Markku Laakso

Kemppainen, Susanna Maria; Silva, Lilian Fernandes; Lankinen, Maria Anneli; Schwab, Ursula; Laakso, Markku. 2022. Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 Men Metabolites 12 1: 69. 2022

Kurilshikov, Alexander; Medina-Gomez, Carolina; Bacigalupe, Rodrigo; Radjabzadeh, Djawad; Wang, Jun; Demirkan, Ayse; Le Roy, Caroline I.; Raygoza Garay, Juan Antonio; Finnicum, Casey T.; Liu, Xingrong; Zhernakova, Daria V.; Bonder, Marc Jan; Hansen, Tue H.; Frost, Fabian; Ruehlemann, Malte C.; Turpin, Williams; Moon, Jee-Young; Kim, Han-Na; Lull, Kreete; Barkan, Elad et al. (Incl Laakso, Markku). 2021. Large-scale association analyses identify host factors influencing human gut microbiome composition Nature genetics 53 2: 156-165. 2021

Aasmets, Oliver; Lüll, Kreete; Lang, Jennifer M; Pan, Calvin; Kuusisto, Johanna; Fischer, Krista; Laakso, Markku; Lusis, Aldons J; Org, Elin. 2021. Machine Learning Reveals Time-Varying Microbial Predictors with Complex Effects on Glucose Regulation MSystems 6 1: e-01191-20. 2021

Wu, CY; Borné, Y; Gao, R; Rodriguez, ML; Roell, WC; Wilson, JM; Regmi, A; Luan, C; Aly, DM; Peter, A; Machann, J; Staiger, H; Fritsche, A; Birkenfeld, AL; Tao, R; Wagner, R; Canouil, M; Hong, MG; Schwenk, JM [incl. Laakso, M]. 2021. Elevated circulating follistatin associates with an increased risk of type 2 diabetes Nature communications 12: 6486. 2021

Tura, Andrea; Grespan, Eleonora; Göbl, Christian S; Koivula, Robert W; Franks, Paul W; Pearson, Ewan R; Walker, Mark; Forgie, Ian M; Giordano, Giuseppe N; Pavo, Imre; Ruetten, Hartmut; Dermitzakis, Emmanouil T; McCarthy, Mark I; Pedersen, Oluf; Schwenk, Jochen M; Adamski, Jerzy; De Masi, Federico; Tsirigos, Konstantinos D; Brunak, Søren; Viñuela, Ana et al. [incl. Kokkola, Tarja; Vangipurapu Jaga. 2021. Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study Diabetes 70 96: 2092-2106. 2021

Schwab, Ursula; Lankinen, Maria; Laakso, Markku. 2021. Effect of lifestyle intervention on the risk of incident diabetes in individuals with impaired fasting glucose and low or high genetic risk for the development of type 2 diabetes in men: a T2D-GENE trial Food and nutrition research 65: 1-7. 2021

Rebelos, Eleni; Bucci, Marco; Karjalainen, Tomi; Oikonen, Vesa; Bertoldo, Alessandra; Hannukainen, Jarna C.; Virtanen, Kirsi A.; Latva-Rasku, Aino; Hirvonen, Jussi; Heinonen, Ilkka; Parkkola, Riitta; Laakso, Markku; Ferrannini, Ele; Iozzo, Patricia; Nummenmaa, Lauri; Nuutila, Pirjo. 2021. Insulin Resistance Is Associated With Enhanced Brain Glucose Uptake During Euglycemic Hyperinsulinemia: A Large-Scale PET Cohort Diabetes care 44 3: 788-794. 2021

Qian, Frank; Korat, Andres V Ardisson; Imamura, Fumiaki; Marklund, Matti; Tintle, Nathan; Virtanen, Jyrki K; Zhou, Xia; Bassett, Julie K; Lai, Heidi; Hirakawa, Yoichiro; Chien, Kuo-Liong; Wood, Alexis C; Lankinen, Maria; Murphy, Rachel A; Samieri, Cecilia; Pertiwi, Kamalita; de Mello, Vanessa D; Guan, Weihua; Forouhi, Nita G; Wareham, Nick et al. (Incl Laakso, Markku). 2021. n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies Diabetes care 44 5: 1133-1142. 2021

Pan, David Z; Miao, Zong; Comenho, Caroline; Rajkumar, Sandhya; Koka, Amogha; Lee, Seung Hyuk T; Alvarez, Marcus; Kaminska, Dorota; Ko, Arthur; Sinsheimer, Janet S; Mohlke, Karen L; Mancuso, Nicholas; Muñoz-Hernandez, Linda Liliana; Herrera-Hernandez, Miguel; Tusié-Luna, Maria Teresa; Aguilar-Salinas, Carlos; Pietiläinen, Kirsi H; Pihlajamäki, Jussi; Laakso, Markku; Garske, Kristina M; et al.. 2021. Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes Genome medicine 13: 123. 2021

Mägi, Reedik; Hottenga, Jouke- Jan; Grallert, Harald; Perry, John R. B.; Bouatia-Naji, Nabila; Marullo, Letizia; Rybin, Denis; Jansen, Rick; Min, Josine L.; Dimas, Antigone S.; Ulrich, Anna; Zudina, Liudmila; Gådin, Jesper R.; Jiang, Longda; Faggian, Alessia; Bonnefond, Amélie; Fadista, Joao; Stathopoulou, Maria G.; Isaacs, Aaron; Willems, Sara M et al. [incl. Kuusisto, Johanna; Laakso, Markku; La. 2021. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability Nature communications 12 1: 24. 2021

Meuronen, Topi; Lankinen, Maria A.; Kärkkäinen, Olli; Laakso, Markku; Pihlajamäki, Jussi; Hanhineva, Kati; Schwab, Ursula. 2021. FADS1 rs174550 genotype and high linoleic acid diet modify plasma PUFA phospholipids in a dietary intervention study European journal of nutrition 2022; 61 2: 1109-1120. 2021

McGuire, Daniel; Jiang, Yu; Liu, Mengzhen; Weissenkampen, J. Dylan; Eckert, Scott; Yang, Lina; Chen, Fang; GWAS and Sequencing Consortium of Alcohol and Nicotine Use (GSCAN); Berg, Arthur; Vrieze, Scott; Jiang, Bibo; Li, Qunhua; Liu, Dajiang J. et al. [ incl. Laakso, Markku]. 2021. Model-based assessment of replicability for genome-wide association meta-analysis Nature communications 12 1: 1964. 2021

Lipponen, Joonas; Helisalmi, Seppo; Raivo, Joose; Siitonen, Ari; Doi, Hiroshi; Rusanen, Harri; Lehtilahti, Maria; Ryytty, Mervi; Laakso, Markku; Tanaka, Fumiaki; Majamaa, Kari; Kytövuori, Laura. 2021. Molecular epidemiology of hereditary ataxia in Finland Bmc neurology 21 1: 382. 2021

Lankinen, MA; de Mello, VD; Meuronen, T; Sallinen, T; Ågren, J; Virtanen, KA; Laakso, M; Pihlajamäki, J; Schwab, U. 2021. The FADS1 Genotype Modifes Metabolic Responses to the Linoleic Acid and Alpha-linolenic Acid Containing Plant Oils-Genotype Based Randomized Trial FADSDIET2 Molecular nutrition and food research 65 7: 2001004. 2021

Perrin, Hannah J; Currin, Kevin W; Vadlamudi, Swarooparani; Pandey, Gautam K; Ng, Kenneth K; Wabitsch, Martin; Laakso, Markku; Love, Michael I; Mohlke, Karen L. 2021. Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci PLoS genetics 17 10: e1009865. 2021

Krishnan, Karthickeyan Chella; Vergnes, Laurent; Acín-Pérez, Rebeca; Stiles, Linsey; Shum, Michael; Ma, Lijiang; Mouisel, Etienne; Pan, Calvin; Moore, Timothy M; Péterfy, Miklós; Romanoski, Casey E; Reue, Karen; Bjorkegren, Johan LM; Laakso, Markku; Liesa, Marc; Lusis, Aldons J. 2021. Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2 Nature metabolism 3 11: 1552-1568. 2021

Graham, Sarah E; Clarke, Shoa L; Wu, Kuan-Han H; Kanoni, Stavroula; Zajac, Greg JM; Ramdas, Shweta; Surakka, Ida; Ntalla, Ioanna; Vedantam, Sailaja; Winkler, Thomas W; Locke, Adam E; Marouli, Eirini; Hwang, Mi Yeong; Han, Sohee; Narita, Akira; Choudhury, Ananyo; Bentley, Amy R; Ekoru, Kenneth; Verma, Anurag; Trivedi, Bhavi [incl. Kuusisto, Johanna; Laakso, Markku]. 2021. The power of genetic diversity in genome-wide association studies of lipids Nature 600 7890: 675-679. 2021

Keinan, Omer; Valentine, Joseph M; Xiao, Haopeng; Mahata, Sushil K; Reilly, Shannon M; Abu-Odeh, Mohammad; Deluca, Julia H; Dadpey, Benyamin; Cho, Leslie; Pan, Austin; Yu, Ruth T; Dai, Yang; Liddle, Christopher; Downes, Michael; Evans, Ronald M; Lusis, Aldons J; Laakso, Markku; Chouchani, Edward T; Ryde'n, Mikael; Saltiel, Alan R. 2021. Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes Nature 599 7884: 296-301. 2021

Chen, J; Spracklen, CN; Marenne, G; Varshney, A; Corbin, LJ; Luan, J; Willems, SM; Wu, Y; Zhang, X; Horikoshi, M; Boutin, TS; Mägi, R; Waage, J; Li-Gao, R; Chan, KHK; Yao, J; Anasanti, MD; Chu, AY; Claringbould, A; Heikkinen, J; et al. [incl. Kuulasmaa, T; Kuusisto, J; Laakso, M; Lakka, T; Uusitupa, M; Vangipurapu, J]. 2021. The trans-ancestral genomic architecture of glycemic traits Nature genetics 53 6: 840-860. 2021

Chen, Lei; Abel, Haley J; Das, Indraniel; Larson, David E; Ganel, Liron; Kanchi, Krishna L; Regier, Allison A; Young, Erica P; Kang, Chul Joo; Scott, Alexandra J; Chiang, Colby; Wang, Xinxin; Lu, Shuangjia; Christ, Ryan; Service, Susan K; Chiang, Charleston WK; Havulinna, Aki S; Kuusisto, Johanna; Boehnke, Michael; Laakso, Markku et al.. 2021. Association of structural variation with cardiometabolic traits in Finns American journal of human genetics 108 4: 583-596. 2021

Fernandes Silva, Lilian; Vangipurapu, Jagadish; Laakso, Markku. 2021. The "Common Soil Hypothesis" Revisited - Risk Factors for Type 2 Diabetes and Cardiovascular Disease Metabolites 11 10: 691. 2021

Goodrich, JK; Singer-Berk, M; Son, R; Sveden, A; Wood, J; England, E; Cole, JB; Weisburd, B; Watts, N; Caulkins, L; Dornbos, P; Koesterer, R; Zappala, Z; Zhang, H; Maloney, KA; Dahl, A; Aguilar-Salinas, CA; Atzmon, G; Barajas-Olmos, F; Barzilai, N; et al; [incl. Kuusisto, J; Laakso, M]. 2021. Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes Nature communications 12 1: 3505. 2021

Ganel, Liron; Chen, Lei; Christ, Ryan; Vangipurapu, Jagadish; Young, Erica; Das, Indraniel; Kanchi, Krishna; Larson, David; Regier, Allison; Abel, Haley; Kang, Chul Joo; Scott, Alexandra; Havulinna, Aki; Chiang, Charleston WK; Service, Susan; Freimer, Nelson; Palotie, Aarno; Ripatti, Samuli; Kuusisto, Johanna; Boehnke, Michael; Laakso, Markku; Locke, Adam; Stitziel, Nathan O; Hall, Ira M. 2021. Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences Human genomics 15 1: 1-17. 2021

Gudmundsson, Sanna; Karczewski, Konrad J.; Francioli, Laurent C.; Tiao, Grace; Cummings, Beryl B.; Alföldi, Jessica; Wang, Qingbo; Collins, Ryan L.; Laricchia, Kristen M.; Ganna, Andrea; Birnbaum, Daniel P.; Gauthier, Laura D.; Brand, Harrison; Solomonson, Matthew; Watts, Nicholas A.; Rhodes, Daniel; Singer-Berk, Moriel; England, Eleina M.; Seaby, Eleanor G.; Kosmicki, Jack A. et al [incl. Hiltune. 2021. Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans Nature 597 7874: E3-E4. 2021

Gurzeler, Erika; Ruotsalainen, Anna-Kaisa; Laine, Anssi; Valkama, Teemu; Kettunen, Sanna; Laakso, Markku; Ylä-Herttuala, Seppo. 2021. SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice PLoS ONE 16 11: e025840. 2021

Harris, William S; Tintle, Nathan L; Imamura, Fumiaki; Qian, Frank; Korat, Andres V Ardisson; Marklund, Matti; Djousse, Luc; Bassett, Julie K; Carmichael, Pierre-Hugues; Chen, Yun-Yu; Hirakawa, Yoichiro; Kupers, Leanne K; Laguzzi, Federica; Lankinen, Maria; Murphy, Rachel A; Samieri, Cecilia; Senn, Mackenzie K; Shi, Peilin; Virtanen, Jyrki K; Brouwer, Ingeborg A et al; The Fatty Acids and Outcomes. 2021. Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies Nature communications 12 1: 2329. 2021

Hindy, George; Dornbos, Peter; Chaffin, Mark D.; Liu, Dajiang J.; Wang, Minxian; Selvaraj, Margaret Sunitha; Zhang, David; Park, Joseph; Aguilar-Salinas, Carlos A.; Antonacci-Fulton, Lucinda; Ardissino, Diego; Arnett, Donna K.; Aslibekyan, Stella; Atzmon, Gil; Ballantyne, Christie M.; Barajas-Olmos, Francisco; Barzilai, Nir; Becker, Lewis C.; Bielak, Lawrence F.; Bis, Joshua C. et al [incl. Kuusis. 2021. Rare coding variants in 35 genes associate with circulating lipid levels - A multi-ancestry analysis of 170,000 exomes American journal of human genetics 2022; 109 1: 81 - 96. 2021

Jauhiainen, Raimo; Vangipurapu, Jagadish; Laakso, Annamaria; Kuulasmaa, Teemu; Kuusisto, Johanna; Laakso, Markku. 2021. The association of nine amino acids with cardiovascular events in Finnish men in a 12-year follow-up study Journal of clinical endocrinology and metabolism 106 12: 3448-3454. 2021

Minikel, Eric Vallabh; Karczewski, Konrad J; Martin, Hilary C; Cummings, Beryl B; Whiffin, Nicola; Rhodes, Daniel; Alföldi, Jessica; Trembath, Richard C; van Heel, David A; Daly, Mark J; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium; Schreiber, Stuart L; MacArthur, Daniel G [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. 2020. Evaluating drug targets through human loss-of-function genetic variation Nature 581 7809: 459-464. 2020

Surendran, Praveen; Feofanova, Elena V; Lahrouchi, Najim; Ntalla, Ioanna; Karthikeyan, Savita; Cook, James; Chen, Lingyan; Mifsud, Borbala; Yao, Chen; Kraja, Aldi T; Cartwright, James H; Hellwege, Jacklyn N; Giri, Ayush; Tragante, Vinicius; Thorleifsson, Gudmar; Liu, Dajiang J; Prins, Bram P; Stewart, Isobel D; Cabrera, Claudia P; Eales, James M; et al. (incl. Stanakova, Alena; Laatikainen, Tiina;. 2020. Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals Nature genetics 52: 1314-1332. 2020

Mäkinen, Selina; Datta, Neeta; Nguyen, Yen H; Kyrylenko, Petro; Laakso, Markku; Koistinen, Heikki A. 2020. Simvastatin profoundly impairs energy metabolism in primary human muscle cells Endocrine connections 9 11: 1103-1113. 2020

Männistö, Jonna; Maria, Maleeha; Raivo, Joose; Kuulasmaa, Teemu; Otonkoski, Timo; Huopio, Hanna; Laakso, Markku. 2020. Clinical and Genetic Characterization of 153 Patients with Persistent or Transient Congenital Hyperinsulinism Journal of clinical endocrinology and metabolism 105 4: 1-9. 2020

Obura, M; Beulens, JWJ; Slieker, R; Koopman, ADM; Hoekstra, T; Nijpels, G; Elders, P; Dekker, JM; Koivula, RW; Kurbasic, A; Laakso, M; Hansen, TH; Ridderstråle, M; Hansen, T; Pavo, I; Forgie, I; Jablonka, B; Ruetten, H; Mari, A; McCarthy, MI; Walker, M; et al.. 2020. Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time: an IMI-DIRECT study Diabetic medicine 2021; 38 2: e14428. 2020

Obura, Morgan; Beulens, Joline W J; Slieker, Roderick; Koopman, Anitra D M; Hoekstra, Trynke; Nijpels, Giel; Elders, Petra; Koivula, Robert W; Kurbasic, Azra; Laakso, Markku; Hansen, Tue H; Ridderstråle, Martin; Hansen, Torben; Pavo, Imre; Forgie, Ian; Jablonka, Bernd; Ruetten, Hartmut; Mari, Andrea; McCarthy, Mark I; Walker, Mark; et al.. 2020. Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study PLoS ONE 15 11: e0242360. 2020

Rolova, Taisia; Wu, Ying-Chieh; Koskuvi, Marja; Voutilainen, Jenni; Sonninen, Tuuli-Maria; Kuusisto, Johanna; Laakso, Markku; Hämäläinen, Riikka H; Koistinaho, Jari; Lehtonen, Sárka. 2020. Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer's disease Stem cell research 48: 101968. 2020

Zhou, Zhenqi; Moore, Timothy M; Drew, Brian G; Ribas, Vicent; Wanagat, Jonathan; Civelek, Mete; Segawa, Mayuko; Wolf, Dane M; Norheim, Frode; Seldin, Marcus M; Strumwasser, Alexander R; Whitney, Kate A; Lester, Ellen; Reddish, Britany R; Vergnes, Laurent; Reue, Karen; Rajbhandari, Prashant; Tontonoz, Peter; Lee, Jason; Mahata, Sushil K et al [incl. Laakso, Markku]. 2020. Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling Science translational medicine 12 555: eaax8096. 2020

Valtola, K; Nino-Quintero, J; Hedman, M; Lottonen-Raikaslehto, L; Laitinen, T; Maria, M; Kantola, I; Naukkarinen, A; Laakso, M; Kuusisto, J. 2020. Cardiomyopathy associated with the Ala143Thr variant of the α-galactosidase A gene Heart 106 8: 609-615. 2020

van Zuydam, Natalie R; Ladenvall, Claes; Voight, Benjamin F; Strawbridge, Rona J; Fernandez-Tajes, Juan; Rayner, N William; Robertson, Neil R; Mahajan, Anubha; Vlachopoulou, Efthymia; Goel, Anuj; Kleber, Marcus E; Nelson, Christopher P; Kwee, Lydia Coulter; Esko, Tõnu; Mihailov, Evelin; Mägi, Reedik; Milani, Lili; Fischer, Krista; Kanoni, Stavroula; Kumar, Jitender; et al. [incl; Laakso, Markku]. 2020. Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus Circulation 13 6: e002769. 2020

Vangipurapu, Jagadish; Fernandes Silva, Lilian; Kuulasmaa, Teemu; Smith, Ulf; Laakso, Markku. 2020. Microbiota-Related Metabolites and the Risk of Type 2 Diabetes Diabetes care 43 6: 1319-1325. 2020

Wang, Qingbo; Pierce-Hoffman, Emma; Cumings, Beryl B; Alföldi, Jessica; Francioli, Laurent C; Gauthier, Laura D; Hill, Andrew J; O'Donnell-Luria, Anne H; Genome Aggregation Database Production Team, Genome Aggregation Database Consortium [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. 2020. Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes Nature communications 11: 2539. 2020

Whiffin, Nicola; Armean, Irina M; Kleinman, Aaron; Marshall, Jamie L; Minikel, Eric V; Goodrich, Julia K; Quaife, Nicholas M; Cole, Joanne B; Wang, Qingbo; Karczewski, Konrad J; Cummings, Beryl B; Francioli, Laurent; Laricchia, Kristen; Guan, Anna; Alipanahi, Babak; Morrison, Peter; Baptista, Marco AS; Merchant, Kalpana M; Genome Aggregation Database Production Team; Genome Aggregation Database Co. 2020. The effect of LRRK2 loss-of-function variants in humans Nature medicine 26: 869-877. 2020

Whiffin, Nicola; Karczewski, Konrad J; Zhang, Xiaolei; Chothani, Sonia; Smith, Miriam J; Evans, D Gareth; Roberts, Angharad M; Quaife, Nicholas M; Schafer, Sebastian; Rackham, Owen; Alföldi, Jessica; O'Donnell-Luria, Anne H; Francioli, Laurent C; Genome Aggregation Database Production Team, Genome Aggregation Database Consortium [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. 2020. Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals Nature communications 11: 2523. 2020

Mefford, Joel; Park, Danny; Zheng, Zhili; Ko, Arthur; Ala-Korpela, Mika; Laakso, Markku; Pajukanta, Päivi; Yang, Jian; Witte, John; Zaitlen, Noah. 2020. Efficient Estimation and Applications of Cross-Validated Genetic Predictions to Polygenic Risk Scores and Linear Mixed Models Journal of computational biology 27 4: 599-612. 2020

Miao, Zong; Alvarez, Marcus; Ko, Arthur; Bhagat, Yash; Rahmani, Elior; Jew, Brandon; Heinonen, Sini; Muñoz-Hernandez, Linda Liliana; Herrera-Hernandez, Miguel; Aguilar-Salinas, Carlos; Tusie-Luna, Teresa; Mohlke, Karen L; Laakso, Markku; Pietiläinen, Kirsi H; Halperin, Eran; Pajukanta, Päivi. 2020. The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance PLoS genetics 16 9: e1009018. 2020

Spracklen, Cassandra N; Iyengar, Apoorva K; Vadlamudi, Swarooparani; Raulerson, Chelsea K; Jackson, Anne U; Brotman, Sarah M; Wu, Ying; Cannon, Maren E; Davis, James P; Crain, Aaron T; Currin, Kevin W; Perrin, Hannah J; Narisu, Narisu; Stringham, Heather M; Fuchsberger, Christian; Locke, Adam E; et al. [incl. Laakso, Markku]. 2020. Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences PLoS genetics 16 9: e1009019. 2020

Lankinen, Maria; Schwab, Ursula; Laakso, Markku. 2020. Ryhmissä toteutettavalla elämäntapaohjauksella on merkittäviä tuloksia terveyteen KEHITTYVÄ ELINTARVIKE 3: 50-51. 2020

Gudmundsdottir, Valborg; Pedersen, Helle Krogh; Mazzoni, Gianluca; Allin, Kristine H; Artati, Anna; Beulens, Joline W; Banasik, Karina; Brorsson, Caroline; Cederberg, Henna; Chabanova, Elizaveta; De Masi, Federico; Elders, Petra J; Forgie, Ian; Giordano, Giuseppe N; Grallert, Harald; Gupta, Ramneek; Haid, Mark; Hansen, Torben; Hansen, Tue H; Hattersley, Andrew T; et al. [incl. Kokkola, Tarja; Laak. 2020. Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study Genome medicine 12 1: 109. 2020

Lankinen, Maria; Laakso, Markku; Schwab, Ursula. 2020. Voidaanko elintavoilla ehkäistä tyypin 2 diabtesta myös korkean geneettisen riskin omaavilla henkilöillä? Ravitsemusasiantuntija 6 1: 18-20. 2020

Atabaki-Pasdar, Naeimeh; Ohlsson, Mattias; Viñuela, Ana; Frau, Francesca; Pomares-Millan, Hugo; Haid, Mark; Jones, Angus G; Thomas, E Louise; Koivula, Robert W; Kurbasic, Azra; Mutie, Pascal M; Fitipaldi, Hugo; Fernandez, Juan; Dawed, Adem Y; Giordano, Giuseppe N; Forgie, Ian M; McDonald, Timothy J; Rutters, Femke; Cederberg, Henna; Chabanova, Elizaveta et al. [Incl. Kokkola, Tarja; Laakso Markku;. 2020. Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts PLoS medicine 17 6: e1003149. 2020

Bar, Noam; Korem, Tal; Weissbrod, Omer; Zeevi, David; Rothschild, Daphna; Leviatan, Sigal; Kosower, Noa; Lotan-Pompan, Maya; Weinberger, Adina; Le Roy, Caroline I; Menni, Cristina; Visconti, Alessia; Falchi, Mario; Spector, Tim D; Adamski, Jerzy; Franks, Paul W; Pedersen, Oluf; Segal, Eran; The IMI DIRECT Consortium [incl. Kuulasmaa, Teemu; Kokkola, Tarja; Laakso, Markku; Vangipurapu, Jagadish; Ce. 2020. A reference map of potential determinants for the human serum metabolome. Nature 588: 135-140. 2020

Collins, Ryan L; Brand, Harrison; Karczewski, Konrad J; Zhao, Xuefang; Alföldi, Jessica; Francioli, Laurent C; Khera, Armit V; Lowther, Chelsea; Gauthier, Laura D; Wang, Harold; Watts, Nicholas A; Solomonson, Matthew; O'Donnell-Luria, Anne; Baumann, Alexander; Munshi, Ruchi; Walker, Mark; Whelan, Christopher W; Huang, Yongqing; Brookings, Ted; Sharpe, Ted; et al.; Genome Aggregation Database Produ. 2020. A structural variation reference for medical and population genetics Nature 581 7809: 444-451. 2020

