Mika Reinisalo

Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues

Hammid, Anam; Fallon, John K; Vellonen, Kati Sisko; Lassila, Toni; Reinisalo, Mika; Urtti, Arto; Gonzalez, Francisco; Tolonen, Ari; Smith, Philip C; Honkakoski, Paavo. 2023. European journal of pharmaceutical sciences. 191: . 106603

Intravitreal CendR peptides target laser-induced choroidal neovascularization sites in mice

Puranen, Jooseppi; Korhonen, Sonja; Haugas, Maarja; Lingasamy, Prakash; Teesalu, Tambet; Subrizi, Astrid; Urtti, Arto; Ruponen, Marika; Reinisalo, Mika. 2023. Journal of controlled release. 360: 810-817

Selective drug delivery to the retinal cells: Biological barriers and avenues

Ramsay, Eva; Lajunen, Tatu; Bhattacharya, Madhushree; Reinisalo, Mika; Rilla, Kirsi; Kidron, Heidi; Terasaki, Tetsuya; Urtti, Arto. 2023. Journal of controlled release. 361: 1-19

Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions

Bhattarai, Niina; Hytti, Maria; Reinisalo, Mika; Kaarniranta, Kai; Mysore, Yashavanthi; Kauppinen, Anu. 2022. Immunologic research. 70: 678-687

Mechanisms of cellular retention of melanin bound drugs: Experiments and computational modeling

Bahrpeyma, Sina; Reinisalo, Mika; Hellinen, Laura; Auriola, Seppo; del Amo, Eva M; Urtti, Arto. 2022. Journal of controlled release. 348: 760-770

Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations

del Amo, Eva M.; Hammid, Anam; Tausch, Melanie; Toropainen, Elisa; Sadeghi, Amir; Valtari, Annika; Puranen, Jooseppi; Reinisalo, Mika; Ruponen, Marika; Urtti, Arto; Sauer, Achim; Honkakoski, Paavo. 2022. International journal of pharmaceutics. 613:

Structural Features Affecting the Interactions and Transportability of LAT1-Targeted Phenylalanine Drug Conjugates

Bahrami, Katayun; Järvinen, Juulia; Laitinen, Tuomo; Reinisalo, Mika; Honkakoski, Paavo; Poso, Antti; Huttunen, Kristiina M.; Rautio, Jarkko. 2022. Molecular pharmaceutics. 2023; 20: 206-218

Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

Toropainen, Elisa; Fraser-Miller, Sara J; Novakovic, Dunja; Del Amo, Eva M; Vellonen, Kati-Sisko; Ruponen, Marika; Viitala, Tapani; Korhonen, Ossi; Auriola, Seppo; Hellinen, Laura; Reinisalo, Mika; Tengvall, Unni; Choi, Stephanie; Absar, Mohammad; Strachan, Clare; Urtti, Arto. 2021. Pharmaceutics. 13: 452

Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye

Fayyaz, Anam; Vellonen, Kati-Sisko; Ranta, Veli-Pekka; Toropainen, Elisa; Reinisalo, Mika; Valtari, Annika; Puranen, Jooseppi; D'Amico Ricci, Giuseppe; Heikkinen, Emma M.; Gardner, Iain; Ruponen, Marika; Urtti, Arto; Jamei, Masoud; del Amo, Eva M. 2021. European journal of pharmaceutics and biopharmaceutics. 166: 155-162

Microscale Thermophoresis as a Screening Tool to Predict Melanin Binding of Drugs

Hellinen, Laura; Bahrpeyma, Sina; Rimpelä, Anna-Kaisa; Hagström, Marja; Reinisalo, Mika; Urtti, Arto. 2020. Pharmaceutics. 12: 554

Characterization of artificially re-pigmented ARPE-19 retinal pigment epithelial cell model

Hellinen, L; Hagström, M; Knuutila, H; Ruponen, M; Urtti, A; Reinisalo, M. 2019. Scientific reports. 9: 13761

Nucleic acid delivery to differentiated retinal pigment epithelial cells using cell-penetrating peptide as a carrier

Subia, B; Reinisalo, M; Dey, N; Tavakoli, S; Subrizi, A; Ganguli, M; Ruponen, M. 2019. European journal of pharmaceutics and biopharmaceutics. 140: 91-99

Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits

Fayyaz, A; Ranta, VP; Toropainen, E; Vellonen, KS; Ricci, GD; Reinisalo, M; Heikkinen, EM; Gardner, I; Urtti, A; Jamei, M; del Amo, EM. 2019. Molecular pharmaceutics. 12: e007045

Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters

Hellinen, Laura; Sato, Kazuki; Reinisalo, Mika; Kidron, Heidi; Rilla, Kirsi; Tachikawa, Masanori; Uchida, Yasuo; Terasaki, Tetsuya; Urtti, Arto. 2019. Investigative ophthalmology and visual science. 60: 5022-5034

Retinal Pigment Epithelial Cell Line with Fast Differentiation and Improved Barrier Properties

