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Marjut Roponen

Marjut Roponen

Professor

Toxicology of environmental exposures

Faculty of Science, Forestry and Technology, Department of Environmental and Biological Sciences

marjut.roponen@uef.fi | +358 40 356 2521

Information Publications

My research focuses on the early-life environmental exposure, immune development and the risk of allergic diseases. I also study how climate change affects pollen allergenicity factors and the prevalence of allergic diseases in Finland. I have specialized in immunotoxicology and -epidemiology.

Research groups

Inhalation Toxicology Laboratory 01.01.2010 -

Keywords

air pollution childhood asthma environmental exposure environmental health immunology immunotoxicology inhalation toxicology

Publications

78 items

Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers
Illi, S; Depner, M; Pfefferle, PI; Renz, H; Roduit, C; Taft, DH; Kalanetra, KM; Mills, DA; Farquharson, FM; Louis, P; Schmausser-Hechfellner, E; Divaret-Chauveau, A; Lauener, R; Karvonen, AM; Pekkanen, J; Kirjavainen, PV; Roponen, M; Riedler, J; Kabesch, M; Schaub, B; von Mutius, E; PASTURE Study Group. American journal of respiratory and critical care medicine [in press]: -. 2022
Short-Term Effects of Particle Sizes and Constituents on Blood Biomarkers among Healthy Young Adults in Guangzhou, China
Feng, Dan; Cao, Ke; He, Zhi-Zhou; Knibbs, Luke D.; Jalaludin, Bin; Leskinen, Ari; Roponen, Marjut; Komppula, Mika; Jalava, Pasi; Guo, Peng-Yue; Xu, Shu-Li; Yang, Bo-Yi; Hu, Liwen; Zeng, Xiao-Wen; Chen, Gongbo; Yu, Hong-Yao; Lin, Lizi; Dong, Guanghui. Environmental science and technology 55 9: 9. 2021
Short-Term Effects of Particle Size and Constituents on Blood Pressure in Healthy Young Adults in Guangzhou, China
Guo, Peng-Yue; He, Zhi-Zhou; Jalaludin, Bin; Knibbs, Luke D; Leskinen, Ari; Roponen, Marjut; Komppula, Mika; Jalava, Pasi; Hu, Li-Wen; Chen, Gongbo; Zeng, Xiao-Wen; Yang, Bo-Yi; Dong, Guang-Hui. Journal of the American heart association 10 10: e019063. 2021
Associations of Particulate Matter Sizes and Chemical Constituents with Blood Lipids: A Panel Study in Guangzhou, China
He, Zhi-Zhou; Guo, Peng-Yue; Xu, Shu-Li; Zhou, Yang; Jalaludin, Bin; Leskinen, Ari; Knibbs, Luke D; Heinrich, Joachim; Morawska, Lidia; Yim, Steve Hung-Lam; Bui, Dinh; Komppula, Mika; Roponen, Marjut; Hu, Liwen; Chen, Gongbo; Zeng, Xiao-Wen; Yu, Yunjiang; Yang, Bo-Yi; Dong, Guanghui. Environmental science and technology 55 8: 5065-5075. 2021
Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles
Liu, Lizhi; Bai, Xuan; Martikainen, Maria-Viola; Kårlund, Anna; Roponen, Marjut; Xu, Wujun; Hu, Guoqing; Tasciotti, Ennio; Lehto, Vesa-Pekka. Nature communications 12 1: 5726. 2021
Toxicological and microbiological characterization of cow stable dust
Martikainen, Maria-Viola; Tossavainen, Tarleena; Täubel, Martin; Wolczkiewicz, Kirsi; Lähde, Anna; Roponen, Marjut. Toxicology in vitro 75: 105202. 2021
Mitogen-activated protein kinase signaling in childhood asthma development and environment-mediated protection
Theodorou, J; Nowak, E; Böck, A; Salvermoser, M; Beerweiler, C; Zeber, K; Kulig, P; Tsang, MS; Wong, CK; Wong, GWK; Roponen, M; Kumbrink, J; Alhamdan, F; Michel, F; Garn, H; Tosevski, V; Schaub, B. Pediatric allergy and immunology 2022; 33 1: e13657. 2021
Early age exposure to moisture and mould is related to FeNO at the age of 6 years
Tischer, Christina; Karvonen, Anne M; Kirjavainen, Pirkka V; Flexeder, Claudia; Roponen, Marjut; Hyvärinen, Anne; Renz, Harald; Frey, Urs Peter; Fuchs, Oliver; Pekkanen, Juha. Pediatric allergy and immunology 32 6: 1226-1237. 2021
Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma
Depner, Martin; Taft, Diana Hazard; Kirjavainen, Pirkka V; Kalanetra, Karen M; Karvonen, Anne M; Peschel, Stefanie; Schmausser-Hechfellner, Elisabeth; Roduit, Caroline; Frei, Remo; Lauener, Roger; Divaret-Chauveau, Amandine; Dalphin, Jean-Charles; Riedler, Josef; Roponen, Marjut; Kabesch, Michael; Renz, Harald; Pekkanen, Juha; Farquharson, Freda M; Louis, Petra; Mills, David A. et al.. Nature medicine 26: 1766-1775. 2020
Thermal dose as a universal tool to evaluate nanoparticle-induced photothermal therapy
Happonen, Emilia; Tamarov, Konstantin; Martikainen, Maria-Viola; Ketola, Kirsi; Roponen, Marjut; Lehto, Vesa-Pekka; Xu, Wujun. International journal of pharmaceutics 587: 119657. 2020
Cryopreservation Affected the Levels of Immune Responses of PBMCs and Antigen-Presenting Cells
Martikainen, Maria-Viola; Roponen, Marjut. Toxicology in vitro 67: 104918. 2020
Urban air PM modifies differently immune defense responses against bacterial and viral infections in vitro
Shahbaz, Muhammad Ali; Martikainen, Maria-Viola; Rönkkö, Teemu J; Komppula, Mika; Jalava, Pasi I; Roponen, Marjut. Environmental research 192: 110244. 2020
Association Between Residential Greenness, Cardiometabolic Disorders, and Cardiovascular Disease Among Adults in China