Cummings, Beryl B; Karczewski, Konrad J; Kosmicki, Jack A; Seaby, Eleanor G; Watts, Nicholas A; Singer-Berk, Moriel; Mudge, Jonathan M; Karjalainen, Juha; Satterstrom, F Kyle; O'Donnell-Luria, Anne H; Poterba, Timothy; Seed, Cotton; Solomonson, Matthew; Alföldi, Jessica; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium; Daly, Mark J; MacArthur, Daniel G; et al. [. 2020. Transcript expression-aware annotation improves rare variant interpretation Nature 581 7809: 452-458. 2020

Deshmukh, Harshal A; Madsen, Anne Lundager; Viñuela, Ana; Have, Christian Theil; Grarup, Niels; Tura, Andrea; Mahajan, Anubha; Heggie, Alison J; Koivula, Robert W; De Masi, Federico; Tsirigos, Konstantinos K; Linneberg, Allan; Drivsholm, Thomas; Pedersen, Oluf; Sørensen, Thorkild I A; Astrup, Arne; Gjesing, Anette A P; Pavo, Imre; Wood, Andrew R; Ruetten, Hartmut [et al incl. Laakso, Markku]. 2020. Genome-Wide Association Analysis of Pancreatic Beta Cell Glucose Sensitivity Journal of clinical endocrinology and metabolism 2021; 106 1: 80-90. 2020

Fernandes Silva, Lilian; Vangipurapu, Jagadish; Smith, Ulf; Laakso, Markku. 2020. Metabolite signature of albuminuria involves amino acid pathways in 8,661 Finnish men without diabetes Journal of clinical endocrinology and metabolism 2021; 106 1: 143-152. 2020

Acín-Pérez, Rebeca; Iborra, Salvador; Martí-Mateos, Yolanda; Cook, Emma C L; Conde-Garrosa, Ruth; Petcherski, Anton; Muñoz, M Del Mar; Martínez de Mena, Raquel; Krishnan, Karthickeyan Chella; Jiménez, Concepción; Bolaños, Juan Pedro; Laakso, Markku; Lusis, Aldon J; Shirihai, Orian S; Sancho, David; Enríquez, José Antonio. 2020. Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity Nature metabolism 2 9: 974-988. 2020

Abel, Haley J; Larson, David E; Regier, Allison A; Chiang, Colby; Das, Indraniel; Kanchi, Krishna L; Layer, Ryan M; Neale, Benjamin M; Salerno, William J; Reeves, Catherine Steven Buyske; NHGRI Centers for Common Disease Genomics; et al. [Incl. Laakso, Markku]. 2020. Mapping and characterization of structural variation in 17,795 human genomes Nature 583: 83-89. 2020

Jauhiainen, Raimo; Jauhiainen, Matti; Vangipurapu, Jagadish; Kuulasmaa, Teemu; Ala-Korpela, Mika; Laakso, Markku; Kuusisto, Johann. 2020. Novel biomarkers associated with incident heart failure in 10 106 Finnish men ESC heart failure 2021; 8 1: 605-614. 2020

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Freund, MK; Burch, KS; Shi, H; Mancuso, N; Kichaev, G; Garske, KM; Pan, DZ; Miao, Z; Mohlke, KL; Laakso, M; Pajukanta, P; Pasaniuc, B; Arboleda, VA. 2018. Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits American journal of human genetics 103 4: 535-552. 2018

Giri, A; Hellwege, JN; Keaton, JM; Park, J; Qiu, C; Warren, HR; Torstenson, ES; Kovesdy, CP; Sun, YV; Wilson, OD; Robinson-Cohen, C; Roumie, CL; Chung, CP; Birdwell, KA; Damrauer, SM; DuVall, SL; Klarin, D; Cho, K; Wang, Y; Evangelou, E; et al (incl. Laakso, Markku). 2018. Trans-ethnic association study of blood pressure determinants in over 750,000 individuals Nature genetics 2019; 51 1: 51-62. 2018

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Ganna, A; Satterstrom, FK; Zekavat, SM; Das, I; Kurki, MI; Churchhouse, C; Alfoldi, J; Martin, AR; Havulinna, A; Byrnes, A; Thompson, WK; Nielsen, PR; Karczewski, K; Saarentaus, E; Rivas, MA; Gupta, N; Pietiläinen, O; Emdin, CA; Lescai, F; Bybjerg-Grauholm, J; et al. (incl. Laakso, Markku). 2018. Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum American journal of human genetics 102 6: 1204-1211. 2018

Jalanko, Mikko; Heliö, Tiina; Mustonen, Pirjo; Kokkonen, Jorma; Huhtala, Heini; Laine, Mika; Jääskeläinen, Pertti; Tarkiainen, Mika; Lauerma, Kirsi; Sipola, Petri; Laakso, Markku; Kuusisto, Johanna; Nikus, Kjell. 2018. Novel electrocardiographic features in carriers of hypertrophic cardiomyopathy causing sarcomeric mutations Journal of electrocardiology 51 6: 983-989. 2018

Jiang, Y; Chen, S; McGuire, D; Chen, F; Liu, M; Iacono, WG; Hewitt, JK; Hokanson, JE; Krauter, K; Laakso, M; Li, KW; Lutz, SM; McGue, M; Pandit, A; Zajac, GJM; Boehnke, M; Abecasis, GR; Vrieze, SI; Zhan, X; Jiang, B; et al.. 2018. Proper conditional analysis in the presence of missing data: Application to large scale meta-analysis of tobacco use phenotypes PLoS genetics 14 7: e1007452. 2018

Koivumäki, Jussi T; Naumenko, Nikolay; Tuomainen, Tomi; Takalo, Jouni; Oksanen, Minna; Puttonen, Katja A; Lehtonen, Sarka; Kuusisto, Johanna; Laakso, Markku; Koistinaho, Jari; Tavi, Pasi. 2018. Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling. Frontiers in Physiology 9: 80. 2018

Kycia, I; Wolford, BN; Huyghe, JR; Fuchsberger, C; Vadlamudi, S; Kursawe, R; Welch, RP; Albanus, RD; Uyar, A; Khetan, S; Lawlor, N; Bolisetty, M; Mathur, A; Kuusisto, J; Laakso, M; Ucar, D; Mohlke, KL; Boehnke, M; Collins, FS; Parker, SCJ; et al.. 2018. A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression. AMERICAN JOURNAL OF HUMAN GENETICS 102 4: 620-635. 2018

Latva-Rasku, A; Honka, MJ; Stancáková, A; Koistinen, HA; Kuusisto, J; Guan, L; Manning, AK; Stringham, H; Gloyn, AL; Lindgren, CM; T2D-GENES Consortium; Collins, FS; Mohlke, KL; Scott, LJ; Karjalainen, T; Nummenmaa, L; Boehnke, M; Nuutila, P; Laakso, M. 2018. A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study. DIABETES (NY) 67 2: 334-342. 2018

Lehtonen, S; Höytyläinen, I; Voutilainen, J; Sonninen, T-M; Kuusisto, J; Laakso, M; Hämäläinen, RH; Oksanen, M; Koistinaho, J. 2018. Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease Stem cell research 30: 96-99. 2018

Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM et al.. 2017. Correction: The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue Cell reports 20 1: 279. 2017

Nederlof R, Denis S, Lauzier B, Rosiers CD, Laakso M, Hagen J, Argmann C, Wanders R, Houtkooper RH, Hollmann MW, Houten SM, Zuurbier CJ. 2017. Acute detachment of hexokinase II from mitochondria modestly increases oxygen consumption of the intact mouse heart. METABOLISM: CLINICAL AND EXPERIMENTAL 72: 66-74. 2017

Nikkola Elina, Ko Arthur, Alvarez Marcus, Cantor Rita M, Garske Kristina, Kim Elliot, Gee Stephanie, Rodriguez Alejandra, Muxel Reinhard, Matikainen Niina, Söderlund Sanni, Motazacker Mahdi M, Borén Jan, Lamina Claudia, Kronenberg Florian, Schneider Wolfgang J, Palotie Aarno, Laakso Markku, Taskinen Marja-Riitta, Pajukanta Päivi. 2017. Family-specific aggregation of lipid GWAS variants confers the susceptibility to familial hypercholesterolemia in a large Austrian family. ATHEROSCLEROSIS 264: 58-66. 2017

Org E, Blum Y, Kasela S, Mehrabian M, Kuusisto J, Kangas AJ, Soininen P, Wang ZN, Ala-Korpela M, Hazen SL, Laakso M, Lusis AJ. 2017. Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort. GENOME BIOLOGY [ONLINE] 18: 70. 2017

Patel KA, Kettunen J, Laakso M, Stancáková A, Laver TW, Colclough K, Johnson MB, Abramowicz M, Groop L, Miettinen PJ, Shepherd MH, Flanagan SE, Ellard S, Inagaki N1, Hattersley AT, Tuomi T, Cnop M, Weedon MN. 2017. Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance. Nature Communications 8: 888. 2017

Rauh Simone P, Heymans Martijn W, Koopman Anitra DM, Nijpels Giel, Stehouwer Coen D, Thorand Barbara, Rathmann Wolfgang, Meisinger Christa, Peters Annette, de las Heras Gala Tonia, Glümer Charlotte, Pedersen Olut, Cederberg Henna, Kuusisto Johanna, Laakso Markku, Pearson Ewan R, Franks Paul W, Rutters Femke, Dekker Jacqueline M. 2017. Predicting glycated hemoglobin levels in the non-diabetic general population: Development and validation of the DIRECT - DETECT prediction model - a DIRECT study. PLOS ONE 12 2: e0171816. 2017

Roman TS, Cannon ME, Vadlamudi S, Buchkovich ML, Wolford BN, Welch RP, Morken MA, Kwon GJ, Varshney A, Kursawe R, Wu Y, Jackson AU, Erdos MR, Kuusisto J, Laakso M, Scott LJ, Boehnke M, Collins FS, Parker SCJ, Stitzel ML, Mohlke KL. 2017. A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the Adcy5 Locus. DIABETES (NY) 66 9: 2521-2530. 2017

Ryhänen EM, Leijon H, Metso S, Eloranta E, Korsoff P, Ahtiainen P, Kekäläinen P, Tamminen M, Ristamäki R, Knutar O, Löyttyniemi E, Niskanen L, Väisänen M, Heiskanen I, Välimäki MJ, Laakso M, Haglund C, Arola J, Schalin-Jäntti C. 2017. A nationwide study on parathyroid carcinoma. ACTA ONCOLOGICA 56 7: 991-1003. 2017

Wu JHY, Marklund M, Imamura F, Tintle N, Ardisson Korat AV, de Goede J, Zhou X, Yang WS, de Oliveira Otto MC, Kröger J, Qureshi W, Virtanen JK, Bassett JK, Frazier-Wood AC, Lankinen M, Murphy RA, Rajaobelina K, Del Gobbo LC, Forouhi NG, Luben R, Khaw KT, Wareham N, Kalsbeek A, Veenstra J, Luo J, Hu FB, Lin HJ, Siscovick DS, Boeing H, Chen TA, Steffen B, Steffen LM, Hodge A, Eriksdottir G, Smith AV. 2017. Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies. The Lancet Diabetes & Endocrinology 5 12: 965-974. 2017

Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM et al.. 2017. The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue. Cell Reports 19 12: 2451-2461. 2017

Stancakova Alena, Kuulasmaa Teemu, Kuusisto Johanna, Mohlke Karen L, Collinis Francis S, Boehnke Michael, Laakso Markku. 2017. Genetic risk scores in the prediction of plasma glucose, impaired insulin secretion, insulin resistance and incident type 2 diabetes in the METSIM study. DIABETOLOGIA 60 9: 1722-1730. 2017

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T et al. (incl. Laakso Markku, Lakka Timo, Uusitupa Matti). 2017. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity NATURE GENETICS 50; 2018 1: 26-41. 2017

Westwood S, Liu B, Baird AL, Anand S, Nevado-Holgado AJ, Newby D, Pikkarainen M, Hallikainen M, Kuusisto J, Streffer JR, Novak G, Blennow K, Andreasson U, Zetterberg H, Smith U, Laakso M, Soininen H, Lovestone S. 2017. The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology Alzheimer's research and therapy 9: 31. 2017

Wheeler E, Leong A, Liu CT, Hivert MF, Strawbridge RJ, Podmore C, Li M, Yao J, Sim X, Hong J, Chu AY, Zhang W, Wang X, Chen P, Maruthur NM, Porneala BC, Sharp SJ, Jia Y, Kabagambe EK, Chang LC et al. (incl. Kuusisto J, Laakso M). 2017. Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLOS ONE 14 9: 1002383. 2017

Wood AR, Jonsson A, Jackson AU, Wang N, van Leewen N, Palmer ND, Kobes S, Deelen J, Boquete-Vilarino L, Paananen J, Stancáková A, Boomsma DI, de Geus EJ, Eekhoff EM, Fritsche A, Kramer M, Nijpels G, Simonis-Bik A, van Haeften TW, Mahajan A et al (Incl. Laakso Markku). 2017. A Genome-Wide Association Study of IVGTT-Based Measures of First Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants. DIABETES (NY) 66 8: 2296-2309. 2017

Martiskainen H, Herukka SK, Stancáková A, Paananen J, Soininen H, Kuusisto J, Laakso M, Hiltunen M. 2017. Decreased plasma ß-amyloid in the Alzheimer's disease APP A673T variant carriers. ANNALS OF NEUROLOGY 82 1: 128-132. 2017

Zillikens M Carola, Demissie Serkalem, Hsu Yi-Hsiang, Yerges-Armstrong Laura M, Chou Wen-Chi, Stolk Lisette, Livshits Gregory, Broer Linda, Johnson Toby, Koller Daniel L, Kutalik Zoltán, Luan Jian'an, Malkin Ida, Ried Janina S, Smith Albert V, Thorleifsson Gudmar, Vandenput Liesbeth, Zhao Jing Hua, Zhang Weihua, Aghdassi Ali et al. (incl. Cederberg Henna, Kuulasmaa Teemu, Kuusisto Johanna, Laak. 2017. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nature Communications 8: 80. 2017

Modi S, Yaluri N, Kokkola T, Laakso M. 2017. Plant-derived compounds strigolactone GR24 and pinosylvin activate SIRT1 and enhance glucose uptake in rat skeletal muscle cells. Scientific Reports 7: 17606. 2017

Mardinoglu Adil, Stancáková Alena, Lotta Luca A, Kuusisto Johanna, Boren Jan, Blüher Matthias, Wareham Nicholas J, Ferrannini Ele, Groop Per Henrik, Laakso Markku, Langenberg Claudia, Smith Ulf. 2017. Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease. Cell Metabolism 26 2: 281-283. 2017

Marouli Eirini, Graff Mariaelisa, Medina-Gomez Carolina, Sin Lo Ken, Wood Andrew R, Kjaer Troels R, Fine Rebecca S, Lu Yingchang, Schurmann Claudia, Highland Heather M, Rüeger Sina, Thorleifsson Gudmar, Justice Anne E, Lamparter David, Stirrups Kathleen E, Turcot Valérie, Young Kristin L, Winkler Thomas W, Esko Tõnu, Karaderi Tugce et al. (incl Kuusisto Johanna, Laakso Markku, Lakka Timo A). 2017. Rare and low-frequency coding variants alter human adult height. Nature 542: 186-190. 2017

Jason F, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Tajes JF et al. (incl. Kuulasmaa Teemu, Kuusisto Johanna, Laakso Markku). 2017. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data 4: 170179. 2017

Braenne Ingrid, Zeng Lingyao, Willenborg Christina, Tragante Vinicius, Kessler Thorsten, Willer Cristen J, Laakso Markku, Wallentin Lars, Franks Paul W, Salomaa Veikko, Dehghan Abbas, Meitinger Thomas, Samani Nilesh J, Asselbergs Folkert W, Erdmann Jeanette, Schunkert Heribert, CARDIoGRAM Consortium, CARDIoGRAMplusC4D Consortium. 2017. Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk. PLOS ONE 12 8: e0182999. 2017

Brænne I, Willenborg C, Tragante V, Kessler T, Zeng L, Reiz B, Kleinecke M, von Ameln S, Willer CJ, Laakso M, Wild PS, Zeller T, Wallentin L, Franks PW, Salomaa V, Dehghan A, Meitinger T, Samani NJ, Asselbergs FW, Erdmann J et al.. 2017. A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors. Scientific Reports 7: 10252. 2017

Cai M, Bompada P, Salehi A, Acosta JR, Prasad RB, Atac D, Laakso M, Groop L, De Marinis Y. 2017. Role of osteopontin and its regulation in pancreatic islet. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2018; 495 1: 1426-1431. 2017

Civelek M, Wu Y, Pan C, Raulerson CK, Ko A, He A, Tilford C, Saleem NK, Stancáková A, Scott LJ, Fuchsberger C, Stringham HM, Jackson AU, Narisu N, Chines PS, Small KS, Kuusisto J, Parks BW, Pajukanta P, Kirchgessner T et al. 2017. Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits. AMERICAN JOURNAL OF HUMAN GENETICS 100 3: 428-443. 2017

Davis JP, Huyghe JR, Locke AE, Jackson AU, Sim X, Stringham HM, Teslovich TM, Welch RP, Fuchsberger C, Narisu N, Chines PS, Kangas AJ, Soininen P, Ala-Korpela M, Kuusisto J, Collins FS, Laakso M, Boehnke M, Mohlke KL. 2017. Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study. PLOS GENETICS [ONLINE) 13 10: e1007079. 2017

Fizelova M, Jauhiainen R, Kangas AJ, Soininen P, Ala-Korpela M, Kuusisto J, Laakso M, Stancáková A. 2017. Differential Associations of Inflammatory Markers With Insulin Sensitivity and Secretion: The Prospective METSIM Study. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 102 9: 3600-3609. 2017

Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, Xue L, Workalemahu T, Heard-Costa NL, den Hoed M, Ahluwalia TS, Qi Q, Ngwa JS, Renström F, Quaye L, Eicher JD et al.. 2017. Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLOS GENETICS [ONLINE) 13 4: e1006528. 2017

Cannon ME, Duan Q, Wu Y, Zeynalzadeh M, Xu Z, Kangas AJ, Soininen P, Ala-Korpela M, Civelek M, Lusis AJ, Kuusisto J, Collins FS, Boehnke M, Tang H, Laakso M, Li Y, Mohlke K. 2017. Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus. G3: Genes, genomes, Genetics 7 9: 3217-3227. 2017

Justice Anne E, Winkler Thomas W, Feitosa Mary F, Graff Misa, Fisher Virginia A, Young Kristin, Barata Llilda, Deng Xuan, Czajkowski Jacek, Hadley David, Ngwa Julius S, Ahluwalia Tarunveer S, Chu Audrey Y, Heard-Costa Nancy L, Lim Elise, Perez Jeremiah, Eicher John D, Kutalik Zoltan, Xue Luting, Mahajan Anubha et al.. 2017. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications 8: 14977. 2017

Kraja Aldi T, Cook James P, Warren Helen R, Surendran Praveen, Liu Chunyu, Evangelou Evangelos, Mannig Alisa K, Grarup Niels, Drenos Fotios, Sim Xueling, Smith Albert Vernon, Amin Najaf, Blakemore Alexandra I F, Bork-Jensen Jette, Brandslund Ivan, Farmaki Aliki-Eleni, Fava Cristiano, Ferreira Teresa, Herzig Karl-Heinz, Giri Ayush et al.. 2017. New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals. Circulation: Cardiovascular Genetics 10 5: e001778. 2017

Laakso Markku, Kuusisto Johanna, Stancakova Alena, Kuulasmaa Teemu, Pajukanta Päivi, Jake Lusis Aldons, Collins Francis S, Mohlke Karen, Boehnke Michael. 2017. The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases. JOURNAL OF LIPID RESEARCH 58 3: 481-493. 2017

Laakso Markku, Kuusisto Johanna. 2017. Diabetes secondary to treatment with statins. Current Diabetes Reports 17 2: 1-9. 2017

Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, Di Angelantonio E, Arveiler D, Assimes TL, Auer PL, Baber U, Ballantyne CM, Bang LE, Benn M, Bis JC et al.. 2017. Exome-wide association study of plasma lipids in >300,000 individuals. NATURE GENETICS 49 12: 1758-1766. 2017

Mardinoglu A, Gogg S, Lotta LA, Stancáková A, Nerstedt A, Boren J, Blüher M, Ferrannini E, Langenberg C, Wareham NJ, Laakso M, Smith U. 2017. Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes. EBioMedicine 2018; 27: 151-155. 2017

López Rodríguez M, Kaminska D, Lappalainen K, Pihlajamäki J, Kaikkonen MU, Laakso M. 2017. Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells. Genome Medicine 9: 63. 2017

Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Viñuela A, Brown AA, Wu Y, Flannick J, Fuchsberger C, Gamazon ER, Gaulton KJ, Im HK et al. (incl. Lakka Timo, Kuulasmaa Teemu, Laakso Markku, Uusitupa Matti). 2017. A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. DIABETES (NY) 66 7: 2019-2032. 2017

Kim DS, Jackson AU, Li YK, Stringham HM, FinMetSeq Investigators, Kuusisto J, Kangas AJ, Soininen P, Ala-Korpela M, Burant CF, Salomaa V, Boehnke M, Laakso M, Speliotes EK. 2017. Novel association of TM6SF2 rs58542926 genotype with increased serum tyrosine levels and decreased apoB-100 particles in Finns. JOURNAL OF LIPID RESEARCH 58 7: 1471-1481. 2017

Stancáková A, Laakso M. 2016. Genetics of Type 2 Diabetes. In: Stettler C, Crist E, Diem P (ed.) Novelties in Diabetes. S. karger Vol. 31. s. 203-220. 2016

Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G, Eklund N, Eriksson J, Esko T, Feitosa MF, Goel A, Gorski M, Hayward C, Heard-Costa NL, Jackson AU, Jokinen E, Kanoni S, Kristiansson K et al. 2016. A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nature Communications 7: 13357. 2016

Rodríguez Alejandra, Gonzalez Luis, Ko Arthur, Alvarez Marcus, Miao Zong, Bhagat Yash, Nikkola Elina, Cruz-Bautista Ivette, Arellano-Campos Olimpia, Muñoz-Hernández Linda L, Ordóñez-Sánchez Maria-Luisa, Rodriguez-Guillen Rosario, Mohlke Karen L, Laakso Markku, Tusie-Luna Teresa, Aguilar-Salinas Carlos A, Pajukanta Päivi. 2016. Molecular characterization of the lipid genome-wide association study signal on chromosome 18q11.2 implicates HNF4A-mediated regulation of the TMEM241 gene. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 36 7: 1350-5. 2016

Scott Laura J, Erdos Michael R, Huyghe Jeroen R, Welch Ryan P, Beck Andrew T, Wolford Brooke N, Chines Peter S, Didion John P, Narisu Narisu, Stringham Heather N, Taylor D Leeland, Jackson Anne U, Vadlamudi Swarooparani, Bonnycastle Bonny M, Kinnunen Leena, Saramies Jouko, Sundvall Jouko, D'Oliveira Albanus Ricardo, Kiseleva Anna, Hensley John et al (inc. LakkaTimo A, Laakso Markku). 2016. The genetic regulatory signature of type 2 diabetes in human skeletal muscle Nature Communications 7: 11764. 2016

Scott Robert A, Freitag Daniel F, Li Li, Chu Audrey Y, Surendran Praveen, Young Robin, Grarup Niels, Stancáková Alena, Chen Yuning, Varga Tibor V, Yaghootkar Hanieh, Luan Jian'an, Zhao Jing Hua, Willems Sara M, Wessel Jennifer, Wang Shuai, Maruthur Nisa, Michailidou Kyriaki, Pirie Ailith, van der Lee Sven J et al. 2016. A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease. SCIENCE TRANSLATIONAL MEDICINE 8 341: pp. 341ra76. 2016

Walle Paula, Takkunen Markus, Männistö Ville, Vaittinen Maija, Lankinen Maria, Kärjä Vesa, Käkelä Pirjo, Ågren Jyrki, Tiainen Mika, Schwab Ursula, Kuusisto Johanna, Laakso Markku, Pihlajamäki Jussi. 2016. Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity. METABOLISM 65 5: 655-666. 2016

Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK, Grarup N, Sim X, Barnes DR, Witkowska K, Staley JR, Tragante V, Tukiainen T, Yaghootkar H, Masca N, Freitag DF, Ferreira T, Giannakopoulou O, Tinker A, Harakalova M et al. 2016. Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. NATURE GENETICS 48: 1151-1161. 2016

Vangipurapu Jagadish, Stancakova Alena, Jauhiainen Raimo, Kuusisto Johanna, Laakso Markku. 2016. Short adult stature predicts impaired beta-cell function, insulin resistance, glycemia and type 2 diabetes in Finnish men Journal of clinical endocrinology and metabolism 2017: 102 2: 443-450. 2016

Walford GA, Gustafsson S, Rybin D, Stancáková A, Chen H, Liu CT, Hong J, Jensen RA, Rice K, Morris AP, Mägi R, Tönjes A, Prokopenko I, Kleber ME, Delgado G, Silbernagel G, Jackson AU, Appel EV, Grarup N, Lewis JP et al.. 2016. Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci. DIABETES (NY) 65 10: 3200-3211. 2016