Hellinen, L; Pirskanen, L; Tengvall-Unadike, U; Urtti, A; Reinisalo, M. 2019. Pharmaceutics. 11: 412

The basis for strain-dependent rat aldehyde dehydrogenase 1A7 (ALDH1A7) gene expression

Touloupi, K; Kublbeck, J; Magklara, A; Molnar, F; Reinisalo, M; Konstandi, M; Honkakoski, P; Pappas, P. 2019. Molecular pharmacology. 96: 655-663

Implications of melanin binding in ocular drug delivery

Rimpelä, Anna-Kaisa; Reinisalo, Mika; Hellinen, Laura; Grazhdankin, Evgeni; Kidron, Heidi; Urtti Arto; del Amo, Eva M. 2018. Advanced drug delivery reviews. 126: 23-43

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. 2018. Redox biology. 2019; 20: 1-12

Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells

Juuti-Uusitalo K, Koskela A, Kivinen N, Viiri J, Hyttinen JMT, Reinisalo M, Koistinen A, Uusitalo H, Sinha D, Skottman H, Kaarniranta K. 2017. International journal of molecular sciences. 18: 1089

LC-MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line

Pelkonen L, Sato K, Reinisalo M, Kidron H, Tachikawa M, Watanabe M, Uchida Y, Urtti A, Terasaki T. 2017. Molecular pharmaceutics. 14: 605-613

Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts

Pelkonen L, Tengvall-Unadike U, Ruponen M, Kidron H, del Amo EM, Reinisalo M, Urtti A. 2017. European journal of pharmaceutical sciences. 109: 162-168

Pharmacokinetic aspects of retinal drug delivery

del Amo Eva M, Rimpelä Anna-Kaisa, Heikkinen Emma, Kari Otto K, Ramsay Eva, Lajunen Tatu, Schmitt Mechthild, Pelkonen Laura, Bhattacharya Madhushree, Richardson Dominique, Subrizi Astrid, Turunen Tiina, Reinisalo Mika, Itkonen Jaakko, Toropainen Elisa, Casteleijn Marco, Kidron Heidi, Antopolsky Maxim, Vellonen Kati-Sisko, Ruponen Marika, et al.. 2017. Progress in retinal and eye research. 57: 134-185

Acute cytotoxic effects of marketed ophthalmic formulations on human corneal epithelial cells

Hakkarainen Jenni J, Reinisalo Mika, Ragauskas Symantas, Seppänen Aila, Kaja Simon, Kalesnykas Giedrius. 2016. International journal of pharmaceutics. 511: 73-78

Isolation of Intact and Functional Melanosomes from the Retinal Pigment Epithelium

Pelkonen Laura, Reinisalo Mika, Morin-Picardat Emmanuelle, Kidron Heidi, Urtti Arto. 2016. PLoS ONE. 11: e0160352

Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells

Koskela Ali, Reinisalo Mika, Petrovski Goran, Sinha Debasish, Olmiere Céline, Karjalainen Reijo, Kaarniranta Kai. 2016. Nutrients. 8: 284

Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases

Reinisalo Mika, Kårlund Anna, Koskela Ali, Kaaniranta Kai, Karjalainen Reijo O.. 2015. Oxidative medicine and cellular longevity. 2015, Article ID 340520: 24 p.

Pinosylvin-mediated protection against oxidative stress in human retinal pigment epithelial cells

Koskela Ali, Reinisalo Mika, Hyttinen Juha MT, Kaarniranta Kai, Karjalainen Reijo O. 2014. Molecular vision. 20: 760-769

Regulation of the human tyrosinase gene in retinal pigment epithelium cells: the significance of transcription factor orthodenticle homeobox 2 and its polymorphic binding site

Reinisalo Mika, Putula Jaana, Mannermaa Eliisa, Urtti Arto, Honkakoski Paavo. 2012. Molecular vision. 18: 38-54

Studies on Retina-specific Gene Expression

Reinisalo Mika. 2012. Publications of the University of Eastern Finland. Dissertations in Health Sciences

Effect of freeze-drying conditions on transfection efficiency of cationic polymer DNA complexes

Kauppinen Ari, Reinisalo Mika, Pellinen Riikka, Korhonen Ossi, Järvinen Kristiina, Ketolainen Jarkko. 2010. Polymorfi

Filter-cultured ARPE-19 cells as outer blood-retinal barrier model

Mannermaa E, Reinisalo M, Ranta V-P, Vellonen K-S, Kokki H, Saarikko A, Kaarniranta K & Urtti A. 2010. European journal of pharmaceutical sciences. 40: 289-296

Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors

Küblbeck J, Reinisalo M, Mustonen R & Honkakoski P. 2010. European journal of pharmaceutical sciences. 40: 263-272

Determining the critical properties of formulations for freeze drying by DSC and FDM

Kauppinen Ari, Reinisalo Mika, Pellinen Riikka, Gieseler Henning, Schneid Stefan, Rutzinger Susanne, Beirowski Jakob, Korhonen Ossi, Järvinen Kristiina, Ketolainen Jarkko. 2009.