Yang, Bo-Yi; Hu, Li-Wen; Jalaludin, Bin; Knibbs, Luke D; Markevych, Iana; Heinrich, Joachim; Bloom, Michael S; Morawska, Lidia; Lin, Shao; Jalava, Pasi; Roponen, Marjut; Gao, Meng; Chen, Duo-Hong; Zhou, Yang; Yu, Hong-Yao; Liu, Ru-Qing; Zeng, Xiao-Wen; Zeeshan, Mohammed; Guo, Yuming; Yu, Yunjiang et al.. JAMA network open 3 9: e2017507. 2020
Is PM 1 similar to PM 2.5? A new insight into the association of PM 1 and PM 2.5 with children's lung function
Yang, Mo; Guo, Yu-Ming; Bloom, Michael S; Dharmagee, Shyamali C; Morawska, Lidia; Heinrich, Joachim; Jalaludin, Bin; Markevychd, Iana; Knibbsf, Luke D; Lin, Shao; Hung Lan, Steve; Jalava, Pasi; Komppula, Mika; Roponen, Marjut; Hirvonen, Maija-Riitta; Guan, Qi-Hua; Liang, Zi-Mian; Yu, Hong-Yao; Hu, Li-Wen; Yang, Bo-Yi; et al.. Environment international 145: 106092. 2020
Modification of caesarean section on the associations between air pollution and childhood asthma in seven Chinese cities
Yu, Hongyao; Guo, Yuming; Zeng, Xiaoyun; Gao, Meng; Yang, Bo-Yi; Hu, Li-Wen; Yu, Yunjiang; Dong, Guang-Hui; Zhou, Yang; Qian, Zhengmin; Sun, Jia; McMillin, Stephen Edward; Bloom, Michael S; Heinrich, Joachim; Markevych, Iana; Morawska, Lidia; Dharmage, Shyamali C; Jalaludin, Bin; Knibbs, Luke; Lin, Shao; et al. [incl. Jalava, Pasi; Roponen, Marjut; Leskinen, Ari]. Environmental pollution 267: 115443. 2020
Greenness surrounding schools is associated with lower risk of asthma in schoolchildren.
Zeng, Xiao-Wen; Lowe, Adrian J; Lodge, Caroline J; Heinrich, Joachim; Roponen, Marjut; Jalava, Pasi; Guo, Yuming; Hu, Li-Wen; Yang, Bo-Yi; Dharmage, Shyamali C; Dong, Guang-Hui. Environment international 143: 105967. 2020
Parents know it best: Prediction of asthma and lung function by parental perception of early wheezing episodes
Brick, Tabea; Hose, Alexander; Wawretzka, Katharina; von Mutius, Erika; Roduit, Caroline; Lauener, Roger; Riedler, Josef; Karvonen, Anne M; Pekkanen, Juha; Divaret-Chauveau, Amandine; Dalphin, Jean-Charles; Ege, Markus J; PASTURE study group (incl. Roponen, Marjut; Hirvonen, Maija-Riitta; Kirjavainen, Pirkka Viljami). Pediatric allergy and immunology 30 8: 795-802. 2019
Farm-like indoor microbiota in non-farm homes protects children from asthma development
Kirjavainen, PV; Karvonen, AM; Adams, RI; Täubel, M; Roponen, M; Tuoresmäki, P; Loss, G; Jayaprakash, B; Depner, M; Ege, MJ; Renz, H; Pfefferle, PI; Schaub, B; Lauener, R; Hyvärinen, A; Knight, R; Heederik, DJJ; von Mutius, E; Pekkanen, J. Nature medicine 25: 1089-1095. 2019
Maatalomainen kodin mikrobisto voi suojata astmalta kaupungissakin
Kirjavainen, PV; Karvonen, AM; Adams, RI; Täubel, M; Roponen, M; Tuoresmäki, P; Loss, G; Jayaprakash, B; Depner, M; Ege, MJ; Renz, H; Pfefferle, PI; Schaub, B; Lauener, R; Hyvärinen, A; Knight, R; Heederik, DJJ; von Mutius, E; Pekkanen, J. Duodecim 135 13: 1309. 2019
TNF-α-induced protein 3 is a key player in childhood asthma development and environment-mediated protection
Krusche, Johanna; Twardziok, Monika; Rehbach, Katharina; Böck, Andreas; Tsang, Miranda S; Schröder, Paul C; Kumbrink, Jörg; Kirchner, Thomas; Xing, Yuhan; Riedler, Josef; Dalphin, Jean-Charles; Pekkanen, Juha; Lauener, Roger; Roponen, Marjut; Li, Jing; Wong, Chun K; Wong, Gary W K; Schaub, Bianca; Ege, Markus; Depner, Martin; et al.. Journal of allergy and clinical immunology 144 6: 1684-1696.e12. 2019
Benefits of influenza vaccination on the associations between ambient air pollution and allergic respiratory diseases in children and adolescents: New insights from the Seven Northeastern Cities study in China
Liu, Kangkang; Li, Shanshan; Qian, Zhengmin (Min); Dharmage, Shyamali C; Bloom, Michael S; Heinrich, Joachim; Jalaludin, Bin; Markevych, Iana; Morawska, Lidia; Knibbs, Luke D; Hinyard, Leslie; Xian, Hong; Liu, Shan; Lin, Shao; Leskinen, Ari; Komppula, Mika; Jalava, Pasi; Roponen, Marjut; Hu, Li-Wen; Zeng, Xiao-Wen; et al.. Environmental pollution 2020; 256: 113434. 2019
Association between antibiotic treatment during pregnancy & infancy and the development of allergic diseases
Metzler, S; Frei, R; Schmaußer-Hechfellner, E; von Mutius, E; Pekkanen, J; Karvonen, AM; Kirjavainen, PV; Dalphin, JC; Divaret-Chauveau, A; Riedler, J; Lauener, R; Roduit, C; PASTURE/EFRAIM study group (incl. Roponen, Marjut). Pediatric allergy and immunology 30 4: 423-433. 2019
Ambient Airborne Particulates of Diameter less than or equal to 1 micrometre, a Leading Contributor to the Association Between Ambient Airborne Particulates of Diameter less than or equal to 2.5 micrometres and Children's Blood Pressure
Wu, QZ; Li, S; Yang, BY; Bloom, M; Shi, Z; Knibbs, L; Dharmage, S; Leskinen, A; Jalaludin, B; Jalava, P; Roponen, M; Lin, S; Chen, G; Guo, Y; Xu, SL; Yu, HY; Zeeshan, M; Hu, LW; Yu, Y; Zeng, XW; et al.. Hypertension 2020; 75 2: 347-355. 2019
Greenness around schools associated with lower risk of hypertension among children: Findings from the Seven Northeastern Cities Study in China
