Marko Pietilä

Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions

Hyvönen, Mervi T.; Smirnova, Olga A.; Mitkevich, Vladimir A.; Tunitskaya, Vera L.; Khomutov, Maxim; Karpov, Dmitry S.; Korolev, Sergey P.; Häkkinen, Merja R.; Pietilä, Marko; Gottikh, Marina B.; Vepsäläinen, Jouko; Alhonen, Leena; Makarov, Alexander A.; Kochetkov, Sergey N.; Wallace, Heather M.; Keinänen, Tuomo A.; Khomutov, Alex R.. 2022. International journal of molecular sciences. 23: A1 Journal article (refereed), original research

Barriers and Facilitators to Cervical Screening among Migrant Women of African Origin: A Qualitative Study in Finland

Idehen, Esther E; Pietilä, Anna-Maija; Kangasniemi, Mari. 2020. International journal of environmental research and public health. 17: 7473 A1 Journal article (refereed), original research

Erillisistä molekyylibiologian harjoitustyökursseista tutkimusprojektiksi

Pietilä Marko, Halmekytö Maria. 2015. Yliopistopedagogiikka. 22: 32-35 D1 Article in a trade journal

Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A

Hyvönen Mervi T, Koponen Taina, Weisell Janne, Pietilä Marko, Khomutov Alex R, Vepsäläinen Jouko, Alhonen Leena, Keinänen Tuomo A. 2013. Biochemical journal. 453: 467-474 A1 Journal article (refereed), original research

Systemic overexpression of antizyme 1 in mouse reduces ornithine decarboxylase activity without major changes in tissue polyamine homeostasis

Pietilä M, Dhungana H, Uimari A, Sironen R, Alhonen L. 2013. Transgenic research. [Epub ahead of print]: - A1 Journal article (refereed), original research

Terveyden biotieteiden opiskelijoiden työelämäorientaation rakentaminen

Pietilä M, Ryhänen S, Mahonen A, Palvimo J. Teoksessa: Kaarniemi H(toim.) , 2013. Luotsausta ja luovintaa. s. 63-70. B2 Book section

Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults

Cerrada-Gimenez M, Pietilä Marko, Loimas Suvikki, Pirinen Eija , Hyvönen Mervi T, Keinänen Tuomo A, Jänne Juhani, Alhonen Leena. 2011. Transgenic research. 20: 387-396 A1 Journal article (refereed), original research

Inducible expression of antizyme 1 in prostate cancer cell lines after lentivirus mediated gene transfer

Pietilä M, Lampinen A, Pellinen R, Alhonen L. 2011. Amino acids. 2012 Feb;42(2-3): 559-64 A1 Journal article (refereed), original research

Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions

Ramot Y, Tiede S, Bíró T, Abu Bakar MH, Sugawara K, Philpott MP, Harrison W, Pietilä M, Paus R.. 2011. PLoS ONE. : -- A1 Journal article (refereed), original research

Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis

Pirinen E, Gylling H, Itkonen P, Yaluri N, Heikkinen S, Pietilä M, Kuulasmaa T, Tusa M, Cerrada-Gimenez M, Pihlajamäki J, Alhonen L, Jänne J, Miettinen TA & Laakso M. 2010. Amino acids. 38: 549-560 A1 Journal article (refereed), original research

Cutaneous application of alpha-methylspermidine activates the growth of resting hair follicles in mice

Fashe TM, Keinänen TA, Grigorenko NA, Khomutov AR, Jänne J, Alhonen L & Pietilä M. 2010. Amino acids. 38: 583-590 A1 Journal article (refereed), original research

Polyamines and hair: a couple in search of perfection

Ramot Y, Pietilä M, Giuliani G, Rinaldi F, Alhonen L & Paus R. 2010. Experimental dermatology. 19: 784-790 A1 Journal article (refereed), original research

Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes

Vuohelainen S, Pirinen E, Cerrada-Gimenez M, Keinänen TA, Uimari A, Pietilä M, Khomutov AR, Jänne J & Alhonen L. 2010. Journal of cellular and molecular medicine. 14: 1683-1692 A1 Journal article (refereed), original research

Synthesis and Biological Characterization of Novel Charge-Deficient Spermine Analogues

