ATO, Kauppinen AK, Rytkönen-Nissinen MA, Maillere B, Virtanen TI. 2008. Immunology. 123: 358-366
Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy
Kinnunen T, Jutila K, Kwok WW, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Närvänen A, Taivainen A, Virtanen T. 2007. Journal of allergy and clinical immunology. 119: 965-972
Rakenteeltaan muunnellut peptidit avuksi allergian siedätyshoidossa
Kinnunen T, Jutila K, Kwok WW, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Närvänen A, Taivainen A, Virtanen T. 2007. Duodecim. 123: 775-776
The major horse allergen Equ c 1 contains one immunodominant region of T cell epitopes
Immonen A, Kinnunen T, Sirven P, Taivainen A, Houitte D, Peräsaari J, Närvänen A, Saarelainen S, Rytkönen- Nissinen M, Maillere B, Virtanen T. 2007. Clinical and experimental allergy. 37: 939-947
Use of multiple peptides containing T cell epitopes is a feasible approach for peptide-based immunotherapy in Can f 1 allergy
Immonnen AK, Taivainen AH, Närvänen ATO, Kinnunen TT, Saarelainen SA, Rytkönen-Nissinen MA, Virtanen TI. 2007. Immunology. 120: 38-46
Immunomodulatory potential of heteroclitic analogs of the dominant T-cell epitope of lipocalin allergen Bos d 2 on specific T cells
Kinnunen T, Kwock WW, Närvänen A, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Taivainen A, Virtanen T. 2005. International immunology. 17: 1573-1581
Psoriasin, a calcium-binding protein with chemotactic properties is present in the third trimester amniotic fluid
Porre S, Heinonen S, Mäntyjärvi R, Rytkönen-Nissinen M, Perola O, Rautiainen J, Virtanen T. 2005. Molecular human reproduction. 11: 87-92
T cell epitope-containing peptides of the major dog allergen can f 1 as candidates for allergen immunotherapy
Immonen A, Farci S, Taivainen A, Partanen J, Pouvelle-Moratille S, Närvänen A, Kinnunen T, Saarelainen S, Rytkönen-Nissinen M, Maillere B, Virtanen T. 2005. Journal of immunology. 175: 3614-3620
The DR4-DQ8 haplotype and a specific T cell receptor Vbeta T cell subset are associated with absence of allergy to Can f 1
Kinnunen T, Taivainen A, Partanen J, Immonen A, Saarelainen S, Rytkönen-Nissinen M, Rautiainen J, Virtanen T. 2005. Clinical and experimental allergy. 35: 797-803
Assessment of recombinant dog allergens Can f 1 and Can f 2 for the diagnosis of dog allergy
Saarelainen S, Taivainen A, Rytkönen-Nissinen M, Auriola S, Immonen A, Mäntyjärvi R, Rautiainen J, Kinnunen T, Virtanen T. 2004. Clinical and experimental allergy. 34: 1576-1582
Probing the mechanisms of low immunogenicity of a lipocalin allergen, Bos d 2, in a mouse model
Immonen A, Saarelainen S, Rautiainen J, Rytkönen-Nissinen M, Kinnunen T, Mäntyjärvi R, Virtanen T. 2003. Clinical and experimental allergy. 33: 834-841
The immunodominant epitope of lipocalin allergen Bos d 2 is suboptimal for human T cells
Kinnunen T, Buhot C, Närvänen A, Rytkönen-Nissinen M, Saarelainen S, Pouvelle-Moratille S, Rautiainen J, Taivainen A, Maillere B, Mäntyjärvi R, Virtanen T. 2003. European journal of immunology. 33: 1717-1726
Lipocalin allergen Bos d 2 is a weak immunogen
Saarelainen S, Zeiler T, Rautiainen J, Närvänen A, Rytkönen-Nissinen M, Mäntyjärvi R, Vilja P, Virtanen T. 2002. International immunology. 14: 401-409
Threshold levels of purified natural Bos d 2 for inducing bronchial airway response in asthmatic patients
Zeiler T, Taivainen A, Mäntyjärvi R, Tukiainen H, Rautiainen J, Rytkönen-Nissinen M, Virtanen T. 2002. Clinical and experimental allergy. 32: 1454-1460
In vitro and in vivo responses to the recombinant bovine dander allergen Bos d 2 and its fragments
Ruoppi P, Virtanen T, Zeiler T, Rytkönen-Nissinen M, Rautiainen J, Nuutinen J, Taivainen A. 2001. Clinical and experimental allergy. 31: 915-919
Early activation of TCR alpha gene rearrangement in fetal thymocytes
Rytkönen-Nissinen M, Hurwitz JL, Pelkonen S, Levelt C, Pelkonen J. 1999. European journal of immunology. 29: 2288-2296
