Mikko Gynther
Senior Researcher
School of Pharmacy, Faculty of Health Sciences
mikko.gynther@uef.fi | +358 50 917 7978
Research groups
Publications
49/49 items-
Sex-specific changes in protein expression of membrane transporters in the brain cortex of 5xFAD mouse model of Alzheimer’s disease
Puris, Elena; Saveleva, Liudmila; Auriola, Seppo; Gynther, Mikko; Kanninen, Katja M; Fricker, Gert. 2024. Frontiers in pharmacology. 15: . 1365051 -
In vitro identification of decreased function phenotype ABCG2 variants
Suominen, Laura; Sjöstedt, Noora; Vellonen, Kati-Sisko; Gynther, Mikko; Auriola, Seppo; Kidron, Heidi. 2023. European journal of pharmaceutical sciences. 188: -
Metabolomic, Lipidomic and Proteomic Characterisation of Lipopolysaccharide-induced Inflammation Mouse Model
Puris, Elena; Kouřil, Štěpán; Najdekr, Lukáš; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Gómez-Budia, Mireia; Fricker, Gert; Kanninen, Katja M; Malm, Tarja; Friedecký, David; Gynther, Mikko. 2022. Neuroscience. 496: 165-178 -
Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice
Puris, Elena; Jalkanen, Aaro; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2022. Brain disorders. 6: -
L-Type Amino Acid Transporter 1-Utilizing Prodrugs of Ketoprofen Can Efficiently Reduce Brain Prostaglandin Levels
Montaser, Ahmed; Lehtonen, Marko; Gynther, Mikko; Huttunen, Kristiina. 2020. Pharmaceutics. 12: 344 -
L-Type amino acid transporter 1 as a target for drug delivery
Puris, Elena; Gynther, Mikko; Auriola, Seppo; Huttunen, Kristiina. 2020. Pharmaceutical research. 37: 88 -
L-Type Amino Acid Transporter 1 (LAT1)-Utilizing Prodrugs Are Carrier-Selective Despite Having Low Affinity for Organic Anion Transporting Polypeptides (OATPs)
Huttunen, Johanna; Gynther, Mikko; Vellonen, KatiSisko; Huttunen, Kristiina M. 2019. International journal of pharmaceutics. 571: 118714 -
L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia
Huttunen J, Peltokangas S, Gynther M, Natunen T, Hiltunen M, Auriola S, Ruponen M, Vellonen KS, Huttunen KM. 2019. Scientific reports. 9: 12860 -
L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery
Puris, E; Gynther, M; Huttunen, J; Auriola, S; Huttunen, KM. 2019. European journal of pharmaceutical sciences. 129: 99-109 -
Laparoscopic Roux-en-Y gastric bypass surgery influenced pharmacokinetics of several drugs given as a cocktail with the highest impact observed for CYP1A2, CYP2C8 and CYP2E1 substrates
Puris, E; Pasanen, M; Ranta, VP; Gynther, M; Petsalo, A; Käkelä, P; Männistö, V; Pihlajamäki, J. 2019. Basic and clinical pharmacology and toxicology. 125: 123-132