Weisell J, Hyvönen MT, Häkkinen MR, Grigorenko NA, Pietilä M, Lampinen A, Kochetkov SN, Alhonen L, Vepsäläinen J, Keinänen TA et al. 2010. Journal of medicinal chemistry. 53: 5738-5748 A1 Journal article (refereed), original research

Methylated analogs of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism

Khomutov AR, Keinanen TA, Grigorenko NA, Hyvonen MT, Uimari A, Pietila M, Cerrada-Gimenez M, Simonian AR, Khomutov MA, Vepsalainen J, Alhonen L, Janne J. 2009. MOLEKULIARNAIA BIOLOGIIA [MOSKVA]. 43: 274-285 A1 Journal article (refereed), original research

Transgenic animals modelling polyamine metabolism-related diseases

Alhonen L, Uimari A, Pietilä M, Hyvönen MT, Pirinen E, Keinänen TA. 2009. Essays in biochemistry. 46: 125-144 A1 Journal article (refereed), original research

Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism

Pirinen E, Kuulasmaa T, Pietilä M, Heikkinen S, Tusa M, Itkonen P, Boman S, Skommer J, Virkamäki A, Hohtola E, Kettunen M, Fatrai S, Kansanen E, Koota S, Niiranen K, Parkkinen J, Levonen A-L, Ylä-Herttuala S, Hiltunen JK, Alhonen L, Smith U, Jänne J. 2007. Molecular and cellular biology. 27: 4953-4967 A1 Journal article (refereed), original research

Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis

Merentie M, Uimari A, Pietilä M, Sinervirta R, Keinänen TA, Vepsäläinen J, Khomutov A, Grigorenko N, Herzig K-H, Jänne J, Alhonen L. 2007. Amino acids. 33: 323-330 A1 Journal article (refereed), original research

Genetic engineering of polyamine catabolism in transgenic mice and rats

Jänne J, Alhonen L, Pietilä M, Keinänen TA, Suppola S, Pirinen E, Hyvönen MT, Järvinen A, Laakso M. Teoksessa: Wang J-Y, Casero RA Jr(toim.) , 2006. Polyamine Cell Signaling. Physiology, Pharmacology, and Cancer Research. s. 465-477. Humana Press A3 Book section, Chapters in research books

Genetic manipulation of polyamine catabolism in rodents

Jänne J, Alhonen L, Pietilä M, Keinänen TA, Uimari A, Hyvönen MT, Pirinen E. 2006. Journal of biochemistry. 139: 155-160 A1 Journal article (refereed), original research

Mice with targeted disruption of spermidine/spermine N1-acetyltransferese gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging

Niiranen K, Keinänen TA, Pirinen E, Heikkinen S, Tusa M, Fatrai S, Suppola S, Pietilä M, Uimari A, Laakso M, Alhonen L, Jänne J. 2006. Journal of cellular and molecular medicine. 10: 933-945 A1 Journal article (refereed), original research

Polyamiinien merkitys keratinosyyttien erilaistumisessa

Pietilä M. 2006. Solubiologi. 24: 23-27 D1 Article in a trade journal

Animal disease models generated by genetic engineering of polyamine metabolism

Jänne J, Alhonen L, Keinänen TA, Pietilä M, Uimari A, Pirinen E, Hyvönen MT, Järvinen A. 2005. Journal of cellular and molecular medicine. 9: 865-882 A1 Journal article (refereed), original research

Disturbed keratinocyte differentiation in transgenic mice and organotypic keratinocyte cultures as a result of spermidine/spermine N1-acetyltransferase overexpression

Pietilä M, Pirinen E, Keskitalo S, Juutinen S, Pasonen-Seppänen S, Keinänen T, Alhonen L, Jänne J. 2005. Journal of investigative dermatology. 124: 596-601 A1 Journal article (refereed), original research

Genetic approaches to the cellular functions of polyamines in mammals

Jänne J, Alhonen L, Pietilä M, Keinänen TA. 2004. Febs journal. 271: 877-894 A2 Review article, Literature review, Systematic review

Polyamines are required for the initiation of rat liver regeneration

Alhonen L, Räsänen T-L, Sinervirta R, Parkkinen JJ, Korhonen V-P, Pietilä M, Jänne J. 2002. Biochemical journal. 362: 149-153 A1 Journal article (refereed), original research