Intracellular DNA release and elimination correlate poorly with transgene expression after non-viral transfection

Ruponen M, Arkko S, Urtti A, Reinisalo M, Ranta V-P. 2009. Journal of controlled release. 136: 226-231

Microarray analysis of the global alterations in the gene expression in the placentas from cigarette-smoking mothers

Huuskonen P, Storvik M, Reinisalo M, Honkakoski P, Rysä J, Hakkola J, Pasanen M. 2008. Clinical pharmacology and therapeutics. 83: 542-550

Polyplex-mediated gene transfer and cell cycle: effect of carrier on cellular uptake and intracellular kinetics, and significance of glycosaminoglycans

Männistö M, Reinisalo M, Ruponen M, Honkakoski P, Tammi M, Urtti A. 2007. Journal of gene medicine. 9: 479-487

Freeze-drying of cationic polymer DNA complexes enables their long-term storage and reverse transfection of post-mitotic cells

Reinisalo M, Urtti A, Honkakoski P. 2006. Journal of controlled release. 110: 437-443

Absorption properties and P-glycoprotein activity of modified Caco-2 cell lines

Korjamo T, Honkakoski P, Toppinen M-R, Niva S, Reinisalo M, Palmgrén JJ, Mönkkönen J. 2005. European journal of pharmaceutical sciences. 26: 266-279

Long-lasting secretion of transgene product from differentiated and filter-grown retinal pigment epithelial cells after nonviral gene transfer

Mannermaa E, Rönkkö S, Ruponen M, Reinisalo M, Urtti A. 2005. Current eye research. 30: 345-353

Dual action of oestrogens on the mouse constitutive androstane receptor

Mäkinen J, Reinisalo M, Niemi K, Viitala P, Jyrkkärinne J, Chung H, Pelkonen O, Honkakoski P. 2003. Biochemical journal. 376: 465-472

Retina-specific gene expression and improved DNA transfection in WERI-Rb1 retinoblastoma cells

Reinisalo M, Urtti A, Honkakoski P. 2003. BIOCHIMICA ET BIOPHYSICA ACTA - GENE STRUCTURE AND EXPRESSION. 1628: 169-176

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Keywords

Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues

Intravitreal CendR peptides target laser-induced choroidal neovascularization sites in mice

Selective drug delivery to the retinal cells: Biological barriers and avenues

Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions

Mechanisms of cellular retention of melanin bound drugs: Experiments and computational modeling

Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations

Structural Features Affecting the Interactions and Transportability of LAT1-Targeted Phenylalanine Drug Conjugates

Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: tissue exposures in the rabbit eye

Microscale Thermophoresis as a Screening Tool to Predict Melanin Binding of Drugs

Characterization of artificially re-pigmented ARPE-19 retinal pigment epithelial cell model

Nucleic acid delivery to differentiated retinal pigment epithelial cells using cell-penetrating peptide as a carrier

Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits

Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters

Retinal Pigment Epithelial Cell Line with Fast Differentiation and Improved Barrier Properties

The basis for strain-dependent rat aldehyde dehydrogenase 1A7 (ALDH1A7) gene expression

Implications of melanin binding in ocular drug delivery

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells

LC-MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line

Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts

Pharmacokinetic aspects of retinal drug delivery

Acute cytotoxic effects of marketed ophthalmic formulations on human corneal epithelial cells

Isolation of Intact and Functional Melanosomes from the Retinal Pigment Epithelium

Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells

Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases

Pinosylvin-mediated protection against oxidative stress in human retinal pigment epithelial cells

Regulation of the human tyrosinase gene in retinal pigment epithelium cells: the significance of transcription factor orthodenticle homeobox 2 and its polymorphic binding site

Studies on Retina-specific Gene Expression

Effect of freeze-drying conditions on transfection efficiency of cationic polymer DNA complexes

Filter-cultured ARPE-19 cells as outer blood-retinal barrier model

Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors

Determining the critical properties of formulations for freeze drying by DSC and FDM

Intracellular DNA release and elimination correlate poorly with transgene expression after non-viral transfection

Microarray analysis of the global alterations in the gene expression in the placentas from cigarette-smoking mothers

Polyplex-mediated gene transfer and cell cycle: effect of carrier on cellular uptake and intracellular kinetics, and significance of glycosaminoglycans

Freeze-drying of cationic polymer DNA complexes enables their long-term storage and reverse transfection of post-mitotic cells

Absorption properties and P-glycoprotein activity of modified Caco-2 cell lines

Long-lasting secretion of transgene product from differentiated and filter-grown retinal pigment epithelial cells after nonviral gene transfer

Dual action of oestrogens on the mouse constitutive androstane receptor

Retina-specific gene expression and improved DNA transfection in WERI-Rb1 retinoblastoma cells