MIKA REINISALO

Contact info

Keywords

Research groups - UEF

• 
  Kaarniranta AMD Lab
• 
  Ocular Drug Delivery group (ODD)

Publications

• del Amo, Eva M.; Hammid, Anam; Tausch, Melanie; Toropainen, Elisa; Sadeghi, Amir; Valtari, Annika; Puranen, Jooseppi; Reinisalo, Mika; Ruponen, Marika; Urtti, Arto; Sauer, Achim; Honkakoski, Paavo. 2022. Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations International journal of pharmaceutics 613: 121361. 2022
• Toropainen, Elisa; Fraser-Miller, Sara J; Novakovic, Dunja; Del Amo, Eva M; Vellonen, Kati-Sisko; Ruponen, Marika; Viitala, Tapani; Korhonen, Ossi; Auriola, Seppo; Hellinen, Laura; Reinisalo, Mika; Tengvall, Unni; Choi, Stephanie; Absar, Mohammad; Strachan, Clare; Urtti, Arto. 2021. Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin Pharmaceutics 13 4: 452. 2021
• Fayyaz, Anam; Vellonen, Kati-Sisko; Ranta, Veli-Pekka; Toropainen, Elisa; Reinisalo, Mika; Valtari, Annika; Puranen, Jooseppi; D'Amico Ricci, Giuseppe; Heikkinen, Emma M.; Gardner, Iain; Ruponen, Marika; Urtti, Arto; Jamei, Masoud; del Amo, Eva M. 2021. Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye European journal of pharmaceutics and biopharmaceutics 166: 155-162. 2021
• Hellinen, Laura; Bahrpeyma, Sina; Rimpelä, Anna-Kaisa; Hagström, Marja; Reinisalo, Mika; Urtti, Arto. 2020. Microscale Thermophoresis as a Screening Tool to Predict Melanin Binding of Drugs Pharmaceutics 12 6: 554. 2020
• Hellinen, Laura; Sato, Kazuki; Reinisalo, Mika; Kidron, Heidi; Rilla, Kirsi; Tachikawa, Masanori; Uchida, Yasuo; Terasaki, Tetsuya; Urtti, Arto. 2019. Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters Investigative ophthalmology and visual science 60 15: 5022-5034. 2019
• Touloupi, K; Kublbeck, J; Magklara, A; Molnar, F; Reinisalo, M; Konstandi, M; Honkakoski, P; Pappas, P. 2019. The basis for strain-dependent rat aldehyde dehydrogenase 1A7 (ALDH1A7) gene expression Molecular pharmacology 96 5: 655-663. 2019
• Subia, B; Reinisalo, M; Dey, N; Tavakoli, S; Subrizi, A; Ganguli, M; Ruponen, M. 2019. Nucleic acid delivery to differentiated retinal pigment epithelial cells using cell-penetrating peptide as a carrier European journal of pharmaceutics and biopharmaceutics 140: 91-99. 2019
• Hellinen, L; Pirskanen, L; Tengvall-Unadike, U; Urtti, A; Reinisalo, M. 2019. Retinal Pigment Epithelial Cell Line with Fast Differentiation and Improved Barrier Properties Pharmaceutics 11 8: 412. 2019
• Hellinen, L; Hagström, M; Knuutila, H; Ruponen, M; Urtti, A; Reinisalo, M. 2019. Characterization of artificially re-pigmented ARPE-19 retinal pigment epithelial cell model Scientific reports 9 1: 13761. 2019
• Fayyaz, A; Ranta, VP; Toropainen, E; Vellonen, KS; Ricci, GD; Reinisalo, M; Heikkinen, EM; Gardner, I; Urtti, A; Jamei, M; del Amo, EM. 2019. Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits Molecular pharmaceutics 12 4: e007045. 2019
• Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration Redox biology 2019; 20: 1-12. 2018
• Rimpelä, Anna-Kaisa; Reinisalo, Mika; Hellinen, Laura; Grazhdankin, Evgeni; Kidron, Heidi; Urtti Arto; del Amo, Eva M. 2018. Implications of melanin binding in ocular drug delivery ADVANCED DRUG DELIVERY REVIEWS 126: 23-43. 2018
• del Amo Eva M, Rimpelä Anna-Kaisa, Heikkinen Emma, Kari Otto K, Ramsay Eva, Lajunen Tatu, Schmitt Mechthild, Pelkonen Laura, Bhattacharya Madhushree, Richardson Dominique, Subrizi Astrid, Turunen Tiina, Reinisalo Mika, Itkonen Jaakko, Toropainen Elisa, Casteleijn Marco, Kidron Heidi, Antopolsky Maxim, Vellonen Kati-Sisko, Ruponen Marika, et al.. 2017. Pharmacokinetic aspects of retinal drug delivery PROGRESS IN RETINAL AND EYE RESEARCH 57: 134-185. 2017
• Juuti-Uusitalo K, Koskela A, Kivinen N, Viiri J, Hyttinen JMT, Reinisalo M, Koistinen A, Uusitalo H, Sinha D, Skottman H, Kaarniranta K. 2017. Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18 5: 1089. 2017
• Pelkonen L, Sato K, Reinisalo M, Kidron H, Tachikawa M, Watanabe M, Uchida Y, Urtti A, Terasaki T. 2017. LC-MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line. Molecular Pharmaceutics 14 3: 605-613. 2017
• Pelkonen L, Tengvall-Unadike U, Ruponen M, Kidron H, del Amo EM, Reinisalo M, Urtti A. 2017. Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 109: 162-168. 2017
• Pelkonen Laura, Reinisalo Mika, Morin-Picardat Emmanuelle, Kidron Heidi, Urtti Arto. 2016. Isolation of Intact and Functional Melanosomes from the Retinal Pigment Epithelium. PLOS ONE 11 8: e0160352. 2016