Mutant derivatives of the main respiratory allergen of cow are less allergenic than the intact molecule
Kauppinen J, Zeiler T, Rautiainen J, Rytkönen-Nissinen M, Taivainen A, Mäntyjärvi R, Virtanen T. 1999. Clinical and experimental allergy. 29: 989-996
T cell epitopes of a lipocalin allergen colocalize with the conserved regions of the molecule
Zeiler T, Mäntyjärvi R, Rautiainen J, Rytkönen-Nissinen M, Vilja P, Taivainen A, Kauppinen J, Virtanen T. 1999. Journal of immunology. 162: 1415-1422
A bovine dander allergen, comparative modeling, and similarities and differences in folding with related proteins
Santa H, Saarela JTA, Laatikainen R, Rautiainen J, Virtanen T, Rytkönen M, Mäntyjärvi R. 1998. Protein journal. 17: 657-662
BDA20, a major bovine dander allergen characterized at the sequence level, is Bos d 2
Rautiainen J, Rytkönen M, Virtanen T, Pentikäinen J, Zeiler T, Mäntyjärvi R. 1997. Journal of allergy and clinical immunology. 100: 251-252
Clinical aspects of allergic disease. Recombinant allergen fragments as candidate preparations for allergen immunotherapy
Zeiler T, Taivainen A, Rytkönen M, Rautiainen J, Karjalainen H, Mäntyjärvi R, Tuomisto L, Virtanen T. 1997. Journal of allergy and clinical immunology. 100: 721-727
Recombinant allergen fragments as candidate preparations for allergen immunotherapy
Zeiler T, Taivainen A, Rytkönen M, Rautiainen J, Karjalainen H, Mäntyjärvi R, Tuomisto L, Virtanen T. 1997. Journal of allergy and clinical immunology. 100: 721-727
Complementary DNA cloning of the predominant allergen of bovine dander: A new member in the lipocalin family
Mäntyjärvi R, Parkkinen S, Rytkönen M, Pentikäinen J, Pelkonen J, Rautiainen J, Zeiler T, Virtanen T. 1996. Journal of allergy and clinical immunology. 97: 1297-1303
Immune reactivity of cow-asthmatic dairy farmers to the major allergen of cow (BDA20) and to other cow-derived proteins. The use of purified BDA20 increases the performance of diagnostic tests in respiratory cow allergy
Virtanen T, Zeiler T, Rautiainen J, Taivainen A, Pentikäinen J, Rytkönen M, Parkkinen S, Pelkonen J, Mäntyjärvi R. 1996. Clinical and experimental allergy. 26: 188-196
Molecular analysis of allergenic proteins in bovine dander
Rautiainen J, Pentikäinen J, Rytkönen M, Linnala-Kankkunen A, Pelkonen J, Virtanen T, Mäntyjärvi R. 1996. Allergy. 51: 378-382
Restricted onset of T cell receptor alfa gene rearrangement in fetal and neonatal thymocytes
Rytkönen MA, Hurwitz JL, Thompson SD, Pelkonen J. 1996. European journal of immunology. 26: 1892-1896
T-cell Receptor Alpha and Delta Gene Rearrangements in the Regulation of T-cell Development
Rytkönen M. 1996. Kuopio University Publications D. Medical Sciences
Homology of a bovine allergen and the oligomycin sensitivity-conferring protein of the mitochondrial adenosine triphosphate synthase complex
Parkkinen S, Rytkönen M, Pentikäinen J, Virtanen T, Mäntyjärvi R. 1995. Journal of allergy and clinical immunology. 95: 1255-1260
cDNA cloning and molecular characterization of bovine dander allergens
Mäntyjärvi RA, Parkkinen S, Rytkönen M, Pentikäinen J, Pelkonen J, Rautiainen J, Zeiler T, Virtanen T. Teoksessa: Basomba A, Hernandez F. de Rojas(toim.) , 1995. XVI European Congress of Allergology and Clinical Immunnlogy ECACI 95. s. 111-115. Monduzzi
cDNA cloning and protein analysis of a bovine dermal allergen with homology to psoriasin
Rautiainen J, Rytkönen M, Parkkinen S, Pentikäinen J, Linnala-Kankkunen A, Virtanen T, Pelkonen J, Mäntyjärvi R. 1995. Journal of investigative dermatology. 105: 660-663
Evidence for recombinatorial hot spots at the T cell receptor Jalpha locus
Rytkönen MA, Hurwitz J L.,Tolonen K & Pelkonen J. 1994. European journal of immunology. 24: 107-115
Non-random rearrangement of T-cell receptor J-alpha genes in bone marrow T-differentation cultures
Thompson SD, Pelkonen J, Rytkönen M, Samaridis J, Hurwitz JL. 1990. Journal of immunology. 144: 2829-2834