Xiao, Xiang; Yang, Bo-Yi; Markevych, Iana; Bloom, Michael S; Dharmage, Shyamali C; Jalaludin, Bin; Knibbs, Luke D; Heinrich, Joachim; Morawska, Lidia; Lin, Shao; Roponen, Marjut; Guo, Yuming; Hung Lam Yim, Steve; Leskinen, Ari; Komppula, Mika; Jalava, Pasi; Yu, Hong-Yao; Zeeshan, Mohammed; Zeng, Xiao-Wen; Dong, Guang-Hui. Environmental pollution 2020; 256: 113422. 2019
Prenatal exposure to perfluoroalkyl substances is associated with lower hand, foot and mouth disease viruses antibody response in infancy: Findings from the Guangzhou Birth Cohort Study
Zeng, XW; Bloom, MS; Dharmage, SC; Lodge, CJ; Chen, D; Li, S; Guo, Y; Roponen, M; Jalava, P; Hirvonen, MR; Ma, H; Hao, YT; Chen, W; Yang, M; Chu, C; Li, QQ; Hu, LW; Liu, KK; Yang, BY; Liu, S; et al. Science of the total environment 663: 60-67. 2019
Association of Breastfeeding and Air Pollution Exposure With Lung Function in Chinese Children
Zhang, C; Guo, Y; Xiao, X; Bloom, MS; Qian, Z; Rolling, CA; Xian, H; Lin, S; Li, S; Chen, G; Jalava, P; Roponen, M; Hirvonen, MR; Komppula, M; Leskinen, A; Yim, SHL; Chen, DH; Ma, H; Zeng, XW; Hu, LW; et al.. JAMA network open 2 5: e194186. 2019
Protective effects of breastfeeding on respiratory symptoms in infants with 17q21 asthma risk variants
Gorlanova, O; Illi, S; Toncheva, AA; Usemann, J; Latzin, P; Kabesch, M; Dalphin, JC; Lauener, R; Pekkanen, JR; Von Mutius, E; Riedler, J; Kuehni, CE; Röösli, M; Frey, U; et al.; BILD and PASTURE study groups (incl. Roponen, M). ALLERGY 73 12: 2388-2392. 2018
A panel study of airborne particulate matter concentration and impaired cardiopulmonary function in young adults by two different exposure measurement
Hu, Li-Wen; Qian, Zhengmin (Min); Bloom, Michael S; Nelson, Erik J; Liu, Echu; Han, Bin; Zhang, Nan; Liu, Yimin; Ma, Huimin; Chen, Duo-Hong; Yang, Bo-Yi; Zeng, Xiao-Wen; Chen, Wen; Komppula, Mika; Leskinen, Ari; Hirvonen, Maija-Riitta; Roponen, Marjut; Jalava, Pasi; Bai, Zhipeng; Dong, Guang-Hui. Atmospheric Environment 180: 103-109. 2018
Early age exposure to moisture damage and systemic inflammation at the age of 6 years
Karvonen, AM; Tischer, C; Kirjavainen, PV; Roponen, M; Hyvärinen, A; Illi, S; Mustonen, K; Pfefferle, PI; Renz, H; Remes, S; Schaub, B; von Mutius, E; Pekkanen, J. INDOOR AIR 28 3: 450-458. 2018
Integrating farm and air pollution studies in search for immunoregulatory mechanisms operating in protective and high-risk environments
Martikainen, MV; Rönkkö, TJ; Schaub, B; Täubel, M; Gu, C; Wong, GW; Li, J; Pekkanen, J; Komppula, M; Hirvonen, MR; Jalava, PI; Roponen, M. PEDIATRIC ALLERGY AND IMMUNOLOGY 29 8: 815-822. 2018
High levels of Butyrate and Propionate in early life are associated with protection against atopy
Roduit, C; Frei, R; Ferstl, R; Loeliger, S; Westermann, P; Rhyner, C; Schiavi, E; Barcik, W; Rodriguez-Perez, N; Wawrzyniak, M; Chassard, C; Lacroix, C; Schmausser-Hechfellner, E; Depner, M; von Mutius, E; Braun-Fahrländer, C; Karvonen, A; Kirjavainen, P; Pekkanen, J; Dalphin, JC; et al. Allergy 2019; 74 4: 799-809. 2018
Is smaller worse? New insights about associations of PM1 and respiratory health in children and adolescents
Yang, M; Chu, C; Bloom, MS; Li, S; Chen, G; Heinrich, J; Markevych, I; Knibbs, LD; Bowatte, G; Dharmage, SC; Komppula, M; Leskinen, A; Hirvonen, MR; Roponen, M; Jalava, P; Wang, SQ; Lin, S; Zeng, XW; Hu, LW; Liu, KK; et al.. Environment international 120: 516-524. 2018
Functional phenotypes determined by fluctuation-based clustering of lung function measurements in healthy and asthmatic cohort participants
Delgado-Eckert E, Fuchs O, Kumar N, Pekkanen J, Dalphin JC, Riedler J, Lauener R, Kabesch M, Kupczyk M, Dahlen SE, Mutius EV, Frey U et al., PASTURE Study group, BIOAIR Study group. THORAX 2018; 73 2: 107-115. 2017
Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis
Frei Remo, Ferstl Ruth, Roduit Caroline, Ziegler Mario, Schiavi Elisa, Barcik Weronika, Rodriguez-Perez Noelia, Wirz Oliver F, Wawrzyniak Marcin, Pugin Benoit, Nehrbass Dirk, Jutel Marek, Smolinska Sylwia, Konieczna Patrycja, Bieli Christian, Loeliger Susanne, Waser Marco, Pershagen Göran, Riedler Josef, Depner Martin et al. (incl. Roponen Marjut, Hirvonen Marja-Riitta, Pekkanen Juha). JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2018; 141 1: 382-390.e7. 2017
Latent class analysis reveals clinically relevant atopy phenotypes in two birth cohorts
Hose AJ, Depner M, Illi S, Lau S, Keil T, Wahn U, Fuchs O, Pfefferle PI, Schmaußer-Hechfellner E, Genuneit J, Lauener R, Karvonen AM, Roduit C, Dalphin JC, Riedler J, Pekkanen J, von Mutius E, Ege MJ, Bauer CP, Forster J et al., MAS and PASTURE Study Grops. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 139 6: 1935-1945.e12-. 2017
The lack of natural processes of delivery and neonatal intensive care treatment lead to impaired cytokine responses later in life
Martikainen M-V, Keski-Nisula L, Jakupovic H, Karvonen AM, Pekkanen J, Hirvonen M-R, Roponen M. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (NEW YORK) 77 3: -. 2017
Phenotypes of atopic dermatitis depending on the timing of onset and progression in childhood
Roduit C, Frei R, Depner M, Karvonen AM, Renz H, Braun-Fahrländer C, Schmausser-Hechfellner E, Pekkanen J, Riedler J, Dalphin J-C, von Mutius E, Lauener RP and the PASTURE study group. JAMA Pediatrics 171 7: 655-662. 2017