Winkler Thomas W, Justice Anne E, Graff Mariaelisa, Barata Llilda, Feitosa Mary F, Chu Su, Czajkowski Jacek, Esko Tõnu, Fall Tove, Kilpeläinen Tuomas O, Lu Yingchang, Mägi Reedik, Mihailov Evelin, Pers Tune H, Rüeger Sina, Teumer Alexander, Ehret Georg B, Ferreira Teresa, Heard-Costa Nancy L, Karjalainen Juha et al. 2016. Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLOS GENETICS [ONLINE) 12 6: e1006166. 2016

Zanoni Paolo, Khetarpal Sumeet A, Larach Daniel B, Hancock-Cerutti William F, Millar John S, Cuchel Marina, DerOhannessian Stephanie, Kontush Anatol, Surendran Praveen, Saleheen Danish, Trompet Stella, Jukema J Wouter, De Craen Anton, Deloukas Panos, Sattar Naveed, Ford Ian, Packard Chris, Majumder Abdullah al Shafi , Alam Dewan S, Di Angelantonio Emanuele et al. 2016. Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. SCIENCE 351 6278: 1166-1171. 2016

Minikel Eric Vallabh, Vallabh Sonia M, Lek Monkol, Estrada Karol, Samocha Kaitlin E, Sathirapongsasuti J Fah, McLean Cory Y, Tung Joyce Y, Yu Linda PC, Gambetti Pierluigi, Blevins Janis, Zhang Shulin, Cohen Yvonne, Chen Wei, Yamada Masahito, Hamaguchi Tsuyoshi, Sanjo Nobuo, Mizusawa Hidehiro, Nakamura Yosikazu, Kitamoto Tetsuyuki et al. 2016. Quantifying prion disease penetrance using large population control cohorts. SCIENCE TRANSLATIONAL MEDICINE 8 322: 322ra9. 2016

Pattaro Christian, Teumer Alexander, Gorski Mathias, Chu Audrey Y, Li Man, Mijatovic Vladan, Garnaas Maija, Tin Adrienne, Sorice Rossella, Li Yong, Taliun Daniel, Olden Matthias, Foster Meredith, Yang Qiong, Chen Ming-Huei, Pers Tune H, Johnson Andrew D, Ko Yi-An, Fuchsberger Christian, Tayo Bamiele et al.. 2016. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nature Communications 7: 10023. 2016

Li M, Li Y, Weeks O, Mijatovic V, Teumer A, Huffman JE, Tromp G, Fuchsberger C, Gorski M, Lyytikäinen LP, Nutile T, Sedaghat S, Sorice R, Tin A, Yang Q, Ahluwalia TS, Arking DE, Bihlmeyer NA, Böger CA, Carroll RJ et al.. 2016. SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2017; 28 3: 981-994. 2016

Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, Steinberg WM, Stockner M, Zinman B, Bergenstal RM, Buse JB, LEADER Steering Committee, LEADER Trial Investigators. 2016. Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes. NEW ENGLAND JOURNAL OF MEDICINE 375 4: 311-322. 2016

Huopio Hanna, Miettinen Päivi J, Ilonen Jorma, Nykänen Päivi, Veijola Riitta, Keskinen Päivi, Näntö-Salonen Kirsti, Vangipurapu Jagadish, Raivo Joose, Stancáková Alena, Männistö Jonna, Kuulasmaa Teemu, Knip Mikael, Otonkoski Timo, Laakso Markku. 2016. Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 101 8: 3018-3026. 2016

Löf Christoffer, Patyra Konrad, Kuulasmaa Teemu, Vangipurapu Jagadish, Undeutsch Henriette, Jäschke Holger, Pajunen Tuulia, Kero Andreina, Krude Heiko, Biebermann Heike, Kleinau Gunnar, Kühnen Peter, Rantakari Krista, Miettinen Päivi, Kirjavainen Turkka, Pursiheimo Juha-Pekka, Mustila Taina, Jääskeläinen Jarmo, Ojaniemi Marja, Toppari Jorma et al. 2016. Detection of novel gene variants associated with congenital hypothyroidism in a Finnish patient cohort. THYROID 26 9: 1215-1224. 2016

De Marinis Yang, Cai Mengyin, Bompada Pradeep, Atac David, Kotova Olga, Johansson Martin E, Garcia-Vaz Eliana, Gomez Maria F, Laakso Markku, Groop Leif. 2016. Epigenetic regulation of the thioredoxin-interacting protein (TXNIP) gene by hyperglycemia in kidney. KIDNEY INTERNATIONAL 89 2: 342-353. 2016

Ehret GB, Ferreira T, Chasman DI, Jackson AU, Schmidt EM, Johnson T, Thorleifsson G, Luan J, Donnelly LA, Kanoni S, Petersen AK, Pihur V, Strawbridge RJ, Shungin D, Hughes MF, Meirelles O, Kaakinen M, Bouatia-Naji N, Kristiansson K, Shah S et al.. 2016. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. NATURE GENETICS 48 10: 1171-1184. 2016

Fizelova Maria, Jauhiainen Raimo, Stancáková Alena, Kuusisto Johanna, Laakso Markku. 2016. Finnish Diabetes Risk Score Is Associated with Impaired Insulin Secretion and Insulin Sensitivity, Drug-Treated Hypertension and Cardiovascular Disease: A Follow-Up Study of the METSIM Cohort. PLOS ONE 11 11: e0166584. 2016

Gusev Alexander, Ko Arthur, Shi Huwendo, Bhatia Gaurav, Chung Wonil, Penninx Brenda WJH, Jansen Rick, de Geus Eco JC, Boomsma Dorret I, Wright Fred A, Sullivan Patrick F, Nikkola Elina, Alvarez Marcus, Civelek Mete, Lusis Aldons J, Lehtimäki Terho, Raitoharju Emma, Kähönen Mika, Seppälä Ilkka, Raitakari Olli T et al. 2016. Integrative approaches for large-scale transcriptome-wide association studies. NATURE GENETICS 48: 245-252. 2016

Fuchsberger Christian, Flannick Jason, Teslovich Tanya M, Mahajan Anubha, Agarwala Vineeta, Gaulton Kyle J, Ma Clement, Fontanillas Pierre, Moutsianas Loukas, McCarthy Davis J, Rivas Manuel A, Perry John RB, Sim Xueling, Blackwell Thomas W, Robertson Neil R, Rayner N William, Cingolani Pablo, Locke Adam E, Tajes Juan Fernandes, Highland Heather M, (incl Kuulasmaa Teemu). 2016. The genetic architecture of type 2 diabetes. NATURE (LONDON) 536: 41-47. 2016

Jalanko Mikko, Tarkiainen Mika, Sipola Petri, Jääskeläinen Pertti, Lauerma Kirsi, Laine Mika, Nieminen Markku S, Laakso Markku, Heliö Tiina, Kuusisto Johanna. 2016. Left ventricular mechanical dispersion is associated with nonsustained ventricular tachycardia in hypertrophic cardiomyopathy. Annals of Medicine: 2016 Jun 1:1-11. [Epub ahead of print]. 2016

Kaminska Dorota, Käkelä Pirjo, Nikkola Elina, Venesmaa Sari, Ilves Imre, Herzig Karl-Heinz, Kolehmainen Marjukka, Karhunen Leila, Kuusisto Johanna, Gylling Helena, Pajukanta Päivi, Laakso Markku, Pihlajamäki Jussi. 2016. Regulation of alternative splicing in human obesity loci Obesity 24 10: 2033-2037. 2016

Laakso Markku, Groop Leif, Honkasalo Mikko, Isomaa Bo, Juselius Päivi, Lindström Jaana, Meinander Tuula, Nuutinen Helena, Saltevo Juha, Syvänne Mikko, Tuomi Tiinamaija. 2016. Diabetes. DUODECIM 132 9: 881-882. 2016

Lee Sunjae, Zhang Cheng, Kilicarslan Murat, Piening Brian D, Bjornson Elias, Hallström Björn M, Groen Albert K, Ferrannini Ele, Laakso Markku, Snyder Michael, Blüher Matthias, Uhlen Mathias, Nielsen Jens, Smith Ulf, Serlie Mireille J, Boren Jan, Mardinoglu Adil. 2016. Integrated network analysis reveals an association between plasma mannose levels and insulin resistance. Cell Metabolism 24 1: 172-84. 2016

Lek M, Karczewski KJ, Minikel EV, Samocha KE, Banks E, Fennell T, O'Donnell-Luria AH, Ware JS, Hill AJ, Cummings BB, Tukiainen T, Birnbaum DP, Kosmicki JA, Duncan LE, Estrada K, Zhao F, Zou J, Pierce-Hoffman E, Berghout J, Cooper DN et al. 2016. Analysis of protein-coding genetic variation in 60,706 humans. NATURE (LONDON) 536: 285-291. 2016

Lu Yingchang, Day Felix R, Gustafsson Stefan, Buchkovich Martin L, Na Jianbo, Bataille Veronique, Cousminer Diana L, Dastani Zari, Drong Alexander W, Esko Tönu, Evans David M, Falchi Mario, Feitosa Mary F, Ferreira Teresa, Hedman Åsa K, Haring Robin, Hysi Pirro G, Iles Mark M, Justice Anne E, Kanoni Stavroula et al. 2016. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature Communications 7: 10495. 2016

Rebelos Eleni, Seghieri Marta, Natali Andrea, Balkau Beverly, Golay Alain, Piatti Pier Marco, Lalic Nebojsa M, Laakso Markku, Mari Andrea, Ferrannini Ele. 2015. Influence of endogenous NEFA on beta cell function in humans. DIABETOLOGIA 58 10: 2344-2351. 2015

Mahajan Anubha, Sim Xueling, Ng Hui Jin, Manning Alisa, Rivas Manuel A, Highland Heather M, Locke Adam E, Grarup Niels, Im Hae Kyung, Cingolani Pablo, Flannick Jason, Fontanillas Pierre, Fuchsberger Christian, Gaulton Kyle J, Teslovich Tanya M, Rayner N William, Robertson Neil R, Beer Nicola L, Rundle Jana K, Bork-Jensen Jette et al. On Behalf of the T2D-GENES consortium and GoT2D consortium. 2015. Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus. PLOS GENETICS [ONLINE) 11 1: e1004876. 2015

Mäkelä J, Lagström H, Pitkänen N, Kuulasmaa T, Kaljonen A, Laakso M, Niinikoski H. 2015. Genetic risk clustering increases children's body weight at 2 years of age - the STEPS Study. PEDIATRIC OBESITY [epub ahead of print 11 Dec 2015]: -. 2015

Panduru Nicolae M, Saraheimo Markku, Forsblom Carol, Thorn Lena M, Gordin Daniel, Wadén Johan, Tolonen Nina, Bierhaus Angelika, Humpert Per M, Groop Per-Henrik on behalf of the FinnDiane Study Group (incl. Markku Laakso). 2015. Urinary adiponectin is an independent predictor of progression to end-stage renal disease in patients with type 1 diabetes and diabetic nephropathy. DIABETES CARE 38 5: 883-90. 2015

Pers Tune H, Karjalainen Juha M, Chan Yingleong, Westra Harm-Jan, Wood Andrew R, Yang Jian, Lui Julian C, Vedantam Sailaja, Gustafsson Stefan, Esko Tonu, Frayling Tim, Speliotes Elizabeth K, Genetic Investigation of ANthropometric Traits (GIANT) Consortium (incl. Johanna Kuusisto, Markku Laakso, Timo Lakka, Matti Uusitupa), Boehnke Michael, Raychaudhuri Soumya, Fehrmann Rudolf SN, Hirschhorn Joel . 2015. Biological interpretation of genome-wide association studies using predicted gene functions. Nature Communications 6: 5890. 2015

Pihlajamäki Jussi, Schwab Ursula, Kaminska Dorota, Ågren Jyrki, Kuusisto Johanna, Kolehmainen Marjukka, Paananen Jussi, Laakso Markku, Uusitupa Matti. 2015. Dietary polyunsaturated fatty acids and the Pro12Ala polymorphisms of PPARG regulate serum lipids through divergent pathways: a randomized crossover clinical trial. Genes and Nutrition 10 6: 43. 2015

Yaluri Nagendra, Modi Shalem, López Rodríguez Maykel, Stancáková Alena, Kuusisto Johanna, Kokkola Tarja, Laakso Markku. 2015. Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells. PLOS ONE [ONLINE] 10 11: e0142902. 2015

Roman Tamara S, Marvelle Amanda F, Fogarty Marie P, Vadlamudi Swarooparani, Gonzalez Arlene J, Buchkovich Martin L, Huyghe Jeroen R, Fuchsberger Christian, Jackson Anne U, Wu Ying, Civelek Mete, Lusis Aldons J, Gaulton Kyle J, Sethupathy Praveen, Kangas Antti J, Soininen Pasi, Ala-Korpela Mika, Kuusisto Johanna, Collins Francis S, Laakso Markku, Boehnke Michael, Mohlke Karen L.. 2015. Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol. AMERICAN JOURNAL OF HUMAN GENETICS 97 6: 801-815. 2015

Shungin Dmitry, Winkler Thomas W, Croteau-Chonka Damien C, Ferreira Teresa, Locke Adam E, Mägi Reedik, Strawbridge Rona J, Pers Tune H, Fischer Krista, Justice Anne E, Workalemahu Tsegaselassie, Wu Joseph MW, Buchkovich Martin L, Heard-Costa Nancy L, Roman Tamara S, Drong Alexander W, Song Ci, Gustafsson Stefan, Day Felix R, Esko Tonu et al. 2015. New genetic loci link adipose and insulin biology to body fat distribution. NATURE (LONDON) 518 7538: 187-196. 2015

Takkunen Markus J, de Mello Vanessa D, Schwab Ursula S, Kuusisto Johanna, Vaittinen Maija, Ågren Jyrki J, Laakso Markku, Pihlajamäki Jussi, Uusitupa MI. 2015. Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men. Molecular Nutrition & Food Research 2016; 60 2: 381-389. 2015

Vangipurapu Jagadish, Stancáková Alena, Kuulasmaa Teemu, Kuusisto Johanna, Laakso Markku. 2015. Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 finnish men. PLOS ONE [ONLINE] 10 4: e0124028. 2015

Wessel Jennifer, Chu Audrey Y, Willems Sara M, Wang Shuai, Yaghootkar Hanieh, Brody Jennifer A, Dauriz Marco, Hivert Marie-France, Raghavan Sridharan, Lipovich Leonard, Hidalgo Bertha, Fox Keolu, Huffman Jennifer E, An Ping, Lu Yingchang, Rasmussen-Torvik Laura J, Grarup Niels, Ehm Margaret G, Li Li, Baldridge Abigail S et al. 2015. Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nature Communications 6: 5897. 2015

Winkler Thomas W, Justice Anne E, Graff Mariaelisa, Barata Llilda, Feitosa Mary F, Chu Su, Czajkowski Jacek, Esko Tõnu, Fall Tove, Kilpeläinen Tuomas O, Lu Yingchang, Mägi Reedik, Mihailov Evelin, Pers Tune H, Rüeger Sina, Teumer Alexander, Ehret Georg B, Ferreira Teresa, Heard-Costa Nancy L, Karjalainen Juha et al. 2015. The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLOS GENETICS [ONLINE) 11 10: e1005378. 2015

Yaghootkar Hanieh, Stancáková Alena, Freathy Rachel M, Vangipurapu Jagadish, Weedon Michael N, Xie Weijia, Wood Andrew R, Ferrannini Ele, Mari Andrea, Ring Susan M, Lawlor Debbie A, Smith George Davey, Jørgensen Torben, Hansen Torben, Pedersen Oluf, Steinthorsdottir Valgerdur, Guðbjartsson Daniel F, Thorleifsson Gudmar, Thorsteinsdottir Unnur, Stefansson Kari et al. 2015. Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion. DIABETES (NY) 64 6: 2279-2285. 2015

Locke Adam E, Kahali Bratati, Berndt Sonja I, Justice Anne E, Pers Tune H, Day Felix R, Powell Corey, Vedantam Sailaja, Buchkovich Martin L, Yang Jian, Croteau-Chonka Damien C, Esko Tonu, Fall Tove, Ferreira Teresa, Gustafsson Stefan, Kutalik Zoltán, Luan Jian'an, Mägi Reedik, Randall Joshua C, Winkler Thomas W et al. 2015. Genetic studies of body mass index yield new insights for obesity biology. NATURE (LONDON) 518 7538: 197-206. 2015

Lankinen Maria A, Stancáková Alena, Uusitupa Matti, Ågren Jyrki, Pihlajamäki Jussi, Kuusisto Johanna, Schwab Ursula, Laakso Markku. 2015. Plasma fatty acids as predictors of glycaemia and type 2 diabetes. DIABETOLOGIA 58 11: 2533-2544. 2015

Laakso Markku. 2015. Is Insulin Resistance a Feature of or a Primary Risk Factor for Cardiovascular Disease?. Current Diabetes Reports 15 105: 1-9. 2015

Christopher P. Nelson, Stephen E. Hamby, Danish Saleheen, Jenna C. Hopewell, Lingyao Zeng, Themistocles L. Assimes, Stavroula Kanoni, Christina Willenborg, Stephen Burgess, Phillipe Amouyel, Sonia Anand, Stefan Blankenberg, Bernhard O. Boehm, Robert J. Clarke, Rory Collins, George Dedoussis, Martin Farrall, Paul W. Franks, Leif Groop, Alistair S. Hall et al. for the CARDIoGRAM+C4D Consortium (inic. 2015. Genetically determined height and coronary artery disease. NEW ENGLAND JOURNAL OF MEDICINE 372: 1608-1618. 2015

Laakso Markku, Rosenstock Julio, Groop Per-Henrik, Barnett Anthony H, Gallwitz Baptist, Hehnke Uwe, Tamminen Ilkka, Patel Sanjay, Von Eynatten Maximilian, Woerle Hans-Juergen. 2015. Treatment with the dipeptidyl peptidase-4 inhibitor linagliptin or placebo followed by glimepiride in patients with type 2 diabetes with moderate to severe renal impairment: a 52-week, randomized, double-blind clinical trial. DIABETES CARE 38 2: e15-e17. 2015

Berglund Lisa M, Lyssenko Valeriya, Ladenvall Claes, Kotova Olga, Edsfeldt Andreas, Pilgaard Kasper, Alkayyali Sami, Brøns Charlotte, Forsblom Carol, Jonsson Anna, Zetterqvist Anna V, Nitulescu Mihaela, McDavitt Christian Ruiz, Dunér Pontus, Stancáková Alena, Kuusisto Johanna, Ahlqvist Emma, Lajer Maria, Tarnow Lise, Madsbad Sten et al. 2015. Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB. DIABETES (NY) (2016) 65 1: 239-254. 2015

Cai M, Bompada P, Atac D, Laakso M, Groop L, De Marinis Y. 2015. Epigenetic regulation of glucose-stimulated osteopontin (OPN) expression in diabetic kidney. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2016; 469 1: 108-113. 2015

Cederberg Henna, Laakso Markku. 2015. Type 2 diabetes mellitus and dyslipidemia. In: Abhimanyu Garg (ed.) Dyslipidemias : Pathophysiology, Evaluation and Management. Humana press. s. 99-113. 2015

Cederberg Henna, Laakso Markku. 2015. Variable effects of statins on glucose homeostasis parameters and their diabetogenic role. Reply to Kostapanos MS, Agouridis AP and Elisaf MS [letter. DIABETOLOGIA 58 8: 1962-3. 2015

Cederberg Henna, Stancáková Alena, Yaluri Nagendra, Modi Shalem, Kuusisto Johanna, Laakso Markku. 2015. Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort. DIABETOLOGIA 58 5: 1109-1117. 2015

Alastalo Tero-Pekka, West Gun, Li Song-Ping, Keinänen Anni, Helenius Mikko, Tyni Tiina, Lapatto Risto, Turanlahti Maila, Heikkilä Päivi, Kääriäinen Helena, Laakso Markku, Mauermann Monika, Herrmann Harald, Pihkala Jaana, Taimen Pekka. 2015. LMNA Mutation c.917T>G (p.L306R) Leads to Deleterious Hyper-Assembly of Lamin A/C and Associates with Severe Right Ventricular Cardiomyopathy and Premature Aging. HUMAN MUTATION 36 7: 694-703. 2015

Fizelova Maria, Miilunpohja Manna, Kangas Antti J, Soininen Pasi, Kuusisto Johanna, Ala-Korpela Mika, Laakso Markku, Stancáková Alena. 2015. Associations of multiple lipoprotein and apolipoprotein measures with worsening of glycemia and incident type 2 diabetes in 6607 non-diabetic Finnish men. ATHEROSCLEROSIS 240 1: 272-277. 2015

Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, William Rayner N, Robertson N, Scott RA, Prokopenko I, Scott LJ, Green T, Sparso T, Thuillier D, Yengo L, Grallert H, Wahl S, Frånberg M et al.. 2015. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. NATURE GENETICS 47: 1415-1425. 2015

Jorgenrud Benedicte, Jalanko Mikko, Heliö Tiina, Jääskeläinen Pertti, Laine Mika, Hilvo Mika, Nieminen Markku S., Laakso Markku, Hyötyläinen Tuulia, Oresic Matej, Kuusisto Johanna. 2015. The Metabolome in Finnish Carriers of the MYBPC3-Q1061X Mutation for Hypertrophic Cardiomyopathy. PLOS ONE [ONLINE] 10 8: e0134184. 2015

Joshi Peter K, Esko Tonu, Mattsson Hannele, Eklund Niina, Gandin Ilaria, Nutile Teresa, Jackson Anne U, Schurmann Claudia, Smith Albert V, Zhang Weihua, Okada Yukinori, Stancáková Alena, Faul Jessica D, Zhao Wei, Bartz Traci M, Pina Concas Maria, Franceschini Nora, Enroth Stefan, Vitart Veronique, Trompet Stella et al (incl. Kuusisto Johanna, Laakso Markku). 2015. Directional dominance on stature and cognition in diverse human populations. NATURE (LONDON) 523: 459-462. 2015

Kim Young Jin, Lee Juyoung, Kim Bong-Jo, Park Taesung, T2D-Genes Consortium (incl. Laakso Markku). 2015. A new strategy for enhancing imputation quality of rare variants from next-generation sequencing data via combining SNP and exome chip data. BMC GENOMICS [ONLINE:HTTP://WWW.BIOMEDCENTRAL.COM/BMCGENOMICS/] 16: 1109. 2015

Knowles Joshua W, Xie Weijia, Zhang Zhongyang, Chennemsetty Indumathi, Assimes Themistocles L, Paananen Jussi, Hansson Ola, Pankow James, Goodarzi Mark O, Carcamo-Orive Ivan, Morris Andrew P, Chen Yii-Der I, Mäkinen Ville-Petteri, Ganna Andrea, Mahajan Anubha, Guo Xiuqing, Abbasi Fahim, Greenawalt Danielle M, Lum Pek, Molony Cliona et al. 2015. Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. JOURNAL OF CLINICAL INVESTIGATION 125 4: 1739-1751. 2015

Fizelova Maria, Stancáková Alena, Lorenzo Carlos, Haffner Steven M, Cederberg Henna, Kuusisto Johanna, Laakso Markku. 2015. Glycated hemoglobin levels are mostly dependent on nonglycemic parameters in 9398 Finnish men without diabetes. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 100 5: 1989-1996. 2015

Rahmioglu Nilufer, Macgregor Stuart, Drong Alexander W, Hedman Åsa K, Harris Holly R, Randall Joshua C, Prokopenko Inga, The International EndoGene Consortium (IEC), The GIANT Consortium, Nyholt Dale R, Morris Andrew P, Montgomery Grant W, Missmer Stacey A, Lindgren Cecilia M, Zondervan Krina T. 2014. Genome-wide Enrichment Analysis between Endometriosis and Obesity-related Traits Reveals Novel Susceptibility Loci. HUMAN MOLECULAR GENETICS Epub ahead of print: -. 2014

Lorenzo Carlos, Haffner Steven M, Stancáková Alena, Kuusisto Johanna, Laakso Markku. 2014. Fasting and OGTT-derived measures of insulin resistance as compared with the euglycemic-hyperinsulinemic clamp in non-diabetic Finnish offspring of type 2 diabetic individuals. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 2015; 100 2: 544-550. 2014

Majithia Amit R, Flannick Jason, Shahinian Peter, Guo Michael, Bray Mark-Anthony, Fontanillas Pierre, Gabriel Stacey B, GoT2D Consortium, NHGRI JHS/FHS Allelic Spectrum Project, SIGMA T2D Consortium, T2D-GENES Consortium, Rosen Evan D, Altshuler David (including Laakso Markku). 2014. Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111 36: 13127-13132. 2014

Männistö Ville T, Simonen Marko, Hyysalo Jenni, Soininen Pasi, Kangas Antti J, Kaminska Dorota, Matte Ananda K, Venesmaa Sari, Käkelä Pirjo, Kärjä Vesa, Arola Johanna, Gylling Helena, Cederberg Henna, Kuusisto Johanna, Laakso Markku, Yki-Järvinen Hannele, Ala-Korpela Mika, Pihlajamäki Jussi. 2014. Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans. Liver International 2015; 35 7: 1853-1861. 2014

Ng MC, Shriner D, Chen BH, Li J, Chen WM, Guo X, Liu J, Bielinski SJ, Yanek LR, Nalls MA, Comeau ME, Rasmussen-Torvik LJ, Jensen RA, Evans DS, Sun YV, An P, Patel SR, Lu Y, Long J, Armstrong LL et al. (including Kuusisto J, Laakso M). 2014. Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. PLOS GENETICS [ONLINE) 10 8: e1004517. 2014