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Marja A. Rytkönen-Nissinen

Research groups

Single-cell characterization of dog allergen–specific T cells reveals TH2 heterogeneity in allergic individuals

Characterization of Proinsulin T Cell Epitopes Restricted by Type 1 Diabetes-Associated HLA Class II Molecules

Mammalian Allergens

Commentary: Allergen and Epitope Targets of Mouse-Specific T Cell Responses in Allergy and Asthma

Poistettujen hampaiden desinfektiomenetelmät

Human memory CD4+ T cell response to the major dog allergen Can f 5, prostatic kallikrein

Characterization of human memory CD4+ T-cell responses to the dog allergen Can f 4

Dimerization of lipocalin allergens

IgE Reactivity of the Dog Lipocalin Allergen Can f 4 and the Development of a Sandwich ELISA for Its Quantification

Human CD4+ T Cell Responses to the Dog Major Allergen Can f 1 and Its human Homologue Tear Lipocalin Resemble Each Other

Mammalian Allergens

Structural aspects of dog allergies: The crystal structure of a dog dander allergen Can f 4

Differential CD4+ T-cell responses of allergic and non-allergic subjects to the immunodominant epitope region of the horse major allergen Equ c 1

Mammal-Derived Respiratory Lipocalin Allergens do not Exhibit Dendritic Cell-Activating Capacity

Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen

Mammalian lipocalin allergens--insights into their enigmatic allergenicity

Allergen-specific naïve and memory CD4+ T cells exhibit functional and phenotypic differences between individuals with or without allergy

Suboptimal recognition of a T cell epitope of the major dog allergen Can f 1 by human T cells

Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity

Immunotherapeutic potential of the immunodominant T-cell epitope of lipocalin allergen Bos d 2 and its analogues

Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy

Rakenteeltaan muunnellut peptidit avuksi allergian siedätyshoidossa

The major horse allergen Equ c 1 contains one immunodominant region of T cell epitopes

Use of multiple peptides containing T cell epitopes is a feasible approach for peptide-based immunotherapy in Can f 1 allergy

Immunomodulatory potential of heteroclitic analogs of the dominant T-cell epitope of lipocalin allergen Bos d 2 on specific T cells

Psoriasin, a calcium-binding protein with chemotactic properties is present in the third trimester amniotic fluid

T cell epitope-containing peptides of the major dog allergen can f 1 as candidates for allergen immunotherapy

The DR4-DQ8 haplotype and a specific T cell receptor Vbeta T cell subset are associated with absence of allergy to Can f 1

Assessment of recombinant dog allergens Can f 1 and Can f 2 for the diagnosis of dog allergy

Probing the mechanisms of low immunogenicity of a lipocalin allergen, Bos d 2, in a mouse model

The immunodominant epitope of lipocalin allergen Bos d 2 is suboptimal for human T cells

Lipocalin allergen Bos d 2 is a weak immunogen

Threshold levels of purified natural Bos d 2 for inducing bronchial airway response in asthmatic patients

In vitro and in vivo responses to the recombinant bovine dander allergen Bos d 2 and its fragments

Early activation of TCR alpha gene rearrangement in fetal thymocytes

Mutant derivatives of the main respiratory allergen of cow are less allergenic than the intact molecule

T cell epitopes of a lipocalin allergen colocalize with the conserved regions of the molecule

A bovine dander allergen, comparative modeling, and similarities and differences in folding with related proteins

BDA20, a major bovine dander allergen characterized at the sequence level, is Bos d 2

Clinical aspects of allergic disease. Recombinant allergen fragments as candidate preparations for allergen immunotherapy

Recombinant allergen fragments as candidate preparations for allergen immunotherapy

Complementary DNA cloning of the predominant allergen of bovine dander: A new member in the lipocalin family

Immune reactivity of cow-asthmatic dairy farmers to the major allergen of cow (BDA20) and to other cow-derived proteins. The use of purified BDA20 increases the performance of diagnostic tests in respiratory cow allergy

Molecular analysis of allergenic proteins in bovine dander

Restricted onset of T cell receptor alfa gene rearrangement in fetal and neonatal thymocytes

T-cell Receptor Alpha and Delta Gene Rearrangements in the Regulation of T-cell Development

Homology of a bovine allergen and the oligomycin sensitivity-conferring protein of the mitochondrial adenosine triphosphate synthase complex

cDNA cloning and molecular characterization of bovine dander allergens

cDNA cloning and protein analysis of a bovine dermal allergen with homology to psoriasin

Evidence for recombinatorial hot spots at the T cell receptor Jalpha locus

Non-random rearrangement of T-cell receptor J-alpha genes in bone marrow T-differentation cultures