Asthmatic farm children show increased CD3+CD8low T-cells compared to non-asthmatic farm children
Twardziok M, Schröder PC, Krusche J, Casaca VI, Illi S, Böck A, Loss GJ, Kabesch M, Toncheva A, Roduit C, Depner M, Genuneit J, Renz H, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Lauener R, Vuitton DA, Dalphin JC et al., the PASTURE Study Group. Clinical Immunology 183: 285-292. 2017
Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children
Zhou Y, Hu LW, Qian Z, Geiger SD, Parrish KL, Dharmage SC, Campbell B, Roponen M, Jalava P, Hirvonen MR, Heinrich J, Zeng XW, Yang BY, Qin XD, Lee YLL, Dong GH. Scientific Reports 7: 899. 2017
Enhanced T helper 1 and 2 cytokine responses at birth associate with lower risk of middle ear infections in infancy
Bergroth E, Roponen M, Karvonen AM, Keski-Nisula L, Remes S, Riedler J, Roduit C, Dalphin J-C, Kaulek V, Loss GJ, Lauener R, Hirvonen M-R, Genuneit J, Schmaußer-Hechfellner E, Renz H, Pfefferle PI, Krauss-Etschmann S, Schaub B, von Mutius E, Pekkanen J, the PASTURE study group. PEDIATRIC ALLERGY AND IMMUNOLOGY 2017; 28 1: 53-59. 2016
Associations of Early Life Exposures and Environmental Factors With Asthma Among Children in Rural and Urban Areas of Guangdong, China
Feng M, Yang Z, Pan L, Lai X, Xian M, Huang X, Chen Y, Schröder PC, Roponen M, Schaub B, Wong GW, Li J. CHEST 149 4: 1030-1041. 2016
Associations of natural history and environmental factors with asthma among children in rural and urban areas of Guangdong, China
Feng M, Yang Z, Pan L, Lai X, Xian M, Huang X, Chen Y, Schröder PC, Roponen M, Schaub B, Wong GWK, Li J. CHEST 149 4: 1030-1041. 2016
The Early Development of Wheeze: Environmental Determinants and Genetic Susceptibility at 17q21
Loss GJ, Depner M, Hose AJ, Genuneit J, Karvonen AM, Hyvärinen A, Roduit C, Kabesch M, Lauener R, Pfefferle PI, Pekkanen J, Dalphin JC, Riedler J, Braun-Fahrländer C, von Mutius E, Ege MJ, PASTURE study group (Dalphin M-L, Doekes G, Frei R, Hirvonen M-R, Illi S, Kaulek V, Schaub B, Remes S, Renz H, Roponen M, Tiittanen P). AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 193 8: 889-897. 2016
Maatila-altistuminen muokkaa lasten immuunivastetta sääteleviä mekanismeja
Martikainen Maria-Viola, Roponen Marjut. BestPractice Keuhkosairaudet: lääketieteen asiantuntijoiden ammattilehti 12: 22-23. 2016
IL-33 polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort
Schröder PC, Casaca VI, Illi S, Schieck M, Michel S, Böck A, Roduit C, Frei R, Lluis A, Genuneit J, Pfefferle P, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Lauener R, Vuitton DA, Dalphin J-C, Pekkanen J, von Mutius E et al.. PEDIATRIC ALLERGY AND IMMUNOLOGY 27 7: 687-695. 2016
A switch in regulatory T cells through farm-exposure during immune maturation in childhood
Schröder PC, Illi S, Casaca VI, Lluis A, Böck A, Roduit C, Depner M, Frei R, Genuneit J, Pfefferle PI, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Dalphin JC, Pekkanen J, Lauener R, von Mutius E, Schaub B, PASTURE study group (Hyvärinen A, Karvonen AM, Hirvonen MR, Tiittanen P, Remes S, Kaulek V, Dalphin ML, Ege MJ, Loss GJ, Renz H, Doekes G, Kabesch M). ALLERGY [Epub ahead of print 17 Nov 2016]: -. 2016
Exposure to a farm environment is associated with Th1 and regulatory cytokines at age 4.5 years
Kääriö H, Huttunen K, Karvonen AM, Schaub B, von Mutius E, Pekkanen J, Hirvonen MR, Roponen M. Clinical & Experimental Allergy 2016; 46 1: 71-77. 2015
Circulating dendritic cells, farm exposure and asthma at early age
Kääriö Heidi, Nieminen Janne K, Karvonen Anne M, Huttunen Kati, Schröder Paul C, Vaarala Outi, von Mutius Erika, Pfefferle Petra Ina, Schaub Bianca, Pekkanen Juha, Hirvonen Maija-Riitta, Roponen Marjut. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 83 (2016) 1: 18-25. 2015
Farm exposures are associated with lower percentage of circulating myeloid dendritic cell subtype 2 at age 6
Martikainen M-V, Kääriö H, Karvonen A Schröder PC, Renz H, Kaulek V, Dalphin J-C, von Mutius E, Schaub B, Pekkanen J, Hirvonen M-R, Roponen M. ALLERGY 70 10: 1278-1287. 2015
Moisture damage in home associates with systemic inflammation in children
Mustonen K, Karvonen AM, Kirjavainen P, Roponen M, Schaub B, Hyvärinen A, Frey U, Renz H, Pfefferle PI, Genuneit J, Vaarala O, Pekkanen J. INDOOR AIR [epub ahead of print 23 May 2015]: -. 2015
High level of fecal calprotectin at age 2 months as a marker of intestinal inflammation predicts atopic dermatitis and asthma by age 6
Orivuori L, Mustonen K, de Goffau MC, Hakala S, Paasela M, Roduit C, Dalphin JC, Genuneit J, Lauener R, Riedler J, Weber J, von Mutius E, Pekkanen J, Harmsen HJ, Vaarala O, PASTURE Study Group (Hirvonen MR, Hyvärinen A, Karvonen AM, Remes S, Roponen M, Tiittanen P, Dalphin ML, Kaulek V, Depner M, Ege M, Illi S, Kabesch M, Pfefferle P, Renz H, Schaub B, Doekes G, Braun-Fahrländer C, Frei R, Loss G). CLINICAL AND EXPERIMENTAL ALLERGY 45 5: 928-939. 2015