Prokopenko Inga, Poon Wenny, Mägi Reedik, Prasad BR, Salehi S Albert, Almgren Peter, Osmark Peter, Bouatia-Naji Nabila, Wierup Nils, Fall Tove, Stancáková Alena, Barker Adam, Lagou Vasiliki, Osmond Clive, Xie Weijia, Lahti Jari, Jackson Anne U, Cheng Yu-Ching, Liu Jie, O'Connell Jeffrey R et al. (including Kuusisto Johanna, Laakso Markku, Lakka Timo). 2014. A Central Role for GRB10 in Regulation of Islet Function in Man. PLOS GENETICS [ONLINE) 10 4: e1004235. 2014

Vepsäläinen Teemu, Laakso Markku, Lehto Seppo, Juutilainen Auni, Airaksinen Juhani, Rönnemaa Tapani. 2014. Prolonged P wave duration predicts stroke mortality among type 2 diabetic patients with prevalent non-major macrovascular disease. BMC CARDIOVASCULAR DISORDERS [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/1471-2261/] 14: 168. 2014

SIGMA Type 2 Diabetes Consortium, Williams AL, Jacobs SB, Moreno-Macías H, Huerta-Chagoya A, Churchhouse C, Márquez-Luna C, García-Ortíz H, Gómez-Vázquez MJ, Burtt NP, Aguilar-Salinas CA, González-Villalpando C, Florez JC, Orozco L, Haiman CA, Tusié-Luna T, Altshuler D (including Laakso M). 2014. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. NATURE (LONDON) 506 6: 97-101. 2014

Stancakova A, Laakso M. 2014. Genetics of metabolic syndrome. REVIEWS IN ENDOCRINE AND METABOLIC DISORDERS 15 4: 243-252. 2014

Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 25 6: 634-641. 2014

Winkler Thomas W, Day Felix R, Croteau-Chonka Damien C, Wood Andrew R, Locke Adam E, Mägi Reedik, Ferreira Teresa, Fall Tove, Graff Mariaelisa, Justice Anne E, Luan Jian'an, Gustafsson Stefan, Randall Joshua C, Vedantam Sailaja, Workalemahu Tsegaselassie, Kilpeläinen Tuomas O, Scherag André, Esko Tonu, Kutalik Zoltán, Heid Iris M, The Genetic Investigation of Anthropometric Traits (GIANT) Consorti. 2014. Quality control and conduct of genome-wide association meta-analyses. NATURE PROTOCOLS 9 5: 1192-1212. 2014

Wood Andrew R, Esko Tonu, Yang Jian, Vedantam Sailaja, Pers Tune H, Gustafsson Stefan, Chu Audrey Y, Estrada Karol, Luan Jian'an, Kutalik Zoltán, Amin Najaf, Buchkovich Martin L, Croteau-Chonka Damien C, Day Felix R, Duan Yanan, Fall Tove, Fehrmann Rudolf, Ferreira Teresa, Jackson Anne U, Karjalainen Juha et.al.. 2014. Defining the role of common variation in the genomic and biological architecture of adult human height. NATURE GENETICS 46 11: 1173-86. 2014

Lim Elaine T, Würtz Peter, Havulinna Aki S, Palta Priit, Tukiainen Taru, Rehnström Karola, Esko Tõnu, Mägi Reedik, Inouye Michael, Lappalainen Tuuli, Chan Yingleong, Salem Ranu M, Lek Monkol, Flannick Jason, Sim Xueling, Manning Alisa, Ladenvall Claes, Bumpstead Suzannah, Hämäläinen Eija, Aalto Kristiina et al., (including Laakso Markku). 2014. Distribution and medical impact of loss-of-function variants in the Finnish founder population. PLOS GENETICS [ONLINE) 10 7: e1004494. 2014

Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR, Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu J, Li G, Ruiz-Narvaez EA, Chen WM et al. (including Kuusisto J, Laakso M). 2014. Multi-ethnic fine-mapping of 14 central adiposity loci. HUMAN MOLECULAR GENETICS 23 17: 4738-4744. 2014

Koivula RW, Heggie A, Barnett A, Cederberg H, Hansen TH, Koopman AD, Ridderstråle M, Rutters F, Vestergaard H, Gupta R, Herrgård S, Heymans MW, Perry MH, Rauh S, Siloaho M, Teare HJ, Thorand B, Bell J, Brunak S, Frost G, et al. (including Laakso M). 2014. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium. DIABETOLOGIA 57 6: 1132-1142. 2014

Laakso Markku, Kuusisto Johanna. 2014. Insulin resistance and hyperglycaemia in cardiovascular disease development. NATURE REVIEWS ENDOCRINOLOGY 10: 293-302. 2014

Flannick Jason, Thorleifsson Gudmar, Beer Nicola L, Jacobs Suzanne BR, Grarup Niels, Burtt Noël P, Mahajan Anubha, Fuchsberger Christian, Atzmon Gil, Benediktsson Rafn, Blangero John, Bowden Don W, Brandslund Ivan, Brosnan Julia, Burslem Frank, Chambers John, Cho Yoon Shin, Christensen Cramer, Douglas Desirée A, Duggirala Ravindranath et al. (including Laakso Markku). 2014. Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. NATURE GENETICS 46 4: 357-363. 2014

Kulzer JR, Stitzel ML, Morken MA, Huyghe JR, Fuchsberger C, Kuusisto J, Laakso M, Boehnke M, Collins FS, Mohlke KL. 2014. A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell. AMERICAN JOURNAL OF HUMAN GENETICS 94 2: 186-197. 2014

Cederberg Henna, Stancakova Alena, Kuusisto Johanna, Laakso Markku, Smith Ulf. 2014. Family history of type 2 diabetes increases the risk of both obesity and its complications: is type 2 diabetes a disease of inappropriate lipid storage?. JOURNAL OF INTERNAL MEDICINE 277 5: 540-551. 2014

Claussnitzer Melina, Dankel Simon N, Klocke Bernward, Grallert Harald, Glunk Viktoria, Berulava Tea, Lee Heekyoung, Oskolkov Nikolay, Fadista Joao, Ehlers Kerstin, Wahl Simone, Hoffmann Christoph, Qian Kun, Rönn Tina, Riess Helene, Müller-Nurasyid Martina, Bretschneider Nancy, Schroeder Timm, Skurk Thomas, Horsthemke Bernhard et al. (including Kuusisto Johanna, Laakso Markku). 2014. Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms. CELL 156 1-2: 343-358. 2014

Dimas Antigone S, Lagou Vasiliki, Barker Adam, Knowles Joshua W, Mägi Reedik, Hivert Marie-France, Benazzo Andrea, Rybin Denis, Jackson Anne U, Stringham Heather M, Song Ci, Fischer-Rosinsky Antje, Boesgaard Trine Wellöw, Grarup Niels, Abbasi Fahim A, Assimes Themistocles L, Hao Ke, Yang Xia, Lecoeur Cécile, Barroso Inês et al (including Kuusisto Johanna, Laakso Markku). 2014. Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. DIABETES (NY) 63 6: 2158-2171. 2014

Fízelóvá Maria, Cederberg Henna, Stancakova Alena, Jauhiainen Raimo, Vangipurapu Jagadish, Kuusisto Johanna, Laakso Markku. 2014. Markers of tissue-specific insulin resistance predict the worsening of hyperglycemia, incident type 2 diabetes and cardiovascular disease. PLOS ONE [ONLINE] 9 10: e109772. 2014

Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium, Mahajan A, Go MJ, Zhang W, Below JE, Gault. 2014. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.. NATURE GENETICS 46 3: 234-244. 2014

Ganesh SK, Chasman D, Larson MG, Guo X, Verwoert G, Bis JC, Gu X, Smith AV, Yang ML, Zhang Y, Ehret G, Rose LM, Hwang SJ, Papanicolau GJ, Sijbrands EJ, Rice K, Eiriksdottir G, Pihur V, Ridker PM, Vasan RS (including Kuusisto J, Laakso M). 2014. Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. AMERICAN JOURNAL OF HUMAN GENETICS 95 1: 49-65. 2014

Hara Kazuo, Fujita Hayato, Johnson Todd A, Yamauchi Toshimasa, Yasuda Kazuki, Horikoshi Momoko, Peng Chen, Hu Cheng, Ma Ronald CW, Imamura Minako, Iwata Minoru, Tsunoda Tatsuhiko, Morizono Takashi, Shojima Nobuhiro, So Wing Yee, Leung Ting Fan, Kwan Patrick, Zhang Rong, Wang Jie, Yu Weihui et al. (including Kuusisto Johanna, Laakso Markku). 2014. Genome-wide association study identifies three novel loci for type 2 diabetes. HUMAN MOLECULAR GENETICS 23 1: 239-246. 2014

Herrmann Markus, Sullivan David R, Veillard Anne-Sophie, McCorquodale Thomas, Straub Isabella R, Scott Russell, Laakso Markku, Topliss Duncan, Jenkins Alicia J, Blankenberg Stefan, Burton Anthony, Keech Anthony C for the FIELD study investigators. 2014. Serum 25-Hydroxyvitamin D: A Predictor of Macrovascular and Microvascular Complications in Patients With Type 2 Diabetes. DIABETES CARE 38 3: 521-528. 2014

Hoggart Clive J, Venturini Giulia, Mangino Massimo, Gomez Felicia, Ascari Giulia, Zhao Jing Hua, Teumer Alexander, Winkler Thomas W, Tšernikova Natalia, Luan Jian'an, Mihailov Evelin, Ehret Georg B, Zhang Weihua, Lamparter David, Esko Tõnu, Macé Aurelian, Rüeger Sina, Bochud Pierre-Yves, Barcella Matteo, Dauvilliers Yves et al (including Atalay Mustafa, Kuusisto Johanna, Lakka Timo, Yaluri Alena, . 2014. Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index. PLOS GENETICS [ONLINE) 10 7: e1004508. 2014

Jääskeläinen Pertti, Heliö Tiina, Aalto-Setälä Katriina, Kaartinen Maija, Ilveskoski Erkki, Hämäläinen Liisa, Melin John, Kärkkäinen Satu, Peuhkurinen Keijo, Nieminen Markku S, Laakso Markku, the FinHCM MStudy Group, Kuusisto Johanna. 2014. A new common mutation in the cardiac beta-myosin heavy chain gene in Finnish patients with hypertrophic cardiomyopathy. Annals of Medicine 46: 424-429. 2014

Andersen GS, Thybo T, Cederberg H, Oresic M, Esteller M, Zorzano A, Carr B, Walker M, Cobb J, Clissmann C, O'Gorman DJ, Nolan JJ, on behalf of the DEXLIFE Consortium (including Laakso M). 2014. The DEXLIFE study methods: Identifying novel candidate biomarkers that predict progression to type 2 diabetes in high risk individuals. DIABETES RESEARCH AND CLINICAL PRACTICE 106 2: 383-389. 2014

Sim X, Jensen RA, Ikram MK, Cotch MF, Li X, MacGregor S, Xie J, Smith AV, Boerwinkle E, Mitchell P, Klein R, Klein BE, Glazer NL, Lumley T, McKnight B, Psaty BM, de Jong PT, Hofman A, Rivadeneira F, Uitterlinden AG et al (including M Laakso, J Kuusisto). 2013. Genetic Loci for Retinal Arteriolar Microcirculation. PLOS ONE [ONLINE] 8: e65804. 2013

Mahendran Y, Ågren J, Uusitupa M, Cederberg H, Vangipurapu J, Stancakova A, Schwab U, Kuusisto J, Laakso M. 2013. Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes. AMERICAN JOURNAL OF CLINICAL NUTRITION -: -. 2013

Mahendran Yuvaraj, Cederberg Henna, Vangipurapu Jagadish, Kangas Antti J, Soininen Pasi, Kuusisto Johanna, Uusitupa Matti, Ala-Korpela Mika, Laakso Markku. 2013. Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men. DIABETES CARE 36: 3732-3738. 2013

Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, Chandel N, Laakso M, Muller WJ, Allen EL, Jha AK, Smolen GA, Clasquin MF, Robey RB, Hay N. 2013. Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. CANCER CELL 24: 213-228. 2013

Prudente S, Copetti M, Morini E, Mendonca C, Andreozzi F, Chandalia M, Baratta R; DIAGRAM consortium (including Kuusisto J, Laakso M), Pellegrini F, Mercuri L, Bailetti D, Abate N, Frittitta L, Sesti G, Florez JC, Doria A, Trischitta V. 2013. The SH2B1 obesity locus and abnormal glucose homeostasis: lack of evidence for association from a meta-analysis in individuals of European ancestry. NUTRITION, METABOLISM AND CARDIOVASCULAR DISEASES 23: 1043-1049. 2013

Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, Workalemahu T, Feitosa MF, Croteau-Chonka DC, Day FR, Fall T, Ferreira T, Gustafsson S, Locke AE, Mathieson I, Scherag A, et al. (including J Kuusisto, M Laakso, M Atalay, T Lakka). 2013. Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. PLOS GENETICS [ONLINE) 9 6: e1003500. 2013

Saxena R, Saleheen D, Been LF, Garavito ML, Braun T, Bjonnes A, Young R, Ho WK, Rasheed A, Frossard P, Sim X, Hassanali N, Radha V, Chidambaram M, Liju S, Rees SD, Ng DP, Wong TY, Yamauchi T, Hara K, et al. (including J Kuusisto, M Laakso). 2013. Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.. DIABETES (NY) 62 5: 1746-1755. 2013

Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, Ohman P, Frederich R, Wiviott SD, Hoffman EB, Cavender MA, Udell JA, Desai NR, Mosenzon O, McGuire DK, Ray KK, Leiter LA, Raz I; SAVOR-TIMI 53 Steering Committee and Investigators (including M Laakso). 2013. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus.. NEW ENGLAND JOURNAL OF MEDICINE 369: 1317-1326. 2013

Shimomura K, Tusa M, Iberl M, Brereton MF, Kaizik S, Proks P, Lahmann C, Yaluri N, Modi S, Huopio H, Ustinov J, Otonkoski T, Laakso M, Ashcroft FM. 2013. A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1. DIABETES (NY) 62: 3797-3806. 2013

Wu Y, Waite LL, Jackson AU, Sheu WH, Buyske S, Absher D, Arnett DK, Boerwinkle E, Bonnycastle LL, Carty CL, Cheng I, Cochran B, Croteau-Chonka DC, Dumitrescu L, Eaton CB, Franceschini N, Guo X, Henderson BE, Hindorff LA, Kim E, et al. (including Stancakova A, Kuusisto J, Laakso M, Uusitupa M, Rauramaa R Lakka T.). 2013. Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained. PLOS GENETICS [ONLINE) 9 3: e1003379. 2013

Simonen M, Männistö V, Leppänen J, Kaminska D, Kärjä V, Venesmaa S, Käkelä P, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. 2013. Desmosterol in human nonalcoholic steatohepatitis. HEPATOLOGY 58: 976-982. 2013

Singh GM, Danaei G, Farzadfar F, Stevens GA, Woodward M, Wormser D, Kaptoge S, Whitlock G, Qiao Q, Lewington S, Di Angelantonio E, Vander Hoorn S, Lawes CM, Ali MK, Mozaffarian D, Ezzati M, Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group, Asia-Pacific Cohort Studies Collaboration (APCSC), Diabetes Epidemiology: Collaborative analysis of Diagnostic criteria in Europ. 2013. The Age-Specific Quantitative Effects of Metabolic Risk Factors on Cardiovascular Diseases and Diabetes: A Pooled Analysis. PLOS ONE [ONLINE] 8 7: 1-10. 2013

Tabassum R, Chauhan G, Dwivedi OP, Mahajan A, Jaiswal A, Kaur I, Bandesh K, Singh T, Mathai BJ, Pandey Y, Chidambaram M, Sharma A, Chavali S, Sengupta S, Ramakrishnan L, Venkatesh P, Aggarwal SK, Ghosh S, Prabhakaran D, Srinath RK, et al (including M Laakso, J Kuusisto). 2013. Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21. DIABETES (NY) 62 3: 977-986. 2013

Takkunen M, Ågren J, Kuusisto J, Laakso M, Uusitupa M, Schwab U. 2013. Dietary fat in relation to erythrocyte fatty acid composition in men. LIPIDS 48: 1093-1102. 2013

Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, Wood AR, Michaëlsson K, Vandenput L, Zgaga L, Yerges-Armstrong LM, McCarthy MI, Dupuis J, Kaakinen M, Kleber ME, Jameson K, et al. (including Laakso M, Kuusisto J). 2013. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLOS MEDICINE 10 2: e1001383. 2013

Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang H-Y, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF et.al.. 2013. Discovery and refinement of loci associated with lipid levels. NATURE GENETICS 45 11: 1274-1283. 2013

Li H, Gan W, Lu L, Dong X, Han X, Hu C, Yang Z, Sun L, Bao W, Li P, He M, Sun L, Wang Y, Zhu J, Ning Q, Tang Y, Zhang R, Wen J, Wang D, Zhu X, et al. (including Kuusisto J, Laakso M). 2013. A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.. DIABETES (NY) 62 1: 291-298. 2013

Xie W, Wood AR, Lyssenko V, Weedon MN, Knowles JW, Alkayyali S, Assimes TL, Quertermous T, Abbasi F, Paananen J, Häring H, Hansen T, Pedersen O, Smith U, Laakso M; MAGIC Investigators; DIAGRAM Consortium; GENESIS Consortium; RISC Consortium, Dekker JM. 2013. Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes. DIABETES (NY) 62 6: 2141-2150. 2013

Yaghootkar H, Lamina C, Scott RA, Dastani Z, Hivert M-F, Warren LL, Stancáková A, Buxbaum SG, Lyytikäinen L-P, Henneman P, Wu Y, Cheung CYY, Pankow JS, Jackson AU, Gustafsson S, Zhao JH, Ballantyne CM, Xie W, Bergman RN, Boehnke M et al. (including J Kuusisto, M Laakso, J Paananen). 2013. Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.. DIABETES (NY) 62: 3589-3598. 2013

Lyssenko V, Laakso M. 2013. Genetic screening for the risk of type 2 diabetes. DIABETES CARE 36 Supplement 2: S120-S126. 2013

Mahendran Y, Vangipurapu J, Cederberg H, Stancáková A, Pihlajamäki J, Soininen P, Kangas AJ, Paananen J, Civelek M, Saleem NK, Pajukanta P, Lusis AJ, Bonnycastle LL, Morken MA, Collins FS, Mohlke KL, Boehnke M, Ala-Korpela M, Kuusisto J, Laakso M. 2013. Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men. DIABETES (NY) 62: 3618-3626. 2013

Laplante MA, Charbonneau A, Avramoglu RK, Pelletier P, Fang X, Bachelard H, Ylä-Herttuala S, Laakso M, Després JP, Deshaies Y, Sweeney G, Mathieu P, Marette A. 2013. Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models. AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM [PRINTED AND ONLINE: HTTP://AJPENDO.PHYSIOLOGY.ORG/] vol. 305 no. 5: E573-E584. 2013

Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang H-Y, Demirkan A, Den Hertog HM, Donnelly LA, Ehret GB, Esko T et.al.. 2013. Common variants associated with plasma triglycerides and risk for coronary artery disease. NATURE GENETICS 45 11: 1345-52. 2013

Ahlqvist E, Osmark P, Kuulasmaa T, Pilgaard K, Omar B, Brøns C, Kotova O, Zetterqvist AV, Stancáková A, Jonsson A, Hansson O, Kuusisto J, Kieffer TJ, Tuomi T, Isomaa B, Madsbad S, Gomez MF, Poulsen P, Laakso M, Degerman E, et al. (including Pihlajamäki J). 2013. Link between GIP and osteopontin in adipose tissue and insulin resistance. DIABETES (NY) 62 6: 2088-2094. 2013

Ahmad S, Rukh G, Varga TV, Ali A, Kurbasic A, Shungin D, Ericson U, Koivula RW, Chu AY, Rose LM, Ganna A, Qi Q, Stančáková A, Sandholt CH, Elks CE, Curhan G, Jensen MK, Tamimi RM, Allin KH, Jørgensen T et al. (including Laakso M). 2013. Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry. PLOS GENETICS [ONLINE) 9 7: e1003607. 2013

Laakso M. 2013. Tunnistatko diabetestyypin?. YLEISLÄÄKÄRI 28: 9-12. 2013

Avramoglu RK, Laplante M-A, Quang KL, Deshaies Y, Despres J-P, Larose E, Mathieu P, Poirier P, Perusse L, Vohl M-C, Sweeney G, Ylä-Herttuala S, Laakso M, Uusitupa M, Marette A. 2013. The Genetic and Metabolic Determinants of Cardiovascular Complications in Type 2 Diabetes: Recent Insights from Animal Models and Clinical Investigations. Canadian Journal of Diabetes 37 5: 351-358. 2013

Baldi S, Bonnet F, Laville M, Morgantini C, Monti L, Hojlund K, Ferrannini E, Natali A; RISC Investigators (including Laakso, M).. 2013. Influence of apolipoproteins on the association between lipids and insulin sensitivity: a cross-sectional analysis of the RISC Study.. DIABETES CARE 36 12: 4125-4131. 2013

Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, Luan J, Randall JC, Vedantam S, Willer CJ, Winkler TW, et al. (including Atalay M, Kuusisto J, Lakka TA, Stancakova A, Laakso M, Uusitupa M). 2013. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. NATURE GENETICS 45 5: 501-512. 2013

Bonnycastle LL, Chines PS, Hara T, Huyghe JR, Swift AJ, Heikinheimo P, Mahadevan J, Peltonen S, Huopio H, Nuutila P, Narisu N, Goldfeder RL, Stitzel ML, Lu S, Boehnke M, Urano F, Collins FS, Laakso M. 2013. Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation. DIABETES (NY) 62: 3943-3950. 2013

Cederberg H, Gylling H, Miettinen TA, Paananen J, Vangipurapu J, Pihlajamäki J, Kuulasmaa T, Stancáková A, Smith U, Kuusisto J, Laakso M. 2013. Non-cholesterol sterol levels predict hyperglycemia and conversion to type 2 diabetes in finnish men. PLOS ONE [ONLINE] 8 6: e67406. 2013

Civelek M, Hagopian R, Pan C, Che N, Yang WP, Kayne PS, Saleem NK, Cederberg H, Kuusisto J, Gargalovic PS, Kirchgessner TG, Laakso M, Lusis AJ.. 2013. Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits. HUMAN MOLECULAR GENETICS 22 15: 3023-3037. 2013

Albrechtsen A, Grarup N, Li Y, Sparsø T, Tian G, Cao H, Jiang T, Kim SY, Korneliussen T, Li Q, Nie C, Wu R, Skotte L, Morris AP, Ladenvall C, Cauchi S, Stančáková A, Andersen G, Astrup A, Banasik K, et al. (including Stancakova A, Kuusisto J, Laakso M). 2013. Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. DIABETOLOGIA 56: 298-310. 2013

Evans DM, Brion MJ, Paternoster L, Kemp JP, McMahon G, Munafò M, Whitfield JB, Medland SE, Montgomery GW; GIANT Consortium; CRP Consortium; TAG Consortium, Timpson NJ, St Pourcain B, Lawlor DA, Martin NG, Dehghan A, Hirschhorn J, Davey Smith G et al. (including M Laakso ja J Kuusisto). 2013. Mining the human phenome using allelic scores that index biological intermediates. PLOS GENETICS [ONLINE) 9: e1003919. 2013

Ezzat S, Zheng L, Florez JC, Stefan N, Mayr T, Hliang MM, Jablonski K, Harden M, Stančáková A, Laakso M, Haring HU, Ullrich A, Asa SL. 2013. The Cancer-Associated FGFR4-G388R Polymorphism Enhances Pancreatic Insulin Secretion and Modifies the Risk of Diabetes. Cell Metabolism 17 6: 929-940. 2013

Hammarstedt A, Hedjazifar S, Jenndahl L, Gogg S, Grünberg J, Gustafson B, Klimcakova E, Stich V, Langin D, Laakso M, Smith U.. 2013. WISP2 regulates preadipocyte commitment and PPARγ activation by BMP4. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110 7: 2563-2568. 2013

Hu Y-J, Berndt SI, Gustafsson S, Ganna A, Genetic Investigation of ANthropometric Traits (GIANT) Consortium (including M Atalay, T Lakka, J Kuusisto, M Laakso), Hirschhorn J, North KE, Ingelsson E, Lin D-Y et.al.. 2013. Meta-analysis of gene-level associations for rare variants based on single-variant statistics. AMERICAN JOURNAL OF HUMAN GENETICS 93 2: 236-248. 2013

Huopio H, Cederberg H, Vangipurapu J, Hakkarainen H, Pääkkönen M, Kuulasmaa T, Heinonen S, Laakso M. 2013. Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes. EUROPEAN JOURNAL OF ENDOCRINOLOGY 169 3: 291-297. 2013

Huyghe JR, Jackson AU, Fogarty MP, Buchkovich ML, Stancáková A, Stringham HM, Sim X, Yang L, Fuchsberger C, Cederberg H, Chines PS, Teslovich TM, Romm JM, Ling H, McMullen I, Ingersoll R, Pugh EW, Doheny KF, Neale BM, Daly MJ, et al (including J Kuusisto, M Laakso). 2013. Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion. NATURE GENETICS 45 2: 197-201. 2013

Jääskeläinen P, Heliö T, Aalto-Setälä K, Kaartinen M, Ilveskoski E, Hämäläinen L, Melin J, Nieminen MS, Laakso M, Kuusisto J; FinHCM study group, Kervinen H, Mustonen J, Juvonen J, Niemi M, Uusimaa P, Huttunen M, Kotila M, Pietilä M.. 2013. Two founder mutations in the alpha-tropomyosin and the cardiac myosin-binding protein C genes are common causes of hypertrophic cardiomyopathy in the Finnish population. Annals of Medicine 45: 85-90. 2013