Targeted disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells

Niiranen K, Pietilä M, Pirttilä TJ, Järvinen A, Halmekytö M, Korhonen V-P, Keinänen TA, Alhonen L, Jänne J. 2002. Journal of biological chemistry. 277: 25323-25328 A1 Journal article (refereed), original research

Activation of Polyamine Catabolism in Transgenic Mice

Pietilä M. 2001. Kuopion yliopiston julkaisuja C. Luonnontieteet ja ympäristötieteet G5 Doctoral dissertation (article)

Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N1-acetyltransferase

Pietilä M, Parkkinen JJ, Alhonen L, Jänne J. 2001. Journal of investigative dermatology. 116: 801-805 A1 Journal article (refereed), original research

Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs

Korhonen V-P, Niiranen K, Halmekytö M, Pietilä M, Diegelman P, Parkkinen JJ, Eloranta T, Porter CW, Alhonen L, Jänne J. 2001. Molecular pharmacology. 59: 231-238 A1 Journal article (refereed), original research

Genetic engineering of polyamine metabolism: consequences of the activation of polyamine biosynthesis or catabolism in transgenic rodents

Jänne J, Alhonen L, Halmekytö M, Pietilä M. Teoksessa: Bardócz S, White A(toim.) , 1999. Polyamines in Health and Nutrition. s. 87-98. Kluwer A3 Book section, Chapters in research books

Hexokinase II-deficient mice: prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes

Heikkinen S, Pietilä M, Halmekytö M, Suppola S, Pirinen E, Deeb SS, Jänne J, Laakso M. 1999. Journal of biological chemistry. 274: 22517-22523 A1 Journal article (refereed), original research

Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a poly

Suppola S, Pietilä M, Parkkinen JJ, Korhonen V-P, Alhonen L, Halmekytö M, Porter CW, Jänne J. 1999. Biochemical journal. 338: 311-316 A1 Journal article (refereed), original research

Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N1-acetyltransferase show enhanced sensitivity to the polyamine analog, N1, N11-diethylnorspermine

Alhonen L, Pietilä M, Halmekytö M, Kramer DL, Jänne J, Porter CW. 1999. Molecular pharmacology. 54: 693-698 A1 Journal article (refereed), original research

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Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions

Barriers and Facilitators to Cervical Screening among Migrant Women of African Origin: A Qualitative Study in Finland

Erillisistä molekyylibiologian harjoitustyökursseista tutkimusprojektiksi

Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A

Systemic overexpression of antizyme 1 in mouse reduces ornithine decarboxylase activity without major changes in tissue polyamine homeostasis

Terveyden biotieteiden opiskelijoiden työelämäorientaation rakentaminen

Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults

Inducible expression of antizyme 1 in prostate cancer cell lines after lentivirus mediated gene transfer

Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions

Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis

Cutaneous application of alpha-methylspermidine activates the growth of resting hair follicles in mice

Polyamines and hair: a couple in search of perfection

Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes

Synthesis and Biological Characterization of Novel Charge-Deficient Spermine Analogues

Methylated analogs of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism

Transgenic animals modelling polyamine metabolism-related diseases

Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism

Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis

Genetic engineering of polyamine catabolism in transgenic mice and rats

Genetic manipulation of polyamine catabolism in rodents

Mice with targeted disruption of spermidine/spermine N1-acetyltransferese gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging

Polyamiinien merkitys keratinosyyttien erilaistumisessa

Animal disease models generated by genetic engineering of polyamine metabolism

Disturbed keratinocyte differentiation in transgenic mice and organotypic keratinocyte cultures as a result of spermidine/spermine N1-acetyltransferase overexpression

Genetic approaches to the cellular functions of polyamines in mammals

Polyamines are required for the initiation of rat liver regeneration

Targeted disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells

Activation of Polyamine Catabolism in Transgenic Mice

Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N1-acetyltransferase

Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs

Genetic engineering of polyamine metabolism: consequences of the activation of polyamine biosynthesis or catabolism in transgenic rodents

Hexokinase II-deficient mice: prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes

Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a poly

Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N1-acetyltransferase show enhanced sensitivity to the polyamine analog, N1, N11-diethylnorspermine