Clinical and Epidemiologic Phenotypes of Childhood Asthma
Depner Martin, Fuchs Oliver, Genuneit Jon, Karvonen Anne M, Hyvärinen Anne, Kaulek Vincent, Roduit Caroline, Weber Juliane, Schaub Bianca, Lauener Roger, Kabesch Michael, Pfefferle Petra Ina, Frey Urs, Pekkanen Juha, Dalphin Jean-Charles, Riedler Joseph, Braun-Fahrländer Charlotte, von Mutius Erika, Ege Markus J and the PASTURE Study Group. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 189 2: 129-138. 2014
The effect of assay type and sample matrix on detected cytokine concentrations in human blood serum and nasal lavage fluid
Huttunen Kati, Tiihonen Kati, Roponen Marjut, Heederik Dick, Zock Jan-Paul, Täubel Martin, Hyvärinen Anne, Hirvonen Maija-Riitta. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 96 -: 151-155. 2014
Determinants, reproducibility, and seasonal variation of bacterial cell wall components and viable counts in house dust
Leppänen HK, Täubel M, Roponen M, Vepsäläinen A, Rantakokko P, Pekkanen J, Nevalainen A, von Mutius E, Hyvärinen A.. INDOOR AIR 2015; 25 3: 260-272. 2014
Consumption of unprocessed cow's milk protects infants from common respiratory infections
Loss Georg, Depner Martin, Ulfman Laurien H, van Neerven RJ Joost, Hose Alexander J, Genuneit Jon, Karvonen Anne M, Hyvärinen Anne, Kaulek Vincent, Roduit Caroline, Weber Juliane, Lauener Roger, Pfefferle Petra Ina, Pekkanen Juha, Vaarala Outi, Dalphin Jean-Charles, Riedler Josef, Braun-Fahrländer Charlotte, von Mutius Erika, Ege Markus J. and the PASTURE study group. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 135 1: 56-62.E2. 2014
Immunoglobulin A and immunoglobulin G antibodies against ß-lactoglobulin and gliadin at age 1 associate with immunoglobulin E sensitization at age 6
Orivuori L, Loss G, Roduit C, Dalphin JC, Depner M, Genuneit J, Lauener R, Pekkanen J, Pfefferle P, Riedler J, Roponen M, Weber J, von Mutius E, Braun-Fahrländer C, Vaarala O, PASTURE Study Group (Hirvonen MR, Hyvärinen A, Karvonen AM, Remes S, Roponen M, Tiittanen P, Dalphin ML, Kaulek V, Büchele G, Depner M, Ege M, Kabesch M, Pfefferle P, Renz H, Schaub B, Doekes G, Frei R). PEDIATRIC ALLERGY AND IMMUNOLOGY 25 4: 329-337. 2014
Increased food diversity in the first year of life is inversely associated with allergic diseases
Roduit Caroline, Frei Remo, Depner Martin, Schaub Bianca, Loss Georg, Genuneit Jon, Pfefferle Petra, Hyvärinen Anne, Karvonen Anne M, Riedler Josef, Dalphin Jean-Charles, Pekkanen Juha, von Mutius Erika, Braun-Fahrländer Charlotte, Lauener Roger; PASTURE study group (Hirvonen Maija-Riitta, Remes Sami, Roponen Marjut, Tiittanen Petri, Dalphin Marie-Laure, Kaulek Vincent, Buchele Gisela, Ege Markus,. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 133 4: 1056-1064. 2014
Atopic sensitization in the first year of life
Depner M, Ege MJ, Genuneit J, Pekkanen J, Roponen M, Hirvonen MR, Dalphin JC, Kaulek V, Krauss-Etschmann S, Riedler J, Braun-Fahrländer C, Roduit C, Lauener R, Pfefferle PI, Weber J, von Mutius E; PASTURE Study Group.. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 131 3: 781-788. 2013
Determinants, reproducibility, and seasonal variation of ergosterol levels in house dust
Leppänen HK, Nevalainen A, Vepsäläinen A, Roponen M, Täubel M, Laine O, Rantakokko P, von Mutius E, Pekkanen J, Hyvärinen A. Indoor air 24 3: 248-259. 2013
Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood
Lluis A, Depner M, Gaugler B, Saas P, Liu L, Genuneit J, Pfefferle P, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Lauener R, Vuitton D, Dalphin J-C, Pekkanen J, von Mutius E, Schaub B and the PASTURE study group. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY - [Epub ahead of print]: -. 2013
Farm exposure and time trends in early childhood may influence DNA methylation in genes related to asthma and allergy
Michel S, Busato F, Genuneit J, Pekkanen J, Dalphin JC, Riedler J, Mazaleyrat N, Weber J, Karvonen AM, Hirvonen MR, Braun-Fahrländer C, Lauener R, von Mutius E, Kabesch M, Tost J; PASTURE study group.. ALLERGY 68 3: 355-364. 2013
Inflammatory response and IgE sensitization at early age
Mustonen K, Orivuori L, Keski-Nisula L, Hyvärinen A, Pfefferle PI, Riedler J, Dalphin JC, Genuneit J, Lauener R, Roduit C, Braun-Fahrländer C, Weber J, Schaub B, von Mutius E, Pekkanen J, Vaarala O; PASTURE Study Group.. PEDIATRIC ALLERGY AND IMMUNOLOGY 24 4: 395-401. 2013
Soluble immunoglobulin A in breast milk is inversely associated with atopic dermatitis at early age: The PASTURE cohort study
Orivuori L, Loss G, Roduit C, Dalphin JC, Depner M, Genuneit J, Lauener R, Pekkanen J, Pfefferle P, Riedler J, Roponen M, Weber J, von Mutius E, Braun-Fahrländer C, Vaarala O; ThePASTURE Study Group. CLINICAL AND EXPERIMENTAL ALLERGY Epub: x-x. 2013
Effect of moisture-damage intervention on the immunotoxic potential and microbial content of airborne particles and on occupants' upper airway inflammatory responses
Roponen M, Meklin T, Rintala H, Hyvärinen A, Hirvonen MR. INDOOR AIR 23 4: 295-302. 2013