Kaminska D, Hämäläinen M, Cederberg H, Käkelä P, Venesmaa S, Miettinen P, Ilves I, Herzig KH, Kolehmainen M, Karhunen L, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. 2013. Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss. DIABETOLOGIA Epub 2013 Nov 7.: 1-5. 2013

Kozakova M, Natali A, Dekker J, Beck-Nielsen H, Laakso M, Nilsson P, Balkau B, Ferrannini E; RISC Investigators. 2013. Insulin sensitivity and carotid intima-media thickness: relationship between insulin sensitivity and cardiovascular risk study. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 33 6: 1409-1417. 2013

Kuusisto J, Laakso M. 2013. Update on type 2 diabetes as a cardiovascular disease risk equivalent. CURRENT CARDIOLOGY REPORTS 15: 331. 2013

Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik L, Yengo L, Lecoeur C, Shungin D, Sanna S, Sidore C, Johnson PCD, Jukema JW, Johnson T et.al.. 2012. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. NATURE GENETICS 44 9: 991-1005. 2012

Scott RA, Chu AY, Grarup N, ManningAK, Hivert M-F, Shungin D, Tönjes A, Yesupriya A, Barnes D, Bouatia-Naji N, Glazer NL, Jackson AU, Kutalik Z, Lagou V, Marek D, Rasmussen-Torvik LJ, Stringham HM, Tanaka T, Aadah M, Arking DE et.al.. 2012. No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels DIABETES (NY) 61 5: 1291-1296. 2012

Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN, Bostrom MA, Rudock ME, Talbert ME, Lewis JP; DIAGRAM Consortium; MAGIC Investigators, Ferrara A, Lu L, Ziegler JT, Sale MM, Divers J, Shriner D et.al.. 2012. A genome-wide association search for type 2 diabetes genes in African Americans. PLOS ONE [ONLINE] 7 1: e29202. 2012

Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN, Gao P, Saleheen D, Rendon A, Nelson CP, Braund PS, Hall AS, Chasman DI, Tybjaerg-Hansen A, Chambers JC, Benjamin EJ, Franks PW, Clarke R, Wilde AAM, Trip MD et.al.. 2012. Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. LANCET 379 9822: 1205-1213. 2012

Pihlajamäki J, Lerin C, Kaminska D, Venesmaa S, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W et.al.. 2012. Response to Brosch et al.. Cell Metabolism 15 3: 267-269. 2012

Pihlajamäki J, Kuulasmaa T, Kaminska D, Simonen M, Kärjä V, Grönlund S, Käkelä P, Pääkkönen M, Kainulainen S, Punnonen K, Kuusisto J, Gylling H, Laakso M. 2012. Serum interleukin 1 receptor antagonist as anindependent marker of non-alcoholic steatohepatitis in humans. JOURNAL OF HEPATOLOGY 56 3: 663-670. 2012

Smeele KM, Eerbeek O, Schaart G, Koeman A, Bezemer R, Nelson JK, Ince C, Nederlof R, Boek M, Laakso M, de Haan A, Drost MR, Hollmann MW, Zuurbier CJ. 2012. Reduced hexokinase II impairs muscle function 2 wk after ischemia-reperfusion through increased cell necrosis and fibrosis. JOURNAL OF APPLIED PHYSIOLOGY 113: 608-618. 2012

Simonen M, Dali-Youcef N, Kaminska D, Venesmaa S, Käkelä P, Pääkkönen M, Hallikainen M, Kolehmainen M, Uusitupa M, Moilanen L, Laakso M, Gylling H, Patti ME, Auwerx J, Pihlajamäki J. 2012. Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass. OBESITY SURGERY 22 9: 1473-1480. 2012

Vepsäläinen T, Laakso M, Kantola I, Lehto S, Juutilainen A, Rönnemaa T. 2012. Proteinuria modifies the effect of systolic blood pressure on total and cardiovascular disease mortality in patients with type 2 diabetes.. JOURNAL OF INTERNAL MEDICINE 272 6: 611-619. 2012

Stahl EA, Wegmann D, Trynka G, Gutierrez-Achury J, Do R, Voight BF, Kraft P, Chen R, Kallberg HJ, Kurreeman FA; Diabetes Genetics Replication and Meta-analysis Consortium; Myocardial Infarction Genetics Consortium, Kathiresan S, Wijmenga C, Gregersen PK, Alfredsson L, Siminovitch KA, Worthington J, de Bakker PI, Raychaudhuri S, Plenge RM. 2012. Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. NATURE GENETICS 44: 483-489. 2012

Stancáková Alena, Civelek Mete, Saleem Niyas K, Soininen Pasi, Kangas Antti J, Cederberg Henna, Paananen Jussi, Pihlajamäki Jussi, Bonnycastle Lori L, Morken Mario A, Boehnke Michael, Pajukanta Päivi, Lusis Aldons J, Collins Francis S, Kuusisto Johanna, Ala-Korpela Mika, Laakso Markku. 2012. Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men. DIABETES (NY) 61: 1895-1902. 2012

The CARDIoGRAMplusC4D Consortium (including M Laakso, J Kuusisto), Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, Stirrups K, König IR, Cazier JB, Johansson A, Hall AS, Lee JY, Willer CJ, Chambers JC, Esko T et al. 2012. Large-scale association analysis identifies new risk loci for coronary artery disease. NATURE GENETICS 45 1: 25-33. 2012

Ting RD, Keech AC, Drury PL, Donoghoe MW, Hedley J, Jenkins AJ, Davis TM, Lehto S, Celermajer D, Simes RJ, Rajamani K, Stanton K; FIELD Study Investigators. 2012. Benefits and safety of long-term fenofibrate therapy in people with type 2 diabetes and renal impairment: the FIELD Study. DIABETES CARE 35: 218-225. 2012

Vangipurapu Jagadish, Stančáková A, Kuulasmaa Teemu, Soininen Pasi, Kangas AJ, Ala-Korpela Mika, Kuusisto Johanna, Laakso Markku. 2012. Association between liver insulin resistance and cardiovascular risk factors JOURNAL OF INTERNAL MEDICINE 272: 402-408. 2012

Wang J, Stančáková A, Soininen P, Kangas AJ, Paananen J, Kuusisto J, Ala-Korpela M, Laakso M. 2012. Lipoprotein subclass profiles in individuals with varying degrees of glucose tolerance: a population-based study of 9399 Finnish men. JOURNAL OF INTERNAL MEDICINE 272: 562-572. 2012

Wu R, Wyatt E, Chawla K, Tran M, Ghanefar M, Laakso M, Epting CL, Ardehali H. 2012. Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production. EMBO molecular medicine (Print) 4: 633-646. 2012

Würtz Peter, Tiainen Mika, Mäkinen Ville-Petteri, Kangas Antti, Soininen Pasi, Saltevo Juha, Keinänen-Kiukaanniemi Sirkka, Mäntyselkä Pekka, Lehtimäki Terho, Laakso Markku, Jula Antti, Kähönen Mika, Vanhala Mauno, Ala-Korpela Mika. 2012. Circulating Metabolite Predictors of Glycemia in Middle-Aged Men and Women. DIABETES CARE 35: 1749-1756. 2012

Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, Prokopenko I, Kang HM, Dina C, Esko T, Fraser RM, Kanoni S, Kumar A, Lagou V, Langenberg C, Luan J et.al.. 2012. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. NATURE GENETICS 44 9: 981-990. 2012

Nerstedt A, Cansby E, Andersson CX, Laakso M, Stancakova A, Blüher M, Smith U, Mahlapuu M. 2012. Serine/threonine protein kinase 25(STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal muscle. DIABETOLOGIA 55 6: 1797-1807. 2012

Ahola AJ, Harjutsalo V, Saraheimo M, Forsblom C, Groop PH; FinnDiane Study Group.. 2012. Purchase of antidepressant agents by patients with type 1 diabetes is associated with increased mortality rates in women but not in men. DIABETOLOGIA 55 1: 73-79. 2012

Marquez M, Huyvaert M, Perry JR, Pearson RD, Falchi M, Morris AP, Vivequin S, Lobbens S, Yengo L, Gaget S, Pattou F, Poulain-Godefroy O, Charpentier G, Carlsson LM, Jacobson P, Sjöström L, Lantieri O, Heude B, Walley A, Balkau B, Marre M, Froguel P, Cauchi S; DIAGRAM Consortium. 2012. Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. DIABETES (NY) 61 2: 524-530. 2012

Heine RJ, Dekker J, Nijpels G, Boorsma W, Mitrakou A, Tournis S, Kyriakopoulou K, Thomakos P, Lalic N, Lalic K, Jotic A, Lukic L, Civcic M, Nolan J, Yeow TP, Murphy M, DeLong C, Neary G, Colgan MP, Hatunic M, et al. (inclunding Laakso). 2012. From metabolic normality to cardiometabolic risk factors in subjects with obesity.. OBESITY (SILVER SPRING, MD.) 20 10: 2063-2069. 2012

Manning AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, Rybin D, Liu CT, Bielak LF, Prokopenko I, Amin N, Barnes D, Cadby G, Hottenga JJ, Ingelsson E, Jackson AU, Johnson T, Kanoni S, Ladenvall C, Lagou V et.al.. 2012. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance NATURE GENETICS 44 6: 659-669. 2012

Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, Beekman M, Coassin S, Lohman K, Qi L, Kanoni S et.al.. 2012. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.. PLOS GENETICS [ONLINE) 8 3: e1002607. 2012

de Mello Laaksonen VD, Lindström J, Eriksson J, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Sundvall J, Laakso M, Tuomilehto J, Uusitupa M. 2012. Insulin secretion and its determinants in the progression of impaired glucose tolerance to type 2 diabetes in impaired glucose-tolerant individuals: the finnish diabetes prevention study DIABETES CARE 35: 211-217. 2012

Demirkan A, van Duijn CM, Ugocsai P, Isaacs A, Pramstaller PP, Liebisch G, Wilson JF, Johansson Å, Rudan I, Aulchenko YS, Kirichenko AV, Janssens AC, Jansen RC, Gnewuch C, Domingues FS, Pattaro C, Wild SH, Jonasson I, Polasek O, Zorkoltseva IV et.al.. 2012. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. PLOS GENETICS [ONLINE) 8 2: e1002490. 2012

Eriksson JG, Gelow J, Thornburg KL, Osmond C, Laakso M, Uusitupa M, Lindi V, Kajatie E, Barker DJP. 2012. Long-term effects of placental growth on overweight and body composition. International journal of pediatrics 2012 2012:324185 Epub 2012 Apr 18.: 6 pages. 2012

Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K; GIANT Consortium; MAGIC Consortium; GLGC Consortium, Johnson AD, Foster MC, Greenawalt DM, Griffin P, Ding J, Newman AB, Tylavsky F, Miljkovic I, Kritchevsky SB, Launer L et.al.. 2012. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women PLOS GENETICS [ONLINE) 8 5: e1002695. 2012

Handberg A, Højlund K, Gastaldelli A, Flyvbjerg A, Dekker JM, Petrie J, Piatti P, Beck-Nielsen H; RISC Investigators. 2012. Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population. JOURNAL OF INTERNAL MEDICINE 271 3: 294-304. 2012

Haas BE, Horvath S, Pietiläinen KH, Cantor RM, Nikkola E, Weissglas-Volkov D, Rissanen A, Civelek M, Cruz-Bautista I, Riba L, Kuusisto J, Kaprio J, Tusie-Luna T, Laakso , Aguilar-Salinas CA, Pajukanta P. 2012. Adipose Co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes. BMC Medical Genomics 5: 61. 2012

Hiltunen M, Khandelwal VKM, Yaluri N, Tiilikainen T, Tusa M, Koivisto H, Krzisch M, Vepsäläinen S, Mäkinen P, Kemppainen S, Miettinen P, Haapasalo A, Soininen H, Laakso M, Tanila H. 2012. Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 16: 1206-1222. 2012

Kozakova M, Palombo C, Eng MP, Dekker J, Flyvbjerg A, Mitrakou A, Gastaldelli A, Ferrannini E; RISC Investigators.. 2012. Fatty liver index, gamma-glutamyltransferase, and early carotid plaques. HEPATOLOGY 55 5: 1406-1415. 2012

Laakso M, Cederberg H. 2012. Glucose control in diabetes: which target level to aim for?. JOURNAL OF INTERNAL MEDICINE 272: 1-12. 2012

Imamura M, Maeda S, Yamauchi T, Hara K, Yasuda K, Morizono T, Takahashi A, Horikoshi M, Nakamura M, Fujita H, Tsunoda T, Kubo M, Watada H, Maegawa H, Okada-Iwabu M, Iwabu M, Shojima N, Ohshige T, Omori S, Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium (including M Laakso, J Kuusisto). 2012. A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.. HUMAN MOLECULAR GENETICS 21: 3042-3049. 2012

Kristiansson Kati, Perola Markus, Tikkanen Emmi, Kettunen Johannes, Surakka Ida, Havulinna Aki S, Stancáková Alena, Barnes Chris, Widen Elisabeth, Kajantie Eero, Eriksson Johan G, Viikari Jorma, Kähönen Mika, Lehtimäki Terho, Raitakari Olli T, Hartikainen Anna-Liisa, Ruokonen Aimo, Pouta Anneli, Jula Antti, Kangas Antti J et al. 2012. Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. Circulation: Cardiovascular Genetics 5: 242-249. 2012

Kuusisto J, Kärjä V, Sipola P, Kholová I, Peuhkurinen K, Jääskeläinen P, Naukkarinen A, Ylä-Herttuala S, Punnonen K, Laakso M. 2012. Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy. HEART 98 13: 1007-1013. 2012

Koponen T, Cerrada-Gimenez M, Pirinen E, Hohtola E, Paananen J, Vuohelainen S, Tusa M, Pirnes-Karhu S, Heikkinen S, Virkamäki A, Uimari A, Alhonen L, Laakso M.. 2012. The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis. AMINO ACIDS 42: 427-440. 2012

Kelly MA, Rees SD, Hydrie MZI, Shera AS, Bellary S, O¿Hare JP, Kumar S, Taheri S, Basit A, Barnett AH, DIAGRAM consortium, SAT2D consortium. 2012. Circadian gene variants and susceptibility to type 2 diabetes: a pilot study. PLOS ONE [ONLINE] 7 4: e32670. 2012

Kaminska D, Kuulasmaa T, Venesmaa S, Käkelä P, Vaittinen M, Pulkkinen L, Pääkkönen M, Gylling H, Laakso M, Pihlajamäki J. 2012. Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism. DIABETES (NY) 61: 2807-2813. 2012

Smeele KM, Southworth R, Wu R, Xie C, Nederlof R, Warley A, Nelson JK, van Horssen P, van den Wijngaard JP, Heikkinen S, Laakso M, Koeman A, Siebes M, Eerbeek O, Akar FG, Ardehali H, Hollmann MW, Zuurbier CJ. 2011. Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis CIRCULATION RESEARCH 108: 1165-1169. 2011

Laakso M. 2011. Onko diabeteksen geenidiagnostiikasta hyötyä potilastyössä?. SUOMEN LÄÄKÄRILEHTI 66 1-2: 37-42. 2011

Lidell ME, Seifert EL, Westergren R, Heglind M, Gowing A, Sukonina V, Arani Z, Itkonen P, Wallin S, Westberg F, et al.. 2011. The Adipocyte-expressed forkhead transcription factor foxc2 regulates metabolism through altered mitochondrial function. DIABETES (NY) 60: 427-435. 2011

Lyssenko V, Eliasson L, Kotova O, Pilgaard K, Wierup N, Salehi A, Wendt A, Jonsson A, De Marinis YZ, Berglund LM, Taneera J, Balhuizen A, Hansson O, Osmark P, Dunér P, Brøns C, Stancáková A, Kuusisto J, Bugliani M, Saxena R, et al.. 2011. Pleiotropic Effects of GIP on Islet Function Involves Osteopontin DIABETES (NY) 60: 2424-2433. 2011

Mari A, Tura A, Natali A, Anderwald C, Balkau B, Lalic N, Walker M, Ferrannini E, for the RISC Investigators (including Laakso M). 2011. Influence of hyperinsulinemia and insulin resistance on in vivo β-cell function: their role in human β-cell dysfunction. DIABETES (NY) 60: 3141-3147. 2011

Pihlajamäki J, Kuulasmaa T, Kaminska D, Simonen M, Kärjä V, Grönlund S, Käkelä P, Pääkkönen M, Kainulainen S, Punnonen K, Kuusisto J, Gylling H, Laakso M. 2011. Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans JOURNAL OF HEPATOLOGY 56 3: 663-670. 2011

Pihlajamäki Jussi, Lerin Carles, Itkonen Paula, Boes Tanner, Thomas Floss Thomas, Schroeder Joshua, Dearie Farrell, Crunkhorn Sarah, Burak Furkan, Jimenez-Chillaron Josep C., Kuulasmaa Tiina, Miettinen Pekka, Park Peter J., Nasser Imad, Zhao Zhenwen, Zhang Zhaiyi, Xu Yan, Wurst Wolfgang, Ren Hongmei, Morris Andrew J.Stamm Stefan, Goldfine Allison B., Laakso Markku, Patti Mary Elizabeth. 2011. Expression of the Splicing Factor Gene SFRS10 Is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis Cell Metabolism 14 2: 208-218. 2011

Sanna S, Li B, Mulas A, Sidore C, Kang HM, Jackson AU, Grazia Piras M, Usala G, Maninchedda G, Sassu A, Serra F, Palmas MA, Wood III WH, Njølstad I, Laakso M, Hveem K, Tuomilehto J, Lakka TA, Rauramaa R, Boehnke M,et al.. 2011. Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability PLOS GENETICS [ONLINE) 7: e1002198. 2011

Zhu H, Shyh-Chang N, Segrè AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, Urbach A, Thornton JE, Triboulet R, Gregory RI; DIAGRAM Consortium; MAGIC Investigators, Altshuler D, Daley GQ. 2011. The Lin28/let-7 axis regulates glucose metabolism CELL 147 1: 81-94. 2011

Smeele KM, Ter Horst LH, Koeman A, Heikkinen S, Laakso M, Weber NC, Hollmann MW, Zuurbier CJ. 2011. The effect of standard chow and reduced hexokinase II on growth, cardiac and skeletal muscle hexokinase and low-flow cardiac ischaemia-reperfusion injury LABORATORY ANIMALS 45: 160-166. 2011

Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, Nalls MA, Clark JM, Mitchell BD, Shuldiner AR, Butler JL, Tomas M, Hoffmann U, Hwang SJ, Massaro JM, O'Donnell CJ, Sahani DV, Salomaa V, Schadt EE, Schwartz SM, Siscovick DS; NASH CRN; GIANT Consortium; MAGIC Investigators (including M. Laakso), Voight BF, Carr JJ, Feitosa MF, H. 2011. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits PLOS GENETICS [ONLINE) 7 3: e1001324. 2011

Stancáková A, Paananen J, Soininen P, Kangas AJ, Bonnycastle LL, Morken MA, Collins FS, Jackson AU, Boehnke ML, Kuusisto J, Ala-Korpela M, Laakso M. 2011. Effects of 34 Risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men DIABETES (NY) 60: 1608-1616. 2011

Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME, Bouatia-Naji N, Dimas AS, Nica A, Wheeler E, Chen H, Voight BF, Taneera J, Kanoni S, Peden JF, Turrini F, Gustafsson S, Zabena C, et al. 2011. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes DIABETES (NY) 60: 2624-2534. 2011

Uusitupa MI, Stancáková A, Peltonen M, Eriksson JG, Lindström J, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M. 2011. Impact of positive family history and genetic risk variants on the incidence of diabetes - the Finnish Diabetes Prevention Study. DIABETES CARE Online January 2011: 1-6. 2011

Vangipurapu J, Stancakova A, Kuulasmaa T, Paananen J, Kuusisto J, EGIR-RISC Study Group, Ferrannini E, Laakso M. 2011. A novel surrogate index for hepatic insulin resistance DIABETOLOGIA 54: 540-543. 2011

Vangipurapu J, Stancakova A, Pihlajamäki J, Kuulasmaa TM, Kuulasmaa T, Paananen J, Kuusisto J, Ferrannini E, Laakso M. 2011. Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men DIABETOLOGIA 54: 563-571. 2011

Vepsäläinen T, Soinio M, Marniemi J, Lehto S, Juutilainen A, Laakso M, Rönnemaa T. 2011. Physical activity, high-sensitivity C-reactive protein, and total and cardiovascular disease mortality in type 2 diabetes DIABETES CARE 34: 1492-1496. 2011

Wessman M, Forsblom C, Kaunisto M, Söderlund J, Ilonen J, Sallinen R, Hiekkalinna T, Parkkonen M, Maxwell A, Tarnow L et.al.. 2011. Novel Susceptibility Locus at 22q11 for Diabetic Nephropathy in Type 1 Diabetes PLOS ONE [ONLINE] 6: 1-9. 2011

Laakso M. 2011. Heart in diabetes: a microvascular disease DIABETES CARE 34 Suppl 2: S145-S149. 2011

Koeck T, Olsson AH, Nitert MD, Sharoyko VV, Ladenvall C, Kotova O, Reiling E, Rönn T, Parikh H, Taneera J, Eriksson JG, Metodiev MD, Larsson NG, Balhuizen A, Luthman H, Stančáková A, Kuusisto J, Laakso M, Poulsen P, Vaag A. 2011. A Common Variant in TFB1M Is Associated with Reduced Insulin Secretion and Increased Future Risk of Type 2 Diabetes Cell Metabolism 13: 80-91. 2011

Kilpeläinen Tuomas O, Qi Lu, Brage Soren, Sharp Stephen J., Sonestedt Emily, Demerath Ellen, Ahmad Tariq, Mora Samia, Kaakinen Marika, Sandholt Camilla H, Holzapfel Christina, Autenrieth Christine S., Hyppönen Elina, Cauchi Stéphane , He Meian, Kutalik Zoltan, Kumari Meena, Stancaková Alena, Meidtner Karina, Balkau Beverley et al.. 2011. Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children PLOS MEDICINE 8 11: e1001116. 2011

Fox ER, Young JH, Li Y, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC, Ganesh S, Kutlar A, Ramachandran VS, Polak JF, Fabsitz RR, Dries DL, Farlow DN, Redline S, Adeyemo A, Hirschorn JN, Sun YV, Wyatt SB, Penman AD, Palmas W, Rotter JI, Townsend RR, Doumatey AP, Tayo BO, Mosley TH Jr, Lyon HN, Kang SJ, Rotimi CN, Cooper RS, Franceschini N, Curb JD, Martin LW, Eaton CB, Kardia SL, Taylor . 2011. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. HUMAN MOLECULAR GENETICS 20: 2273-2284. 2011

Kilpeläinen TO, Zillikens MC, Stančáková A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L, Styrkarsdottir U, Zhou Y, Smith AV, Zhao JH, Amin N, Vedantam S, Shin SY, Haritunians T, Fu M, Feitosa MF, Kumari M et al.. 2011. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile NATURE GENETICS 43: 753-760. 2011

Cederberg H, Mikkola I, Jokelainen J, Laakso M, Härkönen P, Ikäheimo T, Laakso M, Keinänen-Kiukaanniemi S. 2011. Exercise during military training improves cardiovascular risk factors in young men ATHEROSCLEROSIS 216: 489-495. 2011

Cederberg H, Rajala U, Koivisto VM, Jokelainen J, Surcel HM, Keinänen-Kiukaanniemi S, Laakso M. 2011. Unacylated ghrelin is associated with changes in body composition and body fat distribution during a long-term exercise intervention EUROPEAN JOURNAL OF ENDOCRINOLOGY 165: 243-248. 2011

Chambers John C, Zhang Weihua, Sehmi Joban, Li Xinzhong, Wass Mark N, Van der Harst Pim, Holm Hilma, Sanna Serena, Kavousi Maryam, Baumeister Sebastian E, Coin Lachlan J, Deng Guohong, Gieger Christian, Heard-Costa Nancy L, Hottenga Jouke-Jan, Kühnel Brigitte, Kumar Vinod, Lagou Vasiliki, Liang Liming, Luan Jian'an et.al.. 2011. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma NATURE GENETICS 43 11: 1131-1138. 2011

Cho YS, Chen CH, Hu C, Long J, Ong RT, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang YC, Kwak SH, Ma RC, Yamamoto K, Adair LS, Aung T, Cai Q, Chang LC, Chen YT,... Kuusisto J, Laakso M. 2011. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.. NATURE GENETICS 44 1: 67-72. 2011

Ferrannini E, Betteridge DJ, Dormandy JA, Charbonnel B, Wilcox RG, Spanheimer R, Erdmann E, DeFronzo RA, Laakso M. 2011. High-density lipoprotein-cholesterol and not HbA1c was directly related to cardiovascular outcome in PROactive DIABETES, OBESITY AND METABOLISM 13: 759-764. 2011

Ferrannini E, Natali A, Muscelli E, Nilsson PM, Golay A, Laakso M, Beck-Nielsen H, Mari A; on behalf of the RISC Investigators. 2011. Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study DIABETOLOGIA 54: 1507-1516. 2011

Andersson EA, Harder MN, Pilgaard K, Pisinger C, Stančáková A, Kuusisto J, Grarup N, Færch K, Poulsen P, Witte DR, Jørgensen T, Vaag A, Laakso M, Pedersen O, Hansen T. 2011. The Birth Weight Lowering C-Allele of rs900400 Near LEKR1 and CCNL1 Associates with Elevated Insulin Release following an Oral Glucose Challenge PLOS ONE [ONLINE] 6: e27096. 2011

