Dr. Nissi is an Associate Professor at the Department of Applied Physics at the University of Eastern Finland, Kuopio, Finland. From the beginning of 2021, Dr. Nissi has also served as a deputy head of the department. Dr. Nissi leads a research group focusing on pre-clinical quantitative magnetic resonance imaging (qMRI). The research topics in the group include relaxometry methods, such as various rotating and laboratory frame relaxation methods and imaging strategies, as well as quantitative susceptibility mapping. While the primary field of target applications for qMRI in Dr. Nissi’s group has been musculoskeletal diseases and their diagnostics, the research interests of his group concern especially methodological development of ultra-short echo time / SWIFT imaging sequences as well as image acquisition and reconstruction strategies for various target applications.
The most recent project fundings granted to Dr. Nissi concern development of rapid quantitative ultra-short echo time MRI methods using primarily the SWIFT sequence and its variants and iterative compressed sensing reconstruction methods (Academy of Finland, grant #325146) and developing an innovation and development environment for industrial applications of material research using microMRI, consisting of investment of an 11.74 T microMRI device and of various pilot projects on microMRI of agricultural and industrial products (European Regional Development Fund, grants #A73998 and #A74016).
Faculty of Science and Forestry, Department of Applied Physics
+358 50 595 5517
Research groups and research projects
RESEARCH GROUPS - UEF
Jiang, Zhirui; Johnson, Casey P; Nykänen, Olli; Nissi, Mikko; Lau, Yian Khai; Wu, Meilun; Casal, Margret L; Smith, Lachlan J. 2021. Epiphyseal Cartilage Canal Architecture and Extracellular Matrix Remodeling in Mucopolysaccharidosis VII Dogs at the Onset of Postnatal Growth Connective tissue research [Epub ahead of print 11 Jan 2021]: 1-11. 2021
Saukko, AEA; Sarin, JK; Nykänen, O; Nissi, MJ; Te Moller, NCR; Weinans, H; Mancini, IAD; Visser, J; Brommer, H; van Weeren, PR; Malda, J; Grinstaff, MW; Töyräs, J. 2021. Dual-contrast computed tomography enables detection of equine posttraumatic osteoarthritis in vitro Journal of orthopaedic research [First published: 12 May 2021]: 1-9. 2021
Bolcos, PO; Mononen, ME; Tanaka, MS; Yang, M; Suomalainen, JS; Nissi, MJ; Töyräs, J; Ma, B; Li, X; Korhonen, RK. 2020. Identification of locations susceptible to osteoarthritis in patients with anterior cruciate ligament reconstruction: Combining knee joint computational modelling with follow-up T1p and T2 imaging Clinical biomechanics 79: 104844. 2020
Chary, Karthik; Nissi, Mikko J; Nykänen, Olli; Manninen, Eppu; Rey, Ramón I; Shmueli, Karin; Sierra, Alejandra; Gröhn, Olli. 2020. Quantitative susceptibility mapping of the rat brain after traumatic brain injury Nmr in biomedicine 2021; 34 2: e4438. 2020
Filip, Pavel; Svatkova, Alena; Carpenter, Adam F; Eberly, Lynn E; Nestrasil, Igor; Nissi, Mikko J; Michaeli, Shalom; Mangia, Silvia. 2020. Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis Neuroimage. clinical 26: 102234. 2020
Husso, Minna; Afara, Isaac O; Nissi, Mikko J; Kuivanen, Antti; Halonen, Paavo; Tarkia, Miikka; Teuho, Jarmo; Saunavaara, Virva; Vainio, Pauli; Sipola, Petri; Manninen, Hannu; Ylä-Herttuala, Seppo; Knuuti, Juhani; Töyräs, Juha. 2020. Quantification of Myocardial Blood Flow by Machine Learning Analysis of Modified Dual Bolus MRI Examination Annals of biomedical engineering 2021; 49: 653-662. 2020
Hänninen, Nina Elina; Nykänen, Olli; Prakash, Mithilesh; Hanni, Matti; Nieminen, Miika Tapio; Nissi, Mikko Johannes. 2020. Orientation anisotropy of quantitative MRI parameters in degenerated human articular cartilage Journal of orthopaedic research [Published online 29 June 2020]: 1-10. 2020
Kajabi, Abdul Wahed; Casula, Victor; Ojanen, Simo; Finnilä, Mikko A; Herzog, Walter; Saarakkala, Simo; Korhonen, Rami K; Nissi, Mikko J; Nieminen, Miika T. 2020. Multiparametric MR Imaging Reveals Early Cartilage Degeneration at 2 and 8 Weeks After ACL Transection in a Rabbit Model Journal of orthopaedic research 38 9: 1974-1986. 2020
Kajabi, Abdul Wahed; Casula, Victor; Sarin, Jaakko K; Ketola, Juuso H; Nykänen, Olli; Te Moller, Nikae C R; Mancini, Irina A D; Visser, Jetze; Brommer, Harold; René van Weeren, P; Malda, Jos; Töyräs, Juha; Nieminen, Miika T; Nissi, Mikko J. 2020. Evaluation of articular cartilage with quantitative MRI in an equine model of post-traumatic osteoarthritis Journal of orthopaedic research 2021; 39 1: 63-73. 2020
Nykänen, Olli; Leskinen, Henri P P; Finnilä, Mikko; Karhula, Sakari S; Turunen, Mikael J; Töyräs, Juha; Saarakkala, Simo; Nissi, Mikko J. 2020. Bright ultra-short echo time SWIFT MRI signal at the osteochondral junction is not located in the calcified cartilage Journal of orthopaedic research 38 12: 2649-2656. 2020