Occurrence of moisture problems in schools in three countries from different climatic regions of Europe based on questionnaires and building inspections - the HITEA study.
Haverinen-Shaughnessy U, Borras-Santos A, Turunen M, Zock JP, Jacobs J, Krop EJ, Casas L, Shaughnessy R, Täubel M, Heederik D, Hyvärinen A, Pekkanen J, Nevalainen A; HITEA study group (Bloom E, Chen CM, Doekes G, Heinrich J, Hirvonen MR, Huttunen K, Jarvis D, Krska R, Leppänen H, Peitzsch M,, Rintala H, Roponen M, Sulyok M, Sunyer J,Tischer C, Torrens M, Tiittanen P, Valkonen M, Vepsäläinen A, Vis. INDOOR AIR 22 3: 457-466. 2012
Exposure to microbial agents in house dust and wheezing, atopic dermatitis and atopic sensitization in early childhood: a birth cohort study in rural areas
Karvonen AM, Hyvärinen A, Gehring U, Korppi M, Doekes G, Riedler J, Braun-Fahrländer C, Bitter S, Schmid S, Keski-Nisula L, Roponen M, Kaulek V, Dalphin J-C, Pfefferle PI, Renz H, Büchele G, von Mutius E, Pekkanen J, the PASTURE Study Group. CLINICAL AND EXPERIMENTAL ALLERGY 42 8: 1246-1256. 2012
High Indoor Microbial Levels Are Associated with Reduced Th1 Cytokine Secretion Capacity in Infancy
Lappalainen Mikko Harri Juhani, Hyvärinen Anne, Hirvonen Maija-Riitta, Rintala Helena, Roivainen Jarkko, Renz Harald, Pfefferle Petra Ina, Nevalainen Aino, Roponen Marjut, Pekkanen Juha. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 159: 194-203. 2012
Prenatal and early-life exposures alter expression of innate immunity genes: The PASTURE cohort study
Loss Georg, Bitter Sondhja, Wohlgensinger Johanna, Frei Remo, Roduit Caroline, Genuneit Jon, Pekkanen Juha, Roponen Marjut, Hirvonen Maija-Riitta, Dalphin Jean-Charles, Dalphin Marie-Laure, Riedler Josef, von Mutius Erika, Weber Juliane, Kabesch Michael, Michel Sven, Braun-Fahrländer Charlotte, Lauener Roger, PASTURE study group. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 130 2: 523-530. 2012
Few associations between high-sensitivity C-reactive protein and environmental factors in 4.5-year-old children
Mustonen K, Keski-Nisula L, Vaarala O, Pfefferle PI, Renz H, Riedler J, Dalphin JC, Buechele G, Lauener R, Braun-Fahrländer C, von Mutius E, Pekkanen J, the PASTURE Study Group, 19 jäsentä; Remes S. PEDIATRIC ALLERGY AND IMMUNOLOGY 23 6: 522-528. 2012
Development of atopic dermatitis according to age of onset and association with early-life exposures
Roduit Caroline, Frei Remo, Loss Georg, Büchele Gisela, Weber Juliane, Depner Martin, Loeliger Susanne, Dalphin Marie-Laure, Roponen Marjut, Hyvärinen Anne, Riedler Josef, Dalphin Jean-Charles, Pekkanen Juha, von Mutius Erika, Braun-Fahrländer Charlotte, Lauener Roger, PASTURE study group. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 130 1: 130-136. 2012
Analytical performance of a multiplexed, bead-based cytokine detection system in small volume samples
Bomert M, Köllisch G, Roponen M, Lauener R, Renz H, Pfefferle PI, Al-Fakhri N. CLINICAL CHEMISTRY AND LABORATORY MEDICINE 49 10: 1691-1693. 2011
Determinants of stimulated peripheral blood cytokine production among farming women
Lampi J, Roponen M, Hyvärinen A, Hirvonen MR, Larsson L, Nevalainen A, Pekkanen J. INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 214 3: 205-209. 2011
Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis
Roduit C, Wohlgensinger J, Frei R, Bitter S, Bieli C, Loeliger S, Büchele G, Riedler J, Dalphin JC, Remes S, Roponen M, Pekkanen J, Kabesch M, Schaub B, von Mutius E, Braun-Fahrländer C, Lauener R; PASTURE Study Group.. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 127 1: 179-185. 2011
Production of interleukin-5, -10 and interferon-g in cord blood is strongly associated with the season of birth
Keski-Nisula L, Lappalainen MHJ, Mustonen K, Hirvonen M-R, Pfefferle PI, Renz H, Pekkanen J & Roponen M. CLINICAL AND EXPERIMENTAL ALLERGY 40: 1658-1668. 2010
Exposure to dogs is associated with a decreased tumour necrosis factor-&#945 -producing capacity in early life
Lappalainen MHJ, Huttunen K, Roponen M, Remes S, Hirvonen M-R & Pekkanen J. 2010. Exposure to dogs is associated with a decreased tumour necrosis factor-α-producing capacity in early life. Clinical & Experimental Allergy 40 10: 1498- 2010
Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: The PASTURE Study
Pfefferle PI, Büchele G, Blümer N, Roponen M, Ege MJ, Krauss-Etschmann S, Genuneit J, Hyvärinen A, Hirvonen MR, Lauener R, Pekkanen J, Riedler J, Dalphin JC, Brunekreef B, Braun-Fahrländer C, von Mutius E, Renz H & PASTURE Study Group. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 125 1: 108-115. 2010
Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood
Rochat MK, Ege MJ, Plabst D, Steinle J, Bitter S, Braun-Fahrländer C, Dalphin J-C, Riedler J, Roponen M, Hirvonen M-R, Büchele G, Renz H, Lauener R, Krauss-Etschmann S, Von Mutius E &the PASTURE Study group. CLINICAL AND EXPERIMENTAL ALLERGY 40 5: 786-794. 2010
Toll-like receptor 7 function is reduced in adolescents with asthma
Roponen M, Yerkovich ST, Hollams E, Sly PD, Holt PG & Upham JW. EUROPEAN RESPIRATORY JOURNAL 35 1: 64-71. 2010