Haas BE, Weissglas-Volkov D, Aguilar-Salinas CA, Nikkola E, Vergnes L, Cruz-Bautista I, Riba L, Stancakova A, Kuusisto J, Soininen P, Kangas AJ, Ala-Korpela M, Tusie-Luna T, Laakso M, Pajukanta P. 2011. Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 31: 1201-1207. 2011

Hallikainen Maarit, Kurl Sudhir, Laakso Markku, Miettinen Tatu A, Gylling Helena. 2011. Plant stanol esters lower LDL cholesterol level in statin-treated subjects with type 1 diabetes by interfering the absorption and synthesis of cholesterol. ATHEROSCLEROSIS 217: 473-478. 2011

Heinonen Suvi E, Merentie Mari, Hedman Marja, Mäkinen Petri I, Loponen Elina, Kholová Ivana, Bosch Fatima, Laakso Markku, Ylä-Herttuala Seppo. 2011. Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice. CARDIOVASCULAR DIABETOLOGY [ONLINE: HTTP://WWW.CARDIAB.COM/] 10: 1-12. 2011

Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stančáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, Farese RV Jr, Kahn CR, et al.. 2011. SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome MOLECULAR CELL 44: 177-190. 2011

Hribal ML, Presta I, Procopio T, Marini MA, Stančáková A, Kuusisto J, Andreozzi F, Hammarstedt A, Jansson PA, Grarup N, Hansen T, Walker M, Stefan N, Fritsche A, Häring HU, Pedersen O, Smith U, Laakso M, Sesti G; on behalf of the EUGENE2 Consortium. 2011. Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B DIABETOLOGIA 54: 795-802. 2011

International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O'Reilly PF, Amin N, Bragg-Gresham JL, Teumer A, Glazer NL, Launer L, Zhao JH et. al.. 2011. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk NATURE (LONDON) 478 7367: 103-109. 2011

Jafar-Mohammadi B, Groves CJ, Gjesing AP, Herrera BM, Winckler W, Stringham HM, Morris AP, Lauritzen T, Doney ASF, Morris AD, Weedon MN, Swift AJ, Kuusisto J, Laakso M, Altshuler D, Hattersley AT, Collins FS, Boehnke M, Hansen T, Pedersen O, Palmer CNA, Frayling TM, DIAGRAM Consortium, Gloyn AL, McCarthy MI. 2011. A role for coding functional variants in HNF4A in type 2 diabetes susceptibility. DIABETOLOGIA 54: 111-119. 2011

Johnson T, Gaunt TR, Newhouse SJ, Padmanabhan S, Tomaszewski M, Kumari M, Morris RW, Tzoulaki I, O'Brien ET, Poulter NR, Sever P, Shields DC, Thom S, Wannamethee SG, Whincup PH, Brown MJ, Connell JM, Dobson RJ, Howard PJ,...BPgen Consortium (including M Laakso). 2011. Blood pressure loci identified with a gene-centric array AMERICAN JOURNAL OF HUMAN GENETICS 89: 688-700. 2011

Kaunisto K, Ojaniemi M, Juuti A-K, Huopio H, Laakso M, Veijola R. 2011. Äidin ja vastasyntyneen diabetes - pistoksista pillereihin DUODECIM 127: 61-64. 2011

Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, Bouatia-Naji N, Dupuis J, Jackson AU, Kao WH, Li M, Glazer NL, Manning AK, Luan J, Stringham HM, Prokopenko I, Johnson T, Grarup N, Boesgaard TW et al.. 2010. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge NATURE GENETICS 42: 142-148. 2010

Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, Bouatia-Naji N, .., Kuusisto J, Laakso M, et al.. 2010. Genetic variation in gastric inhibitory polypeptide receptor (GIPR): Impacts the glucose and insulin responses to an oral glucose challenge. NATURE GENETICS 42: 142-148. 2010

Perry JR, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T, Thorleifsson G, ..., Kuusisto J, ..., Laakso M, et al. 2010. Genetic evidence that raised Sex Hormone Binding Globulin (SHBG) levels reduce the risk of type 2 diabetes. HUMAN MOLECULAR GENETICS 19: 535-544. 2010

Rutanen J, Yaluri N, Modi S, Pihlajamäki J, Vänttinen M, Itkonen P, Kainulainen S, Yamamoto H, Lagouge M, ..., Laakso M. 2010. SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity. DIABETES (NY) 59: 829-835. 2010

Ruotsalainen E, Stancakova A, Vauhkonen I, Salmenniemi U, Pihlajamäki J, Punnonen K, Laakso M. 2010. Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects ATHEROSCLEROSIS 210: 536-541. 2010

Pirinen E, Gylling H, Itkonen P, Yaluri N, Heikkinen S, Pietilä M, Kuulasmaa T, Tusa M, Cerrada-Gimenez M, Pihlajamäki J, Alhonen L, Jänne J, Miettinen TA & Laakso M. 2010. Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis. AMINO ACIDS 38: 549-560. 2010

Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, Dupuis J, Bouatia-Naji N, Langenberg C, Prokopenko I, Stolerman E, Sandhu MS, Heeney MM, Devaney JM, Reilly MP, Ricketts SL, Stewart AF, Voight BF, Willenborg C, Wright B, Altshuler D, et al. on behalf of Procardis Consortium. 2010. Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways DIABETES (NY) 59: 3229-3239. 2010

Smeele KM, Eerbeek O, Koeman A, Bezemer R, Ince C, Heikkinen S, Laakso M, de Haan A, Schaart G, Drost MR, et al. 2010. Partial hexokinase II knocout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY 459: 705-712. 2010

Wang J, Sarnola K, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M & Kuusisto J. 2010. The metabolic syndrome predicts incident congestive heart failure: a 20-year follow-up study of elderly Finns. ATHEROSCLEROSIS 210: 237-242. 2010

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren CM, ..., Kuusisto J, ..., Laakso M, et al.. 2010. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.. NATURE GENETICS 42: 937-948. 2010

Tabara Y, Kohara K, Kita Y, Hirawa N, Katsuya T, Ohkubo T, Hiura Y, Tajima A, Morisaki T, Miyata T, et al.. 2010. Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millenium Genome Project HYPERTENSION 56 5: 973-980. 2010

Vepsäläinen T, Soinio M, Lehto S, Juutilainen A, Laakso M, Rönnemaa T. 2010. Proteinuria modifies the effects of physical activity on total and cardiovascular disease mortality rates in patients with type 2 diabetes. DIABETOLOGIA 53: 1886-1889. 2010

Voight BF,Scott LJ,Steinthorsdottir V,Morris AP,Dina C,Welch RP,Zeggini E,Huth C,..., ,Kuusisto J,..., Laakso M,et al.. 2010. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. NATURE GENETICS 42: 579-589. 2010

Wang J, Stancakova A, Kuusisto J, Laakso M. 2010. Identification of undiagnosed type 2 diabetic individuals by the Finnish diabetes risk score, biochemical and genetic markers: A population-based study of 7232 Finnish men. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 95: 3858-3862. 2010

Weyrich P, Staiger H, Stancakova A, Machicao F, Machann J, Schick F, Stefan N, Kuusisto J, Laakso M, Schäfer S, Fritsche A, Häring H-U. 2010. The D299G/T3991 toll-like receptor 4 variant associates with body and liver fat: results from the TULIP and METSIM studies. PLOS ONE [ONLINE] 5 11: e13980. 2010

Wu R, Smeele KM, Wyatt E, Ichikawa Y, Eerbeek O, Sun L, Chawla K, MS, Hollmann MW, Nagpal V, Heikkinen S, Laakso M, Jujo K, Wasserstrom JA, Zuurbier CJ, Ardehali H. 2010. Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia-reperfusion injury. CIRCULATION RESEARCH 108: 60-69. 2010

Natali A, Muscelli E, Mari A, Balkau B, Walker M, Tura A, Anderwald C, Golay A, & Ferrannini E, the Relationship between Insulin Sensitivity and Cardiovascular disease investigators. 2010. Insulin sensitivity and beta-cell function in the offspring of type 2 diabetic patients: impact of line of inheritance. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 95 10: 4703-4711. 2010

Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN, Hivert MF, Ngwa J, van Rooij FJ, Sonestedt E, Wojczynski MK, Ye Z, Tanaka T, Garcia M, Anderson JS, Follis JL, Djousse L, Mukamal K, Papoutsakis C, Mozaffarian D, Zillikens MC, Bandinelli S (including M Laakso). 2010. Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.. DIABETES CARE 33 12: 2684-2691. 2010

McMurray JJ, Holman RR, Haffner SM, Bethel MA, Holzhauer B, Hua TA, Belenkov Y, Boolell M, Buse JB, Buckley BM, Chacra AR, Chiang F-T, Charbonnel B, Chow C-C, Davies MJ, Deedwania P, Diem P, Einhorn D, Fonseca V, Fulcher GR, et al. for The NAVIGAT. 2010. Effect of valsartan on the incidence of diabetes and cardiovascular events NEW ENGLAND JOURNAL OF MEDICINE 362: 1477-1490. 2010

Ahola AJ, Thorn LM, Saraheimo M, Forsblom C, Groop P-H, & on behalf of the Finndiane Study Group. 2010. Depression is associated with the metabolic syndrome among patients with type 1 diabetes. Annals of Medicine 42: 495-501. 2010

Ikram MK, Xueling S, Jensen RA, Cotch MF, Hewitt AW, Ikram MA, Wang JJ, Klein R, Klein BE, Breteler MMB, et al.. 2010. Four Novel loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. PLOS ONE [ONLINE] 6 10: e1001184. 2010

Mari A, Tura A, Natali A, Laville M, Laakso M, Gabriel R, Beck-Nielsen H, Ferrannini E, RISC Investigators. 2010. Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance DIABETOLOGIA 53: 749-756. 2010

Anderwald C, Stadler M, Golay A, Krebs M, Petrie J, Luger A on behalf of the RISC Investigators. 2010. Impact of family history on relations between insulin resistance, LDL cholesterol and carotid IMT in healthy adults HEART 96: 1191-1200. 2010

Burgess DC, Hunt D, Li L, Zannino D, Williamson E, Davis TM, Laakso M, Kesäniemi YA, Zhang J, Sy RW, et al.. 2010. Incidence and predictors of silent myocardial infarction in type 2 diabetes and the effect of fenofibrate: an analysis from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study EUROPEAN HEART JOURNAL 31: 92-99. 2010

Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Kuusisto J, Laakso M, et al.. 2010. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. NATURE GENETICS 42: 105-116. 2010

Gylling H, Hallikainen M, Pihlajamaki J, Simonen P, Kuusisto J, Laakso M, Miettinen TA.. 2010. Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity. Lessons from the METSIM study.. JOURNAL OF LIPID RESEARCH 51: 2422-2427. 2010

Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, ..., Kuusisto J, ... , Laakso M, et al.. 2010. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. NATURE GENETICS 42: 949-960. 2010

Holman RR, Haffner SM, McMurray JJ, Bethel MA, Holzhauer B, Hua TA, Belenkov Y, Boolell M, Buse JB, ..., Laakso M, et al.. 2010. Effect of nateglinide on the incidence of diabetes and cardiovascular events. NEW ENGLAND JOURNAL OF MEDICINE 362: 1463-1476. 2010

Hietala K, Harjutsalo V, Forsblom C, Summanen P, Groop PH, FinnDiane Study Group. 2010. Age at onset and the risk of proliferative retinopathy in type 1 diabetes DIABETES CARE 33: 1315-1319. 2010

Ingelsson E, Langenberg C, Hivert MF, ProkopenkoI, Lyssenko V, Dupuis J, Mägi R, Sharp S, ..., Kuusisto J, Laakso M, et al. 2010. Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans. DIABETES (NY) 59: 1266-1275. 2010

Laakso M. 2010. Lipid disorders in type 2 diabetes Endocrinol Nutr 56: 43-45. 2010

Lorenzo C, Haffner SM, Stancakova A, Laakso M. 2010. Relation of direct and surrogate measures of insulin resistance to cardiovascular risk factors in nondiabetic Finnish offspring of type 2 diabetic individuals. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 95 11: 5082-5090. 2010

Juutilainen A, Lehto S, Suhonen M, Rönnemaa T, Laakso M. 2010. Thoracoabdominal calcifications predict cardiovascular disease mortality in type 2 diabetic and nondiabetic subjects. A 18-year follow-up study DIABETES CARE 33: 583-585. 2010

Laakso S, Utriainen P, Laakso M, Voutilainen R & Jääskeläinen J. 2010. Polymorphism Pro12Ala of PPARG in Prepubertal Children with Premature Adrenarche and Its Association with Growth in Healthy Children. HORMONE RESEARCH IN PAEDIATRICS 74: 365-371. 2010

Liu M, Shi S, Senthilnathan S, Yu J, Wu E, Bergmann C, Zerres K, Bogdanova N, Coto E, ..., Laakso M, et al.. 2010. Genetic Variation of DKK3 May Modify Renal Disease Severity in ADPKD. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 21: 1510-1520. 2010

Laakso M. 2010. Cardiovascular disease in type 2 diabetes. From population to man to mechanisms: Kelly West Lecture 2008. DIABETES CARE 33: 442-449. 2010

Kozakova M, Palombo C, Morizzo C, Nolan JJ, Konrad T, Balkau B, the RISC Investigtors. 2010. Effect of sedentary behaviour and vigorous physical activity on segment-specific carotid wall thickness and its progression in a healthy population. EUROPEAN HEART JOURNAL 31: 1511-1519. 2010

Kilpeläinen TO, Laaksonen DE, Lakka TA, Herder C, Koenig W, Lindström J, Eriksson JG, Uusitupa M, Kolb H, Laakso M, Tuomilehto J, for the Finnish Diabetes Prevention Study Group. 2010. The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish diabetes prevention study. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY AND DIABETES 118 10: 757-759. 2010

Rosengård-Bärlund M, Bernardi L, Fagerudd J, Mäntysaari M, Af Björkesten CG, Lindholm H, Forsblom C, Wadén J, Groop PH, FinnDiane Study Group, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Mykkänen L, Karhapää P. 2009. Early autonomic dysfunction in type 1 diabetes: a reversible disorder?. DIABETOLOGIA 52: 1164-1172. 2009

Müssig K, Staiger H, Machicao F, Stancáková A, Kuusisto J, Laakso M, Thamer C, Machann J, Schick F, Claussen CD, Stefan N, Fritsche A, Häring H-U. 2009. Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 94: 1353-1360. 2009

Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS..., Lucas G, Kuusisto J, Burton PR, Hadley D, McArdle WL, Wellcome TRUST Case Control Consortium, Brown M, Dominiczak A, Newhouse SJ, Samani NJ..., Laakso M. 2009. Genome-wide association study identifies eight loci associated with blood pressure. NATURE GENETICS 41: 666-676. 2009

Nymark M, Pussinen PJ, Tuomainen AM, Forsblom C, Groop PH, Lehto M, on behalf of the FinnDiane Study Group, Karhapää P, Laakso M, Lumiaho A, Moilanen L, Niskanen L, Vauhkonen I, Voutilainen E. 2009. Serum lipopolysaccharide activity is associated with the progression of kidney disease in finnish patients with type 1 diabetes. DIABETES CARE 32: 1689-1693. 2009

Plaisier CL, Kyttälä M, Weissglas-Volkov D, Sinsheimer JS, Huertas-Vazquez A..., Pullinger CR, Malloy MJ, Kane JP, Cruz-Bautista I, Herrera MF, Aguilar-Salinas C, Kuusisto J, Laakso M, Taskinen MR, van der Kallen CJ, Pajukanta P. 2009. Galanin preproprotein is associated with elevated plasma triglycerides. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 29: 147-152. 2009

Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, Kaakinen M, Lyssenko V, Chen WM, Ahmadi K..., Kuusisto J, Laakso M. 2009. Variants in MTNR1B influence fasting glucose levels. NATURE GENETICS 41: 77-81. 2009

Pulizzi N, Lyssenko V, Jonsson A, Osmond C, Laakso M, Kajantie E, Barker DJ, Groop LC, Eriksson JG. 2009. Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes. DIABETOLOGIA 52: 825-829. 2009

Rajamani K, Colman PG, Li LP, Best JD, Voysey M, D'Emden MC, Laakso M, Baker JR, Keech AC, on behalf of the FIELD Study Investigators. 2009. Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial. LANCET 373: 1780-1788. 2009

Lyssenko V, Nagorny CLF, Erdos MR, Wierup N, Jonsson A, Spégel P, Bugliani M, Saxena R, Fex M, Pulizzi N, Isomaa B, Tuomi T, Nilsson P, Kuusisto J, Tuomilehto J, Boehnke M..., Laakso M, Marchetti P, Watanabe RM, Mulder H, Groop L. 2009. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. NATURE GENETICS 41: 82-88. 2009

Salanti G, Southam L, Altshuler D, Ardlie K, Barroso I, Boehnke M, Cornelis MC, Frayling TM, Grallert H, Grarup N, Groop L, Hansen T, Hattersley AT, Hu FB, Hveem K, Illig T, Kuusisto J, Laakso M, Langenberg C.... 2009. Underlying genetic models of inheritance in established type 2 diabetes associations AMERICAN JOURNAL OF EPIDEMIOLOGY 170: 537-545. 2009

Salopuro T, Pulkkinen L, Lindström J, Kolehmainen M, Tolppanen A-M, Eriksson JG, Valle TT, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M, Salopuro T, Pulkkinen L, Kolehmainen M, Tolppanen A-M, Uusitupa M. 2009. Variation in the UCP2 and UCP3 genes associated with abdominal obesity and serum lipids: The Finnish diabetes prevention study. BMC MEDICAL GENETICS [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/BMCMEDGENET/] 10 94: [13 p.]. 2009

Stancáková A, Javorský M, Kuulasmaa T, Haffner SM, Kuusisto J, Laakso M. 2009. Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men. DIABETES (NY) 58: 1212-1221. 2009

Stancáková A, Kuulasmaa T, Paananen J, Jackson AU, Bonnycastle LL, Collins FS, Boehnke M, Kuusisto J, Laakso M. 2009. Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men. DIABETES (NY) 58: 2129-2136. 2009

Thorn LM, Forsblom C, Wadén J, Saraheimo M, Tolonen N, Hietala K, Groop P-H, for the Finnish Diabetic Nephropathy (FinnDiane) Study Group, Karhapää P, Laakso M, Moilanen L, Niskanen L, Vauhkonen I. 2009. Metabolic syndrome as a risk factor for cardiovascular disease, mortality, and progression of diabetic nephropathy in type 1 diabetes. DIABETES CARE 32: 950-952. 2009

Wadén J, Forsblom C, Thorn LM, Gordin D, Saraheimo M, Groop PH, on behalf of the Finnish Diabetic Nephropathy Study Group, Karhapää P, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Moilanen L. 2009. A1C variability predicts incident cardiovascular events, microalbuminuria, and overt diabetic nephropathy in patients with type 1 diabetes. DIABETES (NY) 58: 2649-2655. 2009

Wadén J, Forsblom C, Thorn LM, Saraheimo M, Rosengård-Bärlund M, Heikkilä O, Hietala K, Ong K, Wareham N, Groop PH, on behalf of the FinnDiane Study Group, Laakso M, Moilanen L, Niskanen L, Vauhkonen I, Voutilainen E. 2009. Adult stature and diabetes complications in patients with type 1 diabetes: the FinnDiane Study and the diabetes control and complications trial. DIABETES (NY) 58: 1914-1920. 2009

Weyrich P, Staiger H, Stancáková A, Schäfer SA, Kirchhoff K, Ullrich S, Ranta F, Gallwitz B, Stefan N, Machicao F, Kuusisto J, Laakso M, Fritsche A, Häring H-U. 2009. Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects. BMC MEDICAL GENETICS [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/BMCMEDGENET/] 10: 77. 2009

Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N..., Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Kuusisto J, Laakso M. 2009. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. NATURE GENETICS 41: 25-34. 2009

Meex SJR, Weissglas-Volkov D, van der Kallen CJH, Thuerauf DJ, van Greevenbroek MMJ, Schalkwijk CG, Stehouwer CDA, Feskens EJM, Heldens L, Ayoubi TA, Hofker MH, Wouters BG..., Taskinen M-R, Kuusisto J, Laakso M, de Bruin TWA.... 2009. The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 29: 1322-1327. 2009

Ahonen T, Saltevo J, Laakso M, Kautiainen H, Kumpusalo E, Vanhala M. 2009. Gender differences relating to metabolic syndrome and proinflammation in Finnish subjects with elevated blood pressure. MEDIATORS OF INFLAMMATION (ONLINE) 959281: [6 p.]. 2009

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM..., Cherkas L, Chines P, Coin L, Cooper C, Crawford G, Doering A, Dominiczak A, Doney..., Laakso M, Kuusisto J. 2009. Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution PLOS GENETICS [ONLINE) 5: e1000508. 2009

Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T..., Kuusisto J, Bergman RN..., Laakso M, Ferrucci L, Scheet P..., Dupuis J, de Bakker PI, O'Donnell CJ, Chambers JC, Kooner JS. 2009. Common variants at 30 loci contribute to polygenic dyslipidemia. NATURE GENETICS 41: 56-65. 2009

Li X, Shu Y-H, Xiang AH, Trigo E, Kuusisto J, Hartiala J, Swift AJ, Kawakubo M, Stringham HM, Bonnycastle LL, Lawrence JM, Laakso M, Allayee H, Buchanan TA, Watanabe RM. 2009. Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose DIABETES (NY) 58: 2946-2953. 2009

de Rooij SR, Dekker JM, Kozakova M, Mitrakou A, Melander O, Gabriel R, Guidone C, Højlund K, Murphy MS, Nijpels G, and the RISC Group Investigators, Laakso M. 2009. Fasting insulin has a stronger association with an adverse cardiometabolic risk profile than insulin resistance: the RISC study. EUROPEAN JOURNAL OF ENDOCRINOLOGY 161: 223-230. 2009

de Rooij SR, Nijpels G, Nilsson PM, Nolan JJ, Gabriel R, Bobbioni-Harsch E, Mingrone G, Dekker JM, for the Relationship Between Insulin Sensitivity And Cardiovascular, Disease (risc) Investigators, Laakso M. 2009. Low-grade chronic inflammation in the relationship between insulin sensitivity and cardiovascular disease (RISC) population: associations with insulin resistance and cardiometabolic risk profile. DIABETES CARE 32: 1295-1301. 2009

Gastaldelli A, Kozakova M, Hojlund K, Flyvbjerg A, Favuzzi A, Mitrakou A, Balkau B, the RISC Investigators, Laakso M. 2009. Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population. HEPATOLOGY 49: 1537-1544. 2009

Groop PH, Thomas MC, Moran JL, Wadèn J, Thorn LM, Mäkinen V-P, Rosengård-Bärlund M, Saraheimo M, Hietala K, Heikkilä O, Forsblom C, on behalf of the FinnDiane Study Group, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Mykkänen L, Karhapää P. 2009. The presence and severity of chronic kidney disease predicts all-cause mortality in type 1 diabetes DIABETES (NY) 58: 1651-1658. 2009

Gylling H, Hallikainen M, Rajaratnam RA, Simonen P, Pihlajamäki J, Laakso M, Miettinen TA. 2009. The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease. METABOLISM: CLINICAL AND EXPERIMENTAL 58: 401-407. 2009

Heikkinen S, Argmann C, Feige JN, Koutnikova H, Champy M-F, Dali-Youcef N, Schadt EE, Laakso M, Auwerx J. 2009. The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface 9: 88-98. 2009

Honka M-J, Vänttinen M, Iozzo P, Virtanen KA, Lautamäki R, Hällsten K, Borra RJH, Takala T, Viljanen APM, Kemppainen J, Pihlajamäki J, Knuuti J, Nuutila P, Laakso M. 2009. The Pro12Ala polymorphism of the PPARgamma2 gene is associated with hepatic glucose uptake during hyperinsulinwmia in subjects with type 2 diabetes mellitus. METABOLISM: CLINICAL AND EXPERIMENTAL 58: 541-546. 2009

Boesgaard TW, Gjesing AP, Grarup N, Rutanen J, Jansson P-A, Hribal ML, Sesti G, Fritsche A, Stefan N, Staiger H, Häring H, Smith U, Laakso M, Pedersen O, Hansen T, for the EUGENE2 Consortium. 2009. Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients-EUGENE2 study PLOS ONE [ONLINE] 4: e7236. 2009

Kaunisto MA, Sjölind L, Sallinen R, Pettersson-Fernholm K, Saraheimo M, Fröjdö S, Forsblom C, Fagerudd J, Hansen TK, Flyvbjerg A, Wessman M, Groop PH, FinnDiane Study Group, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Mykkänen L, Karhapää P. 2009. Elevated MBL concentrations are not an indication of association between the MBL2 gene and type 1 diabetes or diabetic nephropathy. DIABETES (NY) 57: 1710-1714. 2009

Laakso M. 2009. Not for the eyes only: PAX6 and glucose metabolism. DIABETOLOGIA 52: 381-384. 2009

Kilhovd BK, Juutilainen A, Lehto S, Rönnemaa T, Torjesen PA, Hanssen KF, Laakso M. 2009. Increased serum levels of methylglyoxal-derived hydroimidazolone-AGE are associated with increased cardiovascular disease mortality in nondiabetic women. ATHEROSCLEROSIS 205: 590-594. 2009

Langenberg C, Pascoe L, Mari A, Tura A, Laakso M, Frayling TM, Barroso I, Loos RJF, Wareham NJ, Walker M, the RISC Consortium. 2009. Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response DIABETOLOGIA 52: 1537-1542. 2009