• Koskela Ali, Reinisalo Mika, Petrovski Goran, Sinha Debasish, Olmiere Céline, Karjalainen Reijo, Kaarniranta Kai. 2016. Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells. Nutrients 8 5: 284. 2016
• Hakkarainen Jenni J, Reinisalo Mika, Ragauskas Symantas, Seppänen Aila, Kaja Simon, Kalesnykas Giedrius. 2016. Acute cytotoxic effects of marketed ophthalmic formulations on human corneal epithelial cells. INTERNATIONAL JOURNAL OF PHARMACEUTICS 511 1: 73-78. 2016
• Reinisalo Mika, Kårlund Anna, Koskela Ali, Kaaniranta Kai, Karjalainen Reijo O.. 2015. Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases. Oxidative Medicine and Cellular Longevity 2015, Article ID 340520: 24 p.. 2015
• Koskela Ali, Reinisalo Mika, Hyttinen Juha MT, Kaarniranta Kai, Karjalainen Reijo O. 2014. Pinosylvin-mediated protection against oxidative stress in human retinal pigment epithelial cells. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 20: 760-769. 2014
• Reinisalo Mika, Putula Jaana, Mannermaa Eliisa, Urtti Arto, Honkakoski Paavo. 2012. Regulation of the human tyrosinase gene in retinal pigment epithelium cells: the significance of transcription factor orthodenticle homeobox 2 and its polymorphic binding site MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 18: 38-54. 2012
• Reinisalo Mika. 2012. Studies on Retina-specific Gene Expression. Publications of the University of Eastern Finland. Dissertations in Health Sciences 119. 2012
• Kauppinen Ari, Reinisalo Mika, Pellinen Riikka, Korhonen Ossi, Järvinen Kristiina, Ketolainen Jarkko. 2010. Effect of freeze-drying conditions on transfection efficiency of cationic polymer DNA complexes. In: (ed.) , The XXI Symposium of the Finnish Society of Physical Pharmacy. ss. 50. 2010
• Küblbeck J, Reinisalo M, Mustonen R & Honkakoski P. 2010. Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 40: 263-272. 2010
• Mannermaa E, Reinisalo M, Ranta V-P, Vellonen K-S, Kokki H, Saarikko A, Kaarniranta K & Urtti A. 2010. Filter-cultured ARPE-19 cells as outer blood-retinal barrier model. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 40: 289-296. 2010
• Kauppinen Ari, Reinisalo Mika, Pellinen Riikka, Gieseler Henning, Schneid Stefan, Rutzinger Susanne, Beirowski Jakob, Korhonen Ossi, Järvinen Kristiina, Ketolainen Jarkko. 2009. Determining the critical properties of formulations for freeze drying by DSC and FDM, 4th FinPharmaNet. 1. 2009
• Ruponen M, Arkko S, Urtti A, Reinisalo M, Ranta V-P. 2009. Intracellular DNA release and elimination correlate poorly with transgene expression after non-viral transfection. JOURNAL OF CONTROLLED RELEASE 136: 226-231. 2009
• Huuskonen P, Storvik M, Reinisalo M, Honkakoski P, Rysä J, Hakkola J, Pasanen M. 2008. Microarray analysis of the global alterations in the gene expression in the placentas from cigarette-smoking mothers. CLINICAL PHARMACOLOGY AND THERAPEUTICS 83: 542-550. 2008
• Männistö M, Reinisalo M, Ruponen M, Honkakoski P, Tammi M, Urtti A. 2007. Polyplex-mediated gene transfer and cell cycle: effect of carrier on cellular uptake and intracellular kinetics, and significance of glycosaminoglycans. JOURNAL OF GENE MEDICINE 9: 479-487. 2007
• Reinisalo M, Urtti A, Honkakoski P. 2006. Freeze-drying of cationic polymer DNA complexes enables their long-term storage and reverse transfection of post-mitotic cells JOURNAL OF CONTROLLED RELEASE 110: 437-443. 2006
• Korjamo T, Honkakoski P, Toppinen M-R, Niva S, Reinisalo M, Palmgrén JJ, Mönkkönen J. 2005. Absorption properties and P-glycoprotein activity of modified Caco-2 cell lines. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 26: 266-279. 2005
• Mannermaa E, Rönkkö S, Ruponen M, Reinisalo M, Urtti A. 2005. Long-lasting secretion of transgene product from differentiated and filter-grown retinal pigment epithelial cells after nonviral gene transfer. CURRENT EYE RESEARCH 30: 345-353. 2005
• Mäkinen J, Reinisalo M, Niemi K, Viitala P, Jyrkkärinne J, Chung H, Pelkonen O, Honkakoski P. 2003. Dual action of oestrogens on the mouse constitutive androstane receptor BIOCHEMICAL JOURNAL 376: 465-472. 2003
• Reinisalo M, Urtti A, Honkakoski P. 2003. Retina-specific gene expression and improved DNA transfection in WERI-Rb1 retinoblastoma cells. BIOCHIMICA ET BIOPHYSICA ACTA - GENE STRUCTURE AND EXPRESSION 1628: 169-176. 2003