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Marjut Roponen

Research groups

Keywords

Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers

Short-Term Effects of Particle Sizes and Constituents on Blood Biomarkers among Healthy Young Adults in Guangzhou, China

Short-Term Effects of Particle Size and Constituents on Blood Pressure in Healthy Young Adults in Guangzhou, China

Associations of Particulate Matter Sizes and Chemical Constituents with Blood Lipids: A Panel Study in Guangzhou, China

Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles

Toxicological and microbiological characterization of cow stable dust

Mitogen-activated protein kinase signaling in childhood asthma development and environment-mediated protection

Early age exposure to moisture and mould is related to FeNO at the age of 6 years

Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma

Thermal dose as a universal tool to evaluate nanoparticle-induced photothermal therapy

Cryopreservation Affected the Levels of Immune Responses of PBMCs and Antigen-Presenting Cells

Urban air PM modifies differently immune defense responses against bacterial and viral infections in vitro

Association Between Residential Greenness, Cardiometabolic Disorders, and Cardiovascular Disease Among Adults in China

Is PM 1 similar to PM 2.5? A new insight into the association of PM 1 and PM 2.5 with children's lung function

Modification of caesarean section on the associations between air pollution and childhood asthma in seven Chinese cities

Greenness surrounding schools is associated with lower risk of asthma in schoolchildren.