Lappalainen S, Voutilainen R, Utriainen P, Laakso M, Jääskeläinen J. 2009. Genetic variation of FTO and TCF7L2 in premature adrenarche METABOLISM: CLINICAL AND EXPERIMENTAL 58: 1263-1269. 2009

Laakso M. 2009. Natural history of type 2 diabetes and macrovascular disease: Serrano-Riós M, Gutiérrez-Fuentes JA, Type 2 Diabetes Mellitus.Elsevier. 151-166. 2009

Laakso M. 2009. Endokriinisten sairauksien geenidiagnostiikka: Välimäki M, Sane T, Dunkel L, Endokrinologia.Duodecim. 50-62. 2009

Koutnikova H, Laakso M, Lu L, Combe R, Paananen J, Kuulasmaa T, Kuusisto J, Häring H-U, Hansen T, Pedersen O, Smith U, Hanefeld M, Williams RW, Auwerx J. 2009. Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics. PLOS GENETICS [ONLINE) 5: e100591. 2009

Kong A, Steinthorsdottir V, Masson G, Thorleifsson G..., ...Johannsson OT, Hreidarsson AB, Sigurdsson G, DIAGRAM Consortium, Laakso M, Kuusisto J. 2009. Parental origin of sequence variants associated with complex diseases NATURE (LONDON) 462: 868-874. 2009

Shaw JE, Punjabi NM, Wilding JP, Alberti KGMM, Zimmet PZ, Laakso M. 2008. Sleep-disordered breathing and type 2 diabetes. A report from the International Diabetes Federation Taskforce on Epidemiology and Prevention DIABETES RESEARCH AND CLINICAL PRACTICE 81: 2-12. 2008

Miettinen KH, Lassus J, Harjola VP, Siirilä-Waris K, Melin J, Punnonen KR, Nieminen MS, Laakso M, Peuhkurinen KJ. 2008. Prognostic role of pro- and anti-inflammatory cytokines and their polymorphisms in acute decompensated heart failure EUROPEAN JOURNAL OF HEART FAILURE 10 4: 396-403. 2008

Mäkinen V-P, Forsblom C, Thorn LM, Wadén J, Gordin D, Heikkilä O, Hietala K, Kyllönen L, Kytö J, Rosengård-Bärlund M, Saraheimo M, Tolonen N, Parkkonen M, Kaski K, Ala-Korpela M, Groop P-H, on behalf of the FinnDiane Study Group, Huttunen E. 2008. Metabolic phenotypes, vascular complications, and premature deaths in a population of 4,197 patients with type 1 diabetes. DIABETES (NY) 57: 2480-2487. 2008

Patel S, Flyvbjerg A, Kozàkovà M, Frystyk J, Ibrahim IM, Petrie JR, Avery PJ, Ferrannini E, Walker M, RISC Investigators, Laakso M. 2008. Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects. EUROPEAN HEART JOURNAL 29: 386-393. 2008

Ruotsalainen E, Vauhkonen I, Salmenniemi U, Pihlajamäki J, Punnonen K, Kainulainen S, Jalkanen S, Salmi M, Laakso M. 2008. Markes of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects. ATHEROSCLEROSIS 197: 271-277. 2008

Saltevo J, Laakso M, Jokelainen J, Keinänen-Kiukaanniemi S, Kumpusalo E, Vanhala M. 2008. Levels of adiponectin, C-reactive protein and interleukin-1 receptor antagonist are associated with insulin sensitivity: a population-based study. DIABETES, METABOLISM RESEARCH AND REVIEWS 24: 378-383. 2008

Saltevo J, Vanhala M, Kautiainen H, Kumpusalo E, Laakso M. 2008. Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study. DIABETIC MEDICINE 25: 747-750. 2008

Saraheimo M, Forsblom C, Thorn L, Wadén J, Rosengård-Bärlund M, Heikkilä O, Hietala K, Gordin D, Frystyk J, Flyvbjerg A, Groop PH, on behalf of the FINNDIANE Study Group, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Mykkänen L, Karhapää P. 2008. Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes. DIABETES CARE 31: 1165-1169. 2008

Ungaro P, Teperino R, Mirra P, Cassese A, Fiory F, Perruolo G, Miele C, Laakso M, Formisano P, Beguinot F. 2008. Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II. JOURNAL OF BIOLOGICAL CHEMISTRY 283: 30970-30979. 2008

Staiger H, Stancáková A, Zilinskaite J, Vänttinen M, Hansen T, Marini MA, Hammarstedt A, Jansson P-A, Sesti G, Smith U, Pedersen O, Laakso M, Stefan N, Fritsche A, Häring H-U. 2008. A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study. DIABETES (NY) 57: 514-517. 2008

Stancáková A, Pihlajamäki J, Kuusisto J, Stefan N, Fritsche A, Häring H, Andreozzi F, Succurro E, Sesti G, Boesgaard TW, Hansen T, Pedersen O, Jansson PA, Hammarstedt A, Smith U, Laakso M, for the EUGENE2 Consortium. 2008. Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 93 5: 1924-1930. 2008

The DREAM Trial Investigators, Laakso M. 2008. Effects of ramipril and rosiglitazone on cardiovascular and renal outcomes in people with impaired glucose tolerance or impaired fasting glucose. Results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial. DIABETES CARE 31: 1007-1014. 2008

Tolonen N, Forsblom C, Thorn L, Wadén J, Rosengård-Bärlund M, Saraheimo M, Heikkilä O, Pettersson-Fernholm K, Taskinen MR, Groop PH, FinnDiane Study Group, Karhapää P, Laakso M, Mykkänen L, Niskanen L, Vauhkonen I, Voutilainen E. 2008. Relationship between lipid profiles and kidney function in patients with type 1 diabetes DIABETOLOGIA 51: 12-20. 2008

Wadén J, Forsblom C, Thorn LM, Saraheimo M, Rosengård-Bärlund M, Heikkilä O, Lakka TA, Tikkanen H, Groop PH, FinnDiane Study Group, Karhapää P, Laakso M, Moilanen L, Niskanen L, Vauhkonen I, Voutilainen E. 2008. Physical activity and diabetes complications in patients with type 1 diabetes. The Finnish Diabetic Nephropathy (FinnDiane) Study. DIABETES CARE 31: 230-232. 2008

Wang J, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M, Kuusisto J. 2008. The metabolic syndrome predicts incident stroke: a 14-year follow-up study in elderly people in Finland. STROKE 39: 1078-1083. 2008

Zeggini E, Scott LJ, Saxena R, Voight BF, for the Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Laakso M, Kuusisto J. 2008. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. NATURE GENETICS 40 5: 638-645. 2008

Lindi V, Schwab U, Louheranta A, Vessby B, Hermansen K, Tapsell L, Riccardi G, Rivellese AA, Laakso M, Uusitupa MIJ, KANWU Study Group. 2008. The G-250A polymorphism in the hepatic lipase gene promotor is associated with changes in hepatic lipase activity and LDL cholesterol:The KANWU study. NUTRITION, METABOLISM AND CARDIOVASCULAR DISEASES 18: 88-95. 2008

Liu X-Q, Paterson AD, He N, St George-Hyslop P, Rauta V, Gronhagen-Riska C, Laakso M, Thibaudin L, Berthoux F, Cattran D, Pei Y. 2008. IL5RA and TNFRSF6B gene variants are associated with sporadic IgA nephropathy. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 19: 1025-1033. 2008

Bakris G, Böhm M, Dagenais G, Diener H-C, Fujita T, Gorelick P, Kjeldsen SE, Laakso M, Mancia G, Pitt B, Sharma A, Sleight P, Teo K, Unger T, Weber M, Williams B, Zannad F. 2008. Cardiovascular protection for all individuals at high risk: evidence-based best practice CLINICAL REARCH IN CARDIOLOGY 97: 713-725. 2008

Lee JC, Weissglas-Volkov D, Kyttäjä M, Dastani Z, Cantor RM, Sobel EM, Plaisier CL, Engert JC, van Greenvenbroek MMJ, Kane JP, Malloy MJ..., Kuusisto J, Laakso M, Taskinen M-R, Genest J, Pajukanta P. 2008. WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels. AMERICAN JOURNAL OF HUMAN GENETICS 83: 180-192. 2008

Hammerstedt A, Pihlajamäki J, Graham TE, Kainulainen S, Kahn BB, Laakso M, Smith U. 2008. High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects. JOURNAL OF INTERNAL MEDICINE 263: 440-449. 2008

Balkau B, Mhamdi L, Oppert J-M, Nolan J, Golay A, Porcellati F, Laakso M, Ferrannini E, on behalf of the EGIR-RISC Study Group. 2008. Physical activity and insulin sensitivity: the RISC Study. DIABETES (NY) 57: 2613-2618. 2008

Boesgaard TW, Zilinskaite J, Vänttinen M, Laakso M, Jansson P-A, Hammarstedt A, Smith U, Stefan N, Fritsche A, Häring H, Hribal M, Sesti G, Zobel DP, Pedersen O, Hansen T, for the EUGENE 2 Consortium. 2008. The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients - the EUGENE2 study. DIABETOLOGIA 51: 816-820. 2008

Bonnet F, Patel S, Laville M, Balkau B, Favuzzi A, Monti LD, Lalic N, Walker M, European GROUP For the Study of Insulin Resistance Relationship Between Insulin Sensitivity And Cardiovascular Disease Risk Study Group., Laakso M. 2008. Influence of the ACE gene insertion/deletion polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects. DIABETES CARE 31: 789-794. 2008

Califf RM, Boolell M, Haffner SM, Bethel MA, McMurray J, Duggal A, Holman RR, for the NAVIGATOR Study Group, Laakso M. 2008. Prevention of diabetes and cardiovascular disease in patients with impaired glucose tolerance: rationale and design of the Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) Trial. AMERICAN HEART JOURNAL 156: 623-632. 2008

Chen W-M, Erdos MR, Jackson AU..., Kuusisto J, Ebrahim S..., Laakso M. 2008. Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. JOURNAL OF CLINICAL INVESTIGATION 118: 2620-2628. 2008

Chibalin AV, Leng Y, Vieira E, Krook A, Björnholm M, Long YC, Kotova O, Zhong Z, Sakane F, Steiler T, Nylén C, Wang J, Laakso M, Topham MK, Gilbert M, Wallberg-Henriksson H, Zierath JR. 2008. Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance. CELL 132: 375-386. 2008

Friedrich B, Weyrich P, Stancakova A, Wang J, Kuusisto J, Laakso M, Sesti G, Succurro E, Smith U, Hansen T, Pedersen O, Machicao F, Schäfer S, Lang F, Risler T, Ullrich S, Stefan N, Fritsche A, Häring H-U. 2008. Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, AND METSIM studies PLOS ONE [ONLINE] 3 11: e3506. 2008

Laitinen T, Lyyra-Laitinen T, Huopio H, Vauhkonen I, Halonen T, Hartikainen J, Niskanen L, Laakso M. 2008. Electrocardiographic alterations during hyperinsulinemic hypoglycemia in healthy subjects. ANNALS OF NONINVASIVE ELECTROCARDIOLOGY 13 2: 97-105. 2008

Helisalmi S, Vepsäläinen S, Hiltunen M, Koivisto AM, Salminen A, Laakso M, Soininen H, Soininen H. 2008. Genetic study between SIRT1, PPARD, PGC-1alfa genes and Alzheimer's disease. JOURNAL OF NEUROLOGY 255: 668-673. 2008

Kilpeläinen TO, Lakka TA, Laakosnen DE, Mager U, Salopuro T, Kubaszek A, Todorova B, Laukkanen O, Lindström J, Eriksson JG, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M. 2008. Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome. The Finnish Diabetes Prevention Study. METABOLISM: CLINICAL AND EXPERIMENTAL 57: 428-436. 2008

Kilpeläinen TO, Lakka TA, Laaksonen DE, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Lindi V, Tuomilehto J, Uusitupa M, Laakso M. 2008. SNPs in PPARG associte with type 2 diabetes and intract with physival activity. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 40: 25-33. 2008

Koikkalainen JR, Antila M, Lötjönen JMP, Heliö T, Lauerma K, Kivistö SM, Sipola P, Kaartinen MA, Kärkkäinen STJ, Reissell E, Kuusisto J, Laakso M, Oresic M, Nieminen MS, Peuhkurinen KJ. 2008. Early familial dilated cardiomyopathy: Identification with determination of disease state parameter from cine MR image data. RADIOLOGY 249 1: 88-96. 2008

Kozakova M, Palombo C, Paterni M, Anderwald CH, Konrad T, Colgan MP, Flyvbjerg A, Dekker J, Relationship between Insulin Sensitivity Cardiovascular Risk Investigators, Laakso M. 2008. Body composition and common carotid artery remodeling in a healthy population. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 93: 3325-3332. 2008

Laakso M, Zilinskaite J, Hansen T, Boesgaard TW, Vänttinen M, Stancáková A, Jansson P-A, Pellmé F, Holst JJ, Kuulasmaa T, Hribal ML, Sesti G, Stefan N, Fritsche A, Häring H, Pedersen O, Smith U, for the EUGENE2 Consortium. 2008. Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study. DIABETOLOGIA 51: 502-511. 2008

Laakso M. 2008. Diabetes as a 'cardiovascular disease equivalent': implications for treatment. NATURE CLINICAL PRACTICE. CARDIOVASCULAR MEDICINE 5 11: 682-683. 2008

Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. 2008. Similarity of the impact of type 1 and type 2 diabetes on cardiovascular mortality in middle-aged subjects. DIABETES CARE 31: 714-719. 2008

Soinio M, Marniemi J, Laakso M, Pyörälä K, Lehto S, Rönnemaa T. 2007. Serum zinc level and coronary heart disease events in patients with type 2 diabetes. DIABETES CARE 30: 523-528. 2007

Pirinen E, Kuulasmaa T, Pietilä M, Heikkinen S, Tusa M, Itkonen P, Boman S, Skommer J, Virkamäki A, Hohtola E, Kettunen M, Fatrai S, Kansanen E, Koota S, Niiranen K, Parkkinen J, Levonen A-L, Ylä-Herttuala S, Hiltunen JK, Alhonen L, Smith U, Jänne J. 2007. Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism MOLECULAR AND CELLULAR BIOLOGY 27 13: 4953-4967. 2007

Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Kuusisto J, Laakso M. 2007. Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans. OBESITY (SILVER SPRING, MD.) 15: 2902-2907. 2007

Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Laakso M, Laakso M. 2007. Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 92: 1112-1117. 2007

Rydén L, Standl E, Bartnik M, Van den Berghe G, Betteridge J, de Boer MJ, Cosentino F, Jönsson B, Laakso M, Malmberg K, Priori S, Östergren J, Tuomilehto J, Thrainsdottir I, Vanhorebeek I, Stramba-Badiale M, Lindgren P, Qiao Q, Priori SG, Blanc JJ, Budaj A, Camm J, Dean V, Deckers J, Dickstein K, Lekakis J, Mcgregor K, Metra M, Morais J, Osterspey A, Tamargo J, Zamorano JL, Deckers JW, Bertrand M,. 2007. Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary: The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). EUROPEAN HEART JOURNAL 28: 88-136. 2007

Saltevo J, Vanhala M, Kautiainen H, Kumpusalo E, Laakso M. 2007. Association of C-reactive protein, interleukin-1 receptor antagonist and adiponectin with the metabolic syndrome MEDIATORS OF INFLAMMATION (ONLINE): Article ID 93573. 2007

Saltevo J, Vanhala M, Kautiainen H, Laakso M. 2007. Levels of adiponectin, C-reactive protein and interleukin-1 receptor antagonist are associated with the relative change in body mass index between childhood and adulthood DIABETES AND VASCULAR DISEASE RESEARCH 4: 328-331. 2007

Sittiwet C, Gylling H, Hallikainen M, Pihlajamäki J, Moilanen L, Laaksonen DE, Niskanen L, Ågren JJ, Laakso M, Miettinen TA. 2007. Cholesterol metabolism and non-cholesterol sterol distribution in lipoproreins of type 1 diabetes: The effect of improved glycemic control. ATHEROSCLEROSIS 194: 465-472. 2007

Tuunanen H, Kuusisto J, Toikka J, Jääskeläinen P, Marjamäki P, Peuhkurinen K, Viljanen T, Sipola P, Stolen KQ, Hannukainen J, Nuutila P, Laakso M, Knuuti J, Laakso M. 2007. Myocardial perfusion, oxidative metabolism, and free fatty acid uptake in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene: a positron emission tomography study. JOURNAL OF NUCLEAR CARDIOLOGY 14 3: 354-365. 2007

Staiger H, Machicao F, Machann J, Schick F, Kuulasmaa T, Laakso M, Fritsche A, Stefan N, Häring H-U, Laakso M. 2007. Genetic variation within the APPL locus is not associated with metabolic or inflammatory traits in a healthy white population. DIABETIC MEDICINE 24: 817-822. 2007

Stefan N, Thamer C, Staiger H, Machicao F, Machann J, Shick F, Venter C, Niess A, Laakso M, Fritsche A, Häring H-U, Laakso M. 2007. Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic pysical fitness and insulin sensitivity during lifestyle intervention. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 92: 1827-1833. 2007

Suomalaisen Lääkäriseuran Duodecimin, Diabetesliiton Lääkärineuvoston, ja Suomen Sisätautilääkärien Yhdistyksen Asettama Työryhmä, Laakso M, Louheranta A. 2007. Diabeteksen Käypä hoito -suositus. DUODECIM 123: 1490-1520. 2007

Thorn LM, Forsblom C, Fagerudd J, Pettersson-Fernholm K, Kilpikari R, Groop PH, on behalf of the FinnDiane Study Group, Huttunen E, Karhapää P, Laakso M, Moilanen L, Niskanen L, Vauhkonen I, Voutilainen E. 2007. Clustering of risk factors in parents of patients with type 1 diabetes and nephropathy DIABETES CARE 30: 1162-1167. 2007

Wadén J, Thorn LM, Forsblom C, Lakka T, Saraheimo M, Rosengård-Bärlund M, Heikkilä O, Wessman M, Turunen JA, Parkkonen M, Tikkanen H, Groop P-H, on behalf of the FinnDiane Study Group. 2007. Leisure-time physical activity is associated with the metaboic syndrome in type 1 diabetes: Effect of the PPAR-gamma Pro12Ala polymorphism: the FinnDiane Study. DIABETES CARE 30: 1618-1620. 2007

Wang J, Kuusisto J, Vänttinen M, Kuulasmaa T, Lindström J, Tuomilehto J, Uusitupa M, Laakso M, Laakso M. 2007. Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion. DIABETOLOGIA 50: 1192-1200. 2007

Wang J, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M, Kuusisto J. 2007. Metabolic syndrome and incident end-stage peripheral vascular disease. A 14-year follow-up study in elderly Finns. DIABETES CARE 30: 3099-3104. 2007

Wang J, Ruotsalainen S, Moilanen L, Lepistö P, Laakso M, Kuusisto J. 2007. The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns. EUROPEAN HEART JOURNAL 28: 857-864. 2007

Laakso M. 2007. Challenges in studies of the genetic basis of type 2 diabetes. EXPERT REVIEW OF ENDOCRINOLOGY AND METABOLISM 2 4: 451-459. 2007

Laakso M. 2007. Prevention of cardiovascular events in diabetic patients: Fisher M, McMurray JJ, Diabetic Cardiology.John Wiley & Sons. 221-239. 2007

Weyrich P, Stefan N, Häring H-U, Laakso M, Fritsche A. 2007. Effect of genotype on success of lifestyle intervention in subjects at risk for type 2 diabetes. JOURNAL OF MOLECULAR MEDICINE 85: 107-117. 2007

Laakso M, Uusitupa M. 2007. Tyypin 2 diabeteksen ehkäisy. DUODECIM 123: 1439-1447. 2007

Heinonen SE, Leppänen P, Kholová I, Lumivuori H, Häkkinen S-K, Bosch F, Laakso M, Ylä-Herttuala S, Kholova I, Laakso M. 2007. Increased atherosclerotic lesion calcification in a novel mouse model combining insulin resistance, hyperglycemia, and hypercholesterolemia. CIRCULATION RESEARCH 101: 1058-1067. 2007

Andrulionyté L, Kuulasmaa T, Chiasson J-L, Laakso M, for the STOPP-NIDDM Study Group, Laakso M. 2007. Single nucleotide polymorphisms of the peroxisome proliferator-activated receptor-alpha gene (PPARA) influence the conversion from impaired glucose tolerance to type 2 diabetes. The STOP-NIDDM Trial. DIABETES (NY) 56: 1181-1186. 2007

Laakso M, Laakso M. 2007. Sirtuiinit - energiatasapainon ja glukoosimetabolian uudet molekyylit DUODECIM 123: 2291-2292. 2007

Erdmann E, Charbonnel B, Wilcox RG, Skene AM, Massi-Benedetti M, Yates J, Tan M, Spanheimer R, Standl E, Dormandy JA, on behalf of the PROactive Investigators, Laakso M, Laakso M. 2007. Pioglitazone use and heart failure in patients with type 2 diabetes and preexisting cardiovascular disease. Data from the PROactive Study (PROactive 08). DIABETES CARE 30: 2773-2778. 2007

Erdmann E, Dormandy JA, Charbonnel B, Massi-Benedetti M, Moules IK, Skene AM, on behalf of the PROactive Investigators, Laakso M. 2007. The effect of pioglitazone on recurrent myocardial infaraction in 2,445 patients with type 2 diabetes and previous myocardial infarction. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 49: 1772-80. 2007

Ferrannini E, Balkau B, Coppack SW, Dekker JM, Mari A, Nolan J, Walker M, Natali A, Beck-Nielsen H, and the RISC investigators, Laakso M, Räisänen R, Ruotsalainen U, Laitinen M, Saloranta H. 2007. Insulin resistance, insulin response, and obesity as indicators of metabolic risk. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 92: 2885-2892. 2007

Ferrannini E, Muscelli E, Natali A, Gabriel R, Mitrakou A, Flyvbjerg A, Golay A, Hojlund K, the Relationship between Insulin Sensitivity, Laakso M, Räisänen R, Ruotsalainen U, Laitinen M, Saloranta H. 2007. Association of fasting glucagon and proinsulin concentrations with insulin resistance. DIABETOLOGIA 50: 2342-2347. 2007

Fueger PT, Lee-Young RS, Shearer J, Bracy DP, Heikkinen S, Laakso M, Rottman JN, Wasserman DH. 2007. Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat-fed mice. Studies in mice with a 50 % reduction of hexokinase II. DIABETES (NY) 56: 2476-2484. 2007

Gylling H, Hallikainen M, Kolehmainen M, Toppinen L, Pihlajamäki J, Mykkänen H, Ågren JJ, Rauramaa R, Laakso M, Miettinen TA. 2007. Cholesterol synthesis prevails over absorption in metabolic syndrome. TRANSLATIONAL RESEARCH 149: 310-316. 2007

Dahlman I, Dicker A, Jiao H, Kere J, Blomqvist L, van Harmelen V, Hoffstedt J, Borch-Johnsen K, Jörgensen T, Hansen T, Pedersen O, Laakso M, Arner P, Laakso M. 2007. A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis. AMERICAN JOURNAL OF HUMAN GENETICS 80: 1115-1124. 2007

Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. 2007. Retinopathy predicts cardiovascular mortality in type 2 diabetic men and women. DIABETES CARE 30: 292-299. 2007

Kuusisto J, Andrulionyte L, Laakso M, Laakso M. 2007. Atherosclerosis and cardiovascular risk reduction with PPAR agonists. CURRENT ATHEROSCLEROSIS REPORTS 9: 274-280. 2007

Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. 2007. Retinopathy predicts cardiovascular mortality in type 2 diabetic men and women. DIABETES CARE 30: e52. 2007

Laakso M, Kuusisto J. 2007. Cerebrovascular disease in type 2 diabetes: Grepaldi G, Tiengo A, Avogaro A, The Metabolic Syndrome: The Road Map from Inflammation to Cardiovascular Disease. Proceedings ot the 9th European Symposium on Metabolism. International Congress Series. 65-69. 2007

Laakso M, Groop L. 2007. Yksi, kaksi vai monta diabetesta?. DUODECIM 123: 1427-1429. 2007

Laakso M, Laakso M. 2007. Diabetes - glukoosiaineenvaihdunnan säätelyn perinnöllinen häiriö. DUODECIM 123: 2195-2204. 2007

Kozakova M, Palombo C, Mhamdi L, Konrad T, Nilsson P, Staehr PB, Paterni M, Balkau B, on behalf of the RISC Investigators, Laakso M, Räisänen R, Ruotsalainen U, Laitinen M, Saloranta H. 2007. Habitual physical activity and vascular aging in a young to middle-age population at low cardiovascular risk. STROKE 38: 2549-2555. 2007

Kilpeläinen TO, Lakka TA, Laaksonen DE, Laukkanen O, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, for the Finnish Diabetes Prevention Study Group, Laakso M. 2007. Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes. PHYSIOLOGICAL GENOMICS (PRINTED AND ONLINE) 31: 264-272. 2007

Kilhovd BK, Juutilainen A, Lehto S, Rönnemaa T, Torjesen PA, Hanssen KF, Laakso M. 2007. Increased serum levels of advanced glycation endproducts predict total, cardiovascular and coronary mortality in women with type 2 diabetes: a population-based 18 year follow-up study. DIABETOLOGIA 50: 1409-1417. 2007

Keech AC, Mitchell P, Summanen PA, O¿Day J, Davis TME, Moffitt MS, Taskinen M-R, Simes RJ, Tse D, Williamson E, Merrifield A, Laatikainen LT, d¿Emden MC, Crimert DC, O¿Connell RL, Colman PG, for the Field study investigators, Laakso M. 2007. Effect of fenofibrate on the need for treatment for diabetic retinopathy (FIELD study): a randomised controlled trial. LANCET 370: 1687-1697. 2007

Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M, Laakso M, Hiltunen M, Helisalmi S. 2006. Adiponectin gene haplotype is associated with preeclampsia. GENETIC TESTING 10 1: 35-39. 2006

Otonkoski T, Näntö-Salonen K, Seppänen M, Veijola R, Huopio H, Hussain K, Tapanainen P, Eskola O, Parkkola R, Ekström K, Guiot Y, Rahier J, Laakso M, Rintala R, Nuutila P, Minn H. 2006. Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography. DIABETES (NY) 55: 13-18. 2006

Peltola P, Pihlajamäki J, Koutnikova H, Ruotsalainen E, Salmenniemi U, Vauhkonen I, Kainulainen S, Gylling H, Miettinen TA, Auwerx J, Laakso M, Laakso M. 2006. Visceral obesity is associated with high levels of serum squalene. OBESITY (SILVER SPRING, MD.) 14: 1155-1163. 2006

Pihlajamäki J, Salmenniemi U, Vänttinen M, Ruotsalainen E, Kuusisto J, Vauhkonen I, Kainulainen S, Ng MCY, Cox NJ, Bell CI, Laakso M, Laakso M. 2006. Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes. DIABETOLOGIA 49: 1560-1566. 2006

Poutanen T, Tikanoja T, Jääskeläinen P, Jokinen E, Silvast A, Laakso M, Kuusisto J, Laakso M. 2006. Diastolic dysfunction without left ventricular hypertrophy is an early finding in children with hypertrophic cardiomyopathy-causing mutations in the beeta-myosin heavy chain, alfa-tropomyosin, and myosin-binding protein C genes. AMERICAN HEART JOURNAL [ONLINE: HTTP:WWW.MOSBY.COM/AHJ] 151: 725.e1-725.e9. 2006

Roy H, Bhardwaj S, Babu M, Kokina I, Uotila S, Ahtialansaari T, Laitinen T, Hakumaki J, Laakso M, Herzig K-H, Ylä-Herttuala S. 2006. VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits [FJ Express Full-Length Article]. FASEB JOURNAL [ONLINE] 20: E1550-E1559. 2006

Roy H, Bhardwaj S, Babu M, Kokina I, Uotila S, Ahtialansaari T, Laitinen T, Hakumäki J, Laakso M, Herzig K-H, Ylä-Herttuala S. 2006. VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits FASEB JOURNAL 20: 2159-2161. 2006

Ruotsalainen E, Salmenniemi U, Vauhkonen I, Pihlajamäki J, Punnonen K, Kainulainen S, Laakso M. 2006. Changes in inflammatory cytokines are related to impaired glucose tolerance in offspring of type 2 diabetic subjects. DIABETES CARE 29 12: 2714-2720. 2006

Smith U, Laakso M, Eliasson B, Wesslau C, Borén J, Wiklund O, Attvall S. 2006. Pathogenesis and treatment of diabetic vascular disease - illustrated by two cases. JOURNAL OF INTERNAL MEDICINE 260: 409-420. 2006

Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M, Laakso M, Hiltunen M, Helisalmi S. 2006. Plasma cell membrane glycoprotein-1 K121Qmpolymorphism in preeclampsia. GYNECOLOGIC AND OBSTETRIC INVESTIGATION 61: 124-127. 2006

Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M, Laakso M, Hiltunen M, Helisalmi S. 2006. Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia. EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND REPRODUCTIVE BIOLOGY 128: 175-179. 2006

Siitonen N, Pulkkinen L, Mager U, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M, for the Finnish diabetes prevention study group, Siitonen N, Pulkkinen L, Mager U. 2006. Association of sequence variations in the gene encoding adoponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish diabetes prevention study DIABETOLOGIA 49: 1795-1805. 2006

Sipola P, Peuhkurinen K, Lauerma K, Husso M, Jääskeläinen P, Laakso M, Aronen HJ, Risteli J, Kuusisto J, Laakso M. 2006. Myocardial late gadolinium enhancement is associated with raised serum amino-terminal propeptide of type III collagen concentrations in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha tropomyosin gene:. HEART 92: 1321-1322. 2006

Soinio M, Marniemi J, Laakso M, Lehto S, Rönnemaa T. 2006. High-sensitivity C-reactive protein and coronary heart disease mortality in patients with type 2 diabetes: a 7-year follow-up study DIABETES CARE 29: 329-333. 2006

The DREAM Trial Investigators, Laakso M, Rutanen J, Jantunen A. 2006. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. LANCET 368: 1096-1105. 2006

The DREAM Trial Investigators, Laakso M. 2006. Effect of ramipril on the incidence of diabetes. NEW ENGLAND JOURNAL OF MEDICINE 355: 1551-1562. 2006

Vanhanen M, Koivisto K, Moilanen L, Helkala E-L, Hänninen T, Soininen H, Kervinen K, Kesäniemi YA, Laakso M, Kuusisto J, Soininen H. 2006. Association of metabolic syndrome with Alzheimer disease: a population-based study. NEUROLOGY 67: 843-847. 2006

Niiranen K, Keinänen TA, Pirinen E, Heikkinen S, Tusa M, Fatrai S, Suppola S, Pietilä M, Uimari A, Laakso M, Alhonen L, Jänne J. 2006. Mice with targeted disruption of spermidine/spermine N1-acetyltransferese gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 10: 933-945. 2006

Mousavinasab F, Tähtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Laakso M, Keinänen-Kiukaanniemi S. 2006. The pro12Ala polymorphism of the PPAR gamma 2 gene influences sex hormone binding globulin level and its relationship to the development of the metabolic syndrome in young Finnish men ENDOCRINE 30: 185-190. 2006

Mousavinasab F, Tähtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Keinänen-Kiukaanniemi S, Laakso M, Laakso M. 2006. Common polymorphisms (single-nucleotide polymorphisms SNP+45 and SNP+276) of the adiponectin gene regulate serum adiponectin concentrations and blood pressure in young Finnish men. MOLECULAR GENETICS AND METABOLISM (ARLANDO) 87: 147-151. 2006

Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma V-M, Naukkarinen A, Laakso M. 2006. Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 41: 191-199. 2006

Mager U, Lindi V, Lindström J, Eriksson JG, Vallet TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Pulkkinen L, Uusitupa M, for the Finnish diabetes prevention study group, Mager U, Lindi V, Pulkkinen L. 2006. Association of the Leu72Met polymorphism of the ghrelin gene with the risk of type 2 diabetes in subjects with impaired glucose tolerance in the Finnish diabetes prevention study DIABETIC MEDICINE 23: 685-689. 2006

Andrulionyté L, Laukkanen O, Chiasson J-L, Laakso M, STOP-NIDDM Study Group, Laakso M. 2006. Single nucleotide polymorphisms of the HNF4alfa gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trial. JOURNAL OF MOLECULAR MEDICINE 84: 701-708. 2006

Andrulionyté L, Peltola P, Chiasson J-L, Laakso M, for the STOP-NIDDM Study Group. 2006. Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM Trial. DIABETES (NY) 55: 2148-2152. 2006

Fagerudd J, Forsblom C, Pettersson-Fernholm K, Saraheimo M, Wadén J, Rönnback M, Rosengård-Bärlund M, af Björkesten C-G, Thorn L, Wessman M, Groop P-H, on behalf of the FinnDiane Study Group, Laakso M, Karhapää P, Mykkänen L, Niskanen L, Vauhkonen I. 2006. Low birth weight does not increase the risk of nephropathy in Finnish type 1 diabetic patients NEPHROLOGY, DIALYSIS, TRANSPLANTATION 21: 2159-2165. 2006

González-Sánchez JL, Martínez-Calatrava MJ, Martínez-Larrad MT, Zabena C, Fernández-Pérez C, Laakso M, Serrano-Ríos M, Laakso M. 2006. Interaction of the - 308G/A promoter polymorphism of the tumor necrosis factor-alfa gene with single-nucleotide polymorphism 45 of the adiponectin gene: effect on serum adiponectin concentrations in a Spanish population CLINICAL CHEMISTRY 52: 97-103. 2006

Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. 2006. Proteinuria and metabolic syndrome as predictors of cardiovascular death in non-diabetic and type 2 diabetic men and women DIABETOLOGIA 49: 56-65. 2006

Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma V-M, Naukkarinen A, Laakso M, Laakso M. 2006. HLA genotyping is useful in the evaluation of the risk for coelic disease in the 1st-degree relatives of patients with coeliac disease. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 41: 1299-1304. 2006

Hammarstedt A, Pihlajamäki J, Sopasakis VR, Gogg S, Jansson P-A, Laakso M, Smith U. 2006. Visfatin is an adipokine, but it is not regulated by Thiazolidinediones. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 91: 1181-1184. 2006

Keech A, Simes J, Barter P, Best J, Scott R, Taskinen M-R, on behalf of the FIELD Management Committee, Laakso M. 2006. Correction to the FIELD study report. LANCET 368: 1415. 2006

Kärkkäinen S, Reissell E, Heliö T, Kaartinen M, Tuomainen P, Toivonen L, Kuusisto J, Kupari M, Nieminen MS, Laakso M, Peuhkurinen K, Laakso M. 2006. Novel mutations in the lamin A/C gene in heart transplant recipients with end stage dilated cardiomyopathy. HEART 92: 524-526. 2006

Laakso M, Kovanen PT. 2006. Metabolic syndrome: To be or not to be?. Annals of Medicine 38: 32-33. 2006

Laakso M. 2006. Metformiini: vanha lääke, uusi vaikutusmekanismi. DUODECIM 122: 1563-1564. 2006

Laakso M. 2006. Mutations in the PPARgamma gene relevant for diabetes and the metabolic syndrome: Brigelius-Flohé R, Joost H-G, Nutritional Genomics. Impact on Health and Disease.Wiley. 195-207. 2006

Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliot P, Geny B, Laakso M, Puigserver P, Auwerx J, Laakso M. 2006. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. CELL 127: 1109-1122. 2006

Koivisto AM, Helisalmi S, Pihlajamäki J, Hiltunen M, Koivisto K, Moilanen L, Kuusisto J, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso M, Soininen H, Koivisto AM, Helisalmi S, Hiltunen M, Soininen H, Laakso M. 2006. Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzhimer¿s disease in the Finnish population. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 22: 449-453. 2006

Lumiaho A, Laakso M. 2006. Autosomissa vallitsevasti periytyvä munuaisten monirakkulatauti. DUODECIM 122: 200-207. 2006

Salopuro T, Pulkkinen L, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M, for the Finnish Diabetes Prevention Study Group, Salopuro T, Pulkkinen L, Uusitupa M, Laakso M. 2005. Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: The Finnish diabetes prevention study. INTERNATIONAL JOURNAL OF OBESITY 29: 1245-1251. 2005

Saraheimo M, Forsblom C, Hansen TK, Teppo A-M, Fagerudd J, Pettersson-Fernholm K, Thiel S, Tarnow L, Ebeling P, Flyvbjerg A, Groop P-H, on behalf of the FinnDiane Study Group, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Mykkänen L, Karhapää P. 2005. Increased levels of mannan-binding lectin in type 1 diabetic patients with incipient and overt nephropathy. DIABETOLOGIA 48: 198-202. 2005

Saraheimo M, Forsblom C, Fagerudd J, Teppo A-M, Pettersson-Fernholm K, Frystyk J, Flyvbjerg A, Groop P-H, on behalf of the FinnDiane Study Group, Laakso M, Niskanen L, Vauhkonen I, Voutilainen E, Mykkänen L, Karhapää P, Huttunen E. 2005. Serum adiponectin in increased in type 1 diabetic patients with nephropathy. DIABETES CARE 28: 1410-1414. 2005

Roden M, Laakso M, Johns D, Widel M, Urquhart R, Richardson C, Mariz S, Tan MH. 2005. Long-term effects of pioglitazone and metformin on insulin sensitivity in patients with type 2 diabetes mellitus. DIABETIC MEDICINE 22: 1101-1106. 2005

Salmenniemi U, Zacharova J, Ruotsalainen E, Vauhkonen I, Pihlajamäki J, Kainulainen S, Punnonen K, Laakso M, Laakso M. 2005. Association of adiponectin level and variants in the adiponectin gene with glucose metabolism, energy expenditure, and cytokines in offspring of type 2 diabetic patients. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 90: 4216-4223. 2005

Salmenniemi U, Ruotsalainen E, Vänttinen M, Vauhkonen I, Pihlajamäki J, Kainulainen S, Punnonen K, Laakso M. 2005. High amount of visceral fat mass is associated with multiple metabolic changes in offspring of type 2 diabetic patients. INTERNATIONAL JOURNAL OF OBESITY 29: 1464-1470. 2005

Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M. 2005. Tumour necrosis factor-alpha gene haplotype is associated with pre-eclampsia. MOLECULAR HUMAN REPRODUCTION 11 6: 437-440. 2005

The Field study investigators, Laakso M, Jantunen A, Kähkönen H, Kortelainen S, Koukkunen H, Laitinen M, Lehto S, Lehto R, Lumiaho A. 2005. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial LANCET 366: 1849-1861. 2005

Sipola P, Lauerma K, Jääskeläinen P, Laakso M, Peuhkurinen K, Manninen H, Aronen HJ, Kuusisto J, Laakso M. 2005. Cine MR imaging of myocardial contractile impairment in patients with hypertrophic cardiomyopathy attributable to Asp175Asn mutation in the alpha-tropomyosin gene. RADIOLOGY 236: 815- 824. 2005

Zacharova J, Todorova BR, Chiasson J-L, Laakso M, for the STOP-NIDDM Study Group, Laakso M. 2005. The G-250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial JOURNAL OF INTERNAL MEDICINE 257: 185-193. 2005

The FIELD Study Investigators, Laakso M, Kortelainen S, Koukkunen H, Lehto S, Lehto R, Lumiaho A, Ruotsalainen S. 2005. Fenofibrate intervention and event lowering in diabetes (FIELD) study: baseline characteristics and short-term effects of fenofibrate [ISRCTN64783481]. CARDIOVASCULAR DIABETOLOGY [ONLINE: HTTP://WWW.CARDIAB.COM/] 4: article 13 [9 p.]. 2005

Thron LM, Forsblom C, Fagerudd J, Thomas MC, Pettersson-Fernholm K, Saraheimo M, Wadén J, Rönnback M, Rosengård-Bärlund M, af Björkesten C-G, Taskinen M-R, Groop P-H, on behalf of the FinnDiane Study Group, Laakso M, Niskanen L, Mykkänen L. 2005. Metabolic syndrome in type 1 diabetes: association with diabetic nephropathy and glycemic control (the FinnDiane study) DIABETES CARE 28: 2019-2024. 2005

Vauhkonen I, Niskanen L, Knip M, Moilanen Mykkänen L, Uusitupa M, Laakso M. 2005. Subtle hyperproinsulinaemia characterises the defective insulin secretory capacity in offspring of glutamic acid decarboxylase antibody-positive patients with latent autoimmune diabetes mellitus in adults. EUROPEAN JOURNAL OF ENDOCRINOLOGY 153: 265-273. 2005

Vänttinen M, Nuutila P, Kuulasmaa T, Pihlajamäki J, Hällsten K, Virtanen KA, Lautamäki R, Peltoniemi P, Takala T, Viljanen APM, Knuuti J, Laakso M, Laakso M. 2005. Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake. DIABETES (NY) 54: 3587-3591. 2005

Vänttinen M, Nuutila P, Pihlajamäki J, Hällsten K, Virtanen KA, Lautamäki R, Peltoniemi P, Kemppainen J, Takala T, Viljanen APM, Knuuti J, Laakso M, Laakso M. 2005. The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-gamma2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 90: 4249-4254. 2005

Yang X, Jansson P-A, Pellmé F, Laakso M, Smith U, Laakso M. 2005. Effect of the interleukin-6 (-174) G/C promoter polymorphism on adiponectin and insulin sensitivity. OBESITY (SILVER SPRING, MD.) 13: 813-817. 2005

Zacharova J, Chiasson J-L, Laakso M, for the STOP-NIDDM Study Group, Laakso M. 2005. Leptin receptor gene variation predicts weight change in subjects with impaired glucose tolerance. OBESITY (SILVER SPRING, MD.) 13: 501-506. 2005

Zacharova J, Chiasson J-L, Laakso M, for the STOP-NIDDM Study Group, Laakso M. 2005. The common polymorphisms (single nucleotide polymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: The STOPP-NIDDM trial. DIABETES (NY) 54: 893-899. 2005

Pihlajamäki J, Kinnunen M, Ruotsalainen E, Salmenniemi U, Vauhkonen I, Kuulasmaa T, Kainulainen S, Laakso M, Laakso M. 2005. Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offpring of patients with type 2 diabetes. DIABETOLOGIA 48: 1331-1334. 2005

Pätäri A, Karhapää P, Taipale H, Salmenniemi U, Ruotsalainen E, Vanninen P, Holthöfer H, Laakso M. 2005. A 100-kDa urinary protein is associated with insulin resistance in offspring of type 2 diabetic patients. DIABETOLOGIA 48: 1844-1850. 2005

Laukkanen O, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, Laakso M. 2005. Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversation from impaired glucose tolerance to type 2 diabetes.The Finnish diabetes prevention study. DIABETES (NY) 54: 2256-2260. 2005

Peltola P, Lumiaho A, Miettinen R, Pihlajamäki J, Sandford R, Laakso M, Laakso M. 2005. Genetics and phenotypic characteristics of autosomal dominant polycystic kidney disease in Finns. JOURNAL OF MOLECULAR MEDICINE 83: 638-646. 2005

Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. 2005. Type 2 diabetes as a "coronary heart diasease equivalent". An 18-year prospective population-based study in Finnish subjects. DIABETES CARE 28: 2901-2907. 2005

Pedersen TR, Faergeman O, Kastelein JJP, Olsson AG, Tikkanen MJ, Holme I, Lytken Larsen M, Bendiksen FS, Lindahl C, Szarek M, Tsai J, for the IDEAL Study Group, Laakso M, Lehto S, Gylling H. 2005. High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction. The IDEAL study: A randomized controlled trial. JAMA - JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 294: 2437-2445. 2005

Dahlman I, Kaaman M, Jiao H, Kere J, Laakso M, Arner P, Laakso M. 2005. The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects DIABETES (NY) 54: 3032-3034. 2005

Esapa C, Moffitt JH, Novials A, McNamara CM, Levy JC, Laakso M, Gomis R, Clark A. 2005. Islet amyloid polypeptide gene promoter polymorphisms are not associated with type 2 diabetes or with the severity of islet amyloidosis. BIOCHIMICA ET BIOPHYSICA ACTA 1740: 74-78. 2005

Fröjdö S, Sjölind L, Parkkonen M, Mäkinen V-P, Kilpikari R, Pettersson-Fernholm K, Forsblom C, Fagerudd J, Tikellis C, Cooper ME, Wessman M, Groop P-H, FinnDiane Study Group. 2005. Polymorphisms in the gene encoding angiotensin I converting enzyme 2 and diabetic nephropathy. DIABETOLOGIA 48: 2278-2281. 2005

Fueger PT, Shearer J, Krueger TM, Posey KA, Bracy DP, Heikkinen S, Laakso M, Rottman JN, Wasserman DH. 2005. Hexokinase II protein content is a determinant of exercise endurance capacity in the mouse. JOURNAL OF PHYSIOLOGY (CAMBRIDGE) 566 2: 533-541. 2005

González-Sánchez JL, Zabena CA, Martínez-Larrad MT, Fernández-Pérez C, Pérez-Barba M, Laakso M, Serrano-Ríos M, Laakso M. 2005. An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance OBESITY (SILVER SPRING, MD.) 13: 807-812. 2005

Heinonen S, Korhonen S, Helisalmi S, Koivunen R, Tapanainen J, Hippeläinen M, Laakso M. 2005. Associations between two single nucleotide polymorphism in the adiponectin gene and polycystic ovary syndrome. GYNECOLOGICAL ENDOCRINOLOGY 21 3: 165-169. 2005

Huopio H, Laakso M, Otonkoski T. 2005. Synnynnäinen hyperinsulinismi. DUODECIM 121: 1166-1175. 2005

Dormandy JA, Charbonnel B, Eckland DJA, Erdmann E, Massi-Benedetti M, Moules IK, Skene AM, Tan MH, Lefèbvre PJ, Murray GD, Standl E, Wilcox RG, Wilhelmsen L, Betteridge J, Birkeland K, Golay A, Heine RJ, Korányi L, Laakso M, Mokán M, Norkus A, Pirags V, Podar T, Scheen A, Scherbaum W, Schernthaner G, Schmitz O, Skrha J, Smith U, Taton J, on behalf of the PROactive investigators. 2005. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial LANCET 366: 1279-1289. 2005

Kilhovd BK, Juutilainen A, Lehto S, Rönnemaa T, Torjesen PA, Birkeland KI, Berg TJ, Hanssen KF, Laakso M. 2005. High serum levels of advanced glycation end products predict increased coronary heart disease mortality in nondiabetic women but not in nondiabetic men. A population-based 18-year follow-up study. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 25: 815-820. 2005

Laakso M, Kuusisto J. 2005. Insulin resistance and coronary heart disease: Serrano Ríos M, Caro JF, Carraro R, Gutiérrez Fuentes JA, The Metabolic Syndrome at the Beginning of the XXIst Century.Elsevier. 369-382. 2005

Laakso M. 2005. Metabolisen oireyhtymän uudet kriteerit ja hoito. DUODECIM 121: 1521-1530. 2005

Laakso M. 2005. Prevention of type 2 diabetes. CURRENT MOLECULAR MEDICINE 5: 365-374. 2005

Boden G, Laakso M. 2005. Lipids and glucose in type 2 diabetes: what about the beta-cell and the mitochondria? Response to Eldor and Raz. DIABETES CARE 28: 986-987. 2005

Lehto M, Snapinn S, Dickstein K, Swedberg K, Nieminen M, on behalf of the OPTIMAAL investigators, Laakso M, Lehto S. 2005. Prognostic risk of atrial fibrillation in acute myocardial infarction complicated by left ventricular dysfunction: the OPTIMAAL experience. EUROPEAN HEART JOURNAL 26: 350-356. 2005

Luoma JS, Kareinen A, Närvänen O, Viitanen L, Laakso M, Ylä-Herttuala S. 2005. Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease FREE RADICAL BIOLOGY & MEDICINE 39: 1660-1665. 2005

Malmberg K, Rydén L, Wedel H, Birkeland K, Bootsma A, Dickstein K, Efendic S, Fisher M, Hamsten A, Herlitz J, Hildebrandt P, MacLeod K, Laakso M, Torp-Pedersen C, Waldenström A, for the DIGAMI 2 Investigators. 2005. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI ): effects on mortality and morbidity. EUROPEAN HEART JOURNAL 26: 650-661. 2005

Mousavinasab F, Tähtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Keinänen-Kiukaanniemi S, Laakso M, Laakso M. 2005. Effect of the Pro12Ala polymorphism of the PPARgamma2 gene on serum adiponectin changes. ENDOCRINE 27: 307-309. 2005

Mousavinasab F, Tähtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Keinänen-Kiukaanniemi S, Laakso M, Laakso M. 2005. Common polymorphisms in the PPARgamma2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men. MOLECULAR GENETICS AND METABOLISM (ARLANDO) 84: 344-348. 2005

Salmenniemi U, Ruotsalainen E, Pihlajamäki J, Vauhkonen I, Kainulainen S, Punnonen K, Vanninen E, Laakso M. 2004. Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome. CIRCULATION 110: 3842-3848. 2004

Pihlajamäki J, Vanhala M, Vanhala P, Laakso M, Laakso M. 2004. The Pro12Ala polymorphism of the PPARgamma2 gene regulates weight from birth to adulthood. OBESITY (SILVER SPRING, MD.) 12 2: 187-190. 2004

Rutanen J, Pihlajamäki J, Karhapää P, Vauhkonen I, Kuusisto J, Moilanen Mykkänen L, Laakso M, Laakso M. 2004. The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain OBESITY (SILVER SPRING, MD.) 12: 1060-1066. 2004

Rioux JD, Karinen H, Kocher K, McMahon SG, Kärkkäinen P, Janatuinen E, Heikkinen M, Julkunen R, Pihlajamäki J, Naukkarinen A, Kosma V-M, Daly MJ, Lander ES, Laakso M, Laakso M. 2004. Genomewide search and association studies in a Finnish celiac disease population: identification of a novel locus and replication of HLA and CTLA4 loci AMERICAN JOURNAL OF MEDICAL GENETICS. PART A 130: 345-350. 2004

Pirinen E, Heikkinen S, Malkki M, Deep SS, Jänne J, Laakso M. 2004. Analysis of the human hexokinase II promoter in vivo: lack of insulin response within 4.0 kb. BIOCHIMICA ET BIOPHYSICA ACTA - GENE STRUCTURE AND EXPRESSION 1676: 149-154. 2004

Siitonen N, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M. 2004. Association between a deletion/insertion polymorphism in the alfa2B-adrenergic receptor gene and insulin secretion and type 2 diabetes. The Finnish diabetes prevention study DIABETOLOGIA 47: 1416-1424. 2004

Salopuro T, Lindström J, Eriksson JG, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M, Finnish Diabetes Preventio Study Group. 2004. Common variants in beta2- and beta3-adrenergic receptor

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