Parents know it best: Prediction of asthma and lung function by parental perception of early wheezing episodes

Farm-like indoor microbiota in non-farm homes protects children from asthma development

Maatalomainen kodin mikrobisto voi suojata astmalta kaupungissakin

TNF-α-induced protein 3 is a key player in childhood asthma development and environment-mediated protection

Benefits of influenza vaccination on the associations between ambient air pollution and allergic respiratory diseases in children and adolescents: New insights from the Seven Northeastern Cities study in China

Association between antibiotic treatment during pregnancy & infancy and the development of allergic diseases

Ambient Airborne Particulates of Diameter less than or equal to 1 micrometre, a Leading Contributor to the Association Between Ambient Airborne Particulates of Diameter less than or equal to 2.5 micrometres and Children's Blood Pressure

Greenness around schools associated with lower risk of hypertension among children: Findings from the Seven Northeastern Cities Study in China

Prenatal exposure to perfluoroalkyl substances is associated with lower hand, foot and mouth disease viruses antibody response in infancy: Findings from the Guangzhou Birth Cohort Study

Association of Breastfeeding and Air Pollution Exposure With Lung Function in Chinese Children

Protective effects of breastfeeding on respiratory symptoms in infants with 17q21 asthma risk variants

A panel study of airborne particulate matter concentration and impaired cardiopulmonary function in young adults by two different exposure measurement

Early age exposure to moisture damage and systemic inflammation at the age of 6 years

Integrating farm and air pollution studies in search for immunoregulatory mechanisms operating in protective and high-risk environments

High levels of Butyrate and Propionate in early life are associated with protection against atopy

Is smaller worse? New insights about associations of PM1 and respiratory health in children and adolescents

Functional phenotypes determined by fluctuation-based clustering of lung function measurements in healthy and asthmatic cohort participants

Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis

Latent class analysis reveals clinically relevant atopy phenotypes in two birth cohorts

The lack of natural processes of delivery and neonatal intensive care treatment lead to impaired cytokine responses later in life

Phenotypes of atopic dermatitis depending on the timing of onset and progression in childhood

Asthmatic farm children show increased CD3+CD8low T-cells compared to non-asthmatic farm children

Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children

Enhanced T helper 1 and 2 cytokine responses at birth associate with lower risk of middle ear infections in infancy

Associations of Early Life Exposures and Environmental Factors With Asthma Among Children in Rural and Urban Areas of Guangdong, China

Associations of natural history and environmental factors with asthma among children in rural and urban areas of Guangdong, China

The Early Development of Wheeze: Environmental Determinants and Genetic Susceptibility at 17q21

Maatila-altistuminen muokkaa lasten immuunivastetta sääteleviä mekanismeja

IL-33 polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort

A switch in regulatory T cells through farm-exposure during immune maturation in childhood

Exposure to a farm environment is associated with Th1 and regulatory cytokines at age 4.5 years

Circulating dendritic cells, farm exposure and asthma at early age

Farm exposures are associated with lower percentage of circulating myeloid dendritic cell subtype 2 at age 6

Moisture damage in home associates with systemic inflammation in children

High level of fecal calprotectin at age 2 months as a marker of intestinal inflammation predicts atopic dermatitis and asthma by age 6

Clinical and Epidemiologic Phenotypes of Childhood Asthma

The effect of assay type and sample matrix on detected cytokine concentrations in human blood serum and nasal lavage fluid

Determinants, reproducibility, and seasonal variation of bacterial cell wall components and viable counts in house dust

Consumption of unprocessed cow's milk protects infants from common respiratory infections

Immunoglobulin A and immunoglobulin G antibodies against ß-lactoglobulin and gliadin at age 1 associate with immunoglobulin E sensitization at age 6

Increased food diversity in the first year of life is inversely associated with allergic diseases

Atopic sensitization in the first year of life

Determinants, reproducibility, and seasonal variation of ergosterol levels in house dust

Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood

Farm exposure and time trends in early childhood may influence DNA methylation in genes related to asthma and allergy

Inflammatory response and IgE sensitization at early age

Soluble immunoglobulin A in breast milk is inversely associated with atopic dermatitis at early age: The PASTURE cohort study

Effect of moisture-damage intervention on the immunotoxic potential and microbial content of airborne particles and on occupants' upper airway inflammatory responses

Occurrence of moisture problems in schools in three countries from different climatic regions of Europe based on questionnaires and building inspections - the HITEA study.

Exposure to microbial agents in house dust and wheezing, atopic dermatitis and atopic sensitization in early childhood: a birth cohort study in rural areas

High Indoor Microbial Levels Are Associated with Reduced Th1 Cytokine Secretion Capacity in Infancy

Prenatal and early-life exposures alter expression of innate immunity genes: The PASTURE cohort study

Few associations between high-sensitivity C-reactive protein and environmental factors in 4.5-year-old children

Development of atopic dermatitis according to age of onset and association with early-life exposures

Analytical performance of a multiplexed, bead-based cytokine detection system in small volume samples

Determinants of stimulated peripheral blood cytokine production among farming women

Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis

Production of interleukin-5, -10 and interferon-g in cord blood is strongly associated with the season of birth

Exposure to dogs is associated with a decreased tumour necrosis factor-&#945 -producing capacity in early life

Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: The PASTURE Study

Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood